MCID: CNS004
MIFTS: 45

Constipation malady

Gastrointestinal diseases category

Aliases & Classifications for Constipation

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Constipation, Aliases & Descriptions:

Name: Constipation 9 11 32


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:2089
ICD9CM27 564.0, 564.00
NCIt38 C37930
MeSH33 D003248
ICD1025 K59.0

Summaries for Constipation

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MedlinePlus:32 Constipation means that a person has three or fewer bowel movements in a week. the stool can be hard and dry. sometimes it is painful to pass. at one time or another, almost everyone gets constipated. in most cases, it lasts a short time and is not serious. there are many things you can do to prevent constipation. they include eating more fruits, vegetables and grains, which are high in fiber drinking plenty of water and other liquids getting enough exercise taking time to have a bowel movement when you need to using laxatives only if your doctor says you should asking your doctor if medicines you take may cause constipation it's not important that you have a bowel movement every day. if your bowel habits change, however, check with your doctor. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Constipation is related to hirschsprung disease 1 and morbid obesity. An important gene associated with Constipation is CLCN2 (chloride channel, voltage-sensitive 2), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Peptide ligand-binding receptors. The compounds thiorphan and captopril have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and testes, and related mouse phenotypes are vision/eye and normal.

Wikipedia:63 Constipation (also known as costiveness or dyschezia) refers to bowel movements that are infrequent or... more...

Related Diseases for Constipation

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Diseases related to Constipation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 291)
idRelated DiseaseScoreTop Affiliating Genes
1hirschsprung disease 130.4VIP, NRTN
2morbid obesity30.2PYY
3diarrhea30.2VIP, PYY
4cystic fibrosis30.0CLCN2, AQP3, VIP
5diabetes insipidus, nephrogenic29.8AQP7, AQP3
6obesity29.5PYY, AQP7, ADRA2A
7irritable bowel syndrome10.7
8fecal incontinence10.6
9blindness10.5
10megacolon10.4
11rectal prolapse10.3
12hypotonia10.2
13urofacial syndrome 110.2
14outlet dysfunction constipation10.2
15coarse face hypotonia constipation10.2
16gilles de la tourette syndrome10.1TDO2, ADRA2A
17colorectal cancer10.1
18williams-beuren syndrome10.1
19coproporphyria10.1
20proctitis10.1
21infant botulism10.1
22intestinal pseudo-obstruction10.1
23porphyria10.1
24neurologic diseases10.1
25ileus10.1
26gastrointestinal stromal tumor10.1
27mowat-wilson syndrome10.1
28paroxysmal extreme pain disorder10.1
29porphyria, acute intermittent10.1
30liddle syndrome10.1
31malonyl-coa decarboxylase deficiency10.1
32smith-magenis syndrome10.1
33pitt-hopkins syndrome10.1
34rett syndrome10.1
35cerebral creatine deficiency syndrome 110.1
36celiac disease10.1
37rubinstein-taybi syndrome10.1
38caudal regression syndrome10.1
39hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1
40propionicacidemia10.1
41neuronitis10.1
42gastroparesis10.1
43cerebritis10.1
44colonic pseudo-obstruction10.1
45botulism10.1
46hemorrhoid10.1
47intestinal obstruction10.1
48neuropathy10.1
49prostatitis10.1
50generalized dominant dystrophic epidermolysis bullosa10.1

Graphical network of the top 20 diseases related to Constipation:



Diseases related to constipation

Symptoms for Constipation

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Drugs & Therapeutics for Constipation

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Drug clinical trials:

Search ClinicalTrials for Constipation

Search NIH Clinical Center for Constipation

Genetic Tests for Constipation

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Anatomical Context for Constipation

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MalaCards organs/tissues related to Constipation:

31
Colon, Kidney, Testes, Ovary, Small intestine, Prostate, Spinal cord, Spleen, Brain, Heart, Smooth muscle

Animal Models for Constipation or affiliated genes

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MGI Mouse Phenotypes related to Constipation:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8CLCN2, AQP3, NRTN, TDO2
2MP:00028738.6TAC3, ADRA2A, VIP, PYY
3MP:00036318.3TDO2, NRTN, ADRA2A, CLCN2, PYY
4MP:00053798.2CLCN2, AQP7, VIP, NRTN
5MP:00053867.0TDO2, PYY, CLCN2, AQP3, VIP, ADRA2A
6MP:00053766.9PYY, CLCN2, AQP7, AQP3, VIP, ADRA2A

Publications for Constipation

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Articles related to Constipation:

(show top 50)    (show all 731)
idTitleAuthorsYear
1
Pseudo-Hirschsprung's disease with rectal hypoganglionosis: An autopsied case of circulatory failure due to severe constipation. (25497871)
2015
2
Laparoscopic-assisted subtotal colectomy combined with modified duhamel procedure for mixed constipation. (25848181)
2015
3
Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation. (25390617)
2014
4
Clinical and investigative assessment of constipation: A study from a referral center in western India. (25316170)
2014
5
Finger taps and constipation are closely related to symptoms of overactive bladder in male patients with Parkinson's disease. (23659545)
2014
6
Review article: linaclotide for the management of irritable bowel syndrome with constipation. (24433216)
2014
7
Management of faecal incontinence and constipation in adults with central neurological diseases. (24420006)
2014
8
Colonic electrical stimulation for the treatment of slow-transit constipation: a preliminary pilot study. (24048815)
2013
9
Interferential therapy: a new treatment for slow transit constipation. a pilot study in adults. (23046450)
2013
10
Clinical and psychosocial functioning in adolescents and young adults with anorectal malformations and chronic idiopathic constipation. (23553758)
2013
11
Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation. (24007408)
2013
12
Linaclotide-a novel secretagogue in the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (24001336)
2013
13
The use of prucalopride in real life for the treatment of constipation subtypes: ups and downs. (23703576)
2013
14
Association of constipation and fecal incontinence with attention-deficit/hyperactivity disorder. (24144702)
2013
15
Strumal carcinoid tumour of the ovary presenting with severe constipation. (23338927)
2013
16
In-hospital costs associated with chronic constipation in Belgium: a retrospective database study. (24325294)
2013
17
Chronic constipation. (23943571)
2013
18
The efficacy and safety study of electro-acupuncture for severe chronic functional constipation: study protocol for a multicenter, randomized, controlled trial. (23768191)
2013
19
Sacral nerve stimulation for constipation (Br J Surg 2013; 100: 174-181). (23239479)
2013
20
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
21
Impact of persistent constipation on health-related quality of life and mortality in older community-dwelling women. (23670115)
2013
22
Management of functional constipation in children with lower urinary tract symptoms: report from the Standardization Committee of the International Children's Continence Society. (23313210)
2013
23
Effect of dietary fiber on constipation: a meta analysis. (23326148)
2012
24
Celiac disease is overrepresented in patients with constipation. (22434186)
2012
25
Constipation and aspiration pneumonia. (22712814)
2012
26
Re: oral docusate in the management of constipation in hospice patients. (23217455)
2012
27
Transabdominal electrical stimulation increases colonic propagating pressure waves in paediatric slow transit constipation. (23217889)
2012
28
Chronic constipation due to delayed diagnosis of a congenital anal web. (22271242)
2012
29
Constipation is a major complication after posterior sagittal anorectoplasty for anorectal malformations in children. (22964283)
2012
30
Development and assessment of the constipation-related disability scale. (22248425)
2012
31
OTC polyethylene glycol 3350 and pharmacists' role in managing constipation. (22618979)
2012
32
Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation. (21585622)
2011
33
The pathophysiology of chronic constipation. (22114753)
2011
34
Chronic constipation may signify higher risk of heart disease. If you suffer from chronic constipation, see your cardiologist. (23019713)
2011
35
Managing functional constipation in children. (23204909)
2011
36
A topic in 10 questions: how to manage infant constipation. (22132562)
2011
37
Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. (20691689)
2010
38
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
39
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
40
Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation. (15688149)
2005
41
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. (16048580)
2005
42
Pathology of chronic constipation in pediatric and adult coloproctology. (15902901)
2005
43
May chronic childhood constipation cause oxidative stress and potential free radical damage to children? (15602823)
2004
44
The constipated child: how likely is Hirschsprung's disease? (12698267)
2003
45
Chronic constipation--a lethal danger in patients with systemic scleroderma. (11785605)
2001
46
Effects of erythromycin on human colonic circular muscle in idiopathic chronic constipation. (10620004)
2000
47
Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation. (10027360)
1999
48
Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. (9129468)
1997
49
Function of the striated anal sphincter during straining in control subjects and constipated patients with a radiologically normal rectum or idiopathic megacolon. (3198990)
1988
50
Letter: Constipation: a cause of urinary tract obstruction and infection. (1246799)
1976

Variations for Constipation

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Expression for genes affiliated with Constipation

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Search GEO for disease gene expression data for Constipation.

Pathways for genes affiliated with Constipation

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Pathways related to Constipation according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4ADRA2A, PYY
2
Show member pathways
9.1TAC3, ADRA2A, PYY
3
Show member pathways
9.0AQP7, AQP3
4
Show member pathways
8.7AQP3, AQP7, CLCN2

Compounds for genes affiliated with Constipation

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Compounds related to Constipation according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1thiorphan43 28 1212.0VIP, TAC3
2captopril43 59 49 28 1214.0VIP, TAC3
36-hydroxydopamine4310.0VIP, NRTN
4omeprazole43 49 28 24 1214.0CLCN2, PYY
5capsaicin43 2810.9VIP, TAC3
6hexamethonium43 2810.9VIP, PYY
7oxyntomodulin43 5910.8PYY, VIP
8bromocriptine43 28 1211.8VIP, ADRA2A
9yohimbine43 2 28 1212.8ADRA2A, PYY
10amiloride43 28 1211.8ADRA2A, VIP
11octreotide43 59 28 1212.7VIP, PYY
12clonidine43 49 28 1212.7ADRA2A, PYY
13phenylephrine43 28 24 1212.7ADRA2A, VIP
14propranolol43 28 49 24 1213.6VIP, PYY
15melatonin43 28 59 24 1213.6TDO2, VIP
16ornithine43 2410.5TDO2, PYY
17atropine43 28 1211.5TAC3, VIP, PYY
18choline43 24 1211.5VIP, ADRA2A, NRTN
19tetrodotoxin43 59 2811.5PYY, VIP, TAC3
20carbachol43 28 1211.5PYY, VIP, TAC3
215-hydroxytryptamine439.5TDO2, VIP, PYY
22chloride439.4VIP, AQP3, CLCN2
23hg2+289.4AQP3, AQP7
24haloperidol43 49 28 2 1213.4PYY, VIP
25phentolamine43 28 1211.4ADRA2A, VIP, PYY
26isoproterenol43 1210.3ADRA2A, VIP, PYY
27norepinephrine43 24 1211.3PYY, VIP, ADRA2A
28aspartate439.3VIP, ADRA2A, TDO2
29catecholamine439.2ADRA2A, VIP
30acetylcholine43 49 28 24 1213.2PYY, VIP, NRTN, TAC3
31cyclic amp43 2410.0ADRA2A, VIP, PYY
32gnrh439.0TAC3, ADRA2A, VIP, PYY
33adenylate439.0AQP3, VIP, ADRA2A
34estrogen438.9TAC3, ADRA2A, VIP, PYY
35forskolin43 49 1210.9VIP, AQP3, AQP7
36dopamine43 28 24 1211.7PYY, VIP, ADRA2A, NRTN, TAC3
37tyrosine438.2PYY, VIP, ADRA2A, NRTN, TAC3, TDO2

GO Terms for genes affiliated with Constipation

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Cellular components related to Constipation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00059119.0AQP3, AQP7
2extracellular regionGO:00055768.5TAC3, NRTN, VIP, PYY

Biological processes related to Constipation according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:00459099.6ADRA2A, VIP
2female pregnancyGO:00075659.5TAC3, ADRA2A
3cellular component movementGO:00069289.4ADRA2A, PYY
4renal water absorptionGO:00702959.2AQP3, AQP7
5water transportGO:00068339.1AQP3, AQP7
6G-protein coupled receptor signaling pathwayGO:00071869.1PYY, VIP, ADRA2A
7excretionGO:00075889.0AQP7, AQP3
8transmembrane transportGO:00550858.4AQP3, AQP7, CLCN2

Molecular functions related to Constipation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.5VIP, PYY
2neuropeptide hormone activityGO:00051849.2VIP, PYY
3water channel activityGO:00152508.9AQP3, AQP7

Products for genes affiliated with Constipation

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Sources for Constipation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet