MCID: CNJ013
MIFTS: 61

Conjunctivitis malady

Summaries for Conjunctivitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 Conjunctivitis is a conjunctival disease described as a inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids, which is most commonly due to an allergic reaction or an infection (usually viral, but sometimes bacterial. fungal infections are rare and occur mainly in people who use corticosteroid eye drops for a long time or have eye injuries involving vegetable matter. newborns are particularly susceptible to eye infections, which they acquire from organisms in the mother's birth canal (neonatal conjunctivitis.

MalaCards: Conjunctivitis, also known as conjunctivitis, unspecified, is related to allergic conjunctivitis and giant papillary conjunctivitis. An important gene associated with Conjunctivitis is PLG (plasminogen), and among its related pathways are Generic Transcription Pathway and Transcriptional Regulation of White Adipocyte Differentiation. The drugs prednisolone and prednisolone acetate and the compounds vegf and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells.

Wikipedia:63 Conjunctivitis (also called pink eye or madras eye in India) is inflammation of the conjunctiva (the... more...

Aliases & Classifications for Conjunctivitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

conjunctivitis 8 10 44 60
conjunctivitis, unspecified 8
unspecified conjunctivitis 8


External Ids:

Disease Ontology8 DOID:6195
NCIt39 C34504
MeSH34 D003231
ICD9CM27 372.30

Related Diseases for Conjunctivitis

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17GeneCards, 18GeneDecks
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Diseases in the Conjunctivitis family:

Acute Conjunctivitis Bacterial Conjunctivitis
Chronic Conjunctivitis

Diseases related to Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 354)
idRelated DiseaseScoreTop Affiliating Genes
1allergic conjunctivitis31.6RNASE3, CCL11, IGHE, IL4
2giant papillary conjunctivitis31.1CCL11, RNASE3
3keratoconjunctivitis30.5RNASE3, CCL11
4rhinitis30.5IL4, CCL11, IGHE, RNASE3
5pneumonia30.4CCL11
6allergic rhinitis30.4IL4, RNASE3, IGHE, CCL11
7arthritis30.3IL4, PLG
8uveitis30.2IL4, CCL11
9asthma30.0IGHE, RNASE3, IL4
10rheumatoid arthritis30.0IL4, CCL11, PLG, MAPKAPK2, RNASE3
11allergic asthma30.0RNASE3, IGHE, CCL11, IL4
12eosinophilia30.0CCL11, IGHE, IL4, RNASE3
13influenza30.0CCL11
14breast cancer29.8MRE11A, MED14, PLG, CCL11, MED1, MAPKAPK2
15atopic dermatitis29.8IGHE, RNASE3, CCL11, IL4
16otitis media29.8CCL11, IGHE, RNASE3
17bullous pemphigoid29.6RNASE3, IGHE, CCL11
18urticaria29.6RNASE3, IGHE
19nephrotic syndrome29.6CCL11
20sarcoidosis29.6CCL11
21acute conjunctivitis11.0
22bacterial conjunctivitis10.8
23papillary conjunctivitis10.8
24inclusion conjunctivitis10.8
25acute hemorrhagic conjunctivitis10.8
26vernal conjunctivitis10.7
27chronic conjunctivitis10.7
28trachoma10.5
29conjunctivitis ligneous10.4
30keratitis10.4
31blepharitis10.3
32ophthalmia neonatorum10.3
33chronic follicular conjunctivitis10.2
34pseudomembranous conjunctivitis10.2
35dermatitis10.2
36conjunctivitis with pseudomembrane10.2
37corneal ulcer10.1
38urethritis10.1
39cellulitis10.1
40rosacea conjunctivitis10.1
41lymphogranuloma venereum10.1
42eye disease10.1
43leukemia10.1
44prostatitis10.1
45orbital cellulitis10.0
46acute contagious conjunctivitis10.0
47angelucci's syndrome10.0
48reactive arthritis10.0
49measles10.0
50adenocarcinoma10.0

Graphical network of the top 20 diseases related to Conjunctivitis:



Diseases related to conjunctivitis

Clinical Features for Conjunctivitis

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Drugs & Therapeutics for Conjunctivitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Conjunctivitis

Drug clinical trials:

Search ClinicalTrials for Conjunctivitis

Search NIH Clinical Center for Conjunctivitis

Search CenterWatch for Conjunctivitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Conjunctivitis

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Anatomical Context for Conjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Conjunctivitis:

32
Eye, Testes, T cells, Bone, Prostate, Bone marrow, Colon, Endothelial, Lung, Breast, Kidney, Skin, Liver, Lymph node, Small intestine, Pituitary, B cells, Monocytes, Myeloid, Spinal cord, Thyroid, Ovary, Brain, Heart

Animal Models for Conjunctivitis or affiliated genes

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Publications for Conjunctivitis

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50PubMed
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Articles related to Conjunctivitis:

(show top 50)    (show all 1632)
idTitleAuthorsYear
1
Coxa vara in conjunction with metaphyseal dysostosis. (22747872)
2012
2
A review of non-pharmacological and pharmacological management of seasonal and perennial allergic conjunctivitis. (21925924)
2012
3
Microbiological etiology and susceptibility of bacterial conjunctivitis isolates from clinical trials with ophthalmic, twice-daily besifloxacin. (22644963)
2012
4
What I learned from DTB: acute infective conjunctivitis? (22611126)
2012
5
Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis. (21171952)
2011
6
Relationship between myopia and allergen-specific serum IgE levels in patients with allergic conjunctivitis. (19788663)
2009
7
Ocular rhinosporidiosis presenting as chronic follicular conjunctivitis in a contact lens wearer. (19667358)
2009
8
Clinical evaluation of total IgE in tears of patients with allergic conjunctivitis disease using a novel application of the immunochromatography method. (19779297)
2009
9
Epinastine 0.05% ophthalmic solution in contact lens-wearing subjects with a history of allergic conjunctivitis. (19125045)
2009
10
Transcriptional analyses before and after suppression of immediate hypersensitivity reactions by CCR3 blockade in eyes with experimental allergic conjunctivitis. (18658092)
2008
11
B7-H3 regulates the development of experimental allergic conjunctivitis in mice. (17825429)
2007
12
Bacterial conjunctivitis. (19450350)
2007
13
Efficacy of levocabastine hydrochloride ophthalmic suspension in the conjunctival allergen challenge test in Japanese subjects with seasonal allergic conjunctivitis. (17075252)
2006
14
Tear film lipid layer alterations in allergic conjunctivitis. (16633026)
2006
15
Role of interferon-gamma in a mouse model of allergic conjunctivitis. (16123425)
2005
16
Allergens in Japanese patients with allergic conjunctivitis in autumn. (15389269)
2005
17
Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2. (15507617)
2004
18
Detection of Mycoplasma conjunctivae in sheep affected with conjunctivitis and infectious keratoconjunctivitis. (16032322)
2003
19
Can diet in conjunction with stress reduction affect the rate of increase in prostate specific antigen after biochemical recurrence of prostate cancer? (11696736)
2001
20
Vascular permeability in allergic conjunctivitis in mice lacking histamine H1 receptors. (11108826)
2000
21
Phage infection of the obligate intracellular bacterium, Chlamydia psittaci strain guinea pig inclusion conjunctivitis. (10955956)
2000
22
Mitomycin-C and vernal conjunctivitis. (11097575)
2000
23
A genotypic male with anorchia in conjunction with isolated idiopathic hypogonadotropic hypogonadism. (10573004)
1999
24
An outbreak of acute conjunctivitis due to coxsackie A24 virus in Delhi. (9282517)
1997
25
Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF. (9032255)
1997
26
Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis. (8919742)
1996
27
High bone density in hyperandrogenic women: effect of gonadotropin-releasing hormone agonist alone or in conjunction with estrogen-progestin replacement. (8636283)
1996
28
Allergic conjunctivitis and dry eye. (8976728)
1996
29
Serotyping of Chlamydia trachomatis from inclusion conjunctivitis by polymerase chain reaction and restriction fragment length polymorphism analysis. (8876399)
1996
30
Mast cell distribution and neutral protease expression in acute and chronic allergic conjunctivitis. (7728624)
1995
31
Comparison of Naphcon-A and its components (naphazoline and pheniramine) in a provocative model of allergic conjunctivitis. (8055694)
1994
32
Sodium cromoglycate eye drops: regular versus "as needed" use in the treatment of seasonal allergic conjunctivitis. (8027497)
1994
33
Unusual causes of giant papillary conjunctivitis. (8458237)
1993
34
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. (1499122)
1992
35
Acute hemorrhagic conjunctivitis due to enterovirus 70 in American Samoa: serum-neutralizing antibodies and sex-specific protection. (1337662)
1992
36
Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. (1825106)
1991
37
Evolutionary study on the Coxsackievirus A 24 variant causing acute hemorrhagic conjunctivitis by oligonucleotide mapping analysis of RNA genome. (2171464)
1990
38
Giant papillary conjunctivitis associated with rigid gas permeable contact lenses. (3208429)
1988
39
Giant papillary conjunctivitis. (3053490)
1988
40
Acute bacterial conjunctivitis and maltose negative meningococci. (6439758)
1984
41
Neisseria gonorrhoeae conjunctivitis. An outbreak during an epidemic of acute hemorrhagic conjunctivitis. (6308287)
1983
42
Marginal corneal ulcers with acute beta streptococcal conjunctivitis and chronic dacryocystitis. (375740)
1979
43
Giant papillary conjunctivitis and ptosis in a contact lens wearer. (458521)
1979
44
Neurologic complications with elevated antibody titer after acute hemorrhagic conjunctivitis. (171960)
1975
45
Acute hemorrhagic conjunctivitis. (4612807)
1974
46
Bacterial flora in acute conjunctivitis. (5618268)
1967
47
Gentamicin in the treatment of bacterial conjunctivitis. (5338672)
1967
48
Inclusion conjunctivitis in the guinea pig. (6028622)
1967
49
Ophthalmomyiasis externa; larval conjunctivitis in socket. (13057428)
1953
50
The significance of conjunctival eosinophilia in the diagnosis of allergic conjunctivitis. (14896900)
1951

Genetic Variations for Conjunctivitis

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Expression for genes affiliated with Conjunctivitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conjunctivitis

Search GEO for disease gene expression data for Conjunctivitis.

Pathways for genes affiliated with Conjunctivitis

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53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Conjunctivitis

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1vegf4411.3CCL11, RNASE3, EPHB4, PLG, IGHE, IL4
2n acetylcysteine4411.3CCL11, IGHE, RNASE3, IL4, PLG
3montelukast44 49 28 1114.2CCL11, IL4, RNASE3, IGHE
4budesonide44 49 1113.2CCL11, RNASE3, IL4, IGHE
5fluticasone propionate44 49 59 1114.2IL4, RNASE3, CCL11, IGHE
6methacholine44 1112.2IL4, IGHE, CCL11, RNASE3
7allergens4411.2IGHE, CCL11, IL4, RNASE3
8unicap4411.2CCL11, RNASE3, IGHE
9anti-histamine4411.1RNASE3, IGHE, CCL11
10sodium cromoglycate4411.1RNASE3, IGHE, CCL11
11nedocromil sodium4411.1IL4, IGHE, RNASE3
12cetirizine44 28 11 2414.1CCL11, IGHE, RNASE3
13rantes4411.1MAPKAPK2, RNASE3, IL4, CCL11
14pranlukast44 28 1113.1CCL11, IL4, RNASE3
15praziquantel44 1112.1IGHE, RNASE3, IL4
16ketotifen44 1112.1RNASE3, CCL11, IGHE
17salmeterol44 49 28 1114.1CCL11, IL4, RNASE3
18azelastine44 1112.1IGHE, RNASE3, IL4
19salbutamol44 49 28 11 2415.1RNASE3, IGHE, CCL11
20pgd24411.1IGHE, RNASE3, CCL11
21tarc4411.0CCL11, IGHE, IL4
22levocetirizine4411.0CCL11, IL4
23omalizumab44 1112.0IL4, IGHE
24beclomethasone dipropionate4410.9IGHE, RNASE3
25steroid4410.9CCL11, PLG, MED1, RNASE3, FSHB
26tele-methylhistamine4410.9IGHE, RNASE3
27ovomucoid4410.9IL4, IGHE
28histamine44 28 2412.9RNASE3, IGHE, IL4, CCL11
29lte44410.9CCL11, RNASE3
30toluene diisocyanate4410.9IGHE, RNASE3
31formoterol44 28 1112.9IL4, RNASE3
32desloratadine44 1111.8IL4, IGHE
33fenoterol44 28 1112.8IL4, IGHE
34loratadine44 11 2412.8IGHE, RNASE3
35penicillin4410.7MED1, IGHE
36prednisolone44 28 1112.6RNASE3, IGHE, CCL11
37actinomycin d4410.5IGHE, IL4, FSHB, CCL11

GO Terms for genes affiliated with Conjunctivitis

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16Gene Ontology
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Cellular components related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mediator complexGO:01659211.0MED7, MED14, MED26, MED17, MED1, MED23
2nucleoplasmGO:00565411.0MAPKAPK2, MRE11A, MED26, MED7, MED27, MED23
3transcription factor complexGO:00566710.8MED27, MED7, MED17, MED23

Biological processes related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1gene expressionGO:01046711.5MED14, MED27, MAPKAPK2, SRPR, MED7, MED1
2transcription initiation from RNA polymerase II promoterGO:00636711.3MED26, MED7, MED14, MED17, MED1, MED23
3regulation of transcription from RNA polymerase II promoterGO:00635711.2MED7, MED27, MED14, MED26, MED17, MED23
4stem cell maintenanceGO:01982710.9MED7, MED14, MED17, MED27
5positive regulation of transcription from RNA polymerase II promoterGO:04594410.9MED14, MED17, MED1, FSHB, IL4
6intracellular steroid hormone receptor signaling pathwayGO:03051810.8MED1, MED17, MED14
7androgen receptor signaling pathwayGO:03052110.7MED14, MED17, MED1
8embryonic heart tube developmentGO:03505010.6NKX2-6, MED1
9ERK1 and ERK2 cascadeGO:07037110.4MED1, CCL11

Molecular functions related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.6PLG, FSHB, IL4, CCL11, OGN, MRE11A
2transcription coactivator activityGO:00371311.2MED17, MED26, MED14, MED7, MED1, MED23
3RNA polymerase II transcription cofactor activityGO:00110411.1MED1, MED17, MED26, MED14, MED7
4vitamin D receptor bindingGO:04280910.8MED14, MED17, MED1
5thyroid hormone receptor bindingGO:04696610.7MED1, MED17, MED14
6ligand-dependent nuclear receptor transcription coactivator activityGO:03037410.6MED1, MED14, MED17
7transcription cofactor activityGO:00371210.4MED1, MED17, MED14

Products for genes affiliated with Conjunctivitis

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Sources for Conjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet