MCID: CNJ010
MIFTS: 24

Conjunctival Degeneration

Categories: Eye diseases

Aliases & Classifications for Conjunctival Degeneration

MalaCards integrated aliases for Conjunctival Degeneration:

Name: Conjunctival Degeneration 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10139
ICD10 32 H11.10
ICD9CM 34 372.50
SNOMED-CT 64 193886006 40787005
UMLS 69 C0155160

Summaries for Conjunctival Degeneration

MalaCards based summary : Conjunctival Degeneration is related to pinguecula and iris disease. An important gene associated with Conjunctival Degeneration is XPO4 (Exportin 4), and among its related pathways/superpathways are Acetaminophen Pathway (therapeutic doses), Pharmacokinetics and Nuclear Receptors in Lipid Metabolism and Toxicity. Affiliated tissues include eye, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Conjunctival Degeneration

Graphical network of the top 20 diseases related to Conjunctival Degeneration:



Diseases related to Conjunctival Degeneration

Symptoms & Phenotypes for Conjunctival Degeneration

MGI Mouse Phenotypes related to Conjunctival Degeneration:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.87 CYP1A1 DCLRE1C ITGB1 PAX6 TGM2 TP53
2 hematopoietic system MP:0005397 9.86 CD68 CYP1A1 DCLRE1C DHX9 ITGB1 TGM2
3 immune system MP:0005387 9.85 CD68 CYP1A1 DCLRE1C DHX9 ITGB1 MUC5AC
4 neoplasm MP:0002006 9.43 CYP2E1 ITGB1 PAX6 TGM2 TP53 XPA
5 pigmentation MP:0001186 8.92 ITGB1 PAX6 TP53 XPA

Drugs & Therapeutics for Conjunctival Degeneration

Search Clinical Trials , NIH Clinical Center for Conjunctival Degeneration

Genetic Tests for Conjunctival Degeneration

Anatomical Context for Conjunctival Degeneration

MalaCards organs/tissues related to Conjunctival Degeneration:

38
Eye

Publications for Conjunctival Degeneration

Articles related to Conjunctival Degeneration:

# Title Authors Year
1
Dietary I+-lipoic acid prevents UVB-induced corneal and conjunctival degeneration through multiple effects. ( 23989186 )
2013

Variations for Conjunctival Degeneration

Expression for Conjunctival Degeneration

Search GEO for disease gene expression data for Conjunctival Degeneration.

Pathways for Conjunctival Degeneration

GO Terms for Conjunctival Degeneration

Cellular components related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.8 CYP1A1 CYP2B6 CYP2E1

Biological processes related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.43 CYP1A1 CYP2B6 CYP2E1
2 response to antibiotic GO:0046677 9.4 CYP1A1 TP53
3 response to hyperoxia GO:0055093 9.37 CYP1A1 TP53
4 positive regulation of protein export from nucleus GO:0046827 9.32 TP53 XPO4
5 heterocycle metabolic process GO:0046483 9.16 CYP1A1 CYP2E1
6 drug metabolic process GO:0017144 9.13 CYP1A1 CYP2B6 CYP2E1
7 epoxygenase P450 pathway GO:0019373 8.8 CYP1A1 CYP2B6 CYP2E1

Molecular functions related to Conjunctival Degeneration according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.65 CYP1A1 CYP2B6 CYP2E1
2 heme binding GO:0020037 9.63 CYP1A1 CYP2B6 CYP2E1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.54 CYP1A1 CYP2B6 CYP2E1
4 damaged DNA binding GO:0003684 9.5 DCLRE1C TP53 XPA
5 histone acetyltransferase binding GO:0035035 9.49 PAX6 TP53
6 arachidonic acid epoxygenase activity GO:0008392 9.43 CYP2B6 CYP2E1
7 monooxygenase activity GO:0004497 9.43 CYP1A1 CYP2B6 CYP2E1
8 oxygen binding GO:0019825 9.33 CYP1A1 CYP2B6 CYP2E1
9 steroid hydroxylase activity GO:0008395 9.13 CYP1A1 CYP2B6 CYP2E1
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.8 CYP1A1 CYP2B6 CYP2E1
11 metal ion binding GO:0046872 10.06 CRYAA CYP1A1 CYP2B6 CYP2E1 DHX9 ITGB1

Sources for Conjunctival Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....