Congestive Heart Failure malady

Genetics Home Reference: Congenital hepatic fibrosis is a disease of the liver that is present from birth. The liver has many important functions, including producing various molecules needed by the body and breaking down other molecules so that their components can be used or eliminated.¹⁷

MalaCards: Congestive Heart Failure, also known as cardiac failure congestive, is related to hypertension and systolic heart failure. An important gene associated with Congestive Heart Failure is PLN (phospholamban), and among its related pathways are Nuclear signaling by ERBB4 and Signaling Involved in Cardiac Hypertrophy. The drugs enalaprilat and nitroglycerin and the compounds norepinephrine and leucine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are digestive/alimentary and other.

Disease Ontology: A heart disease that is characterized by any structural or functional cardiacdisorder that impairs the ability of the heart to fill with or pump a sufficient amount ofblood throughout the body.⁶

Aliases & Descriptions:

congestive heart failure 6 43 cardiac failure congestive 6 congestive heart disease 6 heart failure congestive 32

heart failure 43 weak heart 6 chf 6

Diseases related to congestive heart failure by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1035)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	37.3	REN, CYP11B2, NOS2, NOS3, ACE, AGT
2	systolic heart failure	36.2	IL6, TNF, CYP11B2, NR3C2, CRP, EDN1
3	diastolic heart failure	35.3	MMP1, MMP9, NOS3, ACE, AGT, AGTR1
4	sleep apnea	34.2	RETN, NPPB, NPY, KNG1, ADRB2
5	pulmonary hypertension	33.5	PIK3CG, VCL, UTS2, ANGPT1, TEK, NOS2
6	constrictive pericarditis	31.2	REN, ALB, NPPB, ADA
7	familial hypertrophic cardiomyopathy	31.2	VCL, TPM1, TNNC1, TNNI3, TNNT2, PLN
8	cor pulmonale	31.1	REN, VWF, CAT, CALCA, EDN1, ACE
9	hepatitis	31.1	SELP, XDH, FAS, F2, ALB, TGFB1
10	hypertensive heart disease	30.9	CD36, MMP1, MMP9, AOC3, TPM1, CYP11B2
11	aldosteronism	30.9	PIK3CG, REN, RETN, NAGLU, VEGFA, UTS2
12	pericarditis	30.9	PIK3C2A, REN, IL6, ALB, TNF, TNNI3
13	muscular dystrophy	30.8	PIK3C2A, SGCD, LMNA, FKTN, DMD, ACTN2
14	achalasia	30.8	IL10, MC2R, TNF, PLN, NOS2, NOS3
15	ischemic heart disease	30.6	PIK3C2A, RETN, SELP, VCL, FABP3, ANGPT1
16	thyrotoxicosis	30.6	CD36, INS, IL2RA, ALB, CALCA, TTR
17	apnea	30.4	REN, RETN, VWF, SELE, SELP, LMNA
18	liver cirrhosis	30.3	REN, RETN, UTS2, XDH, AQP2, ANGPT2
19	adrenal hyperplasia	30.2	REN, CD36, INS, MC2R, IGF1, CYP11B2
20	twin twin transfusion syndrome	30.0	REN, VEGFA, B2M, ALB, EDN1, NPPA
21	iron deficiency anemia	29.9	SELP, XDH, ALB, CAT, TNF, SOD1
22	congenital heart defect	29.9	LMNA, KCNJ2, KCNQ1, GJA5, NPPA, NPPB
23	allergic asthma	29.8	PDE3B, SELE, IL10, IL2RA, CCL2, IFNG
24	hypocalcemia	29.8	PIK3C2A, CD36, ALB, CALCA, PTHLH, ADCY10
25	endocarditis	29.6	PIK3C2A, VWF, SELE, LMNA, MUC16, CD40LG
26	endocardial fibroelastosis	29.6	ACTN2, CSRP3, NPPA, NPPB, MYH7
27	crimean-congo hemorrhagic fever	29.6	VEGFA, IL6, F3, F2, TNF
28	atrial fibrillation	29.5	PIK3C2A, REN, RETN, VWF, SELE, SELP
29	poems syndrome	29.4	VEGFA, CD36, IL6, ALB, TNF, CRP
30	pulmonary edema	29.0	PIK3C2A, REN, VEGFA, INS, IL6, FAS
31	diphtheria	29.0	PIK3C2A, VEGFA, CD40LG, IL2RA, IL6R, IFNG
32	high blood pressure	29.0	REN, RETN, INS, ALB, NR3C2, NOS3
33	chronic obstructive pulmonary disease	28.9	XDH, MMP1, MMP9, IL6, CCL2, TRPV1
34	angioedema	28.9	MME, IL6, PLAT, ACE, AGT, AGTR2
35	septic shock	28.6	PIK3C2A, SELE, XDH, IL10, IL18R1, IL6
36	anemia	28.6	PDCD1, REN, VWF, SELE, SELP, NAGLU
37	autonomic dysfunction	28.5	REN, MME, INS, IL6, ALB, CRP
38	acromegaly	28.5	RETN, NAGLU, VEGFA, CD36, INS, IL6
39	autoimmune myocarditis	28.5	CCL2, IFNG, TNF, NOS2, AGTR1, NPPA
40	coronary stenosis	28.4	PIK3C2A, SELP, IL6, ICAM1, CRP, NOS3
41	coronary artery anomaly	28.1	PIK3C2A, RETN, VWF, SELE, SELP, LMNA
42	sleep disorder	27.8	INS, IL6, IL6R, IL6ST, ICAM1, ALB
43	patent ductus arteriosus	27.8	VEGFA, KCNA5, MMP1, MMP9, IL10, IL6
44	subacute sclerosing panencephalitis	27.8	MMP9, IL10, IL2RA, IL6, IFNG, TNF
45	pulmonary function	27.8	CD36, INS, IL10, IL6, IL6R, IFNG
46	ventricular septal defect	27.7	VEGFA, CITED2, IGF1, PSEN1, NPPA, NPPB
47	carcinoid syndrome	27.7	VEGFA, IGF1, CALCA, NPY, KNG1
48	childhood leukemia	27.7	CDKN3, IL2RA, ICAM1, TNF, NQO1, ABCB1
49	pulmonary embolism	27.7	PIK3C2A, INS, FABP3, F3, F2, ALB
50	aortic valve stenosis	27.6	VWF, CD36, MME, MMP9, CCL2, TNF

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amrinone, amrinone lactate, benazepril, benazepril hydrochloride, bendroflumethiazide, benzthiazide, bumetanide, candesartan, candesartan cilexetil, captopril, chlorothiazide, chlorothiazide sodium, chlorthalidone, coenzyme q10, cyclothiazide, enalapril, enalapril maleate, enalaprilat, eprosartan, eprosartan mesylate, ethacrynate sodium, ethacrynic acid, fenoldopam, fenoldopam mesylate, fosinopril, fosinopril sodium, furosemide, hydralazine, hydralazine hydrochloride, hydrochlorothiazide, hydroflumethiazide, inamrinone, inamrinone lactate, indapamide, isosorbide, isosorbide dinitrate, isosorbide mononitrate, lisinopril, losartan, losartan potassium, methyclothiazide, metolazone, milrinone, milrinone lactate, moexipril, moexipril hydrochloride, nitroglycerin, olmesartan, olmesartan medoxomil, perindopril, perindopril erbumine, polythiazide, quinapril, quinapril hydrochloride, quinethazone, ramipril, sodium nitroprusside, somatotropin, somatrem, somatropin, somatropin (recombinant dna origin), spironolactone, spironolactone pwdr [va product], telmisartan, torsemide, trandolapril, trichlormethiazide, valsartan

Cell-based therapeutics:

MalaCards organs/tissues related to congestive heart failure:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Lateral Plate Mesoderm -> Splanchnic Mesoderm -> Pericytes	Potential therapeutic candidate

MGI Mouse Phenotypes related to congestive heart failure:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary phenotype	MP:0005381	INF	VWF, VEGFA, VCL, , ,
2	other phenotype	MP:0005395	INF	, CD40LG, MME, FN1, ,
3	limbs/digits/tail phenotype	MP:0005371	INF	VEGFA, VCL, , , MMP9, FN1
4	embryogenesis phenotype	MP:0005380	INF	VCL, , , , IL6ST, F2
5	vision/eye phenotype	MP:0005391	INF	PDCD1, SELE, SELP, NAGLU, VEGFA,
6	growth/size phenotype	MP:0005378	INF	PIK3C2A, PIK3CG, PDE3B, REN, SELE, SELP
7	renal/urinary system phenotype	MP:0005367	INF	PDCD1, REN, SELP, NAGLU, ,
8	cellular phenotype	MP:0005384	INF	PIK3CG, PDCD1, VWF, SELE, SELP, NAGLU
9	skeleton phenotype	MP:0005390	INF	PIK3CG, NAGLU, VEGFA, , , JUN
10	hematopoietic system phenotype	MP:0005397	INF	PDCD1, , , P2RY6, CAPN1,
11	integument phenotype	MP:0010771	INF	PIK3CG, PDE3B, SELP, CHRM2, , XDH
12	nervous system phenotype	MP:0003631	INF	PDCD1, REN, VWF, SELP, NAGLU, VCL
13	normal phenotype	MP:0002873	INF	PDE3A, REN, SELE, VEGFA, ,
14	muscle phenotype	MP:0005369	INF	PIK3CG, PDCD1, REN, , VEGFA, VCL
15	endocrine/exocrine gland phenotype	MP:0005379	INF	, XDH, CD40LG, MC2R, IFNG,
16	tumorigenesis	MP:0002006	6.3	B2M, MMP9, FN1, IL10, IL6, IL6ST
17	liver/biliary system phenotype	MP:0005370	INF	RETN, VEGFA, CHRM2, , CD36, INS
18	respiratory system phenotype	MP:0005388	INF	SELP, , , CHRM2, , P2RY6
19	behavior/neurological phenotype	MP:0005386	INF	REN, SELE, SELP, NAGLU, ,
20	cardiovascular system phenotype	MP:0005385	INF	PIK3CG, PDCD1, REN, , VWF, SELE
21	immune system phenotype	MP:0005387	INF	REN, VWF, SELP, BSG, NAGLU,
22	adipose tissue phenotype	MP:0005375	INF	PIK3C2A, PDE3B, RETN, , , XDH
23	craniofacial phenotype	MP:0005382	INF	NAGLU, , , , EDN1, EDNRA
24	mortality/aging	MP:0010768	INF	PIK3C2A, PDCD1, REN, , VWF, SELE
25	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, PIK3CG, PDE3B, REN, RETN,
26	reproductive system phenotype	MP:0005389	INF	PDE3A, REN, VEGFA, , P2RX1, B2M
27	no phenotypic analysis	MP:0003012	INF	VEGFA, , P2RY6, INS, GNAI1,

Articles related to congestive heart failure:

(show top 50)    (show all 565)

id	Title	Authors	Year	Affiliating Genes
1	Soluble CD40L, platelet surface CD40L and total platelet CD40L in congestive heart failure: relationship to platelet volume, mass and granularity. (18086125)	Chung I.... Lip G.Y.	2008	CD40LG
2	Impact of ABCB1 (MDR1) gene polymorphism and P-glycoprotein inhibitors on digoxin serum concentration in congestive heart failure patients. (17377214)	Kurzawski M.... Drozdzik M.	2007	ABCB1
3	Cardiac troponin T vs other biochemical markers in patients with congestive heart failure. (17456983)	Nishio Y.... Kita T.	2007	REN, CRP, NPPB
4	Involvement of matrix metalloproteinases in the regulation of myocardial extracellular matrix in patients with congestive heart failure (16854324)	Yang Y.J.... Huang Y.	2006	FN1
5	Possible vascular role of increased plasma arginine v asopressin in congestive heart failure. (16321691)	Nakamura T.... Ishikawa S.E.	2006	NPPB, NPPA
6	Diagnostic value of the currently used criteria and brain natriuretic peptide for diagnosing congestive heart failure in children with congenital heart disease (17229370)	Wu Y.R.... Chen S.	2006	NPPB
7	Comparative cost-effectiveness of B-type natriuretic peptide and echocardiography for predicting outcome in patients with congestive heart failure. (16442404)	Dokainish H.... Nagueh S.F.	2006	NPPB
8	A case of ACTH-independent bilateral macronodular adrenal hyperplasia and severe congestive heart failure. (17185906)	Suri D.... Weiss R.E.	2006	POMC, MC2R
9	Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure. (15704065)	Arimoto T.... Kubota I.	2005	FABP3
10	The role of angiotensin-converting enzyme polymorphism in congestive heart failure. (15073454)	Pilati M.... Zardini P.	2004	ACE
11	Renal dysfunction in congestive heart failure, pathophysiological and prognostic significance. (15077868)	Cohen N.... Modai D.	2004	ACE
12	The use of contrast echocardiography in the diagnosis of an unusual cause of congestive heart failure: achalasia. (14961794)	Stoupakis G.... Saric M.	2004	PSAP
13	Role of adenosine monophosphate deaminase-1 gene polymorphism in patients with congestive heart failure (influence on tumor necrosis factor-alpha level and outcome). (15135700)	Gastmann A.... Figulla H.R.	2004	AMPD1
14	Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure. (15246912)	Dickstein K.... Koopman P.A.	2004	MME, ECE1
15	Recent advances in natriuretic peptides in congestive heart failure. (15174950)	Boerrigter G.... Burnett J.C.	2004	NPPB
16	Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosis. (12750023)	Hartmann R.W.... Ehmer P.B.	2003	CYP11B2
17	Development of congestive heart failure in type 2 diabetic patients with microalbuminuria or proteinuria: observations from the DIABHYCAR (type 2 DIABetes, Hypertension, CArdiovascular Events and Ramipril) study. (12610049)	Vaur L.... Passa P.	2003	ALB
18	Relation of circulating cardiac myosin light chain 1 isoform in stable severe congestive heart failure to survival and treatment with flosequinan. (12398964)	Hansen M.S.... Rouleau J.L.	2002	MYL3
19	Parathyroid hormone-related protein is produced in the myocardium and increased in patients with congestive heart failure. (12364464)	Ogino K.... Shigemasa C.	2002	PTHLH
20	Beneficial neurohormonal profile of spironolactone in severe congestive heart failure: results from the RALES neurohormonal substudy. (12427411)	Rousseau M.F.... Ketelslegers J.M.	2002	EDN1
21	Propranolol treatment of congestive heart failure in infants with congenital heart disease: The CHF-PRO-INFANT Trial. Congestive heart failure in infants treated with propanol. (11461738)	Buchhorn R.... BA1rsch J.	2001	REN
22	Plasma cardiac natriuretic peptides as biochemical markers of recurrence of atrial fibrillation in patients with mild congestive heart failure. (11059617)	Mabuchi N.... Kinoshita M.	2000	NPPB, NPPA
23	Relationship between endothelin-1 extraction in the peripheral circulation and systemic vascular resistance in patients with severe congestive heart failure. (9973035)	Tsutamoto T.... Kinoshita M.	1999	EDN1
24	Increased soluble platelet/endothelial cellular adhes ion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy. (10935670)	Serebruany V.L.... Gurbel P.A.	1999	PECAM1
25	Atrial natriuretic peptide and the development of congestive heart failure in the oldest old: a seven-year prospective study. (10203114)	Knight E.L.... Minaker K.L.	1999	NPPA
26	Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. (9462584)	Tsutamoto T.... Kinoshita M.	1998	IL6
27	Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. VEST Investigators for TNF Genotype Analysis. Vesnarinone Survival Trial. (9657468)	Kubota T.... Feldman A.M.	1998	TNF
28	Comparison of changes in respiratory function and exe rcise oxygen uptake with losartan versus enalapril in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. (9416938)	Guazzi M.... Agostoni P.	1997	ACE
29	Nonselective beta-adrenergic blockade with carvedilol does not hinder the benefits of exercise training in patients with congestive heart failure. (9107160)	Demopoulos L.... LeJemtel T.H.	1997	ACE
30	Clinical and neurohumoral differences between spirapr il and captopril in mild to moderate chronic congestive heart failure. (9330124)	van den Broek S.A.... Lie K.I.	1997	ACE
31	Direct selective blockade of the vascular angiotensin II receptors in therapy for hypertension and severe congestive heart failure. (8554006)	Awan N.A.... Mason D.T.	1996	KNG1
32	Plasma endothelin in congestive heart failure: effect of the ACE inhibitor, fosinopril. (9015418)	Galatius-Jensen S.... Kastrup J.	1996	ACE
33	Prevention of congestive heart failure by ACE inhibition in patients with acute myocardial infarction. (8749267)	Sigurdsson A.... Swedberg K.	1995	ACE
34	ACE inhibitors and calcium antagonists in the treatment of congestive heart failure. (8562467)	Hansen J.F.	1995	ACE
35	Elevation of circulating and ventricular adrenomedullin in human congestive heart failure. (7634439)	Jougasaki M.... Burnett J.C.	1995	ADM
36	Effects of spirapril and captopril on regional blood flow in chronic congestive heart failure: a comparison between a short- and a l ong-acting angiotensin-converting enzyme inhibitor. (7723338)	van den Broek S.A.... Lie K.I.	1995	ACE
37	Absence of hemodynamic tolerance to nicorandil in pat ients with severe congestive heart failure. (8154425)	Tsutamoto T.... Horie H.	1994	NPPA
38	Dose-related effects of ACE inhibition in man: quinapril in patients with moderate congestive heart failure. The Study Group on Neurohormonal Regulation in Congestive Heart Failure: Lausanne, Switzerland; Berlin, DA1sseldorf, Munich, Germany. (7713100)	Nussberger J.... Brunner H.R.	1994	ACE
39	Neurochemical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure. (8113536)	Kaye D.M.... Esler M.D.	1994	NPY
40	Responses of plasma concentrations of A type natriure tic peptide and B type natriuretic peptide to alacepril, an angiotensin-convert ing enzyme inhibitor, in patients with congestive heart failure. (7857734)	Yoshimura M.... Nakao K.	1994	NPPB, NPPA
41	Blood levels of erythropoietin in congestive heart failure and correlation with clinical, hemodynamic, and hormonal profiles. (8059727)	Volpe M.... Condorelli G.L.	1994	EPO
42	Atrial natriuretic peptide in congestive heart failure after acute myocardial infarction. (8519004)	Svanegaard J.... Pindborg T.	1993	NPPA
43	Elevated level of erythropoietin in congestive heart failure relationship to renal perfusion and plasma renin. (8433072)	Jensen J.D.... Pedersen E.B.	1993	EPO
44	Assessing the treatment of congestive heart failure: inotropic agents and calcium channel blockers. (7901842)	Hilleman D.E.	1993	ACE
45	Newer concepts in the medical management of patients with congestive heart failure. (8504571)	Weintraub N.L.... Chaitman B.R.	1993	ACE
46	Simultaneous modeling of the pharmacokinetic and phar macodynamic properties of enalkiren (Abbott-64662, a renin inhibitor). II: A do se-ranging study in patients with congestive heart failure. (7685457)	Gupta S.K.... Boger R.S.	1993	REN
47	Angiotensin-converting enzyme inhibitor and spironola ctone combination therapy. New objectives in congestive heart failure treatment . (8422003)	Zannad F.	1993	ACE
48	Maintenance of forearm vasodilator action of atrial natriuretic factor in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. (1533988)	Kubo S.H.... Cody R.J.	1992	NPPA
49	Pathophysiology of congestive heart failure. (1395215)	Parmley W.W.	1992	NPPA
50	Effects of bucindolol on neurohormonal activation in congestive heart failure. (1670902)	Eichhorn E.J.... Grayburn P.A.	1991	REN

Genes related to congestive heart failure according to GeneCards:

(show top 50)    (show all 135)

id	Symbol	Description	Score	GeneCards Section Context
1	PLN	phospholamban	11.1	Summaries
2	VCL	vinculin	11.1	Summaries
3	PDCD1	programmed cell death 1	11.0	Summaries
4	PDE3A	phosphodiesterase 3A, cGMP-inhibited	11.0	Summaries
5	ADRB1	adrenoceptor beta 1	11.0	Publications
6	ADRA2C	adrenoceptor alpha 2C	11.0	Publications
7	NPPA	natriuretic peptide A	11.0	Publications
8	NPPB	natriuretic peptide B	11.0	Publications
9	GUCA2B	guanylate cyclase activator 2B (uroguanylin)	11.0	Publications
10	CALCB	calcitonin-related polypeptide beta	11.0	Publications
11	CBR3	carbonyl reductase 3	11.0	Publications
12	AMPD1	adenosine monophosphate deaminase 1	11.0	Publications
13	STK16	serine/threonine kinase 16	11.0	Publications
14	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
15	UTS2	urotensin 2	11.0	Publications
16	REN	renin	11.0	Publications
17	ADM	adrenomedullin	11.0	Publications
18	ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	11.0	Publications
19	MYH4	myosin, heavy chain 4, skeletal muscle	11.0	Publications
20	TIMP4	TIMP metallopeptidase inhibitor 4	11.0	Publications
21	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	11.0	Publications
22	NPTXR	neuronal pentraxin receptor	11.0	Publications
23	MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	11.0	Publications
24	P2RY4	pyrimidinergic receptor P2Y, G-protein coupled, 4	11.0	Publications
25	NISCH	nischarin	11.0	Publications
26	AHSP	alpha hemoglobin stabilizing protein	11.0	Publications
27	EDN1	endothelin 1	11.0	Publications
28	CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	11.0	Publications
29	P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	11.0	Publications
30	P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	11.0	Publications
31	NPPC	natriuretic peptide C	11.0	Publications
32	AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	11.0	Publications
33	AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	11.0	Publications
34	EPO	erythropoietin	11.0	Publications
35	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	11.0	Publications
36	MYH6	myosin, heavy chain 6, cardiac muscle, alpha	11.0	Publications
37	ECE1	endothelin converting enzyme 1	11.0	Publications
38	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.0	Publications
39	CS	citrate synthase	11.0	Publications
40	ADORA1	adenosine A1 receptor	11.0	Publications
41	ADRB2	adrenoceptor beta 2, surface	11.0	Publications
42	NPY	neuropeptide Y	11.0	Publications
43	AGTR1	angiotensin II receptor, type 1	11.0	Publications
44	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
45	IL18R1	interleukin 18 receptor 1	11.0	Publications
46	ANGPT2	angiopoietin 2	11.0	Publications
47	IL6R	interleukin 6 receptor	11.0	Publications
48	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
49	PDYN	prodynorphin	11.0	Publications
50	MC2R	melanocortin 2 receptor (adrenocorticotropic hormone)	11.0	Publications

Pathways related to congestive heart failure according to GeneDecks:

(show top 50)    (show all 73)

id	Pathway	Score	Top Affiliating Genes
1	Nuclear signaling by ERBB438	INF	ADAM17, PGR, CXCL12, ,
2	Signaling Involved in Cardiac Hypertrophy36	INF	, ADRB1, ADRB2, , TGFB1, AGTR2
3	Hypertrophic cardiomyopathy (HCM)20	INF	TGFB1, , , ACE, ,
4	Dilated cardiomyopathy20	INF	MYL3, MYH7, MYH6, ADRB1, , TGFB1
5	Striated Muscle Contraction38	INF	MYL3, MYH6, , , ,
6	Antiarrhythmic Pathway, Pharmacodynamics34	INF	, PLN, , ADRB2, ADRB1, CHRM2
7	Molecular Mechanisms of Cancer36	INF	PPBP, TIMP4, TGFB1, , , CXCL12
8	Development_MAG-dependent inhibition of neurite outgrowth41	INF	MYL3, , , ADAM17, MYH4, MYH6
9	Activation of cAMP-Dependent PKA36	INF	PLN, NOS3, TIMP4, TGFB1, CXCL12, ADRB2
10	cAMP Pathway36	INF	PLN, NOS3, TIMP4, TGFB1, CXCL12, ADRB2
11	ACE Inhibitor Pathway, Pharmacodynamics34	10.8	AGTR2, AGTR1, ACE2, NR3C2, MME
12	Renin-angiotensin system20	10.8	AGTR2, AGTR1, AGT, ACE2, ACE, MME
13	Sympathetic Nerve Pathway (Neuroeffector Junction)34	10.7	ADM, ADRA2C, NPY, DBH, TH
14	Cell adhesion_Integrin inside-out signaling41	10.4	AGTR1, AGT, TBXA2R, FN1, PIK3CG
15	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.3	ACE2, ACE, NOS3, NR3C2, CYP11B2, MME
16	Neuroactive ligand-receptor interaction20	10.3	AGTR1, AGTR2, PRL, ADRB2, ADRA2C, ADORA1
17	Angiogenesis3	10.2	PECAM1, TGFB1, NOS3, PLN, TEK, ANGPT2
18	Cell surface interactions at the vascular wall38	9.8	THBD, F2, ANGPT1, ANGPT2, BSG, SELP
19	JNK Pathway36	9.7	CXCL12, TGFB1, TIMP4, PPBP, TEK, ANGPT1
20	Blood Coagulation Signaling Pathways37	9.7	THBD, PLAT, F2, F3, VWF, KNG1
21	Jak-STAT signaling pathway20	9.7	EPO, PRL, IL6ST, IL6R, IL2RA, IL10
22	Endothelin-1 Signaling Pathway36	9.6	ECE1, CSF3, CXCL12, EDNRA, EDN1, TEK
23	Akt Signaling36	9.6	ANGPT1, CCL2, TNF, TEK, TIMP4, CXCL12
24	Renin-Angiotensin Pathway36	9.5	AGT, AGTR1, AGTR2, TIMP4, TGFB1, CXCL12
25	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.5	SOD1, ABCB1, NOS3, NQO1, CAT, XDH
26	Doxorubicin Pathway, Pharmacokinetics34	9.4	SOD1, ABCB1, NOS3, NOS2, NQO1, CAT
27	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	TGFB1, TNF, FAS, IL2RA, IL10
28	Immune response_MIF-mediated glucocorticoid regulation41	9.3	MMP1, IL6, IFNG, ICAM1, TNF, NOS2
29	Immune response MIF-mediated glucocorticoid regulation10	9.3	NOS2, JUN, MMP1, IL6, IFNG, ICAM1
30	ERK Signaling36	9.0	PPBP, TIMP4, TGFB1, CXCL12, CSF3, TEK
31	STAT3 Pathway36	9.0	CCL2, TNF, TEK, CXCL12, CSF3, ANGPT1
32	Tec Kinases Signaling36	9.0	IGF1, TNF, TEK, PPBP, TIMP4, TGFB1
33	TGF-Beta Pathway36	9.0	CCL2, IGF1, PPBP, TIMP4, TGFB1, CXCL12
34	African trypanosomiasis20	8.9	TNF, ICAM1, IFNG, FAS, IL6, IL10
35	MAPK Family Pathway36	8.9	CCL2, IGF1, TNF, PPBP, TIMP4, TGFB1
36	PAK Pathway36	8.7	TIMP4, TGFB1, CXCL12, CSF3, MYH4, MYH6
37	p38 Signaling36	8.6	GNAI1, TNF, TEK, PPBP, TIMP4, TGFB1
38	Chagas disease (American trypanosomiasis)20	8.5	GNAI1, TNF, NOS2, ACE, TGFB1, IFNG
39	Antioxidant Action of Vitamin-C36	8.5	TEK, PPBP, TIMP4, TGFB1, CXCL12, CSF3
40	Malaria20	8.1	PECAM1, CSF3, TGFB1, TNF, ICAM1, IFNG
41	Rheumatoid arthritis20	8.0	ICAM1, TNF, TEK, TGFB1, CXCL12, IFNG
42	JAK-STAT Pathway36	7.9	TEK, PPBP, AGT, AGTR1, AGTR2, TIMP4
43	Cytokine-cytokine receptor interaction20	7.0	IFNG, TNF, PPBP, TGFB1, PRL, CXCL12
44	Amoebiasis20	INF	TGFB1, , NOS2, IL6, FN1, VCL
45	Activation of PKA through GPCR36	INF	PLN, NOS3, TIMP4, TGFB1, CXCL12, ADRB2
46	Rho Family GTPases36	INF	TEK, PPBP, TIMP4, TGFB1, , CXCL12
47	Cardiac muscle contraction20	INF	MYL3, MYH7, MYH6, , ,
48	Calcium signaling pathway20	INF	ADRB1, ADRB2, AGTR1, EDNRA, NOS3, NOS2
49	Epithelial Adherens Junctions36	INF	MYL3, MYH7, MYH6, MYH4, CXCL12, TIMP4
50	ILK Signaling36	INF	CXCL12, MYH4, MYH6, MYH7, MYL3, TIMP4

Compounds related to congestive heart failure according to GeneDecks:

(show top 50)    (show all 534)

id	Compound	Score	Top Affiliating Genes
1	norepinephrine32 9 18 9	INF	PIK3C2A, REN, RETN, VWF, SELE, SELP
2	leucine32	INF	NAGLU, , , JUN, MME, GUCA2B
3	alanine32	INF	PIK3C2A, PDE3A, RETN, VWF, SELE, NAGLU
4	glucose32	INF	VCL, MUC16, P2RY4, MME, IL18R1, ANGPT2
5	calcium32 9 18 9	INF	PIK3C2A, PDE3B, REN, RETN, VWF, NAGLU
6	nadph32 18	11.8	UTS2, AKR1D1, AGTR2, AHSP, DBH, OGDH
7	guanylate32	10.6	PDE3B, GUCA2B, ANGPT2, ANGPT1, PDE5A, AHSP
8	propranolol32 34 9 18 9	13.9	REN, CDKN3, MME, AMPD1, CALCA, PPBP
9	haloperidol32 34 9 9	12.9	PIK3C2A, REN, MMP1, IL18R1, AQP2, CYP11B2
10	gnrh32	9.9	CHRM2, MME, INS, CCL2, IGFBP1, IGF1
11	captopril32 42 9 9	12.9	REN, B2M, F3, ALB, CALCA, NR3C2
12	l-nmma32	9.8	XDH, CAT, NOS2, EDN1, EDNRA, AGT
13	apocynin32	9.8	SELE, XDH, JUN, ICAM1, CAT, NOS2
14	telmisartan32 9 9	11.7	REN, INS, ALB, CRP, ACE, AGT
15	atropine32 9 9	11.7	UTS2, CHRM2, MME, GNAI1, CALCA, PDYN
16	ascorbic acid32 18	10.6	PIK3CG, CD36, CD40LG, MME, IL2RA, FAS
17	aprotinin32 9 9	11.5	VWF, SELP, NAGLU, MMP9, FN1, IGF1
18	prostaglandin32	9.4	REN, MME, MMP1, MMP9, IL18R1, IL6
19	ibmx32	9.1	PDE3B, CDKN3, MME, FN1, INS, IGF1
20	lisinopril32 9 18 9	12.0	REN, VEGFA, MME, ALB, ABCB1, ACE
21	pioglitazone32 9 9	10.9	RETN, BSG, VEGFA, JUN, MMP1, MMP9
22	s-nitroso-n-acetylpenicillamine32	8.8	XDH, FN1, IFNG, CAT, NOS2, NOS3
23	guanine32 9 18 9	11.8	VWF, SELE, CHRM2, XDH, MMP1, MMP9
24	candesartan32 9 9	10.1	REN, SELP, VEGFA, MMP1, CCL2, ALB
25	perindopril32 34 9 9	10.8	REN, VWF, NAGLU, VEGFA, ALB, CRP
26	diphenyleneiodonium32	7.7	VEGFA, XDH, JUN, CDKN3, CCL2, ICAM1
27	okt332	7.6	SELE, CD40LG, IL10, IL18R1, IL2RA, IL6
28	pdtc32	7.6	PIK3CG, SELE, XDH, JUN, MMP1, MMP9
29	8-isoprostane32	7.2	RETN, SELE, XDH, MMP9, INS, IL10
30	acetylcholine32 9 18 9	INF	PIK3C2A, VWF, VCL, UTS2, CHRM2, CD40LG
31	vitamin a32 9 18 9	INF	RETN, VWF, NAGLU, B2M, MME, FAS
32	potassium32 9 18 9	INF	PIK3C2A, PDE3B, REN, NAGLU, ,
33	glycogen32 18	INF	PIK3C2A, PIK3CG, RETN, CDKN3, INS, IL6R
34	acth32	INF	PIK3C2A, PDE3B, REN, MME, INS, IL6
35	testosterone32 9 18 9	INF	PIK3C2A, SELE, VCL, MUC16, B2M, CD40LG
36	thromboxane a232 18	INF	PIK3C2A, VWF, SELP, NAGLU, P2RX1, GNAI1
37	fibrinogen32	INF	PIK3C2A, RETN, SELE, SELP, VCL, CD40LG
38	malondialdehyde32	INF	PIK3C2A, NAGLU, XDH, IL2RA, AOC3, CAT
39	sodium32 18	INF	PIK3C2A, REN, RETN, NAGLU, UTS2,
40	glutamate32	INF	BSG, P2RX1, CDKN3, MME, MMP9, INS
41	epinephrine32 9 18 9	INF	PIK3C2A, REN, SELE, SELP, , MMP1
42	thymidine32 18	INF	PDE3B, NAGLU, UTS2, B2M, JUN, MME
43	cysteine32	INF	PDE3A, SELP, NAGLU, VCL, UTS2,
44	arginine32	INF	PIK3C2A, REN, VWF, , ,
45	h2o232	INF	PIK3CG, VWF, NAGLU, UTS2, , MUC16
46	aspartate32	INF	PIK3C2A, RETN, SELP, NAGLU, , B2M
47	fenofibrate32 9 9	INF	PIK3C2A, RETN, SELE, SELP, CD40LG, MMP9
48	atp32	INF	PIK3C2A, PDE3B, VCL, , P2RX1, P2RY4
49	4-hydroxynonenal32 18	INF	XDH, JUN, MME, MMP1, IL10, FAS
50	prednisolone32 9 9	INF	PIK3C2A, VWF, MUC16, CDKN3, MMP1, IL10

Cellular components related to congestive heart failure according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:009986	INF	ABCB1, ACE2, THBD, TGFB1, ADA, ADAM17
2	cytosol	GO:005829	INF	, , , PDE5A, NISCH, RPS6
3	extracellular region	GO:005576	INF	KNG1, NPY, NPPC, NPPB, NPPA, PON1
4	membrane raft	GO:045121	9.6	ADAM17, ACE2, EDNRA, TEK, TNF, ANGPT1
5	external side of plasma membrane	GO:009897	8.6	ICAM1, TNF, ACE, CXCL12, ECE1, ADA
6	integral to plasma membrane	GO:005887	INF	THBD, AGTR2, AGTR1, EDNRA, TBXA2R,
7	extracellular space	GO:005615	INF	FN1, MMP9, CD40LG, B2M, MUC16, UTS2
8	neuronal cell body	GO:043025	INF	ADA, ADORA1, ADCY10, SOD1, DBH, TGFB1
9	sarcomere	GO:030017	INF	MYL3, MYH7, MYH6, MYH4, TIMP4,
10	plasma membrane	GO:005886	INF	PDYN, ANGPT1, ANGPT2, AOC3, FAS, MC2R
11	platelet alpha granule lumen	GO:031093	INF	KNG1, TGFB1, , PPBP, ALB, IGF1
12	Z disc	GO:030018	INF	MYH7, MYH6, , , ,
13	sarcolemma	GO:042383	INF	, , , , BSG,

Biological processes related to congestive heart failure according to GeneDecks:

(show top 50)    (show all 66)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular calcium ion homeostasis	GO:006874	INF	CXCL12, TGFB1, PLN, , CALCB, CCL2
2	cardiac muscle contraction	GO:060048	INF	MYL3, , , , ,
3	platelet activation	GO:030168	INF	, , PPBP, TBXA2R, GNAI1, ALB
4	heart development	GO:007507	INF	ADM, ECE1, NPPB, TH, EDNRA, EDN1
5	platelet degranulation	GO:002576	INF	VCL, VEGFA, SELP, VWF, CD36, FN1
6	cell-cell signaling	GO:007267	INF	POMC, PGR, ADRA2C, ADORA1, ADM,
7	muscle filament sliding	GO:030049	INF	, , , , , MYH7
8	sarcomere organization	GO:045214	INF	MYH6, , , ,
9	response to drug	GO:042493	INF	EDN1, CPT1A, NPPC, NPPB, SOD1, TGFB1
10	blood circulation	GO:008015	INF	EPO, ADM, NPY, CXCL12, PLN,
11	blood coagulation	GO:007596	INF	PIK3CG, THBD, , , PDE5A, NOS3
12	cell adhesion	GO:007155	INF	ADAM17, ADA, PECAM1, CXCL12, ,
13	ventricular cardiac muscle tissue morphogenesis	GO:055010	INF	MYL3, MYH7, MYH6, , ,
14	muscle contraction	GO:006936	INF	MYH7, MYH6, MYH4, , ,
15	regulation of vasoconstriction	GO:019229	10.9	ECE1, NPPC, AGTR1, AGT, ACE2, ACE
16	regulation of vasodilation	GO:042312	10.6	NPPB, AGTR1, ACE2, ACE
17	elevation of cytosolic calcium ion concentration	GO:007204	10.4	ADM, KNG1, AGTR1, EDNRA, EDN1, TBXA2R
18	vasodilation	GO:042311	10.4	KNG1, AGT, PDE5A, CALCA, CALCB
19	positive regulation of vasodilation	GO:045909	10.4	ADM, ADRB2, NPPC, AGTR2, NOS3, CALCA
20	positive regulation of cardiac muscle hypertrophy	GO:010613	10.4	AGT, EDN1, PDE5A, IGF1, IL6ST
21	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.3	AGTR1, AGT, ACE2, F2, CD36, XDH
22	regulation of blood pressure	GO:008217	10.2	MYH6, NPPC, NPPB, NPPA, POMC, SOD1
23	response to peptide hormone stimulus	GO:043434	10.1	NPPB, CXCL12, DBH, TIMP4, NOS3, PLAT
24	G-protein coupled receptor signaling pathway	GO:007186	9.9	ADRA2C, CXCL12, AGTR2, AGTR1, AGT, EDNRA
25	response to mechanical stimulus	GO:009612	9.8	CXCL12, NOS3, TNF, F3, CCL2, ANGPT2
26	positive regulation of MAPK cascade	GO:043410	9.7	ADRB2, AGT, IGF1, IL6R, IL6, INS
27	leukocyte migration	GO:050900	9.6	PECAM1, DBH, THBD, TEK, F2, ICAM1
28	response to lipopolysaccharide	GO:032496	9.5	EDN1, EDNRA, TIMP4, THBD, ADM, ADAM17
29	positive regulation of nitric oxide biosynthetic process	GO:045429	9.5	AGTR2, EDN1, TNF, ICAM1, IFNG, INS
30	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.5	AGT, TEK, CAT, F2, IGF1, ANGPT1
31	positive regulation of protein kinase B signaling cascade	GO:051897	9.5	TGFB1, TEK, TNF, F3, IGF1, ANGPT1
32	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	EDN1, TNF, IGF1, IL6R, IL6, JUN
33	aging	GO:007568	9.4	AGT, TGFB1, ADM, ADA, ADRB1, EPO
34	acute-phase response	GO:006953	9.3	CRP, F2, IL6R, IL6, INS, FN1
35	cell surface receptor signaling pathway	GO:007166	9.2	ADRB2, NPPB, PRL, AGTR2, EDN1, TRPV1
36	positive regulation of apoptotic process	GO:043065	9.1	AGTR2, SOD1, KNG1, ADRB2, ADCY10, AGT
37	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.9	AGT, IGF1, ANGPT1, IL6R, IL6, INS
38	inflammatory response	GO:006954	8.6	TBXA2R, CRP, AGTR2, TGFB1, NPPB, KNG1
39	small molecule metabolic process	GO:044281	INF	OGDH, DBH, PSAP, TH, AGT, ABCB1
40	blood vessel remodeling	GO:001974	INF	, DBH, AGTR2, AGT, NOS3, IGF1
41	negative regulation of apoptotic process	GO:043066	INF	TEK, EDNRA, CXCL12, , ADORA1, EPO
42	positive regulation of MAP kinase activity	GO:043406	INF	, TGFB1, EDN1, PDE5A, TNF, VEGFA
43	positive regulation of cell proliferation	GO:008284	INF	EDNRA, TGFB1, CSF3, , ADRB2, ADM
44	response to ethanol	GO:045471	INF	NPPC, SOD1, TH, , NOS3, ICAM1
45	regulation of the force of heart contraction	GO:002026	INF	MYL3, MYH6, , PDE5A, PLN, IFNG
46	negative regulation of cell proliferation	GO:008285	INF	NOS3, AGT, TGFB1, NPPC, ADORA1, ADM
47	anti-apoptosis	GO:006916	INF	TNF, TEK, NOS3, , SOD1, ADAM17
48	positive regulation of angiogenesis	GO:045766	INF	, ADM, NOS3, TBXA2R, TEK, F3
49	regulation of heart contraction	GO:008016	INF	MYH6, , TH, , , CHRM2
50	response to hypoxia	GO:001666	INF	UTS2, VEGFA, , ADAM17, ADA, ADM

Molecular functions related to congestive heart failure according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoskeletal protein binding	GO:008092	INF	, FABP3, CAPN1, , ,
2	structural constituent of muscle	GO:008307	INF	MYH4, MYH6, MYH7, MYL3, ,
3	protein homodimerization activity	GO:042803	INF	SOD1, PON1, NPPC, , ECE1, ADRB2
4	interleukin-6 receptor binding	GO:005138	10.4	ADAM17, IL6ST, IL6R, IL6
5	peptide hormone receptor binding	GO:051428	10.4	NPPC, NPPB, NPPA, PTHLH
6	drug binding	GO:008144	10.3	ADRB1, ADRB2, ACE, PPP3CA, ALB, P2RX1
7	hormone activity	GO:005179	9.5	PTHLH, EDN1, AGT, TTR, PRL, POMC
8	growth factor activity	GO:008083	7.8	AGT, TGFB1, CXCL12, CSF3, PPBP, F2
9	endopeptidase activity	GO:004175	INF	ECE1, , ACE2, ACE, MME
10	protein binding	GO:005515	INF	NOS2, , STK16, , , SOD1
11	receptor binding	GO:005102	INF	POMC, NPPA, NPPB, NPPC, NPY, PGR
12	calmodulin binding	GO:005516	INF	MYH7, MYH6, MYH4, , NOS3, NOS2