MCID: CNN010
MIFTS: 29

Connective Tissue Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Connective Tissue Benign Neoplasm

MalaCards integrated aliases for Connective Tissue Benign Neoplasm:

Name: Connective Tissue Benign Neoplasm 12 14
Soft Tissue Neoplasms 41 69
Soft Tissue Benign Neoplasm 12
Neoplasm of Soft Tissues 12
Tumor of the Soft Tissue 12
Neoplasm of Soft Tissue 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060123
MeSH 41 D012983
NCIt 46 C3377
SNOMED-CT 64 126600002 387837005
UMLS 69 C0037579

Summaries for Connective Tissue Benign Neoplasm

Disease Ontology : 12 A musculoskeletal system benign neoplasm that is located in connective tissue.

MalaCards based summary : Connective Tissue Benign Neoplasm, also known as soft tissue neoplasms, is related to infantile myofibromatosis and gastrointestinal stromal tumor. An important gene associated with Connective Tissue Benign Neoplasm is MDM2 (MDM2 Proto-Oncogene). Affiliated tissues include connective tissue, and related phenotypes are behavior/neurological and integument

Related Diseases for Connective Tissue Benign Neoplasm

Diseases in the Connective Tissue Cancer family:

Connective Tissue Benign Neoplasm

Diseases related to Connective Tissue Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 infantile myofibromatosis 31.7 CARMIL2 NDRG4 PDGFRB
2 gastrointestinal stromal tumor 29.7 ENO2 PDGFRB SYP
3 bone benign neoplasm 28.4 CDC73 ENO2 ERCC6 GNAS KDM7A RASAL1
4 glomangiosarcoma 10.9
5 nodular ganglioneuroblastoma 10.5 ENO2 MDM2
6 conventional fibrosarcoma 10.5 ENO2 MDM2
7 juvenile ossifying fibroma 10.5 MDM2 RASAL1
8 chondroid lipoma 10.5 ENO2 MDM2
9 anaplastic ependymoma 10.4 MDM2 SYP
10 juxtacortical osteosarcoma 10.4 GNAS MDM2
11 malignant sertoli cell tumor 10.4 ENO2 SYP
12 urinary bladder small cell neuroendocrine carcinoma 10.4 ENO2 SYP
13 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
14 auditory system cancer 10.4 ENO2 SYP
15 cutaneous ganglioneuroma 10.4 ENO2 SYP
16 sensory organ benign neoplasm 10.4 ENO2 SYP
17 middle ear adenoma 10.4 ENO2 SYP
18 gallbladder small cell carcinoma 10.4 ENO2 SYP
19 pancreatic somatostatinoma 10.4 ENO2 SYP
20 childhood oligodendroglioma 10.4 MDM2 SYP
21 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
22 small cell carcinoma of the bladder 10.4 ENO2 SYP
23 papillary tumor of the pineal region 10.4 ENO2 SYP
24 orbital cancer 10.4 ENO2 SYP
25 ovarian carcinosarcoma 10.4 ENO2 SYP
26 pulmonary large cell neuroendocrine carcinoma 10.4 ENO2 SYP
27 atypical follicular adenoma 10.4 ENO2 SYP
28 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 SYP
29 cerebellum cancer 10.3 ENO2 SYP
30 subependymal glioma 10.3 ENO2 SYP
31 olfactory nerve neoplasm 10.3 ENO2 SYP
32 cerebral neuroblastoma 10.3 ENO2 SYP
33 cauda equina neoplasm 10.3 ENO2 SYP
34 extraosseous chondrosarcoma 10.3 ENO2 SYP
35 benign ependymoma 10.3 ENO2 SYP
36 malignant teratoma 10.3 ENO2 SYP
37 astroblastoma 10.3 ENO2 SYP
38 ischemic fasciitis 10.3 MDM2 USP6
39 cerebral ventricle cancer 10.3 ENO2 SYP
40 cerebrum cancer 10.3 ENO2 SYP
41 pineal gland cancer 10.3 ENO2 SYP
42 endometrial small cell carcinoma 10.3 ENO2 SYP
43 melanotic neuroectodermal tumor 10.3 ENO2 SYP
44 subependymoma 10.3 ENO2 SYP
45 supratentorial cancer 10.3 ENO2 SYP
46 mucinous ovarian cystadenoma 10.3 ENO2 SYP
47 pineocytoma 10.3 ENO2 SYP
48 angiomyoma 10.3 ENO2 SYP
49 gastric squamous cell carcinoma 10.3 ENO2 SYP
50 gastric small cell carcinoma 10.3 ENO2 SYP

Graphical network of the top 20 diseases related to Connective Tissue Benign Neoplasm:



Diseases related to Connective Tissue Benign Neoplasm

Symptoms & Phenotypes for Connective Tissue Benign Neoplasm

MGI Mouse Phenotypes related to Connective Tissue Benign Neoplasm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 MDM2 NDRG4 PDGFRB SYP CARMIL2 CDC73
2 integument MP:0010771 9.7 GNAS KDM7A MDM2 PDGFRB CARMIL2 CDC73
3 limbs/digits/tail MP:0005371 9.35 GNAS KDM7A MDM2 PDGFRB ERCC6
4 nervous system MP:0003631 9.23 GNAS MDM2 NDRG4 PDGFRB SYP CDC73

Drugs & Therapeutics for Connective Tissue Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Connective Tissue Benign Neoplasm

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: soft tissue neoplasms

Genetic Tests for Connective Tissue Benign Neoplasm

Anatomical Context for Connective Tissue Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Connective Tissue Benign Neoplasm:

18
Connective Tissue

Publications for Connective Tissue Benign Neoplasm

Articles related to Connective Tissue Benign Neoplasm:

(show all 20)
# Title Authors Year
1
Soft Tissue Neoplasms Causing Apparent Venous Thoracic Outlet Syndrome. ( 28259825 )
2017
2
Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. ( 23332867 )
2013
3
Extranodal Rosai-Dorfman disease: a rare soft tissue neoplasm masquerading as a sarcoma. ( 23497062 )
2013
4
Intrathoracic chest wall lipoma: mimicking a soft tissue neoplasm on a chest radiograph. ( 24298118 )
2013
5
Primary cutaneous actinomycosis of upper extremity masquerading as soft tissue neoplasm: a case report. ( 22290111 )
2012
6
Cytopathological diagnosis of alveolar soft part sarcoma, a rare soft tissue neoplasm. ( 20731695 )
2011
7
Small-cell plasmacytoma with prominent myxoid stroma mimicking a soft-tissue neoplasm. ( 19776088 )
2009
8
The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms. ( 18162764 )
2008
9
Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. ( 18019405 )
2007
10
Divergent differentiation in malignant soft tissue neoplasms: the paradigm of liposarcoma and malignant peripheral nerve sheath tumor. ( 15735851 )
2005
11
Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities. ( 15716237 )
2005
12
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. ( 16160477 )
2005
13
Neurofibromatous changes in dermatofibrosarcoma protuberans: a potential pitfall in the diagnosis of a serious cutaneous soft tissue neoplasm. ( 15239679 )
2004
14
Cutaneous sclerosing perineurioma of the digits: an uncommon soft-tissue neoplasm. Report of two cases with immunohistochemical analysis. ( 14507408 )
2003
15
Epithelioid sarcoma: a puzzling soft tissue neoplasm in a child. ( 10773716 )
2000
16
Parachordoma: a clinicopathologic and immunohistochemical study of four cases of an unusual soft tissue neoplasm. ( 9869820 )
1997
17
Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. ( 1497116 )
1992
18
Extragenital granuloma inguinale mimicking a soft-tissue neoplasm: a case report and review of the literature. ( 1692564 )
1990
19
Case report 488: Post-traumatic myositis ossificans mimicking a soft tissue neoplasm. ( 3212498 )
1988
20
Pyomyositis mimicking soft tissue neoplasm in a child. ( 2960777 )
1987

Variations for Connective Tissue Benign Neoplasm

Copy number variations for Connective Tissue Benign Neoplasm from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13803 1 1 56100000 Amplification Soft tissue tumor
2 21057 1 156500000 172900000 Amplification Soft tissue tumor
3 151970 20 27500000 41700000 Amplification Soft tissue tumor
4 178515 3 74200000 91000000 Amplification Soft tissue tumor
5 206336 6 139000000 161000000 Amplification Soft tissue tumor

Expression for Connective Tissue Benign Neoplasm

Search GEO for disease gene expression data for Connective Tissue Benign Neoplasm.

Pathways for Connective Tissue Benign Neoplasm

GO Terms for Connective Tissue Benign Neoplasm

Biological processes related to Connective Tissue Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to toxic substance GO:0009636 8.8 ERCC6 MDM2 PDGFRB

Sources for Connective Tissue Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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