MCID: CNN003
MIFTS: 48

Conn's Syndrome malady

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Conn's Syndrome

Aliases & Descriptions for Conn's Syndrome:

Name: Conn's Syndrome 12 14
Primary Hyperaldosteronism 12 50 29
Primary Aldosteronism 12 50 14
Conn Syndrome 12 50 69
Hyperaldosteronism 42 69
Mineralocorticoid Excess 50
Aldosteronism Primary 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12028
ICD10 33 E26.0 E26.01
ICD9CM 35 255.12
MeSH 42 D006929
NCIt 47 C34510
UMLS 69 C1384514

Summaries for Conn's Syndrome

NIH Rare Diseases : 50 primary hyperaldosteronism is a disorder caused by excess production of the hormone aldosterone by the adrenal glands. the main symptom of primary hyperaldosteronism is high blood pressure (hypertension), but other symptoms may include headaches, weakness, swelling (edema), and muscle spasms (tetany). the cause of primary hyperaldosteronism can vary. one cause may be an adenoma, or benign tumor, on the adrenal glands, which causes them to produce too much aldosterone. if primary hyperaldosteronism is caused by an adenoma, it is known as conn’s syndrome. the condition may also be caused by enlarged adrenal glands without adenomas (adrenal hyperplasia).  in some cases, primary hyperaldosteronism is inherited in an autosomal dominant manner, but in most cases the exact cause of the disease is unknown (idiopathic). a diagnosis is made by testing the blood for high levels of aldosterone. treatment for conn’s syndrome includes surgical removal of the adenomas. medication is used to treat primary hyperaldosteronism if it is caused by adrenal hyperplasia. last updated: 7/26/2016

MalaCards based summary : Conn's Syndrome, also known as primary hyperaldosteronism, is related to hyperaldosteronism, familial, type iii and apparent mineralocorticoid excess. An important gene associated with Conn's Syndrome is REN (Renin), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Insulin secretion. The drugs Epinephrine and Bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and kidney, and related phenotypes are Increased transferrin (TF) endocytosis and cardiovascular system

Disease Ontology : 12 An adrenal admenoma characterized by over production of aldosterone.

Related Diseases for Conn's Syndrome

Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 hyperaldosteronism, familial, type iii 32.2 NR3C2 REN
2 apparent mineralocorticoid excess 12.6
3 primary aldosteronism, seizures, and neurologic abnormalities 12.2
4 familial hyperaldosteronism 11.2
5 adrenal cortical carcinoma 10.9
6 smith-mccort dysplasia 2 10.3 NR3C2 REN
7 dystonia 25 10.2 NR3C2 REN
8 spastic ataxia 3 10.2 CYP11B1 CYP11B2
9 glossopharyngeal nerve neoplasm 10.2 POMC REN
10 endometrial mixed adenocarcinoma 10.2 POMC REN
11 cascade stomach 10.2 AGTR1 REN
12 hyperuricemic nephropathy, familial juvenile 2 10.2 AGTR1 REN
13 bronchiectasis with or without elevated sweat chloride 3 10.2 CYP11B2 NR3C2 REN
14 prostate neuroendocrine neoplasm 10.2 AGTR1 NR3C2 REN
15 laryngostenosis 10.2 AGTR1 CYP11B2 NR3C2
16 hemorrhagic cystitis 10.2 AGTR1 NR3C2 REN
17 cleft lip palate-tetraphocomelia 10.1 CYP21A2 POMC
18 aplasia cutis congenita recessive 10.1 AGTR1 CYP11B2
19 familial multiple trichodiscomas 10.1 POMC REN
20 cataract 21, multiple types 10.1 NR3C2 POMC REN
21 shaken baby syndrome 10.1 NPPA REN
22 aorta angiosarcoma 10.1 NR3C2 POMC REN
23 achromatopsia 10.1 NPPA REN
24 calcinosis 10.1 AGTR1 POMC REN
25 borderline personality disorder 10.1 CYP17A1 CYP21A2
26 bent bone dysplasia syndrome 10.1 CYP17A1 CYP21A2
27 myositis fibrosa 10.1 AGTR1 KCNJ5
28 iris disease 10.0 AGTR1 NPPA REN
29 bladder colonic type adenocarcinoma 10.0 CYP11B1 CYP11B2 POMC
30 eastern equine encephalitis 10.0 AGTR1 NPPA REN
31 epidemic typhus 10.0 CYP17A1 CYP21A2
32 lymphadenitis 10.0 AGTR1 NPPA REN
33 vestibular gland benign neoplasm 10.0 CYP11B2 KCNJ5 POMC REN
34 syringomelia hyperkeratosis 10.0 NPPA POMC
35 intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.0 AGTR1 CYP11B1 CYP11B2 KCNJ5
36 myopia 10.0 NPPA REN
37 flat umbilicus familial 10.0 AGTR1 REN
38 iida kannari syndrome 10.0 NPPA NR3C2
39 microphthalmia, isolated, with coloboma 7 10.0 CYP11B2 CYP21A2 NR3C2 REN
40 posterior uveal melanoma 10.0 CYP11B1 CYP21A2 POMC
41 dyt1 early-onset isolated dystonia 10.0 CYP17A1 CYP21A2 POMC
42 x-linked sideroblastic anemia with ataxia 10.0 CYP11A1 CYP17A1 POMC
43 sphingolipidosis 10.0 CYP17A1 CYP21A2 POMC
44 pelvic muscle wasting 10.0 CYP17A1 CYP21A2 POMC
45 deafness, autosomal recessive 29 9.9 CYP11A1 CYP17A1 CYP21A2
46 tick-borne encephalitis 9.9 CYP11A1 CYP17A1 CYP21A2
47 liver sarcoma 9.9 CYP11A1 CYP17A1 CYP21A2
48 hypogonadism mitral valve prolapse mental retardation 9.9 CYP11B2 NPPA POMC REN
49 benign peritoneal mesothelioma 9.9 CYP11B1 CYP11B2 CYP21A2 POMC
50 primary biliary cirrhosis 9.9 CYP11A1 CYP17A1 CYP21A2

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to Conn's Syndrome

Symptoms & Phenotypes for Conn's Syndrome

GenomeRNAi Phenotypes related to Conn's Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.28 NPPA NR3C2 POMC PRSS8 REN CYP11A1

MGI Mouse Phenotypes related to Conn's Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 KCNJ5 NPPA NR3C2 POMC REN AGTR1
2 growth/size/body region MP:0005378 9.86 AGTR1 CYP11A1 CYP11B1 CYP11B2 NR3C2 POMC
3 hematopoietic system MP:0005397 9.76 PRSS8 REN AGTR1 CYP11A1 CYP11B2 NPPA
4 homeostasis/metabolism MP:0005376 9.65 AGTR1 CYP11A1 CYP11B1 CYP11B2 CYP17A1 NPPA
5 renal/urinary system MP:0005367 9.17 AGTR1 CYP11B1 CYP11B2 NPPA NR3C2 POMC

Drugs & Therapeutics for Conn's Syndrome

Drugs for Conn's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Captopril Approved Phase 4 62571-86-2 44093
5
Eplerenone Approved Phase 4,Phase 3 107724-20-9 150310 443872
6
Spironolactone Approved Phase 4,Phase 3 1952-01-7, 52-01-7 5833
7
Losartan Approved Phase 4 114798-26-4 3961
8 Adrenergic Agents Phase 4,Phase 3,Phase 2
9 Adrenergic Agonists Phase 4,Phase 3,Phase 2
10 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
11 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
12 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
13 Autonomic Agents Phase 4,Phase 3,Phase 2
14 Bronchodilator Agents Phase 4,Phase 3,Phase 2
15 Epinephryl borate Phase 4,Phase 3,Phase 2
16 Mydriatics Phase 4,Phase 3,Phase 2
17 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
18 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
19 Racepinephrine Phase 4,Phase 3,Phase 2
20 Respiratory System Agents Phase 4,Phase 3,Phase 2
21 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
22 Antiparkinson Agents Phase 4
23 Dopamine Agents Phase 4
24 Dopamine agonists Phase 4
25 Hormone Antagonists Phase 4,Phase 3,Phase 2
26 Hormones Phase 4,Phase 3,Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
28 Angiotensin-Converting Enzyme Inhibitors Phase 4
29 Antihypertensive Agents Phase 4
30 HIV Protease Inhibitors Phase 4
31
protease inhibitors Phase 4
32 diuretics Phase 4,Phase 3
33 Diuretics, Potassium Sparing Phase 4,Phase 3
34 insulin Phase 4
35 Insulin, Globin Zinc Phase 4
36 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3
37 Mineralocorticoids Phase 4,Phase 3
38 Natriuretic Agents Phase 4,Phase 3
39
Angiotensin II Phase 4 68521-88-0, 11128-99-7 65143 172198
40 Angiotensin II Type 1 Receptor Blockers Phase 4
41 Angiotensin Receptor Antagonists Phase 4
42 Angiotensinogen Phase 4
43 Anti-Arrhythmia Agents Phase 4
44 Coagulants Phase 4
45 Fertility Agents Phase 4
46 Kallikreins Phase 4
47
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2 50-23-7 5754 657311
48
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
49 Anesthetics Phase 2, Phase 3
50 Adrenocorticotropic Hormone Phase 3

Interventional clinical trials:

(show all 47)
id Name Status NCT ID Phase
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4
2 The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism Unknown status NCT00451672 Phase 4
3 Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism Completed NCT00155064 Phase 4
4 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
5 Aldosterone Antagonism and Microvascular Function Recruiting NCT01887119 Phase 4
6 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
7 Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension Completed NCT00138944 Phase 3
8 Dynamic Hormone Diagnostics in Endocrine Disease Not yet recruiting NCT02934399 Phase 2, Phase 3
9 Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary Hyperaldosteronism Completed NCT00732771 Phase 2
10 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Recruiting NCT03174171 Phase 2
11 Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism Unknown status NCT00173082
12 Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Unknown status NCT01267747
13 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
14 Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity Unknown status NCT00917345
15 Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives. Unknown status NCT00407784
16 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
17 Anesthesia Management of Retroperitoneal Adrenalectomies Unknown status NCT00894335
18 Optimizing Diagnosis Of Primary Aldosteronism Completed NCT02755519
19 The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism Completed NCT02216721
20 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
21 Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in China Completed NCT01459042
22 Intraoperative Analysis of Cortisol During Adrenal Vein Sampling Completed NCT01761344
23 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501
24 Study of Myocardial Interstitial Fibrosis in Hyperaldosteronism Completed NCT02938910
25 Adrenal Vein Sampling International Study (AVIS Study) Completed NCT01234220
26 Aldosterone, Microvascular Function and Salt-sensitivity Completed NCT02068781
27 Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment Completed NCT01897727
28 Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure Completed NCT00001176
29 Screening for Primary Aldosteronism in a Population of Patients With Hypertension Recruiting NCT03105531
30 Primary Aldosteronism In Hypertensive Patients in China Recruiting NCT03155139
31 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847
32 Primary Aldosteronism in Western Norway Recruiting NCT02832388
33 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308
34 Renal Sympathetic Denervation From The Adventitia on Hypertension Recruiting NCT02642445
35 Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study) Recruiting NCT02804321
36 Adrenal Tumors - Pathogenesis and Therapy Recruiting NCT00669266
37 Omics Signature in the Diagnosis of Hypertension Recruiting NCT02772315
38 The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension Recruiting NCT01996449
39 Study of CS-3150 in Patients With Primary Aldosteronism Active, not recruiting NCT02885662
40 11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism Active, not recruiting NCT01567111
41 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Active, not recruiting NCT02030587
42 Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy Active, not recruiting NCT01676025
43 Primary Hyperaldosteronism and Ischemia-reperfusion Injury Enrolling by invitation NCT01978132
44 Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study Enrolling by invitation NCT02257450
45 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism Not yet recruiting NCT02756754
46 IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism Not yet recruiting NCT02945904
47 Microvascular Function in Primary Aldosteronism Withdrawn NCT02096939

Search NIH Clinical Center for Conn's Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hyperaldosteronism

Genetic Tests for Conn's Syndrome

Genetic tests related to Conn's Syndrome:

id Genetic test Affiliating Genes
1 Primary Hyperaldosteronism 29

Anatomical Context for Conn's Syndrome

MalaCards organs/tissues related to Conn's Syndrome:

39
Adrenal Gland, Testes, Kidney, Cortex, Skeletal Muscle, Adrenal Cortex

Publications for Conn's Syndrome

Articles related to Conn's Syndrome:

(show top 50) (show all 125)
id Title Authors Year
1
Clinical Case of the Month: PERSISTENT HYPERTENSION IN A YOUNG WOMAN: A CLASSIC PRESENTATION OF CONN'S SYNDROME. ( 26986864 )
2016
2
Aldosterone deficiency after unilateral adrenalectomy for Conn's syndrome: a case report and literature review. ( 25604311 )
2015
3
Contralateral adrenal abnormalities in Conn's syndrome. ( 26237993 )
2015
4
Adrenal Vein Sampling for Conn's Syndrome: Diagnosis and Clinical Outcomes. ( 26854152 )
2015
5
Cortex sparing laparoscopic adrenalectomy in a patient with Conn's syndrome. ( 25931842 )
2013
6
Hypokalemia- induced myopathy and massive creatine kinase elevation as first manifestation of Conn's syndrome. ( 24249961 )
2013
7
A case of Conn's syndrome presenting with painfull muscular weakness. ( 23715367 )
2013
8
KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome. ( 22323562 )
2012
9
Conn's syndrome unmasked by thiazide-induced hypokalaemia. ( 22041837 )
2011
10
Aldosterone increases Na+ -K+ -ATPase activity in skeletal muscle of patients with Conn's syndrome. ( 21044117 )
2011
11
Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report. ( 21980052 )
2011
12
A case of Conn's syndrome revealed after oral sodium phosphate (Fleet) preparation for colonoscopy. ( 20402838 )
2010
13
Is hyperaldosteronism a pathognomonic feature of conn's syndrome? ( 23133229 )
2010
14
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. ( 20953222 )
2010
15
Laparoscopic adrenalectomy for Conn's syndrome: report of the initial six cases. ( 20099423 )
2009
16
Conn's syndrome. ( 19190201 )
2009
17
[Conn's syndrome]. ( 19099278 )
2009
18
Retroperitoneoscopic adrenalectomy in Conn's syndrome caused by adrenal adenomas or nodular hyperplasia. ( 18343972 )
2008
19
Open adrenalectomy surgery: an obsolete technique? About a case of Conn's syndrome. ( 18572739 )
2008
20
Delay in the diagnosis of Conn's syndrome: a single-center experience over 30 years. ( 18663152 )
2008
21
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. ( 18772856 )
2008
22
Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. ( 18543405 )
2008
23
Long-term results of endoscopic adrenalectomy for Conn's syndrome. ( 17305298 )
2007
24
Conn's syndrome in pregnancy successfully treated with amiloride. ( 17999306 )
2007
25
Lessons in the diagnosis and management of Conn's syndrome. ( 17990731 )
2007
26
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. ( 17315030 )
2007
27
Laparoscopic adrenalectomy for Conn's syndrome. ( 16441999 )
2006
28
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). ( 17100688 )
2006
29
Association between Crohn's disease and Conn's syndrome. A report of two cases. ( 15985978 )
2005
30
Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn's syndrome with an ominous clinical course. ( 15788646 )
2005
31
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. ( 15751612 )
2005
32
Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn's syndrome. ( 16222471 )
2005
33
Conn's syndrome presenting as depression. ( 15930081 )
2005
34
Shift from Conn's syndrome to Cushing's syndrome in a recurrent adrenocortical carcinoma. ( 16260420 )
2005
35
Conn's syndrome (primary hyperaldosteronism) simulating polymyositis. ( 15034751 )
2005
36
Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome). ( 15241622 )
2004
37
Renal transplantation unveils Conn's syndrome: a case report. ( 15621124 )
2004
38
Roentgenoendovascular treatment of Conn's syndrome. ( 15622394 )
2004
39
Laparoscopic adrenalectomy for Conn's syndrome complicated by ipsilateral congenital pelvic kidney. ( 15791386 )
2004
40
Conn's syndrome associated with Behcet's disease. ( 12589107 )
2003
41
CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. ( 12933492 )
2003
42
Hypokalemic rhabdomyolysis aggravated by diuretics complicating Conn's syndrome without acute renal failure. ( 11837808 )
2002
43
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. ( 11827421 )
2001
44
Outpatient laparoscopic adrenalectomy in patients with Conn's syndrome. ( 11591947 )
2001
45
Conn's syndrome and bilateral renal artery stenosis in the presence of multiple renal arteries. ( 11383914 )
2001
46
Conn's syndrome and atrial fibrillation. ( 11421216 )
2001
47
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). ( 11422106 )
2001
48
Soft-tissue images. Adrenocortical adenocarcinoma presenting as Conn's syndrome. ( 10223065 )
1999
49
Conn's syndrome: a simple diagnostic approach. ( 10613001 )
1999
50
Clinics in diagnostic imaging (39). Conn's syndrome due to adrenocortical adenoma (Conn's tumour). ( 10560278 )
1999

Variations for Conn's Syndrome

ClinVar genetic disease variations for Conn's Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CACNA1H NM_021098.2(CACNA1H): c.4645A> G (p.Met1549Val) single nucleotide variant Pathogenic rs786205050 GRCh38 Chromosome 16, 1212024: 1212024

Expression for Conn's Syndrome

Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for Conn's Syndrome

Pathways related to Conn's Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
2
Show member pathways
12.1 AGTR1 CYP11A1 CYP11B2 CYP21A2
3 11.59 CYP11A1 CYP11B1 CYP21A2 POMC
4
Show member pathways
11.46 AGTR1 CYP11B2 NR3C2 REN
5
Show member pathways
11.16 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
6
Show member pathways
11.04 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
7
Show member pathways
10.78 CYP11B1 CYP11B2 CYP17A1 CYP21A2

GO Terms for Conn's Syndrome

Cellular components related to Conn's Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial membrane GO:0031966 8.8 CYP11A1 CYP11B1 CYP11B2

Biological processes related to Conn's Syndrome according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.91 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
2 regulation of blood pressure GO:0008217 9.67 CYP11B1 NPPA POMC REN
3 steroid metabolic process GO:0008202 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
4 C21-steroid hormone biosynthetic process GO:0006700 9.5 CYP11A1 CYP11B1 CYP11B2
5 cellular response to potassium ion GO:0035865 9.49 CYP11B1 CYP11B2
6 renin-angiotensin regulation of aldosterone production GO:0002018 9.48 AGTR1 REN
7 mineralocorticoid biosynthetic process GO:0006705 9.46 CYP11B2 CYP21A2
8 aldosterone biosynthetic process GO:0032342 9.43 CYP11B1 CYP11B2
9 glucocorticoid biosynthetic process GO:0006704 9.43 CYP11B1 CYP17A1 CYP21A2
10 cortisol biosynthetic process GO:0034651 9.4 CYP11B1 CYP11B2
11 steroid biosynthetic process GO:0006694 9.35 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
12 sterol metabolic process GO:0016125 9.02 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Molecular functions related to Conn's Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.77 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
2 iron ion binding GO:0005506 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
3 steroid binding GO:0005496 9.43 CYP21A2 NR3C2
4 steroid hydroxylase activity GO:0008395 9.4 CYP11B2 CYP21A2
5 heme binding GO:0020037 9.35 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
6 corticosterone 18-monooxygenase activity GO:0047783 9.32 CYP11B1 CYP11B2
7 steroid 11-beta-monooxygenase activity GO:0004507 9.26 CYP11B1 CYP11B2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.02 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Sources for Conn's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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