Aliases & Classifications for Conjunctivitis

About this section
Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 3CDC, 60UMLS, 38NCIt, 55SNOMED-CT, 27ICD9CM, 33MeSH, 25ICD10
See all sources

Conjunctivitis, Aliases & Descriptions:

Name: Conjunctivitis 9 11 43 3 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:6195
NCIt38 C34504
ICD9CM27 372.30
MeSH33 D003231
ICD1025 H10

Summaries for Conjunctivitis

About this section


Disease Ontology:9 Conjunctivitis is a conjunctival disease described as a inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids, which is most commonly due to an allergic reaction or an infection (usually viral, but sometimes bacterial. fungal infections are rare and occur mainly in people who use corticosteroid eye drops for a long time or have eye injuries involving vegetable matter. newborns are particularly susceptible to eye infections, which they acquire from organisms in the mother's birth canal (neonatal conjunctivitis.

MalaCards based summary: Conjunctivitis is related to giant papillary conjunctivitis and allergic conjunctivitis. An important gene associated with Conjunctivitis is PLG (plasminogen), and among its related pathways are amb2 Integrin signaling and Matrix Metalloproteinases. The drugs cromolyn sodium and oxymetazoline and the compounds unicap and lte4 have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

CDC:3 Conjunctivitis is often called "pink eye" or "red eye" because it can cause the white of the eye to take on a pink or red color. Signs and symptoms of pink eye can vary but typically include redness or swelling of the white of the eye.

Wikipedia:63 Conjunctivitis, also known as pink eyeor Madras eye is inflammation of the conjunctiva (the outermost... more...

Related Diseases for Conjunctivitis

About this section

Diseases in the Conjunctivitis family:

Acute Conjunctivitis Bacterial Conjunctivitis
Chronic Conjunctivitis

Diseases related to Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 439)
idRelated DiseaseScoreTop Affiliating Genes
1giant papillary conjunctivitis31.4RNASE3, CCL11, IL5
2allergic conjunctivitis31.1RNASE3, CCL11, IL4, IL5, IL13
3conjunctivitis ligneous30.9PLG, ELANE
4uveitis30.5IL4, CCL11
5asthma30.4CCL11, IL13
6otitis media30.3RNASE3, CCL11
7keratoconjunctivitis30.3RNASE3, CCL11, IL5, IL13
8pneumonia30.1IL13, IL5, CCL11, ELANE
9sinusitis30.1RNASE3, CCL11, IL5
10dermatitis30.0CCL11, IL4, IL5, IL13
11allergic rhinitis30.0RNASE3, IL4, IL5, IL13
12arthritis29.9FCER2, IL4, IL13, PLG
13urticaria29.9RNASE3, FCER2
14kawasaki disease29.8FCER2, ELANE
15vernal keratoconjunctivitis29.8RNASE3, CCL11, IL4, IL5, IL13
16leukemia29.7FCER2, RNASE3, CCL11, IL4, PLG
17viral infectious disease29.6CCL11, IL4, IL13
18rhinitis29.5FCER2, RNASE3, CCL11, IL4, IL5, IL13
19atherosclerosis29.5PLG, CCL11, ELANE
20nephrotic syndrome29.4CCL11, IL13
21atopic dermatitis29.3FCER2, RNASE3, CCL11, IL4, IL13
22pulmonary disease, chronic obstructive29.3RNASE3, ELANE, CCL11, IL13
23inflammatory bowel disease29.2ELANE, CCL11, IL4, IL13
24eosinophilia29.0IL13, IL5, IL4, CCL11, RNASE3, FCER2
25bullous pemphigoid28.9FCER2, RNASE3, CCL11, IL5, IL13
26rheumatoid arthritis28.7FCER2, RNASE3, ELANE, CCL11, IL4, IL13
27bacterial conjunctivitis10.9
28papillary conjunctivitis10.8
29inclusion conjunctivitis10.8
30acute hemorrhagic conjunctivitis10.8
31acute conjunctivitis10.7
32vernal conjunctivitis10.7
33chronic conjunctivitis10.7
34trachoma10.6
35folliculitis10.5CCL11
36blindness10.5
37aspergillosis10.4ELANE
38paragonimiasis10.4IL5
39malaria10.4FCER2
40keratitis10.4
41strongyloidiasis10.4IL5
42blepharitis10.4
43ophthalmia neonatorum10.3
44chronic follicular conjunctivitis10.3
45common cold10.3RNASE3, CCL11
46esophagitis, eosinophilic, 110.3IL5, CCL11
47hyper-ige recurrent infection syndrome10.3RNASE3, IL4
48kimura disease10.3RNASE3, IL5
49pseudomembranous conjunctivitis10.2
50conjunctivitis with pseudomembrane10.2

Graphical network of the top 20 diseases related to Conjunctivitis:



Diseases related to conjunctivitis

Symptoms for Conjunctivitis

About this section

Drugs & Therapeutics for Conjunctivitis

About this section

Genetic Tests for Conjunctivitis

About this section

Anatomical Context for Conjunctivitis

About this section

MalaCards organs/tissues related to Conjunctivitis:

31
Eye, Testes, T cells, Bone, Skin, Prostate, Bone marrow, Colon, Lung, Endothelial, Kidney, Breast, Lymph node, Liver, Brain, Spinal cord, Heart, Small intestine, Thyroid, Ovary, Myeloid, Monocytes, B cells, Pituitary, Neutrophil

Animal Models for Conjunctivitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Conjunctivitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9CCL11, IL4, IL5, IL13, PLG
2MP:00053817.4FCER2, IL4, IL5, IL13, PLG
3MP:00053767.2PLG, IL13, IL5, IL4, ELANE, FCER2
4MP:00053976.9PLG, FCER2, ELANE, CCL11, IL4, IL5
5MP:00053876.8FCER2, ELANE, CCL11, IL4, IL5, IL13

Publications for Conjunctivitis

About this section

Articles related to Conjunctivitis:

(show top 50)    (show all 1692)
idTitleAuthorsYear
1
Culture medium from TNF-I+-stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms. (25652765)
2015
2
Chronic Conjunctivitis due to Nocardia nova Complex Formation on a Silicone Stent: A Case Report and Review of the Literature. (24892274)
2014
3
Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer. (24420556)
2014
4
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. (23092529)
2013
5
Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. (23212114)
2013
6
Understanding the origin of seasonal epidemics of mycoplasmal conjunctivitis. (22524311)
2012
7
Lichen planus and cicatricial conjunctivitis: disease course and response to therapy of 11 patients. (20477930)
2011
8
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
9
Detection of Chlamydophila caviae and Streptococcus equi subsp. zooepidemicus in horses with signs of rhinitis and conjunctivitis. (19913370)
2010
10
Increasing case numbers of adenovirus conjunctivitis in Germany, 2010. (21087592)
2010
11
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. (20523096)
2010
12
Occupational conjunctivitis as the sole manifestation of airborne contact allergy to trimethylolpropane triacrylate contained in a UV-cured paint. (19076890)
2008
13
Association between beta2 adrenergic receptor polymorphisms and rheumatoid arthritis in conjunction with human leukocyte antigen (HLA)-DRB1 shared epitope. (18267980)
2008
14
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. (17680326)
2007
15
Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. (17701212)
2007
16
Management of acute conjunctivitis in school-aged children. (17410958)
2007
17
Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis. (17560570)
2007
18
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
19
Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase. (15557278)
2005
20
Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2. (15507617)
2004
21
Coccidiosis control with toltrazuril in conjunction with anticoccidial medicated or nonmedicated feed. (12887207)
2003
22
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
23
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. (12941273)
2003
24
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
25
Vascular permeability in allergic conjunctivitis in mice lacking histamine H1 receptors. (11108826)
2000
26
Mitomycin-C and vernal conjunctivitis. (11097580)
2000
27
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
28
The role of IL-12 in the induction of late-phase cellular infiltration in a murine model of allergic conjunctivitis. (10669851)
2000
29
Demineralization inhibition at glass-ionomer cement and amalgam restoration margins in conjunction with additional fluoride regimens. (10483457)
1999
30
Dry eye in allergic conjunctivitis: role of inflammatory infiltrate. (12783641)
1999
31
Conjunction dysfunction: CBP/p300 in human disease. (9613201)
1998
32
Dose-dependent protection by azelastine eye drops against pollen-induced allergic conjunctivitis. A double-blind, placebo-controlled study. (9608880)
1998
33
Allergic conjunctivitis from eyedrops. (9226074)
1997
34
Index of suspicion. Case 2. Diagnosis: gonorrhea conjunctivitis. (9114719)
1997
35
Detection of serum antibodies to Chlamydia pneumoniae in patients with endogenous uveitis and acute conjunctivitis. (9356816)
1997
36
Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis. (8919742)
1996
37
Levocabastine eye drops in vernal conjunctivitis. (8963170)
1995
38
Double-blind trial of pentigetide ophthalmic solution, 0.5%, compared with cromolyn sodium, 4%, ophthalmic solution for allergic conjunctivitis. (1903616)
1991
39
Expressive therapy in conjunction with psychotherapy in the treatment of persons with multiple personality disorder. (2252072)
1990
40
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
41
Acute hemorrhagic conjunctivitis--Mexico. (2540410)
1989
42
An epidemic of acute hemorrhagic conjunctivitis in the city of Sao Paulo. (2834590)
1987
43
Tear film flow and stability in acute and chronic conjunctivitis. (3618153)
1987
44
A double-blind crossover study comparing sodium cromoglycate eye drops with placebo in the treatment of chronic conjunctivitis. (6431741)
1984
45
Recurrent conjunctivitis in neonatal herpes infection. (6889160)
1983
46
Synergistic antiviral effects of interferon plus antibody against acute hemorrhagic conjunctivitis viruses, herpes virus and adenovirus. (6189220)
1981-1982
47
An epidemic of acute conjunctivitis caused by enterovirus-70 in Singapore in 1980. (6283679)
1981
48
An outbreak of acute conjunctivitis caused by coxsackievirus A24 in Kuala-Lumpur, Malaysia, 1978. (6250226)
1980
49
Intrarectal infection of guinea pigs with the agent of guinea pig inclusion conjunctivitis. (1013148)
1976
50
Acute conjunctivitis and moraxella. (5338673)
1967

Variations for Conjunctivitis

About this section

Expression for genes affiliated with Conjunctivitis

About this section
Search GEO for disease gene expression data for Conjunctivitis.

Pathways for genes affiliated with Conjunctivitis

About this section

Pathways related to Conjunctivitis according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6PLG, ELANE
2
Show member pathways
9.6PLG, ELANE
3
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.5IL5, IL4
49.5IL4, IL5
5
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.0FCER2, CCL11, IL4
68.9IL5, IL4, FCER2
7
Show member pathways
8.9PLG, IL13, IL4
8
Show member pathways
Type III interferon signaling36
8.7IL4, IL5, IL13
9
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.7IL13, IL5, IL4
10
Show member pathways
8.7IL4, IL5, IL13
118.7IL13, IL5, IL4
128.7IL4, IL5, IL13
138.7IL13, IL5, IL4
148.7IL4, IL5, IL13
158.7IL13, IL5, IL4
168.5FCER2, CCL11, IL4, IL5
17
Show member pathways
8.3CCL11, IL4, IL5, IL13
18
Show member pathways
8.3IL13, IL5, IL4, CCL11
19
Show member pathways
8.3CCL11, IL4, IL5, IL13
20
Show member pathways
8.3CCL11, IL4, IL5, IL13
21
Show member pathways
7.9IL13, IL5, IL4, CCL11, RNASE3
22
Show member pathways
7.7IL13, IL5, IL4, CCL11, FCER2

Compounds for genes affiliated with Conjunctivitis

About this section

Compounds related to Conjunctivitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1unicap439.5RNASE3, CCL11, IL5
2lte4439.5IL5, RNASE3, CCL11
3sodium cromoglycate439.5RNASE3, CCL11, IL5
4cetirizine43 28 24 1212.4CCL11, IL5, RNASE3
5ketotifen43 1210.3RNASE3, CCL11, IL5
6azelastine43 1210.2IL5, RNASE3, IL4
7pranlukast43 28 1211.1IL4, IL5, CCL11, RNASE3
8formoterol43 28 1211.1IL4, IL13, RNASE3
9omalizumab43 1210.0IL4, IL13, IL5
10n-formylmethionyl-leucylphenylalanine439.0IL5, CCL11, ELANE, RNASE3
11glatiramer acetate43 129.9IL4, IL5, IL13
12nedocromil sodium438.9IL5, RNASE3, IL4, FCER2
13amphotericin b438.8IL13, IL5, IL4
14ltd4438.8RNASE3, IL5, IL13
15ltc4438.7IL13, IL5, CCL11, RNASE3
16pgd2438.7IL13, IL5, CCL11, RNASE3
17praziquantel43 129.7IL13, IL4, RNASE3, IL5
18il-12438.7IL13, IL4, IL5
19tarc438.7CCL11, IL4, IL5, IL13
20ovomucoid438.6IL13, ELANE, IL5, IL4
21prednisolone43 28 1210.6IL13, RNASE3, IL5, CCL11
22gm-csf43 289.5ELANE, IL13, IL5, IL4
23herbimycin a43 599.4IL5, IL4, CCL11, FCER2
24hyaluronic acid43 249.3CCL11, RNASE3, IL13, ELANE
25salmeterol43 49 28 1211.3CCL11, IL4, IL13, RNASE3, IL5
26montelukast43 49 28 1211.3RNASE3, IL5, IL13, CCL11, IL4
27budesonide43 49 1210.3CCL11, IL4, IL5, RNASE3, IL13
28methacholine43 49 1210.3CCL11, IL4, IL5, IL13, RNASE3
29aspirin43 49 28 2411.3CCL11, RNASE3, ELANE, IL4, IL13
30rantes438.2CCL11, IL4, IL5, IL13, RNASE3
31rolipram43 59 2810.2CCL11, IL5, IL13, ELANE, IL4
32salbutamol43 49 28 24 1212.2RNASE3, CCL11, IL13, IL5, FCER2
33ionomycin438.1IL13, IL5, IL4, CCL11, FCER2
34sb 20358043 599.0IL4, IL5, IL13, CCL11, FCER2
35hydrocortisone43 2 59 1210.9FCER2, ELANE, IL4, IL5, IL13
36vegf437.9CCL11, RNASE3, IL4, IL5, PLG, IL13
37heparin43 28 24 1210.9PLG, IL13, IL5, CCL11, ELANE, RNASE3
38thyroxine43 248.9IL13, ELANE, IL5, IL4
39fluticasone propionate43 49 59 1210.8IL13, CCL11, ELANE, IL4, RNASE3, IL5
40cyclosporin a43 28 599.8RNASE3, ELANE, CCL11, IL5, IL13, IL4
41thymidine43 248.7PLG, FCER2, CCL11, IL4, IL5, IL13
42allergens437.7IL4, IL5, RNASE3, FCER2, CCL11, IL13
43histamine43 28 249.7RNASE3, CCL11, IL4, FCER2, IL5, IL13
44leukotriene b443 59 249.6RNASE3, ELANE, IL5, CCL11, FCER2, IL13
45fmlp437.6IL13, IL5, CCL11, ELANE, RNASE3, FCER2
46dexamethasone43 49 28 1210.6RNASE3, IL4, IL5, IL13, CCL11, FCER2
47retinoic acid43 248.5CCL11, ELANE, RNASE3, IL5, IL13, FCER2
48cysteine437.4IL13, ELANE, IL5, FCER2, IL4, PLG
49tyrosine437.2IL4, PLG, IL13, RNASE3, FCER2, CCL11
50pge2437.2ELANE, CCL11, IL4, RNASE3, FCER2, IL13

GO Terms for genes affiliated with Conjunctivitis

About this section

Cellular components related to Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6IL13, IL4, FCER2
2extracellular spaceGO:00056157.7CCL11, IL4, IL5, IL13, PLG
3extracellular regionGO:00055767.4PLG, IL13, IL5, CCL11, ELANE, RNASE3

Biological processes related to Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular calcium ion homeostasisGO:00068749.6CCL11, ELANE
2regulation of proton transportGO:00101559.2IL4, IL13
3positive regulation of smooth muscle cell proliferationGO:00486618.8IL13, ELANE
4positive regulation of B cell proliferationGO:00308908.8IL13, IL5, IL4
5inflammatory responseGO:00069548.7IL13, IL5, CCL11
6immune responseGO:00069558.4IL13, IL5, IL4, CCL11

Molecular functions related to Conjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.7IL13, IL5, IL4

Products for genes affiliated with Conjunctivitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Conjunctivitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet