MCID: CNN005
MIFTS: 51

Connective Tissue Disease malady

Summaries for Connective Tissue Disease

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Connective tissue is the material inside your body that supports many of its parts. it is the "cellular glue" that gives your tissues their shape and helps keep them strong. it also helps some of your tissues do their work. cartilage and fat are examples of connective tissue. there are over 200 disorders that impact connective tissue. some, like cellulitis, are the result of an infection. injuries can cause connective tissue disorders, such as scars. others, such as ehlers-danlos syndrome, marfan syndrome, and osteogenesis imperfecta, are genetic. still others, like scleroderma, have no known cause. each disorder has its own symptoms and needs different treatment.

MalaCards: Connective Tissue Disease, also known as connective tissue diseases, is related to mixed connective tissue disease and systemic lupus erythematosus. An important gene associated with Connective Tissue Disease is POP1 (processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)), and among its related pathways is mRNA Splicing - Major Pathway. The compounds serine and atp have been mentioned in the context of this disorder. Related mouse phenotype mortality/aging.

Disease Ontology:8 A tissue disease that affects tissues such as skin, tendons, and cartilage.

Wikipedia:64 A connective tissue disease is any disease that has the connective tissues of the body as a target of... more...

Aliases & Classifications for Connective Tissue Disease

Sources:
8Disease Ontology, 64Wikipedia, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 35MeSH, 40NCIt, 57SNOMED-CT
See all sources

Aliases & Descriptions:

connective tissue disease 8 64 10
connective tissue diseases 45 61
disorder of connective tissue 8
other musculoskelet/connectiv 8
connective tissue disorders 34
connective tissue disorder 8
connective tissue dis. 8


External Ids:

Disease Ontology8 DOID:65
MeSH35 D003240
NCIt40 C26729

Related Diseases for Connective Tissue Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Connective Tissue Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 296)
idRelated DiseaseScoreTop Affiliating Genes
1mixed connective tissue disease32.1LSM2, S100A9, APOH, BMPR2, SNRNP70, SNRPA
2systemic lupus erythematosus31.2HSPG2, HSPD1, LSM2, S100A9, APOH, SNRNP70
3arthritis31.1HSPD1, S100A9, FBN1, PRTN3
4vasculitis30.9HSPD1, S100A9, APOH, PRTN3
5hepatitis c30.8HSPG2, HSPD1, FBL, PRTN3, RNPC3
6vascular disease30.7HSPD1, APOH, BMPR2, PRTN3, ACVRL1
7rheumatic disease30.7LSM2, APOH, RNPC3, CENPB
8polymyositis30.7HSPG2, S100A9, FBL, RNPC3
9systemic scleroderma30.7CENPB, SNRNP70
10primary biliary cirrhosis30.5CENPB, RNPC3, PRTN3, HSPD1, HSPG2
11ankylosing spondylitis30.5HSPD1, FBN1, PRTN3
12nephritis30.5APOH, PRTN3, RNPC3
13lupus nephritis30.5ADAMTS13, APOH
14atherosclerosis30.2HSPG2, HSPD1, S100A9, APOH, FBN1, PRTN3
15primary pulmonary hypertension30.2ACVRL1, FBN1, BMPR2
16antiphospholipid syndrome30.2HSPG2, APOH, ADAMTS13
17pemphigus30.2DSG1
18aortic aneurysm30.0FBN1
19polyarteritis nodosa30.0PRTN3
20conn's syndrome10.9
21raynaud disease10.7
22hepatitis d10.6
23n syndrome10.5
24hepatitis a10.5
25congenital heart block10.5
26thrombotic thrombocytopenic purpura10.5
27vascular tissue disease10.5
28autoimmune hepatitis10.5
29cardiac tamponade10.4
30aseptic meningitis10.4
31thyroiditis10.4
32protein-losing enteropathy10.4
33osteoporosis10.4
34spondylitis10.4
35pulmonary function10.4
36lip disease10.4
37undifferentiated connective tissue syndrome10.4
38leri pleonosteosis10.3
39aneurysm disease10.3
40thrombocytopenia10.3
41sharp syndrome10.3
42cutis laxa10.3
43congenital contractural arachnodactyly10.3
44myelitis10.3
45neuromyelitis optica10.3
46idiopathic pulmonary fibrosis10.3
47portal hypertension10.3
48pneumatosis cystoides intestinalis10.3
49amyloidosis10.3
50arthropathy10.3

Graphical network of the top 20 diseases related to Connective Tissue Disease:



Diseases related to connective tissue disease

Clinical Features for Connective Tissue Disease

Drugs & Therapeutics for Connective Tissue Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Connective Tissue Disease

Drug clinical trials:

Search ClinicalTrials for Connective Tissue Disease

Search NIH Clinical Center for Connective Tissue Disease

Search CenterWatch for Connective Tissue Disease

Genetic Tests for Connective Tissue Disease

Anatomical Context for Connective Tissue Disease

Animal Models for Connective Tissue Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Connective Tissue Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.0ADAMTS13, HSPD1, S100A9, APOH, BMPR2, FBN1

Publications for Connective Tissue Disease

Sources:
51PubMed
See all sources

Articles related to Connective Tissue Disease:

(show top 50)    (show all 963)
idTitleAuthorsYear
1
Connective tissue disease in pregnancy. (24298106)
2013
2
Sustained remission of antineutrophil cytoplasmic antibody-mediated glomerulonephritis and nephrotic syndrome in mixed connective tissue disease. (23864923)
2013
3
Immunogenicity of influenza H1N1 vaccination in mixed connective tissue disease: effect of disease and therapy. (23525305)
2013
4
Significance of connective tissue diseases features in pulmonary fibrosis. (23997055)
2013
5
The influence of connective tissue disease in the management of lower limb ischemia. (24184498)
2013
6
Intrapleural corticosteroid injection in eosinophilic pleural effusion associated with undifferentiated connective tissue disease. (24265645)
2013
7
Assessment of the 'no eosinophils' rule: are eosinophils truly absent in pityriasis lichenoides, connective tissue disease, and graft-vs.-host disease? (22443393)
2012
8
Neuropsychological assessment in mixed connective tissue disease: comparison with systemic lupus erythematosus. (22433916)
2012
9
A patient with spotted fever group rickettsiosis mimicking connective tissue disease. (23086032)
2012
10
Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study. (22550317)
2012
11
Connective tissue diseases: Immune responses in Mikulicz disease differ from those in SS. (21971284)
2011
12
Chest abnormalities in juvenile-onset mixed connective tissue disease: assessment with high-resolution computed tomography and pulmonary function tests. (19277918)
2009
13
Avascular necrosis of femoral head associated with connective tissue disease in Nigerians: case series. (20425744)
2009
14
Sarcoidosis in patients with mixed connective tissue disease: clinical, genetic, serological and histological observations. (18196245)
2008
15
Therapeutic vignette: old and new drugs in mixed connective tissue disease. (19070300)
2008
16
A case report of successful treatment with immunoadsorption onto protein A in mixed connective tissue disease in childhood. (18789123)
2008
17
Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease. (18668536)
2008
18
Mixed connective tissue disease: a case with scleroderma renal crisis following abortion. (17119864)
2007
19
When to stop in the quest of formes frustes of connective tissue disease? (17235651)
2007
20
Semiquantitative assessment of the intestinal motility in chronic intestinal pseudo-obstruction in systemic sclerosis and mixed connective tissue disease by Sitzmarks capsule. (17039319)
2006
21
The prognostic value of nailfold capillary changes for the development of connective tissue disease in children and adolescents with primary raynaud phenomenon: a follow-up study of 250 patients. (17014637)
2006
22
Surgical treatment for atlantoaxial subluxation associated with mixed connective tissue disease. (16628999)
2006
23
The role of endothelin-1 and selected cytokines in the pathogenesis of Raynaud's phenomenon associated with systemic connective tissue diseases. (16763543)
2006
24
Marked pneumatosis cystoides intestinalis in a patient with mixed connective tissue disease. (16881129)
2006
25
Serum levels of manganese superoxide dismutase in patients with mixed connective tissue disease. (16095129)
2005
26
Raynaud's phenomenon in undifferentiated connective tissue disease (UCTD). (15351873)
2005
27
Pediatric-onset mixed connective tissue disease. (16084320)
2005
28
Undifferentiated connective tissue disease with various pigmentary patterns: a study of three patients. (15552610)
2004
29
The impact of coexisting connective tissue disease on survival in patients with fibrosing alveolitis. (12048295)
2002
30
A nationwide followup study of autoimmune and connective tissue disease among hip and knee implant patients. (12627787)
2002
31
Unclassified or undifferentiated connective tissue disease. (10882218)
2000
32
Severe mixed connective tissue disease in a woman with pure gonadal dysgenesis: estrogens do not influence disease expression. (10229418)
1999
33
Soluble intercellular adhesion molecule-1 in paediatric connective tissue diseases. (10342537)
1999
34
Mixed connective tissue disease presenting to the acute hand service. (9678475)
1998
35
Focal myositis presenting as pseudothrombophlebitis of the neck in a patient with mixed connective tissue disease. (8670340)
1996
36
Changes in the gastrointestinal system of children with inflammatory systemic connective tissue diseases]. (8657492)
1995
37
Analysis of anti-U1 RNA antibodies in patients with connective tissue disease. Association with HLA and clinical manifestations of disease. (8849357)
1995
38
Enhanced synthesis of cytokines by peripheral blood monocytes cultured in the presence of autoantibodies against U1-ribonucleoprotein and/or negatively charged molecules: implication in the pathogenesis of pulmonary hypertension in mixed connective tissue disease (MCTD). (7994907)
1994
39
A kindred exhibiting cosegregation of an overlap connective tissue disorder and the chromosome 16 linked form of autosomal dominant polycystic kidney disease. (8130364)
1993
40
Anticardiolipin antibodies are associated with pulmonary hypertension in patients with mixed connective tissue disease or systemic lupus erythematosus. (8481653)
1993
41
The dysfunction of peripheral blood dendritic cells in patients with mixed connective tissue disease. (8347095)
1993
42
Antibodies to casein kinase II in sera of patients with mixed connective tissue disease: evaluation with recombinant proteins. (8252720)
1993
43
Amyloidosis in mixed connective tissue disease. (2772564)
1989
44
Acute scleroderma in stable mixed connective tissue disease: treatment by plasmapheresis. (3675385)
1987
45
Nuclear ribonucleoprotein immune complexes in pericardial fluid of a patient with mixed connective tissue disease. (3814202)
1987
46
Disseminated nocardiosis in a patient with mixed connective tissue disease. (4095403)
1985
47
Orogenital ulcerations in mixed connective tissue disease. (4045874)
1985
48
Renal involvement in mixed connective tissue disease. Report of 5 cases. (2931986)
1985
49
Thrombotic thrombocytopenic purpura occurring in a patient with mixed connective tissue disease. (6540471)
1984
50
Cardiac involvement in mixed connective tissue disease. Pathomorphologic changes. (6831968)
1983

Genetic Variations for Connective Tissue Disease

Expression for genes affiliated with Connective Tissue Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Connective Tissue Disease

Search GEO for disease gene expression data for Connective Tissue Disease.

Pathways for genes affiliated with Connective Tissue Disease

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Connective Tissue Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6SNRPA, SNRPC, SNRNP70, LSM2

Compounds for genes affiliated with Connective Tissue Disease

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Connective Tissue Disease according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1serine4511.2ADAMTS13, LSM2, BMPR2, SNRNP70, FBN1, FBL
2atp45 2912.1HSPG2, HSPD1, LSM2, S100A9, APOH, SNRPA
3arginine4511.0LSM2, APOH, BMPR2, FBN1, FBL, RNPC3
4calcium45 50 11 2414.0HSPG2, HSPD1, S100A9, APOH, FBN1, PRTN3
5gold4511.0HSPD1, APOH, MFAP2, FBN1, PRTN3
6tyrosine4510.9HSPG2, HSPD1, S100A9, MFAP2, BMPR2, FBN1
7rituximab45 50 1112.9APOH, PRTN3, DSG1, ADAMTS13
8zinc45 2411.9LSM2, S100A9, APOH, SNRPC, RNPC3, ADAMTS13
9endotoxin4510.9HSPD1, S100A9, APOH, ADAMTS13
10phosphatidylserine45 29 1112.9HSPG2, APOH, PRTN3, RNPC3
11rrna4510.8RNPC3, FBL, HSPD1
12oxygen45 2411.7HSPD1, S100A9, APOH, BMPR2, FBN1, PRTN3
13neomycin4510.7HSPG2, HSPD1, RNPC3
14retinoic acid45 2411.6HSPG2, HSPD1, S100A9, FBN1, PRTN3, DSG1
15propylthiouracil45 2 1112.5APOH
16fibrinogen4510.4ADAMTS13, APOH, S100A9, HSPD1

GO Terms for genes affiliated with Connective Tissue Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Connective Tissue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00998610.7ADAMTS13, ACVRL1, BMPR2, APOH, HSPD1
2microfibrilGO:00152710.6FBN1, MFAP2
3extracellular matrixGO:03101210.6HSPG2, APOH, FBN1, PRTN3
4extracellular spaceGO:00561510.5HSPG2, HSPD1, S100A9, APOH, FBN1, ADAMTS13

Biological processes related to Connective Tissue Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1mRNA splicing, via spliceosomeGO:00039810.8SNRPA, SNRPC, SNRNP70, LSM2
2venous blood vessel developmentGO:06084110.8ACVRL1, BMPR2
3lymphatic endothelial cell differentiationGO:06083610.7BMPR2, ACVRL1
4negative regulation of DNA biosynthetic processGO:200027910.7ACVRL1, BMPR2
5retina vasculature development in camera-type eyeGO:06129810.6BMPR2, ACVRL1
6negative regulation of endothelial cell migrationGO:01059610.6ACVRL1, APOH
7artery developmentGO:06084010.6BMPR2, ACVRL1
8RNA splicingGO:00838010.5LSM2, SNRNP70, SNRPA, RNPC3
9lymphangiogenesisGO:00194610.3ACVRL1, BMPR2

Molecular functions related to Connective Tissue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.8ADAMTS13, HSPG2, HSPD1, LSM2, S100A9, APOH
2transforming growth factor beta-activated receptor activityGO:00502410.6ACVRL1, BMPR2

Products for genes affiliated with Connective Tissue Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Connective Tissue Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet