MCID: CNJ013
MIFTS: 63

Conjunctivitis malady

Eye diseases category
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Summaries for Conjunctivitis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 Conjunctivitis is a conjunctival disease described as a inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids, which is most commonly due to an allergic reaction or an infection (usually viral, but sometimes bacterial. fungal infections are rare and occur mainly in people who use corticosteroid eye drops for a long time or have eye injuries involving vegetable matter. newborns are particularly susceptible to eye infections, which they acquire from organisms in the mother's birth canal (neonatal conjunctivitis.

MalaCards: Conjunctivitis, also known as conjunctivitis, unspecified, is related to allergic conjunctivitis and giant papillary conjunctivitis. An important gene associated with Conjunctivitis is PLG (plasminogen), and among its related pathways are amb2 Integrin signaling and Matrix Metalloproteinases. The drugs cromolyn sodium and oxymetazoline and the compounds unicap and lte4 have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

Wikipedia:65 Conjunctivitis (also called pink eye in North America or madras eye in India) is inflammation of the... more...

Aliases & Classifications for Conjunctivitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

conjunctivitis 8 10 45 62
conjunctivitis, unspecified 8
unspecified conjunctivitis 8


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Disease Ontology8 DOID:6195
ICD9CM27 372.30
NCIt40 C34504
MeSH35 D003231

Related Diseases for Conjunctivitis

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17GeneCards, 18GeneDecks
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Diseases in the Conjunctivitis family:

Acute Conjunctivitis Bacterial Conjunctivitis
Chronic Conjunctivitis

Diseases related to Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 403)
idRelated DiseaseScoreTop Affiliating Genes
1allergic conjunctivitis31.5RNASE3, CCL11, IL4, IL5, IL13
2giant papillary conjunctivitis31.2IL5, CCL11, RNASE3
3conjunctivitis ligneous30.7ELANE, PLG
4keratoconjunctivitis30.5IL13, IL5, CCL11, RNASE3
5pneumonia30.4ELANE, CCL11, IL13, IL5
6rhinitis30.3IL5, IL13, IL4, CCL11, RNASE3, FCER2
7uveitis30.3IL4, CCL11
8vernal keratoconjunctivitis30.3IL4, RNASE3, IL13, CCL11, IL5
9dermatitis30.2CCL11, IL4, IL5, IL13
10arthritis30.2FCER2, IL4, IL13, PLG
11allergic rhinitis30.2FCER2, IL13, RNASE3, CCL11, IL4, IL5
12asthma30.2CCL11, IL13
13leukemia30.1IL4, PLG, RNASE3, FCER2, CCL11
14otitis media30.0CCL11, RNASE3
15sinusitis29.9RNASE3, IL5, CCL11
16eosinophilia29.8IL5, IL13, IL4, CCL11, RNASE3, FCER2
17atopic dermatitis29.7CCL11, RNASE3, IL4, IL13, FCER2
18rheumatoid arthritis29.7PLG, IL13, ELANE, IL4, FCER2, RNASE3
19urticaria29.7FCER2, RNASE3
20atherosclerosis29.6ELANE, CCL11, PLG
21sarcoidosis29.6IL13, FCER2, CCL11
22nephrotic syndrome29.6CCL11, IL13
23inflammatory bowel disease29.6IL13, IL4, CCL11, ELANE
24bullous pemphigoid29.5FCER2, RNASE3, CCL11, IL5, IL13
25bacterial conjunctivitis10.9
26papillary conjunctivitis10.8
27inclusion conjunctivitis10.8
28acute hemorrhagic conjunctivitis10.8
29vernal conjunctivitis10.7
30acute conjunctivitis10.7
31chronic conjunctivitis10.6
32trachoma10.6
33blindness10.5
34keratitis10.4
35blepharitis10.4
36ophthalmia neonatorum10.3
37chronic follicular conjunctivitis10.3
38conjunctivitis with pseudomembrane10.2
39pseudomembranous conjunctivitis10.2
40corneal ulcer10.2
41urethritis10.1
42lymphogranuloma venereum10.1
43cellulitis10.1
44prostatitis10.1
45folliculitis10.1CCL11
46aspergillosis10.1ELANE
47paragonimiasis10.1IL5
48malaria10.1FCER2
49strongyloidiasis10.1IL5
50reactive arthritis10.1

Graphical network of the top 20 diseases related to Conjunctivitis:



Diseases related to conjunctivitis

Symptoms for Conjunctivitis

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Drugs & Therapeutics for Conjunctivitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Conjunctivitis

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Anatomical Context for Conjunctivitis

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33MalaCards
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MalaCards organs/tissues related to Conjunctivitis:

33
Eye, Testes, T cells, Bone, Prostate, Lung, Colon, Bone marrow, Endothelial, Kidney, Skin, Breast, Lymph node, Liver, Myeloid, B cells, Monocytes, Ovary, Thyroid, Small intestine, Heart, Spinal cord, Brain, Pituitary

Animal Models for Conjunctivitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Conjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9CCL11, IL4, IL5, IL13, PLG
2MP:00053817.4FCER2, IL4, IL5, IL13, PLG
3MP:00053767.2PLG, IL13, IL5, IL4, ELANE, FCER2
4MP:00053976.9PLG, FCER2, ELANE, CCL11, IL4, IL5
5MP:00053876.8FCER2, ELANE, CCL11, IL4, IL5, IL13

Publications for Conjunctivitis

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Sources:
52PubMed
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Articles related to Conjunctivitis:

(show top 50)    (show all 1618)
idTitleAuthorsYear
1
Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer. (24420556)
2014
2
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. (23092529)
2013
3
Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. (23212114)
2013
4
Understanding the origin of seasonal epidemics of mycoplasmal conjunctivitis. (22524311)
2012
5
Lichen planus and cicatricial conjunctivitis: disease course and response to therapy of 11 patients. (20477930)
2011
6
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
7
Detection of Chlamydophila caviae and Streptococcus equi subsp. zooepidemicus in horses with signs of rhinitis and conjunctivitis. (19913370)
2010
8
Increasing case numbers of adenovirus conjunctivitis in Germany, 2010. (21087592)
2010
9
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. (20523096)
2010
10
Occupational conjunctivitis as the sole manifestation of airborne contact allergy to trimethylolpropane triacrylate contained in a UV-cured paint. (19076890)
2008
11
Association between beta2 adrenergic receptor polymorphisms and rheumatoid arthritis in conjunction with human leukocyte antigen (HLA)-DRB1 shared epitope. (18267980)
2008
12
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital. (18093859)
2008
13
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. (17680326)
2007
14
Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. (17701212)
2007
15
Management of acute conjunctivitis in school-aged children. (17410958)
2007
16
Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis. (17560570)
2007
17
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
18
Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase. (15557278)
2005
19
Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2. (15507617)
2004
20
Coccidiosis control with toltrazuril in conjunction with anticoccidial medicated or nonmedicated feed. (12887207)
2003
21
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
22
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. (12941273)
2003
23
Nedocromil sodium ophthalmic solution 2% twice daily in patients with allergic conjunctivitis. (12069370)
2002
24
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
25
Vascular permeability in allergic conjunctivitis in mice lacking histamine H1 receptors. (11108826)
2000
26
Mitomycin-C and vernal conjunctivitis. (11097580)
2000
27
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
28
The role of IL-12 in the induction of late-phase cellular infiltration in a murine model of allergic conjunctivitis. (10669851)
2000
29
Demineralization inhibition at glass-ionomer cement and amalgam restoration margins in conjunction with additional fluoride regimens. (10483457)
1999
30
Dry eye in allergic conjunctivitis: role of inflammatory infiltrate. (12783641)
1999
31
Conjunction dysfunction: CBP/p300 in human disease. (9613201)
1998
32
Dose-dependent protection by azelastine eye drops against pollen-induced allergic conjunctivitis. A double-blind, placebo-controlled study. (9608880)
1998
33
Allergic conjunctivitis from eyedrops. (9226074)
1997
34
Index of suspicion. Case 2. Diagnosis: gonorrhea conjunctivitis. (9114719)
1997
35
Detection of serum antibodies to Chlamydia pneumoniae in patients with endogenous uveitis and acute conjunctivitis. (9356816)
1997
36
Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis. (8919742)
1996
37
Levocabastine eye drops in vernal conjunctivitis. (8963170)
1995
38
Double-blind trial of pentigetide ophthalmic solution, 0.5%, compared with cromolyn sodium, 4%, ophthalmic solution for allergic conjunctivitis. (1903616)
1991
39
Expressive therapy in conjunction with psychotherapy in the treatment of persons with multiple personality disorder. (2252072)
1990
40
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
41
Acute hemorrhagic conjunctivitis--Mexico. (2540410)
1989
42
An epidemic of acute hemorrhagic conjunctivitis in the city of Sao Paulo. (2834590)
1987
43
Tear film flow and stability in acute and chronic conjunctivitis. (3618153)
1987
44
A double-blind crossover study comparing sodium cromoglycate eye drops with placebo in the treatment of chronic conjunctivitis. (6431741)
1984
45
Recurrent conjunctivitis in neonatal herpes infection. (6889160)
1983
46
Synergistic antiviral effects of interferon plus antibody against acute hemorrhagic conjunctivitis viruses, herpes virus and adenovirus. (6189220)
1981-1982
47
An epidemic of acute conjunctivitis caused by enterovirus-70 in Singapore in 1980. (6283679)
1981
48
An outbreak of acute conjunctivitis caused by coxsackievirus A24 in Kuala-Lumpur, Malaysia, 1978. (6250226)
1980
49
Intrarectal infection of guinea pigs with the agent of guinea pig inclusion conjunctivitis. (1013148)
1976
50
Acute conjunctivitis and moraxella. (5338673)
1967

Variations for Conjunctivitis

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Expression for genes affiliated with Conjunctivitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conjunctivitis

Search GEO for disease gene expression data for Conjunctivitis.

Pathways for genes affiliated with Conjunctivitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 12EMD Millipore, 60Thomson Reuters, 30KEGG, 54R&D Systems
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Pathways related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6PLG, ELANE
2
Show member pathways
9.6PLG, ELANE
3
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.5IL5, IL4
49.5IL4, IL5
59.1CCL11, IL4, IL5
6
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.0FCER2, CCL11, IL4
78.9IL5, IL4, FCER2
8
Show member pathways
8.9PLG, IL13, IL4
9
Show member pathways
Type III interferon signaling38
8.7IL4, IL5, IL13
10
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.7IL13, IL5, IL4
11
Show member pathways
8.7IL4, IL5, IL13
128.7IL13, IL5, IL4
138.7IL4, IL5, IL13
148.7IL13, IL5, IL4
158.7IL4, IL5, IL13
168.7IL13, IL5, IL4
178.5FCER2, CCL11, IL4, IL5
18
Show member pathways
8.3CCL11, IL4, IL5, IL13
19
Show member pathways
8.3IL13, IL5, IL4, CCL11
20
Show member pathways
8.3CCL11, IL4, IL5, IL13
21
Show member pathways
8.3CCL11, IL4, IL5, IL13
22
Show member pathways
7.9IL13, IL5, IL4, CCL11, RNASE3
23
Show member pathways
7.7IL13, IL5, IL4, CCL11, FCER2

Compounds for genes affiliated with Conjunctivitis

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 3BitterDB
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Compounds related to Conjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1unicap459.5RNASE3, CCL11, IL5
2lte4459.5IL5, RNASE3, CCL11
3sodium cromoglycate459.5RNASE3, CCL11, IL5
4cetirizine45 29 24 1112.4CCL11, IL5, RNASE3
5ketotifen45 1110.3RNASE3, CCL11, IL5
6azelastine45 1110.2IL5, RNASE3, IL4
7pranlukast45 29 1111.1IL4, IL5, CCL11, RNASE3
8formoterol45 29 1111.1IL4, IL13, RNASE3
9omalizumab45 1110.0IL4, IL13, IL5
10n-formylmethionyl-leucylphenylalanine459.0IL5, CCL11, ELANE, RNASE3
11glatiramer acetate45 119.9IL4, IL5, IL13
12nedocromil sodium458.9IL5, RNASE3, IL4, FCER2
13amphotericin b458.8IL13, IL5, IL4
14ltd4458.8RNASE3, IL5, IL13
15ltc4458.7IL13, IL5, CCL11, RNASE3
16pgd2458.7IL13, IL5, CCL11, RNASE3
17praziquantel45 119.7IL13, IL4, RNASE3, IL5
18il-12458.7IL13, IL4, IL5
19tarc458.7CCL11, IL4, IL5, IL13
20ovomucoid458.6IL13, ELANE, IL5, IL4
21prednisolone45 29 1110.6IL13, RNASE3, IL5, CCL11
22gm-csf45 299.5ELANE, IL13, IL5, IL4
23herbimycin a45 619.4IL5, IL4, CCL11, FCER2
24hyaluronic acid45 249.3CCL11, RNASE3, IL13, ELANE
25salmeterol45 51 29 1111.3CCL11, IL4, IL13, RNASE3, IL5
26montelukast45 51 29 1111.3RNASE3, IL5, IL13, CCL11, IL4
27budesonide45 51 1110.3CCL11, IL4, IL5, RNASE3, IL13
28methacholine45 51 1110.3CCL11, IL4, IL5, IL13, RNASE3
29aspirin45 51 29 2411.3CCL11, RNASE3, ELANE, IL4, IL13
30rantes458.2CCL11, IL4, IL5, IL13, RNASE3
31rolipram45 61 2910.2CCL11, IL5, IL13, ELANE, IL4
32salbutamol45 51 29 24 1112.2RNASE3, CCL11, IL13, IL5, FCER2
33ionomycin458.1IL13, IL5, IL4, CCL11, FCER2
34sb 20358045 619.0IL4, IL5, IL13, CCL11, FCER2
35hydrocortisone45 3 61 1110.9FCER2, ELANE, IL4, IL5, IL13
36vegf457.9CCL11, RNASE3, IL4, IL5, PLG, IL13
37heparin45 29 24 1110.9PLG, IL13, IL5, CCL11, ELANE, RNASE3
38thyroxine45 248.9IL13, ELANE, IL5, IL4
39fluticasone propionate45 51 61 1110.8IL13, CCL11, ELANE, IL4, RNASE3, IL5
40cyclosporin a45 29 619.8RNASE3, ELANE, CCL11, IL5, IL13, IL4
41thymidine45 248.7PLG, FCER2, CCL11, IL4, IL5, IL13
42allergens457.7IL4, IL5, RNASE3, FCER2, CCL11, IL13
43histamine45 29 249.7RNASE3, CCL11, IL4, FCER2, IL5, IL13
44leukotriene b445 61 249.6RNASE3, ELANE, IL5, CCL11, FCER2, IL13
45fmlp457.6IL13, IL5, CCL11, ELANE, RNASE3, FCER2
46dexamethasone45 51 29 1110.6RNASE3, IL4, IL5, IL13, CCL11, FCER2
47retinoic acid45 248.5CCL11, ELANE, RNASE3, IL5, IL13, FCER2
48cysteine457.4IL13, ELANE, IL5, FCER2, IL4, PLG
49tyrosine457.2IL4, PLG, IL13, RNASE3, FCER2, CCL11
50pge2457.2ELANE, CCL11, IL4, RNASE3, FCER2, IL13

GO Terms for genes affiliated with Conjunctivitis

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16Gene Ontology
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Cellular components related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6IL13, IL4, FCER2
2extracellular spaceGO:0056157.7CCL11, IL4, IL5, IL13, PLG
3extracellular regionGO:0055767.4PLG, IL13, IL5, CCL11, ELANE, RNASE3

Biological processes related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular calcium ion homeostasisGO:0068749.6CCL11, ELANE
2regulation of proton transportGO:0101559.2IL4, IL13
3positive regulation of smooth muscle cell proliferationGO:0486618.8IL13, ELANE
4positive regulation of B cell proliferationGO:0308908.8IL13, IL5, IL4
5inflammatory responseGO:0069548.7IL13, IL5, CCL11
6immune responseGO:0069558.4IL13, IL5, IL4, CCL11

Molecular functions related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.7IL13, IL5, IL4

Products for genes affiliated with Conjunctivitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Conjunctivitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet