MCID: CNJ013
MIFTS: 55

Conjunctivitis malady

Summaries for Conjunctivitis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 Conjunctivitis is a conjunctival disease described as a inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids, which is most commonly due to an allergic reaction or an infection (usually viral, but sometimes bacterial. fungal infections are rare and occur mainly in people who use corticosteroid eye drops for a long time or have eye injuries involving vegetable matter. newborns are particularly susceptible to eye infections, which they acquire from organisms in the mother's birth canal (neonatal conjunctivitis.

MalaCards: Conjunctivitis, also known as conjunctivitis, unspecified, is related to allergic conjunctivitis and giant papillary conjunctivitis. An important gene associated with Conjunctivitis is PLG (plasminogen), and among its related pathways are Generic Transcription Pathway and Transcriptional Regulation of White Adipocyte Differentiation. The drugs prednisolone and prednisolone acetate and the compounds vegf and n acetylcysteine have been mentioned in the context of this disorder.

CDC:3 Basics about the causes, signs & symptoms, diagnosis, prevention, treatment...

Wikipedia:64 Conjunctivitis (also called pink eye or madras eye in India) is inflammation of the conjunctiva (the... more...

Aliases & Classifications for Conjunctivitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

conjunctivitis 8 10 45 61
conjunctivitis, unspecified 8
unspecified conjunctivitis 8


External Ids:

Disease Ontology8 DOID:6195
NCIt40 C34504
MeSH35 D003231
ICD9CM27 372.30

Related Diseases for Conjunctivitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Conjunctivitis family:

acute conjunctivitis bacterial conjunctivitis
chronic conjunctivitis conjunctivitis with pseudomembrane

Diseases related to Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 283)
idRelated DiseaseScoreTop Affiliating Genes
1allergic conjunctivitis31.7IL4, RNASE3, IGHE, CCL11
2giant papillary conjunctivitis31.2CCL11, RNASE3
3allergic rhinitis30.5IL4, RNASE3, IGHE, CCL11
4vernal keratoconjunctivitis30.4CCL11, IGHE, RNASE3, IL4
5arthritis30.3IL4, PLG
6uveitis30.2IL4, CCL11
7asthma30.2IGHE, RNASE3, IL4
8allergic asthma30.1CCL11, IGHE, RNASE3, IL4
9atopic dermatitis29.9IL4, RNASE3, IGHE, CCL11
10sinusitis29.9CCL11, IGHE, RNASE3
11bullous pemphigoid29.7RNASE3, IGHE, CCL11
12urticaria29.7IGHE, RNASE3
13acute conjunctivitis11.0
14bacterial conjunctivitis10.9
15inclusion conjunctivitis10.8
16acute hemorrhagic conjunctivitis10.8
17vernal conjunctivitis10.8
18trachoma10.6
19conjunctivitis ligneous10.6
20blepharitis10.4
21ophthalmia neonatorum10.3
22chronic follicular conjunctivitis10.3
23pseudomembranous conjunctivitis10.2
24cellulitis10.1
25rosacea conjunctivitis10.1
26lymphogranuloma venereum10.1
27orbital cellulitis10.1
28acute contagious conjunctivitis10.1
29reactive arthritis10.1
30measles10.1
31n syndrome10.1
32adenocarcinoma10.1
33iritis10.0
34urethritis10.0
35cholera10.0
36ophthalmomyiasis10.0
37coccidioidomycosis10.0
38serous conjunctivitis except viral10.0
39stevens-johnson syndrome10.0
40gingival recession10.0
41cicatricial pemphigoid10.0
42simple chronic conjunctivitis10.0
43parasitic conjunctivitis10.0
44squamous cell carcinoma10.0
45anterior uveitis10.0
46breast cancer10.0CCL11, MRE11A, MED14, MED1, MAPKAPK2, EPHB4
47rheumatoid arthritis10.0CCL11, MAPKAPK2, RNASE3, IL4, PLG
48food allergy10.0CCL11, IGHE, RNASE3, IL4
49pulmonary eosinophilia10.0IL4, RNASE3, IGHE, CCL11
50eosinophilia10.0CCL11, IGHE, RNASE3, IL4

Graphical network of the top 20 diseases related to Conjunctivitis:



Diseases related to conjunctivitis

Clinical Features for Conjunctivitis

Drugs & Therapeutics for Conjunctivitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Conjunctivitis

Drug clinical trials:

Search ClinicalTrials for Conjunctivitis

Search NIH Clinical Center for Conjunctivitis

Search CenterWatch for Conjunctivitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Conjunctivitis

Anatomical Context for Conjunctivitis

Animal Models for Conjunctivitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Conjunctivitis

Sources:
51PubMed
See all sources

Articles related to Conjunctivitis:

(show top 50)    (show all 1442)
idTitleAuthorsYear
1
Influence of aeroallergens on the incidence of conjunctivitis in Zagreb and Zagreb County. (23837216)
2013
2
Emerging therapies in allergic conjunctivitis and dry eye syndrome. (23822862)
2013
3
Relationship between air pollution and outpatient visits for nonspecific conjunctivitis. (22205603)
2012
4
The clinical significance of perilimbal conjunctival pigmentation in vernal conjunctivitis. (22237184)
2012
5
Loteprednol etabonate suspension 0.2% administered QID compared with olopatadine solution 0.1% administered BID in the treatment of seasonal allergic conjunctivitis: a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. (22627057)
2012
6
Effect of rasanjana madhu ashchyotana in netra abhishyanda (mucopurulent conjunctivitis). (22529652)
2011
7
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. (20523096)
2010
8
Efficacy and safety of azithromycin 1.5% eye drops for purulent bacterial conjunctivitis in pediatric patients. (19935122)
2010
9
Molecular and immunocytochemical identification of coxsackievirus A-24 variant from the acute haemorrhagic conjunctivitis outbreak in Taiwan in 2007. (19218990)
2010
10
Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial. (18631332)
2009
11
Plasminogen deficiency as a rare cause of conjunctivitis and lymphadenopathy. (19011568)
2009
12
Epinastine 0.05% ophthalmic solution in contact lens-wearing subjects with a history of allergic conjunctivitis. (19125045)
2009
13
Tear fluid concentration of mmp-8 is elevated in non-allergic eosinophilic conjunctivitis and correlates with conjunctival inflammatory cell infiltration. (19184080)
2009
14
Conjunctivitis. (18834020)
2008
15
Moxifloxacin versus polymyxin B/trimethoprim sulfate in pediatric bacterial conjunctivitis. (19043943)
2008
16
Clinical cure of bacterial conjunctivitis with azithromycin 1%: vehicle-controlled, double-masked clinical trial. (18374301)
2008
17
Clinical value of conjunctival allergen challenge in diagnosing allergic conjunctivitis related to latex. (17481715)
2007
18
Comment on "Clinical features of bacterial conjunctivitis in children". (17656612)
2007
19
Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis. (17174273)
2007
20
T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase. (17532058)
2007
21
The Relationship between chlamydia trachomatis and chlamydia pneumoniae as the cause of neonatal conjunctivitis (ophthalmia neonatorum). (16088243)
2005
22
Detailed criteria for the assessment of clinical symptoms in a new murine model of severe allergic conjunctivitis. (14703703)
2003
23
Efficacy and safety of topical azelastine compared with topical mitomycin C in patients with allergic conjunctivitis. (12658084)
2003
24
Demographic study of paediatric allergic conjunctivitis within a multiethnic patient population. (12928306)
2003
25
Twice-daily and once-daily nedocromil sodium 2% ophthalmic solution for the treatment of seasonal allergic conjunctivitis. (12008862)
2002
26
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. (11838991)
2002
27
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
28
Efficacy and safety of ketorolac tromethamine 0.5% and levocabastine 0.05%: a multicenter comparison in patients with seasonal allergic conjunctivitis. (11010060)
2000
29
Azelastine eye-drops in seasonal allergic conjunctivitis or rhinoconjunctivitis. A double-blind, randomized, placebo-controlled study. (9788686)
1998
30
Chronic follicular conjunctivitis associated with Chlamydia psittaci or Chlamydia pneumoniae. (9636859)
1998
31
The current and future therapy of allergic conjunctivitis. (10387470)
1998
32
Allergic conjunctivitis as a risk factor for regression and haze after photorefractive keratectomy. (9641431)
1998
33
Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis. (9188930)
1997
34
Flow cytometry tear analysis in patients with chronic allergic conjunctivitis. (9152806)
1997
35
Management of allergic conjunctivitis. (9082254)
1997
36
Allergic conjunctivitis. (9166629)
1997
37
Chronic allergic conjunctivitis. (22827184)
1993
38
Levocabastine eye drops versus sodium cromoglycate in seasonal allergic conjunctivitis. (1680537)
1991
39
Evolutionary study on the Coxsackievirus A 24 variant causing acute hemorrhagic conjunctivitis by oligonucleotide mapping analysis of RNA genome. (2171464)
1990
40
Conjunctival provocation tests and naturally occurring allergic conjunctivitis in clinical trials. (3053496)
1988
41
Fucithalmic in acute conjunctivitis. Open, randomized comparison of fusidic acid, chloramphenicol and framycetin eye drops. (3300139)
1987
42
Giant papillary conjunctivitis from an exposed prolene suture. (3756614)
1986
43
Mucous membrane grafting for severe palpebral vernal conjunctivitis. (6508608)
1984
44
Acute conjunctivitis caused by an atypical chlamydial strain: Chlamydia IOL 207. (6722073)
1984
45
Synergistic antiviral effects of interferon plus antibody against acute hemorrhagic conjunctivitis viruses, herpes virus and adenovirus. (6189220)
1981-1982
46
An epidemic of acute hemorrhagic conjunctivitis in Sendai area, 1973-1974. (189457)
1976
47
CHRONIC CONJUNCTIVITIS. (14047012)
1963
48
Staining of the inclusion bodies of trachoma and inclusion conjunctivitis. (13572759)
1958
49
Ophthalmia neonatorum and gonococcal conjunctivitis. (18105465)
1949
50
INCLUSION CONJUNCTIVITIS. (20321548)
1939

Genetic Variations for Conjunctivitis

Expression for genes affiliated with Conjunctivitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Conjunctivitis

Search GEO for disease gene expression data for Conjunctivitis.

Pathways for genes affiliated with Conjunctivitis

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Conjunctivitis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1vegf4511.3CCL11, IGHE, EPHB4, RNASE3, IL4, PLG
2n acetylcysteine4511.3CCL11, IGHE, RNASE3, IL4, PLG
3montelukast45 50 29 1114.2IL4, RNASE3, IGHE, CCL11
4budesonide45 50 1113.2IL4, RNASE3, IGHE, CCL11
5fluticasone propionate45 50 60 1114.2CCL11, IGHE, RNASE3, IL4
6methacholine45 1112.2IL4, RNASE3, IGHE, CCL11
7allergens4511.2IL4, RNASE3, IGHE, CCL11
8unicap4511.2CCL11, IGHE, RNASE3
9anti-histamine4511.1RNASE3, IGHE, CCL11
10sodium cromoglycate4511.1CCL11, IGHE, RNASE3
11cetirizine45 29 11 2414.1CCL11, IGHE, RNASE3
12nedocromil sodium4511.1IGHE, RNASE3, IL4
13rantes4511.1IL4, RNASE3, MAPKAPK2, CCL11
14pranlukast45 29 1113.1CCL11, RNASE3, IL4
15praziquantel45 1112.1IL4, RNASE3, IGHE
16ketotifen45 1112.1CCL11, IGHE, RNASE3
17salmeterol45 50 29 1114.1CCL11, RNASE3, IL4
18azelastine45 1112.1IL4, RNASE3, IGHE
19salbutamol45 50 29 11 2415.1CCL11, IGHE, RNASE3
20pgd24511.1RNASE3, IGHE, CCL11
21tarc4511.0CCL11, IGHE, IL4
22levocetirizine4511.0IL4, CCL11
23omalizumab45 1112.0IL4, IGHE
24tele-methylhistamine4510.9IGHE, RNASE3
25steroid4510.9CCL11, MED1, RNASE3, FSHB, PLG
26beclomethasone dipropionate4510.9IGHE, RNASE3
27ovomucoid4510.9IL4, IGHE
28histamine45 29 2412.9IL4, RNASE3, IGHE, CCL11
29toluene diisocyanate4510.9IGHE, RNASE3
30lte44510.9CCL11, RNASE3
31formoterol45 29 1112.9IL4, RNASE3
32desloratadine45 1111.8IL4, IGHE
33fenoterol45 29 1112.8IL4, IGHE
34loratadine45 11 2412.8IGHE, RNASE3
35penicillin4510.7IGHE, MED1
36prednisolone45 29 1112.6RNASE3, IGHE, CCL11
37actinomycin d4510.5CCL11, IGHE, IL4, FSHB

GO Terms for genes affiliated with Conjunctivitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mediator complexGO:01659211.0MED27, MED7, MED14, MED26, MED17, MED1
2nucleoplasmGO:00565411.0MRE11A, MED7, MED14, MED26, MED17, MED1
3transcription factor complexGO:00566710.8MED27, MED23, MED17, MED7

Biological processes related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1gene expressionGO:01046711.5MED7, MED14, MED26, MED17, MED1, MED23
2transcription initiation from RNA polymerase II promoterGO:00636711.3MED27, MED7, MED14, MED26, MED17, MED1
3regulation of transcription from RNA polymerase II promoterGO:00635711.2MED7, MED14, MED26, MED17, MED23, MED27
4stem cell maintenanceGO:01982710.9MED7, MED14, MED17, MED27
5positive regulation of transcription from RNA polymerase II promoterGO:04594410.9MED17, MED1, IL4, FSHB, MED14
6intracellular steroid hormone receptor signaling pathwayGO:03051810.8MED1, MED17, MED14
7androgen receptor signaling pathwayGO:03052110.7MED14, MED17, MED1
8embryonic heart tube developmentGO:03505010.6NKX2-6, MED1
9ERK1 and ERK2 cascadeGO:07037110.4MED1, CCL11

Molecular functions related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.6OGN, MRE11A, MED7, MED26, MED1, MED23
2transcription coactivator activityGO:00371311.2MED7, MED14, MED26, MED17, MED1, MED23
3RNA polymerase II transcription cofactor activityGO:00110411.1MED1, MED17, MED26, MED14, MED7
4vitamin D receptor bindingGO:04280910.8MED14, MED17, MED1
5thyroid hormone receptor bindingGO:04696610.7MED1, MED17, MED14
6ligand-dependent nuclear receptor transcription coactivator activityGO:03037410.6MED14, MED17, MED1
7transcription cofactor activityGO:00371210.4MED1, MED17, MED14

Products for genes affiliated with Conjunctivitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Conjunctivitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet