MCID: CNG034
MIFTS: 69

Congestive Heart Failure malady

Cardiovascular diseases category

Aliases & Classifications for Congestive Heart Failure

About this section

Congestive Heart Failure, Aliases & Descriptions:

Name: Congestive Heart Failure 30 9 11 60
Cardiac Failure Congestive 9
Congestive Heart Disease 9
Heart Failure Congestive 43
 
Heart Failure 60
Weak Heart 9
Chf 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Summaries for Congestive Heart Failure

About this section


Disease Ontology:9 A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.

MalaCards based summary: Congestive Heart Failure, also known as cardiac failure congestive, is related to central sleep apnea and mitral valve disease. An important gene associated with Congestive Heart Failure is PLN (phospholamban), and among its related pathways are Monoamine GPCRs and Cardiomyocyte Differentiation through BMP Receptors. The drugs captopril and enalapril and the compounds candoxatril and imidapril have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain, and related mouse phenotypes are renal/urinary system and muscle.

Related Diseases for Congestive Heart Failure

About this section

Diseases related to Congestive Heart Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1central sleep apnea31.9NPPB
2mitral valve disease31.7NPPA
3atrial fibrillation31.3ADRB1, ACE, NPPA, NPPB
4cor pulmonale31.1NPPA, NPPB
5pulmonary hypertension30.9ADM, NPPB, NPPA
6myocarditis30.8NPPB, ADRB1
7coronary artery disease30.8NPPB, ADRB1, FABP3, ACE
8syndrome of inappropriate antidiuretic hormone30.7NPPA, NPPB
9hypertensive heart disease30.7NPPB, NPPA, ACE
10mitral valve insufficiency30.7NPPB, NPPA
11dilated cardiomyopathy30.6VCL, ADRB1, FABP3, ACE, PLN, NPPA
12chagas disease30.6NPPB, ADRB1
13kawasaki disease30.6NPPB, ADM
14hypokalemia30.5ACE, REN
15congenital heart disease30.4UTS2, NPPB, NPPA, ADM
16hyperaldosteronism30.4NPPA, ACE, REN
17cerebrovascular disease30.1ADM, ACE
18liver cirrhosis30.1REN, NPPA, UTS2, ADM
19pheochromocytoma30.0ADM, UTS2, NPPA
20renovascular hypertension29.9ADM, REN, ACE, NPPA
21acute myocardial infarction29.8ACE, NPPA, UTS2, NPPB, ADM, ADRB1
22proteinuria29.8ADM, REN, ACE, UTS2
23ischemia29.8FABP3, ADM, VCL, NPPB, AMPD1
24myocardial infarction29.7REN, ADRB1, ADM, NPPB, NPPA, UTS2
25sleep apnea10.8
26endotheliitis10.8
27peritonitis10.7
28blindness10.6
29artery disease10.6
30endocarditis10.6
31kidney disease10.6
32pneumonia10.5
33hypoaldosteronism10.5REN
34oligohydramnios10.5ACE
35fibromuscular dysplasia10.4REN
36ischemic heart disease10.4
37subacute bacterial endocarditis10.4
38arteriovenous malformation10.4
39right bundle branch block10.4
40aneurysm10.4
41sick sinus syndrome10.4NPPA
42asthma10.4
43obesity10.4
44hepatitis10.4
45acromegaly10.4
46endocardial fibroelastosis10.4
47hypertrophic cardiomyopathy10.4
48diastolic heart failure10.4
49pulmonary edema10.4
50patent ductus arteriosus10.4

Graphical network of the top 20 diseases related to Congestive Heart Failure:



Diseases related to congestive heart failure

Symptoms for Congestive Heart Failure

About this section

Drugs & Therapeutics for Congestive Heart Failure

About this section

Drug clinical trials:

Search ClinicalTrials for Congestive Heart Failure

Search NIH Clinical Center for Congestive Heart Failure

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Congestive Heart Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Congestive Heart Failure:
Adipose-derived stem cells for treatment of congestive heart failure
BMAC
Bone marrow-derived adult mononuclear cells for heart diseases
Cardiac progenitor cells for single-ventricle anomalies
Cardiosphere-derived autologous stem cells for reverse ventricular dysfunction
C-Cure
CD133+ bone marrow-derived stem cells in conjuction with coronary artery bypass grafting
CD34+ stem cells for treatment of congestive heart failure
Enriched bone marrow-derived progenitor cells for heart diseases
ERCs, endometrial regenerative cells for congestive heart failure
Human cardiac-derived stem cell for the treatment of congestive heart failure
Mesenchymal precursor cells for cardiovascular diseases
MyoCell
Peripheral or bone marrow-derived stem cells for chronic heart failure
Embryonic/Adult Cultured Cells Related to Congestive Heart Failure:
Adipose-derived mesenchymal stem cells (family)
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC), PMIDs: 15995108, 19896796, 18351022
Bone marrow-derived mononuclear cells, PMIDs: 22137069, 19699857, 20445812, 20524773
Cardiac progenitor cells, PMIDs: 18754813, 17502484, 14530411
Cardiac stem cells, PMIDs: 18754813, 17502484, 14530411
Cardiosphere-derived cells, PMID: 22336189
Cardiomyocyte-like cells, PMIDs: 23583247, 18835562
Bone marrow-derived CD133+ cells, PMID: 17320570
Bone marrow-derived hematopoietic stem cells (family), PMID: 22163120
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Endometrial regenerative cells , PMIDs: 18005405, 23510656, 20398245, 19232091
Human cardiac stem cells, PMIDs: 17502484, 19038683, 17150190
Mesenchymal Precursor Cells (STRO-3 selected), PMIDs: 20850099, 21155976
Skeletal myoblasts (MyoCell, PMIDs: 19051139, 15615560, 16446778
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565

Genetic Tests for Congestive Heart Failure

About this section

Anatomical Context for Congestive Heart Failure

About this section

MalaCards organs/tissues related to Congestive Heart Failure:

31
Heart, Bone, Brain, Endothelial, Kidney, Lung, Testes, Bone marrow, Liver, Skeletal muscle, Thyroid, Breast, Monocytes, Colon, Skin, Prostate, Myeloid, T cells, Cardiac myocytes, Pituitary, Neutrophil

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Congestive Heart Failure:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 Lateral Plate MesodermSplanchnic MesodermPericytes Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Congestive Heart Failure or affiliated genes

About this section

MGI Mouse Phenotypes related to Congestive Heart Failure:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3NPPA, PDCD1, ACE, REN, ADM
2MP:00053697.0NPPB, ADRB1, ADM, FABP3, REN, VCL
3MP:00107686.9ADM, ADRA2C, VCL, PDCD1, FABP3, REN
4MP:00053766.9NPPA, PLN, ADRB1, ACE, REN, FABP3
5MP:00053856.4NPPA, NPPB, PLN, ACE, REN, FABP3

Publications for Congestive Heart Failure

About this section

Articles related to Congestive Heart Failure:

(show top 50)    (show all 1255)
idTitleAuthorsYear
1
Effective treatment of congestive heart failure using adaptive servo-ventilation in an end-stage renal disease patient on hemodialysis. (25224193)
2014
2
Congestive heart failure: an unusual presentation of pseudohypoparathyroidism. (23823262)
2013
3
Left Atrial Remodeling and Recurrence of Congestive Heart Failure in Patients Initially Diagnosed with Heart Failure. (24372958)
2013
4
Dynamic cardiac output regulation at rest, during exercise, and muscle metaboreflex activation: impact of congestive heart failure. (22855278)
2012
5
A case of unilateral pleural effusion secondary to congestive heart failure successfully treated with traditional Chinese herbal formulas. (22537563)
2012
6
Extracorporeal ultrafiltration for congestive heart failure patients. (21625112)
2011
7
Hospital discharge plan for patients with congestive heart failure. (22249681)
2011
8
A remote patient monitoring system for congestive heart failure. (21611788)
2011
9
Vitamin D deficiency in patients with congestive heart failure: mechanisms, manifestations, and management. (21606710)
2011
10
Cardiac status assessment with a multi-signal device for improved home-based congestive heart failure management. (22254450)
2011
11
N-terminal pro-b-type natriuretic peptide and left atrial function in patients with congestive heart failure and severely reduced ejection fraction. (21685193)
2011
12
Nurse-led self-management group programme for patients with congestive heart failure: randomized controlled trial. (20492026)
2010
13
Disease management 360 degrees: a scorecard approach to evaluating TRICARE's programs for asthma, congestive heart failure, and diabetes. (20613658)
2010
14
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
15
Discovery of new cardiovascular hormones for the treatment of congestive heart failure. (17346128)
2007
16
Significance of combined angiotensin II receptor blocker and carvedilol therapy in patients with congestive heart failure and arginine variant. (16475467)
2006
17
The significance of CA125 levels in patients with chronic congestive heart failure. Correlation with clinical and echocardiographic parameters. (15701467)
2005
18
Proinflammatory cytokines, soluble Fas receptor, nitric oxide and angiotensin converting enzyme in congestive heart failure. (16734138)
2005
19
Plasma B-type natriuretic peptide levels and risk factors for congestive heart failure in a Japanese general population. (16043942)
2005
20
Undertreatment of congestive heart failure in an Australian setting. (14748893)
2004
21
TNF and congestive heart failure: therapeutic possibilities. (15161427)
2004
22
Is hormonal activation during exercise useful for risk stratification in patients with moderate congestive heart failure? (15309008)
2004
23
Evidence for the survival benefit of neurohormonal antagonists in the management of geriatric congestive heart failure. (12688226)
2003
24
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
25
Patterns of pharmacologic treatment of congestive heart failure in elderly nursing home residents and related issues: a review of the literature. (12946542)
2003
26
Impact of pharmacotherapy on lymphocyte volumes and activity of the Na+/H+ exchanger in patients with congestive heart failure. (11771856)
2001
27
Endothelin A receptor antagonists in congestive heart failure: blocking the beast while leaving the beauty untouched? (11447305)
2001
28
Comparison of the first dose response of fosinopril and captopril in congestive heart failure: a randomized, double-blind, placebo controlled study. (11384079)
2001
29
Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure. (11181472)
2001
30
Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II). (11157688)
2001
31
Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. (11300427)
2001
32
Relationship between endothelin-1 extraction in the peripheral circulation and systemic vascular resistance in patients with severe congestive heart failure. (9973035)
1999
33
Improving outcomes in congestive heart failure: Val-HeFT. Valsartan in Heart Failure Trial. (10449891)
1999
34
Levels of adrenomedullin in plasma of patients with chronic congestive heart failure]. (9686497)
1998
35
Hemodynamic and neurohumoral effects of long-term prostaglandin E1 infusions in outpatients with severe congestive heart failure. (9171275)
1997
36
Pharmacology of carvedilol: rationale for use in hypertension, coronary artery disease, and congestive heart failure. (9211017)
1997
37
Effect of prolonged catecholamine infusion on immunoregulatory function: implications in congestive heart failure. (7797738)
1995
38
ACE inhibitors and calcium antagonists in the treatment of congestive heart failure. (8562467)
1995
39
Prognostic value of plasma catecholamines, plasma renin activity, and plasma atrial natriuretic peptide at rest and during exercise in congestive heart failure: comparison with clinical evaluation, ejection fraction, and exercise capacity. (9420653)
1995
40
Atrial natriuretic peptide in congestive heart failure after acute myocardial infarction. (8519004)
1993
41
Optimising ACE inhibitor therapy of congestive heart failure. Insights from pharmacodynamic studies. (8448973)
1993
42
Renal and electrolyte complications of congestive heart failure and effects of therapy with angiotensin-converting enzyme inhibitors. (1558426)
1992
43
Hormonal changes in patients with severe chronic congestive heart failure treated by ultrafiltration. (1317520)
1992
44
Beneficial effects of trandolapril on experimentally induced congestive heart failure in rats. (1414925)
1992
45
Cardiovascular and hormonal effects of calcitonin gene-related peptide in congestive heart failure. (1987228)
1991
46
Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure. (1720384)
1991
47
Role of atrial natriuretic peptide in congestive heart failure due to chronic diabetes. (1832580)
1991
48
Gamma 2-MSH in congestive heart failure: relation to atrial natriuretic peptide, arginine vasopressin and catecholamines. (2138208)
1990
49
Contracted form of primary endocardial fibroelastosis in a young adult without congestive heart failure. (3398240)
1988
50
On congestive heart failure after clinically healed subacute bacterial endocarditis. (18864134)
1948

Variations for Congestive Heart Failure

About this section

Expression for genes affiliated with Congestive Heart Failure

About this section
Search GEO for disease gene expression data for Congestive Heart Failure.

Pathways for genes affiliated with Congestive Heart Failure

About this section

Pathways related to Congestive Heart Failure according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9ADRA2C, ADRB1
29.8NPPB, NPPA
3
Show member pathways
9.7REN, ACE
4
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.5ADRB1, ACE, PLN
5
Show member pathways
9.2ADRA2C, ADRB1, UTS2, PLN
6
Show member pathways
Calcium Regulation in the Cardiac Cell36
9.1ADM, ADRB1, PLN
79.1ADRB1, ADRA2C, ADM
8
Show member pathways
8.6UTS2, ADRA2C, ADRB1, ADM

Compounds for genes affiliated with Congestive Heart Failure

About this section

Compounds related to Congestive Heart Failure according to GeneCards Suite gene sharing:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1candoxatril43 1210.8ACE, NPPA, NPPB
2imidapril43 4910.7NPPB, NPPA, ACE
3ibopamine439.7ACE, REN, NPPA
4urodilatin439.7REN, NPPB, NPPA
5fenoldopam43 1210.7NPPA, REN, ADRA2C
6dobutamine43 28 49 1212.6NPPB, NPPA, ADRB1
7hanp439.6NPPA, NPPB, REN
8bucindolol43 4910.5ACE, REN, ADRA2C, ADRB1
9cilazapril43 1210.5NPPA, ACE, REN
10alacepril439.5NPPB, ACE, NPPA, REN
11trandolapril43 1210.5REN, NPPB, NPPA, ACE
12atenolol43 49 28 24 1213.5ADRB1, REN, NPPB, ACE
13fosinopril43 1210.4NPPA, NPPB, REN, ACE
14moxonidine439.4NPPA, NPPB, ACE, REN
15enalaprilat439.4NPPA, REN, ACE, NPPB
16lisinopril43 49 24 1212.4REN, ACE, NPPA, NPPB
17ramipril43 1210.4ACE, NPPA, NPPB, REN
18benazepril43 49 1211.4REN, NPPA, ACE
19perindopril43 49 1211.4NPPA, ACE, REN, NPPB
20amlodipine43 49 24 1212.4REN, ACE, NPPA, NPPB
21enalapril43 49 1211.4NPPB, REN, ACE, NPPA
22spironolactone43 59 28 49 1213.4REN, ACE, NPPA, NPPB
23digoxin43 59 49 24 1213.3REN, ACE, NPPA, NPPB
24furosemide43 59 28 49 24 1214.3NPPB, ACE, REN, NPPA
25quinapril43 49 1211.2NPPA, ACE, REN
26bisoprolol43 49 1211.2ADRB1, REN, NPPA, NPPB, ACE
27metoprolol43 49 28 24 1213.2NPPB, REN, ADRB1, ACE, NPPA
28omapatrilat439.0NPPA, ADM, REN, ACE
29phosphoramidon43 129.9NPPB, ADM, NPPA, ACE
30mibg438.9NPPA, ADM, NPPB, FABP3
31phenylephrine43 28 24 1211.7NPPA, NPPB, ADRB1, UTS2, ADM
32nitroglycerin43 129.6ACE, REN, NPPB, ADM, NPPA
33ang ii438.6ACE, REN, ADM, NPPB, NPPA
34captopril43 59 49 28 1212.6NPPB, ACE, REN, ADM, NPPA
35isoproterenol43 129.6ADRB1, ADM, REN, NPPA, NPPB
36losartan43 49 28 1211.6ACE, NPPA, NPPB, ADM, REN
37propranolol43 28 49 24 1212.5ADRB1, AMPD1, ADM, REN, NPPA
38catecholamine438.5ADRA2C, NPPB, NPPA, REN, ADRB1, ADM
39prostacyclin438.4ADM, REN, ACE, NPPA, NPPB
40carvedilol43 49 28 1211.4ADRB1, REN, ADM, NPPB, ACE, NPPA
41epinephrine43 24 1210.3ADRB1, REN, NPPA, ADM, NPPB
42forskolin43 49 1210.3ADRA2C, ADM, NPPA, NPPB, ADRB1, REN
43acetylcholine43 49 28 24 1212.2ACE, UTS2, VCL, ADM, NPPB
44sodium43 248.8ACE, REN, UTS2, ADRB1, ADM, NPPB
45creatinine437.6REN, FABP3, UTS2, NPPB, NPPA, ADM
46nitric oxide43 24 129.6ADRB1, NPPB, VCL, ACE, UTS2, ADM
47lipid437.4UTS2, ADM, NPPB, ADRB1, PLN, VCL
48norepinephrine43 24 129.1REN, ACE, NPPA, NPPB, FABP3, UTS2
49tyrosine436.9PDCD1, FABP3, UTS2, NPPB, ADRB1, ADM
50glucose436.9NPPB, AMPD1, VCL, ADRB1, ADM, UTS2

GO Terms for genes affiliated with Congestive Heart Failure

About this section

Cellular components related to Congestive Heart Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.5VCL, ADM, UTS2, REN, ACE, NPPA
2extracellular spaceGO:00056156.8ADM, UTS2, CBR3, REN, ACE, NPPA

Biological processes related to Congestive Heart Failure according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle cell contractionGO:008600410.2ADRB1, PLN
2cGMP biosynthetic processGO:000618210.1NPPB, NPPA
3negative regulation of heart rateGO:001045910.1PLN, UTS2
4receptor guanylyl cyclase signaling pathwayGO:000716810.1NPPB, NPPA
5regulation of calcium ion transportGO:005192410.1ADRB1, PLN
6negative regulation of urine volumeGO:003581110.1UTS2, ADRB1
7regulation of vasodilationGO:004231210.0ACE, NPPB
8regulation of blood vessel sizeGO:005088010.0NPPB, NPPA
9angiotensin maturationGO:00020039.9REN, ACE
10response to testosteroneGO:00335749.8UTS2, PLN
11regulation of the force of heart contractionGO:00020269.6ADM, PLN
12positive regulation of heart rateGO:00104609.4ADM, UTS2
13blood circulationGO:00080159.4PLN, ADM
14female pregnancyGO:00075659.3ADRA2C, ADM, NPPA
15response to coldGO:00094099.3ADRB1, ADM
16positive regulation of vasodilationGO:00459099.2UTS2, ADM
17response to insulinGO:00328689.1ADM, FABP3, NPPA
18positive regulation of cAMP biosynthetic processGO:00308199.1ADM, ADRB1
19response to hypoxiaGO:00016669.0NPPA, UTS2, ADM
20regulation of blood pressureGO:00082178.9NPPB, NPPA, ACE, REN, UTS2

Molecular functions related to Congestive Heart Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:00513799.9ADRA2C, ADRB1
2alpha-2A adrenergic receptor bindingGO:00316949.6ADRA2C, ADRB1
3hormone activityGO:00051798.5NPPA, ADM, UTS2, NPPB
4receptor bindingGO:00051028.1NPPB, ADM, UTS2, REN, NPPA

Products for genes affiliated with Congestive Heart Failure

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Congestive Heart Failure

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet