Aliases & Classifications for Connective Tissue Disease

MalaCards integrated aliases for Connective Tissue Disease:

Name: Connective Tissue Disease 12 14
Connective Tissue Diseases 51 41 69
Abnormality of Connective Tissue 28
Disorder of Connective Tissue 12
Connective Tissue Disorders 40
Connective Tissue Disorder 12

External Ids:

Disease Ontology 12 DOID:65
MeSH 41 D003240
NCIt 46 C26729
UMLS 69 C0009782

Summaries for Connective Tissue Disease

MedlinePlus : 40 Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue. Over 200 disorders that impact connective tissue. There are different types: Genetic disorders, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta Autoimmune disorders, such as lupus and scleroderma Cancers, like some types of soft tissue sarcoma Each disorder has its own symptoms and needs different treatment. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Connective Tissue Disease, also known as connective tissue diseases, is related to mixed connective tissue disease and pulmonary hypertension, primary, 1, and has symptoms including joint symptom, musculoskeletal symptom and sciatica. An important gene associated with Connective Tissue Disease is ACTA2 (Actin, Alpha 2, Smooth Muscle, Aorta), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Ethanol and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung, and related phenotypes are cardiovascular system and mortality/aging

Disease Ontology : 12 A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage.

Wikipedia : 72 A connective tissue disease is any disease that has the connective tissues of the body as a target of... more...

Related Diseases for Connective Tissue Disease

Diseases related to Connective Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 412)
# Related Disease Score Top Affiliating Genes
1 mixed connective tissue disease 34.5 ACVRL1 ADAMTS13 BMPR2 CD40LG HLA-DRB1 HSPD1
2 pulmonary hypertension, primary, 1 32.9 ACVRL1 BMPR2
3 marfan syndrome 32.3 ACTA2 FBN1 FBN2
4 aortic aneurysm, familial thoracic 1 32.1 ACTA2 COL3A1 FBN1
5 collagen disease 32.1 APOH CENPB COL3A1 COL5A1 FBN1 PLOD1
6 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.7 HSPD1 IL10 TNFSF13B
7 pneumonia 31.5 CD40LG IL10 IL6 TNF
8 pulmonary hypertension 31.3 ACTA2 ACVRL1 BMPR2 EDNRA IL6
9 arthritis 31.3 HLA-DRB1 IL10 IL6 TNF
10 rheumatoid arthritis 31.2 CD40LG HLA-DRB1 IL10 IL6 TNF TNFSF13B
11 vasculitis 31.2 APOH CD40LG TNF TNFSF13B
12 systemic lupus erythematosus 31.1 ADAMTS13 APOH CD40LG HLA-DRB1 IL10 IL6
13 meningitis 31.1 CD40LG IL10 IL6 TNF
14 purpura 31.0 ADAMTS13 APOH CD40LG TNF
15 spondylitis 30.9 CD40LG IL6 TNF
16 portal hypertension 30.8 BMPR2 EDNRA TNF
17 neuromyelitis optica 30.8 HLA-DRB1 IL6 TNFSF13B
18 spondyloarthropathy 30.8 IL10 IL6 TNF
19 listeriosis 30.7 IL10 IL6 TNF
20 myelitis 30.7 APOH IL6 TNF
21 discoid lupus erythematosus 30.6 APOH HLA-DRB1 IL10
22 antiphospholipid syndrome 30.6 ADAMTS13 APOH CD40LG
23 microscopic polyangiitis 30.6 HLA-DRB1 IL10 TNF
24 myocarditis 30.6 CD40LG IL6 TNF
25 rheumatic disease 30.5 APOH CD40LG CENPB HLA-DRB1 IL10 RNPC3
26 transverse myelitis 30.5 APOH IL10 IL6 TNF
27 bronchiolitis 30.4 CD40LG IL10 IL6 TNF
28 leprosy 3 30.4 CD40LG HSPD1 IL10 TNF
29 helicobacter pylori infection 30.4 HLA-DRB1 IL10 TNF
30 leishmaniasis 30.3 HLA-DRB1 IL10 TNF
31 multiple sclerosis 30.2 HLA-DRB1 HSPD1 IL10 IL6 TNF TNFSF13B
32 autoimmune disease 30.2 APOH CD40LG CENPB HLA-DRB1 HSPD1 IL10
33 aortic aneurysm 30.0 ACTA2 FBN1 IL6
34 undifferentiated connective tissue disease 12.5
35 emilin-1-related connective tissue disease 12.1
36 mass syndrome 11.8
37 bone fragility with contractures, arterial rupture, and deafness 11.7
38 marden-walker syndrome 11.6
39 pulmonary fibrosis 11.1
40 cutis laxa 11.1
41 scleritis 11.1
42 winchester syndrome 11.0
43 crest syndrome 11.0
44 synovitis 11.0
45 lipodermatosclerosis 11.0
46 fibrodysplasia ossificans progressiva 10.9
47 punctate inner choroidopathy 10.8 IL10 TNF
48 nontuberculous mycobacterial lung disease 10.8 FBN1 HLA-DRB1 TNF
49 juvenile myasthenia gravis 10.8 HLA-DRB1 IL10
50 microscopic colitis 10.8 HLA-DRB1 IL6 TNF

Graphical network of the top 20 diseases related to Connective Tissue Disease:



Diseases related to Connective Tissue Disease

Symptoms & Phenotypes for Connective Tissue Disease

UMLS symptoms related to Connective Tissue Disease:


joint symptom, musculoskeletal symptom, sciatica, muscle cramp, back pain

MGI Mouse Phenotypes related to Connective Tissue Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 FBN2 PLOD1 TNF IL10 IL6 CD40LG
2 mortality/aging MP:0010768 10.22 FBN2 PLOD1 HSPD1 TNF IL10 IL6
3 cellular MP:0005384 10.2 FBN1 IL6 FBN2 HSPD1 TNF IL10
4 growth/size/body region MP:0005378 10.18 IL6 FBN2 HSPD1 TNF IL10 FBN1
5 embryo MP:0005380 10.03 FBN1 HSPD1 TNF IL10 BMPR2 EDNRA
6 muscle MP:0005369 10.03 FBN2 PLOD1 HSPD1 TNF IL10 IL6
7 integument MP:0010771 10.02 IL6 PLOD1 TNF IL10 EDNRA CD40LG
8 respiratory system MP:0005388 9.81 IL6 FBN2 TNF IL10 EDNRA FBN1
9 skeleton MP:0005390 9.61 IL6 FBN2 PLOD1 TNF IL10 FBN1
10 vision/eye MP:0005391 9.23 IL6 FBN2 TNF IL10 EDNRA ACTA2

Drugs & Therapeutics for Connective Tissue Disease

Drugs for Connective Tissue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 865)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 2 64-17-5 702
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
3
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
4
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 104987-11-3 445643 439492
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
7
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 50-18-0, 6055-19-2 2907
8
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
9
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
10
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
11
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
12
Sulfasalazine Approved Phase 4,Phase 3,Phase 2 599-79-1 5359476 5353980
13
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 9004-61-9 53477741 24759
14
Atenolol Approved Phase 4,Phase 3,Phase 2 29122-68-7 2249
15
Aminolevulinic acid Approved Phase 4 106-60-5 137
16
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1 446-86-6 2265
17
Goserelin Approved Phase 4,Phase 3 65807-02-5 5311128 47725
18
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
19
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
20
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
21
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Phase 1 378-44-9 9782
22
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
23
Bosentan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147536-97-8 104865
24
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652
25
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
26
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
28
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2 471-34-1
29
Desogestrel Approved Phase 4 54024-22-5 40973
30
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
31
Nandrolone Approved, Experimental, Illicit, Investigational Phase 4 62-90-8, 434-22-0 9904 229455
32
Anastrozole Approved, Investigational Phase 4,Phase 3 120511-73-1 2187
33
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
34
Sulfamethoxazole Approved Phase 4,Phase 2,Phase 3 723-46-6 5329
35
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
36
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 16590-41-3 5360515
37
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
38
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
39
Trimethoprim Approved, Vet_approved Phase 4,Phase 2,Phase 3 738-70-5 5578
40
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
41
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
42
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
43
Menthol Approved Phase 4,Phase 3,Phase 2,Early Phase 1 2216-51-5 16666
44
Lincomycin Approved, Vet_approved Phase 4 154-21-2 656509
45
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
46
Ranibizumab Approved Phase 4,Phase 2,Phase 1 347396-82-1 459903
47
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
48
Dienogest Approved Phase 4 65928-58-7
49
Fluorouracil Approved Phase 4 51-21-8 3385
50
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865

Interventional clinical trials:

(show top 50) (show all 4402)

# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan Unknown status NCT01051960 Phase 4 Ambrisentan
3 the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee Unknown status NCT02524509 Phase 4
4 The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis Unknown status NCT02480335 Phase 4 bosentan
5 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
6 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4 quinipril
7 Superficial Basal Cell Carcinoma Treatment With Topical Photodynamic Therapy With Fractionated 5-aminolevulinic Acid 20% Versus Two Stage Methylaminolevulinate Unknown status NCT01491711 Phase 4 Methylaminolevulinate PDT in 2 sessions;Fractionated 5-aminolevulinic acid hydrochloride 20% gel PDT
8 An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst Unknown status NCT02154789 Phase 4 polidocanol
9 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
10 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
11 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
12 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
13 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
14 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
15 Targeted Ultrasound in Rheumatoid Arthritis Unknown status NCT02056184 Phase 4 Adalimumab
16 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
17 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
18 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
19 Adjunctive Clindamycin for Cellulitis: C4C Trial. Unknown status NCT01876628 Phase 4 Flucloxacillin and Clindamycin;Flucloxacillin and placebo
20 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4
21 Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT01548001 Phase 4 Iguratimod;Methotrexate
22 REstore Working Ability in RheumatoiD Arthritis Unknown status NCT01405326 Phase 4
23 Etanercept and Methotrexate in Patients to Induce Remission in Early Arthritis (EMPIRE) Unknown status NCT01303874 Phase 4 Etanercept (ETN);Placebo
24 Withdrawal of Etanercept After Successful Treatment of Juvenile Idiopathic Arthritis Unknown status NCT01287715 Phase 4 etanercept;etanercept
25 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
26 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Unknown status NCT02440750 Phase 4 Dienogest;Ulipristal acetate
27 Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) Unknown status NCT01067430 Phase 4 Etoricoxib;Diclofenac
28 Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis Unknown status NCT01000441 Phase 4 infliximab, etanercept, adalimumab;abatacept, rituximab or tocilizumab
29 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
30 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
31 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4 Dienogest;Goserelin;Desogestrel
32 Bucillamine Study of Holding Remission After Infliximab Dose-off Unknown status NCT00716248 Phase 4 bucillamine;methotrexate
33 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4
34 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
35 Rheumatoid Arthritis Patients in Training Unknown status NCT00434200 Phase 4
36 Hanyang University Medical Center Arthritis Network Unknown status NCT00418405 Phase 4
37 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
38 Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis Unknown status NCT00291915 Phase 4 Adalimumab;Methotrexate
39 Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis Unknown status NCT00216177 Phase 4 Infliximab;Adalimumab
40 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
41 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
42 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
43 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
44 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
45 Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome Unknown status NCT02370550 Phase 4 Cyclosporin A;Prednisone;Placebo;Calcium carbonate D
46 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4 Anakinra;TNF alpha inhibitors
47 Retinal Ganglion Cell Function After Intravitreous Ranibizumab in Patients With Diabetic Macular Edema Unknown status NCT02055911 Phase 4 Ranibizumab
48 Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate Unknown status NCT01270035 Phase 4 Adalimumab
49 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
50 Influenza Vaccination in Patients With Scleroderma Unknown status NCT01002508 Phase 4

Search NIH Clinical Center for Connective Tissue Disease

Cochrane evidence based reviews: connective tissue diseases

Genetic Tests for Connective Tissue Disease

Genetic tests related to Connective Tissue Disease:

# Genetic test Affiliating Genes
1 Abnormality of Connective Tissue 28

Anatomical Context for Connective Tissue Disease

MalaCards organs/tissues related to Connective Tissue Disease:

38
Skin, Bone, Lung, Eye, Heart, Testes, Endothelial

Publications for Connective Tissue Disease

Articles related to Connective Tissue Disease:

(show top 50) (show all 1124)
# Title Authors Year
1
Advocating for early interstitial lung disease detection in mixed connective tissue disease. ( 28977485 )
2018
2
Screening for connective tissue disease-associated antibodies by automated immunoassay. ( 29306915 )
2018
3
Progression and mortality of interstitial lung disease in mixed connective tissue disease: a long-term observational nationwide cohort study. ( 28379478 )
2018
4
Podocyte Infolding Glomerulopathy (PIG) in a Patient With Undifferentiated Connective Tissue Disease: A CaseA Report. ( 29395482 )
2018
5
Connective tissue diseases: T cells in blood mark SjAPgren syndrome activity. ( 29416139 )
2018
6
Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality. ( 29320807 )
2018
7
Cyclophosphamide for connective tissue disease-associated interstitial lung disease. ( 29297205 )
2018
8
CT Features of the Usual Interstitial Pneumonia Pattern: Differentiating Connective Tissue Disease-Associated Interstitial Lung Disease From Idiopathic Pulmonary Fibrosis. ( 29140119 )
2018
9
Association of Autoimmune Connective Tissue Disease With Abdominoplasty Outcomes: A Nationwide Analysis of Outcomes. ( 29094151 )
2018
10
Pulmonary Hypertension Complicating Connective Tissue Disease. ( 29032565 )
2017
11
Impact of connective tissue disease on the surgical outcomes of aortic dissection in patients with cystic medial necrosis. ( 29169363 )
2017
12
Undifferentiated connective tissue disease: predictors of evolution into definite disease. ( 28770704 )
2017
13
Pathologic Separation of Chronic Hypersensitivity Pneumonitis From Fibrotic Connective Tissue Disease-associated Interstitial Lung Disease. ( 28614213 )
2017
14
Replacing a phosphodiesterase-5 inhibitor with riociguat in patients with connective tissue disease-associated pulmonary arterial hypertension: a case series. ( 28671485 )
2017
15
Autoantibody to scaffold attachment factor B (SAFB): A novel connective tissue disease-related autoantibody associated with interstitial lung disease. ( 27682649 )
2017
16
Connective tissue disease: Reflections on the EULAR recommendations for the treatment of systemic sclerosis. ( 28053333 )
2017
17
Successful treatment of Type B insulin resistance with mixed connective tissue disease by pulse glucocorticoids and cyclophosphamide. ( 28084020 )
2017
18
Parvovirus B19 infection in an adult presenting with connective tissue disease-like symptoms: a report of the clinical and histological findings. ( 28633740 )
2017
19
Radiologic pleuroparenchymal fibroelastosis-like lesion in connective tissue disease-related interstitial lung disease. ( 28666014 )
2017
20
Selexipag for the treatment of connective tissue disease-associated pulmonary arterial hypertension. ( 28818881 )
2017
21
Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study. ( 29268795 )
2017
22
Treatment of Vasodilator-resistant Mixed Connective Tissue Disease-associated Pulmonary Arterial Hypertension with Glucocorticoid and Cyclophosphamide. ( 28202869 )
2017
23
Intracranial lesion as onset symptom in a patient with early undifferentiated connective tissue disease: a case report. ( 28476103 )
2017
24
Pulmonary fibrosis in connective tissue disease (CTD): urgent challenges and opportunities. ( 28899080 )
2017
25
Rituximab versus cyclophosphamide for the treatment of connective tissue disease-associated interstitial lung disease (RECITAL): study protocol for a randomised controlled trial. ( 28619061 )
2017
26
Retinal Vasculitis and Choroidopathy in Pediatric-Onset Mixed Connective Tissue Disease. ( 28937479 )
2017
27
Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist's point of view. ( 28704913 )
2017
28
Undifferentiated connective tissue disease, fibromyalgia and the environmental factors. ( 28368979 )
2017
29
Facts and controversies in mixed connective tissue disease. ( 28864092 )
2017
30
The risk of autoimmune connective tissue diseases in patients with atopy: A nationwide population-based cohort study. ( 28814359 )
2017
31
Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis (otherwise referred to as very early-early systemic sclerosis): a TDI study. ( 28993902 )
2017
32
Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review. ( 28923086 )
2017
33
Major depression: An under reported neuropsychiatric manifestation of Mixed Connective Tissue Disease. ( 28753451 )
2017
34
Serum KL-6 and surfactant protein-D as monitoring and predictive markers of interstitial lung disease in patients with systemic sclerosis and mixed connective tissue disease. ( 28275485 )
2017
35
Open Thoracic and Thoraco-abdominal Aortic Repair in Patients with Connective Tissue Disease. ( 28916127 )
2017
36
Review of Primary Cutaneous Mucinoses in Nonlupus Connective Tissue Diseases. ( 28673091 )
2017
37
Primary anetoderma with undifferentiated connective tissue disease. ( 29447658 )
2017
38
Emergence of Smoldering ANCA-associated Glomerulonephritis During the Clinical Course of Mixed Connective Tissue Disease and SjAPgren's Syndrome. ( 29269683 )
2017
39
An unusual association between hemophagocytic lymphohistiocytosis, mixed connective tissue disease, and autoimmune hemolytic anemia: A case report. ( 28700492 )
2017
40
Mixed Connective Tissue Disease and Epitope Spreading: An Historical Cohort Study. ( 28248800 )
2017
41
Tadalafil in idiopathic or heritable pulmonary arterial hypertension (PAH) compared to PAH associated with connective tissue disease. ( 28279499 )
2017
42
Predictors of Favorable Responses to Immunosuppressive Treatment in Pulmonary Arterial Hypertension Associated With Connective Tissue Disease. ( 28904255 )
2017
43
Pulmonary-Limited Granulomatosis with Polyangiitis Coexisting with Mixed Connective Tissue Disease. ( 28592713 )
2017
44
Scleroderma Renal Crisis in Mixed Connective Tissue Disease With Full Renal Recovery Within 3 Months: A Case Report With Expanding Treatment Modalities to Treat Each Clinical Sign as an Independent Entity. ( 29051891 )
2017
45
Are the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and the undifferentiated connective tissue disease (UCTD) related to each other? A case-control study of environmental exposures. ( 28332072 )
2017
46
Lack of Response to Intravenous Sodium Thiosulfate in Three Cases of Extensive Connective Tissue Disease-Associated Calcinosis Cutis. ( 28667747 )
2017
47
Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease. ( 28053878 )
2017
48
Four Cases of Pneumatosis Cystoides Intestinalis Complicated by Connective Tissue Diseases. ( 28458320 )
2017
49
Protein-losing Gastroenteropathy Related to Mixed Connective Tissue Disease: A Case Report of a Successful Outcome and Literature Review. ( 28768981 )
2017
50
Marfan syndrome; A connective tissue disease at the crossroads of mechanotransduction, TGFI^ signaling and cell stemness. ( 28782645 )
2017

Variations for Connective Tissue Disease

ClinVar genetic disease variations for Connective Tissue Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ACTA2 NM_001613.2(ACTA2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs387906592 GRCh37 Chromosome 10, 90701066: 90701066

Expression for Connective Tissue Disease

Search GEO for disease gene expression data for Connective Tissue Disease.

Pathways for Connective Tissue Disease

Pathways related to Connective Tissue Disease according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 ACTA2 ACVRL1 BMPR2 CD40LG COL3A1 COL5A1
2
Show member pathways
13.28 ACTA2 ACVRL1 BMPR2 CD40LG IL10 IL6
3
Show member pathways
13.16 ACTA2 ACVRL1 BMPR2 CD40LG IL10 IL6
4
Show member pathways
12.97 ACTA2 COL3A1 COL5A1 FBN1 FBN2 IL6
5
Show member pathways
12.64 COL3A1 COL5A1 FBN1 FBN2 PLOD1
6
Show member pathways
12.5 CD40LG COL5A1 HLA-DRB1 HSPD1 IL10 IL6
7
Show member pathways
12.35 CD40LG IL10 IL6 TNF
8
Show member pathways
12.15 CD40LG HLA-DRB1 IL10 TNF
9
Show member pathways
12.12 ACTA2 COL3A1 COL5A1 FBN1 FBN2
10 12.07 HSPD1 IL10 IL6 TNF
11 12.05 HLA-DRB1 HSPD1 IL10 IL6 TNF
12 11.76 COL3A1 IL10 IL6 TNF
13
Show member pathways
11.72 CD40LG TNF TNFSF13B
14 11.71 HLA-DRB1 IL6 TNF TNFSF13B
15 11.67 IL10 IL6 TNF
16 11.66 IL10 IL6 TNF
17
Show member pathways
11.64 CD40LG TNF TNFSF13B
18
Show member pathways
11.56 CD40LG IL6 TNF
19 11.48 HSPD1 IL6 TNF
20 11.41 IL10 IL6 TNF
21 11.36 CD40LG IL10 IL6 TNF
22 11.24 IL10 IL6 TNF
23 11.23 IL10 IL6 TNF
24 11.17 CD40LG IL10 IL6 TNF TNFSF13B
25 11.06 CD40LG IL10 IL6 TNF TNFSF13B
26 11.03 HLA-DRB1 IL10 IL6 TNF
27 10.18 CD40LG COL3A1 COL5A1 FBN1 FBN2 IL10

GO Terms for Connective Tissue Disease

Cellular components related to Connective Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.77 ADAMTS13 COL3A1 COL5A1 FBN1 FBN2
2 endoplasmic reticulum lumen GO:0005788 9.72 ADAMTS13 COL3A1 COL5A1 FBN1 IL6
3 extracellular matrix GO:0031012 9.63 APOH COL3A1 COL5A1 FBN1 FBN2 HSPD1
4 cell surface GO:0009986 9.56 ACVRL1 ADAMTS13 APOH BMPR2 CD40LG HLA-DRB1
5 extracellular space GO:0005615 9.44 ACTA2 ADAMTS13 APOH BMPR2 CD40LG COL3A1
6 microfibril GO:0001527 9.4 FBN1 FBN2
7 extracellular region GO:0005576 10 ADAMTS13 APOH CD40LG COL3A1 COL5A1 FBN1

Biological processes related to Connective Tissue Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 T cell costimulation GO:0031295 9.8 CD40LG HLA-DRB1 TNFSF13B
2 positive regulation of endothelial cell proliferation GO:0001938 9.78 ACVRL1 BMPR2 IL10
3 response to glucocorticoid GO:0051384 9.77 IL10 IL6 TNF
4 positive regulation of T cell proliferation GO:0042102 9.76 CD40LG IL6 TNFSF13B
5 cellular response to lipopolysaccharide GO:0071222 9.76 ADAMTS13 IL10 IL6 TNF
6 positive regulation of osteoblast differentiation GO:0045669 9.75 BMPR2 FBN2 IL6
7 immune response GO:0006955 9.73 CD40LG HLA-DRB1 IL10 IL6 TNF TNFSF13B
8 positive regulation of interleukin-6 production GO:0032755 9.72 HSPD1 IL6 TNF
9 negative regulation of DNA biosynthetic process GO:2000279 9.65 ACVRL1 BMPR2
10 supramolecular fiber organization GO:0097435 9.65 COL3A1 COL5A1
11 negative regulation of endothelial cell proliferation GO:0001937 9.65 ACVRL1 APOH TNF
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 IL10 TNF
13 lymphangiogenesis GO:0001946 9.64 ACVRL1 BMPR2
14 embryonic eye morphogenesis GO:0048048 9.63 FBN1 FBN2
15 regulation of receptor activity GO:0010469 9.63 CD40LG FBN1 IL10 IL6 TNF TNFSF13B
16 retina vasculature development in camera-type eye GO:0061298 9.62 ACVRL1 BMPR2
17 negative regulation of lipid storage GO:0010888 9.62 IL6 TNF
18 platelet activation GO:0030168 9.62 ADAMTS13 CD40LG COL3A1 IL6
19 wound healing, spreading of epidermal cells GO:0035313 9.61 ACVRL1 COL5A1
20 artery development GO:0060840 9.59 ACVRL1 BMPR2
21 lymphatic endothelial cell differentiation GO:0060836 9.57 ACVRL1 BMPR2
22 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 IL10 TNF
23 regulation of immunoglobulin secretion GO:0051023 9.54 CD40LG TNF
24 B cell proliferation GO:0042100 9.54 CD40LG HSPD1 IL10
25 venous blood vessel development GO:0060841 9.52 ACVRL1 BMPR2
26 regulation of cellular response to growth factor stimulus GO:0090287 9.51 FBN1 FBN2
27 immunoglobulin secretion GO:0048305 9.49 CD40LG TNFSF13B
28 receptor biosynthetic process GO:0032800 9.43 IL10 TNF
29 sequestering of TGFbeta in extracellular matrix GO:0035583 9.4 FBN1 FBN2
30 extracellular matrix organization GO:0030198 9.35 COL3A1 COL5A1 FBN1 FBN2 TNF
31 endothelial cell apoptotic process GO:0072577 8.8 BMPR2 IL10 TNF

Molecular functions related to Connective Tissue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.46 ADAMTS13 COL3A1 COL5A1 FBN1
2 platelet-derived growth factor binding GO:0048407 9.43 COL3A1 COL5A1
3 tumor necrosis factor receptor binding GO:0005164 9.43 CD40LG TNF TNFSF13B
4 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.4 ACVRL1 BMPR2
5 BMP receptor activity GO:0098821 9.37 ACVRL1 BMPR2
6 cytokine activity GO:0005125 9.35 CD40LG IL10 IL6 TNF TNFSF13B
7 extracellular matrix constituent conferring elasticity GO:0030023 9.32 FBN1 FBN2
8 extracellular matrix structural constituent GO:0005201 8.92 COL3A1 COL5A1 FBN1 FBN2

Sources for Connective Tissue Disease

3 CDC