MCID: CNS004
MIFTS: 55

Constipation malady

Gastrointestinal diseases category

Summaries for Constipation

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Constipation means that a person has three or fewer bowel movements in a week. the stool can be hard and dry. sometimes it is painful to pass. at one time or another, almost everyone gets constipated. in most cases, it lasts a short time and is not serious. there are many things you can do to prevent constipation. they include eating more fruits, vegetables and grains, which are high in fiber drinking plenty of water and other liquids getting enough exercise taking time to have a bowel movement when you need to using laxatives only if your doctor says you should asking your doctor if medicines you take may cause constipation it's not important that you have a bowel movement every day. if your bowel habits change, however, check with your doctor. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Constipation is related to irritable bowel syndrome and hirschsprung's disease. An important gene associated with Constipation is CLCN2 (chloride channel, voltage-sensitive 2), and among its related pathways are Regulation of Water Balance by Renal Aquaporins and Passive Transport by Aquaporins. The compounds phentolamine and kassinin have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and testes, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:63 Constipation (also known as costiveness or dyschezia) refers to bowel movements that are infrequent or... more...

Aliases & Classifications for Constipation

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 27ICD9CM, 60UMLS, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

constipation 8 10 33


External Ids:

Disease Ontology8 DOID:2089
MeSH34 D003248
ICD9CM27 564.00, 564.0
NCIt39 C37930
ICD1025 K59.0

Related Diseases for Constipation

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Constipation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome31.0HTR4, MLN, TAC1
2hirschsprung's disease30.4TAC1, VIP, NRTN
3diarrhea30.2PYY, MLN, TAC1, VIP
4parkinson's disease30.0PDYN, NRTN, CYP2D7P1, TAC1
5gastroparesis30.0HTR4, MLNR, MLN
6obesity30.0ADRA2A, AQP7, MLN, PYY
7cystic fibrosis30.0AQP3, CLCN2, VIP
8neuropathy30.0TAC1
9dyspepsia29.6MLN, MLNR
10diabetes mellitus29.6TAC1, PYY, MLN
11schizophrenia29.6AQP4, TDO2, ADRA2A, TAC1, HTR4, PDYN
12inflammatory bowel disease29.6TAC1
13fecal incontinence10.5
14megacolon10.3
15rectal prolapse10.3
16intestinal obstruction10.2
17proctitis10.1
18infant botulism10.1
19celiac disease10.1
20outlet dysfunction constipation10.1
21intestinal pseudo-obstruction10.1
22spina bifida10.1
23colorectal cancer10.1
24neurologic diseases10.1
25coarse face hypotonia constipation10.1
26fg syndrome10.0
27primary hyperparathyroidism10.0
28cerebritis10.0
29neuronitis10.0
30colonic pseudo-obstruction10.0
31colonic disease10.0
32porphyria10.0
33prostatitis10.0
34hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.0
35ileus10.0MLNR, MLN
36gallbladder disease10.0PYY, MLN, MLNR
37functional colonic disease10.0HTR4, MLNR
38gastrointestinal system disease10.0MLN, PYY, HTR4
39cholera10.0PYY, TAC1, VIP, ADRA2A
40colon adenocarcinoma10.0VIP
41diabetic autonomic neuropathy10.0MLNR
42nephrogenic diabetes insipidus10.0AQP7, AQP4, AQP3
43pain agnosia10.0TAC1, PDYN, CYP2D7P1
44dumping syndrome10.0MLN, PYY
45pheochromocytoma10.0VIP, PYY, PDYN, MLN
46neuroendocrine tumor10.0VIP, PYY, TAC1
47adenocarcinoma10.0AQP4, AQP3, ADRA2A, TAC1, PYY, VIP
48ulcerative colitis10.0VIP, TAC1, TACR2, MLN
49duodenogastric reflux10.0MLN
50carcinoid syndrome10.0VIP, TAC1, PYY

Graphical network of the top 20 diseases related to Constipation:



Diseases related to constipation

Clinical Features for Constipation

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Drugs & Therapeutics for Constipation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Constipation

Drug clinical trials:

Search ClinicalTrials for Constipation

Search NIH Clinical Center for Constipation

Search CenterWatch for Constipation

Genetic Tests for Constipation

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Anatomical Context for Constipation

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Sources:
32MalaCards
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MalaCards organs/tissues related to Constipation:

32
Colon, Kidney, Testes, Ovary, Prostate, Small intestine, Spinal cord, Smooth muscle, Heart, Brain, Spleen

Animal Models for Constipation or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Constipation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.3AQP4, TDO2, ADRA2A, PYY, NRTN, ISL2
2MP:000538610.2AQP4, VIP, PYY, PDYN, HTR4, NRTN
3MP:000537610.0AQP4, AQP3, TDO2, ADRA2A, CLCN2, HTR4

Publications for Constipation

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Sources:
50PubMed
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Articles related to Constipation:

(show top 50)    (show all 689)
idTitleAuthorsYear
1
Lubiprostone : pharmacokinetic, pharmacodynamic, safety and regulatory aspects in the treatment of constipation-predominant irritable bowel syndrome. (24387275)
2014
2
Prophylactic Use of a Probiotic in the Prevention of Colic, Regurgitation, and Functional Constipation: A Randomized Clinical Trial. (24424513)
2014
3
Effect of prucalopride on symptoms of chronic constipation. (24106924)
2014
4
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
5
Impact of persistent constipation on health-related quality of life and mortality in older community-dwelling women. (23670115)
2013
6
How can we achieve relief of bowel and abdominal symptoms for patients with irritable bowel syndrome with constipation? (23859757)
2013
7
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis. (23752879)
2013
8
83-year-old man with nausea, constipation, and peripheral neuropathy. (24001494)
2013
9
High-resolution colonic manometry accurately predicts colonic neuromuscular pathological phenotype in pediatric slow transit constipation. (23030503)
2013
10
Role of preoperative bowel preparation before sacral nerve modulation for constipation. (23711223)
2013
11
Is history enough to rule out significant constipation? (23337192)
2013
12
Treatment of constipation in older people. (23359042)
2013
13
Perforation and mortality after cleansing enema for acute constipation are not rare but are preventable. (23658492)
2013
14
Chronic Functional Constipation in Children: Adherence and Factors Associated to Drug Treatment. (24345842)
2013
15
Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial. (23561636)
2013
16
The effect of pelvic physiotherapy on reduction of functional constipation in children: design of a multicentre randomised controlled trial. (23914827)
2013
17
Diagnostic testing for dyssynergic defecation in chronic constipation: meta-analysis. (23421551)
2013
18
Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome. (24041540)
2013
19
Trajectory of medication-induced constipation in patients with cancer. (23615153)
2013
20
Constipation and aspiration pneumonia. (22712814)
2012
21
Constipation is a major complication after posterior sagittal anorectoplasty for anorectal malformations in children. (22964283)
2012
22
Value of abdominal radiography, colonic transit time, and rectal ultrasound scanning in the diagnosis of idiopathic constipation in children: a systematic review. (22341242)
2012
23
Factors associated with persistent and nonpersistent chronic constipation, over 20 years. (22289877)
2012
24
Clinical observation of a modified surgical method: posterior vaginal mesh suspension of female rectocele with intractable constipation. (23084670)
2012
25
Response to editorial comment to effect of constipation on serum total prostate-specific antigen levels in men. (22429286)
2012
26
Opiate-induced constipation related to activation of small intestine opioid I12-receptors. (22493554)
2012
27
Validity and reliability of the Italian Constipation Assessment Scale. (22885963)
2012
28
Burden of constipation-predominant irritable bowel syndrome (IBS-C) in France, Italy, and the United Kingdom. (23162373)
2012
29
Functional outcome of sacral nerve stimulation in patients with severe constipation. (22810473)
2012
30
Chronic constipation in hypercalcemic patients with primary hyperparathyroidism. (22953636)
2012
31
Pharmacological management of chronic constipation in older adults. (22420516)
2012
32
Postoperative constipation risk assessment in Turkish orthopedic patients. (22472670)
2012
33
Practical treatments for constipation in Korea. (23019388)
2012
34
Safety evaluation of lubiprostone in the treatment of constipation and irritable bowel syndrome. (22834474)
2012
35
Cross-sectional study on relationship between constipation and medication in consideration of sleep disorder. (21804327)
2011
36
Prevalence and pathophysiology of functional constipation among women in Catalonia, Spain. (22067186)
2011
37
A controlled trial of an intervention to improve urinary and fecal incontinence and constipation. (20653804)
2010
38
Lubiprostone: chronic constipation and irritable bowel syndrome with constipation. (19236188)
2009
39
Editorial comment re: Sacral nerve stimulation for fecal incontinence and constipation in adults: a short version Cochrane review. (18314864)
2008
40
Multidisciplinary behavioural treatment of fecal incontinence and constipation after correction of anorectal malformation. (18822930)
2008
41
Experience of acetylcholinesterase histochemistry application in the diagnosis of chronic constipation in children. (17563414)
2007
42
Colorectal motor and sensitivity features in patients affected by ulcerative proctitis with constipation: a radiological and manometric controlled study. (16917226)
2006
43
An association of multiple endocrine neoplasia 2B, a RET mutation; constipation; and low substance P-nerve fiber density in colonic circular muscle. (16481266)
2006
44
Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome. (16696817)
2006
45
Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation. (15688149)
2005
46
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. (16048580)
2005
47
Idiopathic chronic constipation: tachykinins as cotransmitters in colonic contraction. (11298783)
2001
48
Abnormalities of nerve fibers in the circular muscle of patients with slow transit constipation. (9870163)
1998
49
Anterior sacral meningocele: an uncommon cause of constipation in early childhood. (1452316)
1992
50
Subtotal colectomy for treatment of chronic constipation associated with idiopathic megacolon in cats: 38 cases (1979-1985). (3192467)
1988

Genetic Variations for Constipation

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Expression for genes affiliated with Constipation

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Constipation

Search GEO for disease gene expression data for Constipation.

Pathways for genes affiliated with Constipation

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Constipation

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Constipation according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1phentolamine28 44 1112.8ADRA2A, TAC1, VIP, PYY
2kassinin28 4411.8TACR2, TAC1, TAC3
3spantide4410.8TACR2, TAC1, PDYN, VIP
4thiorphan44 28 1112.8TAC3, VIP, TACR2, TAC1
5eledoisin44 2811.8TAC3, TAC1, TACR2
6septide44 2811.8TACR2, TAC3, TAC1
7gnrh4410.8HTR4, TAC3, PDYN, PYY, VIP
8senktide44 59 2812.8TACR2, TAC3, TAC1
9capsaicin44 2811.8VIP, TAC1, TACR2, PDYN, TAC3
10hexamethonium44 2811.8VIP, PYY, TACR2
11phosphoramidon44 1111.8PDYN, VIP, TACR2, TAC1
126-hydroxydopamine4410.8PDYN, NRTN, TAC1, VIP
13tetrodotoxin44 59 2812.8PYY, MLN, TAC1, TAC3, TACR2, VIP
14aequorin4410.8TAC1, MLN, MLNR
15chloride4410.8VIP, TAC1, AQP3, AQP4, CLCN2, TACR2
16guanethidine44 1111.8VIP, TAC1, TACR2
17bestatin44 28 59 1113.8PDYN, TAC1, TAC3
18oxyntomodulin44 5911.8VIP, MLN, PYY
195-hydroxytryptamine4410.8MLN, TDO2, PYY, TACR2, TAC1, VIP
20mepyramine44 1111.8TAC1, TAC3, TACR2
21cisapride44 28 1112.8MLNR, MLN, HTR4
22atropine44 28 1112.8HTR4, PDYN, TAC3, TACR2, PYY, VIP
23dopamine44 28 11 2413.8TAC1, ADRA2A, TAC3, NRTN, MLN, MLNR
24acth4410.8PDYN, PYY, MLN, HTR4, VIP
25histamine44 28 2412.8TACR2, TAC1, VIP, MLN, AQP4, PYY
26acetylcholine44 49 28 11 2414.8MLN, NRTN, TAC1, TACR2, TAC3, VIP
27cyclo(gln-trp-phe-gly-leu-met)4410.7TAC1, TACR2
28ondansetron44 49 11 2413.7HTR4, MLN, TAC1
29nepadutant44 2811.7TACR2, TAC1
30[lys5,meleu9,nle10]-nka(4-10)5910.7TAC1, TACR2
31glutamate4410.7TACR2, TAC1, AQP4, NRTN, HTR4, VIP
32gr 948005910.7TAC1, TACR2
33arginine4410.7TDO2, TACR2, TAC1, MLN, HTR4, PDYN
34gr 643495910.7TACR2, TAC1
35gr 1598975910.7TAC1, TACR2
36adenylate4410.7PDYN, AQP3, TAC1, MLN, VIP, ADRA2A
37men 1037644 59 2812.7TAC1, TACR2
38tyrosine4410.7ADRA2A, NRTN, VIP, PYY, PDYN, TDO2
39norepinephrine44 11 2412.6PDYN, VIP, TAC1, ADRA2A, PYY
40gr 712514410.6TAC1, TACR2
41nifedipine44 49 28 1113.6MLN, VIP, TAC1, TACR2
42cp 963454410.6TACR2, TAC1
43em 5234410.6MLNR, MLN
44yohimbine44 28 2 1113.6PYY, HTR4, ADRA2A
45carbachol44 28 1112.5TAC1, TAC3, VIP, PYY
46omeprazole44 28 49 11 2414.5CLCN2, MLN, PYY
47physalaemin44 2811.4TAC3, TAC1
48potassium44 11 2412.4VIP, TACR2, PDYN, TAC1, AQP4
49prucalopride44 2811.3MLN, HTR4
50gr 823344410.1TACR2, TAC1

GO Terms for genes affiliated with Constipation

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16Gene Ontology
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Cellular components related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00591110.4AQP7, AQP4, AQP3
2extracellular regionGO:00557610.3TAC3, VIP, PYY, PDYN, MLN, NRTN
3plasma membraneGO:00588610.2PDYN, HTR4, MLNR, CLCN2, TAC1, TACR2
4integral to plasma membraneGO:00588710.1HTR4, MLNR, TACR2, ADRA2A, AQP4, AQP7

Biological processes related to Constipation according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1renal water absorptionGO:07029510.6AQP3, AQP4, AQP7
2excretionGO:00758810.5AQP4, AQP3, TACR2, AQP7
3tachykinin receptor signaling pathwayGO:00721710.5TACR2, TAC3, TAC1
4neuropeptide signaling pathwayGO:00721810.4PDYN, TAC1, TAC3
5G-protein coupled receptor signaling pathwayGO:00718610.4PYY, HTR4, MLNR, MLN, ADRA2A, VIP
6water transportGO:00683310.3AQP7, AQP3, AQP4
7female pregnancyGO:00756510.1ADRA2A, TAC3, AQP4

Molecular functions related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.5PYY, VIP
2water channel activityGO:01525010.3AQP7, AQP3
3hormone activityGO:00517910.1MLN, PYY, VIP

Products for genes affiliated with Constipation

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  • Antibodies
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Sources for Constipation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet