MCID: CNN003
MIFTS: 47

Conn's Syndrome malady

Rare diseases, Cancer diseases categories

Summaries for Conn's Syndrome

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 An adrenal admenoma characterized by over production of aldosterone.

MalaCards: Conn's Syndrome, also known as primary hyperaldosteronism, is related to hyperaldosteronism and hypertension. An important gene associated with Conn's Syndrome is REN (renin), and among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds 18-hydroxycorticosterone and benazepril have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and cortex, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Conn's Syndrome

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

conn's syndrome 9 44
primary hyperaldosteronism 9 44
primary aldosteronism 9 44
primary aldosteronism, hypokalemic alkalosis, hypertension and muscle weakness 44
aldosteronism primary 46
conns syndrome 11
conn syndrome 9


External Ids:

Disease Ontology9 DOID:12028
ICD9CM28 255.12
NCIt41 C34510
MeSH36 D006929

Related Diseases for Conn's Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1hyperaldosteronism31.7CYP11B2, KCNJ5, REN, NR3C2
2hypertension31.2NR3C2, REN, CYP11B2
3adenoma30.8CYP11B2, KCNJ5, INHA, REN, NR3C2
4adrenal adenoma30.7REN, INHA
5low renin hypertension30.7REN, CYP11B2
6essential hypertension30.7CYP11B2, REN, NR3C2
7hypokalemia30.6CYP11B2, REN, NR3C2
8cushing's syndrome30.5REN, CYP11B2
9adrenocortical carcinoma30.3INHA, CYP11B2
10hypoaldosteronism30.3CYP11B2, REN
11glucocorticoid-remediable aldosteronism30.1NR3C2, REN, CYP11B2
12diabetes mellitus30.0NR3C2, REN, KCNJ5
13proteinuria30.0NR3C2, REN, CYP11B2
14myocardial infarction29.9CYP11B2, KCNJ5, REN, NR3C2
15malignant hypertension10.4
16familial hyperaldosteronism10.4
17primary hyperparathyroidism10.3
18hyperparathyroidism10.3
19myopathy10.3
20thyroiditis10.2
21kidney disease10.2
22hyperaldosteronism, familial, type iii10.2
23renovascular hypertension10.2
24nephrocalcinosis10.2
25adrenal carcinoma10.2
26primary aldosteronism, seizures, and neurologic abnormalities10.2
27polycystic kidney disease10.1
28twin-to-twin transfusion syndrome10.1
29familial partial lipodystrophy10.1
30vitiligo10.1
31hypokalemic periodic paralysis10.1
32artery disease10.1
33hepatitis10.1
34hypothyroidism10.1
35lipodystrophy10.1
36peritonitis10.1
37renal artery disease10.1
38familial hyperaldosteronism type 210.1
39glucagonoma10.1
40polymyositis10.1
41pseudohypoaldosteronism type ii10.0REN, NR3C2
42pseudohypoaldosteronism10.0NR3C2, REN
43congenital adrenal hyperplasia10.0CYP11B2, REN
44renal fibrosis10.0REN, NR3C2
45addison's disease10.0REN, CYP11B2
46metabolic acidosis10.0NR3C2, REN
47gynecomastia10.0INHA, NR3C2
48diabetic nephropathy10.0NR3C2, REN
49polycystic ovary syndrome10.0NR3C2, INHA
50wilms tumor10.0INHA, REN

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Symptoms for Conn's Syndrome

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Drugs & Therapeutics for Conn's Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Conn's Syndrome

Drug clinical trials:

Search ClinicalTrials for Conn's Syndrome

Search NIH Clinical Center for Conn's Syndrome

Search CenterWatch for Conn's Syndrome

Genetic Tests for Conn's Syndrome

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Anatomical Context for Conn's Syndrome

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Sources:
34MalaCards
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MalaCards organs/tissues related to Conn's Syndrome:

34
Kidney, Adrenal gland, Cortex, Skeletal muscle, Testes, Adrenal cortex

Animal Models for Conn's Syndrome or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Conn's Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.0NR3C2, REN, CYP11B2
2MP:00053678.9CYP11B2, REN, NR3C2
3MP:00053788.4CYP11B2, INHA, REN, NR3C2
4MP:00053768.1NR3C2, REN, INHA, CYP11B2
5MP:00053857.6NR3C2, REN, INHA, KCNJ5, CYP11B2

Publications for Conn's Syndrome

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Sources:
53PubMed
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Articles related to Conn's Syndrome:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. (20953222)
2010
2
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. (18772856)
2008
3
Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. (18543405)
2008
4
Lessons in the diagnosis and management of Conn's syndrome. (17990731)
2007
5
Conn's syndrome in pregnancy successfully treated with amiloride. (17999306)
2007
6
Long-term results of endoscopic adrenalectomy for Conn's syndrome. (17305298)
2007
7
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. (17315030)
2007
8
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
9
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
10
Association between Crohn's disease and Conn's syndrome. A report of two cases. (15985978)
2005
11
Roentgenoendovascular treatment of Conn's syndrome. (15622394)
2004
12
Laparoscopic adrenalectomy for Conn's syndrome complicated by ipsilateral congenital pelvic kidney. (15791386)
2004
13
Conn's syndrome associated with Behcet's disease. (12589107)
2003
14
CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. (12933492)
2003
15
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). (11422106)
2001
16
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. (11827421)
2001
17
Clinics in diagnostic imaging (39). Conn's syndrome due to adrenocortical adenoma (Conn's tumour). (10560278)
1999
18
Conn's syndrome: a simple diagnostic approach. (10613001)
1999
19
Anaesthesia for Conn's syndrome. (10403872)
1999
20
Calcium-channel blockade can mask the diagnosis of Conn's syndrome. (10715768)
1999
21
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes. (9863625)
1998
22
Primary aldosteronism (Conn's syndrome). (8530580)
1995
23
Refractory hypertension due to Conn's syndrome. (8121854)
1994
24
Altered primary haemostasis in Conn's syndrome. (1448795)
1992
25
Conn's syndrome. (2246200)
1990
26
Conn's syndrome with rhabdomyolysis mimicking deep vein thrombophlebitis. (2315785)
1990
27
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988
28
Pheochromocytoma and Conn's syndrome in Denmark 1977-1981. (3472432)
1986
29
Quantitative selenium-75-cholesterol imaging and computed tomography of the adrenal glands in Conn's syndrome. (7135126)
1982
30
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. (7014043)
1981
31
Conn's syndrome in a patient with acromegaly. (7016705)
1981
32
Primary hyperparathyroidism in a patient with Conn's syndrome. (7383950)
1980
33
The structure of the juxtaglomerular apparatus in Addison's disease, Bartter's syndrome, and in Conn's syndrome: a comparative, morphometric, light microscopic study on serial secions. (818792)
1976
34
Nursing care study: Conn's syndrome. (1044099)
1976
35
Conn's syndrome. (4699809)
1973
36
Urinary excretion of tetrahydroaldosterone in normal subjects and in patients with adrenal insufficiency and Conn's syndrome. (4678197)
1972
37
The diagnosis of primary aldosteronism (Conn's syndrome). (A case report). (5025979)
1972
38
Studies on the biosynthesis of aldosterone in solitary adenoma and in nodular hyperplasia of the adrenal cortex in patients exhibiting Conn's syndrome. (5395005)
1969
39
Renal mastocytosis in a case of Conn's syndrome. (5602588)
1967
40
The aldosterone-renin constellation in Conn's syndrome. (4294143)
1967
41
Conn's syndrome. A detailed study on corticoid metabolites in the urine in two operated cases. (5908976)
1966
42
HYPOKALEMIC ALKALOSIS WITH ADRENAL TUMOR: A CASE REPORT. CONN'S SYNDROME OR DRUG-INDUCED HYPOKALEMIC ALKALOSIS. (14256705)
1965
43
CONN'S SYNDROME WITH ASSOCIATED PREGNANCY. (14341826)
1965
44
PLASMA RENIN IN A CASE OF CONN'S SYNDROME WITH FIBRINOID LESIONS: USE OF SPINONOLACTONE IN TREATMENT. (14213078)
1964
45
CATHETERIZATION OF THE LEFT ADRENAL VEIN FOR CONTRAST INJECTION AND STEROID ANALYSIS IN A CASE OF CONN'S SYNDROME. (14213891)
1964
46
CONN'S SYNDROME. (14077792)
1963
47
Modification of the effects of aldosterone on electrolyte excretion in man by simultaneous administration of corticosterone and hydrocortisone. Relevance to Conn's syndrome. (13854575)
1960
48
Conn's syndrome. (13591287)
1958
49
Conn's syndrome with severe hypertension. (13287082)
1956
50
Experimental production of morphological changes resembling Conn's syndrome. (13377711)
1956

Variations for Conn's Syndrome

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Expression for genes affiliated with Conn's Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conn's Syndrome

Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for genes affiliated with Conn's Syndrome

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG
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Pathways related to Conn's Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4REN, INHA
2
Show member pathways
9.0NR3C2, REN, CYP11B2

Compounds for genes affiliated with Conn's Syndrome

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Conn's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone46 2510.9REN, CYP11B2
2benazepril46 52 1211.9REN, CYP11B2
3glycyrrhetinic acid46 2510.8REN, NR3C2
4drospirenone46 30 52 1212.8REN, NR3C2
5Cortexolone259.8CYP11B2, NR3C2
6deoxycorticosterone30 2510.8NR3C2, CYP11B2
7glycyrrhizin46 3010.8NR3C2, REN
8hydralazine46 52 1211.8CYP11B2, REN
9cortisol30 2510.8NR3C2, CYP11B2
10thiazide469.8REN, NR3C2
11atenolol46 52 30 25 1213.8REN, CYP11B2
12irbesartan46 30 52 1212.8CYP11B2, REN
13aldosterone30 25 1211.8NR3C2, CYP11B2
14felodipine46 30 1211.7NR3C2, REN
15metyrapone46 62 1211.7CYP11B2, NR3C2
16metoclopramide46 52 1211.7CYP11B2, REN
1717-hydroxyprogesterone46 2510.7REN, CYP11B2
18cortisone46 2510.7NR3C2, CYP11B2
19candesartan46 52 30 1212.6CYP11B2, REN
20carbenoxolone46 30 1211.6REN, NR3C2
21enalapril46 52 1211.6REN, NR3C2
22tetrahydroaldosterone469.4CYP11B2, REN, NR3C2
23fludrocortisone46 30 1211.4NR3C2, REN, CYP11B2
24eplerenone46 62 30 1212.4CYP11B2, REN, NR3C2
2511 deoxycortisol469.4REN, NR3C2, CYP11B2
26doca469.4NR3C2, CYP11B2, REN
27hydrochlorothiazide46 30 52 25 1213.4CYP11B2, NR3C2, REN
28spironolactone46 62 30 52 1213.4CYP11B2, REN, NR3C2
2911beta-hydroxysteroid469.4CYP11B2, NR3C2, REN
30ang ii469.4REN, CYP11B2, NR3C2
31losartan46 52 30 1212.4NR3C2, CYP11B2, REN
32corticosterone46 62 2511.4NR3C2, CYP11B2, REN
33hydrocortisone46 3 62 1212.4CYP11B2, REN, NR3C2
34androstenedione46 2510.3INHA, REN, CYP11B2
353beta-hydroxysteroid469.2INHA, CYP11B2, NR3C2
36ribonucleic acid469.1INHA, CYP11B2, NR3C2
37nifedipine46 30 52 1212.0CYP11B2, KCNJ5, REN
38estradiol46 25 1210.9NR3C2, REN, INHA
39acth468.8CYP11B2, INHA, REN, NR3C2
40forskolin46 52 1210.8INHA, REN, CYP11B2
41steroid468.7REN, CYP11B2, NR3C2, INHA
42dopamine46 30 25 1211.7REN, KCNJ5, NR3C2
43haloperidol46 52 30 3 1212.6KCNJ5, REN, NR3C2, CYP11B2
44norepinephrine46 25 1210.6NR3C2, REN, KCNJ5, CYP11B2
45potassium46 25 1210.6NR3C2, REN, KCNJ5, CYP11B2
46sodium46 259.6NR3C2, REN, CYP11B2, KCNJ5
47nitric oxide46 25 1210.5CYP11B2, REN, KCNJ5, NR3C2
48glucose468.5REN, NR3C2, KCNJ5, CYP11B2
49testosterone46 62 25 1211.4NR3C2, INHA, KCNJ5, CYP11B2
50lysine468.3NR3C2, KCNJ5, CYP11B2

GO Terms for genes affiliated with Conn's Syndrome

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17Gene Ontology
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Biological processes related to Conn's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1male gonad developmentGO:0085849.4REN, INHA

Products for genes affiliated with Conn's Syndrome

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  • Antibodies
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Sources for Conn's Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet