MCID: CNS004
MIFTS: 50

Constipation malady

Gastrointestinal category

Summaries for Constipation

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Constipation means that a person has three or fewer bowel movements in a week. the stool can be hard and dry. sometimes it is painful to pass. at one time or another, almost everyone gets constipated. in most cases, it lasts a short time and is not serious. there are many things you can do to prevent constipation. they include eating more fruits, vegetables and grains, which are high in fiber drinking plenty of water and other liquids getting enough exercise taking time to have a bowel movement when you need to using laxatives only if your doctor says you should asking your doctor if medicines you take may cause constipation it's not important that you have a bowel movement every day. if your bowel habits change, however, check with your doctor. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Constipation is related to irritable bowel syndrome and hirschsprung's disease. An important gene associated with Constipation is CLCN2 (chloride channel, voltage-sensitive 2), and among its related pathways are Regulation of Water Balance by Renal Aquaporins and Passive Transport by Aquaporins. The compounds phentolamine and kassinin have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:64 Constipation (also known as costiveness or dyschezia) refers to bowel movements that are infrequent or... more...

Aliases & Classifications for Constipation

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 57SNOMED-CT, 35MeSH, 27ICD9CM, 61UMLS, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

constipation 8 10 34


External Ids:

Disease Ontology8 DOID:2089
MeSH35 D003248
ICD9CM27 564.00, 564.0
NCIt40 C37930
ICD1025 K59.0

Related Diseases for Constipation

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Constipation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome31.0HTR4, MLN, TAC1
2hirschsprung's disease30.4TAC1, NRTN, VIP
3ileus30.1MLN, MLNR
4gastroparesis30.0MLN, MLNR, HTR4
5cystic fibrosis30.0VIP, CLCN2, AQP3
6serotonin syndrome30.0TAC1, PYY
7parkinson's disease29.9PDYN, NRTN, CYP2D7P1, TAC1
8dyspepsia29.7MLN, MLNR
9fecal incontinence10.6
10rectal prolapse10.3
11n syndrome10.2
12hypotonia10.2
13proctitis10.1
14infant botulism10.1
15celiac disease10.1
16outlet dysfunction constipation10.1
17spina bifida10.1
18colorectal cancer10.1
19neurologic diseases10.1
20coarse face hypotonia constipation10.1
21chronic pain10.1
22primary hyperparathyroidism10.0
23colonic pseudo-obstruction10.0
24myelomeningocele10.0
25hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.0
26gallbladder disease10.0MLN, MLNR, PYY
27functional colonic disease10.0HTR4, MLNR
28diarrhea10.0VIP, PYY, MLN, TAC1
29gastrointestinal system disease10.0MLN, HTR4, PYY
30cholera10.0ADRA2A, TAC1, PYY, VIP
31colon adenocarcinoma10.0VIP
32diabetic autonomic neuropathy10.0MLNR
33obesity10.0AQP7, ADRA2A, MLN, PYY
34nephrogenic diabetes insipidus10.0AQP7, AQP4, AQP3
35pain agnosia10.0TAC1, CYP2D7P1, PDYN
36dumping syndrome10.0PYY, MLN
37pheochromocytoma10.0VIP, PYY, PDYN, MLN
38neuroendocrine tumor10.0TAC1, PYY, VIP
39adenocarcinoma10.0VIP, PYY, TAC1, ADRA2A, AQP3, AQP4
40ulcerative colitis10.0VIP, MLN, TAC1, TACR2
41duodenogastric reflux10.0MLN
42carcinoid syndrome10.0TAC1, PYY, VIP
43anorexia nervosa10.0PYY
44ischemia10.0VIP, PDYN, MLN, AQP4
45hypertrophy of breast10.0TAC3, PDYN, PYY, VIP
46hydrocephalus10.0AQP4
47asthma10.0TACR2, TAC1, VIP
48diabetes mellitus10.0TAC1, MLN, PYY
49chronic fatigue syndrome10.0VIP
50alzheimer's disease10.0PYY, PDYN, AQP4

Graphical network of the top 20 diseases related to Constipation:



Diseases related to constipation

Clinical Features for Constipation

Drugs & Therapeutics for Constipation

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Constipation

Drug clinical trials:

Search ClinicalTrials for Constipation

Search NIH Clinical Center for Constipation

Search CenterWatch for Constipation

Genetic Tests for Constipation

Anatomical Context for Constipation

Animal Models for Constipation or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Constipation:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.3PDYN, HTR4, ISL2, NRTN, CLCN2, ADRA2A
2MP:000538610.2AQP4, VIP, PYY, PDYN, HTR4, NRTN
3MP:000537610.0HTR4, PDYN, PYY, VIP, CLCN2, ADRA2A

Publications for Constipation

Sources:
51PubMed
See all sources

Articles related to Constipation:

(show top 50)    (show all 680)
idTitleAuthorsYear
1
Irritable Bowel Syndrome subtypes: constipation, diarrheaa8 (24329945)
nd mixed bow
2
Constipation associated with brumation? Intestinal obstruction caused by a fecalith in a wild red diamond rattlesnake (Crotalus ruber). (23398054)
2014
3
Interferential therapy: a new treatment for slow transit constipation. a pilot study in adults. (23046450)
2013
4
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
5
Impact of persistent constipation on health-related quality of life and mortality in older community-dwelling women. (23670115)
2013
6
How can we achieve relief of bowel and abdominal symptoms for patients with irritable bowel syndrome with constipation? (23859757)
2013
7
Elobixibat for the treatment of constipation. (23215781)
2013
8
Clinical examination remains more important than anorectal function tests to identify treatable conditions in women with constipation. (22618205)
2013
9
Development of an early nurse led intervention to treat children referred to secondary paediatric care with constipation with or without soiling. (24252503)
2013
10
Health-related quality of life in dialysis patients with constipation: a cross-sectional study. (23814466)
2013
11
A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation. (23726675)
2013
12
Enhancement of antinociception but not constipation by combinations containing tramadol and metamizole in arthritic rats. (24054996)
2013
13
Absolute constipation caused by sigmoid volvulus in a young man. (23744852)
2013
14
Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (23090647)
2013
15
Sacral nerve stimulation for constipation. (23124687)
2013
16
Primary Care Management of Chronic Constipation in Asia: The ANMA Chronic Constipation Tool. (23667746)
2013
17
A prospective study of methylnaltrexone for opioid-induced constipation in advanced illness: should we use it or not? (24176612)
2013
18
Management of chronic constipation in general practice. (24272606)
2013
19
Cochrane Review: Osmotic and stimulant laxatives for the management of childhood constipation (Review). (23878124)
2013
20
Preschool physical activity and functional constipation: the Generation R study. (23857342)
2013
21
Quality of life and somatic symptoms in children with constipation: a school-based study. (23800401)
2013
22
Poststroke constipation in the rehabilitation ward: incidence, clinical course and associated factors. (24276098)
2013
23
Functional constipation in children: the pediatric surgeon's perspective. (23913262)
2013
24
An unusual cause of constipation in a 72-year-old man with a rising creatinine. (23897380)
2013
25
Optimizing treatment for patients with irritable bowel syndrome with constipation. (23859753)
2013
26
Effects of a probiotic fermented milk on functional constipation: a randomized, double-blind, placebo-controlled study. (23432408)
2013
27
Estrogen rather than progesterone cause constipation in both female and male mice. (24227943)
2013
28
Don't forget about constipation with opioid treatment of chronic non-cancer pain. (23861421)
2013
29
Effect of dietary fiber on constipation: a meta analysis. (23326148)
2012
30
Constipation is a major complication after posterior sagittal anorectoplasty for anorectal malformations in children. (22964283)
2012
31
Response to "A cross-sectional study of constipation and laxative use in advanced cancer patients: insights for revision of current practise". (23010960)
2012
32
Single-incision laparoscopic ileoproctostomy for chronic constipation. (22251529)
2012
33
Stimulant laxatives and opioid-induced constipation. (22248790)
2012
34
Linaclotide: evidence for its potential use in irritable bowel syndrome and chronic constipation. (22807692)
2012
35
How to manage chronic constipation in adults. (23252099)
2012
36
Management of opioid-induced constipation in cancer patients: focus on methylnaltrexone. (22413747)
2012
37
Chronic constipation may signify higher risk of heart disease. If you suffer from chronic constipation, see your cardiologist. (23019713)
2011
38
A unique approach to severe constipation. (22263442)
2011
39
Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents. (20137076)
2010
40
Constipation is associated with spina bifida occulta in children. (19081525)
2008
41
Lubiprostone for constipation and irritable bowel syndrome with constipation. (19090733)
2008
42
Histochemical staining of rectal suction biopsies as the first investigation in patients with chronic constipation. (18463882)
2008
43
Peptide YY producing strumal carcinoid of the ovary as the cause of severe constipation with contralateral epithelial ovarian cancer. (17578375)
2007
44
Enteric neuropathology of the terminal ileum in patients with intractable slow-transit constipation. (16949932)
2006
45
Cauda equina syndrome secondary to constipation: an uncommon occurrence. (15943746)
2005
46
Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients. (15719424)
2005
47
Chronic constipation due to Hirschsprung's disease and desmosis coli in a family. (11956774)
2002
48
FG syndrome: the trias mental retardation, hypotonia and constipation reviewed. (8775418)
1995
49
Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease. (1696228)
1990
50
Morphological findings of chronic constipation in childhood]. (934118)
1976

Genetic Variations for Constipation

Expression for genes affiliated with Constipation

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Constipation

Search GEO for disease gene expression data for Constipation.

Pathways for genes affiliated with Constipation

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Constipation

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Constipation according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1phentolamine29 45 1112.8ADRA2A, TAC1, VIP, PYY
2kassinin29 4511.8TACR2, TAC1, TAC3
3spantide4510.8TACR2, TAC1, PDYN, VIP
4thiorphan45 29 1112.8TAC3, VIP, TACR2, TAC1
5eledoisin45 2911.8TAC3, TAC1, TACR2
6septide45 2911.8TACR2, TAC3, TAC1
7gnrh4510.8HTR4, TAC3, PDYN, PYY, VIP
8senktide45 60 2912.8TACR2, TAC3, TAC1
9capsaicin45 2911.8VIP, TAC1, TACR2, PDYN, TAC3
10hexamethonium45 2911.8VIP, PYY, TACR2
11phosphoramidon45 1111.8PDYN, VIP, TACR2, TAC1
126-hydroxydopamine4510.8PDYN, NRTN, TAC1, VIP
13tetrodotoxin45 60 2912.8PYY, MLN, TAC1, TAC3, TACR2, VIP
14aequorin4510.8TAC1, MLN, MLNR
15chloride4510.8VIP, TAC1, AQP3, AQP4, CLCN2, TACR2
16guanethidine45 1111.8VIP, TAC1, TACR2
17bestatin45 29 60 1113.8PDYN, TAC1, TAC3
18oxyntomodulin45 6011.8VIP, MLN, PYY
195-hydroxytryptamine4510.8MLN, TDO2, PYY, TACR2, TAC1, VIP
20mepyramine45 1111.8TAC1, TAC3, TACR2
21cisapride45 29 1112.8MLNR, MLN, HTR4
22atropine45 29 1112.8HTR4, PDYN, TAC3, TACR2, PYY, VIP
23dopamine45 29 11 2413.8TAC1, ADRA2A, TAC3, NRTN, MLN, MLNR
24acth4510.8PDYN, PYY, MLN, HTR4, VIP
25histamine45 29 2412.8TACR2, TAC1, VIP, MLN, AQP4, PYY
26acetylcholine45 50 29 11 2414.8MLN, NRTN, TAC1, TACR2, TAC3, VIP
27cyclo(gln-trp-phe-gly-leu-met)4510.7TAC1, TACR2
28ondansetron45 50 11 2413.7HTR4, MLN, TAC1
29nepadutant45 2911.7TACR2, TAC1
30[lys5,meleu9,nle10]-nka(4-10)6010.7TAC1, TACR2
31glutamate4510.7TACR2, TAC1, AQP4, NRTN, HTR4, VIP
32gr 948006010.7TAC1, TACR2
33arginine4510.7TDO2, TACR2, TAC1, MLN, HTR4, PDYN
34gr 643496010.7TACR2, TAC1
35gr 1598976010.7TAC1, TACR2
36adenylate4510.7PDYN, AQP3, TAC1, MLN, VIP, ADRA2A
37men 1037645 60 2912.7TAC1, TACR2
38tyrosine4510.7ADRA2A, NRTN, VIP, PYY, PDYN, TDO2
39norepinephrine45 11 2412.6PDYN, VIP, TAC1, ADRA2A, PYY
40gr 712514510.6TAC1, TACR2
41nifedipine45 50 29 1113.6MLN, VIP, TAC1, TACR2
42cp 963454510.6TACR2, TAC1
43em 5234510.6MLNR, MLN
44yohimbine45 29 2 1113.6PYY, HTR4, ADRA2A
45carbachol45 29 1112.5TAC1, TAC3, VIP, PYY
46omeprazole45 29 50 11 2414.5CLCN2, MLN, PYY
47physalaemin45 2911.4TAC3, TAC1
48potassium45 11 2412.4VIP, TACR2, PDYN, TAC1, AQP4
49prucalopride45 2911.3MLN, HTR4
50gr 823344510.1TACR2, TAC1

GO Terms for genes affiliated with Constipation

Sources:
16Gene Ontology
See all sources

Cellular components related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00591110.4AQP7, AQP4, AQP3
2extracellular regionGO:00557610.3TAC3, VIP, PYY, PDYN, MLN, NRTN
3plasma membraneGO:00588610.2PDYN, HTR4, MLNR, CLCN2, TAC1, TACR2
4integral to plasma membraneGO:00588710.1HTR4, MLNR, TACR2, ADRA2A, AQP4, AQP7

Biological processes related to Constipation according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1renal water absorptionGO:07029510.6AQP7, AQP4, AQP3
2excretionGO:00758810.5TACR2, AQP3, AQP4, AQP7
3tachykinin receptor signaling pathwayGO:00721710.5TACR2, TAC3, TAC1
4neuropeptide signaling pathwayGO:00721810.4TAC3, TAC1, PDYN
5G-protein coupled receptor signaling pathwayGO:00718610.4VIP, PYY, HTR4, MLNR, MLN, ADRA2A
6water transportGO:00683310.3AQP7, AQP4, AQP3
7female pregnancyGO:00756510.1TAC3, ADRA2A, AQP4

Molecular functions related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.5PYY, VIP
2water channel activityGO:01525010.3AQP7, AQP3
3hormone activityGO:00517910.1MLN, PYY, VIP

Products for genes affiliated with Constipation

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Sources for Constipation

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet