MCID: CNJ013
MIFTS: 61

Conjunctivitis malady

Eye diseases category

Summaries for Conjunctivitis

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Disease Ontology:10 Conjunctivitis is a conjunctival disease described as a inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids, which is most commonly due to an allergic reaction or an infection (usually viral, but sometimes bacterial. fungal infections are rare and occur mainly in people who use corticosteroid eye drops for a long time or have eye injuries involving vegetable matter. newborns are particularly susceptible to eye infections, which they acquire from organisms in the mother's birth canal (neonatal conjunctivitis.

MalaCards based summary: Conjunctivitis is related to allergic conjunctivitis and giant papillary conjunctivitis. An important gene associated with Conjunctivitis is PLG (plasminogen), and among its related pathways are amb2 Integrin signaling and Matrix Metalloproteinases. The drugs prednisolone and prednisolone acetate and the compounds unicap and lte4 have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

CDC:4 Conjunctivitis is often called "pink eye" or "red eye" because it can cause the white of the eye to take on a pink or red color. Signs and symptoms of pink eye can vary but typically include redness or swelling of the white of the eye.

Wikipedia:65 Conjunctivitis, also known as pink eyeor Madras eye is inflammation of the conjunctiva (the outermost... more...

Aliases & Classifications for Conjunctivitis

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 4CDC, 62UMLS, 40NCIt, 57SNOMED-CT, 29ICD9CM, 35MeSH, 27ICD10
See all sources

Conjunctivitis, Aliases & Descriptions:

Name: Conjunctivitis 10 12 45 4 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology10 DOID:6195
NCIt40 C34504
ICD9CM29 372.30
MeSH35 D003231
ICD1027 H10

Related Diseases for Conjunctivitis

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Diseases in the Conjunctivitis family:

Acute Conjunctivitis Bacterial Conjunctivitis
Chronic Conjunctivitis

Diseases related to Conjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 441)
idRelated DiseaseScoreTop Affiliating Genes
1allergic conjunctivitis31.6RNASE3, CCL11, IL4, IL5, IL13
2giant papillary conjunctivitis31.2IL5, CCL11, RNASE3
3keratoconjunctivitis30.6IL13, IL5, CCL11, RNASE3
4conjunctivitis ligneous30.5ELANE, PLG
5pneumonia30.5ELANE, CCL11, IL13, IL5
6rhinitis30.4IL5, IL13, IL4, CCL11, RNASE3, FCER2
7vernal keratoconjunctivitis30.4IL4, RNASE3, IL13, CCL11, IL5
8dermatitis30.4CCL11, IL4, IL5, IL13
9arthritis30.3FCER2, IL4, IL13, PLG
10allergic rhinitis30.3FCER2, IL13, RNASE3, CCL11, IL4, IL5
11uveitis30.3IL4, CCL11
12asthma30.2CCL11, IL13
13leukemia30.1IL4, PLG, RNASE3, FCER2, CCL11
14otitis media30.0CCL11, RNASE3
15atopic dermatitis29.9CCL11, RNASE3, IL4, IL13, FCER2
16sinusitis29.9RNASE3, IL5, CCL11
17eosinophilia29.9IL5, IL13, IL4, CCL11, RNASE3, FCER2
18rheumatoid arthritis29.9PLG, IL13, ELANE, IL4, FCER2, RNASE3
19urticaria29.7FCER2, RNASE3
20kawasaki disease29.7FCER2, ELANE
21atherosclerosis29.7ELANE, CCL11, PLG
22nephrotic syndrome29.6CCL11, IL13
23pulmonary disease, chronic obstructive29.6ELANE, CCL11, IL13, RNASE3
24inflammatory bowel disease29.6IL13, IL4, CCL11, ELANE
25bullous pemphigoid29.6FCER2, RNASE3, CCL11, IL5, IL13
26bacterial conjunctivitis10.9
27papillary conjunctivitis10.8
28inclusion conjunctivitis10.8
29acute hemorrhagic conjunctivitis10.8
30acute conjunctivitis10.7
31vernal conjunctivitis10.7
32chronic conjunctivitis10.7
33trachoma10.6
34blindness10.5
35keratitis10.4
36blepharitis10.4
37ophthalmia neonatorum10.3
38chronic follicular conjunctivitis10.3
39pseudomembranous conjunctivitis10.2
40conjunctivitis with pseudomembrane10.2
41urethritis10.2
42acute contagious conjunctivitis10.2
43corneal ulcer10.2
44lymphogranuloma venereum10.1
45cellulitis10.1
46prostatitis10.1
47plasminogen deficiency, type i10.1
48reactive arthritis10.1
49measles10.1
50orbital cellulitis10.1

Graphical network of the top 20 diseases related to Conjunctivitis:



Diseases related to conjunctivitis

Symptoms for Conjunctivitis

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Drugs & Therapeutics for Conjunctivitis

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Genetic Tests for Conjunctivitis

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Anatomical Context for Conjunctivitis

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MalaCards organs/tissues related to Conjunctivitis:

33
Eye, Testes, T cells, Bone, Skin, Prostate, Bone marrow, Colon, Lung, Endothelial, Kidney, Breast, Lymph node, Liver, Brain, Spinal cord, Heart, Small intestine, Thyroid, Ovary, Myeloid, Monocytes, B cells, Pituitary, Neutrophil

Animal Models for Conjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Conjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9CCL11, IL4, IL5, IL13, PLG
2MP:00053817.4FCER2, IL4, IL5, IL13, PLG
3MP:00053767.2PLG, IL13, IL5, IL4, ELANE, FCER2
4MP:00053976.9PLG, FCER2, ELANE, CCL11, IL4, IL5
5MP:00053876.8FCER2, ELANE, CCL11, IL4, IL5, IL13

Publications for Conjunctivitis

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Articles related to Conjunctivitis:

(show top 50)    (show all 1692)
idTitleAuthorsYear
1
Culture medium from TNF-I+-stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms. (25652765)
2015
2
Chronic Conjunctivitis due to Nocardia nova Complex Formation on a Silicone Stent: A Case Report and Review of the Literature. (24892274)
2014
3
Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer. (24420556)
2014
4
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. (23092529)
2013
5
Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. (23212114)
2013
6
Understanding the origin of seasonal epidemics of mycoplasmal conjunctivitis. (22524311)
2012
7
Lichen planus and cicatricial conjunctivitis: disease course and response to therapy of 11 patients. (20477930)
2011
8
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
9
Detection of Chlamydophila caviae and Streptococcus equi subsp. zooepidemicus in horses with signs of rhinitis and conjunctivitis. (19913370)
2010
10
Increasing case numbers of adenovirus conjunctivitis in Germany, 2010. (21087592)
2010
11
Bilateral conjunctival MALT lymphoma mimicking chronic conjunctivitis. (20523096)
2010
12
Occupational conjunctivitis as the sole manifestation of airborne contact allergy to trimethylolpropane triacrylate contained in a UV-cured paint. (19076890)
2008
13
Association between beta2 adrenergic receptor polymorphisms and rheumatoid arthritis in conjunction with human leukocyte antigen (HLA)-DRB1 shared epitope. (18267980)
2008
14
Molecular identification of coxsackievirus A24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in Singapore in 2005. (17680326)
2007
15
Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. (17701212)
2007
16
Management of acute conjunctivitis in school-aged children. (17410958)
2007
17
Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis. (17560570)
2007
18
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
19
Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase. (15557278)
2005
20
Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2. (15507617)
2004
21
Coccidiosis control with toltrazuril in conjunction with anticoccidial medicated or nonmedicated feed. (12887207)
2003
22
Tumor necrosis factor-alpha (TNF-alpha) in seasonal allergic conjunctivitis and vernal keratoconjunctivitis. (14552593)
2003
23
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. (12941273)
2003
24
Chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and fatal Wegener granulomatosis. (11730661)
2001
25
Vascular permeability in allergic conjunctivitis in mice lacking histamine H1 receptors. (11108826)
2000
26
Mitomycin-C and vernal conjunctivitis. (11097580)
2000
27
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study (10844086)
2000
28
The role of IL-12 in the induction of late-phase cellular infiltration in a murine model of allergic conjunctivitis. (10669851)
2000
29
Demineralization inhibition at glass-ionomer cement and amalgam restoration margins in conjunction with additional fluoride regimens. (10483457)
1999
30
Dry eye in allergic conjunctivitis: role of inflammatory infiltrate. (12783641)
1999
31
Conjunction dysfunction: CBP/p300 in human disease. (9613201)
1998
32
Dose-dependent protection by azelastine eye drops against pollen-induced allergic conjunctivitis. A double-blind, placebo-controlled study. (9608880)
1998
33
Allergic conjunctivitis from eyedrops. (9226074)
1997
34
Index of suspicion. Case 2. Diagnosis: gonorrhea conjunctivitis. (9114719)
1997
35
Detection of serum antibodies to Chlamydia pneumoniae in patients with endogenous uveitis and acute conjunctivitis. (9356816)
1997
36
Immunity to reinfection and immunization of male guinea pigs against urethral infection with the agent of guinea pig inclusion conjunctivitis. (8919742)
1996
37
Levocabastine eye drops in vernal conjunctivitis. (8963170)
1995
38
Double-blind trial of pentigetide ophthalmic solution, 0.5%, compared with cromolyn sodium, 4%, ophthalmic solution for allergic conjunctivitis. (1903616)
1991
39
Expressive therapy in conjunction with psychotherapy in the treatment of persons with multiple personality disorder. (2252072)
1990
40
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. (2196302)
1990
41
Acute hemorrhagic conjunctivitis--Mexico. (2540410)
1989
42
An epidemic of acute hemorrhagic conjunctivitis in the city of Sao Paulo. (2834590)
1987
43
Tear film flow and stability in acute and chronic conjunctivitis. (3618153)
1987
44
A double-blind crossover study comparing sodium cromoglycate eye drops with placebo in the treatment of chronic conjunctivitis. (6431741)
1984
45
Recurrent conjunctivitis in neonatal herpes infection. (6889160)
1983
46
Synergistic antiviral effects of interferon plus antibody against acute hemorrhagic conjunctivitis viruses, herpes virus and adenovirus. (6189220)
1981-1982
47
An epidemic of acute conjunctivitis caused by enterovirus-70 in Singapore in 1980. (6283679)
1981
48
An outbreak of acute conjunctivitis caused by coxsackievirus A24 in Kuala-Lumpur, Malaysia, 1978. (6250226)
1980
49
Intrarectal infection of guinea pigs with the agent of guinea pig inclusion conjunctivitis. (1013148)
1976
50
Acute conjunctivitis and moraxella. (5338673)
1967

Variations for Conjunctivitis

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Expression for genes affiliated with Conjunctivitis

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Search GEO for disease gene expression data for Conjunctivitis.

Pathways for genes affiliated with Conjunctivitis

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Pathways related to Conjunctivitis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6PLG, ELANE
2
Show member pathways
9.6PLG, ELANE
3
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.5IL5, IL4
49.5IL5, IL4
59.1IL5, IL4, CCL11
6
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.0IL4, CCL11, FCER2
78.9IL4, FCER2, IL5
8
Show member pathways
8.9PLG, IL4, IL13
9
Show member pathways
Type III interferon signaling38
8.7IL5, IL13, IL4
10
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.7IL13, IL5, IL4
11
Show member pathways
8.7IL13, IL5, IL4
128.7IL13, IL5, IL4
138.7IL4, IL5, IL13
148.7IL5, IL13, IL4
158.7IL13, IL4, IL5
168.7IL4, IL5, IL13
178.5IL4, IL5, FCER2, CCL11
18
Show member pathways
8.3IL5, IL13, IL4, CCL11
19
Show member pathways
8.3IL13, IL4, CCL11, IL5
20
Show member pathways
8.3IL5, IL4, IL13, CCL11
21
Show member pathways
8.3IL13, IL5, IL4, CCL11
22
Show member pathways
7.9IL5, IL4, RNASE3, IL13, CCL11
23
Show member pathways
7.7IL5, FCER2, CCL11, IL4, IL13

Compounds for genes affiliated with Conjunctivitis

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Compounds related to Conjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1unicap459.5RNASE3, CCL11, IL5
2lte4459.5IL5, RNASE3, CCL11
3sodium cromoglycate459.5RNASE3, CCL11, IL5
4cetirizine45 30 26 1312.4CCL11, IL5, RNASE3
5ketotifen45 1310.3RNASE3, CCL11, IL5
6azelastine45 1310.2IL5, RNASE3, IL4
7pranlukast45 30 1311.1IL4, IL5, CCL11, RNASE3
8formoterol45 30 1311.1IL4, IL13, RNASE3
9omalizumab45 1310.0IL4, IL13, IL5
10n-formylmethionyl-leucylphenylalanine459.0IL5, CCL11, ELANE, RNASE3
11glatiramer acetate45 139.9IL4, IL5, IL13
12nedocromil sodium458.9IL5, RNASE3, IL4, FCER2
13amphotericin b458.8IL13, IL5, IL4
14ltd4458.8RNASE3, IL5, IL13
15ltc4458.7IL13, IL5, CCL11, RNASE3
16pgd2458.7IL13, IL5, CCL11, RNASE3
17praziquantel45 139.7IL13, IL4, RNASE3, IL5
18il-12458.7IL13, IL4, IL5
19tarc458.7CCL11, IL4, IL5, IL13
20ovomucoid458.6IL13, ELANE, IL5, IL4
21prednisolone45 30 1310.6IL13, RNASE3, IL5, CCL11
22gm-csf45 309.5ELANE, IL13, IL5, IL4
23herbimycin a45 619.4IL5, IL4, CCL11, FCER2
24hyaluronic acid45 269.3CCL11, RNASE3, IL13, ELANE
25salmeterol45 51 30 1311.3CCL11, IL4, IL13, RNASE3, IL5
26montelukast45 51 30 1311.3RNASE3, IL5, IL13, CCL11, IL4
27budesonide45 51 1310.3CCL11, IL4, IL5, RNASE3, IL13
28methacholine45 51 1310.3CCL11, IL4, IL5, IL13, RNASE3
29aspirin45 51 30 2611.3CCL11, RNASE3, ELANE, IL4, IL13
30rantes458.2CCL11, IL4, IL5, IL13, RNASE3
31rolipram45 61 3010.2CCL11, IL5, IL13, ELANE, IL4
32salbutamol45 51 30 26 1312.2RNASE3, CCL11, IL13, IL5, FCER2
33ionomycin458.1IL13, IL5, IL4, CCL11, FCER2
34sb 20358045 619.0IL4, IL5, IL13, CCL11, FCER2
35hydrocortisone45 3 61 1310.9FCER2, ELANE, IL4, IL5, IL13
36vegf457.9CCL11, RNASE3, IL4, IL5, PLG, IL13
37heparin45 30 26 1310.9PLG, IL13, IL5, CCL11, ELANE, RNASE3
38thyroxine45 268.9IL13, ELANE, IL5, IL4
39fluticasone propionate45 51 61 1310.8IL13, CCL11, ELANE, IL4, RNASE3, IL5
40cyclosporin a45 30 619.8RNASE3, ELANE, CCL11, IL5, IL13, IL4
41thymidine45 268.7PLG, FCER2, CCL11, IL4, IL5, IL13
42allergens457.7IL4, IL5, RNASE3, FCER2, CCL11, IL13
43histamine45 30 269.7RNASE3, CCL11, IL4, FCER2, IL5, IL13
44leukotriene b445 61 269.6RNASE3, ELANE, IL5, CCL11, FCER2, IL13
45fmlp457.6IL13, IL5, CCL11, ELANE, RNASE3, FCER2
46dexamethasone45 51 30 1310.6RNASE3, IL4, IL5, IL13, CCL11, FCER2
47retinoic acid45 268.5CCL11, ELANE, RNASE3, IL5, IL13, FCER2
48cysteine457.4IL13, ELANE, IL5, FCER2, IL4, PLG
49tyrosine457.2IL4, PLG, IL13, RNASE3, FCER2, CCL11
50pge2457.2ELANE, CCL11, IL4, RNASE3, FCER2, IL13

GO Terms for genes affiliated with Conjunctivitis

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Cellular components related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6IL13, IL4, FCER2
2extracellular spaceGO:00056157.7CCL11, IL4, IL5, IL13, PLG
3extracellular regionGO:00055767.4PLG, IL13, IL5, CCL11, ELANE, RNASE3

Biological processes related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular calcium ion homeostasisGO:00068749.6CCL11, ELANE
2regulation of proton transportGO:00101559.2IL4, IL13
3positive regulation of smooth muscle cell proliferationGO:00486618.8IL13, ELANE
4positive regulation of B cell proliferationGO:00308908.8IL13, IL5, IL4
5inflammatory responseGO:00069548.7IL13, IL5, CCL11
6immune responseGO:00069558.4IL13, IL5, IL4, CCL11

Molecular functions related to Conjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.7IL13, IL5, IL4

Products for genes affiliated with Conjunctivitis

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Sources for Conjunctivitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet