MCID: CNN003
MIFTS: 48

Conn's Syndrome

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Conn's Syndrome

MalaCards integrated aliases for Conn's Syndrome:

Name: Conn's Syndrome 12 14
Primary Hyperaldosteronism 12 50 29
Conn Syndrome 12 50 69
Primary Aldosteronism 12 50
Hyperaldosteronism 42 69
Mineralocorticoid Excess 50
Aldosteronism Primary 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12028
ICD10 33 E26.0 E26.01
ICD9CM 35 255.12
MeSH 42 D006929
NCIt 47 C34510
UMLS 69 C1384514

Summaries for Conn's Syndrome

NIH Rare Diseases : 50 primary hyperaldosteronism is a disorder caused by excess production of the hormonealdosterone by the adrenal glands. the main symptom of primary hyperaldosteronism is high blood pressure (hypertension), but other symptoms may include headaches, weakness, swelling (edema), and muscle spasms (tetany). the cause of primary hyperaldosteronism can vary. one cause may be an adenoma, or benign tumor, on the adrenal glands, which causes them to produce too much aldosterone. if primary hyperaldosteronism is caused by an adenoma, it is known as conn’s syndrome. the condition may also be caused by enlarged adrenal glands without adenomas (adrenal hyperplasia).  in some cases, primary hyperaldosteronism is inherited in an autosomal dominant manner, but in most cases the exact cause of the disease is unknown (idiopathic). a diagnosis is made by testing the blood for high levels of aldosterone. treatment for conn’s syndrome includes surgical removal of the adenomas. medication is used to treat primary hyperaldosteronism if it is caused by adrenal hyperplasia. last updated: 7/26/2016

MalaCards based summary : Conn's Syndrome, also known as primary hyperaldosteronism, is related to apparent mineralocorticoid excess and primary aldosteronism, seizures, and neurologic abnormalities. An important gene associated with Conn's Syndrome is CACNA1H (Calcium Voltage-Gated Channel Subunit Alpha1 H), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Insulin secretion. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and bone, and related phenotypes are cardiovascular system and growth/size/body region

Disease Ontology : 12 An adrenal admenoma characterized by over production of aldosterone.

Related Diseases for Conn's Syndrome

Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
id Related Disease Score Top Affiliating Genes
1 apparent mineralocorticoid excess 12.6
2 primary aldosteronism, seizures, and neurologic abnormalities 12.2
3 aldosterone-producing adenoma 11.6
4 familial hyperaldosteronism 11.2
5 adrenal cortical carcinoma 10.8
6 marden-walker syndrome 10.7 NR3C2 REN
7 hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy 10.7 NR3C2 REN
8 long qt syndrome 13 10.7 NR3C2 REN
9 spastic ataxia 2 10.6 CYP11B1 CYP11B2
10 carotid artery thrombosis 10.6 POMC REN
11 cholangiolocellular carcinoma 10.6 POMC REN
12 familial hypopituitarism 10.5 POMC REN
13 uterine corpus adenocarcinofibroma 10.5 POMC REN
14 cystic fibrosis and congenital absence of the vas deferens 10.5 AGTR1 REN
15 early onset absence epilepsy 10.5 CACNA1H POMC
16 pfeiffer syndrome 10.4 CYP11B1 POMC
17 bronchiectasis with or without elevated sweat chloride 1 10.4 CYP11B2 NR3C2 REN
18 aortopulmonary window 10.4 AGTR1 CYP11B2
19 atrial septal defect 7, with or without av conduction defects 10.4 NPPA REN
20 fibular aplasia ectrodactyly 10.4 AGTR1 REN
21 repetitive stress injuries 10.4 NPPA REN
22 female breast upper-outer quadrant cancer 10.4 AGTR1 KCNJ5
23 cleft lip and palate malrotation cardiopathy 10.4 CYP21A2 POMC
24 broad ligament malignant neoplasm 10.3 AGTR1 REN
25 cascade stomach 10.3 AGTR1 REN
26 north american indian childhood cirrhosis 10.3 NR3C2 POMC REN
27 myopia 10.3 NPPA REN
28 renal tubular dysgenesis 10.3 AGTR1 REN
29 idiopathic juxtafoveal retinal telangiectasia 10.3 NPPA NR3C2
30 gastrojejunal ulcer 10.3 CYP17A1 CYP21A2
31 adenocarcinoma 10.2 AGTR1 NR3C2 REN
32 synovial chondromatosis 10.2 NPPA POMC
33 pyogenic arthritis, pyoderma gangrenosum and acne 10.2 NPPA REN
34 perrault syndrome 10.2 AGTR1 NR3C2 REN
35 laryngostenosis 10.2 AGTR1 CYP11B2 NR3C2
36 astrakhan spotted fever 10.2 POMC REN
37 weill-marchesani syndrome 10.2 CYP17A1 CYP21A2
38 hypertrichosis of eyelid 10.1 AGTR1 NR3C2
39 liver sarcoma 10.1 CYP17A1 CYP21A2
40 monosomy 13q34 10.1 CYP21A2 POMC REN
41 silver-russell syndrome due to 11p15 microduplication 10.1 NPPA REN
42 dressler's syndrome 10.1 CYP21A2 POMC REN
43 acute myocarditis 10.1 CYP21A2 POMC
44 adrenal cortex disease 10.1 CYP21A2 NR3C2 POMC
45 male reproductive organ benign neoplasm 10.0 CYP11B2 KCNJ5 POMC REN
46 bronchiectasis with or without elevated sweat chloride 2 10.0 NR3C2 REN
47 urinary bladder posterior wall cancer 10.0 NPPA REN
48 microphthalmia, isolated, with coloboma 7 10.0 CYP11B2 CYP21A2 NR3C2 REN
49 kunjin encephalitis 9.9 CYP17A1 CYP21A2
50 branchiootorenal/branchiootic syndrome 9.9 CYP11B2 CYP21A2 KCNJ5 REN

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to Conn's Syndrome

Symptoms & Phenotypes for Conn's Syndrome

MGI Mouse Phenotypes related to Conn's Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 AGTR1 CACNA1H CYP11B1 CYP11B2 KCNJ5 NPPA
2 growth/size/body region MP:0005378 9.76 CACNA1H CYP11B1 CYP11B2 NR3C2 POMC PRSS8
3 homeostasis/metabolism MP:0005376 9.61 AGTR1 CYP11B1 CYP11B2 CYP17A1 NPPA NR3C2
4 renal/urinary system MP:0005367 9.17 AGTR1 CYP11B1 CYP11B2 NPPA NR3C2 POMC

Drugs & Therapeutics for Conn's Syndrome

Drugs for Conn's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2 Racepinephrine Approved Phase 4,Phase 3,Phase 2
3
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Captopril Approved Phase 4 62571-86-2 44093
6
Eplerenone Approved Phase 4,Phase 3 107724-20-9 150310 443872
7
Spironolactone Approved Phase 4,Phase 3 1952-01-7, 52-01-7 5833
8
Losartan Approved Phase 4 114798-26-4 3961
9
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
10 Adrenergic Agents Phase 4,Phase 3,Phase 2
11 Adrenergic Agonists Phase 4,Phase 3,Phase 2
12 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
13 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
14 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
15 Autonomic Agents Phase 4,Phase 3,Phase 2
16 Bronchodilator Agents Phase 4,Phase 3,Phase 2
17 Epinephryl borate Phase 4,Phase 3,Phase 2
18 Mydriatics Phase 4,Phase 3,Phase 2
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
21 Respiratory System Agents Phase 4,Phase 3,Phase 2
22 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
23 Antiparkinson Agents Phase 4
24 Dopamine Agents Phase 4
25 Dopamine agonists Phase 4
26 Hormone Antagonists Phase 4,Phase 3,Phase 2
27 Hormones Phase 4,Phase 3,Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
29 Angiotensin-Converting Enzyme Inhibitors Phase 4
30 Antihypertensive Agents Phase 4
31 HIV Protease Inhibitors Phase 4
32
protease inhibitors Phase 4
33 diuretics Phase 4,Phase 3
34 Diuretics, Potassium Sparing Phase 4,Phase 3
35 insulin Phase 4
36 Insulin, Globin Zinc Phase 4
37 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3
38 Mineralocorticoids Phase 4,Phase 3
39 Natriuretic Agents Phase 4,Phase 3
40 Angiotensin II Type 1 Receptor Blockers Phase 4
41 Angiotensin Receptor Antagonists Phase 4
42 Angiotensinogen Phase 4
43 Anti-Arrhythmia Agents Phase 4
44 Coagulants Phase 4
45 Fertility Agents Phase 4
46 Kallikreins Phase 4
47
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2 50-23-7 5754 657311
48
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
49 Anesthetics Phase 2, Phase 3
50 Adrenocorticotropic Hormone Phase 3

Interventional clinical trials:

(show all 49)

id Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 The Therapeutic Effect of Bromocriptin in Patients With Primary Aldosteronism Unknown status NCT00451672 Phase 4 bromocriptine
3 Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism Completed NCT00155064 Phase 4 captopril, Losartan (drug)
4 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
5 Aldosterone Antagonism and Microvascular Function Recruiting NCT01887119 Phase 4 Eplerenone
6 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
7 Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension Completed NCT00138944 Phase 3 placebo;eplerenone
8 Dynamic Hormone Diagnostics in Endocrine Disease Not yet recruiting NCT02934399 Phase 2, Phase 3
9 Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary Hyperaldosteronism Completed NCT00732771 Phase 2 LCI699
10 Open-label Study on Treatment of Primary Aldosteronism With Everolimus Recruiting NCT03174171 Phase 2 Everolimus 0.75 mg
11 Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism Unknown status NCT00173082
12 Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Unknown status NCT01267747
13 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
14 Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity Unknown status NCT00917345 captopril test
15 Diagnostic Properties of Aldosterone-Renin Ratio in Primary Aldosteronism Among Hypertensives. Unknown status NCT00407784 eplerenone
16 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
17 Anesthesia Management of Retroperitoneal Adrenalectomies Unknown status NCT00894335
18 Optimizing Diagnosis Of Primary Aldosteronism Completed NCT02755519
19 Primary Hyperaldosteronism and Ischemia-reperfusion Injury Completed NCT01978132
20 The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism Completed NCT02216721
21 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
22 Study of CS-3150 in Patients With Primary Aldosteronism Completed NCT02885662 CS-3150
23 Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in China Completed NCT01459042
24 Intraoperative Analysis of Cortisol During Adrenal Vein Sampling Completed NCT01761344
25 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501
26 Study of Myocardial Interstitial Fibrosis in Hyperaldosteronism Completed NCT02938910
27 Adrenal Vein Sampling International Study (AVIS Study) Completed NCT01234220
28 ARBITRAGE : cARdiotoxicity Profile of aBIraTeRone in prostAte Cancer : a pharmacoviGilancE Study Completed NCT03243604 L02 (sex hormones used in treatment of neoplastic diseases) and G03 (sex hormones)
29 Aldosterone, Microvascular Function and Salt-sensitivity Completed NCT02068781
30 Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment Completed NCT01897727 Spironolactone;BP medication uptitration
31 Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy Completed NCT01676025
32 Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure Completed NCT00001176
33 Screening for Primary Aldosteronism in a Population of Patients With Hypertension Recruiting NCT03105531
34 Chongqing Primary Aldosteronism Study Recruiting NCT03224312
35 Primary Aldosteronism In Hypertensive Patients in China Recruiting NCT03155139
36 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847 Mineralocorticoid Receptor Antagonists
37 Primary Aldosteronism in Western Norway Recruiting NCT02832388
38 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308 mineralocorticoid receptor antagonist
39 Renal Sympathetic Denervation From The Adventitia on Hypertension Recruiting NCT02642445
40 Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study) Recruiting NCT02804321
41 Adrenal Tumors - Pathogenesis and Therapy Recruiting NCT00669266
42 Omics Signature in the Diagnosis of Hypertension Recruiting NCT02772315
43 The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension Recruiting NCT01996449 Eplerenone;Amlodipine
44 11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism Active, not recruiting NCT01567111
45 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Active, not recruiting NCT02030587
46 Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study Enrolling by invitation NCT02257450
47 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism Not yet recruiting NCT02756754
48 IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism Not yet recruiting NCT02945904
49 Microvascular Function in Primary Aldosteronism Withdrawn NCT02096939 Antihypertensive medication

Search NIH Clinical Center for Conn's Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hyperaldosteronism

Genetic Tests for Conn's Syndrome

Genetic tests related to Conn's Syndrome:

id Genetic test Affiliating Genes
1 Primary Hyperaldosteronism 29

Anatomical Context for Conn's Syndrome

MalaCards organs/tissues related to Conn's Syndrome:

39
Adrenal Gland, Testes, Bone, Prostate, Kidney, Cortex, Adrenal Cortex

Publications for Conn's Syndrome

Articles related to Conn's Syndrome:

(show top 50) (show all 127)
id Title Authors Year
1
Laparoscopic Adrenalectomy for Conn's Syndrome is Beneficial to Patients and is Cost Effective in England. ( 28498785 )
2017
2
Clinical Case of the Month: PERSISTENT HYPERTENSION IN A YOUNG WOMAN: A CLASSIC PRESENTATION OF CONN'S SYNDROME. ( 26986864 )
2016
3
Adrenal Vein Sampling for Conn's Syndrome: Diagnosis and Clinical Outcomes. ( 26854152 )
2015
4
Contralateral adrenal abnormalities in Conn's syndrome. ( 26237993 )
2015
5
Aldosterone deficiency after unilateral adrenalectomy for Conn's syndrome: a case report and literature review. ( 25604311 )
2015
6
A case of Conn's syndrome presenting with painfull muscular weakness. ( 23715367 )
2013
7
Hypokalemia- induced myopathy and massive creatine kinase elevation as first manifestation of Conn's syndrome. ( 24249961 )
2013
8
Cortex sparing laparoscopic adrenalectomy in a patient with Conn's syndrome. ( 25931842 )
2013
9
KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome. ( 22323562 )
2012
10
Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report. ( 21980052 )
2011
11
Aldosterone increases Na+ -K+ -ATPase activity in skeletal muscle of patients with Conn's syndrome. ( 21044117 )
2011
12
Conn's syndrome unmasked by thiazide-induced hypokalaemia. ( 22041837 )
2011
13
A case of Conn's syndrome revealed after oral sodium phosphate (Fleet) preparation for colonoscopy. ( 20402838 )
2010
14
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. ( 20953222 )
2010
15
Is hyperaldosteronism a pathognomonic feature of conn's syndrome? ( 23133229 )
2010
16
Laparoscopic adrenalectomy for Conn's syndrome: report of the initial six cases. ( 20099423 )
2009
17
Conn's syndrome. ( 19190201 )
2009
18
[Conn's syndrome]. ( 19099278 )
2009
19
Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. ( 18543405 )
2008
20
Open adrenalectomy surgery: an obsolete technique? About a case of Conn's syndrome. ( 18572739 )
2008
21
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. ( 18772856 )
2008
22
Retroperitoneoscopic adrenalectomy in Conn's syndrome caused by adrenal adenomas or nodular hyperplasia. ( 18343972 )
2008
23
Delay in the diagnosis of Conn's syndrome: a single-center experience over 30 years. ( 18663152 )
2008
24
Rare oxygen, a rare way to diagnose Conn's syndrome. ( 28657013 )
2008
25
Conn's syndrome in pregnancy successfully treated with amiloride. ( 17999306 )
2007
26
Long-term results of endoscopic adrenalectomy for Conn's syndrome. ( 17305298 )
2007
27
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. ( 17315030 )
2007
28
Lessons in the diagnosis and management of Conn's syndrome. ( 17990731 )
2007
29
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). ( 17100688 )
2006
30
Laparoscopic adrenalectomy for Conn's syndrome. ( 16441999 )
2006
31
Conn's syndrome (primary hyperaldosteronism) simulating polymyositis. ( 15034751 )
2005
32
Association between Crohn's disease and Conn's syndrome. A report of two cases. ( 15985978 )
2005
33
Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn's syndrome. ( 16222471 )
2005
34
Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn's syndrome with an ominous clinical course. ( 15788646 )
2005
35
Conn's syndrome presenting as depression. ( 15930081 )
2005
36
Shift from Conn's syndrome to Cushing's syndrome in a recurrent adrenocortical carcinoma. ( 16260420 )
2005
37
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. ( 15751612 )
2005
38
Renal transplantation unveils Conn's syndrome: a case report. ( 15621124 )
2004
39
Roentgenoendovascular treatment of Conn's syndrome. ( 15622394 )
2004
40
Laparoscopic adrenalectomy for Conn's syndrome complicated by ipsilateral congenital pelvic kidney. ( 15791386 )
2004
41
Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome). ( 15241622 )
2004
42
CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. ( 12933492 )
2003
43
Conn's syndrome associated with Behcet's disease. ( 12589107 )
2003
44
Hypokalemic rhabdomyolysis aggravated by diuretics complicating Conn's syndrome without acute renal failure. ( 11837808 )
2002
45
Conn's syndrome and atrial fibrillation. ( 11421216 )
2001
46
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). ( 11422106 )
2001
47
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. ( 11827421 )
2001
48
Outpatient laparoscopic adrenalectomy in patients with Conn's syndrome. ( 11591947 )
2001
49
Conn's syndrome and bilateral renal artery stenosis in the presence of multiple renal arteries. ( 11383914 )
2001
50
Calcium-channel blockade can mask the diagnosis of Conn's syndrome. ( 10715768 )
1999

Variations for Conn's Syndrome

ClinVar genetic disease variations for Conn's Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CACNA1H NM_021098.2(CACNA1H): c.4645A> G (p.Met1549Val) single nucleotide variant Pathogenic rs786205050 GRCh37 Chromosome 16, 1262024: 1262024

Expression for Conn's Syndrome

Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for Conn's Syndrome

Pathways related to Conn's Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
2
Show member pathways
12.02 AGTR1 CACNA1H CYP11B2 CYP21A2
3 11.53 CACNA1H CYP11B1 CYP21A2 POMC
4
Show member pathways
11.3 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
5
Show member pathways
11.26 CYP11B1 CYP11B2 CYP17A1 CYP21A2
6
Show member pathways
10.25 CYP11B1 CYP11B2 CYP17A1 CYP21A2

GO Terms for Conn's Syndrome

Biological processes related to Conn's Syndrome according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 steroid metabolic process GO:0008202 9.73 CYP11B1 CYP11B2 CYP17A1 CYP21A2
2 regulation of blood pressure GO:0008217 9.71 CYP11B1 NPPA POMC REN
3 cellular response to hormone stimulus GO:0032870 9.67 CACNA1H CYP11B1 CYP11B2
4 steroid biosynthetic process GO:0006694 9.67 CYP11B1 CYP11B2 CYP17A1 CYP21A2
5 C21-steroid hormone biosynthetic process GO:0006700 9.51 CYP11B1 CYP11B2
6 cellular response to potassium ion GO:0035865 9.5 CACNA1H CYP11B1 CYP11B2
7 renin-angiotensin regulation of aldosterone production GO:0002018 9.48 AGTR1 REN
8 mineralocorticoid biosynthetic process GO:0006705 9.46 CYP11B2 CYP21A2
9 sterol metabolic process GO:0016125 9.46 CYP11B1 CYP11B2 CYP17A1 CYP21A2
10 glucocorticoid biosynthetic process GO:0006704 9.43 CYP11B1 CYP17A1 CYP21A2
11 aldosterone biosynthetic process GO:0032342 9.13 CACNA1H CYP11B1 CYP11B2
12 cortisol biosynthetic process GO:0034651 8.8 CACNA1H CYP11B1 CYP11B2

Molecular functions related to Conn's Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.76 CYP11B1 CYP11B2 CYP17A1 CYP21A2
2 iron ion binding GO:0005506 9.62 CYP11B1 CYP11B2 CYP17A1 CYP21A2
3 steroid binding GO:0005496 9.4 CYP21A2 NR3C2
4 steroid hydroxylase activity GO:0008395 9.37 CYP11B2 CYP21A2
5 corticosterone 18-monooxygenase activity GO:0047783 9.26 CYP11B1 CYP11B2
6 heme binding GO:0020037 9.26 CYP11B1 CYP11B2 CYP17A1 CYP21A2
7 steroid 11-beta-monooxygenase activity GO:0004507 9.16 CYP11B1 CYP11B2
8 neuropeptide hormone activity GO:0005184 9.13 NPPA
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Sources for Conn's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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