MCID: CNJ014
MIFTS: 21

Conjunctivitis Ligneous malady

Rare diseases, Eye diseases categories

Aliases & Classifications for Conjunctivitis Ligneous

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Sources:
45NIH Rare Diseases, 47Novoseek, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
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Aliases & Descriptions for Conjunctivitis Ligneous:

Name: Conjunctivitis Ligneous 45
Ligneous Conjunctivitis 51 65
 
Conjunctivitis, Ligneous 47
Conjunctivitis Lignosa 51


Classifications:

Orphanet: 51 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

51
ligneous conjunctivitis:
Inheritance: Autosomal recessive; Age of onset: Childhood; Age of death: any age


External Ids:

Orphanet51 97231
ICD10 via Orphanet28 H10.4
UMLS via Orphanet66 C1274789

Summaries for Conjunctivitis Ligneous

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NIH Rare Diseases:45 Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. a systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. the cause of ligneous conjunctivitis is unknown. autosomal recessive inheritance has been suggested in some cases. ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency. last updated: 4/29/2013

MalaCards based summary: Conjunctivitis Ligneous, also known as ligneous conjunctivitis, is related to conjunctivitis and congenital plasminogen deficiency. An important gene associated with Conjunctivitis Ligneous is PLG (Plasminogen), and among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. Affiliated tissues include trachea, cervix and eye, and related mouse phenotype tumorigenesis.

Related Diseases for Conjunctivitis Ligneous

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Diseases related to Conjunctivitis Ligneous via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis10.6
2congenital plasminogen deficiency10.4
3plasminogen deficiency, type i10.2
4immunoglobulin a deficiency 210.2
5hemophilia b10.2
6hemophilia a10.2
7crohn's disease10.2
8hydrocephalus10.2
9skin conditions10.2
10skin disease10.2
11factor viii deficiency10.2
12infertility10.2
13spiradenoma10.2
14conjunctival disease10.2
15eye disease10.2
16globe disease10.2
17hydrocele10.2
18nutritional deficiency disease10.2
19periodontitis10.2
20skin tag10.2
21hemophilia10.2
22dissociative disorder9.8ELANE, PLG
23conjunctivitis with pseudomembrane9.7ELANE, PLG

Graphical network of the top 20 diseases related to Conjunctivitis Ligneous:



Diseases related to conjunctivitis ligneous

Symptoms for Conjunctivitis Ligneous

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Drugs & Therapeutics for Conjunctivitis Ligneous

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Drugs for Conjunctivitis Ligneous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1TetrahydrozolinePhase 2, Phase 3484
2PlasminogenPhase 2, Phase 3177

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis PatientsRecruitingNCT01554956Phase 2, Phase 3

Search NIH Clinical Center for Conjunctivitis Ligneous

Genetic Tests for Conjunctivitis Ligneous

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Anatomical Context for Conjunctivitis Ligneous

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MalaCards organs/tissues related to Conjunctivitis Ligneous:

33
Trachea, Cervix, Eye

Animal Models for Conjunctivitis Ligneous or affiliated genes

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MGI Mouse Phenotypes related to Conjunctivitis Ligneous:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1ELANE, PLG

Publications for Conjunctivitis Ligneous

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Variations for Conjunctivitis Ligneous

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Expression for genes affiliated with Conjunctivitis Ligneous

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Search GEO for disease gene expression data for Conjunctivitis Ligneous.

Pathways for genes affiliated with Conjunctivitis Ligneous

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Pathways related to Conjunctivitis Ligneous according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ELANE, PLG
2
Show member pathways
9.1ELANE, PLG
39.1ELANE, PLG
49.1ELANE, PLG

GO Terms for genes affiliated with Conjunctivitis Ligneous

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Cellular components related to Conjunctivitis Ligneous according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.1ELANE, PLG

Biological processes related to Conjunctivitis Ligneous according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:00226179.1ELANE, PLG
2extracellular matrix organizationGO:00301989.1ELANE, PLG
3proteolysisGO:00065088.8ELANE, PLG

Molecular functions related to Conjunctivitis Ligneous according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.1ELANE, PLG

Sources for Conjunctivitis Ligneous

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet