Connective Tissue Disease malady

MedlinePlus: Connective tissue is the material inside your body that supports many of its parts. it is the "cellular glue" that gives your tissues their shape and helps keep them strong. it also helps some of your tissues do their work. cartilage and fat are examples of connective tissue. there are over 200 disorders that impact connective tissue. some, like cellulitis, are the result of an infection. injuries can cause connective tissue disorders, such as scars. others, such as ehlers-danlos syndrome, marfan syndrome, and osteogenesis imperfecta, are genetic. still others, like scleroderma, have no known cause. each disorder has its own symptoms and needs different treatment.²³

MalaCards: Connective Tissue Disease, also known as connective tissue disorders, is related to mixed connective tissue disease and pulmonary hypertension. An important gene associated with Connective Tissue Disease is MFAP2 (microfibrillar-associated protein 2), and among its related pathways are Inhibition of Angiogenesis by TSP1 and ECM-receptor interaction. The compounds cyclophosphamide and dmso have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and myeloid, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology: A tissue disease that affects tissues such as skin, tendons, and cartilage.⁶

Wikipedia: A connective tissue disease is any disease that has the connective tissues of the body as a target of...⁴⁴ more...

Aliases & Descriptions:

connective tissue disease 6 44 8 connective tissue disorders 17 23 connective tissue diseases 32 43 disorder of connective tissue (disorder) 6

other musculoskelet/connectiv 6 connective tissue disorder 6 connective tissue dis. 6

Diseases related to connective tissue disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1052)

id	Related Disease	Score	Top Affiliating Genes
1	mixed connective tissue disease	38.8	PIK3C2A, SERPINH1, VDAC1, BMPR2, MUC16, S100A8
2	pulmonary hypertension	33.4	BMPR2, TNC, EDN1, EDNRA, ACVRL1, ELN
3	arthritis	31.7	SELL, MMP3, IL17A, IL1A, IL6, TNF
4	ehlers-danlos syndrome	31.4	CD36, COL3A1, COL5A1
5	cutis laxa	30.4	BMP6, ATP7A, CD79A, CD40LG, FBLN5, FBN1
6	rheumatoid arthritis	30.2	CD40, MICA, IL10, IL2, IL23A, HLA-DQA1
7	occipital horn syndrome	30.1	ATP7A, LOX, ELN
8	funisitis	29.9	S100A8, IL10, IL6, CRP
9	autoimmune hepatitis	29.6	CD40LG, F2, HSPG2, HSPD1, HLA-A, HLA-DRB1
10	castleman's disease	29.1	B2M, IL10, IL6, F8, F3, ALB
11	marfan syndrome	29.1	BMP6, CD36, FBN1, FBN2, LOX, COL1A2
12	scleritis	28.7	IL4, CCL2, IFNG, HLA-B, TNF, TNFRSF1B
13	primary biliary cirrhosis	28.7	SELL, CENPB, CD79A, CD40LG, FOXP3, ENO1
14	behcet's disease	28.7	SELE, SELL, IL2RA, APOH, ENO1, HSPG2
15	diabetic ketoacidosis	28.5	PIK3C2A, VWF, INS, IL10, IL6, ICAM1
16	antiphospholipid syndrome	28.2	VWF, SELE, VCAM1, CD79A, CD40LG, APOH
17	pemphigus foliaceus	28.1	CD79A, CD40LG, CD19, CD40, IL10, IL1A
18	epidermolysis bullosa	27.8	SERPINH1, CD79A, CD36, MMP3, IL2RA, FBN1
19	hepatitis	27.8	FASLG, F2, ALB, HLA-A, HLA-DRB1, LTF
20	multiple sclerosis	27.5	CD40, MICA, IL1A, IL2RA, IFNG, ICAM1
21	bronchiolitis obliterans	26.9	PIK3C2A, SFTPD, BMP6, IL10, IL17A, IL23A
22	spasticity	26.5	SERPINH1, B2M, CD4, FOXP3, INS, IL10
23	systemic scleroderma	26.5	SFTPD, SELE, CENPB, CENPC1, CD40LG, CD19
24	systemic lupus erythematosus	26.2	VWF, SELE, SERPINH1, VCAM1, BLZF1, S100A6
25	polycystic kidney disease	25.8	PIK3C2A, SELE, CD79A, INS, FBN1, FBN2
26	stickler syndrome	25.7	INS, IL10, IL2, IL2RA, IL4, IL6
27	polymyositis	25.2	PIK3C2A, VWF, SFTPD, SELE, VCAM1, S100A8
28	immunodeficiency	24.8	SELL, BMP6, BLZF1, LGALS1, CD79A, CD4
29	inflammatory bowel disease	24.6	SELE, SELL, VCAM1, LGALS1, S100A8, S100A9
30	synovitis	23.6	SELE, VCAM1, S100A8, S100A9, B2M, MPO
31	dermatomyositis	23.4	PIK3C2A, VWF, SFTPD, SELE, VCAM1, BMP6
32	pemphigus	23.3	BLZF1, CD79A, CD40LG, CD19, CD40, IL10
33	myasthenia gravis	23.2	LGALS1, CD79A, CD86, CD40LG, CD80, MMP3
34	vasculitis	23.0	VWF, SELE, SELL, VCAM1, BMP6, BLZF1
35	hypertension	22.9	PIK3C2A, VWF, SELE, SELL, VCAM1, BMP6
36	homocysteine	22.0	PIK3C2A, VWF, SELE, VCAM1, CD36, CD40LG
37	purpura	20.9	VWF, SELE, VCAM1, BMP6, S100A8, MPO
38	pulmonary fibrosis	20.3	VWF, SFTPD, SELE, SERPINH1, BMP6, S100A9
39	thrombosis	20.3	PIK3C2A, VWF, SELE, SELL, VCAM1, LGALS1
40	lupus erythematosus	20.2	PIK3C2A, VWF, SFTPD, SELE, SELL, SERPINH1
41	sarcoidosis	19.8	PIK3C2A, SFTPD, SELE, SELL, VCAM1, S100A8
42	atherosclerosis	18.6	PIK3C2A, VWF, SELE, SELL, VCAM1, BMP6
43	pneumonia	18.3	PIK3C2A, SFTPD, SELE, SELL, SERPINH1, VDAC1
44	pancreatitis	16.0	PIK3C2A, VWF, SELE, SERPINH1, VDAC1, VCAM1
45	erythema nodosum, idiopathic	14.2	S100A8, S100A9, HSPD1, TNF
46	telangiectasis	14.1	BMP6, BMPR2, CENPB, ACVRL1
47	osteogenesis imperfecta type 4	14.1	CD36, COL1A1, COL1A2, DSPP
48	dry eye syndrome	14.1	LGALS1, IL6, HSPG2, CALR, SSB, LTF
49	cervical incompetence	14.1	SERPINH1, LEPRE1, IL6, TNXB, COL5A1
50	calcinosis	14.1	PIK3C2A, CENPB, FBN1, HLA-DQA1, HLA-DRB1, TNF

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to connective tissue disease:

²²

MGI Mouse Phenotypes related to connective tissue disease:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	ATP7A, FBLN5, FBN1, HPRT1, PTPRC, COL3A1
2	craniofacial phenotype	MP:0005382	10.4	EDN1, EDNRA, ACVRL1, DSPP, POSTN, ADAMTS2
3	renal/urinary system phenotype	MP:0005367	10.2	COL2A1, PKD1, C1QA, EDNRA, ABCC6, PLG
4	limbs/digits/tail phenotype	MP:0005371	10.1	CTGF, COL1A1, COL1A2, COL2A1, PKD1, HSPG2
5	embryogenesis phenotype	MP:0005380	9.8	CYCS, SSB, COL1A1, COL2A1, COL5A1, ACVRL1
6	hematopoietic system phenotype	MP:0005397	9.1	XRCC6, CD86, CD80, CD19, CD5, FOXP3
7	other phenotype	MP:0005395	8.9	ABCC6, PKD1, SPP1, PTGS2, HSPG2, FBN1
8	endocrine/exocrine gland phenotype	MP:0005379	8.8	POSTN, EDNRA, CTLA4, HPRT1, IFNG, FASLG
9	adipose tissue phenotype	MP:0005375	8.6	TNFRSF1B, PTGS2, SNRPN, COL1A1, ACE, TGFB1
10	skeleton phenotype	MP:0005390	8.6	BMP6, BMPR2, LEPRE1, ATP7A, MMP3, FN1
11	no phenotypic analysis	MP:0003012	8.3	HLA-C, TP53, PTGS2, PPIB, PLOD1, COL1A1
12	muscle phenotype	MP:0005369	8.2	LGALS1, TP53, TNF, TNFRSF1B, PTGS2, SPP1
13	digestive/alimentary phenotype	MP:0005381	7.8	VWF, B2M, CD36, CD4, CD19, EDN1
14	liver/biliary system phenotype	MP:0005370	7.7	IL6, IFNG, HSPG2, HPRT1, TRB@, TP53
15	integument phenotype	MP:0010771	7.7	LGALS1, LEPRE1, ATP7A, CD4, CD19, FOXP3
16	reproductive system phenotype	MP:0005389	7.3	HPRT1, TNF, PTGS2, SPP1, SNRPN, PLG
17	growth/size phenotype	MP:0005378	7.2	FBN1, COL1A1, COLQ, COL1A2, COL3A1, COL2A1
18	nervous system phenotype	MP:0003631	7.1	PLG, SPP1, CYCS, PTPRC, PTPN12, TNFRSF1B
19	vision/eye phenotype	MP:0005391	7.1	TP53, TNF, TNFRSF1B, PTGS2, CTGF, PLG
20	behavior/neurological phenotype	MP:0005386	6.9	SNRPN, SPP1, CYCS, TNFRSF1B, TNC, HLA-C
21	mortality/aging	MP:0010768	6.7	PIK3C2A, IL2RA, IL6, FBL, FBN1, FBN2
22	immune system phenotype	MP:0005387	5.8	VWF, SELL, LGALS1, XRCC6, ATP7A, CD79A
23	normal phenotype	MP:0002873	5.6	SNRPN, CTLA4, CTGF, PTPRC, PTGS2, TNC
24	tumorigenesis	MP:0002006	5.3	TRB@, TP53, TNF, TNFRSF1B, TNXB, PTGS2
25	cardiovascular system phenotype	MP:0005385	4.7	CRP, POSTN, CXCL10, TGFBR2, PLG, PLOD1
26	homeostasis/metabolism phenotype	MP:0005376	4.1	B2M, APOH, FASLG, CCL2, CCK, LOX
27	cellular phenotype	MP:0005384	2.5	HSPG2, COL1A1, COL1A2, PKD1, C1QA, ACE

Articles related to connective tissue disease:

(show top 50)    (show all 111)

id	Title	Authors	Year	Affiliating Genes
1	Heterogeneous pathogenic processes of thrombotic micr oangiopathies in patients with connective tissue diseases. (19652889)	Matsuyama T.... Fujimura Y.	2009	ADAMTS13
2	Pulmonary capillary endothelial metabolic dysfunction: severity in pulmonary arterial hypertension related to connective tissue disease versus idiopathic pulmonary arterial hypertension. (18383374)	Langleben D.... Catravas J.D.	2008	ACE
3	Human voltage-dependent anion selective channel 1 is a target antigen for antiglomerular endothelial cell antibody in mixed connective tissue disease. (18568384)	Kikuchi T.... Oite T.	2008	VDAC1
4	Vitamin D deficiency in undifferentiated connective tissue disease. (18928561)	Zold E.... Bodolay E.	2008	INS
5	Is sitaxsentan a good therapeutic option for pulmonar y arterial hypertension associated with connective tissue disease? (18382424)	Allanore Y.	2008	EDNRA
6	CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease. (18523312)	Greidinger E.L.... Hoffman R.W.	2008	SNRNP70, HLA-DRB4, TRB@
7	Association of autoantibodies with Ku and DNA repair proteins in connective tissue diseases. (18208821)	Schild-Poulter C.... Hache R.J.	2008	XRCC6
8	Mutations of activin-receptor-like kinase 1 (ALK-1) are not found in patients with pulmonary hypertension and underlying connective tissue disease. (16941203)	Selva-O'Callaghan A.... Ordi-Ros J.	2007	ACVRL1
9	The role of endothelin in connective tissue diseases. (16987839)	Sticherling M.	2006	EDN1
10	Lack of circulating autoantibodies to bone morphogenetic protein receptor-II or activin receptor-like kinase 1 in mixed connective tissue disease patients with pulmonary arterial hypertension. (15509626)	Satoh T.... Kuwana M.	2005	BMPR2, ACVRL1
11	TNF-alpha inhibitors in systemic vasculitides and connective tissue diseases. (15652776)	Lamprecht P.	2005	TNF
12	Autoimmune response to proteasome activator 28alpha in patients with connective tissue diseases. (14760793)	Matsushita M.... Hashimoto H.	2004	PSME3, PSME1
13	Vascular and connective tissue diseases in the paedia tric world. (14994998)	Falcini F.	2004	APOH
14	Anticyclic citrullinated peptide antibodies in patients with mixed connective tissue disease. (17143695)	Takasaki Y.... Hashimoto H.	2004	HSPG2
15	Abnormalities of serum antielastin antibodies in connective tissue diseases. (12643515)	Colburn K.K.... Green L.M.	2003	ELN
16	MICA4/HLA-DRB1*04/TNF1 haplotype is associated with mixed connective tissue disease in Swedish patients. (12559632)	Hassan A.B.... Sanjeevi C.B.	2003	TNF, HLA-DRB1, MICA
17	Detection of anti-early endosome antigen 1 antibody in sera showing cytoplasmic vesicular staining, taken from patients with connective tissue diseases (12884735)	Miyachi K.... Fritzler M.J.	2003	EEA1
18	Increased levels of tumor necrosis alpha and soluble vascular endothelial adhesion molecule-1 in the cerebrospinal fluid of patients with connective tissue diseases and multiple sclerosis. (14750436)	Baraczka K.... NAckA!m K.	2003	TNF
19	Von Willebrand factor cleaving protease (ADAMTS-13) in 123 patients with connective tissue diseases (systemic lupus erythematosus and systemic sclerosis). (12935979)	Mannucci P.M.... Scorza R.	2003	ADAMTS13
20	Anti-lactoferrin antibodies in patients with connective tissue diseases. (15272812)	Manolova I.M.	2003	LTF
21	Antiphospholipid syndrome in patients with systemic connective tissue diseases (12794367)	Unikiene D.... MisiAniene N.	2003	APOH
22	Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease. (12659832)	Yokota S.... Nagata K.	2003	SERPINH1
23	Autoantibodies directed against the amino-terminal domain I of human calpastatin (ACAST-DI Ab) in connective tissue diseases. High levels of ACAST-DI Ab are associated with vasculitis in lupus. (12367559)	Saulot V.... Gilbert D.	2002	CAST
24	Autoantibodies to the 27 C-terminal amino acids of calpastatin are detected in a restricted set of connective tissue diseases and may be useful for diagnosis of rheumatoid arthritis in community cases of very early arthritis. (11600742)	Vittecoq O.... Tron F.	2001	CAST
25	Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four cases. (10943882)	Crofford L.J.... Schmaier A.H.	2000	PTGS2, APOH
26	Anticardiolipin antibodies after kidney transplantati on in patients without connective tissue disease. (10083086)	GrandtnerovA! B.... ZarnovicanovA! M.	1999	APOH
27	Soluble intercellular adhesion molecule-1 in paediatric connective tissue diseases. (10342537)	Laucella S.A.... Cuttica R.J.	1999	ICAM1
28	Mixed connective tissue disease--etiology, pathogenesis, clinical significance, treatment (10645148)	Zdrojewicz Z.... PuA8awska J.	1999	RNPC3
29	Analysis of human T cell and B cell responses against U small nuclear ribonucleoprotein 70-kd, B, and D polypeptides among patients with systemic lupus erythematosus and mixed connective tissue disease. (9259431)	Holyst M.M.... Hoffman R.W.	1997	RNPC3
30	D-penicillamine-induced pemphigus foliaceus with autoantibodies to desmoglein-1 in a patient with mixed connective tissue disease. (9216536)	PeA+as P.F.... Diaz L.A.	1997	DSG1
31	Eosinophilic vasculitis in connective tissue disease. (8708015)	Chen K.R.... Leiferman K.M.	1996	PRG2
32	Elevated serum prolactin or elevated prolactin/cortisol ratio are associated with autoimmune processes in systemic lupus erythematosus and other connective tissue diseases. (8832986)	Neidhart M.	1996	PRL
33	Changes in elastase and collagenase serum levels in patients with sclerosing connective tissue diseases treated with uropancreozymi n (8689664)	HodA!c V.... Svatos A.	1996	CCK
34	Seroprevalence of Helicobacter pylori infection in patients with connective tissue diseases. (8865155)	Showji Y.... Suzuki H.	1996	S100A9
35	Von Willebrand factor antigen in assessment of vasculitis in patients with connective tissue diseases. (8187441)	Kloczko J.... Radziwon P.	1994	VWF
36	The association of myasthenia gravis and connective tissue diseases--the role of SjA,gren's syndrome. (8144128)	Yasuda M.... Nobunaga M.	1994	HSPG2
37	Mixed connective tissue disease associated with multi centric Castleman's disease. (8091149)	Nanki T.... Arai S.	1994	IL6
38	Different distribution of T cell receptor beta-chain haplotypes in mixed connective tissue disease and systemic lupus erythematosus. (7912940)	IkAoheimo I.L.... Silvennoinen-Kassinen S.H.	1994	TRB@
39	Mixed connective tissue disease and SjAPgren's syndrome, accompanied by HTLV-I infection. (8101109)	Matsumoto Y.... Sato K.	1993	HSPG2
40	Difference in HLA-linked genetic background between mixed connective tissue disease and systemic lupus erythematosus. (8456439)	Dong R.P.... Sasazuki T.	1993	HLA-DQA1, HLA-DRB1, HLA-DPB1
41	Protein-losing enteropathy and pancreatic involvement in a case of connective tissue disease. (1577230)	Kashihara T.... Okuno G.	1992	ALB
42	Mixed connective tissue disease associated with protein losing enteropathy: successful treatment with intravenous cyclophosphamide therapy. (1300171)	Furuya T.... Kashiwazaki S.	1992	MUC16
43	Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies. (1472125)	Ranki A.... Stephansson E.	1992	IL2RA
44	IgG and IgM anti-snRNP reactivity in sequentially obtained serum samples from patients with connective tissue diseases. (1485812)	Nyman U.... Pettersson I.	1992	RNPC3
45	Urticarial vasculitis in a connective tissue disease clinic: patterns, presentations, and treatment. (2068575)	Asherson R.A.... Hughes G.R.	1991	C1S
46	Association of mixed connective tissue disease, SjAPgren's syndrome and autoimmune hepatitis: report of a case. (1920970)	Wada T.... Nakanuma Y.	1991	HSPG2
47	Antibody responses against polypeptide components of Epstein-Barr virus-induced early diffuse antigen in patients with connective tissue diseases. (2173736)	Ngou J.... Graafland H.	1990	COLQ
48	Autoantibody production against the U small nuclear ribonucleoprotein particle proteins E, F and G in patients with connective tissue diseases. (2138085)	Reuter R.... Luhrmann R.	1990	LSM2
49	Clinical screening for collagen defects in connective tissue diseases. (2286029)	Cohn D.H.... Byers P.H.	1990	CD36
50	Myeloid calcium binding proteins: expression in the differentiated HL-60 cells and detection in sera of patients with connective tissue diseases. (2292594)	Kuruto R.... Takasaki Y.	1990	S100A8, S100A9, S100A6

Genes related to connective tissue disease according to GeneCards:

(show top 50)    (show all 154)

id	Symbol	Description	Score	GeneCards Section Context
1	MFAP2	microfibrillar-associated protein 2	11.1	Summaries
2	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
3	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
4	FBN1	fibrillin 1	11.0	Publications
5	ACVRL1	activin A receptor type II-like 1	11.0	Publications
6	BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	11.0	Publications
7	S100A9	S100 calcium binding protein A9	11.0	Publications
8	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
9	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
10	LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	11.0	Publications
11	CENPB	centromere protein B, 80kDa	11.0	Publications
12	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
13	PRTN3	proteinase 3	11.0	Publications
14	SNRPA	small nuclear ribonucleoprotein polypeptide A	11.0	Publications
15	HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	11.0
16	SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	11.0	Publications
17	DSG1	desmoglein 1	11.0	Publications
18	FBL	fibrillarin	11.0	Publications
19	EDNRA	endothelin receptor type A	11.0	Publications
20	S100A8	S100 calcium binding protein A8	11.0	Publications
21	POLR1C	polymerase (RNA) I polypeptide C, 30kDa	11.0
22	HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	11.0	Publications
23	TRB@	T cell receptor beta locus	11.0	Publications
24	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0
25	HLA-A	major histocompatibility complex, class I, A	11.0
26	MOXD2P	monooxygenase, DBH-like 2, pseudogene	11.0	Publications
27	RNASEH2A	ribonuclease H2, subunit A	11.0
28	SSB	Sjogren syndrome antigen B (autoantigen La)	11.0	Publications
29	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	11.0	Publications
30	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.0	Publications
31	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	11.0	Publications
32	FBLN5	fibulin 5	11.0
33	SNRPD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa	11.0
34	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
35	PEPD	peptidase D	11.0
36	MUC16	mucin 16, cell surface associated	11.0	Publications
37	MICA	MHC class I polypeptide-related sequence A	11.0	Publications
38	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	11.0	Publications
39	LOX	lysyl oxidase	11.0
40	PKD1	polycystic kidney disease 1 (autosomal dominant)	11.0
41	PLOD1	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	11.0
42	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	11.0
43	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
44	ENO1	enolase 1, (alpha)	11.0
45	ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	11.0
46	SFTPD	surfactant protein D	11.0	Publications
47	TNXB	tenascin XB	11.0
48	CTGF	connective tissue growth factor	11.0
49	COL1A2	collagen, type I, alpha 2	11.0
50	COL3A1	collagen, type III, alpha 1	11.0

Pathways related to connective tissue disease according to GeneDecks:

(show top 50)    (show all 128)

id	Pathway	Score	Top Affiliating Genes
1	Inhibition of Angiogenesis by TSP136	10.5	FBN2, FBN1, FN1, CD36, COL2A1, COL5A1
2	ECM-receptor interaction20	10.4	SPP1, COL1A1, COL1A2, COL2A1, TNXB, TNC
3	Staphylococcus aureus infection20	10.4	C1QA, C1S, DSG1, IL10, PLG, HLA-DRB4
4	ILK Signaling36	10.3	HSPG2, FBN1, PRG2, FN1, ELN, FBN2
5	FAK1 Signaling36	10.3	COL2A1, FBN1, COL3A1, HSPG2, TNC, SPP1
6	UPA-UPAR Pathway36	10.3	COL1A2, COL1A1, PLG, SPP1, TNC, HSPG2
7	Antigen processing and presentation20	10.2	PSME3, HLA-DRB4, HLA-DRB1, HLA-DQA1, HLA-DPB1, HLA-C
8	Asthma20	10.2	PRG2, TNF, HLA-DRB4, HLA-DRB1, HLA-DPB1, IL4
9	Amoebiasis20	9.8	COL5A1, FN1, IL6, COL2A1, COL1A2, COL1A1
10	Hematopoietic cell lineage20	9.8	IL4, TNF, HLA-DRB4, HLA-DRB1, IL6, IL2RA
11	Systemic lupus erythematosus20	9.4	HLA-DRB1, HLA-DRB4, TRIM21, TNF, SSB, SNRPD3
12	Transendothelial Migration of Leukocytes36	9.4	ICAM1, PRG2, CXCL10, CCL2, FBN2, FBN1
13	Cell adhesion molecules (CAMs)20	9.4	CD40, CD4, CD86, SELL, HLA-DPB1, PTPRC
14	Viral myocarditis20	9.3	CD86, CD40LG, CD80, HLA-DRB1, CYCS, HLA-DRB4
15	African trypanosomiasis20	9.3	TNF, IL6, SELE, VCAM1, IL10, IFNG
16	Influenza A20	9.3	IFNG, HLA-DQA1, CCL2, FASLG, IL6, IL1A
17	Endothelin-1 Signaling Pathway36	9.2	EDNRA, CXCL10, CD80, IL10, IL1A, IL2
18	PGC1Alpha Pathway36	9.2	IL4, IL23A, IL2, IL1A, CD4, BMP6
19	Leishmaniasis20	9.2	PTGS2, TGFB1, TNF, HLA-DRB4, HLA-DQA1, HLA-DRB1
20	Immune response IL-22 signaling pathway10	9.1	TRB@, HLA-DRB4, HLA-DRB1, HLA-DPB1, IL2RA, IL2
21	Tuberculosis20	9.1	EEA1, IL6, HSPD1, HLA-DPB1, HLA-DQA1, HLA-DRB1
22	THC Differentiation Pathway36	9.1	IL10, CD86, IL2, IL2RA, IL4, IFNG
23	PTEN Pathway36	9.0	FN1, COL1A2, COL1A1, CTGF, FBN2, TNC
24	Graft-versus-host disease20	9.0	HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB4, HLA-A
25	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.9	TNFRSF1B, FOXP3, IL10, IL2, IL2RA, TNF
26	Phospholipase-C Pathway36	8.8	COL2A1, IL2, FN1, BMP6, CD79A, TGFB1
27	MIF Regulation of Innate Immune Cells36	8.8	CCL2, IL4, TNF, PTGS2, CXCL10, PF4
28	MIF Mediated Glucocorticoid Regulation36	8.8	IL6, PTGS2, TNF, CCL2, IL4, IL2
29	Rheumatoid arthritis20	8.8	IFNG, ICAM1, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-DRB4
30	all-trans-Retinoic Acid Signaling in Brain36	8.7	IL2, IL23A, IL4, IL6, PF4, BMP6
31	Intestinal immune network for IgA production20	8.7	TGFB1, HLA-DRB4, HLA-DRB1, HLA-DQA1, HLA-DPB1, IL6
32	STAT3 Pathway36	8.7	TNF, IL2, BMP6, BMPR2, CD4, CD80
33	Akt Signaling36	8.7	TNF, CTGF, IL23A, PF4, ACVRL1, CXCL10
34	Malaria20	8.6	CD36, VCAM1, SELE, CD40LG, CD40, IL10
35	PEDF Induced Signaling36	8.6	IL1A, IL2, CD80, IL10, BMP6, IL23A
36	ERK Signaling36	8.5	CXCL10, PRG2, TGFB1, PF4, COL5A1, COL2A1
37	Type I diabetes mellitus20	8.5	CD86, HLA-DRB1, HLA-DRB4, TNF, HLA-DQA1, HLA-DPB1
38	ICos-ICosL Pathway in T-Helper Cell36	8.4	CD4, IL2RA, PIK3C2A, PTPRC, CD80, CD86
39	Rho Family GTPases36	8.3	COL2A1, COL5A1, PF4, ELN, TGFB1, BMP6
40	MAPK Signaling36	8.2	IL2RA, TNFRSF1B, SPP1, CTGF, COL1A1, COL1A2
41	Chagas disease (American trypanosomiasis)20	8.2	IFNG, TNF, CCL2, ACE, TGFB1, TGFBR2
42	Autoimmune thyroid disease20	8.2	CD86, CD40LG, CD80, CD40, IL10, IL2
43	TGF-Beta Pathway36	8.0	IL2RA, IL23A, IL4, IL6, CCL2, IL1A
44	Antioxidant Action of Vitamin-C36	8.0	TNF, TNFRSF1B, CTGF, PF4, ACVRL1, TGFB1
45	Allograft rejection20	7.9	CD80, CD40, IL10, IL2, IL4, FASLG
46	Tec Kinases Signaling36	7.9	TNF, TGFB1, ACVRL1, TNFRSF1B, IL6, IL23A
47	Molecular Mechanisms of Cancer36	7.9	PRG2, TGFBR2, IL2, FN1, CD80, CD4
48	p38 Signaling36	7.4	TP53, CCL2, TNF, TNFRSF1B, CTGF, PF4
49	JAK-STAT Pathway36	7.2	IL2RA, BMP6, CD4, IL10, IL1A, IL4
50	Cytokine-cytokine receptor interaction20	7.1	CD40LG, BMPR2, TNF, IFNG, CCL2, FASLG

Compounds related to connective tissue disease according to GeneDecks:

(show top 50)    (show all 428)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.7	APOH, F8, TRB@, LTF
2	dmso32	10.5	BMP6, S100A9, CD36, MMP3, F3, HSPG2
3	ionomycin32	10.2	CD40, CAST, CALR, PTPRC
4	ascorbic acid32 18	11.0	SERPINH1, LEPRE1, CD36, CD40LG, IL1A, IL2RA
5	endotoxin32	9.7	SFTPD, SELL, S100A8, S100A9, CD86, CD40
6	8-isoprostane32	9.7	SELE, VCAM1, MPO, INS, IL10, IL6
7	atp32	9.6	PIK3C2A, SERPINH1, VDAC1, BLZF1, S100A6, S100A9
8	oxygen32 18	10.5	PIK3C2A, SFTPD, VDAC1, BLZF1, LGALS1, S100A8
9	procollagen32	9.5	SERPINH1, BMP6, LGALS1, CD36, MMP3, IL1A
10	sulfasalazine32 9 9	11.5	SELE, MPO, CD79A, CD40LG, MMP3, IL1A
11	h2o232	9.3	VWF, SELL, VDAC1, BLZF1, MUC16, S100A9
12	zinc32 18	10.1	VDAC1, BLZF1, S100A6, S100A8, S100A9, ATP7A
13	atorvastatin32 34 9 18 9	13.0	PIK3C2A, VWF, SELE, SELL, VCAM1, BMP6
14	losartan32 34 9 9	11.9	VWF, SELE, VCAM1, BMP6, CD36, CCL2
15	allergens32	8.9	SFTPD, BLZF1, S100A8, CD79A, CD86, CD40LG
16	infliximab32 9 9	10.9	SELE, MMP3, IL10, IL17A, IL2RA, IL4
17	adenylate32	8.9	VWF, SELE, VDAC1, VCAM1, BLZF1, CD40LG
18	norepinephrine32 9 18 9	11.8	PIK3C2A, VWF, SELE, SELL, VCAM1, BMP6
19	polymyxin b32	8.8	SELE, VDAC1, VCAM1, IL10, IL1A, IL4
20	okt332	8.7	SELE, VCAM1, BMP6, CD79A, CD40LG, IL10
21	dextran sulfate32	8.6	SELE, SELL, VDAC1, MPO, CD36, CD4
22	pge232	8.6	SELE, VCAM1, CD86, CD4, ITIH4, MMP3
23	testosterone32 9 18 9	11.5	PIK3C2A, SELE, VCAM1, BLZF1, MUC16, S100A6
24	ly29400232	8.2	PIK3C2A, SELE, FN1, IL10, IL17A, IL4
25	pentoxifylline32 9 9	10.1	SELL, VCAM1, BMP6, MPO, IL10, IL1A
26	heparin32 9 18 9	11.1	PIK3C2A, VWF, LGALS1, MPO, CD79A, CD36
27	alanine32	8.1	PIK3C2A, VWF, SELE, SELL, VCAM1, BMP6
28	cysteine32	8.1	SFTPD, VDAC1, BLZF1, LGALS1, S100A6, S100A8
29	formaldehyde32 18	9.0	VWF, SELE, SELL, BLZF1, B2M, MPO
30	curcumin32	8.0	VCAM1, XRCC6, MMP3, IL17A, IL1A, IL6
31	phosphatidylinositol32	8.0	PIK3C2A, SFTPD, VDAC1, VCAM1, BMP6, BLZF1
32	simvastatin32 34 42 9 18 9	12.9	PIK3C2A, VWF, SELE, SELL, VCAM1, BMP6
33	oligonucleotide32	7.8	VWF, SFTPD, SERPINH1, VDAC1, BMP6, S100A6
34	neopterin32	7.5	B2M, CD79A, CD4, CD40LG, CD40, IL10
35	il 1032	7.1	BMP6, CD40, IL10, IL1A, IL2, IL2RA
36	histamine32 18	8.1	VWF, SFTPD, SELE, SELL, VCAM1, BMP6
37	cisplatin32 34 9 9	10.1	PIK3C2A, VDAC1, BMP6, BLZF1, MUC16, XRCC6
38	cholesterol32 9 18 9	10.1	PIK3C2A, VWF, SFTPD, SELE, VCAM1, BLZF1
39	vegf32	7.0	PIK3C2A, VWF, SELE, SERPINH1, VCAM1, MUC16
40	mycophenolate mofetil32 9 9	8.9	SELE, CD79A, CD36, CD40LG, CD40, IL10
41	polysaccharide32	6.8	SFTPD, SELE, SELL, VDAC1, VCAM1, BMP6
42	tacrolimus32 34 9 9	9.5	BMP6, CD79A, CD36, CD86, CD40, FN1
43	paraffin32	6.5	VWF, SELL, VCAM1, LGALS1, MUC16, S100A6
44	creatinine32	6.1	PIK3C2A, VWF, SELE, SELL, VDAC1, BMP6
45	thymidine32 18	7.0	SFTPD, VDAC1, BMP6, BMPR2, B2M, CD40
46	tyrosine32	5.9	PIK3C2A, VWF, SELL, SERPINH1, VDAC1, VCAM1
47	cyclosporin a32 42	6.8	PIK3C2A, VWF, SERPINH1, VDAC1, BLZF1, B2M
48	cycloheximide32	4.4	SELE, SELL, BMP6, BLZF1, B2M, CD36
49	dexamethasone32 42 34 9 9	8.3	VWF, SFTPD, SELL, VCAM1, BMP6, LGALS1
50	serine32	4.1	VWF, SFTPD, SELE, SELL, SERPINH1, VDAC1

Cellular components related to connective tissue disease according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	10.5	HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-DRB4
2	extracellular matrix	GO:031012	10.2	TNXB, COL1A1, COL1A2, COL3A1, COL5A1, PRTN3
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.1	HLA-DRB4, HLA-DRB1, HLA-DQA1, HLA-DPB1, HLA-C, HLA-B
4	ER to Golgi transport vesicle membrane	GO:012507	9.9	HLA-DRB4, HLA-DRB1, HLA-DQA1, HLA-DPB1, HLA-C, HLA-B
5	cell surface	GO:009986	9.8	ADAMTS13, TGFB1, ACVRL1, TNF, CALR, HSPD1
6	endoplasmic reticulum lumen	GO:005788	9.6	PPIB, COL1A1, COL1A2, COL3A1, COL2A1, COL5A1
7	MHC class I protein complex	GO:042612	9.6	HLA-C, HLA-B, HLA-A, MICA, B2M
8	proteinaceous extracellular matrix	GO:005578	9.5	LEPRE1, MMP3, FN1, FBLN5, FBN1, FBN2
9	membrane raft	GO:045121	9.3	EDNRA, PTPRC, TNFRSF1B, TNF, CD4, CD36
10	platelet alpha granule lumen	GO:031093	8.9	TGFB1, PF4, PLG, ALB, F8, FN1
11	integral to plasma membrane	GO:005887	8.5	HLA-DQA1, HLA-DRB1, HLA-DRB4, TNF, PTPRC, CTLA4
12	external side of plasma membrane	GO:009897	7.4	VWF, SELL, VCAM1, B2M, CD79A, CD36
13	plasma membrane	GO:005886	6.6	HLA-DRB4, HLA-DRB1, HLA-DQA1, HLA-DPB1, HLA-C, HLA-B
14	extracellular space	GO:005615	5.2	SFTPD, IL4, IL6, FBLN5, FBN1, APOH
15	extracellular region	GO:005576	5.0	IBSP, C1S, EDN1, TGFB1, PRL, PRG2

Biological processes related to connective tissue disease according to GeneDecks:

(show top 50)    (show all 66)

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen fibril organization	GO:030199	10.9	ADAMTS2, COL5A1, COL2A1, COL3A1, COL1A2, COL1A1
2	elastic fiber assembly	GO:048251	10.9	TNXB, LOX, FBLN5, ATP7A
3	collagen biosynthetic process	GO:032964	10.8	COL5A1, COL3A1, COL1A1, SERPINH1
4	cartilage development	GO:051216	10.7	TGFBR2, EDN1, PKD1, BMP6, ATP7A, COL2A1
5	extracellular matrix organization	GO:030198	10.6	SERPINH1, ADAMTS2, ELN, COL5A1, COL2A1, COL3A1
6	blood vessel development	GO:001568	10.6	TGFBR2, COL1A2, COL1A1, LOX, ATP7A
7	blood vessel remodeling	GO:001974	10.4	ELN, ACVRL1, ATP7A, BMPR2
8	positive regulation of interleukin-6 production	GO:032755	10.3	CD36, IL1A, IL6, HSPD1, TNF
9	detection of bacterium	GO:016045	10.1	HLA-A, HLA-B, HLA-DRB1, HLA-DRB4
10	T cell costimulation	GO:031295	10.1	CTLA4, HLA-DRB4, HLA-DRB1, HLA-DQA1, HLA-DPB1, CD5
11	negative regulation of T cell proliferation	GO:042130	10.1	TGFB1, HLA-DRB4, HLA-DRB1, IL10, FOXP3, SFTPD
12	positive regulation of MHC class II biosynthetic process	GO:045348	10.1	IFNG, IL4, IL10, CD40LG
13	acute-phase response	GO:006953	10.0	CRP, F2, F8, IL6, INS, FN1
14	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.0	CD86, CD4, CD80, IL1A
15	B cell proliferation	GO:042100	10.0	PTPRC, HSPD1, IL10, CD40, CD40LG, CD79A
16	maternal process involved in parturition	GO:060137	10.0	EDNRA, EDN1, CCL2
17	leukocyte cell-cell adhesion	GO:007159	10.0	PTPRC, ICAM1, CD40LG, VCAM1, SELE
18	B cell differentiation	GO:030183	10.0	PTPRC, IL4, IL10, CD40LG, CD79A, VCAM1
19	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	10.0	PSME3, PSME1, HLA-C, HLA-B, HLA-A, CALR
20	positive regulation of interleukin-12 production	GO:032735	10.0	HSPD1, IFNG, IL23A, CD40, CD40LG, CD36
21	positive regulation of nitric oxide biosynthetic process	GO:045429	10.0	EDN1, PTGS2, TNF, ICAM1, IFNG, INS
22	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	10.0	PSME3, PSME1, HLA-C, HLA-B, HLA-A, CALR
23	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.0	HLA-C, HLA-B, HLA-A, B2M
24	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	9.9	PSME3, PSME1, HLA-C, HLA-B, HLA-A, CALR
25	response to lipopolysaccharide	GO:032496	9.9	CXCL10, EDNRA, EDN1, PTGS2, F3, FASLG
26	cellular response to lipopolysaccharide	GO:071222	9.8	CD36, IL10, CCL2, IFNG, ICAM1, TNFRSF1B
27	response to hypoxia	GO:001666	9.8	TGFB1, EDNRA, EDN1, PLOD1, PLOD2, CRP
28	positive regulation of interferon-gamma production	GO:032729	9.8	TNF, HSPD1, IL23A, IL2, CD40LG
29	positive regulation of T cell proliferation	GO:042102	9.7	PTPRC, IFNG, IL6, IL4, IL23A, VCAM1
30	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	TP53, CCK, IL6, INS, CD80, CD4
31	response to wounding	GO:009611	9.6	TGFB1, CTGF, TNC, F2, FN1, VWF
32	defense response to virus	GO:051607	9.5	CXCL10, PTPRC, IFNG, IL6, MICA, CD40
33	response to gamma radiation	GO:010332	9.4	CXCL10, PTPRC, TP53, CCL2, IL1A
34	interferon-gamma-mediated signaling pathway	GO:060333	9.3	HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-DRB4, SP100, HLA-C
35	cell-cell signaling	GO:007267	9.2	CXCL10, EDN1, C1QA, FASLG, IL2, IL17A
36	platelet degranulation	GO:002576	9.1	TGFB1, PF4, PLG, ALB, F8, FN1
37	regulation of immune response	GO:050776	9.1	HLA-C, HLA-B, HLA-A, ICAM1, IL4, CD40
38	positive regulation of B cell proliferation	GO:030890	8.9	PTPRC, IL4, IL2, CD40, CD40LG
39	cytokine-mediated signaling pathway	GO:019221	8.9	HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-DRB4, SP100
40	positive regulation of cell proliferation	GO:008284	8.8	EDN1, EDNRA, TGFB1, TGFBR2, PRTN3, CXCL10
41	response to drug	GO:042493	8.8	TNF, PTGS2, EDN1, ABCC6, TOP1, TGFB1
42	positive regulation of isotype switching to IgG isotypes	GO:048304	8.8	PTPRC, IFNG, IL4, IL2, CD40
43	inflammatory response	GO:006954	8.8	CCL2, TNF, TNFRSF1B, PTGS2, SPP1, CRP
44	cell surface receptor signaling pathway	GO:007166	8.7	CXCL10, PRL, EDN1, PTPRC, F2, IFNG
45	virus-host interaction	GO:019048	8.7	HLA-C, TP53, SP100, RPLP0, TOP1, TGFB1
46	platelet activation	GO:030168	8.5	PLG, COL1A1, COL1A2, COL3A1, PF4, TGFB1
47	cell adhesion	GO:007155	8.4	ICAM1, IBSP, TNC, TNXB, SPP1, COL5A1
48	blood coagulation	GO:007596	7.9	TP53, PLG, COL1A1, COL1A2, PF4, TGFB1
49	immune response	GO:006955	7.9	HLA-C, HLA-DQA1, HLA-DRB1, HLA-DRB4, CTLA4, PF4
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.1	IL6, IFNG, TP53, TNF, PKD1, ACVRL1

Molecular functions related to connective tissue disease according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet-derived growth factor binding	GO:048407	10.5	COL5A1, COL2A1, COL3A1, COL1A2, COL1A1
2	integrin binding	GO:005178	10.3	CTGF, COL3A1, COL5A1, ADAMTS13, TNXB, CALR
3	extracellular matrix structural constituent	GO:005201	10.1	DSPP, ELN, COL5A1, COL3A1, COL1A2, COL1A1
4	glycoprotein binding	GO:001948	10.0	VWF, LGALS1, CD4, CD5, APOH
5	cell surface binding	GO:043498	9.8	PLG, HSPD1, F3, ICAM1
6	heparin binding	GO:008201	9.7	COL5A1, PF4, LTF, PRG2, POSTN, CTGF
7	protease binding	GO:002020	9.5	TNF, TP53, F3, INS, SELL
8	copper ion binding	GO:005507	9.0	TP53, ALB, F8, LOX, IL1A, MOXD2P
9	cytokine activity	GO:005125	8.4	IL6, FASLG, IFNG, TNF, SPP1, EDN1
10	protein binding	GO:005515	4.6	HNRNPC, SP100, CTLA4, PPIB, SNRPN, SNRPC