MCID: CNS004
MIFTS: 57

Constipation malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Constipation

Summaries for Constipation

MedlinePlus : 41 constipation means that a person has three or fewer bowel movements in a week. the stool can be hard and dry. sometimes it is painful to pass. at one time or another, almost everyone gets constipated. in most cases, it lasts a short time and is not serious. there are many things you can do to prevent constipation. they include eating more fruits, vegetables and grains, which are high in fiber drinking plenty of water and other liquids getting enough exercise taking time to have a bowel movement when you need to using laxatives only if your doctor says you should asking your doctor if medicines you take may cause constipation it's not important that you have a bowel movement every day. if your bowel habits change, however, check with your doctor. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Constipation is related to hirschsprung disease 1 and rickets. An important gene associated with Constipation is HTR3A (5-Hydroxytryptamine Receptor 3A), and among its related pathways/superpathways are Peptide ligand-binding receptors and Signaling by GPCR. The drugs Methylnaltrexone and Naltrexone have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and testes, and related phenotypes are Decreased viability and behavior/neurological

Disease Ontology : 12 A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces.

Wikipedia : 71 Constipation refers to bowel movements that are infrequent or hard to pass. The stool is often hard and... more...

Related Diseases for Constipation

Diseases related to Constipation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
id Related Disease Score Top Affiliating Genes
1 hirschsprung disease 1 31.1 EDNRB GDNF RET
2 rickets 30.8 CCK FLNA NTS PYY SST
3 typhoid fever 30.5 CCK GAST HTR3A SST TAC1
4 chagas disease 29.2 CCK HTR3A PYY SLC6A4
5 autism spectrum disorder 29.1 CCK OPRM1 SLC6A4 TAC1
6 outlet dysfunction constipation 12.0
7 coarse face hypotonia constipation 11.8
8 irritable bowel syndrome 11.2
9 fecal incontinence 11.1
10 porphyria 11.1
11 intestinal pseudo-obstruction 11.0
12 caudal regression syndrome 11.0
13 colonic pseudo-obstruction 10.9
14 colorectal cancer 10.9
15 hemorrhoid 10.9
16 intestinal obstruction 10.9
17 hypoganglionosis 10.9
18 ulcerative proctitis 10.9
19 multiple system atrophy 10.9
20 disseminated peritoneal leiomyomatosis 10.9
21 celiac disease 10.9
22 pitt-hopkins syndrome 10.9
23 fg syndrome 4 10.7
24 opitz-kaveggia syndrome 10.7
25 fg syndrome 2 10.7
26 urofacial syndrome 1 10.7
27 tarlov cysts 10.7
28 neuropathy, hereditary sensory and autonomic, type vii 10.7
29 urofacial syndrome 2 10.5
30 diverticulitis 10.5
31 central hypoventilation syndrome, congenital 10.5
32 osmotic diarrhea 10.5
33 multiple system atrophy with orthostatic hypotension 10.5
34 parkinson disease, late-onset 10.5
35 pelvic lipomatosis 10.5
36 ogilvie syndrome 10.5
37 acanthocephaliasis 10.5
38 appendicitis 10.5
39 sacral nerve root cysts 10.5
40 hyperparathyroidism, familial primary 10.5
41 peroxisome biogenesis disorder 8b 10.5
42 polyposis, juvenile intestinal 10.5
43 infant botulism 10.5
44 autoimmune autonomic ganglionopathy 10.5
45 pure autonomic failure 10.5
46 pitt-hopkins-like syndrome 2 10.5
47 benign multicystic peritoneal mesothelioma 10.5
48 paroxysmal extreme pain disorder 10.5
49 adiposis dolorosa 10.5
50 intestinal volvulus 10.5

Graphical network of the top 20 diseases related to Constipation:



Diseases related to Constipation

Symptoms & Phenotypes for Constipation

GenomeRNAi Phenotypes related to Constipation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 HTR3A MLN SLC6A4
2 Decreased viability GR00381-A-3 9.1 HTR3A MLN SLC6A4

MGI Mouse Phenotypes related to Constipation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.39 TAC1 TACR1 VIP CCK CLCN2 EDNRB
2 homeostasis/metabolism MP:0005376 10.16 PYY RET SLC6A4 SST TACR1 VIP
3 cardiovascular system MP:0005385 10.13 VIP CLCN2 EDNRB FLNA GDNF KIT
4 endocrine/exocrine gland MP:0005379 10.11 RET SLC6A4 VIP CCK CLCN2 EDNRB
5 growth/size/body region MP:0005378 10.1 EDNRB FLNA GDNF HTR3A HTR4 KIT
6 digestive/alimentary MP:0005381 10.06 CLCN2 EDNRB FLNA GAST GDNF KIT
7 immune system MP:0005387 9.93 FLNA GAST GDNF HTR3A KIT OPRM1
8 nervous system MP:0003631 9.83 CCK CLCN2 EDNRB FLNA GDNF HTR3A
9 normal MP:0002873 9.28 FLNA KIT OPRM1 PYY RET SLC6A4

Drugs & Therapeutics for Constipation

Drugs for Constipation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 530)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylnaltrexone Approved Phase 4,Phase 3,Phase 2 83387-25-1, 916055-93-1 6603824
2
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 16590-41-3 5360515
3
Lubiprostone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 136790-76-6 656719
4
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2 465-65-6 5284596
5
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 76-42-6 5284603
6
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
7
Oxybutynin Approved, Investigational Phase 4,Phase 3 5633-20-5 4634
8
Amitriptyline Approved Phase 4 50-48-6 2160
9
Cyclobenzaprine Approved Phase 4 303-53-7 2895
10
Ropivacaine Approved Phase 4,Phase 3,Phase 2 84057-95-4 71273 175805
11
Bisacodyl Approved Phase 4,Phase 3,Phase 2 603-50-9
12
Lactulose Approved Phase 4,Phase 3,Phase 2,Phase 1 4618-18-2 11333
13
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
15
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
16
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
17
Loperamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53179-11-6 3955
18
Magnesium oxide Approved Phase 4,Phase 2 1309-48-4 14792
19
Bismuth Subsalicylate Approved, Vet_approved Phase 4,Phase 3,Phase 2 14882-18-9 53629521
20
Magnesium Hydroxide Approved Phase 4,Phase 2 1309-42-8
21
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
22
Sorbitol Approved Phase 4,Phase 3 50-70-4 5780
23
Celecoxib Approved, Investigational Phase 4,Phase 1 169590-42-5 2662
24
Hydromorphone Approved, Illicit Phase 4,Phase 2,Phase 3 466-99-9 5284570
25
Ibuprofen Approved Phase 4,Phase 1 15687-27-1 3672
26
Ondansetron Approved Phase 4 99614-02-5 4595
27
Octreotide Approved, Investigational Phase 4,Phase 2,Phase 1 83150-76-9 383414 6400441
28
Coal tar Approved Phase 4,Phase 3 8007-45-2
29
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
30
Propranolol Approved, Investigational Phase 4 525-66-6 4946
31
Topiramate Approved Phase 4,Phase 2 97240-79-4 5284627
32
Desflurane Approved Phase 4 57041-67-5 42113
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
34
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
35
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
36
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
37
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
38
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
39
Naloxegol Approved Phase 4,Phase 3,Phase 2,Phase 1 854601-70-0
40
Diltiazem Approved Phase 4,Phase 3,Phase 1 42399-41-7 39186
41
Mirabegron Approved Phase 4,Phase 3 223673-61-8
42
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
43
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
44
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
45
Alvimopan Approved Phase 4,Phase 3,Phase 2 156053-89-3 5488548
46
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
47
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
48
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
49
Orphenadrine Approved Phase 4 83-98-7 4601
50
Tramadol Approved, Investigational Phase 4 27203-92-5 33741

Interventional clinical trials:

(show top 50) (show all 923)
id Name Status NCT ID Phase
1 Study Evaluating The Safety Of Subcutaneous Methylnaltrexone In Treatment Of Opioid-Induced Constipation Unknown status NCT00672139 Phase 4
2 Lactobacillus Reuteri in Children With Constipation Unknown status NCT01388712 Phase 4
3 Polyethylene Glycol for Childhood Constipation Unknown status NCT01875744 Phase 4
4 Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit Unknown status NCT00844831 Phase 4
5 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4
6 A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy Unknown status NCT01109511 Phase 4
7 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4
8 A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely Unknown status NCT00889655 Phase 4
9 The Use of Botox in Advanced Parkinson's Patients Experiencing Pain Unknown status NCT02472210 Phase 4
10 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4
11 Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele Unknown status NCT00175123 Phase 4
12 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4
13 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
14 A Non-interventional, Observational Study for Quality of Life (Overall Health Assessment) in Patients With Chronic Severe Pain During Targinact® Treatment Unknown status NCT01710917 Phase 4
15 Transversus Abdominis Plane Blocks With Abdominoplasty Unknown status NCT01278264 Phase 4
16 A Study to Assess Different Diagnostic Criteria of Chronic Constipation in Asia Completed NCT01880294 Phase 4
17 An Observational Study to Evaluate the Quality of Life in Korean Female Participants With Chronic Constipation Completed NCT01902537 Phase 4
18 Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation Completed NCT02147574 Phase 4
19 Comparison of Lubiprostone and Placebo for the Relief of Constipation From Constipating Medications Completed NCT01096290 Phase 4
20 Lubiprostone in Patients With Multiple Sclerosis Associated Constipation Completed NCT01236534 Phase 4
21 The Effect of Probiotics on Constipation, and Intestinal Microflora in Children With Functional Constipation Completed NCT03054805 Phase 4
22 Methylnaltrexone Use for Opioid-induced Postoperative Constipation Completed NCT01773096 Phase 4
23 Polyethyleneglycol3350 vs Tegaserod in Treatment of Patients With Chronic Constipation Completed NCT00153140 Phase 4
24 Soy Polysaccharide Fiber for the Treatment of Chronic Constipation in Children: a Randomized, Double-blind Trial Completed NCT01267370 Phase 4
25 Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced Illness Completed NCT00672477 Phase 4
26 Evaluation of Long-term Prucalopride Treatment With Chronic Constipation in Subjects Aged ≥ 18 Years Completed NCT01424228 Phase 4
27 Efficacy and Safety of Prucalopride in Combination With Polyethylene Glycol or Lactulose in Women With Chronic Constipation Completed NCT02228616 Phase 4
28 Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children Completed NCT01592734 Phase 4
29 Preference of Tegaserod vs. PEG 3350 in Patients With Constipation Completed NCT00171522 Phase 4
30 Comparison of PEG Solutions With and Without Electrolytes in the Treatment of Constipation Completed NCT00603681 Phase 4
31 Lactobacillus Reuteri DSM 17938 in Functional Constipation Completed NCT01244945 Phase 4
32 Efficacy, Safety and Tolerability of Tegaserod in Patients With Chronic Constipation Completed NCT00149877 Phase 4
33 Safety and Efficacy of Lubiprostone in Pediatric Patients With Constipation Completed NCT00452335 Phase 4
34 Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications Completed NCT00153127 Phase 4
35 Dietary Fiber Mixture in Constipated Pediatric Patients Completed NCT01333787 Phase 4
36 A Pilot Study of a New MiraLax® Dose Formulation For Use in Constipated Children Completed NCT00319670 Phase 4
37 Lcr35 for Children With Functional Constipation Completed NCT01985867 Phase 4
38 Extended Use of Polyethyleneglycol3350 Laxative in Constipated Patients Completed NCT00153153 Phase 4
39 Study Comparing PEG 3350 Laxative to Placebo in the Treatment of Occasional Constipation (Study CL2007-12)(P08216) Completed NCT00770432 Phase 4
40 The Effectiveness of Lubiprostone in Constipated Diabetics Completed NCT01170039 Phase 4
41 An Open Label Study of Chronic Polyethyleneglycol3350 Use in Constipated Patients Completed NCT00164125 Phase 4
42 A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC). Completed NCT01957046 Phase 4
43 Effects of Lubiprostone on Gastric Function in Patients With Chronic Idiopathic Constipation Completed NCT01460225 Phase 4
44 Investigation of Dried Plums in the Treatment of Adults With Constipation Completed NCT01180725 Phase 4
45 PolyethyleneGlycol3350 Laxative vs Placebo in Constipated Children Completed NCT00153114 Phase 4
46 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4
47 A Study to Compare the Effect of Transipeg 2.95 g or Forlax Junior 4 g in Children With Constipation Completed NCT01810653 Phase 4
48 Amitiza in Constipation Associated With PD (Parkinson's Disease) Completed NCT00908076 Phase 4
49 Study of Long-Term Use of Forlax® in Elderly Patients With Chronic Constipation Completed NCT00276354 Phase 4
50 Sacral Nerve Stimulation for Anal Incontinence and Bowel Control Completed NCT00200005 Phase 4

Search NIH Clinical Center for Constipation

Cochrane evidence based reviews: constipation

Genetic Tests for Constipation

Genetic tests related to Constipation:

id Genetic test Affiliating Genes
1 Constipation 29

Anatomical Context for Constipation

MalaCards organs/tissues related to Constipation:

39
Colon, Kidney, Testes, Small Intestine, Ovary, Prostate, Brain

Publications for Constipation

Articles related to Constipation:

(show top 50) (show all 842)
id Title Authors Year
1
Depression but Not Symptom Severity is Associated With Work and School Absenteeism in Refractory Chronic Constipation. ( 28059936 )
2017
2
Quantifying traditional Chinese medicine patterns using modern test theory: an example of functional constipation. ( 28086767 )
2017
3
Chronic constipation diagnosis and treatment evaluation: the "CHRO.CO.DI.T.E." study. ( 28088179 )
2017
4
Optimizing the Use of Linaclotide in Patients with Constipation-Predominant Irritable Bowel Syndrome: An Expert Consensus Report. ( 28083815 )
2017
5
Dietary intake, physical activity, and time management are associated with constipation in preschool children in Japan. ( 28049271 )
2017
6
Contemporary short- and long-term outcomes in patients with unremitting constipation and fecal incontinence treated with an antegrade continence enema. ( 27817835 )
2017
7
Is-it possible to distinguish irritable bowel syndrome with constipation from functional constipation? ( 28066860 )
2017
8
Reliability and validity of the Bowel Function Index for evaluating opioid-induced constipation: translation, cultural adaptation and validation of the Portuguese version (BFI-P). ( 27981871 )
2017
9
Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt-Hopkins Syndrome. ( 28251008 )
2017
10
Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats. ( 28066135 )
2017
11
Addressing Opioid-Associated Constipation Using Quality Oncology Practice Initiative Scores and Plan-Do-Study-Act Cycles. ( 28084881 )
2017
12
Effect Of Prucalopride on Intestinal Gas Tolerance in Patients With Functional Bowel Disorders and Constipation. ( 28090679 )
2017
13
An appraisal of clinical practice guidelines for constipation: a right attitude towards to guidelines. ( 27142422 )
2016
14
Dyspepsia and constipation in patients with schizophrenia spectrum disorders. ( 27564411 )
2016
15
Shared Risk Factors for Constipation, Fecal Incontinence, and Combined Symptoms in Older U.S. Adults. ( 27783401 )
2016
16
Characteristics of the Contrast Enema Do Not Predict an Effective Bowel Management Regimen for Patients with Constipation or Fecal Incontinence. ( 27688984 )
2016
17
The Prevalence and Symptoms Characteristic of Functional Constipation Using Rome III Diagnostic Criteria among Tertiary Education Students. ( 27997551 )
2016
18
Calretinin-Immunoreactive Hypoinnervation in Down Syndrome (DS): Report of an Infant with Very Short-Segment Hirschsprung Disease and Comparison to Biopsy Findings in 20 Normal Infants and 11 Infants with DS and Chronic Constipation. ( 26230373 )
2016
19
Phase II trial of subcutaneous methylnaltrexone in the treatment of severe opioid-induced constipation (OIC) in cancer patients: an exploratory study. ( 27628064 )
2016
20
CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. ( 27127798 )
2016
21
Resolution of constipation, anal stricture, and iron deficiency anemia after iron infusion: an analogy with Plummer Vinson syndrome. ( 27917348 )
2016
22
Childhood constipation as an emerging public health problem. ( 27570423 )
2016
23
Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation. ( 27602240 )
2016
24
High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments. ( 27603712 )
2016
25
Gallotannin-Enriched Extract Isolated from Galla Rhois May Be a Functional Candidate with Laxative Effects for Treatment of Loperamide-Induced Constipation of SD Rats. ( 27618438 )
2016
26
Missed opportunity to deprescribe: docusate for constipation in medical inpatients. ( 27154771 )
2016
27
Constipation in Children: A Practical Review. ( 27171809 )
2016
28
Effectiveness of Pelvic Physiotherapy in Children With Functional Constipation, Compared with Standard Medical Care. ( 27650174 )
2016
29
Distinct resting-state brain activity in patients with functional constipation. ( 27569716 )
2016
30
Local and Oral Antibiotics with Avoidance of Constipation (LOABAC) Treatment for Anal Fissure: a New Concept in Conservative Management. ( 27186052 )
2016
31
Some Risk Factors of Chronic Functional Constipation Identified in a Pediatric Population Sample from Romania. ( 27994619 )
2016
32
Management of chronic constipation in patients with diabetes mellitus. ( 27987136 )
2016
33
Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willd extract. ( 27602249 )
2016
34
Assessing the Presence and Severity of Constipation with Plain Radiographs in Constipated Palliative Care Patients. ( 27203628 )
2016
35
Polyethylene glycol 3350 in occasional constipation: A one-week, randomized, placebo-controlled, double-blind trial. ( 27158544 )
2016
36
Case 1: Constipation, Irritability, and Poor Feeding in 2-month-old Boy. ( 27587641 )
2016
37
Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline. ( 28034973 )
2016
38
Chronic Functional Constipation and Encopresis in Children in Relationship with the Psychosocial Environment. ( 27990158 )
2016
39
Systematic review with meta-analysis: effect of fibre supplementation on chronic idiopathic constipation in adults. ( 27170558 )
2016
40
Acupuncture for Chronic Severe Functional Constipation: A Randomized, Controlled Trial. ( 27618593 )
2016
41
Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation. ( 27214096 )
2016
42
Psychological characteristics and GoNogo research of patients with functional constipation. ( 28033259 )
2016
43
On the prevalence of constipation and fecal incontinence, and their co-occurrence, in the Netherlands. ( 27913883 )
2016
44
Gender, Age, and Prevalence of Pediatric Irritable Bowel Syndrome and Constipation in Colombia: A Population-Based Study. ( 27579696 )
2016
45
Urinary Retention due to Constipation. ( 27580563 )
2016
46
Lubiprostone Accelerates Intestinal Transit and Alleviates Small Intestinal Bacterial Overgrowth in Patients With Chronic Constipation. ( 27650225 )
2016
47
Approach to Constipation in Children. ( 27156546 )
2016
48
Severe constipation in a patient with Myhre syndrome: a case report. ( 26636501 )
2016
49
Identifying Underlying Emotional Instability and Utilizing a Combined Intervention in the Treatment of Childhood Constipation and Encopresis-A Case Report. ( 27163279 )
2016
50
Dexloxiglumide for the treatment of constipation predominant irritable bowel syndrome. ( 27590736 )
2016

Variations for Constipation

ClinVar genetic disease variations for Constipation:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic/Likely pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416

Expression for Constipation

Search GEO for disease gene expression data for Constipation.

GO Terms for Constipation

Cellular components related to Constipation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.87 EDNRB HTR4 MLNR OPRM1 RET SLC6A4
2 extracellular region GO:0005576 9.85 CCK FLNA GAST GDNF MLN NTS
3 membrane raft GO:0045121 9.56 EDNRB OPRM1 RET SLC6A4
4 axon GO:0030424 9.35 CCK HTR3A OPRM1 RET TAC1
5 neuronal cell body GO:0043025 9.1 CCK FLNA HTR3A RET SST TAC1
6 plasma membrane GO:0005886 10.15 CLCN2 EDNRB FLNA HTR3A HTR4 KIT

Biological processes related to Constipation according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.95 MLN PYY SST TAC1
2 chemical synaptic transmission GO:0007268 9.83 HTR4 OPRM1 SST TAC1 TACR1
3 neuropeptide signaling pathway GO:0007218 9.81 OPRM1 PYY TAC1
4 regulation of blood pressure GO:0008217 9.78 EDNRB TAC1 TACR1
5 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.77 EDNRB OPRM1 TACR1
6 digestion GO:0007586 9.77 MLNR PYY SST
7 response to morphine GO:0043278 9.69 OPRM1 TAC1 TACR1
8 neural crest cell migration GO:0001755 9.67 EDNRB GDNF RET
9 melanocyte differentiation GO:0030318 9.65 EDNRB KIT
10 mRNA stabilization GO:0048255 9.65 GDNF VIP
11 regulation of sensory perception of pain GO:0051930 9.65 CCK EDNRB OPRM1
12 G-protein coupled receptor signaling pathway GO:0007186 9.65 EDNRB GAST HTR4 MLN MLNR OPRM1
13 vasoconstriction GO:0042310 9.64 EDNRB SLC6A4
14 positive regulation of ossification GO:0045778 9.63 TAC1 TACR1
15 developmental pigmentation GO:0048066 9.63 EDNRB KIT
16 positive regulation of synaptic transmission, GABAergic GO:0032230 9.62 TAC1 TACR1
17 sensory perception of pain GO:0019233 9.62 EDNRB OPRM1 TAC1 TACR1
18 regulation of appetite GO:0032098 9.61 HTR4 PYY
19 positive regulation of lymphocyte proliferation GO:0050671 9.58 TAC1 TACR1
20 tachykinin receptor signaling pathway GO:0007217 9.58 TAC1 TACR1
21 positive regulation of renal sodium excretion GO:0035815 9.58 EDNRB TAC1 TACR1
22 sperm ejaculation GO:0042713 9.57 SLC6A4 TACR1
23 positive regulation of action potential GO:0045760 9.56 TAC1 TACR1
24 positive regulation of synaptic transmission, cholinergic GO:0032224 9.55 TAC1 TACR1
25 positive regulation of saliva secretion GO:0046878 9.54 TAC1 TACR1
26 detection of abiotic stimulus GO:0009582 9.52 TAC1 TACR1
27 posterior midgut development GO:0007497 9.46 EDNRB RET
28 eating behavior GO:0042755 9.46 CCK OPRM1 PYY TACR1
29 enteric nervous system development GO:0048484 9.43 EDNRB GDNF RET
30 response to pain GO:0048265 8.92 EDNRB RET TAC1 TACR1
31 signal transduction GO:0007165 10.11 CCK EDNRB GAST GDNF HTR4 KIT
32 positive regulation of cell proliferation GO:0008284 10.02 CCK EDNRB GDNF KIT VIP

Molecular functions related to Constipation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.55 EDNRB FLNA HTR4 OPRM1 TACR1
2 neuropeptide hormone activity GO:0005184 9.26 CCK NTS PYY VIP
3 hormone activity GO:0005179 9.1 CCK GAST MLN PYY SST VIP

Sources for Constipation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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