CHF
MCID: CNG034
MIFTS: 78

Congestive Heart Failure (CHF) malady

Cardiovascular diseases category
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Summaries for Congestive Heart Failure

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Sources:
8Disease Ontology, 33MalaCards
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Fully expand this MalaCard
Disease Ontology:8 A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.

MalaCards: Congestive Heart Failure, also known as cardiac failure congestive, is related to central sleep apnea and mitral valve disease. An important gene associated with Congestive Heart Failure is PLN (phospholamban), and among its related pathways are Monoamine GPCRs and Cardiomyocyte Differentiation through BMP Receptors. The drugs inamrinone and atenolol and the compounds candoxatril and imidapril have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Congestive Heart Failure

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

congestive heart failure 8 10 31 62
cardiac failure congestive 8
congestive heart disease 8
heart failure congestive 45
heart failure 62
weak heart 8
chf 8


Related Diseases for Congestive Heart Failure

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Congestive Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1central sleep apnea31.3NPPB
2mitral valve disease31.1NPPA
3hypertension31.1REN, UTS2, NPPA, NPPB, ACE, ADM
4dilated cardiomyopathy31.0VCL, ADRB1, FABP3, ACE, PLN, NPPA
5coronary artery disease30.9NPPB, ADRB1, FABP3, ACE
6myocardial infarction30.8REN, ADRB1, ADM, NPPB, NPPA, UTS2
7diabetes mellitus30.7REN, ACE, NPPA, NPPB, UTS2
8cor pulmonale30.7NPPA, NPPB
9acute myocardial infarction30.6ACE, NPPA, UTS2, NPPB, ADM, ADRB1
10myocarditis30.5NPPB, ADRB1
11hypertensive heart disease30.5NPPB, NPPA, ACE
12congenital heart disease30.5UTS2, NPPB, NPPA, ADM
13liver cirrhosis30.4REN, NPPA, UTS2, ADM
14type 2 diabetes mellitus30.4ACE, ADM, UTS2
15syndrome of inappropriate antidiuretic hormone30.3NPPA, NPPB
16mitral valve insufficiency30.3NPPB, NPPA
17aortic valve stenosis30.3NPPB, NPPA
18chagas disease30.3NPPB, ADRB1
19ischemia30.3FABP3, ADM, VCL, NPPB, AMPD1
20hypokalemia30.3ACE, REN
21hyperaldosteronism30.3NPPA, ACE, REN
22kawasaki disease30.2NPPB, ADM
23renovascular hypertension30.2ADM, REN, ACE, NPPA
24proteinuria30.1ADM, REN, ACE, UTS2
25essential hypertension30.0ADRB1, ADM, UTS2, REN, ACE, NPPA
26sleep apnea10.8
27endotheliitis10.8
28peritonitis10.6
29blindness10.6
30artery disease10.6
31endocarditis10.6
32kidney disease10.5
33pneumonia10.5
34subacute bacterial endocarditis10.4
35arteriovenous malformation10.4
36right bundle branch block10.4
37aneurysm10.4
38acromegaly10.4
39hypertrophic cardiomyopathy10.4
40diastolic heart failure10.4
41pulmonary edema10.4
42asthma10.4
43hepatitis10.4
44obesity10.4
45thyroiditis10.4
46thyrotoxicosis10.4
47intracranial arteriovenous malformation10.4
48vein of galen aneurysm10.4
49wolff-parkinson-white syndrome10.3
50obstructive sleep apnea10.3

Graphical network of the top 20 diseases related to Congestive Heart Failure:



Diseases related to congestive heart failure

Symptoms for Congestive Heart Failure

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Drugs & Therapeutics for Congestive Heart Failure

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Congestive Heart Failure

Search NIH Clinical Center for Congestive Heart Failure

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Congestive Heart Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Congestive Heart Failure:
Adipose-derived stem cells for treatment of congestive heart failure
BMAC
Bone marrow-derived adult mononuclear cells for heart diseases
Cardiac progenitor cells for single-ventricle anomalies
Cardiosphere-derived autologous stem cells for reverse ventricular dysfunction
C-Cure
CD133+ bone marrow-derived stem cells in conjuction with coronary artery bypass grafting
CD34+ stem cells for treatment of congestive heart failure
Enriched bone marrow-derived progenitor cells for heart diseases
ERCs, endometrial regenerative cells for congestive heart failure
Human cardiac-derived stem cell for the treatment of congestive heart failure
Mesenchymal precursor cells for cardiovascular diseases
MyoCell
Peripheral or bone marrow-derived stem cells for chronic heart failure
Embryonic/Adult Cultured Cells Related to Congestive Heart Failure:
Adipose-derived mesenchymal stem cells (family)
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC), PMIDs: 15995108, 19896796, 18351022
Bone marrow-derived mononuclear cells, PMIDs: 22137069, 19699857, 20445812, 20524773
Cardiac progenitor cells, PMIDs: 18754813, 17502484, 14530411
Cardiac stem cells, PMIDs: 18754813, 17502484, 14530411
Cardiosphere-derived cells, PMID: 22336189
Cardiomyocyte-like cells, PMIDs: 23583247, 18835562
Bone marrow-derived CD133+ cells, PMID: 17320570
Bone marrow-derived hematopoietic stem cells (family), PMID: 22163120
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Endometrial regenerative cells , PMIDs: 18005405, 23510656, 20398245, 19232091
Human cardiac stem cells, PMIDs: 17502484, 19038683, 17150190
Mesenchymal Precursor Cells (STRO-3 selected), PMIDs: 20850099, 21155976
Skeletal myoblasts (MyoCell, PMIDs: 19051139, 15615560, 16446778
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565

Genetic Tests for Congestive Heart Failure

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Anatomical Context for Congestive Heart Failure

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Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Congestive Heart Failure:

33
Heart, Bone, Brain, Endothelial, Kidney, Testes, Lung, Liver, Bone marrow, Skeletal muscle, Thyroid, Monocytes, Breast, Prostate, Skin, Myeloid, T cells, Colon, Cardiac myocytes, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Congestive Heart Failure:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 Lateral Plate MesodermSplanchnic MesodermPericytes Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Congestive Heart Failure or affiliated genes

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Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Congestive Heart Failure:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3NPPA, PDCD1, ACE, REN, ADM
2MP:00053697.0VCL, ADRB1, ADM, FABP3, REN, PLN
3MP:00107686.9VCL, ADRB1, ADRA2C, ADM, FABP3, REN
4MP:00053766.9ADRB1, ADRA2C, ADM, FABP3, REN, ACE
5MP:00053856.4NPPB, VCL, ADRB1, ADRA2C, ADM, FABP3

Publications for Congestive Heart Failure

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Sources:
52PubMed
See all sources

Articles related to Congestive Heart Failure:

(show top 50)    (show all 1212)
idTitleAuthorsYear
1
Congestive heart failure: an unusual presentation of pseudohypoparathyroidism. (23823262)
2013
2
Left Atrial Remodeling and Recurrence of Congestive Heart Failure in Patients Initially Diagnosed with Heart Failure. (24372958)
2013
3
Dynamic cardiac output regulation at rest, during exercise, and muscle metaboreflex activation: impact of congestive heart failure. (22855278)
2012
4
A case of unilateral pleural effusion secondary to congestive heart failure successfully treated with traditional Chinese herbal formulas. (22537563)
2012
5
Extracorporeal ultrafiltration for congestive heart failure patients. (21625112)
2011
6
Hospital discharge plan for patients with congestive heart failure. (22249681)
2011
7
A remote patient monitoring system for congestive heart failure. (21611788)
2011
8
Vitamin D deficiency in patients with congestive heart failure: mechanisms, manifestations, and management. (21606710)
2011
9
Cardiac status assessment with a multi-signal device for improved home-based congestive heart failure management. (22254450)
2011
10
N-terminal pro-b-type natriuretic peptide and left atrial function in patients with congestive heart failure and severely reduced ejection fraction. (21685193)
2011
11
Nurse-led self-management group programme for patients with congestive heart failure: randomized controlled trial. (20492026)
2010
12
Disease management 360 degrees: a scorecard approach to evaluating TRICARE's programs for asthma, congestive heart failure, and diabetes. (20613658)
2010
13
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
14
Discovery of new cardiovascular hormones for the treatment of congestive heart failure. (17346128)
2007
15
Significance of combined angiotensin II receptor blocker and carvedilol therapy in patients with congestive heart failure and arginine variant. (16475467)
2006
16
Clinical and prognostic value of elevated CA125 levels in patients with congestive heart failure. (17134062)
2006
17
The significance of CA125 levels in patients with chronic congestive heart failure. Correlation with clinical and echocardiographic parameters. (15701467)
2005
18
Proinflammatory cytokines, soluble Fas receptor, nitric oxide and angiotensin converting enzyme in congestive heart failure. (16734138)
2005
19
Plasma B-type natriuretic peptide levels and risk factors for congestive heart failure in a Japanese general population. (16043942)
2005
20
Undertreatment of congestive heart failure in an Australian setting. (14748893)
2004
21
TNF and congestive heart failure: therapeutic possibilities. (15161427)
2004
22
Is hormonal activation during exercise useful for risk stratification in patients with moderate congestive heart failure? (15309008)
2004
23
Evidence for the survival benefit of neurohormonal antagonists in the management of geriatric congestive heart failure. (12688226)
2003
24
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
25
Patterns of pharmacologic treatment of congestive heart failure in elderly nursing home residents and related issues: a review of the literature. (12946542)
2003
26
Impact of pharmacotherapy on lymphocyte volumes and activity of the Na+/H+ exchanger in patients with congestive heart failure. (11771856)
2001
27
Endothelin A receptor antagonists in congestive heart failure: blocking the beast while leaving the beauty untouched? (11447305)
2001
28
Comparison of the first dose response of fosinopril and captopril in congestive heart failure: a randomized, double-blind, placebo controlled study. (11384079)
2001
29
Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure. (11181472)
2001
30
Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II). (11157688)
2001
31
Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. (11300427)
2001
32
Relationship between endothelin-1 extraction in the peripheral circulation and systemic vascular resistance in patients with severe congestive heart failure. (9973035)
1999
33
Improving outcomes in congestive heart failure: Val-HeFT. Valsartan in Heart Failure Trial. (10449891)
1999
34
Levels of adrenomedullin in plasma of patients with chronic congestive heart failure]. (9686497)
1998
35
Hemodynamic and neurohumoral effects of long-term prostaglandin E1 infusions in outpatients with severe congestive heart failure. (9171275)
1997
36
Pharmacology of carvedilol: rationale for use in hypertension, coronary artery disease, and congestive heart failure. (9211017)
1997
37
Effect of prolonged catecholamine infusion on immunoregulatory function: implications in congestive heart failure. (7797738)
1995
38
ACE inhibitors and calcium antagonists in the treatment of congestive heart failure. (8562467)
1995
39
Prognostic value of plasma catecholamines, plasma renin activity, and plasma atrial natriuretic peptide at rest and during exercise in congestive heart failure: comparison with clinical evaluation, ejection fraction, and exercise capacity. (9420653)
1995
40
Atrial natriuretic peptide in congestive heart failure after acute myocardial infarction. (8519004)
1993
41
Optimising ACE inhibitor therapy of congestive heart failure. Insights from pharmacodynamic studies. (8448973)
1993
42
Renal and electrolyte complications of congestive heart failure and effects of therapy with angiotensin-converting enzyme inhibitors. (1558426)
1992
43
Hormonal changes in patients with severe chronic congestive heart failure treated by ultrafiltration. (1317520)
1992
44
Beneficial effects of trandolapril on experimentally induced congestive heart failure in rats. (1414925)
1992
45
Cardiovascular and hormonal effects of calcitonin gene-related peptide in congestive heart failure. (1987228)
1991
46
Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure. (1720384)
1991
47
Role of atrial natriuretic peptide in congestive heart failure due to chronic diabetes. (1832580)
1991
48
Gamma 2-MSH in congestive heart failure: relation to atrial natriuretic peptide, arginine vasopressin and catecholamines. (2138208)
1990
49
Contracted form of primary endocardial fibroelastosis in a young adult without congestive heart failure. (3398240)
1988
50
On congestive heart failure after clinically healed subacute bacterial endocarditis. (18864134)
1948

Variations for Congestive Heart Failure

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Expression for genes affiliated with Congestive Heart Failure

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Congestive Heart Failure

Search GEO for disease gene expression data for Congestive Heart Failure.

Pathways for genes affiliated with Congestive Heart Failure

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 51PharmGKB, 30KEGG
See all sources

Pathways related to Congestive Heart Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9ADRA2C, ADRB1
29.8NPPB, NPPA
3
Show member pathways
9.7ACE, REN
4
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.5ADRB1, ACE, PLN
5
Show member pathways
9.2ADRB1, ADRA2C, UTS2, PLN
6
Show member pathways
Calcium Regulation in the Cardiac Cell38
9.1ADRB1, ADM, PLN
79.1ADM, ADRA2C, ADRB1
8
Show member pathways
8.6UTS2, ADM, ADRA2C, ADRB1

Compounds for genes affiliated with Congestive Heart Failure

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience
See all sources

Compounds related to Congestive Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1candoxatril45 1110.8ACE, NPPA, NPPB
2imidapril45 5110.7NPPB, NPPA, ACE
3ibopamine459.7ACE, REN, NPPA
4urodilatin459.7REN, NPPB, NPPA
5fenoldopam45 1110.7NPPA, REN, ADRA2C
6dobutamine45 29 51 1112.6NPPB, NPPA, ADRB1
7hanp459.6NPPA, NPPB, REN
8bucindolol45 5110.5ACE, REN, ADRA2C, ADRB1
9cilazapril45 1110.5NPPA, ACE, REN
10alacepril459.5NPPB, ACE, NPPA, REN
11trandolapril45 1110.5REN, NPPB, NPPA, ACE
12atenolol45 51 29 24 1113.5ADRB1, REN, NPPB, ACE
13fosinopril45 1110.4NPPA, NPPB, REN, ACE
14moxonidine459.4NPPA, NPPB, ACE, REN
15enalaprilat459.4NPPA, REN, ACE, NPPB
16lisinopril45 51 24 1112.4REN, ACE, NPPA, NPPB
17ramipril45 1110.4ACE, NPPA, NPPB, REN
18benazepril45 51 1111.4REN, NPPA, ACE
19perindopril45 51 1111.4NPPA, ACE, REN, NPPB
20amlodipine45 51 24 1112.4REN, ACE, NPPA, NPPB
21enalapril45 51 1111.4NPPB, REN, ACE, NPPA
22spironolactone45 61 29 51 1113.4REN, ACE, NPPA, NPPB
23digoxin45 61 51 24 1113.3REN, ACE, NPPA, NPPB
24furosemide45 61 29 51 24 1114.3NPPB, ACE, REN, NPPA
25quinapril45 51 1111.2NPPA, ACE, REN
26bisoprolol45 51 1111.2ADRB1, REN, NPPA, NPPB, ACE
27metoprolol45 51 29 24 1113.2NPPB, REN, ADRB1, ACE, NPPA
28omapatrilat459.0NPPA, ADM, REN, ACE
29phosphoramidon45 119.9NPPB, ADM, NPPA, ACE
30mibg458.9NPPA, ADM, NPPB, FABP3
31phenylephrine45 29 24 1111.7NPPA, NPPB, ADRB1, UTS2, ADM
32nitroglycerin45 119.6ACE, REN, NPPB, ADM, NPPA
33ang ii458.6ACE, REN, ADM, NPPB, NPPA
34captopril45 61 51 29 1112.6NPPB, ACE, REN, ADM, NPPA
35isoproterenol45 119.6ADRB1, ADM, REN, NPPA, NPPB
36losartan45 51 29 1111.6ACE, NPPA, NPPB, ADM, REN
37propranolol45 29 51 24 1112.5ADRB1, AMPD1, ADM, REN, NPPA
38catecholamine458.5ADRA2C, NPPB, NPPA, REN, ADRB1, ADM
39prostacyclin458.4ADM, REN, ACE, NPPA, NPPB
40carvedilol45 51 29 1111.4ADRB1, REN, ADM, NPPB, ACE, NPPA
41epinephrine45 24 1110.3ADRB1, REN, NPPA, ADM, NPPB
42forskolin45 51 1110.3ADRA2C, ADM, NPPA, NPPB, ADRB1, REN
43acetylcholine45 51 29 24 1112.2ACE, UTS2, VCL, ADM, NPPB
44sodium45 248.8ACE, REN, UTS2, ADRB1, ADM, NPPB
45creatinine457.6REN, FABP3, UTS2, NPPB, NPPA, ADM
46nitric oxide45 24 119.6ADRB1, NPPB, VCL, ACE, UTS2, ADM
47lipid457.4UTS2, ADM, NPPB, ADRB1, PLN, VCL
48norepinephrine45 24 119.1REN, ACE, NPPA, NPPB, FABP3, UTS2
49tyrosine456.9PDCD1, FABP3, UTS2, NPPB, ADRB1, ADM
50glucose456.9NPPB, AMPD1, VCL, ADRB1, ADM, UTS2

GO Terms for genes affiliated with Congestive Heart Failure

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Sources:
16Gene Ontology
See all sources

Cellular components related to Congestive Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5ADM, UTS2, REN, ACE, NPPA, NPPB
2extracellular spaceGO:0056156.8NPPB, ADM, UTS2, CBR3, REN, ACE

Biological processes related to Congestive Heart Failure according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle cell contractionGO:08600410.2ADRB1, PLN
2cGMP biosynthetic processGO:00618210.1NPPB, NPPA
3negative regulation of heart rateGO:01045910.1PLN, UTS2
4receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPB, NPPA
5regulation of calcium ion transportGO:05192410.1ADRB1, PLN
6negative regulation of urine volumeGO:03581110.1UTS2, ADRB1
7regulation of vasodilationGO:04231210.0ACE, NPPB
8regulation of blood vessel sizeGO:05088010.0NPPB, NPPA
9angiotensin maturationGO:0020039.9REN, ACE
10response to testosteroneGO:0335749.8UTS2, PLN
11regulation of the force of heart contractionGO:0020269.6ADM, PLN
12positive regulation of heart rateGO:0104609.4ADM, UTS2
13blood circulationGO:0080159.4PLN, ADM
14female pregnancyGO:0075659.3ADRA2C, ADM, NPPA
15response to coldGO:0094099.3ADRB1, ADM
16positive regulation of vasodilationGO:0459099.2UTS2, ADM
17response to insulinGO:0328689.1ADM, FABP3, NPPA
18positive regulation of cAMP biosynthetic processGO:0308199.1ADM, ADRB1
19response to hypoxiaGO:0016669.0NPPA, UTS2, ADM
20regulation of blood pressureGO:0082178.9NPPB, NPPA, ACE, REN, UTS2

Molecular functions related to Congestive Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:0513799.9ADRA2C, ADRB1
2alpha-2A adrenergic receptor bindingGO:0316949.6ADRA2C, ADRB1
3hormone activityGO:0051798.5NPPB, NPPA, UTS2, ADM
4receptor bindingGO:0051028.1ADM, UTS2, REN, NPPA, NPPB

Products for genes affiliated with Congestive Heart Failure

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congestive Heart Failure

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet