MCID: CNJ013
MIFTS: 61

Conjunctivitis malady

Summaries for Conjunctivitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 Conjunctivitis is a conjunctival disease described as a inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids, which is most commonly due to an allergic reaction or an infection (usually viral, but sometimes bacterial. fungal infections are rare and occur mainly in people who use corticosteroid eye drops for a long time or have eye injuries involving vegetable matter. newborns are particularly susceptible to eye infections, which they acquire from organisms in the mother's birth canal (neonatal conjunctivitis.

MalaCards: Conjunctivitis, also known as conjunctivitis, unspecified, is related to allergic conjunctivitis and giant papillary conjunctivitis. An important gene associated with Conjunctivitis is PLG (plasminogen), and among its related pathways are Generic Transcription Pathway and Transcriptional Regulation of White Adipocyte Differentiation. The drugs cromolyn sodium and oxymetazoline and the compounds vegf and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells.

Wikipedia:63 Conjunctivitis (also called pink eye or madras eye in India) is inflammation of the conjunctiva (the... more...

Aliases & Classifications for Conjunctivitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

conjunctivitis 8 10 44 60
conjunctivitis, unspecified 8
unspecified conjunctivitis 8


External Ids:

Disease Ontology8 DOID:6195
NCIt39 C34504
MeSH34 D003231
ICD9CM27 372.30

Related Diseases for Conjunctivitis

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17GeneCards, 18GeneDecks
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Diseases in the Conjunctivitis family:

Acute Conjunctivitis Bacterial Conjunctivitis
Chronic Conjunctivitis

Diseases related to Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 354)
idRelated DiseaseScoreTop Affiliating Genes
1allergic conjunctivitis31.6RNASE3, CCL11, IGHE, IL4
2giant papillary conjunctivitis31.1CCL11, RNASE3
3keratoconjunctivitis30.5RNASE3, CCL11
4rhinitis30.5IL4, CCL11, IGHE, RNASE3
5pneumonia30.4CCL11
6allergic rhinitis30.4IL4, RNASE3, IGHE, CCL11
7arthritis30.3IL4, PLG
8uveitis30.2IL4, CCL11
9asthma30.0IGHE, RNASE3, IL4
10rheumatoid arthritis30.0IL4, CCL11, PLG, MAPKAPK2, RNASE3
11allergic asthma30.0RNASE3, IGHE, CCL11, IL4
12eosinophilia30.0CCL11, IGHE, IL4, RNASE3
13influenza30.0CCL11
14breast cancer29.8MRE11A, MED14, PLG, CCL11, MED1, MAPKAPK2
15atopic dermatitis29.8IGHE, RNASE3, CCL11, IL4
16otitis media29.8CCL11, IGHE, RNASE3
17bullous pemphigoid29.6RNASE3, IGHE, CCL11
18urticaria29.6RNASE3, IGHE
19nephrotic syndrome29.6CCL11
20sarcoidosis29.6CCL11
21acute conjunctivitis11.0
22bacterial conjunctivitis10.8
23papillary conjunctivitis10.8
24inclusion conjunctivitis10.8
25acute hemorrhagic conjunctivitis10.8
26vernal conjunctivitis10.7
27chronic conjunctivitis10.7
28trachoma10.5
29conjunctivitis ligneous10.4
30keratitis10.4
31blepharitis10.3
32ophthalmia neonatorum10.3
33chronic follicular conjunctivitis10.2
34pseudomembranous conjunctivitis10.2
35dermatitis10.2
36conjunctivitis with pseudomembrane10.2
37corneal ulcer10.1
38urethritis10.1
39cellulitis10.1
40rosacea conjunctivitis10.1
41lymphogranuloma venereum10.1
42eye disease10.1
43leukemia10.1
44prostatitis10.1
45orbital cellulitis10.0
46acute contagious conjunctivitis10.0
47angelucci's syndrome10.0
48reactive arthritis10.0
49measles10.0
50adenocarcinoma10.0

Graphical network of the top 20 diseases related to Conjunctivitis:



Diseases related to conjunctivitis

Clinical Features for Conjunctivitis

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Drugs & Therapeutics for Conjunctivitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Conjunctivitis

Drug clinical trials:

Search ClinicalTrials for Conjunctivitis

Search NIH Clinical Center for Conjunctivitis

Search CenterWatch for Conjunctivitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Conjunctivitis

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Anatomical Context for Conjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Conjunctivitis:

32
Eye, Testes, T cells, Bone, Prostate, Lung, Colon, Bone marrow, Endothelial, Kidney, Skin, Breast, Lymph node, Liver, Myeloid, B cells, Monocytes, Ovary, Thyroid, Small intestine, Heart, Spinal cord, Brain, Pituitary

Animal Models for Conjunctivitis or affiliated genes

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Publications for Conjunctivitis

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50PubMed
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Articles related to Conjunctivitis:

(show top 50)    (show all 1632)
idTitleAuthorsYear
1
Immunomodulators for conjunctivitis. (23974685)
2013
2
Azithromycin reduces inflammation in a rat model of acute conjunctivitis. (23378729)
2013
3
Nutritional support process for a patient with short bowel syndrome in conjunction with panperitonitis: a case report. (23908982)
2013
4
Chronic conjunctivitis related to phthiriasis palpebrarum. (22707338)
2012
5
Loteprednol etabonate suspension 0.2% administered QID compared with olopatadine solution 0.1% administered BID in the treatment of seasonal allergic conjunctivitis: a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. (22627057)
2012
6
Assessment of a computerised decision support system for allergic rhino-conjunctivitis counselling in German pharmacy. (22108789)
2012
7
Virucidal mechanism of action of NVC-422, a novel antimicrobial drug for the treatment of adenoviral conjunctivitis. (22024427)
2011
8
Local treatment of methicillin-resistant Staphylococcus aureus conjunctivitis with short-term high-concentrated minocycline ointment. (21789624)
2011
9
Botulinum toxin A in conjunction with occupational therapy reduces spasticity and improves upper limb function and goal attainment in children with cerebral palsy. (21418237)
2011
10
A randomised placebo-controlled trial of topical steroid in presumed viral conjunctivitis. (21252084)
2011
11
Membranous conjunctivitis from adverse drug reaction: Stevens-Johnson syndrome. (21352369)
2011
12
Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study. (20383847)
2010
13
Quantification of tear proteins and sPLA2-IIa alteration in patients with allergic conjunctivitis. (21042565)
2010
14
Diagnosis and localisation of insulinoma: the value of modern magnetic resonance imaging in conjunction with calcium stimulation catheterisation. (20207727)
2010
15
Which urine marker test provides more diagnostic value in conjunction with standard cytology- ImmunoCyt/uCyt+ or Cytokeratin 20 expression. (19558643)
2009
16
Is it possible to detect the presence of adenovirus in conjunctiva before the onset of conjunctivitis? (19178389)
2009
17
Treatment of allergic conjunctivitis with olopatadine hydrochloride eye drops. (19668750)
2008
18
3-day treatment with azithromycin 1.5% eye drops versus 7-day treatment with tobramycin 0.3% for purulent bacterial conjunctivitis: multicentre, randomised and controlled trial in adults and children. (17050578)
2007
19
Comment on "Clinical features of bacterial conjunctivitis in children". (17656612)
2007
20
Clinical features of bacterial conjunctivitis in children. (17119185)
2007
21
Analysis of the interaction between IFN-gamma and IFN-gammaR in the effector phase of experimental murine allergic conjunctivitis. (16987553)
2006
22
A randomized, investigator- masked clinical trial comparing the efficacy and safety of gatifloxacin 0.3% administered BID versus QID for the treatment BID versus QID for the treatment of acute bacterial conjunctivitis of acute bacterial conjunctivitis. (15811211)
2005
23
p21waf1/cip1 is down-regulated in conjunction with up-regulation of c-Fos in the lymphocytes of rheumatoid arthritis patients. (12705898)
2003
24
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. (11838991)
2002
25
A comparison of the efficacy and tolerability of olopatadine hydrochloride 0.1% ophthalmic solution and cromolyn sodium 2% ophthalmic solution in seasonal allergic conjunctivitis. (12462286)
2002
26
An evaluation of sodium bicarbonate chewing gum in reducing dental plaque and gingivitis in conjunction with regular toothbrushing. (11913310)
2001
27
MSH4 acts in conjunction with MLH1 during mammalian meiosis. (10928988)
2000
28
Comparison of the conjunctival allergen challenge model with the environmental model of allergic conjunctivitis. (10337431)
1999
29
Allergic contact conjunctivitis and blepharitis from tobramycin. (7774207)
1995
30
Effect of (Z)-11-[3-(dimethylamino) propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride on experimental allergic conjunctivitis and rhinitis in rats and guinea pigs. (7488300)
1995
31
Selection of patients with the antiphospholipid syndrome by serological measurement of lupus anticoagulant activity in conjunction with anticardiolipin antibodies. (1600690)
1992
32
Double-blind trial of pentigetide ophthalmic solution, 0.5%, compared with cromolyn sodium, 4%, ophthalmic solution for allergic conjunctivitis. (1903616)
1991
33
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. (1846131)
1991
34
Detection by brush cytology of mast cells and eosinophils in allergic and vernal conjunctivitis. (1782781)
1991
35
Acute hemorrhagic conjunctivitis--Mexico. (2540410)
1989
36
Acute hemorrhagic conjunctivitis caused by coxsackie A24 variant--Puerto Rico. (2828909)
1988
37
Cromolyn sodium in seasonal allergic conjunctivitis. (3932499)
1985
38
Diagnosis of allergic conjunctivitis. (6466185)
1984
39
Enterovirus 70 acute hemorrhagic conjunctivitis--sporadic cases. (6381837)
1984
40
Trimethoprim-polymyxin B ophthalmic solution in the treatment of presumptive bacterial conjunctivitis--a multicentre trial of its efficacy versus neomycin-polymyxin B-gramicidin and chloramphenicol ophthalmic solutions. (6188739)
1983
41
Acute bacterial conjunctivitis--southeastern Georgia, 1981. (6813674)
1982
42
Giant papillary conjunctivitis. (7239822)
1981
43
An outbreak of acute conjunctivitis caused by coxsackievirus A24 in Kuala-Lumpur, Malaysia, 1978. (6250226)
1980
44
The use of provocation tests for the diagnosis of allergic conjunctivitis caused by Japanese cedar. (6787745)
1980
45
Immunity to vaginal reinfection in female guinea pigs infected sexually with Chlamydia of guinea pig inclusion conjunctivitis. (640729)
1978
46
Effect of interferon, elevated temperature, and cell type on replication of acute hemorrhagic conjunctivitis viruses. (200562)
1977
47
Ultrastructural study of trachoma and inclusion conjunctivitis. (1028127)
1976
48
Observations on experimental trachoma and inclusion conjunctivitis. (13372656)
1956
49
Conjunctivitis in adenoidal-pharyngeal-conjunctival virus infection; pharyngoconjunctival fever, a newly described entity. (14397906)
1955
50
INCLUSION CONJUNCTIVITIS. (20321548)
1939

Genetic Variations for Conjunctivitis

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Expression for genes affiliated with Conjunctivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conjunctivitis

Search GEO for disease gene expression data for Conjunctivitis.

Pathways for genes affiliated with Conjunctivitis

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53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Conjunctivitis

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1vegf4411.3CCL11, IGHE, EPHB4, RNASE3, IL4, PLG
2n acetylcysteine4411.3CCL11, IGHE, RNASE3, IL4, PLG
3montelukast44 49 28 1114.2IL4, RNASE3, IGHE, CCL11
4budesonide44 49 1113.2IL4, RNASE3, IGHE, CCL11
5fluticasone propionate44 49 59 1114.2CCL11, IGHE, RNASE3, IL4
6methacholine44 1112.2IL4, RNASE3, IGHE, CCL11
7allergens4411.2IL4, RNASE3, IGHE, CCL11
8unicap4411.2CCL11, IGHE, RNASE3
9anti-histamine4411.1RNASE3, IGHE, CCL11
10sodium cromoglycate4411.1CCL11, IGHE, RNASE3
11cetirizine44 28 11 2414.1CCL11, IGHE, RNASE3
12nedocromil sodium4411.1IGHE, RNASE3, IL4
13rantes4411.1IL4, RNASE3, MAPKAPK2, CCL11
14pranlukast44 28 1113.1CCL11, RNASE3, IL4
15praziquantel44 1112.1IL4, RNASE3, IGHE
16ketotifen44 1112.1CCL11, IGHE, RNASE3
17salmeterol44 49 28 1114.1CCL11, RNASE3, IL4
18azelastine44 1112.1IL4, RNASE3, IGHE
19salbutamol44 49 28 11 2415.1CCL11, IGHE, RNASE3
20pgd24411.1RNASE3, IGHE, CCL11
21tarc4411.0CCL11, IGHE, IL4
22levocetirizine4411.0IL4, CCL11
23omalizumab44 1112.0IL4, IGHE
24tele-methylhistamine4410.9IGHE, RNASE3
25steroid4410.9CCL11, MED1, RNASE3, FSHB, PLG
26beclomethasone dipropionate4410.9IGHE, RNASE3
27ovomucoid4410.9IL4, IGHE
28histamine44 28 2412.9IL4, RNASE3, IGHE, CCL11
29toluene diisocyanate4410.9IGHE, RNASE3
30lte44410.9CCL11, RNASE3
31formoterol44 28 1112.9IL4, RNASE3
32desloratadine44 1111.8IL4, IGHE
33fenoterol44 28 1112.8IL4, IGHE
34loratadine44 11 2412.8IGHE, RNASE3
35penicillin4410.7IGHE, MED1
36prednisolone44 28 1112.6RNASE3, IGHE, CCL11
37actinomycin d4410.5CCL11, IGHE, IL4, FSHB

GO Terms for genes affiliated with Conjunctivitis

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16Gene Ontology
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Cellular components related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mediator complexGO:01659211.0MED27, MED7, MED14, MED26, MED17, MED1
2nucleoplasmGO:00565411.0MRE11A, MED7, MED14, MED26, MED17, MED1
3transcription factor complexGO:00566710.8MED27, MED23, MED17, MED7

Biological processes related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1gene expressionGO:01046711.5MED7, MED14, MED26, MED17, MED1, MED23
2transcription initiation from RNA polymerase II promoterGO:00636711.3MED27, MED7, MED14, MED26, MED17, MED1
3regulation of transcription from RNA polymerase II promoterGO:00635711.2MED7, MED14, MED26, MED17, MED23, MED27
4stem cell maintenanceGO:01982710.9MED7, MED14, MED17, MED27
5positive regulation of transcription from RNA polymerase II promoterGO:04594410.9MED17, MED1, IL4, FSHB, MED14
6intracellular steroid hormone receptor signaling pathwayGO:03051810.8MED1, MED17, MED14
7androgen receptor signaling pathwayGO:03052110.7MED14, MED17, MED1
8embryonic heart tube developmentGO:03505010.6NKX2-6, MED1
9ERK1 and ERK2 cascadeGO:07037110.4MED1, CCL11

Molecular functions related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.6OGN, MRE11A, MED7, MED26, MED1, MED23
2transcription coactivator activityGO:00371311.2MED7, MED14, MED26, MED17, MED1, MED23
3RNA polymerase II transcription cofactor activityGO:00110411.1MED1, MED17, MED26, MED14, MED7
4vitamin D receptor bindingGO:04280910.8MED14, MED17, MED1
5thyroid hormone receptor bindingGO:04696610.7MED1, MED17, MED14
6ligand-dependent nuclear receptor transcription coactivator activityGO:03037410.6MED14, MED17, MED1
7transcription cofactor activityGO:00371210.4MED1, MED17, MED14

Products for genes affiliated with Conjunctivitis

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Sources for Conjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet