MCID: CNS004
MIFTS: 53

Constipation malady

Gastrointestinal diseases category
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Summaries for Constipation

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Constipation means that a person has three or fewer bowel movements in a week. the stool can be hard and dry. sometimes it is painful to pass. at one time or another, almost everyone gets constipated. in most cases, it lasts a short time and is not serious. there are many things you can do to prevent constipation. they include eating more fruits, vegetables and grains, which are high in fiber drinking plenty of water and other liquids getting enough exercise taking time to have a bowel movement when you need to using laxatives only if your doctor says you should asking your doctor if medicines you take may cause constipation it's not important that you have a bowel movement every day. if your bowel habits change, however, check with your doctor. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Constipation is related to hirschsprung's disease and diarrhea. An important gene associated with Constipation is CLCN2 (chloride channel, voltage-sensitive 2), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Peptide ligand-binding receptors. The compounds thiorphan and captopril have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and testes, and related mouse phenotypes are vision/eye and normal.

Wikipedia:65 Constipation (also known as costiveness or dyschezia) refers to bowel movements that are infrequent or... more...

Aliases & Classifications for Constipation

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Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 58SNOMED-CT, 27ICD9CM, 35MeSH, 62UMLS, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

constipation 8 10 34


External Ids:

Disease Ontology8 DOID:2089
ICD9CM27 564.0, 564.00
MeSH35 D003248
NCIt40 C37930
ICD1025 K59.0

Related Diseases for Constipation

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Constipation:



Diseases related to constipation

Symptoms for Constipation

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Drugs & Therapeutics for Constipation

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Constipation

Search NIH Clinical Center for Constipation

Genetic Tests for Constipation

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Anatomical Context for Constipation

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Sources:
33MalaCards
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MalaCards organs/tissues related to Constipation:

33
Colon, Kidney, Testes, Ovary, Small intestine, Spinal cord, Prostate, Smooth muscle, Heart, Brain, Spleen

Animal Models for Constipation or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Constipation:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8CLCN2, AQP3, NRTN, TDO2
2MP:00028738.6TAC3, ADRA2A, VIP, PYY
3MP:00036318.3TDO2, NRTN, ADRA2A, CLCN2, PYY
4MP:00053798.2CLCN2, AQP7, VIP, NRTN
5MP:00053867.0TDO2, PYY, CLCN2, AQP3, VIP, ADRA2A
6MP:00053766.9PYY, CLCN2, AQP7, AQP3, VIP, ADRA2A

Publications for Constipation

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52PubMed
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Articles related to Constipation:

(show top 50)    (show all 684)
idTitleAuthorsYear
1
Finger taps and constipation are closely related to symptoms of overactive bladder in male patients with Parkinson's disease. (23659545)
2014
2
Review article: linaclotide for the management of irritable bowel syndrome with constipation. (24433216)
2014
3
Management of faecal incontinence and constipation in adults with central neurological diseases. (24420006)
2014
4
Colonic electrical stimulation for the treatment of slow-transit constipation: a preliminary pilot study. (24048815)
2013
5
Interferential therapy: a new treatment for slow transit constipation. a pilot study in adults. (23046450)
2013
6
Clinical and psychosocial functioning in adolescents and young adults with anorectal malformations and chronic idiopathic constipation. (23553758)
2013
7
Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation. (24007408)
2013
8
Linaclotide-a novel secretagogue in the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (24001336)
2013
9
The use of prucalopride in real life for the treatment of constipation subtypes: ups and downs. (23703576)
2013
10
Association of constipation and fecal incontinence with attention-deficit/hyperactivity disorder. (24144702)
2013
11
Strumal carcinoid tumour of the ovary presenting with severe constipation. (23338927)
2013
12
In-hospital costs associated with chronic constipation in Belgium: a retrospective database study. (24325294)
2013
13
Chronic constipation. (23943571)
2013
14
The efficacy and safety study of electro-acupuncture for severe chronic functional constipation: study protocol for a multicenter, randomized, controlled trial. (23768191)
2013
15
Sacral nerve stimulation for constipation (Br J Surg 2013; 100: 174-181). (23239479)
2013
16
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
17
Impact of persistent constipation on health-related quality of life and mortality in older community-dwelling women. (23670115)
2013
18
Management of functional constipation in children with lower urinary tract symptoms: report from the Standardization Committee of the International Children's Continence Society. (23313210)
2013
19
The Self-Report Fecal Incontinence and Constipation Questionnaire in Patients With Pelvic-Floor Dysfunction Seeking Outpatient Rehabilitation. (24114438)
2013
20
The association between prucalopride efficacy and constipation type. (23703575)
2013
21
Effect of dietary fiber on constipation: a meta analysis. (23326148)
2012
22
Celiac disease is overrepresented in patients with constipation. (22434186)
2012
23
Constipation and aspiration pneumonia. (22712814)
2012
24
Re: oral docusate in the management of constipation in hospice patients. (23217455)
2012
25
Transabdominal electrical stimulation increases colonic propagating pressure waves in paediatric slow transit constipation. (23217889)
2012
26
Chronic constipation due to delayed diagnosis of a congenital anal web. (22271242)
2012
27
Constipation is a major complication after posterior sagittal anorectoplasty for anorectal malformations in children. (22964283)
2012
28
Development and assessment of the constipation-related disability scale. (22248425)
2012
29
OTC polyethylene glycol 3350 and pharmacists' role in managing constipation. (22618979)
2012
30
Multiple visits for abdominal pain, constipation, and "I need a test for sexually transmitted diseases". (23162938)
2012
31
Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation. (21585622)
2011
32
The pathophysiology of chronic constipation. (22114753)
2011
33
Chronic constipation may signify higher risk of heart disease. If you suffer from chronic constipation, see your cardiologist. (23019713)
2011
34
Managing functional constipation in children. (23204909)
2011
35
A topic in 10 questions: how to manage infant constipation. (22132562)
2011
36
Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. (20691689)
2010
37
Use of the chloride channel activator lubiprostone for constipation in adults with cystic fibrosis: a case series. (20179256)
2010
38
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
39
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
40
Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation. (15688149)
2005
41
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. (16048580)
2005
42
Pathology of chronic constipation in pediatric and adult coloproctology. (15902901)
2005
43
May chronic childhood constipation cause oxidative stress and potential free radical damage to children? (15602823)
2004
44
The constipated child: how likely is Hirschsprung's disease? (12698267)
2003
45
Chronic constipation--a lethal danger in patients with systemic scleroderma. (11785605)
2001
46
Effects of erythromycin on human colonic circular muscle in idiopathic chronic constipation. (10620004)
2000
47
Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation. (10027360)
1999
48
Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. (9129468)
1997
49
Function of the striated anal sphincter during straining in control subjects and constipated patients with a radiologically normal rectum or idiopathic megacolon. (3198990)
1988
50
Letter: Constipation: a cause of urinary tract obstruction and infection. (1246799)
1976

Variations for Constipation

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Expression for genes affiliated with Constipation

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Constipation

Search GEO for disease gene expression data for Constipation.

Pathways for genes affiliated with Constipation

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Sources:
50PathCards, 51PharmGKB, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters
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Pathways related to Constipation according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PYY, ADRA2A
2
Show member pathways
9.1ADRA2A, PYY, TAC3
3
Show member pathways
9.0AQP3, AQP7
4
Show member pathways
8.7AQP3, CLCN2, AQP7

Compounds for genes affiliated with Constipation

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Constipation according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1thiorphan45 29 1112.0VIP, TAC3
2captopril45 61 51 29 1114.0VIP, TAC3
36-hydroxydopamine4510.0VIP, NRTN
4omeprazole45 51 29 24 1114.0CLCN2, PYY
5capsaicin45 2910.9VIP, TAC3
6hexamethonium45 2910.9VIP, PYY
7oxyntomodulin45 6110.8PYY, VIP
8bromocriptine45 29 1111.8VIP, ADRA2A
9yohimbine45 3 29 1112.8ADRA2A, PYY
10amiloride45 29 1111.8ADRA2A, VIP
11octreotide45 61 29 1112.7VIP, PYY
12clonidine45 51 29 1112.7ADRA2A, PYY
13phenylephrine45 29 24 1112.7ADRA2A, VIP
14propranolol45 29 51 24 1113.6VIP, PYY
15melatonin45 29 61 24 1113.6TDO2, VIP
16ornithine45 2410.5TDO2, PYY
17atropine45 29 1111.5TAC3, VIP, PYY
18choline45 24 1111.5VIP, ADRA2A, NRTN
19tetrodotoxin45 61 2911.5PYY, VIP, TAC3
20carbachol45 29 1111.5PYY, VIP, TAC3
215-hydroxytryptamine459.5TDO2, VIP, PYY
22chloride459.4VIP, AQP3, CLCN2
23hg2+299.4AQP3, AQP7
24haloperidol45 51 29 3 1113.4PYY, VIP
25phentolamine45 29 1111.4ADRA2A, VIP, PYY
26isoproterenol45 1110.3ADRA2A, VIP, PYY
27norepinephrine45 24 1111.3PYY, VIP, ADRA2A
28aspartate459.3VIP, ADRA2A, TDO2
29catecholamine459.2ADRA2A, VIP
30acetylcholine45 51 29 24 1113.2PYY, VIP, NRTN, TAC3
31cyclic amp45 2410.0ADRA2A, VIP, PYY
32gnrh459.0TAC3, ADRA2A, VIP, PYY
33adenylate459.0AQP3, VIP, ADRA2A
34estrogen458.9TAC3, ADRA2A, VIP, PYY
35forskolin45 51 1110.9VIP, AQP3, AQP7
36dopamine45 29 24 1111.7PYY, VIP, ADRA2A, NRTN, TAC3
37tyrosine458.2PYY, VIP, ADRA2A, NRTN, TAC3, TDO2

GO Terms for genes affiliated with Constipation

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16Gene Ontology
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Cellular components related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:0059119.0AQP3, AQP7
2extracellular regionGO:0055768.5TAC3, NRTN, VIP, PYY

Biological processes related to Constipation according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:0459099.6VIP, ADRA2A
2female pregnancyGO:0075659.5ADRA2A, TAC3
3cellular component movementGO:0069289.4ADRA2A, PYY
4renal water absorptionGO:0702959.2AQP7, AQP3
5water transportGO:0068339.1AQP3, AQP7
6G-protein coupled receptor signaling pathwayGO:0071869.1ADRA2A, VIP, PYY
7excretionGO:0075889.0AQP3, AQP7
8transmembrane transportGO:0550858.4AQP7, CLCN2, AQP3

Molecular functions related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5VIP, PYY
2neuropeptide hormone activityGO:0051849.2VIP, PYY
3water channel activityGO:0152508.9AQP3, AQP7

Products for genes affiliated with Constipation

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Sources for Constipation

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet