MCID: CNN003
MIFTS: 47

Conn's Syndrome malady

Rare diseases, Cancer diseases categories
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Summaries for Conn's Syndrome

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 An adrenal admenoma characterized by over production of aldosterone.

MalaCards: Conn's Syndrome, also known as primary hyperaldosteronism, is related to hyperaldosteronism and hypertension. An important gene associated with Conn's Syndrome is REN (renin), and among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds 18-hydroxycorticosterone and benazepril have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and cortex, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Conn's Syndrome

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

conn's syndrome 8 43
primary hyperaldosteronism 8 43
primary aldosteronism 8 43
primary aldosteronism, hypokalemic alkalosis, hypertension and muscle weakness 43
aldosteronism primary 45
conns syndrome 10
conn syndrome 8


External Ids:

Disease Ontology8 DOID:12028
ICD9CM27 255.12
NCIt40 C34510
MeSH35 D006929

Related Diseases for Conn's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1hyperaldosteronism31.7CYP11B2, KCNJ5, REN, NR3C2
2hypertension31.2NR3C2, REN, CYP11B2
3adenoma30.8CYP11B2, KCNJ5, INHA, REN, NR3C2
4adrenal adenoma30.7REN, INHA
5low renin hypertension30.7REN, CYP11B2
6essential hypertension30.7CYP11B2, REN, NR3C2
7hypokalemia30.6CYP11B2, REN, NR3C2
8cushing's syndrome30.5REN, CYP11B2
9adrenocortical carcinoma30.3INHA, CYP11B2
10hypoaldosteronism30.3CYP11B2, REN
11glucocorticoid-remediable aldosteronism30.1NR3C2, REN, CYP11B2
12diabetes mellitus30.0NR3C2, REN, KCNJ5
13proteinuria30.0NR3C2, REN, CYP11B2
14myocardial infarction29.9CYP11B2, KCNJ5, REN, NR3C2
15malignant hypertension10.4
16familial hyperaldosteronism10.4
17primary hyperparathyroidism10.3
18hyperparathyroidism10.3
19myopathy10.3
20thyroiditis10.2
21kidney disease10.2
22hyperaldosteronism, familial, type iii10.2
23renovascular hypertension10.2
24nephrocalcinosis10.2
25adrenal carcinoma10.2
26primary aldosteronism, seizures, and neurologic abnormalities10.2
27polycystic kidney disease10.1
28twin-to-twin transfusion syndrome10.1
29familial partial lipodystrophy10.1
30vitiligo10.1
31hypokalemic periodic paralysis10.1
32artery disease10.1
33hepatitis10.1
34hypothyroidism10.1
35lipodystrophy10.1
36peritonitis10.1
37renal artery disease10.1
38familial hyperaldosteronism type 210.1
39glucagonoma10.1
40polymyositis10.1
41pseudohypoaldosteronism type ii10.0REN, NR3C2
42pseudohypoaldosteronism10.0NR3C2, REN
43congenital adrenal hyperplasia10.0CYP11B2, REN
44renal fibrosis10.0REN, NR3C2
45addison's disease10.0REN, CYP11B2
46metabolic acidosis10.0NR3C2, REN
47gynecomastia10.0INHA, NR3C2
48diabetic nephropathy10.0NR3C2, REN
49polycystic ovary syndrome10.0NR3C2, INHA
50wilms tumor10.0INHA, REN

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Symptoms for Conn's Syndrome

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Drugs & Therapeutics for Conn's Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Conn's Syndrome

Search NIH Clinical Center for Conn's Syndrome

Genetic Tests for Conn's Syndrome

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Anatomical Context for Conn's Syndrome

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33MalaCards
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MalaCards organs/tissues related to Conn's Syndrome:

33
Kidney, Adrenal gland, Cortex, Skeletal muscle, Testes, Adrenal cortex

Animal Models for Conn's Syndrome or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Conn's Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.0NR3C2, REN, CYP11B2
2MP:00053678.9CYP11B2, REN, NR3C2
3MP:00053788.4CYP11B2, INHA, REN, NR3C2
4MP:00053768.1NR3C2, REN, INHA, CYP11B2
5MP:00053857.6NR3C2, REN, INHA, KCNJ5, CYP11B2

Publications for Conn's Syndrome

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Sources:
52PubMed
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Articles related to Conn's Syndrome:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. (20953222)
2010
2
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. (18772856)
2008
3
Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. (18543405)
2008
4
Lessons in the diagnosis and management of Conn's syndrome. (17990731)
2007
5
Conn's syndrome in pregnancy successfully treated with amiloride. (17999306)
2007
6
Long-term results of endoscopic adrenalectomy for Conn's syndrome. (17305298)
2007
7
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. (17315030)
2007
8
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
9
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
10
Association between Crohn's disease and Conn's syndrome. A report of two cases. (15985978)
2005
11
Roentgenoendovascular treatment of Conn's syndrome. (15622394)
2004
12
Laparoscopic adrenalectomy for Conn's syndrome complicated by ipsilateral congenital pelvic kidney. (15791386)
2004
13
Conn's syndrome associated with Behcet's disease. (12589107)
2003
14
CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. (12933492)
2003
15
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). (11422106)
2001
16
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. (11827421)
2001
17
Clinics in diagnostic imaging (39). Conn's syndrome due to adrenocortical adenoma (Conn's tumour). (10560278)
1999
18
Conn's syndrome: a simple diagnostic approach. (10613001)
1999
19
Anaesthesia for Conn's syndrome. (10403872)
1999
20
Calcium-channel blockade can mask the diagnosis of Conn's syndrome. (10715768)
1999
21
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes. (9863625)
1998
22
Primary aldosteronism (Conn's syndrome). (8530580)
1995
23
Refractory hypertension due to Conn's syndrome. (8121854)
1994
24
Altered primary haemostasis in Conn's syndrome. (1448795)
1992
25
Conn's syndrome. (2246200)
1990
26
Conn's syndrome with rhabdomyolysis mimicking deep vein thrombophlebitis. (2315785)
1990
27
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988
28
Pheochromocytoma and Conn's syndrome in Denmark 1977-1981. (3472432)
1986
29
Quantitative selenium-75-cholesterol imaging and computed tomography of the adrenal glands in Conn's syndrome. (7135126)
1982
30
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. (7014043)
1981
31
Conn's syndrome in a patient with acromegaly. (7016705)
1981
32
Primary hyperparathyroidism in a patient with Conn's syndrome. (7383950)
1980
33
The structure of the juxtaglomerular apparatus in Addison's disease, Bartter's syndrome, and in Conn's syndrome: a comparative, morphometric, light microscopic study on serial secions. (818792)
1976
34
Nursing care study: Conn's syndrome. (1044099)
1976
35
Conn's syndrome. (4699809)
1973
36
Urinary excretion of tetrahydroaldosterone in normal subjects and in patients with adrenal insufficiency and Conn's syndrome. (4678197)
1972
37
The diagnosis of primary aldosteronism (Conn's syndrome). (A case report). (5025979)
1972
38
Studies on the biosynthesis of aldosterone in solitary adenoma and in nodular hyperplasia of the adrenal cortex in patients exhibiting Conn's syndrome. (5395005)
1969
39
Renal mastocytosis in a case of Conn's syndrome. (5602588)
1967
40
The aldosterone-renin constellation in Conn's syndrome. (4294143)
1967
41
Conn's syndrome. A detailed study on corticoid metabolites in the urine in two operated cases. (5908976)
1966
42
HYPOKALEMIC ALKALOSIS WITH ADRENAL TUMOR: A CASE REPORT. CONN'S SYNDROME OR DRUG-INDUCED HYPOKALEMIC ALKALOSIS. (14256705)
1965
43
CONN'S SYNDROME WITH ASSOCIATED PREGNANCY. (14341826)
1965
44
PLASMA RENIN IN A CASE OF CONN'S SYNDROME WITH FIBRINOID LESIONS: USE OF SPINONOLACTONE IN TREATMENT. (14213078)
1964
45
CATHETERIZATION OF THE LEFT ADRENAL VEIN FOR CONTRAST INJECTION AND STEROID ANALYSIS IN A CASE OF CONN'S SYNDROME. (14213891)
1964
46
CONN'S SYNDROME. (14077792)
1963
47
Modification of the effects of aldosterone on electrolyte excretion in man by simultaneous administration of corticosterone and hydrocortisone. Relevance to Conn's syndrome. (13854575)
1960
48
Conn's syndrome. (13591287)
1958
49
Conn's syndrome with severe hypertension. (13287082)
1956
50
Experimental production of morphological changes resembling Conn's syndrome. (13377711)
1956

Variations for Conn's Syndrome

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Expression for genes affiliated with Conn's Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conn's Syndrome

Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for genes affiliated with Conn's Syndrome

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG
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Pathways related to Conn's Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4REN, INHA
2
Show member pathways
9.0NR3C2, REN, CYP11B2

Compounds for genes affiliated with Conn's Syndrome

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Conn's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone45 2410.9REN, CYP11B2
2benazepril45 51 1111.9REN, CYP11B2
3glycyrrhetinic acid45 2410.8REN, NR3C2
4drospirenone45 29 51 1112.8REN, NR3C2
5Cortexolone249.8CYP11B2, NR3C2
6deoxycorticosterone29 2410.8NR3C2, CYP11B2
7glycyrrhizin45 2910.8NR3C2, REN
8hydralazine45 51 1111.8CYP11B2, REN
9cortisol29 2410.8NR3C2, CYP11B2
10thiazide459.8REN, NR3C2
11atenolol45 51 29 24 1113.8REN, CYP11B2
12irbesartan45 29 51 1112.8CYP11B2, REN
13aldosterone29 24 1111.8NR3C2, CYP11B2
14felodipine45 29 1111.7NR3C2, REN
15metyrapone45 61 1111.7CYP11B2, NR3C2
16metoclopramide45 51 1111.7CYP11B2, REN
1717-hydroxyprogesterone45 2410.7REN, CYP11B2
18cortisone45 2410.7NR3C2, CYP11B2
19candesartan45 51 29 1112.6CYP11B2, REN
20carbenoxolone45 29 1111.6REN, NR3C2
21enalapril45 51 1111.6REN, NR3C2
22tetrahydroaldosterone459.4CYP11B2, REN, NR3C2
23fludrocortisone45 29 1111.4NR3C2, REN, CYP11B2
24eplerenone45 61 29 1112.4CYP11B2, REN, NR3C2
2511 deoxycortisol459.4REN, NR3C2, CYP11B2
26doca459.4NR3C2, CYP11B2, REN
27hydrochlorothiazide45 29 51 24 1113.4CYP11B2, NR3C2, REN
28spironolactone45 61 29 51 1113.4CYP11B2, REN, NR3C2
2911beta-hydroxysteroid459.4CYP11B2, NR3C2, REN
30ang ii459.4REN, CYP11B2, NR3C2
31losartan45 51 29 1112.4NR3C2, CYP11B2, REN
32corticosterone45 61 2411.4NR3C2, CYP11B2, REN
33hydrocortisone45 3 61 1112.4CYP11B2, REN, NR3C2
34androstenedione45 2410.3INHA, REN, CYP11B2
353beta-hydroxysteroid459.2INHA, CYP11B2, NR3C2
36ribonucleic acid459.1INHA, CYP11B2, NR3C2
37nifedipine45 29 51 1112.0CYP11B2, KCNJ5, REN
38estradiol45 24 1110.9NR3C2, REN, INHA
39acth458.8CYP11B2, INHA, REN, NR3C2
40forskolin45 51 1110.8INHA, REN, CYP11B2
41steroid458.7REN, CYP11B2, NR3C2, INHA
42dopamine45 29 24 1111.7REN, KCNJ5, NR3C2
43haloperidol45 51 29 3 1112.6KCNJ5, REN, NR3C2, CYP11B2
44norepinephrine45 24 1110.6NR3C2, REN, KCNJ5, CYP11B2
45potassium45 24 1110.6NR3C2, REN, KCNJ5, CYP11B2
46sodium45 249.6NR3C2, REN, CYP11B2, KCNJ5
47nitric oxide45 24 1110.5CYP11B2, REN, KCNJ5, NR3C2
48glucose458.5REN, NR3C2, KCNJ5, CYP11B2
49testosterone45 61 24 1111.4NR3C2, INHA, KCNJ5, CYP11B2
50lysine458.3NR3C2, KCNJ5, CYP11B2

GO Terms for genes affiliated with Conn's Syndrome

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16Gene Ontology
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Biological processes related to Conn's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1male gonad developmentGO:0085849.4REN, INHA

Products for genes affiliated with Conn's Syndrome

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  • Antibodies
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Sources for Conn's Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet