Conjunctivitis Ligneous malady

Wikipedia: Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich...⁴⁴ more...

MalaCards: Conjunctivitis Ligneous, also known as conjunctivitis, ligneous, is related to conjunctivitis and plasminogen deficiency. An important gene associated with Conjunctivitis Ligneous is PLG (plasminogen), and among its related pathways is Cell adhesion_Cell-matrix glycoconjugates. The drugs natamycin and oxymetazoline and the compounds benzamidine and epsilon aminocaproic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney.

OMIM: 217090

conjunctivitis ligneous 30 conjunctivitis, ligneous 33 32

conjunctivitis 43

Diseases related to conjunctivitis ligneous by text searches and GeneDecks gene sharing:

(show top 50)    (show all 117)

id	Related Disease	Score	Top Affiliating Genes
1	conjunctivitis	35.7	PLG, ELANE
2	plasminogen deficiency	27.2	PLG, ELANE
3	fibrosarcoma	25.6	ELANE, PLG
4	thrombosis	25.5	PLG, ELANE
5	adult respiratory distress syndrome	12.5	ELANE, PLG
6	newborn respiratory distress syndrome	12.5	ELANE, PLG
7	aneurysm disease	12.5	ELANE, PLG
8	alcoholic hepatitis	12.5	PLG, ELANE
9	disseminated intravascular coagulation	12.5	PLG, ELANE
10	aspergillosis	12.4	PLG, ELANE
11	hepatopulmonary syndrome	12.4	PLG, ELANE
12	severe acute respiratory syndrome	12.4	PLG, ELANE
13	factor v leiden thrombophilia	12.4	PLG, ELANE
14	sepsis	12.4	ELANE, PLG
15	vasculitis	12.4	ELANE, PLG
16	duodenitis	12.3	ELANE, PLG
17	acute myocardial infarction	12.3	PLG, ELANE
18	glomerulonephritis	12.3	ELANE, PLG
19	coronary heart disease	12.2	PLG, ELANE
20	vascular disease	12.1	ELANE, PLG
21	peritonitis	12.1	PLG, ELANE
22	ulcerative colitis	12.0	PLG, ELANE
23	herpes simplex	11.8	ELANE, PLG
24	allergic conjunctivitis	9.5
25	giant papillary conjunctivitis	8.2
26	chronic conjunctivitis	8.0
27	vernal conjunctivitis	8.0
28	inclusion conjunctivitis	7.6
29	papillary conjunctivitis	7.6
30	acute hemorrhagic conjunctivitis	7.3
31	bacterial conjunctivitis	7.1
32	pseudomembranous conjunctivitis	7.1
33	acute contagious conjunctivitis	6.8
34	angelucci's syndrome	6.8
35	leukemia	6.8
36	ophthalmia neonatorum	6.8
37	acute conjunctivitis	6.5
38	chronic follicular conjunctivitis	6.5
39	carcinoma	6.5
40	measles	6.5
41	parasitic conjunctivitis	6.5
42	prostatitis	6.5
43	serous conjunctivitis except viral	6.5
44	conjunctivitis with pseudomembrane	6.2
45	gonococcal conjunctivitis	6.2
46	keratoconjunctivitis	6.2
47	prostate cancer	6.2
48	rheumatoid arthritis	6.2
49	rosacea conjunctivitis	6.2
50	simple chronic conjunctivitis	6.2

Clinical features from OMIM: 217090

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cromolyn, cromolyn sodium, natamycin, oxymetazoline, oxymetazoline hydrochloride, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate

MalaCards organs/tissues related to conjunctivitis ligneous:

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Genes related to conjunctivitis ligneous according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PLG	plasminogen	11.0
2	ELANE	elastase, neutrophil expressed	11.0

Pathways related to conjunctivitis ligneous according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion_Cell-matrix glycoconjugates41	9.1	PLG, ELANE

Compounds related to conjunctivitis ligneous according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	benzamidine32 9 9	11.3	ELANE, PLG
2	epsilon aminocaproic acid32	9.3	ELANE, PLG
3	alginate32	9.3	ELANE, PLG
4	leupeptin32	9.2	PLG, ELANE
5	captopril32 42 9 9	12.2	ELANE, PLG
6	kininogen32	9.1	PLG, ELANE
7	heparin32 9 18 9	12.1	PLG, ELANE
8	aprotinin32 9 9	11.0	ELANE, PLG
9	fibrinogen32	8.8	ELANE, PLG

Biological processes related to conjunctivitis ligneous according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:006508	9.1	PLG, ELANE
2	extracellular matrix disassembly	GO:022617	9.0	PLG, ELANE
3	extracellular matrix organization	GO:030198	8.8	PLG, ELANE

Molecular functions related to conjunctivitis ligneous according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:004252	9.1	PLG, ELANE