Aliases & Classifications for Connective Tissue Disease

MalaCards integrated aliases for Connective Tissue Disease:

Name: Connective Tissue Disease 12 14
Connective Tissue Diseases 52 42 69
Abnormality of Connective Tissue 29
Disorder of Connective Tissue 12
Connective Tissue Disorders 41
Connective Tissue Disorder 12

External Ids:

Disease Ontology 12 DOID:65
MeSH 42 D003240
NCIt 47 C26729
UMLS 69 C0009782

Summaries for Connective Tissue Disease

MedlinePlus : 41 your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. it is like a "cellular glue" that gives your body parts their shape and helps keep them strong. it also helps some of your tissues do their work. it is made of many kinds of proteins. cartilage and fat are types of connective tissue. over 200 disorders that impact connective tissue. there are different types: genetic disorders, such as ehlers-danlos syndrome, marfan syndrome, and osteogenesis imperfecta autoimmune disorders, such as lupus and scleroderma cancers, like some types of soft tissue sarcoma each disorder has its own symptoms and needs different treatment. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary : Connective Tissue Disease, also known as connective tissue diseases, is related to rheumatoid arthritis and primary biliary cirrhosis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Connective Tissue Disease is ACTA2 (Actin, Alpha 2, Smooth Muscle, Aorta), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Simvastatin and Bosentan have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung, and related phenotypes are cardiovascular system and cellular

Disease Ontology : 12 A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage.

Wikipedia : 72 A connective tissue disease is any disease that has the connective tissues of the body as a target of... more...

Related Diseases for Connective Tissue Disease

Diseases related to Connective Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 438)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 31.5 CD40LG HLA-DRB1 IFNG IL10 IL6 TNF
2 primary biliary cirrhosis 31.5 IL10 IL6 TNF
3 calcinosis 31.4 CD40LG IL6 TNF
4 atherosclerosis 31.2 HLA-DRB1 IFNG IL10 IL6 TNF
5 systemic lupus erythematosus 31.2 ADAMTS13 APOH CD40LG HLA-DRB1 IFNG IL10
6 myelitis 31.2 IFNG IL10 IL6
7 choroiditis 30.9 IL10 IL6 TNF
8 hemophagocytic lymphohistiocytosis 30.9 IFNG IL10 IL6 TNF
9 lymphoma 30.8 APOH CD40LG IFNG IL10 IL6 TNF
10 reticulosarcoma 30.7 IFNG IL6 TNF
11 mixed connective tissue disease 12.5
12 undifferentiated connective tissue disease 12.4
13 emilin-1-related connective tissue disease 12.0
14 lysyl hydroxylase 3 deficiency 11.6
15 mass syndrome 11.6
16 marden-walker syndrome 11.5
17 pure autonomic failure 11.2 IL10 TNF
18 not otherwise specified 3-mga-uria type 11.2 FBN1 HLA-DRB1 TNF
19 epstein-barr virus hepatitis 11.2 HLA-DRB1 IL6 TNF
20 anencephaly and spina bifida x-linked 11.2 HLA-DRB1 IL6 TNF
21 mosaic trisomy 1 11.2 HLA-DRB1 IFNG TNF
22 ethmoid sinus adenocarcinoma 11.2 IL10 IL6 TNF
23 reproductive system disease 11.2 CD40LG HLA-DRB1 IL10
24 balkan hemorrhagic fever 11.2 CD40LG IL10
25 indolent myeloma 11.2 CD40LG IL6 TNF
26 acute ackee fruit intoxication 11.2 IL10 TNF
27 alkhurma hemorrhagic fever 11.2 CD40LG IL10 TNF
28 smarca4-deficient sarcoma of thorax 11.2 IL6 TNF
29 dumping syndrome 11.2 CD40LG IFNG IL10
30 hypogonadotropism 11.2 CD40LG IL6 TNF
31 phlyctenulosis 11.2 IL10 IL6 TNF
32 plantar wart 11.2 IFNG IL10 TNF
33 oropharyngeal cancer, childhood 11.1 IFNG IL10 TNF
34 megaloblastic anemia 11.1 CD40LG IL10 TNF
35 centronuclear myopathy 5 11.1 CD40LG IFNG IL10
36 papillary squamous carcinoma 11.1 HLA-DRB1 IFNG IL10
37 ulcerative colitis 11.1 IL10 IL6 TNF
38 moderately severe hemophilia b 11.1 HLA-DRB1 IL10 TNF
39 hematocele of tunica vaginalis testis 11.1 ACVRL1 BMPR2 TNF
40 chlamydia 11.1 CD40LG HSPD1 IFNG
41 physical urticaria 11.1 CD40LG CENPB FBN1
42 foodborne botulism 11.1 CD40LG IL6 TNF
43 endogenous depression 11.1 CD40LG HLA-DRB1 TNF
44 pasteurellosis 11.1 IFNG IL6 TNF
45 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 11.1 IFNG IL10 TNFSF13B
46 spindle cell hemangioma 11.1 IFNG IL10 TNF
47 glioblastoma multiforme 11.1 CD40LG IL10 TNF
48 ovarian mucinous adenofibroma 11.1 IL10 IL6 TNF
49 noma 11.1 IL10 IL6 TNF
50 human monocytic ehrlichiosis 11.1 CD40LG IL6 TNF

Graphical network of the top 20 diseases related to Connective Tissue Disease:



Diseases related to Connective Tissue Disease

Symptoms & Phenotypes for Connective Tissue Disease

UMLS symptoms related to Connective Tissue Disease:


back pain, muscle cramp, sciatica, musculoskeletal symptom, joint symptom

MGI Mouse Phenotypes related to Connective Tissue Disease:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 ACTA2 ACVRL1 BMPR2 CD40LG COL3A1 COL5A1
2 cellular MP:0005384 10.24 BMPR2 CD40LG CENPB COL3A1 EDNRA FBN1
3 growth/size/body region MP:0005378 10.23 ACVRL1 BMPR2 CENPB COL3A1 COL5A1 EDNRA
4 mortality/aging MP:0010768 10.22 IL6 PLOD1 TNF ACVRL1 ADAMTS13 APOH
5 hematopoietic system MP:0005397 10.17 ACVRL1 ADAMTS13 BMPR2 CD40LG EDNRA FBN1
6 immune system MP:0005387 10.14 FBN1 IFNG IL10 IL6 TNF TNFSF13B
7 embryo MP:0005380 10.13 ACVRL1 BMPR2 COL5A1 EDNRA FBN1 HSPD1
8 integument MP:0010771 10.07 CD40LG COL3A1 COL5A1 EDNRA FBN1 IFNG
9 muscle MP:0005369 10.03 PLOD1 TNF ACTA2 ACVRL1 BMPR2 COL3A1
10 respiratory system MP:0005388 9.81 ACVRL1 BMPR2 COL3A1 EDNRA FBN1 IFNG
11 skeleton MP:0005390 9.61 BMPR2 CD40LG EDNRA FBN1 IFNG IL10
12 vision/eye MP:0005391 9.23 EDNRA IFNG IL10 IL6 TNF ACTA2

Drugs & Therapeutics for Connective Tissue Disease

Drugs for Connective Tissue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 859)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4,Phase 3,Phase 1 79902-63-9 54454
2
Bosentan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147536-97-8 104865
3
Aminolevulinic acid Approved Phase 4 106-60-5 137
4
Polidocanol Approved Phase 4 9002-92-0
5
Fluorouracil Approved Phase 4 51-21-8 3385
6
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
7
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
8
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
9
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
10
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652
11
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
13
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 16590-41-3 5360515
14
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
15
Sulfasalazine Approved Phase 4,Phase 3,Phase 2 599-79-1 5353980 5359476
16
Menthol Approved Phase 4,Phase 3,Phase 2,Early Phase 1 2216-51-5 16666
17
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
18
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
19
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
20
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
21
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
22
Desogestrel Approved Phase 4 54024-22-5 40973
23
Dienogest Approved Phase 4 65928-58-7
24
Goserelin Approved Phase 4,Phase 3 65807-02-5 47725 5311128
25
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
26
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
27
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
28
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
29
Calcium Carbonate Approved Phase 4,Phase 3,Phase 2 471-34-1
30
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 50-18-0, 6055-19-2 2907
31
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
32
Ranibizumab Approved Phase 4,Phase 1,Phase 2 347396-82-1 459903
33
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1 446-86-6 2265
34
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
35
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
36
Ethanol Approved Phase 4,Phase 2 64-17-5 702
37
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
38
Tacrolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 104987-11-3 445643 439492
39
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Phase 1 378-44-9 9782
40
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
41 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1
42
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
43
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
44
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
45
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
46
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
47
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
48
Atenolol Approved Phase 4,Phase 3,Phase 2 29122-68-7 2249
49
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
50
Sulfamethoxazole Approved Phase 4,Phase 2,Phase 3 723-46-6 5329

Interventional clinical trials:

(show top 50) (show all 4279)

id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan Unknown status NCT01051960 Phase 4 Ambrisentan
3 the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee Unknown status NCT02524509 Phase 4
4 Study of Endothelial Dysfunction in Systemic Lupus and Its Role in Heart Disease Unknown status NCT00188188 Phase 4 quinipril
5 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4 Rosuvastatin;Simvastatin
6 The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis Unknown status NCT02480335 Phase 4 bosentan
7 Superficial Basal Cell Carcinoma Treatment With Topical Photodynamic Therapy With Fractionated 5-aminolevulinic Acid 20% Versus Two Stage Methylaminolevulinate Unknown status NCT01491711 Phase 4 Methylaminolevulinate PDT in 2 sessions;Fractionated 5-aminolevulinic acid hydrochloride 20% gel PDT
8 An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst Unknown status NCT02154789 Phase 4 polidocanol
9 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
10 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
11 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
12 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
13 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
14 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4
15 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
16 Bucillamine Study of Holding Remission After Infliximab Dose-off Unknown status NCT00716248 Phase 4 bucillamine;methotrexate
17 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
18 Hanyang University Medical Center Arthritis Network Unknown status NCT00418405 Phase 4
19 Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis Unknown status NCT00291915 Phase 4 Adalimumab;Methotrexate
20 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
21 Withdrawal of Etanercept After Successful Treatment of Juvenile Idiopathic Arthritis Unknown status NCT01287715 Phase 4 etanercept;etanercept
22 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4
23 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
24 Rheumatoid Arthritis Patients in Training Unknown status NCT00434200 Phase 4
25 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
26 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
27 Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis Unknown status NCT00216177 Phase 4 Infliximab;Adalimumab
28 REstore Working Ability in RheumatoiD Arthritis Unknown status NCT01405326 Phase 4
29 Etanercept and Methotrexate in Patients to Induce Remission in Early Arthritis (EMPIRE) Unknown status NCT01303874 Phase 4 Etanercept (ETN);Placebo
30 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
31 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
32 Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) Unknown status NCT01067430 Phase 4 Etoricoxib;Diclofenac
33 Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis Unknown status NCT01000441 Phase 4 infliximab, etanercept, adalimumab;abatacept, rituximab or tocilizumab
34 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
35 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4 Dienogest;Goserelin;Desogestrel
36 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease Unknown status NCT00815282 Phase 4 Human papilloma virus vaccine (cervarix)
37 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
38 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
39 Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate Unknown status NCT01270035 Phase 4 Adalimumab
40 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
41 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4 Anakinra;TNF alpha inhibitors
42 Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue Unknown status NCT00543166 Phase 4 dehydroepiandrosterone
43 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
44 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Unknown status NCT02539095 Phase 4
45 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
46 Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome Unknown status NCT02370550 Phase 4 Cyclosporin A;Prednisone;Placebo;Calcium carbonate D
47 Influenza Vaccination in Patients With Scleroderma Unknown status NCT01002508 Phase 4
48 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
49 Retinal Ganglion Cell Function After Intravitreous Ranibizumab in Patients With Diabetic Macular Edema Unknown status NCT02055911 Phase 4 Ranibizumab
50 VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension Completed NCT01889966 Phase 4 Sildenafil

Search NIH Clinical Center for Connective Tissue Disease

Cochrane evidence based reviews: connective tissue diseases

Genetic Tests for Connective Tissue Disease

Genetic tests related to Connective Tissue Disease:

id Genetic test Affiliating Genes
1 Abnormality of Connective Tissue 29

Anatomical Context for Connective Tissue Disease

MalaCards organs/tissues related to Connective Tissue Disease:

39
Skin, Bone, Lung, Heart, Eye, Testes, Endothelial

Publications for Connective Tissue Disease

Articles related to Connective Tissue Disease:

(show top 50) (show all 1103)
id Title Authors Year
1
Predictors of Favorable Responses to Immunosuppressive Treatment in Pulmonary Arterial Hypertension Associated With Connective Tissue Disease. ( 28904255 )
2017
2
Parvovirus B19 infection in an adult presenting with connective tissue disease-like symptoms: a report of the clinical and histological findings. ( 28633740 )
2017
3
Replacing a phosphodiesterase-5 inhibitor with riociguat in patients with connective tissue disease-associated pulmonary arterial hypertension: a case series. ( 28671485 )
2017
4
Major depression: An under reported neuropsychiatric manifestation of Mixed Connective Tissue Disease. ( 28753451 )
2017
5
Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review. ( 28923086 )
2017
6
Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist's point of view. ( 28704913 )
2017
7
Retinal Vasculitis and Choroidopathy in Pediatric-Onset Mixed Connective Tissue Disease. ( 28937479 )
2017
8
Four Cases of Pneumatosis Cystoides Intestinalis Complicated by Connective Tissue Diseases. ( 28458320 )
2017
9
Are the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and the undifferentiated connective tissue disease (UCTD) related to each other? A case-control study of environmental exposures. ( 28332072 )
2017
10
Successful treatment of Type B insulin resistance with mixed connective tissue disease by pulse glucocorticoids and cyclophosphamide. ( 28084020 )
2017
11
An unusual association between hemophagocytic lymphohistiocytosis, mixed connective tissue disease, and autoimmune hemolytic anemia: A case report. ( 28700492 )
2017
12
Intracranial lesion as onset symptom in a patient with early undifferentiated connective tissue disease: a case report. ( 28476103 )
2017
13
The risk of autoimmune connective tissue diseases in patients with atopy: A nationwide population-based cohort study. ( 28814359 )
2017
14
Inhibition of endocan attenuates monocrotaline-induced connective tissue disease related pulmonary arterial hypertension. ( 27912147 )
2017
15
Tadalafil in idiopathic or heritable pulmonary arterial hypertension (PAH) compared to PAH associated with connective tissue disease. ( 28279499 )
2017
16
Lack of Response to Intravenous Sodium Thiosulfate in Three Cases of Extensive Connective Tissue Disease-Associated Calcinosis Cutis. ( 28667747 )
2017
17
Autoantibody to scaffold attachment factor B (SAFB): A novel connective tissue disease-related autoantibody associated with interstitial lung disease. ( 27682649 )
2017
18
Undifferentiated connective tissue disease, fibromyalgia and the environmental factors. ( 28368979 )
2017
19
Pathologic Separation of Chronic Hypersensitivity Pneumonitis From Fibrotic Connective Tissue Disease-associated Interstitial Lung Disease. ( 28614213 )
2017
20
Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease. ( 28053878 )
2017
21
Undifferentiated connective tissue disease: predictors of evolution into definite disease. ( 28770704 )
2017
22
Protein-losing Gastroenteropathy Related to Mixed Connective Tissue Disease: A Case Report of a Successful Outcome and Literature Review. ( 28768981 )
2017
23
Connective tissue disease: Reflections on the EULAR recommendations for the treatment of systemic sclerosis. ( 28053333 )
2017
24
Open Thoracic and Thoraco-abdominal Aortic Repair in Patients with Connective Tissue Disease. ( 28916127 )
2017
25
Rituximab versus cyclophosphamide for the treatment of connective tissue disease-associated interstitial lung disease (RECITAL): study protocol for a randomised controlled trial. ( 28619061 )
2017
26
The correlation between miR-200c and the severity of interstitial lung disease associated with different connective tissue diseases. ( 27309544 )
2017
27
Marfan syndrome; A connective tissue disease at the crossroads of mechanotransduction, TGFI^ signaling and cell stemness. ( 28782645 )
2017
28
Pulmonary fibrosis in connective tissue disease (CTD): urgent challenges and opportunities. ( 28899080 )
2017
29
Interstitial lung disease in the connective tissue diseases; a paradigm shift in diagnosis and treatment. ( 28923440 )
2017
30
Review of Primary Cutaneous Mucinoses in Nonlupus Connective Tissue Diseases. ( 28673091 )
2017
31
Radiologic pleuroparenchymal fibroelastosis-like lesion in connective tissue disease-related interstitial lung disease. ( 28666014 )
2017
32
Facts and controversies in mixed connective tissue disease. ( 28864092 )
2017
33
Selexipag for the treatment of connective tissue disease-associated pulmonary arterial hypertension. ( 28818881 )
2017
34
Epidemiology of Mixed Connective Tissue Disease 1985-2014: A Population Based Study. ( 26946215 )
2016
35
SY 11-4 CONNECTIVE TISSUE DISEASE AND ITS ASSOCIATION WITH ARTERIAL HYPERTENSION. ( 27643119 )
2016
36
Undifferentiated connective tissue disease and interstitial lung disease: Trying to define patterns. ( 27979657 )
2016
37
Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation. ( 27986694 )
2016
38
Undifferentiated Connective Tissue Disease, Mixed Connective Tissue Disease, and Overlap Syndromes in Rheumatology. ( 27311225 )
2016
39
Evaluation of computer-based computer tomography stratification against outcome models in connective tissue disease-related interstitial lung disease: a patient outcome study. ( 27876024 )
2016
40
Immunity and early atherosclerosis in the course of systemic lupus erythematosus, mixed connective tissue disease and antiphospholipid syndrome. ( 27826173 )
2016
41
Connective tissue disease-related pulmonary arterial hypertension. ( 27421214 )
2016
42
Mixed connective tissue disease. ( 27421219 )
2016
43
The Prevalence of Atherosclerosis in Those with Inflammatory Connective Tissue Disease by Race, Age, and Traditional Risk Factors. ( 26842423 )
2016
44
Comment on: rituximab in autoimmune connective tissue disease-associated interstitial lung disease. ( 27550303 )
2016
45
Lupus erythematosus and localized scleroderma coexistent at the same sites: a rare presentation of overlap syndrome of connective-tissue diseases. ( 27274545 )
2016
46
Association of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional study. ( 26758437 )
2016
47
Pediatric Mixed Connective Tissue Disease. ( 27032791 )
2016
48
Pauci-Immune Crescentic Glomerulonephritis in Connective Tissue Disease. ( 27504208 )
2016
49
The risk of cancer in patients with connective tissue diseases but without dermatomyositis or polymyositis: A multicenter cohort study conducted over 15 years in China. ( 27474413 )
2016
50
Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China. ( 27683823 )
2016

Variations for Connective Tissue Disease

ClinVar genetic disease variations for Connective Tissue Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ACTA2 NM_001613.2(ACTA2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs387906592 GRCh37 Chromosome 10, 90701066: 90701066

Expression for Connective Tissue Disease

Search GEO for disease gene expression data for Connective Tissue Disease.

Pathways for Connective Tissue Disease

Pathways related to Connective Tissue Disease according to GeneCards Suite gene sharing:

(show all 40)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 ACTA2 ACVRL1 BMPR2 CD40LG COL3A1 COL5A1
2
Show member pathways
13.65 ACVRL1 BMPR2 CD40LG EDNRA IFNG IL10
3
Show member pathways
13.39 ACTA2 ACVRL1 BMPR2 CD40LG IL10 IL6
4
Show member pathways
13.21 ACTA2 ACVRL1 BMPR2 CD40LG IL10 IL6
5
Show member pathways
12.62 CD40LG HLA-DRB1 IFNG IL10 TNF
6
Show member pathways
12.56 HLA-DRB1 IFNG IL10 IL6 TNF
7 12.5 CD40LG IFNG IL10 TNF TNFSF13B
8
Show member pathways
12.35 CD40LG IFNG IL10 IL6 TNF
9
Show member pathways
12.35 CD40LG COL5A1 HLA-DRB1 HSPD1 IFNG IL10
10 12.16 HSPD1 IL10 IL6 TNF
11
Show member pathways
12.16 CD40LG HLA-DRB1 IFNG IL10 TNF
12
Show member pathways
12.12 IFNG IL10 IL6 TNF
13 12.05 HLA-DRB1 HSPD1 IFNG IL10 IL6 TNF
14 11.96 IFNG IL6 TNF TNFSF13B
15 11.93 IFNG IL10 IL6 TNF
16
Show member pathways
11.85 IFNG IL10 IL6 TNF
17 11.78 BMPR2 IFNG TNF
18
Show member pathways
11.78 CD40LG TNF TNFSF13B
19 11.78 COL3A1 IFNG IL10 IL6 TNF
20 11.75 IFNG IL10 TNF
21
Show member pathways
11.73 CD40LG IFNG TNF
22 11.73 IL10 IL6 TNF
23 11.72 HLA-DRB1 IFNG IL6 TNF TNFSF13B
24
Show member pathways
11.71 CD40LG TNF TNFSF13B
25 11.69 IFNG IL10 IL6 TNF
26 11.57 HSPD1 IL6 TNF
27
Show member pathways
11.56 CD40LG IFNG IL6 TNF
28 11.53 IFNG IL6 TNF
29 11.5 IL10 IL6 TNF
30 11.5 CD40LG IL10 IL6 TNF TNFSF13B
31 11.49 ACTA2 IFNG TNF
32 11.45 IFNG IL6 TNF
33
Show member pathways
11.38 IFNG IL10 TNF
34 11.31 IL10 IL6 TNF
35 11.28 CD40LG COL3A1 IFNG
36 11.28 IFNG IL10 IL6 TNF
37 11.25 IFNG IL6 TNF
38 11.24 CD40LG IFNG IL10 IL6 TNF
39 11.11 CD40LG IL10 IL6 TNF TNFSF13B
40 10.5 HLA-DRB1 IFNG IL10 IL6 TNF

GO Terms for Connective Tissue Disease

Cellular components related to Connective Tissue Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ADAMTS13 APOH CD40LG COL3A1 COL5A1 FBN1
2 extracellular matrix GO:0031012 9.77 APOH COL3A1 COL5A1 FBN1 HSPD1
3 endoplasmic reticulum lumen GO:0005788 9.72 ADAMTS13 COL3A1 COL5A1 FBN1 IL6
4 external side of plasma membrane GO:0009897 9.65 CD40LG HLA-DRB1 IFNG IL6 TNF
5 cell surface GO:0009986 9.56 ACVRL1 ADAMTS13 APOH BMPR2 CD40LG HLA-DRB1
6 extracellular space GO:0005615 9.47 ACTA2 ADAMTS13 APOH BMPR2 CD40LG COL3A1

Biological processes related to Connective Tissue Disease according to GeneCards Suite gene sharing:

(show all 39)
id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.94 COL3A1 COL5A1 FBN1 TNF
2 regulation of immune response GO:0050776 9.93 CD40LG COL3A1 IFNG TNFSF13B
3 T cell costimulation GO:0031295 9.84 CD40LG HLA-DRB1 TNFSF13B
4 response to glucocorticoid GO:0051384 9.83 IL10 IL6 TNF
5 regulation of blood pressure GO:0008217 9.83 ACTA2 ACVRL1 EDNRA
6 positive regulation of endothelial cell proliferation GO:0001938 9.83 ACVRL1 BMPR2 IL10
7 humoral immune response GO:0006959 9.79 IFNG IL6 TNF
8 positive regulation of interleukin-6 production GO:0032755 9.76 HSPD1 IL6 TNF
9 platelet activation GO:0030168 9.76 ADAMTS13 CD40LG COL3A1 IL6
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IFNG IL6 TNF
11 negative regulation of endothelial cell proliferation GO:0001937 9.71 ACVRL1 APOH TNF
12 B cell proliferation GO:0042100 9.7 CD40LG HSPD1 IL10
13 immune response GO:0006955 9.7 CD40LG HLA-DRB1 IFNG IL10 IL6 TNF
14 negative regulation of DNA biosynthetic process GO:2000279 9.68 ACVRL1 BMPR2
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL10 TNF
16 lymphangiogenesis GO:0001946 9.67 ACVRL1 BMPR2
17 positive regulation of protein import into nucleus, translocation GO:0033160 9.67 IFNG IL6
18 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IFNG TNF
19 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
20 wound healing, spreading of epidermal cells GO:0035313 9.64 ACVRL1 COL5A1
21 artery development GO:0060840 9.63 ACVRL1 BMPR2
22 retina vasculature development in camera-type eye GO:0061298 9.62 ACVRL1 BMPR2
23 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IFNG IL10
24 lymphatic endothelial cell differentiation GO:0060836 9.61 ACVRL1 BMPR2
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.6 IL10 TNF
26 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.59 IL6 TNF
27 immunoglobulin secretion GO:0048305 9.58 CD40LG TNFSF13B
28 positive regulation of interleukin-12 production GO:0032735 9.58 CD40LG HSPD1 IFNG
29 regulation of immunoglobulin secretion GO:0051023 9.57 CD40LG TNF
30 positive regulation of T cell proliferation GO:0042102 9.56 CD40LG IFNG IL6 TNFSF13B
31 venous blood vessel development GO:0060841 9.55 ACVRL1 BMPR2
32 defense response to protozoan GO:0042832 9.54 IFNG IL10 IL6
33 receptor biosynthetic process GO:0032800 9.51 IL10 TNF
34 negative regulation of growth of symbiont in host GO:0044130 9.5 IFNG IL10 TNF
35 neutrophil apoptotic process GO:0001781 9.49 IFNG IL6
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IFNG TNF
37 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 IFNG TNF
38 cellular response to lipopolysaccharide GO:0071222 9.35 ADAMTS13 IFNG IL10 IL6 TNF
39 endothelial cell apoptotic process GO:0072577 8.8 BMPR2 IL10 TNF

Molecular functions related to Connective Tissue Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.5 COL3A1 COL5A1 FBN1
2 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.4 ACVRL1 BMPR2
3 platelet-derived growth factor binding GO:0048407 9.37 COL3A1 COL5A1
4 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG TNF TNFSF13B
5 BMP receptor activity GO:0098821 9.26 ACVRL1 BMPR2
6 integrin binding GO:0005178 9.26 ADAMTS13 COL3A1 COL5A1 FBN1
7 cytokine activity GO:0005125 9.1 CD40LG IFNG IL10 IL6 TNF TNFSF13B