MCID: CNN003
MIFTS: 52

Conn's Syndrome malady

Summaries for Conn's Syndrome

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An adrenal admenoma characterized by over production of aldosterone.

MalaCards: Conn's Syndrome, also known as primary hyperaldosteronism, is related to adenoma and adrenal adenoma. An important gene associated with Conn's Syndrome is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are Renin-angiotensin system and Endogenous sterols. The compounds saralasin and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are muscle and mortality/aging.

Aliases & Classifications for Conn's Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 57SNOMED-CT, 61UMLS, 27ICD9CM, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

conn's syndrome 8 43
primary hyperaldosteronism 8 43
primary aldosteronism 8 43
primary aldosteronism, hypokalemic alkalosis, hypertension and muscle weakness 43
aldosteronism primary 45
conns syndrome 10


External Ids:

Disease Ontology8 DOID:12028
ICD9CM27 255.12
NCIt40 C34510
MeSH35 D006929

Related Diseases for Conn's Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.0KCNJ5, NR3C2, AGTR2, POMC, CYP11B1, CYP11B2
2adrenal adenoma30.8AGTR1, POMC, CYP11B1, REN, INHA
3cushing's syndrome30.5POMC, NR3C2
4hypokalemia30.4NR3C2, POMC, CYP11B2, REN
5adrenocortical carcinoma30.3AGTR1, POMC, CYP11B1, CYP11B2, INHA
6renovascular hypertension30.2REN, AGTR1, NPPA
7hypoaldosteronism30.2REN, CYP11B2, POMC
8thyroiditis29.9POMC
9hyperandrogenism29.9HSD3B1, POMC
10glucocorticoid-remediable aldosteronism29.9NR3C2, POMC, CYP11B1, CYP11B2, REN
11primary unilateral adrenal hyperplasia10.3
12primary hyperparathyroidism10.3
13familial hyperaldosteronism10.3
14nephrocalcinosis10.1
15adrenal carcinoma10.1
16n syndrome10.1
17primary aldosteronism, seizures, and neurologic abnormalities10.1
18familial partial lipodystrophy10.0
19polycystic kidney disease10.0
20hypokalemic periodic paralysis10.0
21vitiligo10.0
22autosomal dominant disease10.0
23polycystic kidney disease, autosomal dominant10.0
24bod syndrome10.0
25twin twin transfusion syndrome10.0
26glucagonoma10.0
27hypothyroidism, autoimmune10.0
28peritoneal carcinoma10.0
29primary peritoneal carcinoma10.0
30benign essential hypertension10.0
31klinefelter's syndrome10.0
32gitelman syndrome10.0
33fatty liver disease10.0
34hypertensive encephalopathy10.0
35nephrolithiasis10.0
36dissecting aortic aneurysm10.0
37phaeochromocytoma10.0
38aortic aneurysm10.0
39thyroid cancer10.0
40medullary sponge kidney10.0
41polymyositis10.0
42thyrotoxic periodic paralysis10.0
43myocardial stunning10.0KCNJ5
44coronary heart disease10.0AGTR1
45cerebrovascular disease10.0AGTR1
46mitral valve prolapse10.0AGTR1
47ureteral obstruction10.0AGTR1
48fibromuscular dysplasia10.0REN
49glomerulonephritis10.0AGTR1
50inappropriate adh syndrome10.0NPPA

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Clinical Features for Conn's Syndrome

Drugs & Therapeutics for Conn's Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Conn's Syndrome

Drug clinical trials:

Search ClinicalTrials for Conn's Syndrome

Search NIH Clinical Center for Conn's Syndrome

Search CenterWatch for Conn's Syndrome

Genetic Tests for Conn's Syndrome

Anatomical Context for Conn's Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Conn's Syndrome:

33
Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Colon, Adipocyte, Kidney, Liver, Lung, Adrenal gland, Skin, Ovary, T cells, B cells, Amygdala, Atrioventricular node, Adrenal cortex

Animal Models for Conn's Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Conn's Syndrome

Sources:
51PubMed
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Articles related to Conn's Syndrome:

(show top 50)    (show all 375)
idTitleAuthorsYear
1
Severe eczema and Hyper-IgE in Loeys-Dietz-syndrome - Contribution to new findings of immune dysregulation in connective tissue disorders. (24333532)
2014
2
Congenital long QT syndrome of particularly malignant course connected with so far unknown mutation in the sodium channel SCN5A gene. (23558814)
2013
3
Sagging eye syndrome: connective tissue involution as a cause of horizontal and vertical strabismus in older patients. (23471194)
2013
4
Silica-associated connective tissue syndrome with acquired hemophilia (Factor VIII inhibitor), presenting with life-threatening bleed. (24289663)
2013
5
Overlap connective tissue disease syndromes. (22743033)
2013
6
Idiopathic mediastinal fibrosis presenting with antiphospholipid antibody syndrome and manifestations suggestive of connective tissue disease. (22426588)
2012
7
Metabolic and functional connectivity changes in mal de debarquement syndrome. (23209584)
2012
8
Hypoplastic left heart syndrome and aortic atresia-mitral stenosis variant: role of myocardial protection strategy and impact of ventriculo-coronary connections after stage I palliation. (21644013)
2011
9
A case of Conn's syndrome revealed after oral sodium phosphate (Fleet) preparation for colonoscopy. (20402838)
2010
10
Glucose transporter 10 and arterial tortuosity syndrome: the vitamin C connection. (20547159)
2010
11
Lissencephaly, IgG subclass immunodeficiency, and a connective tissue disorder: a new syndrome? (19768484)
2009
12
Retrosternal compression seven years after surgical correction of partial anomalous pulmonary venous connection: Scimitar syndrome. (18482388)
2009
13
Partial anomalous pulmonary venous connection associated with Lutembacher's syndrome. (18177387)
2008
14
Importance of totally anomalous pulmonary venous connection and postoperative pulmonary vein stenosis in outcomes of heterotaxy syndrome. (18004616)
2008
15
Connexin 26 mutation in keratitis-ichthyosis-deafness (KID) syndrome in mother and daughter with combined conductive and sensorineural hearing loss. (18412859)
2008
16
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. (18772856)
2008
17
Potocki-Lupski syndrome mimicking a connective tissue disorder. (18541972)
2008
18
Malignant intracranial germinoma in Smith-Lemli-Opitz syndrome: cholesterol homeostasis possibly connecting morphogenesis and cancer development. (18776762)
2008
19
Mirizzi syndrome in a patient with anomalous connection of the cystic duct into the right hepatic duct. (18050827)
2007
20
Long-term results of endoscopic adrenalectomy for Conn's syndrome. (17305298)
2007
21
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. (17315030)
2007
22
Trp207Gly in platelet glycoprotein Ibalpha is a novel mutation that disrupts the connection between the leucine-rich repeat domain and the disulfide loop structure and causes Bernard-Soulier syndrome. (17083647)
2007
23
Reversible posterior leucoencephalopathy syndrome in a patient with undifferentiated connective tissue disease. (16766377)
2006
24
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
25
Cochleosaccular dysplasia associated with a connexin 26 mutation in keratitis-ichthyosis-deafness syndrome. (16885744)
2006
26
G59S mutation in the GJB2 (connexin 26) gene in a patient with Bart- Pumphrey syndrome. (15952212)
2005
27
Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn's syndrome. (16222471)
2005
28
Surgical management of an extracardiac total cavopulmonary connection in heterotaxy syndrome with isolated hepatic drainage. (15875102)
2005
29
Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome. (15665347)
2005
30
Ullrich congenital muscular dystrophy: connective tissue abnormalities in the skin support overlap with Ehlers-Danlos syndromes. (15690374)
2005
31
Clinical significance of antinuclear antibodies in malignant diseases: association with rheumatic and connective tissue paraneoplastic syndromes. (15119543)
2004
32
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. (12724401)
2003
33
Superior vena cava-left atrial connection for Eisenmenger syndrome. (11547329)
2001
34
Atrial double potentials associated with the elimination of the electrical connection between the coronary sinus (CS) and the left atrium in two cases of Wolff-Parkinson-White syndrome with a CS-connected accessory pathway. (11059623)
2000
35
Calcium-channel blockade can mask the diagnosis of Conn's syndrome. (10715768)
1999
36
Soft-tissue images. Adrenocortical adenocarcinoma presenting as Conn's syndrome. (10223065)
1999
37
Prevalence of adrenal and extra-adrenal Conn syndrome in hypertensive patients. (8639013)
1996
38
The association of myasthenia gravis and connective tissue diseases--the role of SjA,gren's syndrome. (8144128)
1994
39
Association of mixed connective tissue disease, SjAPgren's syndrome and autoimmune hepatitis: report of a case. (1920970)
1991
40
Clinical and serologic characteristics of patients with overlap syndrome: is mixed connective tissue disease a distinct clinical entity? (2642587)
1989
41
Surgical management of primary aldosteronism (Conn's syndrome), a correctable cause of hypertension. (6598066)
1984
42
Quantitative selenium-75-cholesterol imaging and computed tomography of the adrenal glands in Conn's syndrome. (7135126)
1982
43
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. (7014043)
1981
44
The Winchester syndrome: a nonlysosomal connective tissue disease. (4206841)
1974
45
Urinary excretion of tetrahydroaldosterone in normal subjects and in patients with adrenal insufficiency and Conn's syndrome. (4678197)
1972
46
The diagnosis of primary aldosteronism (Conn's syndrome). (A case report). (5025979)
1972
47
Primary aldosteronism--Conn's syndrome (a case report). (4658679)
1972
48
Intrapulmonary segment in anomalous pulmonary venous connection. Resemblance to scimitar syndrome. (6026204)
1967
49
Modification of the effects of aldosterone on electrolyte excretion in man by simultaneous administration of corticosterone and hydrocortisone. Relevance to Conn's syndrome. (13854575)
1960
50
Conn's syndrome: the effect of amphenone. (14402326)
1960

Genetic Variations for Conn's Syndrome

Expression for genes affiliated with Conn's Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conn's Syndrome

Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for genes affiliated with Conn's Syndrome

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Compounds for genes affiliated with Conn's Syndrome

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Conn's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1saralasin459.6REN, AGTR1, AGTR2
2cyclosporin a45 29 6011.6KCNJ5, NR3C2
3tetrahydroaldosterone459.6REN, CYP11B2, NR3C2
4irbesartan45 29 50 1112.5AGTR1, CYP11B2, AGTR2, REN
5metoclopramide45 1110.3REN, NPPA, CYP11B2, CYP11B1
6benazepril45 1110.3NPPA, AGTR1, REN
721-deoxycortisol45 2410.3POMC, CYP11B2, CYP11B1
8enalapril45 50 1111.3REN, AGTR2, NPPA, AGTR1
9deoxycorticosterone29 2410.2HSD3B1, NR3C2, CYP11B2, CYP11B1
10trandolapril45 1110.2NPPA, AGTR1, REN
11eplerenone45 60 29 1112.2REN, AGTR1, NR3C2, CYP11B2
12nitroglycerin45 1110.2NPPA, AGTR1, REN, KCNJ5
13aldosterone29 11 2411.2CYP11B2, CYP11B1, NR3C2, AGTR1
14hydrochlorothiazide45 50 29 11 2413.1REN, AGTR1, NR3C2, CYP11B2
1518-hydroxycorticosterone45 2410.1POMC, CYP11B2, REN, CYP11B1
16etomidate45 1110.1POMC, CYP11B2, CYP11B1
17felodipine45 29 1110.9AGTR1, REN, NR3C2, NPPA
18cilazapril45 119.9REN, AGTR1, NPPA
19cgmp45 299.9AGTR2, AGTR1, NPPA, KCNJ5, REN
20nifedipine45 50 29 1111.9CYP11B2, AGTR1, KCNJ5, REN, NPPA
21captopril45 29 50 60 1112.7AGTR2, AGTR1, REN, NR3C2, NPPA
2217-hydroxyprogesterone45 249.7CYP11B1, POMC, REN, HSD3B1, CYP11B2
23metyrapone60 45 1110.7CYP11B1, NR3C2, POMC, CYP11B2
24furosemide45 50 60 29 11 2413.6POMC, AGTR1, NPPA, REN
25prostaglandin458.6KCNJ5, AGTR2, AGTR1, REN, NPPA
2611 deoxycortisol458.5REN, CYP11B2, CYP11B1, NR3C2, POMC
27doca458.5NR3C2, POMC, CYP11B1, CYP11B2, REN
28ang ii458.5REN, CYP11B2, AGTR1, AGTR2, NR3C2, NPPA
29losartan45 50 29 1111.5AGTR1, CYP11B2, NR3C2, NPPA, REN, AGTR2
30cortisol29 249.5POMC, CYP11B2, HSD3B1, NR3C2, CYP11B1
31androstenedione45 249.4INHA, REN, POMC, CYP11B2, HSD3B1, CYP11B1
32cortisone45 249.4CYP11B2, POMC, AGTR1, CYP11B1, NR3C2
33corticosterone45 60 2410.4REN, CYP11B1, NR3C2, POMC, CYP11B2
34hydrocortisone45 2 60 1111.3REN, CYP11B1, POMC, NR3C2, CYP11B2
35fludrocortisone45 29 1110.3REN, CYP11B2, POMC, NR3C2, NPPA
363beta-hydroxysteroid458.2POMC, NR3C2, HSD3B1, CYP11B1, CYP11B2, INHA
37forskolin45 50 1110.1CYP11B2, CYP11B1, POMC, REN, AGTR1, NPPA
3811beta-hydroxysteroid458.1REN, CYP11B1, POMC, AGTR1, NR3C2, CYP11B2
39potassium45 11 2410.1AGTR1, REN, KCNJ5, NPPA, NR3C2, CYP11B1
40catecholamine457.9NR3C2, AGTR2, AGTR1, POMC, REN, NPPA
41estradiol45 11 249.8NR3C2, POMC, CYP11B1, INHA, REN, AGTR1
42sodium45 248.8KCNJ5, CYP11B2, NPPA, REN, NR3C2, CYP11B1
43haloperidol45 29 2 50 1111.7POMC, NPPA, CYP11B2, REN, AGTR1, KCNJ5
44oxygen45 248.6NR3C2, NPPA, CYP11B2, ASPH, KCNJ5, CYP11B1
45norepinephrine45 11 249.4POMC, REN, CYP11B2, AGTR1, NPPA, AGTR2
46spironolactone50 45 60 29 1111.3NPPA, POMC, REN, CYP11B2, CYP11B1, AGTR1
47testosterone45 60 11 2410.3POMC, NR3C2, INHA, KCNJ5, HSD3B1, CYP11B1
48acth457.3POMC, AGTR1, CYP11B1, CYP11B2, REN, INHA
49steroid457.3POMC, CYP11B1, CYP11B2, REN, INHA, HSD3B1
50arginine457.2REN, NPPA, CYP11B2, POMC, CYP11B1, AGTR1

GO Terms for genes affiliated with Conn's Syndrome

Sources:
16Gene Ontology
See all sources

Biological processes related to Conn's Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cortisol biosynthetic processGO:03465110.0CYP11B1, CYP11B2
2aldosterone biosynthetic processGO:03234210.0CYP11B2, CYP11B1
3cellular response to potassium ionGO:0358659.9CYP11B2, CYP11B1
4C21-steroid hormone biosynthetic processGO:0067009.9CYP11B2, CYP11B1
5cellular response to hormone stimulusGO:0328709.8CYP11B1, CYP11B2
6glucocorticoid biosynthetic processGO:0067049.8HSD3B1, CYP11B1
7sterol metabolic processGO:0161259.7CYP11B1, CYP11B2
8renin-angiotensin regulation of aldosterone productionGO:0020189.7REN, AGTR2, AGTR1
9mineralocorticoid biosynthetic processGO:0067059.7CYP11B2, CYP11B1, HSD3B1
10steroid metabolic processGO:0082029.6HSD3B1, CYP11B1, CYP11B2
11steroid biosynthetic processGO:0066949.3TRERF1, HSD3B1
12regulation of blood pressureGO:0082178.5REN, NPPA, AGTR2, POMC, CYP11B1

Molecular functions related to Conn's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:0045079.9CYP11B2, CYP11B1
2angiotensin type II receptor activityGO:0049459.8AGTR1, AGTR2
3electron carrier activityGO:0090559.4ASPH, CYP11B2, CYP11B1
4hormone activityGO:0051798.5INHA, POMC, NPPA
5receptor bindingGO:0051028.4NPPA, POMC, REN, INHA

Products for genes affiliated with Conn's Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Conn's Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet