MCID: CNN003
MIFTS: 48

Conn's Syndrome malady

Rare diseases, Cancer diseases categories
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Summaries for Conn's Syndrome

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Disease Ontology:8 An adrenal admenoma characterized by over production of aldosterone.

MalaCards based summary: Conn's Syndrome, also known as primary hyperaldosteronism, is related to adrenal adenoma and hypertension. An important gene associated with Conn's Syndrome is REN (renin), and among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds 18-hydroxycorticosterone and benazepril have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and cortex, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Conn's Syndrome

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Conn's Syndrome, Aliases & Descriptions:

Name: Conn's Syndrome 8 42
Primary Hyperaldosteronism 8 42 62
Primary Aldosteronism 8 42 62
Conns Syndrome 10 62
 
Conn Syndrome 8 62
Primary Aldosteronism, Hypokalemic Alkalosis, Hypertension and Muscle Weakness 42
Aldosteronism Primary 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:12028
MeSH34 D006929
NCIt39 C34510
ICD9CM27 255.12

Related Diseases for Conn's Syndrome

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Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1adrenal adenoma31.2REN, CYP11B2
2hypertension31.2NR3C2, REN, CYP11B2
3low renin hypertension30.9REN, CYP11B2
4essential hypertension30.8CYP11B2, REN, NR3C2
5cushing's syndrome30.8REN, CYP11B2
6hypoaldosteronism30.6CYP11B2, REN
7hypokalemia30.5CYP11B2, REN, NR3C2
8adrenocortical carcinoma30.5INHA, CYP11B2
9hyperaldosteronism30.2CYP11B2, KCNJ5, REN, NR3C2
10adrenal cortical adenoma30.2REN, INHA
11adenoma30.2CYP11B2, KCNJ5, INHA, REN, NR3C2
12glucocorticoid-remediable aldosteronism30.0NR3C2, REN, CYP11B2
13proteinuria30.0NR3C2, REN, CYP11B2
14diabetes mellitus29.8NR3C2, REN, KCNJ5
15myocardial infarction29.5CYP11B2, KCNJ5, REN, NR3C2
16malignant hypertension10.4
17familial hyperaldosteronism10.4
18primary hyperparathyroidism10.3
19hyperparathyroidism10.3
20myopathy10.3
21adrenal carcinoma10.3
22thyroiditis10.3
23pseudohypoaldosteronism type ii10.2REN, NR3C2
24pseudohypoaldosteronism10.2NR3C2, REN
25congenital adrenal hyperplasia10.2CYP11B2, REN
26renal fibrosis10.2REN, NR3C2
27addison's disease10.2REN, CYP11B2
28renovascular hypertension10.2
29nephrocalcinosis10.2
30primary aldosteronism, seizures, and neurologic abnormalities10.2
31metabolic acidosis10.2NR3C2, REN
32gynecomastia10.1INHA, NR3C2
33diabetic nephropathy10.1NR3C2, REN
34polycystic ovary syndrome10.1NR3C2, INHA
35hepatitis10.1
36vitiligo10.1
37hypokalemic periodic paralysis10.1
38polycystic kidney disease10.1
39twin-to-twin transfusion syndrome10.1
40familial partial lipodystrophy10.1
41artery disease10.1
42hypothyroidism10.1
43lipodystrophy10.1
44peritonitis10.1
45renal artery disease10.1
46familial hyperaldosteronism type 210.1
47glucagonoma10.1
48wilms tumor10.1INHA, REN
49primary hyperoxaluria10.0NR3C2, REN
50sudden cardiac death multi-gene panels10.0KCNJ5, NR3C2

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Symptoms for Conn's Syndrome

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Drugs & Therapeutics for Conn's Syndrome

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Drug clinical trials:

Search ClinicalTrials for Conn's Syndrome

Search NIH Clinical Center for Conn's Syndrome

Genetic Tests for Conn's Syndrome

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Anatomical Context for Conn's Syndrome

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MalaCards organs/tissues related to Conn's Syndrome:

32
Kidney, Adrenal gland, Cortex, Skeletal muscle, Testes, Adrenal cortex

Animal Models for Conn's Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Conn's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.0NR3C2, REN, CYP11B2
2MP:00053678.9CYP11B2, REN, NR3C2
3MP:00053788.4CYP11B2, INHA, REN, NR3C2
4MP:00053768.1NR3C2, REN, INHA, CYP11B2
5MP:00053857.6NR3C2, REN, INHA, KCNJ5, CYP11B2

Publications for Conn's Syndrome

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Articles related to Conn's Syndrome:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. (20953222)
2010
2
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. (18772856)
2008
3
Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. (18543405)
2008
4
Lessons in the diagnosis and management of Conn's syndrome. (17990731)
2007
5
Conn's syndrome in pregnancy successfully treated with amiloride. (17999306)
2007
6
Long-term results of endoscopic adrenalectomy for Conn's syndrome. (17305298)
2007
7
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. (17315030)
2007
8
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
9
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
10
Association between Crohn's disease and Conn's syndrome. A report of two cases. (15985978)
2005
11
Roentgenoendovascular treatment of Conn's syndrome. (15622394)
2004
12
Laparoscopic adrenalectomy for Conn's syndrome complicated by ipsilateral congenital pelvic kidney. (15791386)
2004
13
Conn's syndrome associated with Behcet's disease. (12589107)
2003
14
CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. (12933492)
2003
15
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). (11422106)
2001
16
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. (11827421)
2001
17
Clinics in diagnostic imaging (39). Conn's syndrome due to adrenocortical adenoma (Conn's tumour). (10560278)
1999
18
Conn's syndrome: a simple diagnostic approach. (10613001)
1999
19
Anaesthesia for Conn's syndrome. (10403872)
1999
20
Calcium-channel blockade can mask the diagnosis of Conn's syndrome. (10715768)
1999
21
Primary aldosteronism (Conn's syndrome). (8530580)
1995
22
Refractory hypertension due to Conn's syndrome. (8121854)
1994
23
Altered primary haemostasis in Conn's syndrome. (1448795)
1992
24
Conn's syndrome can cause malignant hypertension. (1583635)
1992
25
Conn's syndrome. (2246200)
1990
26
Conn's syndrome with rhabdomyolysis mimicking deep vein thrombophlebitis. (2315785)
1990
27
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988
28
Pheochromocytoma and Conn's syndrome in Denmark 1977-1981. (3472432)
1986
29
Quantitative selenium-75-cholesterol imaging and computed tomography of the adrenal glands in Conn's syndrome. (7135126)
1982
30
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. (7014043)
1981
31
Conn's syndrome in a patient with acromegaly. (7016705)
1981
32
Primary hyperparathyroidism in a patient with Conn's syndrome. (7383950)
1980
33
The structure of the juxtaglomerular apparatus in Addison's disease, Bartter's syndrome, and in Conn's syndrome: a comparative, morphometric, light microscopic study on serial secions. (818792)
1976
34
Nursing care study: Conn's syndrome. (1044099)
1976
35
Conn's syndrome. (4699809)
1973
36
Urinary excretion of tetrahydroaldosterone in normal subjects and in patients with adrenal insufficiency and Conn's syndrome. (4678197)
1972
37
The diagnosis of primary aldosteronism (Conn's syndrome). (A case report). (5025979)
1972
38
Studies on the biosynthesis of aldosterone in solitary adenoma and in nodular hyperplasia of the adrenal cortex in patients exhibiting Conn's syndrome. (5395005)
1969
39
Renal mastocytosis in a case of Conn's syndrome. (5602588)
1967
40
The aldosterone-renin constellation in Conn's syndrome. (4294143)
1967
41
Conn's syndrome. A detailed study on corticoid metabolites in the urine in two operated cases. (5908976)
1966
42
HYPOKALEMIC ALKALOSIS WITH ADRENAL TUMOR: A CASE REPORT. CONN'S SYNDROME OR DRUG-INDUCED HYPOKALEMIC ALKALOSIS. (14256705)
1965
43
CONN'S SYNDROME WITH ASSOCIATED PREGNANCY. (14341826)
1965
44
PLASMA RENIN IN A CASE OF CONN'S SYNDROME WITH FIBRINOID LESIONS: USE OF SPINONOLACTONE IN TREATMENT. (14213078)
1964
45
CATHETERIZATION OF THE LEFT ADRENAL VEIN FOR CONTRAST INJECTION AND STEROID ANALYSIS IN A CASE OF CONN'S SYNDROME. (14213891)
1964
46
CONN'S SYNDROME. (14077792)
1963
47
Modification of the effects of aldosterone on electrolyte excretion in man by simultaneous administration of corticosterone and hydrocortisone. Relevance to Conn's syndrome. (13854575)
1960
48
Conn's syndrome. (13591287)
1958
49
Conn's syndrome with severe hypertension. (13287082)
1956
50
Experimental production of morphological changes resembling Conn's syndrome. (13377711)
1956

Variations for Conn's Syndrome

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Expression for genes affiliated with Conn's Syndrome

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Expression patterns in normal tissues for genes affiliated with Conn's Syndrome

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Pathways for genes affiliated with Conn's Syndrome

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Pathways related to Conn's Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4REN, INHA
2
Show member pathways
9.0NR3C2, REN, CYP11B2

Compounds for genes affiliated with Conn's Syndrome

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Compounds related to Conn's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone44 2410.9REN, CYP11B2
2benazepril44 50 1111.9REN, CYP11B2
3glycyrrhetinic acid44 2410.8REN, NR3C2
4drospirenone44 28 50 1112.8REN, NR3C2
5Cortexolone249.8CYP11B2, NR3C2
6deoxycorticosterone28 2410.8NR3C2, CYP11B2
7glycyrrhizin44 2810.8NR3C2, REN
8hydralazine44 50 1111.8CYP11B2, REN
9cortisol28 2410.8NR3C2, CYP11B2
10thiazide449.8REN, NR3C2
11atenolol44 50 28 24 1113.8REN, CYP11B2
12irbesartan44 28 50 1112.8CYP11B2, REN
13aldosterone28 24 1111.8NR3C2, CYP11B2
14felodipine44 28 1111.7NR3C2, REN
15metyrapone44 61 1111.7CYP11B2, NR3C2
16metoclopramide44 50 1111.7CYP11B2, REN
1717-hydroxyprogesterone44 2410.7REN, CYP11B2
18cortisone44 2410.7NR3C2, CYP11B2
19candesartan44 50 28 1112.6CYP11B2, REN
20carbenoxolone44 28 1111.6REN, NR3C2
21enalapril44 50 1111.6REN, NR3C2
22tetrahydroaldosterone449.4CYP11B2, REN, NR3C2
23fludrocortisone44 28 1111.4NR3C2, REN, CYP11B2
24eplerenone44 61 28 1112.4CYP11B2, REN, NR3C2
2511 deoxycortisol449.4REN, NR3C2, CYP11B2
26doca449.4NR3C2, CYP11B2, REN
27hydrochlorothiazide44 28 50 24 1113.4CYP11B2, NR3C2, REN
28spironolactone44 61 28 50 1113.4CYP11B2, REN, NR3C2
2911beta-hydroxysteroid449.4CYP11B2, NR3C2, REN
30ang ii449.4REN, CYP11B2, NR3C2
31losartan44 50 28 1112.4NR3C2, CYP11B2, REN
32corticosterone44 61 2411.4NR3C2, CYP11B2, REN
33hydrocortisone44 2 61 1112.4CYP11B2, REN, NR3C2
34androstenedione44 2410.3INHA, REN, CYP11B2
353beta-hydroxysteroid449.2INHA, CYP11B2, NR3C2
36ribonucleic acid449.1INHA, CYP11B2, NR3C2
37nifedipine44 28 50 1112.0CYP11B2, KCNJ5, REN
38estradiol44 24 1110.9NR3C2, REN, INHA
39acth448.8CYP11B2, INHA, REN, NR3C2
40forskolin44 50 1110.8INHA, REN, CYP11B2
41steroid448.7REN, CYP11B2, NR3C2, INHA
42dopamine44 28 24 1111.7REN, KCNJ5, NR3C2
43haloperidol44 50 28 2 1112.6KCNJ5, REN, NR3C2, CYP11B2
44norepinephrine44 24 1110.6NR3C2, REN, KCNJ5, CYP11B2
45potassium44 24 1110.6NR3C2, REN, KCNJ5, CYP11B2
46sodium44 249.6NR3C2, REN, CYP11B2, KCNJ5
47nitric oxide44 24 1110.5CYP11B2, REN, KCNJ5, NR3C2
48glucose448.5REN, NR3C2, KCNJ5, CYP11B2
49testosterone44 61 24 1111.4NR3C2, INHA, KCNJ5, CYP11B2
50lysine448.3NR3C2, KCNJ5, CYP11B2

GO Terms for genes affiliated with Conn's Syndrome

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Biological processes related to Conn's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1male gonad developmentGO:0085849.4REN, INHA

Products for genes affiliated with Conn's Syndrome

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  • Antibodies
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Sources for Conn's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet