MCID: CNJ013
MIFTS: 62

Conjunctivitis malady

Eye diseases category
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Summaries for Conjunctivitis

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Disease Ontology:8 Conjunctivitis is a conjunctival disease described as a inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids, which is most commonly due to an allergic reaction or an infection (usually viral, but sometimes bacterial. fungal infections are rare and occur mainly in people who use corticosteroid eye drops for a long time or have eye injuries involving vegetable matter. newborns are particularly susceptible to eye infections, which they acquire from organisms in the mother's birth canal (neonatal conjunctivitis.

MalaCards based summary: Conjunctivitis is related to giant papillary conjunctivitis and allergic conjunctivitis. An important gene associated with Conjunctivitis is PLG (plasminogen), and among its related pathways are amb2 Integrin signaling and Matrix Metalloproteinases. The drugs cromolyn sodium and oxymetazoline and the compounds unicap and lte4 have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:65 Conjunctivitis (also called pink eye in North America or Madras eye in India) is inflammation of the... more...

Aliases & Classifications for Conjunctivitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
See all sources

Conjunctivitis, Aliases & Descriptions:

Name: Conjunctivitis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:6195
ICD9CM27 372.30
NCIt39 C34504
MeSH34 D003231

Related Diseases for Conjunctivitis

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Diseases in the Conjunctivitis family:

Acute Conjunctivitis Bacterial Conjunctivitis
Chronic Conjunctivitis

Diseases related to Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 406)
idRelated DiseaseScoreTop Affiliating Genes
1giant papillary conjunctivitis31.4RNASE3, CCL11, IL5
2allergic conjunctivitis31.1RNASE3, CCL11, IL4, IL5, IL13
3dysplasminogenemia30.7PLG, ELANE
4uveitis30.4IL4, CCL11
5asthma30.4CCL11, IL13
6otitis media30.3RNASE3, CCL11
7keratoconjunctivitis30.3RNASE3, CCL11, IL5, IL13
8pneumonia30.1IL13, IL5, CCL11, ELANE
9dermatitis30.0CCL11, IL4, IL5, IL13
10arthritis29.9FCER2, IL4, IL13, PLG
11urticaria29.9RNASE3, FCER2
12kawasaki disease29.9FCER2, ELANE
13sinusitis29.9RNASE3, CCL11, IL5
14vernal keratoconjunctivitis29.8RNASE3, CCL11, IL4, IL5, IL13
15leukemia29.7FCER2, RNASE3, CCL11, IL4, PLG
16atherosclerosis29.5PLG, CCL11, ELANE
17rhinitis29.5FCER2, RNASE3, CCL11, IL4, IL5, IL13
18sarcoidosis29.5FCER2, CCL11, IL13
19nephrotic syndrome29.4CCL11, IL13
20allergic rhinitis29.4FCER2, RNASE3, CCL11, IL4, IL5, IL13
21atopic dermatitis29.3FCER2, RNASE3, CCL11, IL4, IL13
22inflammatory bowel disease29.3ELANE, CCL11, IL4, IL13
23eosinophilia29.0IL13, IL5, IL4, CCL11, RNASE3, FCER2
24bullous pemphigoid28.9FCER2, RNASE3, CCL11, IL5, IL13
25rheumatoid arthritis28.7FCER2, RNASE3, ELANE, CCL11, IL4, IL13
26bacterial conjunctivitis10.9
27papillary conjunctivitis10.8
28inclusion conjunctivitis10.8
29acute hemorrhagic conjunctivitis10.8
30acute conjunctivitis10.7
31vernal conjunctivitis10.7
32chronic conjunctivitis10.7
33trachoma10.6
34folliculitis10.5CCL11
35blindness10.5
36aspergillosis10.4ELANE
37paragonimiasis10.4IL5
38malaria10.4FCER2
39keratitis10.4
40blepharitis10.4
41strongyloidiasis10.4IL5
42ophthalmia neonatorum10.3
43common cold10.3RNASE3, CCL11
44chronic follicular conjunctivitis10.3
45eosinophilic esophagitis10.3IL5, CCL11
46autosomal dominant hyper ige syndrome10.3RNASE3, IL4
47kimura disease10.3RNASE3, IL5
48conjunctivitis ligneous10.2
49conjunctivitis with pseudomembrane10.2
50eosinophilic gastroenteritis10.2CCL11, IL5

Graphical network of the top 20 diseases related to Conjunctivitis:



Diseases related to conjunctivitis

Symptoms for Conjunctivitis

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Drugs & Therapeutics for Conjunctivitis

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Genetic Tests for Conjunctivitis

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Anatomical Context for Conjunctivitis

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MalaCards organs/tissues related to Conjunctivitis:

32
Eye, Testes, T cells, Bone, Prostate, Bone marrow, Colon, Lung, Endothelial, Kidney, Breast, Skin, Lymph node, Liver, Brain, Spinal cord, Heart, Small intestine, Thyroid, Ovary, Myeloid, Monocytes, B cells, Pituitary, Neutrophil

Animal Models for Conjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Conjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9CCL11, IL4, IL5, IL13, PLG
2MP:00053817.4FCER2, IL4, IL5, IL13, PLG
3MP:00053767.2PLG, IL13, IL5, IL4, ELANE, FCER2
4MP:00053976.9PLG, FCER2, ELANE, CCL11, IL4, IL5
5MP:00053876.8FCER2, ELANE, CCL11, IL4, IL5, IL13

Publications for Conjunctivitis

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Articles related to Conjunctivitis:

(show top 50)    (show all 1667)
idTitleAuthorsYear
1
Chronic Conjunctivitis due to Nocardia nova Complex Formation on a Silicone Stent: A Case Report and Review of the Literature. (24892274)
2014
2
Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer. (24420556)
2014
3
Genetic characteristics of the coxsackievirus A24 variant causing outbreaks of acute hemorrhagic conjunctivitis in Jiangsu, China, 2010. (24475191)
2014
4
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. (23092529)
2013
5
Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. (23212114)
2013
6
Understanding the origin of seasonal epidemics of mycoplasmal conjunctivitis. (22524311)
2012
7
Lichen planus and cicatricial conjunctivitis: disease course and response to therapy of 11 patients. (20477930)
2011
8
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
9
Detection of Chlamydophila caviae and Streptococcus equi subsp. zooepidemicus in horses with signs of rhinitis and conjunctivitis. (19913370)
2010
10
Increasing case numbers of adenovirus conjunctivitis in Germany, 2010. (21087592)
2010
11
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. (20523096)
2010
12
Occupational conjunctivitis as the sole manifestation of airborne contact allergy to trimethylolpropane triacrylate contained in a UV-cured paint. (19076890)
2008
13
Association between beta2 adrenergic receptor polymorphisms and rheumatoid arthritis in conjunction with human leukocyte antigen (HLA)-DRB1 shared epitope. (18267980)
2008
14
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. (17680326)
2007
15
Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. (17701212)
2007
16
Management of acute conjunctivitis in school-aged children. (17410958)
2007
17
Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis. (17560570)
2007
18
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
19
Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase. (15557278)
2005
20
Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2. (15507617)
2004
21
Coccidiosis control with toltrazuril in conjunction with anticoccidial medicated or nonmedicated feed. (12887207)
2003
22
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
23
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. (12941273)
2003
24
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
25
Vascular permeability in allergic conjunctivitis in mice lacking histamine H1 receptors. (11108826)
2000
26
Mitomycin-C and vernal conjunctivitis. (11097580)
2000
27
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
28
The role of IL-12 in the induction of late-phase cellular infiltration in a murine model of allergic conjunctivitis. (10669851)
2000
29
Demineralization inhibition at glass-ionomer cement and amalgam restoration margins in conjunction with additional fluoride regimens. (10483457)
1999
30
Dry eye in allergic conjunctivitis: role of inflammatory infiltrate. (12783641)
1999
31
Conjunction dysfunction: CBP/p300 in human disease. (9613201)
1998
32
Dose-dependent protection by azelastine eye drops against pollen-induced allergic conjunctivitis. A double-blind, placebo-controlled study. (9608880)
1998
33
Allergic conjunctivitis from eyedrops. (9226074)
1997
34
Index of suspicion. Case 2. Diagnosis: gonorrhea conjunctivitis. (9114719)
1997
35
Detection of serum antibodies to Chlamydia pneumoniae in patients with endogenous uveitis and acute conjunctivitis. (9356816)
1997
36
Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis. (8919742)
1996
37
Levocabastine eye drops in vernal conjunctivitis. (8963170)
1995
38
Double-blind trial of pentigetide ophthalmic solution, 0.5%, compared with cromolyn sodium, 4%, ophthalmic solution for allergic conjunctivitis. (1903616)
1991
39
Expressive therapy in conjunction with psychotherapy in the treatment of persons with multiple personality disorder. (2252072)
1990
40
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
41
Acute hemorrhagic conjunctivitis--Mexico. (2540410)
1989
42
An epidemic of acute hemorrhagic conjunctivitis in the city of Sao Paulo. (2834590)
1987
43
Tear film flow and stability in acute and chronic conjunctivitis. (3618153)
1987
44
A double-blind crossover study comparing sodium cromoglycate eye drops with placebo in the treatment of chronic conjunctivitis. (6431741)
1984
45
Recurrent conjunctivitis in neonatal herpes infection. (6889160)
1983
46
Synergistic antiviral effects of interferon plus antibody against acute hemorrhagic conjunctivitis viruses, herpes virus and adenovirus. (6189220)
1981-1982
47
An epidemic of acute conjunctivitis caused by enterovirus-70 in Singapore in 1980. (6283679)
1981
48
An outbreak of acute conjunctivitis caused by coxsackievirus A24 in Kuala-Lumpur, Malaysia, 1978. (6250226)
1980
49
Intrarectal infection of guinea pigs with the agent of guinea pig inclusion conjunctivitis. (1013148)
1976
50
Acute conjunctivitis and moraxella. (5338673)
1967

Variations for Conjunctivitis

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Expression for genes affiliated with Conjunctivitis

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Expression patterns in normal tissues for genes affiliated with Conjunctivitis

Search GEO for disease gene expression data for Conjunctivitis.

Pathways for genes affiliated with Conjunctivitis

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Pathways related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6PLG, ELANE
2
Show member pathways
9.6PLG, ELANE
3
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.5IL5, IL4
49.5IL4, IL5
59.1CCL11, IL4, IL5
6
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.0FCER2, CCL11, IL4
78.9IL5, IL4, FCER2
8
Show member pathways
8.9PLG, IL13, IL4
9
Show member pathways
Type III interferon signaling37
8.7IL4, IL5, IL13
10
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.7IL13, IL5, IL4
11
Show member pathways
8.7IL4, IL5, IL13
128.7IL13, IL5, IL4
138.7IL4, IL5, IL13
148.7IL13, IL5, IL4
158.7IL4, IL5, IL13
168.7IL13, IL5, IL4
178.5FCER2, CCL11, IL4, IL5
18
Show member pathways
8.3CCL11, IL4, IL5, IL13
19
Show member pathways
8.3IL13, IL5, IL4, CCL11
20
Show member pathways
8.3CCL11, IL4, IL5, IL13
21
Show member pathways
8.3CCL11, IL4, IL5, IL13
22
Show member pathways
7.9IL13, IL5, IL4, CCL11, RNASE3
23
Show member pathways
7.7IL13, IL5, IL4, CCL11, FCER2

Compounds for genes affiliated with Conjunctivitis

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Compounds related to Conjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1unicap449.5RNASE3, CCL11, IL5
2lte4449.5IL5, RNASE3, CCL11
3sodium cromoglycate449.5RNASE3, CCL11, IL5
4cetirizine44 28 24 1112.4CCL11, IL5, RNASE3
5ketotifen44 1110.3RNASE3, CCL11, IL5
6azelastine44 1110.2IL5, RNASE3, IL4
7pranlukast44 28 1111.1IL4, IL5, CCL11, RNASE3
8formoterol44 28 1111.1IL4, IL13, RNASE3
9omalizumab44 1110.0IL4, IL13, IL5
10n-formylmethionyl-leucylphenylalanine449.0IL5, CCL11, ELANE, RNASE3
11glatiramer acetate44 119.9IL4, IL5, IL13
12nedocromil sodium448.9IL5, RNASE3, IL4, FCER2
13amphotericin b448.8IL13, IL5, IL4
14ltd4448.8RNASE3, IL5, IL13
15ltc4448.7IL13, IL5, CCL11, RNASE3
16pgd2448.7IL13, IL5, CCL11, RNASE3
17praziquantel44 119.7IL13, IL4, RNASE3, IL5
18il-12448.7IL13, IL4, IL5
19tarc448.7CCL11, IL4, IL5, IL13
20ovomucoid448.6IL13, ELANE, IL5, IL4
21prednisolone44 28 1110.6IL13, RNASE3, IL5, CCL11
22gm-csf44 289.5ELANE, IL13, IL5, IL4
23herbimycin a44 619.4IL5, IL4, CCL11, FCER2
24hyaluronic acid44 249.3CCL11, RNASE3, IL13, ELANE
25salmeterol44 50 28 1111.3CCL11, IL4, IL13, RNASE3, IL5
26montelukast44 50 28 1111.3RNASE3, IL5, IL13, CCL11, IL4
27budesonide44 50 1110.3CCL11, IL4, IL5, RNASE3, IL13
28methacholine44 50 1110.3CCL11, IL4, IL5, IL13, RNASE3
29aspirin44 50 28 2411.3CCL11, RNASE3, ELANE, IL4, IL13
30rantes448.2CCL11, IL4, IL5, IL13, RNASE3
31rolipram44 61 2810.2CCL11, IL5, IL13, ELANE, IL4
32salbutamol44 50 28 24 1112.2RNASE3, CCL11, IL13, IL5, FCER2
33ionomycin448.1IL13, IL5, IL4, CCL11, FCER2
34sb 20358044 619.0IL4, IL5, IL13, CCL11, FCER2
35hydrocortisone44 2 61 1110.9FCER2, ELANE, IL4, IL5, IL13
36vegf447.9CCL11, RNASE3, IL4, IL5, PLG, IL13
37heparin44 28 24 1110.9PLG, IL13, IL5, CCL11, ELANE, RNASE3
38thyroxine44 248.9IL13, ELANE, IL5, IL4
39fluticasone propionate44 50 61 1110.8IL13, CCL11, ELANE, IL4, RNASE3, IL5
40cyclosporin a44 28 619.8RNASE3, ELANE, CCL11, IL5, IL13, IL4
41thymidine44 248.7PLG, FCER2, CCL11, IL4, IL5, IL13
42allergens447.7IL4, IL5, RNASE3, FCER2, CCL11, IL13
43histamine44 28 249.7RNASE3, CCL11, IL4, FCER2, IL5, IL13
44leukotriene b444 61 249.6RNASE3, ELANE, IL5, CCL11, FCER2, IL13
45fmlp447.6IL13, IL5, CCL11, ELANE, RNASE3, FCER2
46dexamethasone44 50 28 1110.6RNASE3, IL4, IL5, IL13, CCL11, FCER2
47retinoic acid44 248.5CCL11, ELANE, RNASE3, IL5, IL13, FCER2
48cysteine447.4IL13, ELANE, IL5, FCER2, IL4, PLG
49tyrosine447.2IL4, PLG, IL13, RNASE3, FCER2, CCL11
50pge2447.2ELANE, CCL11, IL4, RNASE3, FCER2, IL13

GO Terms for genes affiliated with Conjunctivitis

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Cellular components related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6IL13, IL4, FCER2
2extracellular spaceGO:0056157.7CCL11, IL4, IL5, IL13, PLG
3extracellular regionGO:0055767.4PLG, IL13, IL5, CCL11, ELANE, RNASE3

Biological processes related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular calcium ion homeostasisGO:0068749.6CCL11, ELANE
2regulation of proton transportGO:0101559.2IL4, IL13
3positive regulation of smooth muscle cell proliferationGO:0486618.8IL13, ELANE
4positive regulation of B cell proliferationGO:0308908.8IL13, IL5, IL4
5inflammatory responseGO:0069548.7IL13, IL5, CCL11
6immune responseGO:0069558.4IL13, IL5, IL4, CCL11

Molecular functions related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7IL13, IL5, IL4

Products for genes affiliated with Conjunctivitis

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  • Antibodies
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Sources for Conjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet