MCID: CNN003
MIFTS: 50

Conn's Syndrome malady

Summaries for Conn's Syndrome

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An adrenal admenoma characterized by over production of aldosterone.

MalaCards: Conn's Syndrome, also known as primary hyperaldosteronism, is related to hypertension and adenoma. An important gene associated with Conn's Syndrome is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are Renin-angiotensin system and Endogenous sterols. The compounds saralasin and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and cortex, and related mouse phenotypes are muscle and mortality/aging.

Aliases & Classifications for Conn's Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 56SNOMED-CT, 60UMLS, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

conn's syndrome 8 42
primary hyperaldosteronism 8 42
primary aldosteronism 8 42
primary aldosteronism, hypokalemic alkalosis, hypertension and muscle weakness 42
aldosteronism primary 44
conns syndrome 10


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Disease Ontology8 DOID:12028
ICD9CM27 255.12
NCIt39 C34510
MeSH34 D006929

Related Diseases for Conn's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1POMC, NR3C2, NPPA, REN, CYP11B2, CYP11B1
2adenoma30.9CYP11B1, NR3C2, KCNJ5, INHA, AGTR2, POMC
3adrenal adenoma30.8AGTR1, CYP11B1, REN, INHA, POMC
4essential hypertension30.7NPPA, NR3C2, AGTR2, CYP11B1, CYP11B2, REN
5hyperaldosteronism30.6NR3C2, AGTR1, POMC, CYP11B1, CYP11B2, KCNJ5
6cushing's syndrome30.4NR3C2, POMC
7hypokalemia30.3NR3C2, POMC, CYP11B2, REN
8thyroiditis30.3POMC
9adrenocortical carcinoma30.2POMC, AGTR1, CYP11B1, CYP11B2, INHA
10renovascular hypertension30.1NPPA, REN, AGTR1
11diabetes mellitus29.9POMC, REN, AGTR1, NR3C2, NPPA, KCNJ5
12hyperandrogenism29.9HSD3B1, POMC
13proteinuria29.9NR3C2, AGTR2, CYP11B2, AGTR1, REN
14glucocorticoid-remediable aldosteronism29.9NR3C2, CYP11B2, CYP11B1, POMC, REN
15myocardial infarction29.9AGTR1, AGTR2, NPPA, KCNJ5, CYP11B2, REN
16malignant hypertension10.4
17primary hyperparathyroidism10.3
18hyperparathyroidism10.3
19myopathy10.3
20nephrocalcinosis10.1
21adrenal carcinoma10.1
22primary aldosteronism, seizures, and neurologic abnormalities10.1
23twin-to-twin transfusion syndrome10.0
24familial partial lipodystrophy10.0
25polycystic kidney disease10.0
26hypokalemic periodic paralysis10.0
27vitiligo10.0
28autosomal dominant disease10.0
29hepatitis10.0
30hypothyroidism10.0
31lipodystrophy10.0
32peritonitis10.0
33renal adenoma10.0
34image syndrome10.0
35polycystic kidney disease, autosomal dominant10.0
36familial hyperaldosteronism type 210.0
37hyperaldosteronism, familial, type iii10.0
38myocardial stunning10.0KCNJ5
39coronary heart disease10.0AGTR1
40cerebrovascular disease10.0AGTR1
41mitral valve prolapse10.0AGTR1
42ureteral obstruction10.0AGTR1
43fibromuscular dysplasia10.0REN
44glomerulonephritis10.0AGTR1
45inappropriate adh syndrome10.0NPPA
46mitral valve disease10.0NPPA
47low renin hypertension10.0CYP11B2, REN
48apparent mineralocorticoid excess syndrome10.0NR3C2
49vesicoureteral reflux10.0AGTR2, AGTR1
50renal tubular dysgenesis10.0AGTR1, REN

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Clinical Features for Conn's Syndrome

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Drugs & Therapeutics for Conn's Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Conn's Syndrome

Drug clinical trials:

Search ClinicalTrials for Conn's Syndrome

Search NIH Clinical Center for Conn's Syndrome

Search CenterWatch for Conn's Syndrome

Genetic Tests for Conn's Syndrome

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Anatomical Context for Conn's Syndrome

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32MalaCards
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MalaCards organs/tissues related to Conn's Syndrome:

32
Kidney, Adrenal gland, Cortex, Skeletal muscle, Testes, Adrenal cortex

Animal Models for Conn's Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Conn's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7NPPA, NR3C2, AGTR2, CYP11B2, REN, ASPH
2MP:00107687.0AGTR2, AGTR1, POMC, CYP11B2, REN, INHA
3MP:00053676.9NPPA, NR3C2, AGTR2, AGTR1, POMC, CYP11B1
4MP:00053766.0NPPA, NR3C2, AGTR2, AGTR1, POMC, CYP11B1
5MP:00053855.9ASPH, KCNJ5, NPPA, NR3C2, AGTR2, AGTR1

Publications for Conn's Syndrome

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Sources:
50PubMed
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Articles related to Conn's Syndrome:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Conn's syndrome unmasked by thiazide-induced hypokalaemia. (22041837)
2011
2
Aldosterone increases Na+ -K+ -ATPase activity in skeletal muscle of patients with Conn's syndrome. (21044117)
2011
3
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. (20953222)
2010
4
Is hyperaldosteronism a pathognomonic feature of conn's syndrome? (23133229)
2010
5
Conn's syndrome. (19190201)
2009
6
Open adrenalectomy surgery: an obsolete technique? About a case of Conn's syndrome. (18572739)
2008
7
Lessons in the diagnosis and management of Conn's syndrome. (17990731)
2007
8
Long-term results of endoscopic adrenalectomy for Conn's syndrome. (17305298)
2007
9
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. (17315030)
2007
10
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
11
Laparoscopic adrenalectomy for Conn's syndrome. (16441999)
2006
12
Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn's syndrome with an ominous clinical course. (15788646)
2005
13
Roentgenoendovascular treatment of Conn's syndrome. (15622394)
2004
14
Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome). (15241622)
2004
15
Renal transplantation unveils Conn's syndrome: a case report. (15621124)
2004
16
Conn's syndrome associated with Behcet's disease. (12589107)
2003
17
CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. (12933492)
2003
18
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. (11827421)
2001
19
Conn's syndrome and atrial fibrillation. (11421216)
2001
20
Calcium-channel blockade can mask the diagnosis of Conn's syndrome. (10715768)
1999
21
Conn's syndrome: no longer a needle in a haystack? (10209556)
1998
22
Adrenal carcinoma presenting as Conn's syndrome. (9145197)
1997
23
Primary aldosteronism (Conn's syndrome). (8530580)
1995
24
Combined Conn's and Cushing's syndrome: an unusual presentation of adrenal adenoma. (8533534)
1995
25
Altered primary haemostasis in Conn's syndrome. (1448795)
1992
26
Conn's syndrome can cause malignant hypertension. (1583635)
1992
27
Familial Conn's syndrome. (1494530)
1992
28
Conn's syndrome or LityA8ski-Conn syndrome? (1307768)
1992
29
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988
30
Pheochromocytoma and Conn's syndrome in Denmark 1977-1981. (3472432)
1986
31
Factors affecting the secretion of 18-hydroxycortisol, a novel steroid of relevance to Conn's syndrome. (3002670)
1985
32
Surgical management of primary aldosteronism (Conn's syndrome), a correctable cause of hypertension. (6598066)
1984
33
Body sodium and blood pressure: abnormal and different correlations in Conn's syndrome, renal artery stenosis and essential hypertension. (6657673)
1983
34
Radioimmunoassay of aldosterone in adrenal venous effluent in a case of Conn's syndrome. (4796426)
1973
35
Urinary excretion of tetrahydroaldosterone in normal subjects and in patients with adrenal insufficiency and Conn's syndrome. (4678197)
1972
36
Conn's syndrome. (4657816)
1972
37
Primary aldosteronism--Conn's syndrome (a case report). (4658679)
1972
38
Studies on the biosynthesis of aldosterone in solitary adenoma and in nodular hyperplasia of the adrenal cortex in patients exhibiting Conn's syndrome. (5395005)
1969
39
Renal mastocytosis in a case of Conn's syndrome. (5602588)
1967
40
Conn's syndrome in a Bantu patient. (6022966)
1967
41
Conn's syndrome. A detailed study on corticoid metabolites in the urine in two operated cases. (5908976)
1966
42
Primary aldosteronism due to adrenocortical adenoma (Conn's syndrome). (5955092)
1966
43
CONN'S SYNDROME WITH ASSOCIATED PREGNANCY. (14341826)
1965
44
CONN'S SYNDROME AND SUBARACHNOID HAEMORRHAGE. (14255992)
1965
45
Conn's syndrome due to adrenal hyperplasia with hypertrophy of zona glomerulosa, relieved by unilateral adrenalectomy. (5853475)
1965
46
PLASMA RENIN IN A CASE OF CONN'S SYNDROME WITH FIBRINOID LESIONS: USE OF SPINONOLACTONE IN TREATMENT. (14213078)
1964
47
A biochemical and pathological investigation of adrenal tissues from patients with Conn's syndrome. (14015653)
1962
48
Case of Conn's syndrome. (13797070)
1959
49
Conn's syndrome. (13591287)
1958
50
Conn's syndrome with severe hypertension. (13287082)
1956

Genetic Variations for Conn's Syndrome

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Expression for genes affiliated with Conn's Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conn's Syndrome

Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for genes affiliated with Conn's Syndrome

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Conn's Syndrome

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Conn's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1saralasin449.6REN, AGTR1, AGTR2
2cyclosporin a44 28 5911.6KCNJ5, NR3C2
3tetrahydroaldosterone449.6REN, CYP11B2, NR3C2
4irbesartan44 28 49 1112.5AGTR1, CYP11B2, AGTR2, REN
5metoclopramide44 1110.3REN, NPPA, CYP11B2, CYP11B1
6benazepril44 1110.3NPPA, AGTR1, REN
721-deoxycortisol44 2410.3POMC, CYP11B2, CYP11B1
8enalapril44 49 1111.3REN, AGTR2, NPPA, AGTR1
9deoxycorticosterone28 2410.2HSD3B1, NR3C2, CYP11B2, CYP11B1
10trandolapril44 1110.2NPPA, AGTR1, REN
11eplerenone44 59 28 1112.2REN, AGTR1, NR3C2, CYP11B2
12nitroglycerin44 1110.2NPPA, AGTR1, REN, KCNJ5
13aldosterone28 11 2411.2CYP11B2, CYP11B1, NR3C2, AGTR1
14hydrochlorothiazide44 49 28 11 2413.1REN, AGTR1, NR3C2, CYP11B2
1518-hydroxycorticosterone44 2410.1POMC, CYP11B2, REN, CYP11B1
16etomidate44 1110.1POMC, CYP11B2, CYP11B1
17felodipine44 28 1110.9AGTR1, REN, NR3C2, NPPA
18cilazapril44 119.9REN, AGTR1, NPPA
19cgmp44 289.9AGTR2, AGTR1, NPPA, KCNJ5, REN
20nifedipine44 49 28 1111.9CYP11B2, AGTR1, KCNJ5, REN, NPPA
21captopril44 28 49 59 1112.7AGTR2, AGTR1, REN, NR3C2, NPPA
2217-hydroxyprogesterone44 249.7CYP11B1, POMC, REN, HSD3B1, CYP11B2
23metyrapone59 44 1110.7CYP11B1, NR3C2, POMC, CYP11B2
24furosemide44 49 59 28 11 2413.6POMC, AGTR1, NPPA, REN
25prostaglandin448.6KCNJ5, AGTR2, AGTR1, REN, NPPA
2611 deoxycortisol448.5REN, CYP11B2, CYP11B1, NR3C2, POMC
27doca448.5NR3C2, POMC, CYP11B1, CYP11B2, REN
28ang ii448.5REN, CYP11B2, AGTR1, AGTR2, NR3C2, NPPA
29losartan44 49 28 1111.5AGTR1, CYP11B2, NR3C2, NPPA, REN, AGTR2
30cortisol28 249.5POMC, CYP11B2, HSD3B1, NR3C2, CYP11B1
31androstenedione44 249.4INHA, REN, POMC, CYP11B2, HSD3B1, CYP11B1
32cortisone44 249.4CYP11B2, POMC, AGTR1, CYP11B1, NR3C2
33corticosterone44 59 2410.4REN, CYP11B1, NR3C2, POMC, CYP11B2
34hydrocortisone44 2 59 1111.3REN, CYP11B1, POMC, NR3C2, CYP11B2
35fludrocortisone44 28 1110.3REN, CYP11B2, POMC, NR3C2, NPPA
363beta-hydroxysteroid448.2POMC, NR3C2, HSD3B1, CYP11B1, CYP11B2, INHA
37forskolin44 49 1110.1CYP11B2, CYP11B1, POMC, REN, AGTR1, NPPA
3811beta-hydroxysteroid448.1REN, CYP11B1, POMC, AGTR1, NR3C2, CYP11B2
39potassium44 11 2410.1AGTR1, REN, KCNJ5, NPPA, NR3C2, CYP11B1
40catecholamine447.9NR3C2, AGTR2, AGTR1, POMC, REN, NPPA
41estradiol44 11 249.8NR3C2, POMC, CYP11B1, INHA, REN, AGTR1
42sodium44 248.8KCNJ5, CYP11B2, NPPA, REN, NR3C2, CYP11B1
43haloperidol44 28 2 49 1111.7POMC, NPPA, CYP11B2, REN, AGTR1, KCNJ5
44oxygen44 248.6NR3C2, NPPA, CYP11B2, ASPH, KCNJ5, CYP11B1
45norepinephrine44 11 249.4POMC, REN, CYP11B2, AGTR1, NPPA, AGTR2
46spironolactone49 44 59 28 1111.3NPPA, POMC, REN, CYP11B2, CYP11B1, AGTR1
47testosterone44 59 11 2410.3POMC, NR3C2, INHA, KCNJ5, HSD3B1, CYP11B1
48acth447.3POMC, AGTR1, CYP11B1, CYP11B2, REN, INHA
49steroid447.3POMC, CYP11B1, CYP11B2, REN, INHA, HSD3B1
50arginine447.2REN, NPPA, CYP11B2, POMC, CYP11B1, AGTR1

GO Terms for genes affiliated with Conn's Syndrome

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16Gene Ontology
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Biological processes related to Conn's Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1aldosterone biosynthetic processGO:03234210.0CYP11B2, CYP11B1
2cortisol biosynthetic processGO:03465110.0CYP11B2, CYP11B1
3cellular response to potassium ionGO:0358659.9CYP11B2, CYP11B1
4C21-steroid hormone biosynthetic processGO:0067009.9CYP11B2, CYP11B1
5cellular response to hormone stimulusGO:0328709.8CYP11B2, CYP11B1
6glucocorticoid biosynthetic processGO:0067049.8HSD3B1, CYP11B1
7sterol metabolic processGO:0161259.7CYP11B2, CYP11B1
8renin-angiotensin regulation of aldosterone productionGO:0020189.7REN, AGTR1, AGTR2
9mineralocorticoid biosynthetic processGO:0067059.7HSD3B1, CYP11B1, CYP11B2
10steroid metabolic processGO:0082029.6HSD3B1, CYP11B1, CYP11B2
11steroid biosynthetic processGO:0066949.3TRERF1, HSD3B1
12regulation of blood pressureGO:0082178.5REN, CYP11B1, POMC, AGTR2, NPPA

Molecular functions related to Conn's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:0045079.9CYP11B2, CYP11B1
2angiotensin type II receptor activityGO:0049459.8AGTR1, AGTR2
3electron carrier activityGO:0090559.4ASPH, CYP11B2, CYP11B1
4hormone activityGO:0051798.5INHA, POMC, NPPA
5receptor bindingGO:0051028.4NPPA, POMC, REN, INHA

Products for genes affiliated with Conn's Syndrome

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  • Antibodies
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Sources for Conn's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet