CHF
MCID: CNG034
MIFTS: 74

Congestive Heart Failure (CHF) malady

Cardiovascular category

Summaries for Congestive Heart Failure

Sources:
8Disease Ontology, 33MalaCards
See all sources

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Disease Ontology:8 A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount ofblood throughout the body.

MalaCards: Congestive Heart Failure, also known as cardiac failure congestive, is related to central sleep apnea and coronary heart disease. An important gene associated with Congestive Heart Failure is PLN (phospholamban), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs captopril and enalapril and the compounds nitric oxide and glucose have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and muscle.

Aliases & Classifications for Congestive Heart Failure

Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 61UMLS, 45Novoseek, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

congestive heart failure 8 10 31 61
cardiac failure congestive 8
congestive heart disease 8
heart failure congestive 45
heart failure 61
weak heart 8
chf 8


Related Diseases for Congestive Heart Failure

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Congestive Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 408)
idRelated DiseaseScoreTop Affiliating Genes
1central sleep apnea31.1NPPB
2coronary heart disease31.0EDN1, ACE, FABP3, NPY, ADRB1, ADRB2
3hypertensive heart disease30.8NPPB, ACE, NPPA
4acute myocardial infarction30.8NPPB, NPPA, FABP3, EDN1, ACE, UTS2
5coronary artery disease,30.8NPPB, NPPA, ADRB2, EDN1, ADRB1, ACE
6pulmonary disease, chronic obstructive30.7ADRB2
7insulin resistance30.7EDN1, FABP3, NPY, ADRB2, ACE, UTS2
8hypertension, diastolic30.7REN, ACE
9atherosclerosis30.6UTS2, ADRB2, TIMP4, EDN1, ACE
10asthma30.5ADRB2, ADM, EDN1
11hypoglycemia30.4ADRB2, NPY
12vascular disease30.4PLN
13pheochromocytoma30.4NPY, NPPA, UTS2, ADRB2, ADM
14sick sinus syndrome30.4NPPA
15septic shock30.2ADRB2, ADM, NPPB
16renovascular hypertension30.2REN, ADM, ACE, NPPA
17hypokalemia30.2ACE, ADRB2, REN
18kawasaki disease30.2ADM, NPPB
19alzheimer's disease30.2ADRB2, FABP3, NPY
20arthritis30.2TIMP4, ADRB2
21chagas disease30.2ADRB1, NPPB
22deficiency anemia30.2ACE, ADM
23familial hypertrophic cardiomyopathy30.2PLN
24arteriosclerosis30.2ADM, EDN1
25anorexia nervosa30.2NPY
26nephritis30.2ACE
27mitral valve insufficiency30.2NPPA, NPPB
28noonan syndrome30.0EDN1, ADRB1, ADRB2, VCL, PLN, NPPA
29diabetic nephropathy30.0ADM, REN, NPPA, EDN1, ACE, UTS2
30stroke, ischemic30.0NPPA, EDN1, ADM, ACE, REN
31primary pulmonary hypertension30.0ADM, NPPA, EDN1, NPPB
32systemic lupus erythematosus30.0PDCD1
33hepatorenal syndrome29.8REN, EDN1, NPPA
34primary hyperoxaluria29.8NPPA, ACE, NPY, EDN1
35cystic fibrosis29.8ADRB2
36syndrome of inappropriate antidiuretic hormone29.8NPPB, NPPA
37hypercholesterolemia29.8EDN1, ACE
38anuria29.8ACE
39sleep apnea10.8
40systolic heart failure10.7
41heart tumor10.7
42diastolic heart failure10.6
43n syndrome10.5
44arteriovenous malformation10.4
45heart aneurysm10.4
46subacute bacterial endocarditis10.4
47rheumatic congestive heart failure10.4
48acute myocarditis10.4
49cardiogenic shock10.4
50pulmonary edema10.4

Graphical network of the top 20 diseases related to Congestive Heart Failure:



Diseases related to congestive heart failure

Clinical Features for Congestive Heart Failure

Drugs & Therapeutics for Congestive Heart Failure

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Congestive Heart Failure

Drug clinical trials:

Search ClinicalTrials for Congestive Heart Failure

Search NIH Clinical Center for Congestive Heart Failure

Search CenterWatch for Congestive Heart Failure

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Congestive Heart Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Congestive Heart Failure:
Adipose-derived stem cells for treatment of congestive heart failure
BMAC
Bone marrow-derived adult mononuclear cells for heart diseases
Cardiac progenitor cells for single-ventricle anomalies
Cardiosphere-derived autologous stem cells for reverse ventricular dysfunction
C-Cure
CD133+ bone marrow-derived stem cells in conjuction with coronary artery bypass grafting
CD34+ stem cells for treatment of congestive heart failure
Enriched bone marrow-derived progenitor cells for heart diseases
ERCs, endometrial regenerative cells for congestive heart failure
Human cardiac-derived stem cell for the treatment of congestive heart failure
Mesenchymal precursor cells for cardiovascular diseases
MyoCell
Peripheral or bone marrow-derived stem cells for chronic heart failure
Embryonic/Adult Cultured Cells Related to Congestive Heart Failure:
Adipose-derived mesenchymal stem cells (family)
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC), PMIDs: 15995108, 19896796, 18351022
Bone marrow-derived mononuclear cells, PMIDs: 22137069, 19699857, 20445812, 20524773
Cardiac progenitor cells, PMIDs: 18754813, 17502484, 14530411
Cardiac stem cells, PMIDs: 18754813, 17502484, 14530411
Cardiosphere-derived cells, PMID: 22336189
Cardiomyocyte-like cells, PMIDs: 23583247, 18835562
Bone marrow-derived CD133+ cells, PMID: 17320570
Bone marrow-derived hematopoietic stem cells (family), PMID: 22163120
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Endometrial regenerative cells , PMIDs: 18005405, 23510656, 20398245, 19232091
Human cardiac stem cells, PMIDs: 17502484, 19038683, 17150190
Mesenchymal Precursor Cells (STRO-3 selected), PMIDs: 20850099, 21155976
Skeletal myoblasts (MyoCell, PMIDs: 19051139, 15615560, 16446778
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565

Genetic Tests for Congestive Heart Failure

Anatomical Context for Congestive Heart Failure

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Congestive Heart Failure:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 Lateral Plate MesodermSplanchnic MesodermPericytes Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Congestive Heart Failure or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Congestive Heart Failure:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.2ADRB2, TIMP4, PDCD1, NPPB, NPPA, FABP3
2MP:000536911.1ADRB2, ADM, ADRB1, VCL, PLN, REN
3MP:000537611.0ADRB2, REN, TIMP4, NPY, NPPA, FABP3
4MP:000536710.7ACE, PDCD1, NPY, NPPA, EDN1, REN
5MP:001076810.7ADM, ADRB1, TIMP4, VCL, ACE, PLN
6MP:000537510.7FABP3, ACE, ADRB1, ADRB2, NPY

Publications for Congestive Heart Failure

Sources:
51PubMed
See all sources

Articles related to Congestive Heart Failure:

(show top 50)    (show all 1227)
idTitleAuthorsYear
1
Predictors of Congestive Heart Failure after Treatment with an Endothelin Receptor Antagonist. (24408122)
2014
2
Which is more valuable, longer survival or better quality of life? Israeli oncologists' and family physicians' attitudes toward the relative value of new cancer and congestive heart failure interventions. (23947979)
2013
3
Reversal of cardiomyopathy in patients with congestive heart failure secondary to tachycardia. (23090777)
2013
4
Association between glycated haemoglobin and the risk of congestive heart failure in diabetes mellitus: systematic review and meta-analysis. (23099356)
2013
5
Improving quality of life and functional capacity in atrial fibrillation and congestive heart failure. (23541968)
2013
6
Negative feedback interaction of HO-1/INOS in PBMC of acute congestive heart failure patients. (24152841)
2013
7
Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure. (23973784)
2013
8
Secular trends in the etiology and comorbidity of hospitalized patients with congestive heart failure: A single-center retrospective study. (23341841)
2012
9
Serum positive for the autoantibody against the I^(1)-adrenoceptor from Chinese patients with congestive heart failure decreases I(ss) in mouse cardiac myocytes. (21716722)
2011
10
Deteriorated function of cutaneous microcirculation in chronic congestive heart failure. (22783290)
2011
11
Executive dysfunction and depressive symptoms associated with reduced participation of people with severe congestive heart failure. (21675336)
2011
12
Nurse-led self-management group programme for patients with congestive heart failure: randomized controlled trial. (20492026)
2010
13
Congestive heart failure. Don't forget rehabilitation. (20699311)
2010
14
A preclinical pharmacokinetic and pharmacodynamic approach to determine a dose of spironolactone for treatment of congestive heart failure in dog. (20557443)
2010
15
The development of congestive heart failure and ventricular tachycardia after first exposure to idarubicin in a patient with acute myeloid leukaemia. (20233187)
2010
16
The role of N-terminal pro-B-type natriuretic peptide in the diagnosis of congestive heart failure in children. - Correlation with the heart failure score and comparison with B-type natriuretic peptide -. (20378998)
2010
17
Congestive heart failure as presentation of acute lymphoblastic leukaemia with eosinophilia. (20148889)
2010
18
Computerized lung sound analysis following clinical improvement of pulmonary edema due to congestive heart failure exacerbations. (20529550)
2010
19
Congenital mitral stenosis, subvalvular aortic stenosis, and congestive heart failure in a duck. (18485855)
2008
20
Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure. (18313605)
2008
21
Serum levels of fatty acid-binding protein and brain natriuretic peptide in children with pneumonia complicated by acute congestive heart failure]. (18554454)
2008
22
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. (18096761)
2008
23
Glucose levels predict hospitalization for congestive heart failure in patients at high cardiovascular risk. (17339550)
2007
24
ACE inhibitors and mineralocorticoid receptor blockade in patients with congestive heart failure. (15663915)
2005
25
Superiority of big endothelin-1 and endothelin-1 over natriuretic peptides in predicting survival in severe congestive heart failure: a 7-year follow-up study. (15599839)
2004
26
Brain natriuretic peptide response is heterogeneous during beta-blocker therapy for congestive heart failure. (15309697)
2004
27
Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure. (15246912)
2004
28
Addition of valsartan to an angiotensin-converting enzyme inhibitor improves cardiac sympathetic nerve activity and left ventricular function in patients with congestive heart failure. (12791814)
2003
29
Congestive heart failure: what should be the initial therapy and why? (14727993)
2002
30
Effects of pentoxifylline on cytokine profiles and left ventricular performance in patients with decompensated congestive heart failure secondary to idiopathic dilated cardiomyopathy. (12423714)
2002
31
Alterations in immunocyte tumor necrosis factor receptor and apoptosis in patients with congestive heart failure. (12170032)
2002
32
Intact negative feedback of four cardiac hormones in congestive heart failure. (11979389)
2002
33
Endothelin A receptor antagonists in congestive heart failure: blocking the beast while leaving the beauty untouched? (11447305)
2001
34
Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II). (11157688)
2001
35
Propranolol treatment of congestive heart failure in infants with congenital heart disease: The CHF-PRO-INFANT Trial. Congestive heart failure in infants treated with propanol. (11461738)
2001
36
Effects of kaliuretic peptide on sodium and water excretion in persons with congestive heart failure. (11423053)
2001
37
Review of randomized trials of angiotensin receptor blockers in the treatment of patients with congestive heart failure]. (11676153)
2001
38
Value of brain natriuretic peptide in the diagnosis and treatment of congestive heart failure. (11173786)
2000
39
Beta-blocker treatment of dilated cardiomyopathy with congestive heart failure in children: a multi-institutional experience. (10328154)
1999
40
Protein-losing enteropathy in congestive heart failure: diagnosis by means of a simple method. (10430351)
1999
41
Inducible nitric oxide synthase (iNOS) in the human heart: expression and localization in congestive heart failure. (9689595)
1998
42
Increased plasma adrenomedullin levels in chronic congestive heart failure. (8615322)
1996
43
Effects of spirapril and captopril on regional blood flow in chronic congestive heart failure: a comparison between a short- and a long-acting angiotensin-converting enzyme inhibitor. (7723338)
1995
44
Calcium antagonists in the treatment of congestive heart failure]. (8286142)
1993
45
Medical advances in the treatment of congestive heart failure. (7902784)
1993
46
Determinants of the renal response to ACE inhibition in patients with congestive heart failure. (1615796)
1992
47
Electron spin resonance determination and superoxide dismutase activity in polymorphonuclear leukocytes in congestive heart failure. (1330241)
1992
48
Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure. (1914098)
1991
49
Successful surgical and anesthetic management of vein of Galen aneurysm in a neonate in congestive heart failure. (3380281)
1988
50
Congestive heart failure secondary to peripheral arteriovenous malformation. Klippel-Trenaunay syndrome. (189595)
1977

Genetic Variations for Congestive Heart Failure

Expression for genes affiliated with Congestive Heart Failure

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Congestive Heart Failure

Search GEO for disease gene expression data for Congestive Heart Failure.

Pathways for genes affiliated with Congestive Heart Failure

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore, 50PharmGKB, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Congestive Heart Failure

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Congestive Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1nitric oxide45 11 2413.5ACE, UTS2, VCL, REN, EDN1, NPPA
2glucose4511.5ACE, NPY, AMPD1, NPPB, ADRB1, ADM
3creatinine4511.4ADRB2, UTS2, ACE, REN, EDN1, NPPB
4carvedilol45 50 29 1114.3ACE, ADRB1, ADM, ADRB2, NPPB, NPPA
5epinephrine45 11 2413.3ADRB2, ADM, ADRB1, REN, NPPA, NPPB
6phenylephrine45 29 11 2414.3ADRB1, NPY, NPPB, ADM, NPPA, EDN1
7acetylcholine45 50 29 11 2415.2NPY, EDN1, VCL, ADRB2, ADM, UTS2
8catecholamine4511.2NPY, NPPB, NPPA, ADRB1, ADRB2, ADM
9bisoprolol45 50 1113.2ADRB2, NPPA, ADRB1, ACE, REN, NPPB
10metoprolol45 29 50 11 2415.2ACE, NPPB, NPPA, ADRB1, ADRB2, REN
11phosphoramidon45 1112.2ADM, NPY, NPPB, NPPA, ACE, EDN1
12nitroglycerin45 1112.2EDN1, ADM, ACE, REN, NPPA, NPPB
13prostacyclin4511.2NPPA, ACE, EDN1, REN, NPY, NPPB
14ang ii4511.2ADM, NPPA, EDN1, NPPB, REN, ACE
15norepinephrine45 11 2413.2ADRB1, UTS2, FABP3, NPY, ADM
16omapatrilat4511.2EDN1, REN, NPPA, ADM, ACE
17trandolapril45 1112.2ACE, REN, EDN1, NPPA, NPPB
18propranolol45 29 50 11 2415.2REN, ADRB2, ADM, ADRB1, NPPA, AMPD1
19losartan45 50 29 1114.2ACE, ADM, NPPB, NPPA, EDN1, REN
20forskolin45 50 1113.2REN, NPY, NPPA, ADRB1, NPPB, ADM
21enalaprilat4511.1REN, NPPA, ACE, NPPB, EDN1
22lisinopril45 11 2413.1REN, NPPB, NPY, NPPA, ACE
23sodium45 2412.1REN, EDN1, NPPA, ACE, UTS2, ADM
24atenolol45 29 50 11 2415.1NPPB, REN, ACE, ADRB1, ADRB2
25isoproterenol45 1112.1ADM, ADRB1, NPY, PDE3A
26enalapril45 50 1113.1ACE, NPPA, REN, EDN1, NPPB
27sodium nitroprusside4511.1NPY, NPPB, NPPA, EDN1, REN, ADM
28alacepril4511.1NPPB, ACE, NPPA, REN
29bucindolol50 4512.1ADRB1, ACE, REN, ADRB2
30verapamil45 50 29 11 2415.1UTS2, EDN1, REN, ADRB1, ACE, ADRB2
31urodilatin4511.0REN, EDN1, NPPA, NPPB
32captopril45 29 50 60 1115.0REN, EDN1, ADM
33nebivolol45 1112.0EDN1, ACE, ADRB1, ADRB2
34cilazapril45 1112.0REN, EDN1, NPPA, ACE
35hanp4511.0NPPA, NPPB, REN, EDN1
36cgmp45 2912.0PDE3A, NPPA, EDN1, NPPB, REN, ADM
37dobutamine45 29 1113.0NPPB, ADRB2, ADRB1, NPPA
38fosinopril45 1112.0REN, NPPB, NPPA, ACE
39moxonidine4511.0REN, ACE, NPPB, NPPA
40quinapril45 1111.9EDN1, NPPA, ACE, REN
41mibg4510.9ADM, NPPB, NPPA, FABP3
42ramipril45 1111.9ACE, REN, NPPA, NPPB
43thiorphan45 29 1112.9ACE, EDN1, NPPA, ADM
44valsartan45 60 29 1113.8ACE, REN, EDN1, NPPB
45dopexamine4510.7ADRB1, ADRB2, NPPA
46toki-shakuyaku-san4510.7REN, EDN1, NPPA
47ibopamine4510.6NPPA, REN, ACE
48candoxatril45 1111.6NPPB, NPPA, ACE
49perindopril45 50 1112.6REN, NPPA, ACE, NPPB
50enoximone45 1111.3NPPA, PDE3A, ADRB2

GO Terms for genes affiliated with Congestive Heart Failure

Sources:
16Gene Ontology
See all sources

Cellular components related to Congestive Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9NPY, NPPB, NPPA, EDN1, REN, ACE
2extracellular regionGO:00557610.7ADM, TIMP4, CALCB, NPY, NPPB, NPPA

Biological processes related to Congestive Heart Failure according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821711.1UTS2, ACE, REN, NPPA, NPPB, NPY
2elevation of cytosolic calcium ion concentrationGO:00720411.0EDN1, P2RY4, UTS2, ADM
3response to lipopolysaccharideGO:03249611.0ADM, REN, EDN1, TIMP4
4regulation of vasodilationGO:04231211.0NPPB, ACE, ADRB2
5positive regulation of heart rateGO:01046011.0ADM, UTS2, EDN1
6response to coldGO:00940911.0ADRB1, ADM, ADRB2
7blood circulationGO:00801510.9ADM, PLN, NPY
8response to insulin stimulusGO:03286810.9NPPA, FABP3, ADM
9vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.9ADRB2, ADRB1
10heat generationGO:03164910.9ADRB2, ADRB1
11negative regulation of urine volumeGO:03581110.9ADRB1, UTS2
12negative regulation of smooth muscle contractionGO:04598610.9ADRB2, ADRB1
13diet induced thermogenesisGO:00202410.8ADRB2, ADRB1
14negative regulation of heart rateGO:01045910.8PLN, UTS2
15cGMP biosynthetic processGO:00618210.8NPPA, NPPB
16regulation of cardiac muscle cell contractionGO:08600410.8ADRB1, PLN
17body fluid secretionGO:00758910.8EDN1, NPPB
18response to drugGO:04249310.8UTS2, FABP3, PDE3A, TIMP4
19negative regulation of vascular permeabilityGO:04311610.7PDE3A, ADM
20receptor guanylyl cyclase signaling pathwayGO:00716810.7NPPB, NPPA
21negative regulation of multicellular organism growthGO:04001510.6ADRB1, ADRB2
22regulation of blood vessel sizeGO:05088010.6NPPA, NPPB
23positive regulation of urine volumeGO:03581010.6NPPB, EDN1
24angiotensin maturationGO:00200310.5REN, ACE
25positive regulation of renal sodium excretionGO:03581510.3EDN1, NPPB

Molecular functions related to Congestive Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.6ADM, UTS2, EDN1, NPPA, NPPB
2norepinephrine bindingGO:05138010.6ADRB2, ADRB1
3receptor bindingGO:00510210.5NPY, NPPB, NPPA, REN, UTS2, ADM

Products for genes affiliated with Congestive Heart Failure

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Congestive Heart Failure

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet