CHF
MCID: CNG034
MIFTS: 78

Congestive Heart Failure (CHF) malady

Cardiovascular diseases category
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Summaries for Congestive Heart Failure

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Fully expand this MalaCard
Disease Ontology:8 A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body.

MalaCards based summary: Congestive Heart Failure, also known as cardiac failure congestive, is related to central sleep apnea and mitral valve disease. An important gene associated with Congestive Heart Failure is PLN (phospholamban), and among its related pathways are Monoamine GPCRs and Cardiomyocyte Differentiation through BMP Receptors. The drugs captopril and enalapril and the compounds candoxatril and imidapril have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Congestive Heart Failure

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Congestive Heart Failure, Aliases & Descriptions:

Name: Congestive Heart Failure 30 8 10 62
Cardiac Failure Congestive 8
Heart Failure Congestive 44
Congestive Heart Disease 8
 
Heart Failure 62
Weak Heart 8
Chf 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Congestive Heart Failure

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Diseases related to Congestive Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1central sleep apnea31.9NPPB
2mitral valve disease31.7NPPA
3cor pulmonale31.1NPPA, NPPB
4myocarditis30.9NPPB, ADRB1
5syndrome of inappropriate antidiuretic hormone30.7NPPA, NPPB
6hypertensive heart disease30.7NPPB, NPPA, ACE
7mitral valve insufficiency30.7NPPB, NPPA
8aortic valve stenosis30.7NPPB, NPPA
9dilated cardiomyopathy30.7VCL, ADRB1, FABP3, ACE, PLN, NPPA
10chagas disease30.6NPPB, ADRB1
11diabetes mellitus30.5REN, ACE, NPPA, NPPB, UTS2
12hypokalemia30.5ACE, REN
13congenital heart disease30.5UTS2, NPPB, NPPA, ADM
14hyperaldosteronism30.5NPPA, ACE, REN
15pulmonary hypertension30.4ADM, UTS2, NPPB, NPPA, VCL
16hypertension30.4REN, UTS2, NPPA, NPPB, ACE, ADM
17kawasaki disease30.4NPPB, ADM
18cerebrovascular disease30.1ADM, ACE
19liver cirrhosis30.1REN, NPPA, UTS2, ADM
20type 2 diabetes mellitus30.1ACE, ADM, UTS2
21renovascular hypertension30.0ADM, REN, ACE, NPPA
22acute myocardial infarction29.9ACE, NPPA, UTS2, NPPB, ADM, ADRB1
23proteinuria29.9ADM, REN, ACE, UTS2
24ischemia29.8FABP3, ADM, VCL, NPPB, AMPD1
25myocardial infarction29.8REN, ADRB1, ADM, NPPB, NPPA, UTS2
26essential hypertension29.3ADRB1, ADM, UTS2, REN, ACE, NPPA
27sleep apnea10.8
28endotheliitis10.8
29peritonitis10.7
30blindness10.6
31artery disease10.6
32endocarditis10.6
33kidney disease10.6
34chronic obstructive pulmonary disease10.5
35pneumonia10.5
36hypoaldosteronism10.5REN
37oligohydramnios10.5ACE
38ischemic heart disease10.5
39right bundle branch block10.5
40subacute bacterial endocarditis10.5
41arteriovenous malformation10.5
42aneurysm10.5
43fibromuscular dysplasia10.5REN
44sick sinus syndrome10.4NPPA
45asthma10.4
46hepatitis10.4
47obesity10.4
48diastolic heart failure10.4
49acromegaly10.4
50hypertrophic cardiomyopathy10.4

Graphical network of the top 20 diseases related to Congestive Heart Failure:



Diseases related to congestive heart failure

Symptoms for Congestive Heart Failure

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Drugs & Therapeutics for Congestive Heart Failure

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Drug clinical trials:

Search ClinicalTrials for Congestive Heart Failure

Search NIH Clinical Center for Congestive Heart Failure

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Congestive Heart Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Congestive Heart Failure:
Adipose-derived stem cells for treatment of congestive heart failure
BMAC
Bone marrow-derived adult mononuclear cells for heart diseases
Cardiac progenitor cells for single-ventricle anomalies
Cardiosphere-derived autologous stem cells for reverse ventricular dysfunction
C-Cure
CD133+ bone marrow-derived stem cells in conjuction with coronary artery bypass grafting
CD34+ stem cells for treatment of congestive heart failure
Enriched bone marrow-derived progenitor cells for heart diseases
ERCs, endometrial regenerative cells for congestive heart failure
Human cardiac-derived stem cell for the treatment of congestive heart failure
Mesenchymal precursor cells for cardiovascular diseases
MyoCell
Peripheral or bone marrow-derived stem cells for chronic heart failure
Embryonic/Adult Cultured Cells Related to Congestive Heart Failure:
Adipose-derived mesenchymal stem cells (family)
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC), PMIDs: 15995108, 19896796, 18351022
Bone marrow-derived mononuclear cells, PMIDs: 22137069, 19699857, 20445812, 20524773
Cardiac progenitor cells, PMIDs: 18754813, 17502484, 14530411
Cardiac stem cells, PMIDs: 18754813, 17502484, 14530411
Cardiosphere-derived cells, PMID: 22336189
Cardiomyocyte-like cells, PMIDs: 23583247, 18835562
Bone marrow-derived CD133+ cells, PMID: 17320570
Bone marrow-derived hematopoietic stem cells (family), PMID: 22163120
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Endometrial regenerative cells , PMIDs: 18005405, 23510656, 20398245, 19232091
Human cardiac stem cells, PMIDs: 17502484, 19038683, 17150190
Mesenchymal Precursor Cells (STRO-3 selected), PMIDs: 20850099, 21155976
Skeletal myoblasts (MyoCell, PMIDs: 19051139, 15615560, 16446778
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565

Genetic Tests for Congestive Heart Failure

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Anatomical Context for Congestive Heart Failure

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MalaCards organs/tissues related to Congestive Heart Failure:

32
Heart, Bone, Brain, Endothelial, Kidney, Lung, Testes, Bone marrow, Liver, Skeletal muscle, Thyroid, Breast, Monocytes, Colon, Skin, Prostate, Myeloid, T cells, Cardiac myocytes, Pituitary, Neutrophil

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Congestive Heart Failure:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 Lateral Plate MesodermSplanchnic MesodermPericytes Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Congestive Heart Failure or affiliated genes

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MGI Mouse Phenotypes related to Congestive Heart Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3NPPA, PDCD1, ACE, REN, ADM
2MP:00053697.0VCL, ADRB1, ADM, FABP3, REN, PLN
3MP:00107686.9VCL, ADRB1, ADRA2C, ADM, FABP3, REN
4MP:00053766.9ADRB1, ADRA2C, ADM, FABP3, REN, ACE
5MP:00053856.4NPPB, VCL, ADRB1, ADRA2C, ADM, FABP3

Publications for Congestive Heart Failure

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Articles related to Congestive Heart Failure:

(show top 50)    (show all 1242)
idTitleAuthorsYear
1
Effective treatment of congestive heart failure using adaptive servo-ventilation in an end-stage renal disease patient on hemodialysis. (25224193)
2014
2
Congestive heart failure: an unusual presentation of pseudohypoparathyroidism. (23823262)
2013
3
Left Atrial Remodeling and Recurrence of Congestive Heart Failure in Patients Initially Diagnosed with Heart Failure. (24372958)
2013
4
Dynamic cardiac output regulation at rest, during exercise, and muscle metaboreflex activation: impact of congestive heart failure. (22855278)
2012
5
A case of unilateral pleural effusion secondary to congestive heart failure successfully treated with traditional Chinese herbal formulas. (22537563)
2012
6
Extracorporeal ultrafiltration for congestive heart failure patients. (21625112)
2011
7
Hospital discharge plan for patients with congestive heart failure. (22249681)
2011
8
A remote patient monitoring system for congestive heart failure. (21611788)
2011
9
Vitamin D deficiency in patients with congestive heart failure: mechanisms, manifestations, and management. (21606710)
2011
10
Cardiac status assessment with a multi-signal device for improved home-based congestive heart failure management. (22254450)
2011
11
N-terminal pro-b-type natriuretic peptide and left atrial function in patients with congestive heart failure and severely reduced ejection fraction. (21685193)
2011
12
Nurse-led self-management group programme for patients with congestive heart failure: randomized controlled trial. (20492026)
2010
13
Disease management 360 degrees: a scorecard approach to evaluating TRICARE's programs for asthma, congestive heart failure, and diabetes. (20613658)
2010
14
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
15
Discovery of new cardiovascular hormones for the treatment of congestive heart failure. (17346128)
2007
16
Significance of combined angiotensin II receptor blocker and carvedilol therapy in patients with congestive heart failure and arginine variant. (16475467)
2006
17
The significance of CA125 levels in patients with chronic congestive heart failure. Correlation with clinical and echocardiographic parameters. (15701467)
2005
18
Proinflammatory cytokines, soluble Fas receptor, nitric oxide and angiotensin converting enzyme in congestive heart failure. (16734138)
2005
19
Plasma B-type natriuretic peptide levels and risk factors for congestive heart failure in a Japanese general population. (16043942)
2005
20
Undertreatment of congestive heart failure in an Australian setting. (14748893)
2004
21
TNF and congestive heart failure: therapeutic possibilities. (15161427)
2004
22
Is hormonal activation during exercise useful for risk stratification in patients with moderate congestive heart failure? (15309008)
2004
23
Evidence for the survival benefit of neurohormonal antagonists in the management of geriatric congestive heart failure. (12688226)
2003
24
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
25
Patterns of pharmacologic treatment of congestive heart failure in elderly nursing home residents and related issues: a review of the literature. (12946542)
2003
26
Impact of pharmacotherapy on lymphocyte volumes and activity of the Na+/H+ exchanger in patients with congestive heart failure. (11771856)
2001
27
Endothelin A receptor antagonists in congestive heart failure: blocking the beast while leaving the beauty untouched? (11447305)
2001
28
Comparison of the first dose response of fosinopril and captopril in congestive heart failure: a randomized, double-blind, placebo controlled study. (11384079)
2001
29
Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure. (11181472)
2001
30
Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II). (11157688)
2001
31
Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. (11300427)
2001
32
Relationship between endothelin-1 extraction in the peripheral circulation and systemic vascular resistance in patients with severe congestive heart failure. (9973035)
1999
33
Improving outcomes in congestive heart failure: Val-HeFT. Valsartan in Heart Failure Trial. (10449891)
1999
34
Levels of adrenomedullin in plasma of patients with chronic congestive heart failure]. (9686497)
1998
35
Hemodynamic and neurohumoral effects of long-term prostaglandin E1 infusions in outpatients with severe congestive heart failure. (9171275)
1997
36
Pharmacology of carvedilol: rationale for use in hypertension, coronary artery disease, and congestive heart failure. (9211017)
1997
37
Effect of prolonged catecholamine infusion on immunoregulatory function: implications in congestive heart failure. (7797738)
1995
38
ACE inhibitors and calcium antagonists in the treatment of congestive heart failure. (8562467)
1995
39
Prognostic value of plasma catecholamines, plasma renin activity, and plasma atrial natriuretic peptide at rest and during exercise in congestive heart failure: comparison with clinical evaluation, ejection fraction, and exercise capacity. (9420653)
1995
40
Atrial natriuretic peptide in congestive heart failure after acute myocardial infarction. (8519004)
1993
41
Optimising ACE inhibitor therapy of congestive heart failure. Insights from pharmacodynamic studies. (8448973)
1993
42
Renal and electrolyte complications of congestive heart failure and effects of therapy with angiotensin-converting enzyme inhibitors. (1558426)
1992
43
Hormonal changes in patients with severe chronic congestive heart failure treated by ultrafiltration. (1317520)
1992
44
Beneficial effects of trandolapril on experimentally induced congestive heart failure in rats. (1414925)
1992
45
Cardiovascular and hormonal effects of calcitonin gene-related peptide in congestive heart failure. (1987228)
1991
46
Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure. (1720384)
1991
47
Role of atrial natriuretic peptide in congestive heart failure due to chronic diabetes. (1832580)
1991
48
Gamma 2-MSH in congestive heart failure: relation to atrial natriuretic peptide, arginine vasopressin and catecholamines. (2138208)
1990
49
Contracted form of primary endocardial fibroelastosis in a young adult without congestive heart failure. (3398240)
1988
50
On congestive heart failure after clinically healed subacute bacterial endocarditis. (18864134)
1948

Variations for Congestive Heart Failure

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Expression for genes affiliated with Congestive Heart Failure

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Expression patterns in normal tissues for genes affiliated with Congestive Heart Failure

Search GEO for disease gene expression data for Congestive Heart Failure.

Pathways for genes affiliated with Congestive Heart Failure

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Pathways related to Congestive Heart Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9ADRA2C, ADRB1
29.8NPPB, NPPA
3
Show member pathways
9.7ACE, REN
4
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.5ADRB1, ACE, PLN
5
Show member pathways
9.2ADRB1, ADRA2C, UTS2, PLN
6
Show member pathways
Calcium Regulation in the Cardiac Cell37
9.1ADRB1, ADM, PLN
79.1ADM, ADRA2C, ADRB1
8
Show member pathways
8.6UTS2, ADM, ADRA2C, ADRB1

Compounds for genes affiliated with Congestive Heart Failure

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Compounds related to Congestive Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
1candoxatril44 1110.8ACE, NPPA, NPPB
2imidapril44 5010.7NPPB, NPPA, ACE
3ibopamine449.7ACE, REN, NPPA
4urodilatin449.7REN, NPPB, NPPA
5fenoldopam44 1110.7NPPA, REN, ADRA2C
6dobutamine44 28 50 1112.6NPPB, NPPA, ADRB1
7hanp449.6NPPA, NPPB, REN
8bucindolol44 5010.5ACE, REN, ADRA2C, ADRB1
9cilazapril44 1110.5NPPA, ACE, REN
10alacepril449.5NPPB, ACE, NPPA, REN
11trandolapril44 1110.5REN, NPPB, NPPA, ACE
12atenolol44 50 28 24 1113.5ADRB1, REN, NPPB, ACE
13fosinopril44 1110.4NPPA, NPPB, REN, ACE
14moxonidine449.4NPPA, NPPB, ACE, REN
15enalaprilat449.4NPPA, REN, ACE, NPPB
16lisinopril44 50 24 1112.4REN, ACE, NPPA, NPPB
17ramipril44 1110.4ACE, NPPA, NPPB, REN
18benazepril44 50 1111.4REN, NPPA, ACE
19perindopril44 50 1111.4NPPA, ACE, REN, NPPB
20amlodipine44 50 24 1112.4REN, ACE, NPPA, NPPB
21enalapril44 50 1111.4NPPB, REN, ACE, NPPA
22spironolactone44 61 28 50 1113.4REN, ACE, NPPA, NPPB
23digoxin44 61 50 24 1113.3REN, ACE, NPPA, NPPB
24furosemide44 61 28 50 24 1114.3NPPB, ACE, REN, NPPA
25quinapril44 50 1111.2NPPA, ACE, REN
26bisoprolol44 50 1111.2ADRB1, REN, NPPA, NPPB, ACE
27metoprolol44 50 28 24 1113.2NPPB, REN, ADRB1, ACE, NPPA
28omapatrilat449.0NPPA, ADM, REN, ACE
29phosphoramidon44 119.9NPPB, ADM, NPPA, ACE
30mibg448.9NPPA, ADM, NPPB, FABP3
31phenylephrine44 28 24 1111.7NPPA, NPPB, ADRB1, UTS2, ADM
32nitroglycerin44 119.6ACE, REN, NPPB, ADM, NPPA
33ang ii448.6ACE, REN, ADM, NPPB, NPPA
34captopril44 61 50 28 1112.6NPPB, ACE, REN, ADM, NPPA
35isoproterenol44 119.6ADRB1, ADM, REN, NPPA, NPPB
36losartan44 50 28 1111.6ACE, NPPA, NPPB, ADM, REN
37propranolol44 28 50 24 1112.5ADRB1, AMPD1, ADM, REN, NPPA
38catecholamine448.5ADRA2C, NPPB, NPPA, REN, ADRB1, ADM
39prostacyclin448.4ADM, REN, ACE, NPPA, NPPB
40carvedilol44 50 28 1111.4ADRB1, REN, ADM, NPPB, ACE, NPPA
41epinephrine44 24 1110.3ADRB1, REN, NPPA, ADM, NPPB
42forskolin44 50 1110.3ADRA2C, ADM, NPPA, NPPB, ADRB1, REN
43acetylcholine44 50 28 24 1112.2ACE, UTS2, VCL, ADM, NPPB
44sodium44 248.8ACE, REN, UTS2, ADRB1, ADM, NPPB
45creatinine447.6REN, FABP3, UTS2, NPPB, NPPA, ADM
46nitric oxide44 24 119.6ADRB1, NPPB, VCL, ACE, UTS2, ADM
47lipid447.4UTS2, ADM, NPPB, ADRB1, PLN, VCL
48norepinephrine44 24 119.1REN, ACE, NPPA, NPPB, FABP3, UTS2
49tyrosine446.9PDCD1, FABP3, UTS2, NPPB, ADRB1, ADM
50glucose446.9NPPB, AMPD1, VCL, ADRB1, ADM, UTS2

GO Terms for genes affiliated with Congestive Heart Failure

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Cellular components related to Congestive Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5ADM, UTS2, REN, ACE, NPPA, NPPB
2extracellular spaceGO:0056156.8NPPB, ADM, UTS2, CBR3, REN, ACE

Biological processes related to Congestive Heart Failure according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of cardiac muscle cell contractionGO:08600410.2ADRB1, PLN
2cGMP biosynthetic processGO:00618210.1NPPB, NPPA
3negative regulation of heart rateGO:01045910.1PLN, UTS2
4receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPB, NPPA
5regulation of calcium ion transportGO:05192410.1ADRB1, PLN
6negative regulation of urine volumeGO:03581110.1UTS2, ADRB1
7regulation of vasodilationGO:04231210.0ACE, NPPB
8regulation of blood vessel sizeGO:05088010.0NPPB, NPPA
9angiotensin maturationGO:0020039.9REN, ACE
10response to testosteroneGO:0335749.8UTS2, PLN
11regulation of the force of heart contractionGO:0020269.6ADM, PLN
12positive regulation of heart rateGO:0104609.4ADM, UTS2
13blood circulationGO:0080159.4PLN, ADM
14female pregnancyGO:0075659.3ADRA2C, ADM, NPPA
15response to coldGO:0094099.3ADRB1, ADM
16positive regulation of vasodilationGO:0459099.2UTS2, ADM
17response to insulinGO:0328689.1ADM, FABP3, NPPA
18positive regulation of cAMP biosynthetic processGO:0308199.1ADM, ADRB1
19response to hypoxiaGO:0016669.0NPPA, UTS2, ADM
20regulation of blood pressureGO:0082178.9NPPB, NPPA, ACE, REN, UTS2

Molecular functions related to Congestive Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:0513799.9ADRA2C, ADRB1
2alpha-2A adrenergic receptor bindingGO:0316949.6ADRA2C, ADRB1
3hormone activityGO:0051798.5NPPB, NPPA, UTS2, ADM
4receptor bindingGO:0051028.1ADM, UTS2, REN, NPPA, NPPB

Products for genes affiliated with Congestive Heart Failure

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  • Antibodies
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Sources for Congestive Heart Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet