MCID: CNN003
MIFTS: 50

Conn's Syndrome malady

Summaries for Conn's Syndrome

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An adrenal admenoma characterized by over production of aldosterone.

MalaCards: Conn's Syndrome, also known as primary hyperaldosteronism, is related to hypertension and adenoma. An important gene associated with Conn's Syndrome is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are Renin-angiotensin system and Endogenous sterols. The compounds saralasin and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal gland and cortex, and related mouse phenotypes are muscle and mortality/aging.

Aliases & Classifications for Conn's Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 56SNOMED-CT, 60UMLS, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

conn's syndrome 8 42
primary hyperaldosteronism 8 42
primary aldosteronism 8 42
primary aldosteronism, hypokalemic alkalosis, hypertension and muscle weakness 42
aldosteronism primary 44
conns syndrome 10


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Disease Ontology8 DOID:12028
ICD9CM27 255.12
NCIt39 C34510
MeSH34 D006929

Related Diseases for Conn's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Conn's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1POMC, NR3C2, NPPA, REN, CYP11B2, CYP11B1
2adenoma30.9CYP11B1, NR3C2, KCNJ5, INHA, AGTR2, POMC
3adrenal adenoma30.8AGTR1, CYP11B1, REN, INHA, POMC
4essential hypertension30.7NPPA, NR3C2, AGTR2, CYP11B1, CYP11B2, REN
5hyperaldosteronism30.6NR3C2, AGTR1, POMC, CYP11B1, CYP11B2, KCNJ5
6cushing's syndrome30.4NR3C2, POMC
7hypokalemia30.3NR3C2, POMC, CYP11B2, REN
8thyroiditis30.3POMC
9adrenocortical carcinoma30.2POMC, AGTR1, CYP11B1, CYP11B2, INHA
10renovascular hypertension30.1NPPA, REN, AGTR1
11diabetes mellitus29.9POMC, REN, AGTR1, NR3C2, NPPA, KCNJ5
12hyperandrogenism29.9HSD3B1, POMC
13proteinuria29.9NR3C2, AGTR2, CYP11B2, AGTR1, REN
14glucocorticoid-remediable aldosteronism29.9NR3C2, CYP11B2, CYP11B1, POMC, REN
15myocardial infarction29.9AGTR1, AGTR2, NPPA, KCNJ5, CYP11B2, REN
16malignant hypertension10.4
17primary hyperparathyroidism10.3
18hyperparathyroidism10.3
19myopathy10.3
20nephrocalcinosis10.1
21adrenal carcinoma10.1
22primary aldosteronism, seizures, and neurologic abnormalities10.1
23twin-to-twin transfusion syndrome10.0
24familial partial lipodystrophy10.0
25polycystic kidney disease10.0
26hypokalemic periodic paralysis10.0
27vitiligo10.0
28autosomal dominant disease10.0
29hepatitis10.0
30hypothyroidism10.0
31lipodystrophy10.0
32peritonitis10.0
33renal adenoma10.0
34image syndrome10.0
35polycystic kidney disease, autosomal dominant10.0
36familial hyperaldosteronism type 210.0
37hyperaldosteronism, familial, type iii10.0
38myocardial stunning10.0KCNJ5
39coronary heart disease10.0AGTR1
40cerebrovascular disease10.0AGTR1
41mitral valve prolapse10.0AGTR1
42ureteral obstruction10.0AGTR1
43fibromuscular dysplasia10.0REN
44glomerulonephritis10.0AGTR1
45inappropriate adh syndrome10.0NPPA
46mitral valve disease10.0NPPA
47low renin hypertension10.0CYP11B2, REN
48apparent mineralocorticoid excess syndrome10.0NR3C2
49vesicoureteral reflux10.0AGTR2, AGTR1
50renal tubular dysgenesis10.0AGTR1, REN

Graphical network of the top 20 diseases related to Conn's Syndrome:



Diseases related to conn's syndrome

Clinical Features for Conn's Syndrome

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Drugs & Therapeutics for Conn's Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Conn's Syndrome

Drug clinical trials:

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Search NIH Clinical Center for Conn's Syndrome

Search CenterWatch for Conn's Syndrome

Genetic Tests for Conn's Syndrome

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Anatomical Context for Conn's Syndrome

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32MalaCards
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MalaCards organs/tissues related to Conn's Syndrome:

32
Kidney, Adrenal gland, Cortex, Skeletal muscle, Testes, Adrenal cortex

Animal Models for Conn's Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Conn's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7NPPA, NR3C2, AGTR2, CYP11B2, REN, ASPH
2MP:00107687.0AGTR2, AGTR1, POMC, CYP11B2, REN, INHA
3MP:00053676.9NPPA, NR3C2, AGTR2, AGTR1, POMC, CYP11B1
4MP:00053766.0NPPA, NR3C2, AGTR2, AGTR1, POMC, CYP11B1
5MP:00053855.9ASPH, KCNJ5, NPPA, NR3C2, AGTR2, AGTR1

Publications for Conn's Syndrome

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50PubMed
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Articles related to Conn's Syndrome:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Hypokalemia- induced myopathy and massive creatine kinase elevation as first manifestation of Conn's syndrome. (24249961)
2013
2
Metastatic adrenocortical carcinoma presenting simultaneously with Cushing's and Conn's syndromes: a case report. (21980052)
2011
3
A case of Conn's syndrome revealed after oral sodium phosphate (Fleet) preparation for colonoscopy. (20402838)
2010
4
Combined Conn's syndrome and subclinical hypercortisolism from an adrenal adenoma associated with homolateral renal carcinoma. (18772856)
2008
5
Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. (18543405)
2008
6
Delay in the diagnosis of Conn's syndrome: a single-center experience over 30 years. (18663152)
2008
7
Conn's syndrome in pregnancy successfully treated with amiloride. (17999306)
2007
8
Association between Crohn's disease and Conn's syndrome. A report of two cases. (15985978)
2005
9
Conn's syndrome presenting as depression. (15930081)
2005
10
Laparoscopic adrenalectomy for Conn's syndrome complicated by ipsilateral congenital pelvic kidney. (15791386)
2004
11
Hypokalemic rhabdomyolysis aggravated by diuretics complicating Conn's syndrome without acute renal failure. (11837808)
2002
12
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. (11827421)
2001
13
Outpatient laparoscopic adrenalectomy in patients with Conn's syndrome. (11591947)
2001
14
Conn's syndrome and bilateral renal artery stenosis in the presence of multiple renal arteries. (11383914)
2001
15
Anaesthesia for Conn's syndrome. (10403872)
1999
16
Soft-tissue images. Adrenocortical adenocarcinoma presenting as Conn's syndrome. (10223065)
1999
17
Latent tetany associated with the hypokalaemia of Conn's syndrome. (9796569)
1998
18
Primary aldosteronism (Conn's syndrome). (8530580)
1995
19
Conn's syndrome due to adrenocortical adenoma--a rare but rewarding cause of curable hypertension. (8600610)
1995
20
Refractory hypertension due to Conn's syndrome. (8121854)
1994
21
Conn's syndrome. (2246200)
1990
22
Conn's syndrome with rhabdomyolysis mimicking deep vein thrombophlebitis. (2315785)
1990
23
Functional interpretation of the kidney juxtaglomerular apparatus using renin immunohistochemistry in Bartter's, pseudo-Bartter's and Conn's syndromes. (2130539)
1990
24
Aldosterone-producing tumors (Conn's syndrome). (2180043)
1990
25
Conn's syndrome due to an ectopic adrenal adenoma. (2616423)
1989
26
Conn's syndrome. Case report and a review of the syndrome of primary aldosteronism (SOPA). (6730466)
1984
27
Relation of blood pressure with body and plasma electrolytes in Conn's syndrome. (6681039)
1983
28
Quantitative selenium-75-cholesterol imaging and computed tomography of the adrenal glands in Conn's syndrome. (7135126)
1982
29
Conn's syndrome presenting as a subarachnoid haemorrhage. A case report. (7101085)
1982
30
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. (7014043)
1981
31
Response of aldosterone and 18-hydroxycorticosterone to angiotensin II in normal subjects and patients with essential hypertension, Conn's syndrome, and nontumorous hyperaldosteronism. (7262982)
1981
32
The structure of the juxtaglomerular apparatus in Addison's disease, Bartter's syndrome, and in Conn's syndrome: a comparative, morphometric, light microscopic study on serial secions. (818792)
1976
33
Nursing care study: Conn's syndrome. (1044099)
1976
34
Control of plasma aldosterone in a patient with Conn's syndrome before and during spironolactone medication. (211313)
1975
35
Malignant hypertension in a patient with Conn's syndrome. (4837570)
1974
36
Conn's syndrome. (4699809)
1973
37
Differential diagnosis of female hirsutism, Cushing's and Conn's syndrome. Quantitative sequential scintigraphy of the adrenals with 131-J-19-iodocholesterol. (4353565)
1973
38
The diagnosis of primary aldosteronism (Conn's syndrome). (A case report). (5025979)
1972
39
Hypokalemia with normal blood pressure preceding malignant hypertension in a patient with primary aldosteronism (Conn's syndrome). (4509127)
1972
40
Epinephro-phlebography in two cases of Conn's syndrome. (5724383)
1968
41
The aldosterone-renin constellation in Conn's syndrome. (4294143)
1967
42
Conn's syndrome complicated by fulminant pyelonephritis in an old patient. (6022097)
1967
43
CONN'S SYNDROME AND SUBARACHNOID HAEMORRHAGE. (14255992)
1965
44
CONN'S SYNDROME. (14077792)
1963
45
A case of Conn's syndrome. (14450735)
1962
46
Modification of the effects of aldosterone on electrolyte excretion in man by simultaneous administration of corticosterone and hydrocortisone. Relevance to Conn's syndrome. (13854575)
1960
47
Conn's syndrome. (13809046)
1960
48
Conn's syndrome: the effect of amphenone. (14402326)
1960
49
Conn's syndrome with severe hypertension. (13287082)
1956
50
CONN'S SYNDROME; primary aldosteronism. (14382535)
1955

Genetic Variations for Conn's Syndrome

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Expression for genes affiliated with Conn's Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conn's Syndrome

Search GEO for disease gene expression data for Conn's Syndrome.

Pathways for genes affiliated with Conn's Syndrome

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29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Conn's Syndrome

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Conn's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1saralasin449.6REN, AGTR1, AGTR2
2cyclosporin a44 28 5911.6KCNJ5, NR3C2
3tetrahydroaldosterone449.6REN, CYP11B2, NR3C2
4irbesartan44 28 49 1112.5AGTR1, CYP11B2, AGTR2, REN
5metoclopramide44 1110.3REN, NPPA, CYP11B2, CYP11B1
6benazepril44 1110.3NPPA, AGTR1, REN
721-deoxycortisol44 2410.3POMC, CYP11B2, CYP11B1
8enalapril44 49 1111.3REN, AGTR2, NPPA, AGTR1
9deoxycorticosterone28 2410.2HSD3B1, NR3C2, CYP11B2, CYP11B1
10trandolapril44 1110.2NPPA, AGTR1, REN
11eplerenone44 59 28 1112.2REN, AGTR1, NR3C2, CYP11B2
12nitroglycerin44 1110.2NPPA, AGTR1, REN, KCNJ5
13aldosterone28 11 2411.2CYP11B2, CYP11B1, NR3C2, AGTR1
14hydrochlorothiazide44 49 28 11 2413.1REN, AGTR1, NR3C2, CYP11B2
1518-hydroxycorticosterone44 2410.1POMC, CYP11B2, REN, CYP11B1
16etomidate44 1110.1POMC, CYP11B2, CYP11B1
17felodipine44 28 1110.9AGTR1, REN, NR3C2, NPPA
18cilazapril44 119.9REN, AGTR1, NPPA
19cgmp44 289.9AGTR2, AGTR1, NPPA, KCNJ5, REN
20nifedipine44 49 28 1111.9CYP11B2, AGTR1, KCNJ5, REN, NPPA
21captopril44 28 49 59 1112.7AGTR2, AGTR1, REN, NR3C2, NPPA
2217-hydroxyprogesterone44 249.7CYP11B1, POMC, REN, HSD3B1, CYP11B2
23metyrapone59 44 1110.7CYP11B1, NR3C2, POMC, CYP11B2
24furosemide44 49 59 28 11 2413.6POMC, AGTR1, NPPA, REN
25prostaglandin448.6KCNJ5, AGTR2, AGTR1, REN, NPPA
2611 deoxycortisol448.5REN, CYP11B2, CYP11B1, NR3C2, POMC
27doca448.5NR3C2, POMC, CYP11B1, CYP11B2, REN
28ang ii448.5REN, CYP11B2, AGTR1, AGTR2, NR3C2, NPPA
29losartan44 49 28 1111.5AGTR1, CYP11B2, NR3C2, NPPA, REN, AGTR2
30cortisol28 249.5POMC, CYP11B2, HSD3B1, NR3C2, CYP11B1
31androstenedione44 249.4INHA, REN, POMC, CYP11B2, HSD3B1, CYP11B1
32cortisone44 249.4CYP11B2, POMC, AGTR1, CYP11B1, NR3C2
33corticosterone44 59 2410.4REN, CYP11B1, NR3C2, POMC, CYP11B2
34hydrocortisone44 2 59 1111.3REN, CYP11B1, POMC, NR3C2, CYP11B2
35fludrocortisone44 28 1110.3REN, CYP11B2, POMC, NR3C2, NPPA
363beta-hydroxysteroid448.2POMC, NR3C2, HSD3B1, CYP11B1, CYP11B2, INHA
37forskolin44 49 1110.1CYP11B2, CYP11B1, POMC, REN, AGTR1, NPPA
3811beta-hydroxysteroid448.1REN, CYP11B1, POMC, AGTR1, NR3C2, CYP11B2
39potassium44 11 2410.1AGTR1, REN, KCNJ5, NPPA, NR3C2, CYP11B1
40catecholamine447.9NR3C2, AGTR2, AGTR1, POMC, REN, NPPA
41estradiol44 11 249.8NR3C2, POMC, CYP11B1, INHA, REN, AGTR1
42sodium44 248.8KCNJ5, CYP11B2, NPPA, REN, NR3C2, CYP11B1
43haloperidol44 28 2 49 1111.7POMC, NPPA, CYP11B2, REN, AGTR1, KCNJ5
44oxygen44 248.6NR3C2, NPPA, CYP11B2, ASPH, KCNJ5, CYP11B1
45norepinephrine44 11 249.4POMC, REN, CYP11B2, AGTR1, NPPA, AGTR2
46spironolactone49 44 59 28 1111.3NPPA, POMC, REN, CYP11B2, CYP11B1, AGTR1
47testosterone44 59 11 2410.3POMC, NR3C2, INHA, KCNJ5, HSD3B1, CYP11B1
48acth447.3POMC, AGTR1, CYP11B1, CYP11B2, REN, INHA
49steroid447.3POMC, CYP11B1, CYP11B2, REN, INHA, HSD3B1
50arginine447.2REN, NPPA, CYP11B2, POMC, CYP11B1, AGTR1

GO Terms for genes affiliated with Conn's Syndrome

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16Gene Ontology
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Biological processes related to Conn's Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1aldosterone biosynthetic processGO:03234210.0CYP11B2, CYP11B1
2cortisol biosynthetic processGO:03465110.0CYP11B2, CYP11B1
3cellular response to potassium ionGO:0358659.9CYP11B2, CYP11B1
4C21-steroid hormone biosynthetic processGO:0067009.9CYP11B2, CYP11B1
5cellular response to hormone stimulusGO:0328709.8CYP11B2, CYP11B1
6glucocorticoid biosynthetic processGO:0067049.8HSD3B1, CYP11B1
7sterol metabolic processGO:0161259.7CYP11B2, CYP11B1
8renin-angiotensin regulation of aldosterone productionGO:0020189.7REN, AGTR1, AGTR2
9mineralocorticoid biosynthetic processGO:0067059.7HSD3B1, CYP11B1, CYP11B2
10steroid metabolic processGO:0082029.6HSD3B1, CYP11B1, CYP11B2
11steroid biosynthetic processGO:0066949.3TRERF1, HSD3B1
12regulation of blood pressureGO:0082178.5REN, CYP11B1, POMC, AGTR2, NPPA

Molecular functions related to Conn's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:0045079.9CYP11B2, CYP11B1
2angiotensin type II receptor activityGO:0049459.8AGTR1, AGTR2
3electron carrier activityGO:0090559.4ASPH, CYP11B2, CYP11B1
4hormone activityGO:0051798.5INHA, POMC, NPPA
5receptor bindingGO:0051028.4NPPA, POMC, REN, INHA

Products for genes affiliated with Conn's Syndrome

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Sources for Conn's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet