MCID: CNN003
MIFTS: 50

Conn's Syndrome malady

Summaries for Conn's Syndrome

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An adrenal admenoma characterized by over production of aldosterone.

MalaCards: Conn's Syndrome, also known as primary hyperaldosteronism, is related to hypertension and adenoma. An important gene associated with Conn's Syndrome is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are Renin-angiotensin system and Endogenous sterols. The compounds saralasin and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and cortex, and related mouse phenotypes are muscle and mortality/aging.

Aliases & Classifications for Conn's Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 56SNOMED-CT, 60UMLS, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

conn's syndrome 8 42
primary hyperaldosteronism 8 42
primary aldosteronism 8 42
primary aldosteronism, hypokalemic alkalosis, hypertension and muscle weakness 42
aldosteronism primary 44
conns syndrome 10


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Disease Ontology8 DOID:12028
ICD9CM27 255.12
NCIt39 C34510
MeSH34 D006929

Related Diseases for Conn's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1POMC, NR3C2, NPPA, REN, CYP11B2, CYP11B1
2adenoma30.9CYP11B1, NR3C2, KCNJ5, INHA, AGTR2, POMC
3adrenal adenoma30.8AGTR1, CYP11B1, REN, INHA, POMC
4essential hypertension30.7NPPA, NR3C2, AGTR2, CYP11B1, CYP11B2, REN
5hyperaldosteronism30.6NR3C2, AGTR1, POMC, CYP11B1, CYP11B2, KCNJ5
6cushing's syndrome30.4NR3C2, POMC
7hypokalemia30.3NR3C2, POMC, CYP11B2, REN
8thyroiditis30.3POMC
9adrenocortical carcinoma30.2POMC, AGTR1, CYP11B1, CYP11B2, INHA
10renovascular hypertension30.1NPPA, REN, AGTR1
11diabetes mellitus29.9POMC, REN, AGTR1, NR3C2, NPPA, KCNJ5
12hyperandrogenism29.9HSD3B1, POMC
13proteinuria29.9NR3C2, AGTR2, CYP11B2, AGTR1, REN
14glucocorticoid-remediable aldosteronism29.9NR3C2, CYP11B2, CYP11B1, POMC, REN
15myocardial infarction29.9AGTR1, AGTR2, NPPA, KCNJ5, CYP11B2, REN
16malignant hypertension10.4
17primary hyperparathyroidism10.3
18hyperparathyroidism10.3
19myopathy10.3
20nephrocalcinosis10.1
21adrenal carcinoma10.1
22primary aldosteronism, seizures, and neurologic abnormalities10.1
23twin-to-twin transfusion syndrome10.0
24familial partial lipodystrophy10.0
25polycystic kidney disease10.0
26hypokalemic periodic paralysis10.0
27vitiligo10.0
28autosomal dominant disease10.0
29hepatitis10.0
30hypothyroidism10.0
31lipodystrophy10.0
32peritonitis10.0
33renal adenoma10.0
34image syndrome10.0
35polycystic kidney disease, autosomal dominant10.0
36familial hyperaldosteronism type 210.0
37hyperaldosteronism, familial, type iii10.0
38myocardial stunning10.0KCNJ5
39coronary heart disease10.0AGTR1
40cerebrovascular disease10.0AGTR1
41mitral valve prolapse10.0AGTR1
42ureteral obstruction10.0AGTR1
43fibromuscular dysplasia10.0REN
44glomerulonephritis10.0AGTR1
45inappropriate adh syndrome10.0NPPA
46mitral valve disease10.0NPPA
47low renin hypertension10.0CYP11B2, REN
48apparent mineralocorticoid excess syndrome10.0NR3C2
49vesicoureteral reflux10.0AGTR2, AGTR1
50renal tubular dysgenesis10.0AGTR1, REN

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Clinical Features for Conn's Syndrome

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Drugs & Therapeutics for Conn's Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Conn's Syndrome

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Anatomical Context for Conn's Syndrome

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32MalaCards
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MalaCards organs/tissues related to Conn's Syndrome:

32
Kidney, Adrenal gland, Cortex, Skeletal muscle, Testes, Adrenal cortex

Animal Models for Conn's Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Conn's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7NPPA, NR3C2, AGTR2, CYP11B2, REN, ASPH
2MP:00107687.0AGTR2, AGTR1, POMC, CYP11B2, REN, INHA
3MP:00053676.9NPPA, NR3C2, AGTR2, AGTR1, POMC, CYP11B1
4MP:00053766.0NPPA, NR3C2, AGTR2, AGTR1, POMC, CYP11B1
5MP:00053855.9ASPH, KCNJ5, NPPA, NR3C2, AGTR2, AGTR1

Publications for Conn's Syndrome

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50PubMed
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Articles related to Conn's Syndrome:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
A case of Conn's syndrome presenting with painfull muscular weakness. (23715367)
2013
2
KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome. (22323562)
2012
3
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. (20953222)
2010
4
Conn's syndrome]. (19099278)
2009
5
Laparoscopic adrenalectomy for Conn's syndrome: report of the initial six cases. (20099423)
2009
6
Retroperitoneoscopic adrenalectomy in Conn's syndrome caused by adrenal adenomas or nodular hyperplasia. (18343972)
2008
7
Lessons in the diagnosis and management of Conn's syndrome. (17990731)
2007
8
Long-term results of endoscopic adrenalectomy for Conn's syndrome. (17305298)
2007
9
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. (17315030)
2007
10
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
11
Laparoscopic adrenalectomy for Conn's syndrome. (16441999)
2006
12
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
13
Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn's syndrome. (16222471)
2005
14
Shift from Conn's syndrome to Cushing's syndrome in a recurrent adrenocortical carcinoma. (16260420)
2005
15
Conn's syndrome (primary hyperaldosteronism) simulating polymyositis. (15034751)
2005
16
Roentgenoendovascular treatment of Conn's syndrome. (15622394)
2004
17
Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome). (15241622)
2004
18
Conn's syndrome associated with Behcet's disease. (12589107)
2003
19
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). (11422106)
2001
20
Conn's syndrome and atrial fibrillation. (11421216)
2001
21
Clinics in diagnostic imaging (39). Conn's syndrome due to adrenocortical adenoma (Conn's tumour). (10560278)
1999
22
Conn's syndrome: a simple diagnostic approach. (10613001)
1999
23
Anaesthesia for Conn's syndrome. (10403872)
1999
24
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes. (9863625)
1998
25
Hyperglycemia, lumbar plexopathy and hypokalemic rhabdomyolysis complicating Conn's syndrome. (9043752)
1997
26
Adrenal carcinoma presenting as Conn's syndrome. (9145197)
1997
27
Combined Conn's and Cushing's syndrome: an unusual presentation of adrenal adenoma. (8533534)
1995
28
Conn's syndrome due to a renin-responsive adrenal adenoma. (8505755)
1993
29
Altered primary haemostasis in Conn's syndrome. (1448795)
1992
30
Familial Conn's syndrome. (1494530)
1992
31
Conn's syndrome or LityA8ski-Conn syndrome? (1307768)
1992
32
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988
33
Arterial blood pressure and plasma and body electrolytes in idiopathic hyperaldosteronism: a comparison with primary hyperaldosteronism (Conn's syndrome) and essential hypertension. (6530544)
1984
34
Body sodium and blood pressure: abnormal and different correlations in Conn's syndrome, renal artery stenosis and essential hypertension. (6657673)
1983
35
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. (7014043)
1981
36
Conn's syndrome in a patient with acromegaly. (7016705)
1981
37
Primary hyperparathyroidism in a patient with Conn's syndrome. (7383950)
1980
38
Conn's syndrome. A follow-up of thirteen surgically treated cases. (1071948)
1976
39
Primary aldosteronism. Conn's syndrome. A rational approach to diagnosis and treatment. (5026387)
1972
40
Studies on the biosynthesis of aldosterone in solitary adenoma and in nodular hyperplasia of the adrenal cortex in patients exhibiting Conn's syndrome. (5395005)
1969
41
The aldosterone-renin constellation in Conn's syndrome. (4294143)
1967
42
Conn's syndrome in a Bantu patient. (6022966)
1967
43
HYPOKALEMIC ALKALOSIS WITH ADRENAL TUMOR: A CASE REPORT. CONN'S SYNDROME OR DRUG-INDUCED HYPOKALEMIC ALKALOSIS. (14256705)
1965
44
Conn's syndrome due to adrenal hyperplasia with hypertrophy of zona glomerulosa, relieved by unilateral adrenalectomy. (5853475)
1965
45
Plasma concentration of renin in a patient with Conn's syndrome with fibrinoid lesions of the renal arterioles: the effect of treatment with spironolactone. (5845288)
1965
46
CATHETERIZATION OF THE LEFT ADRENAL VEIN FOR CONTRAST INJECTION AND STEROID ANALYSIS IN A CASE OF CONN'S SYNDROME. (14213891)
1964
47
Case of Conn's syndrome. (13797070)
1959
48
Conn's syndrome. (13591287)
1958
49
Experimental production of morphological changes resembling Conn's syndrome. (13377711)
1956
50
Conn's syndrome, caused by adrenocortical hyperplasia; pathogenesis of the signs and symptoms. (13381394)
1956

Genetic Variations for Conn's Syndrome

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Expression for genes affiliated with Conn's Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conn's Syndrome

Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for genes affiliated with Conn's Syndrome

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Conn's Syndrome

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Conn's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1saralasin449.6REN, AGTR1, AGTR2
2cyclosporin a44 28 5911.6KCNJ5, NR3C2
3tetrahydroaldosterone449.6REN, CYP11B2, NR3C2
4irbesartan44 28 49 1112.5AGTR1, CYP11B2, AGTR2, REN
5metoclopramide44 1110.3REN, NPPA, CYP11B2, CYP11B1
6benazepril44 1110.3NPPA, AGTR1, REN
721-deoxycortisol44 2410.3POMC, CYP11B2, CYP11B1
8enalapril44 49 1111.3REN, AGTR2, NPPA, AGTR1
9deoxycorticosterone28 2410.2HSD3B1, NR3C2, CYP11B2, CYP11B1
10trandolapril44 1110.2NPPA, AGTR1, REN
11eplerenone44 59 28 1112.2REN, AGTR1, NR3C2, CYP11B2
12nitroglycerin44 1110.2NPPA, AGTR1, REN, KCNJ5
13aldosterone28 11 2411.2CYP11B2, CYP11B1, NR3C2, AGTR1
14hydrochlorothiazide44 49 28 11 2413.1REN, AGTR1, NR3C2, CYP11B2
1518-hydroxycorticosterone44 2410.1POMC, CYP11B2, REN, CYP11B1
16etomidate44 1110.1POMC, CYP11B2, CYP11B1
17felodipine44 28 1110.9AGTR1, REN, NR3C2, NPPA
18cilazapril44 119.9REN, AGTR1, NPPA
19cgmp44 289.9AGTR2, AGTR1, NPPA, KCNJ5, REN
20nifedipine44 49 28 1111.9CYP11B2, AGTR1, KCNJ5, REN, NPPA
21captopril44 28 49 59 1112.7AGTR2, AGTR1, REN, NR3C2, NPPA
2217-hydroxyprogesterone44 249.7CYP11B1, POMC, REN, HSD3B1, CYP11B2
23metyrapone59 44 1110.7CYP11B1, NR3C2, POMC, CYP11B2
24furosemide44 49 59 28 11 2413.6POMC, AGTR1, NPPA, REN
25prostaglandin448.6KCNJ5, AGTR2, AGTR1, REN, NPPA
2611 deoxycortisol448.5REN, CYP11B2, CYP11B1, NR3C2, POMC
27doca448.5NR3C2, POMC, CYP11B1, CYP11B2, REN
28ang ii448.5REN, CYP11B2, AGTR1, AGTR2, NR3C2, NPPA
29losartan44 49 28 1111.5AGTR1, CYP11B2, NR3C2, NPPA, REN, AGTR2
30cortisol28 249.5POMC, CYP11B2, HSD3B1, NR3C2, CYP11B1
31androstenedione44 249.4INHA, REN, POMC, CYP11B2, HSD3B1, CYP11B1
32cortisone44 249.4CYP11B2, POMC, AGTR1, CYP11B1, NR3C2
33corticosterone44 59 2410.4REN, CYP11B1, NR3C2, POMC, CYP11B2
34hydrocortisone44 2 59 1111.3REN, CYP11B1, POMC, NR3C2, CYP11B2
35fludrocortisone44 28 1110.3REN, CYP11B2, POMC, NR3C2, NPPA
363beta-hydroxysteroid448.2POMC, NR3C2, HSD3B1, CYP11B1, CYP11B2, INHA
37forskolin44 49 1110.1CYP11B2, CYP11B1, POMC, REN, AGTR1, NPPA
3811beta-hydroxysteroid448.1REN, CYP11B1, POMC, AGTR1, NR3C2, CYP11B2
39potassium44 11 2410.1AGTR1, REN, KCNJ5, NPPA, NR3C2, CYP11B1
40catecholamine447.9NR3C2, AGTR2, AGTR1, POMC, REN, NPPA
41estradiol44 11 249.8NR3C2, POMC, CYP11B1, INHA, REN, AGTR1
42sodium44 248.8KCNJ5, CYP11B2, NPPA, REN, NR3C2, CYP11B1
43haloperidol44 28 2 49 1111.7POMC, NPPA, CYP11B2, REN, AGTR1, KCNJ5
44oxygen44 248.6NR3C2, NPPA, CYP11B2, ASPH, KCNJ5, CYP11B1
45norepinephrine44 11 249.4POMC, REN, CYP11B2, AGTR1, NPPA, AGTR2
46spironolactone49 44 59 28 1111.3NPPA, POMC, REN, CYP11B2, CYP11B1, AGTR1
47testosterone44 59 11 2410.3POMC, NR3C2, INHA, KCNJ5, HSD3B1, CYP11B1
48acth447.3POMC, AGTR1, CYP11B1, CYP11B2, REN, INHA
49steroid447.3POMC, CYP11B1, CYP11B2, REN, INHA, HSD3B1
50arginine447.2REN, NPPA, CYP11B2, POMC, CYP11B1, AGTR1

GO Terms for genes affiliated with Conn's Syndrome

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16Gene Ontology
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Biological processes related to Conn's Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1aldosterone biosynthetic processGO:03234210.0CYP11B2, CYP11B1
2cortisol biosynthetic processGO:03465110.0CYP11B2, CYP11B1
3cellular response to potassium ionGO:0358659.9CYP11B2, CYP11B1
4C21-steroid hormone biosynthetic processGO:0067009.9CYP11B2, CYP11B1
5cellular response to hormone stimulusGO:0328709.8CYP11B2, CYP11B1
6glucocorticoid biosynthetic processGO:0067049.8HSD3B1, CYP11B1
7sterol metabolic processGO:0161259.7CYP11B2, CYP11B1
8renin-angiotensin regulation of aldosterone productionGO:0020189.7REN, AGTR1, AGTR2
9mineralocorticoid biosynthetic processGO:0067059.7HSD3B1, CYP11B1, CYP11B2
10steroid metabolic processGO:0082029.6HSD3B1, CYP11B1, CYP11B2
11steroid biosynthetic processGO:0066949.3TRERF1, HSD3B1
12regulation of blood pressureGO:0082178.5REN, CYP11B1, POMC, AGTR2, NPPA

Molecular functions related to Conn's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:0045079.9CYP11B2, CYP11B1
2angiotensin type II receptor activityGO:0049459.8AGTR1, AGTR2
3electron carrier activityGO:0090559.4ASPH, CYP11B2, CYP11B1
4hormone activityGO:0051798.5INHA, POMC, NPPA
5receptor bindingGO:0051028.4NPPA, POMC, REN, INHA

Products for genes affiliated with Conn's Syndrome

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Sources for Conn's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet