MCID: CNN003
MIFTS: 40

Conn's Syndrome malady

Rare diseases, Endocrine diseases categories

Summaries for Conn's Syndrome

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Disease Ontology:9 An adrenal admenoma characterized by over production of aldosterone.

MalaCards based summary: Conn's Syndrome, also known as conn syndrome, is related to hyperaldosteronism and adrenal adenoma. An important gene associated with Conn's Syndrome is REN (renin), and among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds 18-hydroxycorticosterone and benazepril have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and cortex, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Conn's Syndrome

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Conn's Syndrome, Aliases & Descriptions:

Name: Conn's Syndrome 9
Conn Syndrome 9 41 60
Primary Hyperaldosteronism 9 41
Primary Aldosteronism 9 41
 
Mineralocorticoid Excess 41
Aldosteronism Primary 43
Conns Syndrome 11


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:12028
NCIt38 C34510
ICD9CM27 255.12
MeSH33 D006929
ICD1025 E26.0

Related Diseases for Conn's Syndrome

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Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1hyperaldosteronism31.4CYP11B2, KCNJ5, REN, NR3C2
2adrenal adenoma30.9REN, CYP11B2
3cushing's syndrome30.8REN, CYP11B2
4hypokalemia30.6CYP11B2, REN, NR3C2
5hypoaldosteronism30.6CYP11B2, REN
6kidney disease30.5REN, NR3C2
7pseudohypoaldosteronism30.5NR3C2, REN
8adrenal cortical adenoma30.5REN, INHA
9congenital adrenal hyperplasia30.5CYP11B2, REN
10adrenocortical carcinoma30.4INHA, CYP11B2
11liddle syndrome30.4NR3C2, REN, CYP11B2
12atrial fibrillation30.3CYP11B2, NR3C2
13aldosteronism, glucocorticoid-remediable30.1NR3C2, REN, CYP11B2
14adenoma30.1CYP11B2, KCNJ5, INHA, REN, NR3C2
15proteinuria30.0NR3C2, REN, CYP11B2
16myocardial infarction29.5CYP11B2, KCNJ5, REN, NR3C2
17apparent mineralocorticoid excess11.0
18malignant hypertension10.4
19familial hyperaldosteronism10.4
20adrenal cortical carcinoma10.4
21primary hyperparathyroidism10.3
22hyperparathyroidism10.3
23myopathy10.3
24primary aldosteronism, seizures, and neurologic abnormalities10.3
25adrenal carcinoma10.3
26thyroiditis10.3
27hyperaldosteronism, familial, type iii10.2
28pseudohypoaldosteronism, type iie10.2REN, NR3C2
29renal fibrosis10.2REN, NR3C2
30renovascular hypertension10.2
31nephrocalcinosis10.2
32addison's disease10.2REN, CYP11B2
33metabolic acidosis10.1NR3C2, REN
34gynecomastia10.1INHA, NR3C2
35microvascular complications of diabetes 310.1NR3C2, REN
36hyperaldosteronism, familial, type ii10.1
37twin-to-twin transfusion syndrome10.1
38hepatitis10.1
39polycystic kidney disease10.1
40familial partial lipodystrophy10.1
41artery disease10.1
42hypothyroidism10.1
43lipodystrophy10.1
44peritonitis10.1
45renal artery disease10.1
46glucagonoma10.1
47polymyositis10.1
48polycystic ovary syndrome10.1NR3C2, INHA
49wilms tumor10.1INHA, REN
50primary hyperoxaluria10.0NR3C2, REN

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Symptoms for Conn's Syndrome

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Drugs & Therapeutics for Conn's Syndrome

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Drug clinical trials:

Search ClinicalTrials for Conn's Syndrome

Search NIH Clinical Center for Conn's Syndrome

Genetic Tests for Conn's Syndrome

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Anatomical Context for Conn's Syndrome

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MalaCards organs/tissues related to Conn's Syndrome:

31
Kidney, Adrenal gland, Cortex, Skeletal muscle, Testes, Adrenal cortex

Animal Models for Conn's Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Conn's Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.0NR3C2, REN, CYP11B2
2MP:00053678.9CYP11B2, REN, NR3C2
3MP:00053788.4CYP11B2, INHA, REN, NR3C2
4MP:00053768.1NR3C2, REN, INHA, CYP11B2
5MP:00053857.6NR3C2, REN, INHA, KCNJ5, CYP11B2

Publications for Conn's Syndrome

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Articles related to Conn's Syndrome:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Surgical outcomes following laparoscopic adrenalectomy for treatment of Conn's syndrome (primary hyperaldosteronism) between 1999 and 2006. (20953222)
2010
2
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. (18772856)
2008
3
Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. (18543405)
2008
4
Lessons in the diagnosis and management of Conn's syndrome. (17990731)
2007
5
Conn's syndrome in pregnancy successfully treated with amiloride. (17999306)
2007
6
Long-term results of endoscopic adrenalectomy for Conn's syndrome. (17305298)
2007
7
Primary aldosteronism: current knowledge and controversies in Conn's syndrome. (17315030)
2007
8
Atrial fibrillation associated with hypokalemia due to primary hyperaldosteronism (Conn's syndrome). (17100688)
2006
9
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
10
Association between Crohn's disease and Conn's syndrome. A report of two cases. (15985978)
2005
11
Roentgenoendovascular treatment of Conn's syndrome. (15622394)
2004
12
Laparoscopic adrenalectomy for Conn's syndrome complicated by ipsilateral congenital pelvic kidney. (15791386)
2004
13
CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. (12933492)
2003
14
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome). (11422106)
2001
15
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. (11827421)
2001
16
Clinics in diagnostic imaging (39). Conn's syndrome due to adrenocortical adenoma (Conn's tumour). (10560278)
1999
17
Conn's syndrome: a simple diagnostic approach. (10613001)
1999
18
Anaesthesia for Conn's syndrome. (10403872)
1999
19
Calcium-channel blockade can mask the diagnosis of Conn's syndrome. (10715768)
1999
20
Adrenal angiotensin II type 1 and type 2 receptors in Cushing's and Conn's syndromes. (9863625)
1998
21
Primary aldosteronism (Conn's syndrome). (8530580)
1995
22
Refractory hypertension due to Conn's syndrome. (8121854)
1994
23
Altered primary haemostasis in Conn's syndrome. (1448795)
1992
24
Conn's syndrome can cause malignant hypertension. (1583635)
1992
25
Conn's syndrome. (2246200)
1990
26
Conn's syndrome with rhabdomyolysis mimicking deep vein thrombophlebitis. (2315785)
1990
27
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988
28
Pheochromocytoma and Conn's syndrome in Denmark 1977-1981. (3472432)
1986
29
Quantitative selenium-75-cholesterol imaging and computed tomography of the adrenal glands in Conn's syndrome. (7135126)
1982
30
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. (7014043)
1981
31
Conn's syndrome in a patient with acromegaly. (7016705)
1981
32
Primary hyperparathyroidism in a patient with Conn's syndrome. (7383950)
1980
33
The structure of the juxtaglomerular apparatus in Addison's disease, Bartter's syndrome, and in Conn's syndrome: a comparative, morphometric, light microscopic study on serial secions. (818792)
1976
34
Nursing care study: Conn's syndrome. (1044099)
1976
35
Conn's syndrome. (4699809)
1973
36
Urinary excretion of tetrahydroaldosterone in normal subjects and in patients with adrenal insufficiency and Conn's syndrome. (4678197)
1972
37
The diagnosis of primary aldosteronism (Conn's syndrome). (A case report). (5025979)
1972
38
Studies on the biosynthesis of aldosterone in solitary adenoma and in nodular hyperplasia of the adrenal cortex in patients exhibiting Conn's syndrome. (5395005)
1969
39
Renal mastocytosis in a case of Conn's syndrome. (5602588)
1967
40
The aldosterone-renin constellation in Conn's syndrome. (4294143)
1967
41
Conn's syndrome. A detailed study on corticoid metabolites in the urine in two operated cases. (5908976)
1966
42
HYPOKALEMIC ALKALOSIS WITH ADRENAL TUMOR: A CASE REPORT. CONN'S SYNDROME OR DRUG-INDUCED HYPOKALEMIC ALKALOSIS. (14256705)
1965
43
CONN'S SYNDROME WITH ASSOCIATED PREGNANCY. (14341826)
1965
44
PLASMA RENIN IN A CASE OF CONN'S SYNDROME WITH FIBRINOID LESIONS: USE OF SPINONOLACTONE IN TREATMENT. (14213078)
1964
45
CATHETERIZATION OF THE LEFT ADRENAL VEIN FOR CONTRAST INJECTION AND STEROID ANALYSIS IN A CASE OF CONN'S SYNDROME. (14213891)
1964
46
CONN'S SYNDROME. (14077792)
1963
47
Modification of the effects of aldosterone on electrolyte excretion in man by simultaneous administration of corticosterone and hydrocortisone. Relevance to Conn's syndrome. (13854575)
1960
48
Conn's syndrome. (13591287)
1958
49
Conn's syndrome with severe hypertension. (13287082)
1956
50
Experimental production of morphological changes resembling Conn's syndrome. (13377711)
1956

Variations for Conn's Syndrome

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Expression for genes affiliated with Conn's Syndrome

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Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for genes affiliated with Conn's Syndrome

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Pathways related to Conn's Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4REN, INHA
2
Show member pathways
9.0NR3C2, REN, CYP11B2

Compounds for genes affiliated with Conn's Syndrome

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Compounds related to Conn's Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
118-hydroxycorticosterone43 2410.9REN, CYP11B2
2benazepril43 49 1211.9REN, CYP11B2
3glycyrrhetinic acid43 2410.8REN, NR3C2
4drospirenone43 28 49 1212.8REN, NR3C2
5Cortexolone249.8CYP11B2, NR3C2
6deoxycorticosterone28 2410.8NR3C2, CYP11B2
7glycyrrhizin43 2810.8NR3C2, REN
8hydralazine43 49 1211.8CYP11B2, REN
9cortisol28 2410.8NR3C2, CYP11B2
10thiazide439.8REN, NR3C2
11atenolol43 49 28 24 1213.8REN, CYP11B2
12irbesartan43 28 49 1212.8CYP11B2, REN
13aldosterone28 24 1211.8NR3C2, CYP11B2
14felodipine43 28 1211.7NR3C2, REN
15metyrapone43 59 1211.7CYP11B2, NR3C2
16metoclopramide43 49 1211.7CYP11B2, REN
1717-hydroxyprogesterone43 2410.7REN, CYP11B2
18cortisone43 2410.7NR3C2, CYP11B2
19candesartan43 49 28 1212.6CYP11B2, REN
20carbenoxolone43 28 1211.6REN, NR3C2
21enalapril43 49 1211.6REN, NR3C2
22tetrahydroaldosterone439.4CYP11B2, REN, NR3C2
23fludrocortisone43 28 1211.4NR3C2, REN, CYP11B2
24eplerenone43 59 28 1212.4CYP11B2, REN, NR3C2
2511 deoxycortisol439.4REN, NR3C2, CYP11B2
26doca439.4NR3C2, CYP11B2, REN
27hydrochlorothiazide43 28 49 24 1213.4CYP11B2, NR3C2, REN
28spironolactone43 59 28 49 1213.4CYP11B2, REN, NR3C2
2911beta-hydroxysteroid439.4CYP11B2, NR3C2, REN
30ang ii439.4REN, CYP11B2, NR3C2
31losartan43 49 28 1212.4NR3C2, CYP11B2, REN
32corticosterone43 59 2411.4NR3C2, CYP11B2, REN
33hydrocortisone43 2 59 1212.4CYP11B2, REN, NR3C2
34androstenedione43 2410.3INHA, REN, CYP11B2
353beta-hydroxysteroid439.2INHA, CYP11B2, NR3C2
36ribonucleic acid439.1INHA, CYP11B2, NR3C2
37nifedipine43 28 49 1212.0CYP11B2, KCNJ5, REN
38estradiol43 24 1210.9NR3C2, REN, INHA
39acth438.8CYP11B2, INHA, REN, NR3C2
40forskolin43 49 1210.8INHA, REN, CYP11B2
41steroid438.7REN, CYP11B2, NR3C2, INHA
42dopamine43 28 24 1211.7REN, KCNJ5, NR3C2
43haloperidol43 49 28 2 1212.6KCNJ5, REN, NR3C2, CYP11B2
44norepinephrine43 24 1210.6NR3C2, REN, KCNJ5, CYP11B2
45potassium43 24 1210.6NR3C2, REN, KCNJ5, CYP11B2
46sodium43 249.6NR3C2, REN, CYP11B2, KCNJ5
47nitric oxide43 24 1210.5CYP11B2, REN, KCNJ5, NR3C2
48glucose438.5REN, NR3C2, KCNJ5, CYP11B2
49testosterone43 59 24 1211.4NR3C2, INHA, KCNJ5, CYP11B2
50lysine438.3NR3C2, KCNJ5, CYP11B2

GO Terms for genes affiliated with Conn's Syndrome

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Biological processes related to Conn's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1male gonad developmentGO:00085849.4REN, INHA

Products for genes affiliated with Conn's Syndrome

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Sources for Conn's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet