MCID: CNN003
MIFTS: 49

Conn's Syndrome malady

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Conn's Syndrome

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Aliases & Descriptions for Conn's Syndrome:

Name: Conn's Syndrome 11 13
Primary Hyperaldosteronism 11 48 27
Primary Aldosteronism 11 48 13
Conn Syndrome 11 48 68
 
Hyperaldosteronism 39 68
Mineralocorticoid Excess 48
Aldosteronism Primary 50

Classifications:



External Ids:

Disease Ontology11 DOID:12028
ICD1030 E26.0, E26.01
ICD9CM32 255.12
MeSH39 D006929
NCIt45 C34510

Summaries for Conn's Syndrome

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NIH Rare Diseases:48 Primary hyperaldosteronism is a disorder caused by excess production of the hormone aldosterone by the adrenal glands. The main symptom of primary hyperaldosteronism is high blood pressure (hypertension), but other symptoms may include headaches, weakness, swelling (edema), and muscle spasms (tetany). The cause of primary hyperaldosteronism can vary. One cause may be an adenoma, or benign tumor, on the adrenal glands, which causes them to produce too much aldosterone. If primary hyperaldosteronism is caused by an adenoma, it is known as Conn’s syndrome. The condition may also be caused by enlarged adrenal glands without adenomas (adrenal hyperplasia).  In some cases, primary hyperaldosteronism is inherited in an autosomal dominant manner, but in most cases the exact cause of the disease is unknown (idiopathic). A diagnosis is made by testing the blood for high levels of aldosterone. Treatment for Conn’s syndrome includes surgical removal of the adenomas. Medication is used to treat primary hyperaldosteronism if it is caused by adrenal hyperplasia. Last updated: 7/26/2016

MalaCards based summary: Conn's Syndrome, also known as primary hyperaldosteronism, is related to apparent mineralocorticoid excess and primary aldosteronism, seizures, and neurologic abnormalities, and has symptoms including cushingoid facies, cushingoid facies and cushingoid facies. An important gene associated with Conn's Syndrome is REN (Renin), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Corticotropin-releasing hormone. The drugs spironolactone and spironolactone pwdr have been mentioned in the context of this disorder. Affiliated tissues include bone, adrenal gland and kidney, and related mouse phenotypes are Increased transferrin (TF) endocytosis and cardiovascular system.

Disease Ontology:11 An adrenal admenoma characterized by over production of aldosterone.

Related Diseases for Conn's Syndrome

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Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1apparent mineralocorticoid excess12.6
2primary aldosteronism, seizures, and neurologic abnormalities12.2
3familial hyperaldosteronism11.2
4adrenal cortical carcinoma10.9
5hyperaldosteronism, familial, type iv10.9
6hyperaldosteronism, familial, type iii10.8
7dystonia 2510.5NR3C2, REN
8carotid artery disease10.5POMC, REN
9gallbladder adenoma10.4POMC, REN
10silver-russell syndrome due to 7p11.2p13 microduplication10.4NPPA, REN
11actinic lichen planus10.4POMC, REN
12severe intellectual disability-epilepsy-anal anomalies-distal phalangeal hypoplasia10.4CYP11A1, REN
13repetitive motion disorders10.3NPPA, REN
14hidradenocarcinoma10.3CYP21A2, POMC
15craniopharyngioma10.3POMC, REN
16achromatopsia10.3NPPA, REN
17bronchiectasis with or without elevated sweat chloride 310.3CYP11B2, NR3C2, REN
18mental depression10.3NPPA, REN
19cataract 21, multiple types10.2NR3C2, POMC, REN
20acute liver failure10.2NPPA, REN
21central nervous system angiosarcoma10.2KCNJ5, POMC, REN
22astrakhan spotted fever10.2POMC, REN
23pfeiffer syndrome10.2CYP11A1, POMC
24bladder neck cancer10.2NPPA, REN
25peritoneal mesothelioma10.2CYP11B1, CYP11B2, POMC
26hypodermyasis10.2CYP11B2, NPPA, REN
27spinal canal and spinal cord meningioma10.1CYP11B2, NPPA, REN
28adrenal carcinoma10.1CYP21A2, POMC
29aortic valves stenosis of the child10.0AGTR1, CYP11B2
30broad ligament malignant neoplasm10.0AGTR1, REN
31male reproductive organ benign neoplasm10.0CYP11B2, KCNJ5, POMC, REN
32dfna2 nonsyndromic hearing loss10.0CYP17A1, CYP21A2, POMC
33renal tubular dysgenesis10.0AGTR1, REN
34centrotemporal epilepsy9.9CYP11A1, POMC
35adenocarcinoma9.9AGTR1, REN
36adrenal adenoma9.9
37adenoma9.9
38antiphospholipid syndrome9.9AGTR1, NR3C2, REN
39benign hypertensive renal disease9.8AGTR1, CYP11B2, NR3C2
40perrault syndrome9.8AGTR1, NR3C2, REN
4146 xx gonadal dysgenesis9.8CYP11A1, CYP17A1
42glioma susceptibility 19.8CYP11A1, CYP11B1, CYP11B2, POMC
43gemistocytic astrocytoma9.7AGTR1, POMC, REN
44hypoaldosteronism, congenital, due to cmo ii deficiency9.7CYP11B1, CYP11B2, NR3C2, POMC, REN
45keratoacanthoma9.7CYP21A2, POMC
46vestibular gland benign neoplasm9.7CYP11B1, CYP11B2, KCNJ5, POMC, REN
47dressler's syndrome9.7CYP11A1, CYP21A2, POMC, REN
48ovarian cancer9.7AGTR1, NPPA, REN
49chancroid9.7CYP11A1, CYP21A2, POMC, REN
50chylocele of tunica vaginalis9.7AGTR1, NPPA, REN

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Symptoms & Phenotypes for Conn's Syndrome

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UMLS symptoms related to Conn's Syndrome:


cushingoid facies

GenomeRNAi Phenotypes related to Conn's Syndrome according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00363-A7.5CYP11A1, CYP11B1, CYP11B2, CYP21A2, NPPA, NR3C2

MGI Mouse Phenotypes related to Conn's Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1AGTR1, CYP11B1, CYP11B2, KCNJ5, NPPA, NR3C2
2MP:00053787.8AGTR1, CYP11A1, CYP11B1, CYP11B2, NR3C2, POMC
3MP:00053977.6AGTR1, CYP11A1, CYP11B2, NPPA, NR3C2, POMC
4MP:00053677.6AGTR1, CYP11B1, CYP11B2, NPPA, NR3C2, POMC
5MP:00053766.8AGTR1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, NPPA

Drugs & Therapeutics for Conn's Syndrome

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Drugs for Conn's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 76)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Epinephrineapproved, vet_approvedPhase 4, Phase 3, Phase 293351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2
EplerenoneapprovedPhase 4, Phase 394107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
3
CaptoprilapprovedPhase 43262571-86-244093
Synonyms:
(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
(2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
(S)-1-(3-Mercapto-2-methyl-1-oxo-propyl)-L-proline
(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline
1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S)
1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
1j37
3-Mercapto-2-methylpropionyl-proline
62571-86-2
AC-12047
AC1L2B4L
AC1Q29GZ
AC1Q5R48
Acediur
Aceplus
Acepress
Acepril
Alopresin
Apopril
Apopril (TN)
Asisten
BB_NC-2104
BIM-0050290.0001
BPBio1_000063
BRD-K54529596-001-04-0
BSPBio_000057
BSPBio_002976
C 4042
C4042_SIAL
C4042_SIGMA
C8856_SIAL
C9H15NO3S
CHEBI:3380
CHEMBL1560
CHEMBL82
CID44093
CP
CPD0-2067
CPD000059061
Capoten
Capoten (TN)
Captolane
Captopril (JP15/USP/INN)
Captopril [USAN:INN:BAN:JAN]
Captoprilum
Captoprilum [INN-Latin]
Captopryl
Captoril
Captril
Cesplon
D-2-Methyl-3-mercaptopropanoyl-L-proline
D-3-Mercapto-2-methylpropanoyl-L-proline
D-3-Mercapto-2-methylpropionylproline
D00251
DB01197
Dilabar
DivK1c_000208
EINECS 263-607-1
EU-0100302
FT-0082749
Garranil
Garranil (discontinued)
HMS1921C12
HMS2089P19
 
HMS2092I12
HMS500K10
HSDB 6527
Hipertil
Hypertil
IDI1_000208
Isopresol
KBio1_000208
KBio2_001168
KBio2_003736
KBio2_006304
KBio3_002196
KBioGR_001321
KBioSS_001168
L-Captopril
LS-137465
Lopac-C-4042
Lopac0_000302
Lopirin
Lopirin [Switzerland]
Lopril
MCO
MLS000069484
MLS001076488
MolPort-001-794-639
N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
NCGC00015235-01
NCGC00015235-02
NCGC00023654-03
NCGC00023654-04
NCGC00023654-05
NCGC00023654-06
NCGC00023654-07
NCGC00023654-08
NCGC00023654-09
NCGC00023654-10
NINDS_000208
Prestwick3_000019
Prestwick_103
SA 333
SAM002564201
SMP1_000056
SMR000059061
SPBio_001022
SPECTRUM1500682
SQ 14,225
SQ 14225
SQ-14,225
SQ-14,534
SQ-14225
SQ-14534
ST079562
STK802012
Spectrum2_001211
Spectrum3_001388
Spectrum4_000811
Spectrum5_001587
Spectrum_000688
Tenosbon
Tensiomin
Tensobon
Tensoprel
UNII-9G64RSX1XD
UPCMLD-DP003
UPCMLD-DP003:001
X8Z
[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline
captopril
4
DopamineapprovedPhase 4375951-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
5
Bromocriptineapproved, investigationalPhase 43125614-03-331101
Synonyms:
(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman
(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione
(5'alpha)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-2'-(propan-2-yl)-3',6',18-trioxoergotaman
(5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman
(6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-alpha-(2-methylpropyl)ergotamin-3',6',18-trione
2-Bromo-alpha-ergocryptine
2-Bromo-alpha-ergokryptin
2-Bromo-alpha-ergokryptine
2-Bromoergocryptine Methanesulfonate
2-Bromoergokryptine
2-bromo-α-ergocryptine
2-bromo-α-ergokryptin
2-bromo-α-ergokryptine
22260-51-1 (mesylate (salt))
25614-03-3
AC-13601
AC1L1KXS
AC1Q2716
Alti-Bromocriptine
Apo-Bromocriptine
BIDD:GT0464
BPBio1_001131
BRD-K14496212-001-01-1
Bagren
Biomol-NT_000005
Bromergocryptine
Bromocriptin
Bromocriptina
Bromocriptina [INN-Spanish]
Bromocriptine (USAN/INN)
Bromocriptine Methanesulfonate
Bromocriptine [BAN]
Bromocriptine [USAN:BAN:INN]
 
Bromocriptine methanesulfonate
Bromocriptinum
Bromocriptinum [INN-Latin]
Bromocryptin
Bromocryptine
Bromoergocriptine
Bromoergocryptine
C06856
C32H40BrN5O5
CB-154
CCRIS 3244
CHEBI:3181
CHEMBL493
CID31101
D03165
DB01200
EINECS 247-128-5
Ergocryptine, 2-bromo- (8CI)
Ergoset
LS-64540
Lopac0_000171
MolPort-002-512-064
NCGC00024584-04
NCI60_001365
NSC169774
PDSP2_001500
Parlodel
Parlodel Snaptabs
Prestwick0_000121
Prestwick1_000121
Prestwick2_000121
SPBio_002101
UNII-3A64E3G5ZO
bromocriptine
nchembio873-comp18
6
SpironolactoneapprovedPhase 4, Phase 32221952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
7
LosartanapprovedPhase 4282114798-26-43961
Synonyms:
(2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
114798-26-4
124750-99-8 (mono-potassium salt)
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)
2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol
2-N-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol
2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole
AC1L1H3Q
BIDD:GT0286
BRD-K76205745-001-02-5
BSPBio_002695
C07072
C22H23ClN6O
CHEBI:6541
CHEMBL191
CID3961
CL23623
Cozaar
D08146
DB00678
DUP 89
DuP 89
DuP-753
HMS1922J13
HMS2093E22
Hyzaar
I14-9710
Jsp001094
KBio2_002193
 
KBio2_004761
KBio2_007329
KBio3_001915
KBioGR_001611
KBioSS_002193
L000351
LOSARTAN POTASSIUM
LS-78746
Lacidipine
Lortaan
Losartan
Losartan (INN)
Losartan Potassium
Losartan [INN:BAN]
Losartan monopotassium salt
Losartic
Losartic (TN)
MK-954
MK954
MolPort-003-666-553
NCGC00095125-01
NCGC00095125-02
NCGC00095125-03
Oprea1_644635
SPBio_001893
SPECTRUM1504268
Spectrum2_001677
Spectrum3_000998
Spectrum4_001126
Spectrum5_001466
Spectrum_001713
UNII-JMS50MPO89
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
losartan
losartan potassium
8HIV Protease InhibitorsPhase 45319
9Angiotensin-Converting Enzyme InhibitorsPhase 4711
10Antihypertensive AgentsPhase 44095
11Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 212767
12Diuretics, Potassium SparingPhase 4, Phase 31827
13Mineralocorticoid Receptor AntagonistsPhase 4, Phase 3333
14MineralocorticoidsPhase 4, Phase 3352
15Natriuretic AgentsPhase 4, Phase 31645
16Insulin, Globin ZincPhase 44523
17insulinPhase 44524
18Adrenergic AgentsPhase 4, Phase 3, Phase 25140
19HormonesPhase 4, Phase 3, Phase 213979
20
protease inhibitorsPhase 45320
Synonyms:
 
protease inhibitors
21diureticsPhase 4, Phase 31372
22Epinephryl boratePhase 4, Phase 3, Phase 2933
23Bronchodilator AgentsPhase 4, Phase 3, Phase 22856
24MydriaticsPhase 4, Phase 3, Phase 2763
25Neurotransmitter AgentsPhase 4, Phase 3, Phase 217734
26Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 222776
27Autonomic AgentsPhase 4, Phase 3, Phase 29774
28Anti-Asthmatic AgentsPhase 4, Phase 3, Phase 23369
29Hormone AntagonistsPhase 4, Phase 3, Phase 212778
30Adrenergic AgonistsPhase 4, Phase 3, Phase 22877
31Adrenergic alpha-AgonistsPhase 4, Phase 3, Phase 21625
32Adrenergic beta-AgonistsPhase 4, Phase 3, Phase 21640
33Respiratory System AgentsPhase 4, Phase 3, Phase 24818
34RacepinephrinePhase 4, Phase 3, Phase 2933
35Antiparkinson AgentsPhase 41527
36Dopamine agonistsPhase 4618
37Vasoconstrictor AgentsPhase 4, Phase 3, Phase 22027
38Dopamine AgentsPhase 43759
39Angiotensin Receptor AntagonistsPhase 41173
40CoagulantsPhase 41428
41
Angiotensin IIPhase 4116268521-88-0, 11128-99-7172198, 65143
Synonyms:
1-8-Angiotensin I
1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide
Ang II
Angiotensin 2
Angiotensin II (human)
 
Angiotensin II (mouse)
Angiotonin
Asp-arg-val-TYR-ile-his-pro-phe
Human angiotensin II
Hypertensin
Ile(5)-angiotensin II
42KallikreinsPhase 425
43Angiotensin II Type 1 Receptor BlockersPhase 41078
44AngiotensinogenPhase 41161
45Fertility AgentsPhase 4493
46Anti-Arrhythmia AgentsPhase 42969
47
Hydrocortisoneapproved, vet_approvedPhase 3, Phase 264050-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
48
Lidocaineapproved, vet_approvedPhase 2, Phase 31226137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
49AnestheticsPhase 2, Phase 39001
50Melanocyte-Stimulating HormonesPhase 3132

Interventional clinical trials:

(show all 43)
idNameStatusNCT IDPhase
1Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary AldosteronismUnknown statusNCT02127840Phase 4
2The Therapeutic Effect of Bromocriptin in Patients With Primary AldosteronismUnknown statusNCT00451672Phase 4
3Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary AldosteronismCompletedNCT00155064Phase 4
4Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic AdrenalectomyCompletedNCT01959711Phase 4
5Aldosterone Antagonism and Microvascular FunctionRecruitingNCT01887119Phase 4
6Aldosterone, Microvascular Function and Salt-sensitivityRecruitingNCT02068781Phase 4
7SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.CompletedNCT01096654Phase 3
8Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial HypertensionCompletedNCT00138944Phase 3
9Study of CS-3150 in Patients With Primary AldosteronismRecruitingNCT02885662Phase 3
10Dynamic Hormone Diagnostics in Endocrine DiseaseNot yet recruitingNCT02934399Phase 2, Phase 3
11Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary HyperaldosteronismCompletedNCT00732771Phase 2
12Metabolic Syndrome and Insulin Resistance in Primary AldosteronismUnknown statusNCT00173082
13Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or FibrillationUnknown statusNCT01267747
14Postoperative Cardiovascular Index Change of Primary AldosteronismUnknown statusNCT00746070
15Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin ActivityUnknown statusNCT00917345
16Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives.Unknown statusNCT00407784
17D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell ProliferationUnknown statusNCT00173446
18Anesthesia Management of Retroperitoneal AdrenalectomiesUnknown statusNCT00894335
19Optimizing Diagnosis Of Primary AldosteronismCompletedNCT02755519
20The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary AldosteronismCompletedNCT02216721
21Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and TreatmentCompletedNCT01728493
22Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in ChinaCompletedNCT01459042
23Intraoperative Analysis of Cortisol During Adrenal Vein SamplingCompletedNCT01761344
24Arterial Stiffness Index as a Predictor of Surgically Correctable Primary AldosteronismCompletedNCT01190501
25Study of Myocardial Interstitial Fibrosis in HyperaldosteronismCompletedNCT02938910
26Adrenal Vein Sampling International Study (AVIS Study)CompletedNCT01234220
27Etiology of Sleep Apnea-related Hyperaldosteronism - BP TreatmentCompletedNCT01897727
28Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood PressureCompletedNCT00001176
29Primary Aldosteronism in Western NorwayRecruitingNCT02832388
30Glucose Metabolism in Subjects With Aldosterone-Producing AdenomasRecruitingNCT02362308
31Renal Sympathetic Denervation From The Adventitia on HypertensionRecruitingNCT02642445
32Laparoscopic Adrenalectomy Versus Radiofrequency AblationRecruitingNCT02030587
33Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study)RecruitingNCT02804321
34Adrenal Tumors - Pathogenesis and TherapyRecruitingNCT00669266
35Omics Signature in the Diagnosis of HypertensionRecruitingNCT02772315
36The Role of Aldosterone on Augmented Exercise Pressor Reflex in HypertensionRecruitingNCT01996449
3711C-Metomidate PET Versus Adrenal Vein Sampling in Primary AldosteronismActive, not recruitingNCT01567111
38Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic AdrenalectomyActive, not recruitingNCT01676025
39Primary Hyperaldosteronism and Ischemia-reperfusion InjuryEnrolling by invitationNCT01978132
40Primary Aldosteronism in Malaysia: A Nationwide Multicentre StudyEnrolling by invitationNCT02257450
41Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary AldosteronismNot yet recruitingNCT02756754
42IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary HyperaldosteronismNot yet recruitingNCT02945904
43Microvascular Function in Primary AldosteronismWithdrawnNCT02096939

Search NIH Clinical Center for Conn's Syndrome

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: hyperaldosteronism

Genetic Tests for Conn's Syndrome

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Genetic tests related to Conn's Syndrome:

id Genetic test Affiliating Genes
1 Primary Hyperaldosteronism27

Anatomical Context for Conn's Syndrome

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MalaCards organs/tissues related to Conn's Syndrome:

36
Bone, Adrenal gland, Kidney, Cortex, Adrenal cortex, Testes, Skeletal muscle

Publications for Conn's Syndrome

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Articles related to Conn's Syndrome:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Clinical Case of the Month: PERSISTENT HYPERTENSION IN A YOUNG WOMAN: A CLASSIC PRESENTATION OF CONN'S SYNDROME. (26986864)
2016
2
Adrenal Vein Sampling for Conn's Syndrome: Diagnosis and Clinical Outcomes. (26854152)
2015
3
Aldosterone deficiency after unilateral adrenalectomy for Conn's syndrome: a case report and literature review. (25604311)
2015
4
Contralateral adrenal abnormalities in Conn's syndrome. (26237993)
2015
5
Cortex sparing laparoscopic adrenalectomy in a patient with Conn's syndrome. (25931842)
2013
6
Hypokalemia- induced myopathy and massive creatine kinase elevation as first manifestation of Conn's syndrome. (24249961)
2013
7
A case of Conn's syndrome presenting with painfull muscular weakness. (23715367)
2013
8
KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome. (22323562)
2012
9
Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report. (21980052)
2011
10
Aldosterone increases Na+ -K+ -ATPase activity in skeletal muscle of patients with Conn's syndrome. (21044117)
2011
11
Conn's syndrome unmasked by thiazide-induced hypokalaemia. (22041837)
2011
12
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. (20953222)
2010
13
A case of Conn's syndrome revealed after oral sodium phosphate (Fleet) preparation for colonoscopy. (20402838)
2010
14
Is hyperaldosteronism a pathognomonic feature of conn's syndrome? (23133229)
2010
15
Conn's syndrome. (19190201)
2009
16
Laparoscopic adrenalectomy for Conn's syndrome: report of the initial six cases. (20099423)
2009
17
Conn's syndrome]. (19099278)
2009
18
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. (18772856)
2008
19
Open adrenalectomy surgery: an obsolete technique? About a case of Conn's syndrome. (18572739)
2008
20
Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. (18543405)
2008
21
Retroperitoneoscopic adrenalectomy in Conn's syndrome caused by adrenal adenomas or nodular hyperplasia. (18343972)
2008
22
Delay in the diagnosis of Conn's syndrome: a single-center experience over 30 years. (18663152)
2008
23
Long-term results of endoscopic adrenalectomy for Conn's syndrome. (17305298)
2007
24
Lessons in the diagnosis and management of Conn's syndrome. (17990731)
2007
25
Conn's syndrome in pregnancy successfully treated with amiloride. (17999306)
2007
26
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. (17315030)
2007
27
Laparoscopic adrenalectomy for Conn's syndrome. (16441999)
2006
28
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
29
Association between Crohn's disease and Conn's syndrome. A report of two cases. (15985978)
2005
30
Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn's syndrome. (16222471)
2005
31
Conn's syndrome presenting as depression. (15930081)
2005
32
Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn's syndrome with an ominous clinical course. (15788646)
2005
33
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
34
Shift from Conn's syndrome to Cushing's syndrome in a recurrent adrenocortical carcinoma. (16260420)
2005
35
Conn's syndrome (primary hyperaldosteronism) simulating polymyositis. (15034751)
2005
36
Renal transplantation unveils Conn's syndrome: a case report. (15621124)
2004
37
Roentgenoendovascular treatment of Conn's syndrome. (15622394)
2004
38
Laparoscopic adrenalectomy for Conn's syndrome complicated by ipsilateral congenital pelvic kidney. (15791386)
2004
39
Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome). (15241622)
2004
40
Conn's syndrome associated with Behcet's disease. (12589107)
2003
41
CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. (12933492)
2003
42
Hypokalemic rhabdomyolysis aggravated by diuretics complicating Conn's syndrome without acute renal failure. (11837808)
2002
43
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). (11422106)
2001
44
Conn's syndrome and atrial fibrillation. (11421216)
2001
45
Outpatient laparoscopic adrenalectomy in patients with Conn's syndrome. (11591947)
2001
46
Conn's syndrome and bilateral renal artery stenosis in the presence of multiple renal arteries. (11383914)
2001
47
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. (11827421)
2001
48
Clinics in diagnostic imaging (39). Conn's syndrome due to adrenocortical adenoma (Conn's tumour). (10560278)
1999
49
Anaesthesia for Conn's syndrome. (10403872)
1999
50
Soft-tissue images. Adrenocortical adenocarcinoma presenting as Conn's syndrome. (10223065)
1999

Variations for Conn's Syndrome

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Expression for genes affiliated with Conn's Syndrome

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Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for genes affiliated with Conn's Syndrome

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GO Terms for genes affiliated with Conn's Syndrome

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Biological processes related to Conn's Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1aldosterone biosynthetic processGO:003234210.6CYP11B1, CYP11B2
2cellular response to potassium ionGO:003586510.6CYP11B1, CYP11B2
3cortisol biosynthetic processGO:003465110.6CYP11B1, CYP11B2
4mineralocorticoid biosynthetic processGO:000670510.4CYP11B2, CYP21A2
5steroid biosynthetic processGO:000669410.2CYP17A1, CYP21A2
6C21-steroid hormone biosynthetic processGO:000670010.1CYP11A1, CYP11B1, CYP11B2
7cellular response to peptide hormone stimulusGO:007137510.1CYP11A1, CYP11B1, CYP11B2
8cholesterol metabolic processGO:000820310.1CYP11A1, CYP11B1, CYP11B2
9renin-angiotensin regulation of aldosterone productionGO:000201810.0AGTR1, REN
10steroid metabolic processGO:000820210.0CYP17A1, CYP21A2
11secondary metabolite biosynthetic processGO:00445509.9CYP11A1, CYP11B1, CYP11B2
12regulation of blood pressureGO:00082179.6CYP11B1, NPPA, POMC, REN
13glucocorticoid biosynthetic processGO:00067049.5CYP11A1, CYP11B1, CYP17A1, CYP21A2
14oxidation-reduction processGO:00551149.1CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2
15sterol metabolic processGO:00161258.5CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2

Molecular functions related to Conn's Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1corticosterone 18-monooxygenase activityGO:004778310.5CYP11B1, CYP11B2
2steroid 11-beta-monooxygenase activityGO:000450710.3CYP11B1, CYP11B2
3steroid bindingGO:000549610.1CYP21A2, NR3C2
4neuropeptide hormone activityGO:000518410.1NPPA, POMC
5oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenGO:00167099.8CYP11A1, CYP11B1, CYP11B2
6steroid hydroxylase activityGO:00083959.7CYP11B2, CYP21A2
7heme bindingGO:00200379.1CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2
8iron ion bindingGO:00055069.0CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2

Sources for Conn's Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet