MCID: CNS004
MIFTS: 57

Constipation

Categories: Gastrointestinal diseases

Aliases & Classifications for Constipation

MalaCards integrated aliases for Constipation:

Name: Constipation 12 28 40 41 14

Classifications:



Summaries for Constipation

MedlinePlus : 40 Constipation means that a person has three or fewer bowel movements in a week. The stool can be hard and dry. Sometimes it is painful to pass. At one time or another, almost everyone gets constipated. In most cases, it lasts a short time and is not serious. There are many things you can do to prevent constipation. They include Eating more fruits, vegetables and grains, which are high in fiber Drinking plenty of water and other liquids Getting enough exercise Taking time to have a bowel movement when you need to Using laxatives only if your doctor says you should Asking your doctor if medicines you take may cause constipation It's not important that you have a bowel movement every day. If your bowel habits change, however, check with your doctor. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Constipation is related to intestinal pseudo-obstruction and hypoganglionosis. An important gene associated with Constipation is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Dexamethasone and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and testes, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces.

Wikipedia : 72 Constipation refers to bowel movements that are infrequent or hard to pass. The stool is often hard and... more...

Related Diseases for Constipation

Diseases related to Constipation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 intestinal pseudo-obstruction 32.2 EDNRB FLNA RET
2 hypoganglionosis 32.2 GDNF RET
3 intestinal obstruction 31.9 EDNRB FLNA GDNF RET
4 multiple endocrine neoplasia, type iib 31.6 EDNRB GDNF RET
5 central hypoventilation syndrome, congenital 31.5 EDNRB GDNF RET
6 hirschsprung disease 1 31.4 EDNRB GDNF KIT RET TAC1 VIP
7 irritable bowel syndrome 30.9 CCK HTR3A HTR4 MLN SLC6A4 TAC1
8 colonic pseudo-obstruction 30.7 HTR4 KIT MLN MLNR SST
9 megacolon 30.6 EDNRB GDNF RET VIP
10 anismus 30.1 TAC1 VIP
11 functional diarrhea 29.6 HTR3A HTR4 TAC1
12 neurofibromatosis, type iv, of riccardi 29.6 KIT RET SST
13 diarrhea 29.5 CCK GAST HTR3A SST
14 dyspepsia 29.3 CCK HTR3A SLC6A4 SST
15 gastroparesis 28.5 CCK GAST HTR3A MLN MLNR
16 outlet dysfunction constipation 12.1
17 coarse face hypotonia constipation 11.9
18 fecal incontinence 11.2
19 opitz-kaveggia syndrome 11.2
20 parkinson disease, late-onset 11.1
21 sacral defect with anterior meningocele 11.1
22 porphyria 11.1
23 colorectal cancer 11.0
24 porphyria, acute hepatic 11.0
25 primary hyperparathyroidism 11.0
26 hemorrhoid 11.0
27 celiac disease 1 11.0
28 adrenomyodystrophy 11.0
29 pitt-hopkins syndrome 11.0
30 bartter disease 11.0
31 beriberi 11.0
32 peritonitis 11.0
33 disseminated peritoneal leiomyomatosis 11.0
34 ulcerative proctitis 11.0
35 hashimoto thyroiditis 10.8
36 urofacial syndrome 1 10.8
37 fg syndrome 2 10.8
38 fg syndrome 4 10.8
39 neuropathy, hereditary sensory and autonomic, type vii 10.8
40 tarlov cysts 10.8
41 adiposis dolorosa 10.6
42 hyperparathyroidism 2 with jaw tumors 10.6
43 visceral myopathy 10.6
44 paroxysmal extreme pain disorder 10.6
45 juvenile polyposis syndrome 10.6
46 hypothyroidism, congenital, nongoitrous, 2 10.6
47 malonyl-coa decarboxylase deficiency 10.6
48 hirschsprung disease 2 10.6
49 curry-jones syndrome 10.6
50 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 4 10.6

Graphical network of the top 20 diseases related to Constipation:



Diseases related to Constipation

Symptoms & Phenotypes for Constipation

GenomeRNAi Phenotypes related to Constipation according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 HTR3A MLN SLC6A4
2 Decreased viability GR00381-A-3 9.1 HTR3A MLN SLC6A4

MGI Mouse Phenotypes related to Constipation:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.42 SLC6A4 NALCN OPRM1 SST PYY TAC1
2 homeostasis/metabolism MP:0005376 10.31 SLC6A4 NALCN OPRM1 SST PYY RET
3 cardiovascular system MP:0005385 10.18 RET KIT SLC6A4 TAC1 FLNA CLCN2
4 endocrine/exocrine gland MP:0005379 10.17 SLC6A4 OPRM1 RET KIT CCK GAST
5 immune system MP:0005387 10.15 RET KIT OPRM1 SST FLNA GAST
6 mortality/aging MP:0010768 10.13 RET KIT NALCN SLC6A4 OPRM1 SST
7 nervous system MP:0003631 10.13 SLC6A4 NALCN OPRM1 SST PYY RET
8 digestive/alimentary MP:0005381 10.11 RET KIT OPRM1 SST GAST CLCN2
9 normal MP:0002873 9.81 RET KIT SLC6A4 OPRM1 SST TAC1
10 renal/urinary system MP:0005367 9.5 RET KIT TAC1 CCK GDNF EDNRB
11 respiratory system MP:0005388 9.17 RET KIT NALCN FLNA EDNRB TACR1

Drugs & Therapeutics for Constipation

Drugs for Constipation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 563)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
2
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
3
Loperamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53179-11-6 3955
4
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
5
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
6
Diltiazem Approved, Investigational Phase 4,Phase 3,Phase 1 42399-41-7 39186
7
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
8
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2 465-65-6 5284596
9
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
10
Lactulose Approved Phase 4,Phase 3,Phase 2,Phase 1 4618-18-2 11333
11
Amitriptyline Approved Phase 4 50-48-6 2160
12
Lubiprostone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 136790-76-6 656719
13
Oxybutynin Approved, Investigational Phase 4,Phase 3 5633-20-5 4634
14
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 16590-41-3 5360515
15
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 76-42-6 5284603
16
Ropivacaine Approved Phase 4,Phase 3,Phase 2 84057-95-4 175805 71273
17
Methylnaltrexone Approved Phase 4,Phase 2,Phase 3 916055-93-1, 83387-25-1 6603824
18
Cyclobenzaprine Approved Phase 4 303-53-7 2895
19
Bisacodyl Approved Phase 4,Phase 3,Phase 2 603-50-9
20
Curcumin Approved, Investigational Phase 4 458-37-7 969516
21
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
22
Celecoxib Approved, Investigational Phase 4,Phase 1 169590-42-5 2662
23
Ibuprofen Approved Phase 4,Phase 1 15687-27-1 3672
24
Octreotide Approved, Investigational Phase 4,Phase 2,Phase 1 83150-76-9 6400441 383414
25
Propranolol Approved, Investigational Phase 4 525-66-6 4946
26
Topiramate Approved Phase 4,Phase 2 97240-79-4 5284627
27
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
28
Ondansetron Approved Phase 4 99614-02-5 4595
29
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 38396-39-3, 2180-92-9 2474
30
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
31
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
32
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
33
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
34
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
35
Hydromorphone Approved, Illicit Phase 4,Phase 2,Phase 3 466-99-9 5284570
36
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
37
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3 13422-51-0 5460373 44475014 11953898
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
39
Alvimopan Approved, Investigational Phase 4,Phase 3,Phase 2 156053-89-3 5488548
40
Bismuth Subsalicylate Approved, Vet_approved Phase 4,Phase 3,Phase 2 14882-18-9 53629521
41
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
42
Desflurane Approved Phase 4 57041-67-5 42113
43
Magnesium oxide Approved Phase 4,Phase 2 1309-48-4 14792
44
Sorbitol Approved Phase 4,Phase 3 50-70-4 5780
45 Mirabegron Approved Phase 4,Phase 3 223673-61-8
46
Naloxegol Approved Phase 4,Phase 3,Phase 2,Phase 1 854601-70-0
47
Magnesium Hydroxide Approved, Investigational Phase 4,Phase 2 1309-42-8
48
Coal tar Approved Phase 4,Phase 3 8007-45-2
49 Magnesium citrate Approved Phase 4
50
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211

Interventional clinical trials:

(show top 50) (show all 987)

# Name Status NCT ID Phase Drugs
1 Lactobacillus Reuteri in Children With Constipation Unknown status NCT01388712 Phase 4
2 Study Evaluating The Safety Of Subcutaneous Methylnaltrexone In Treatment Of Opioid-Induced Constipation Unknown status NCT00672139 Phase 4 Methylnaltrexone bromide
3 Polyethylene Glycol for Childhood Constipation Unknown status NCT01875744 Phase 4 Polyethylene glycol 4000
4 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4 Mosapride
5 A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy Unknown status NCT01109511 Phase 4 naloxone;oxycodone
6 Pediatrics Anal Fissures Treatment With Polyethylene Glycol Unknown status NCT02419534 Phase 4 Polyethylene glycol;Polyethylene glycol with Diltiazem
7 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
8 A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely Unknown status NCT00889655 Phase 4 Golytely (polyethylene glycol);MiraLax (polyethylene glycol 3350)
9 The Use of Botox in Advanced Parkinson's Patients Experiencing Pain Unknown status NCT02472210 Phase 4 Botulinum Toxin
10 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
11 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
12 Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele Unknown status NCT00175123 Phase 4 Botulinum A toxin
13 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
14 A Non-interventional, Observational Study for Quality of Life (Overall Health Assessment) in Patients With Chronic Severe Pain During Targinact® Treatment Unknown status NCT01710917 Phase 4 Targinact® (oxycodon/naloxon)
15 Transversus Abdominis Plane Blocks With Abdominoplasty Unknown status NCT01278264 Phase 4 Ropivacaine 0.25%, 0.5 ml/kg;Ropivacaine 0.25%, 0.5 ml/kg
16 A Study to Assess Different Diagnostic Criteria of Chronic Constipation in Asia Completed NCT01880294 Phase 4 No intervention
17 An Observational Study to Evaluate the Quality of Life in Korean Female Participants With Chronic Constipation Completed NCT01902537 Phase 4 Prucalopride; observational study
18 Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation Completed NCT02147574 Phase 4
19 The Effect of Probiotics on Constipation, and Intestinal Microflora in Children With Functional Constipation Completed NCT03054805 Phase 4 Magnesium Oxide;MIYAIRI-BM
20 Comparison of Lubiprostone and Placebo for the Relief of Constipation From Constipating Medications Completed NCT01096290 Phase 4 lubiprostone;Matched placebo
21 Lubiprostone in Patients With Multiple Sclerosis Associated Constipation Completed NCT01236534 Phase 4 Lubiprostone;Placebo
22 Methylnaltrexone Use for Opioid-induced Postoperative Constipation Completed NCT01773096 Phase 4 Methylnaltrexone;Senna, docusate sodium, bisacodyl, magnesium hydroxide, Miralax
23 Soy Polysaccharide Fiber for the Treatment of Chronic Constipation in Children: a Randomized, Double-blind Trial Completed NCT01267370 Phase 4
24 Efficacy and Safety of Prucalopride in Combination With Polyethylene Glycol or Lactulose in Women With Chronic Constipation Completed NCT02228616 Phase 4 Prucalopride;Polyethylene glycol (PEG);Lactulose
25 Evaluation of Long-term Prucalopride Treatment With Chronic Constipation in Subjects Aged ≥ 18 Years Completed NCT01424228 Phase 4 placebo;prucalopride
26 Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children Completed NCT01592734 Phase 4 Polyethylene glycol with electrolytes
27 Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced Illness Completed NCT00672477 Phase 4 Methylnaltrexone bromide;Placebo
28 The Efficacy of Mutaflor(E. Coli Nissle 1917, Mutaflor®) for Chronic Constipation:Multicenter Study Completed NCT02726295 Phase 4 E. coli Nissle 1917(Mutaflor®);Placebo
29 To Evaluate Patient Preference of Movantik and Polyethylene Glycol 3350 for Opioid Induced Constipation Completed NCT03060512 Phase 4 Polyethylene Glycol 3350;Movantik
30 Polyethyleneglycol3350 vs Tegaserod in Treatment of Patients With Chronic Constipation Completed NCT00153140 Phase 4 polyethyleneglycol3350
31 Lactobacillus Reuteri DSM 17938 in Functional Constipation Completed NCT01244945 Phase 4
32 Comparison of PEG Solutions With and Without Electrolytes in the Treatment of Constipation Completed NCT00603681 Phase 4 Polyethylene glycol 4000;Polyethylene glycol 4000 with electrolytes
33 Lcr35 for Children With Functional Constipation Completed NCT01985867 Phase 4
34 Preference of Tegaserod vs. PEG 3350 in Patients With Constipation Completed NCT00171522 Phase 4 Tegaserod and Polyethylene Glycol 3350
35 Dietary Fiber Mixture in Constipated Pediatric Patients Completed NCT01333787 Phase 4
36 Efficacy, Safety and Tolerability of Tegaserod in Patients With Chronic Constipation Completed NCT00149877 Phase 4 Tegaserod
37 Safety and Efficacy of Lubiprostone in Pediatric Patients With Constipation Completed NCT00452335 Phase 4 Lubiprostone;Lubiprostone;Lubiprostone
38 A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC). Completed NCT01957046 Phase 4 Laxative
39 The Effectiveness of Lubiprostone in Constipated Diabetics Completed NCT01170039 Phase 4 Lubiprostone;Placebo
40 Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications Completed NCT00153127 Phase 4 polyethyleneglycol3350
41 Study Comparing PEG 3350 Laxative to Placebo in the Treatment of Occasional Constipation (Study CL2007-12)(P08216) Completed NCT00770432 Phase 4 Polyethylene glycol 3350
42 A Pilot Study of a New MiraLax® Dose Formulation For Use in Constipated Children Completed NCT00319670 Phase 4 MiraLax
43 Effects of Lubiprostone on Gastric Function in Patients With Chronic Idiopathic Constipation Completed NCT01460225 Phase 4 lubiprostone
44 Extended Use of Polyethyleneglycol3350 Laxative in Constipated Patients Completed NCT00153153 Phase 4 polyethyleneglycol3350
45 An Open Label Study of Chronic Polyethyleneglycol3350 Use in Constipated Patients Completed NCT00164125 Phase 4 polyethyleneglycol3350
46 A Study to Compare the Effect of Transipeg 2.95 g or Forlax Junior 4 g in Children With Constipation Completed NCT01810653 Phase 4 Macrogol (Transipeg, BAY81-8430);Macrogol (Forlax)
47 Investigation of Dried Plums in the Treatment of Adults With Constipation Completed NCT01180725 Phase 4
48 Amitiza in Constipation Associated With PD (Parkinson's Disease) Completed NCT00908076 Phase 4 LUBIPROSTONE
49 PolyethyleneGlycol3350 Laxative vs Placebo in Constipated Children Completed NCT00153114 Phase 4 polyethyleneglycol3350
50 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4

Search NIH Clinical Center for Constipation

Cochrane evidence based reviews: constipation

Genetic Tests for Constipation

Genetic tests related to Constipation:

# Genetic test Affiliating Genes
1 Constipation 28

Anatomical Context for Constipation

MalaCards organs/tissues related to Constipation:

38
Colon, Breast, Testes, Kidney, Spinal Cord, Lung, Liver

Publications for Constipation

Articles related to Constipation:

(show top 50) (show all 893)
# Title Authors Year
1
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. ( 29359574 )
2018
2
Abdominal radiograph usage trends in the setting of constipation: a 10-year experience. ( 29392367 )
2018
3
The Burden of Opioid-Induced Constipation in Younger Patients with Chronic Noncancer Pain. ( 29420795 )
2018
4
Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic non-cancer pain: a randomized, double-blind, placebo-controlled phase 3 study. ( 29419653 )
2018
5
Constipation in children: NICE guidance in practice in two emergency departments. ( 29395754 )
2018
6
Prolonged-release oxycodone/naloxone reduces opioid-induced constipation and improves quality of life in laxative-refractory patients: results of an observational study. ( 29416370 )
2018
7
Are Senna based laxatives safe when used as long term treatment for constipation in children? ( 29429768 )
2018
8
Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation. ( 29441452 )
2018
9
Assessment and management of constipation for patients receiving palliative care in specialist palliative care settings: A systematic review of the literature. ( 29431016 )
2018
10
Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: study protocol for a randomized controlled trial. ( 29402303 )
2018
11
Acupuncture for patients with chronic functional constipation: A randomized controlled trial. ( 29392784 )
2018
12
Effects of a probiotic (SLAB51a8c) on clinical and histologic variables and microbiota of cats with chronic constipation/megacolon: a pilot study. ( 29065705 )
2018
13
Spotlight on naldemedine in the treatment of opioid-induced constipation in adult patients with chronic noncancer pain: design, development, and place in therapy. ( 29391826 )
2018
14
Randomized Phase III and Extension Studies of Naldemedine in Patients With Opioid-Induced Constipation and Cancer. ( 29406801 )
2018
15
Effects of Noninvasive Skin Stimulation with Microcones on Constipation: A Double-Blinded Controlled Study. ( 29410718 )
2018
16
Paediatric<i>Clostridium difficile</i>pseudomembranous colitis: a complication of refractory constipation? ( 29444797 )
2018
17
Clinical practice guidelines from the French National Society of Coloproctology in treating chronic constipation. ( 29406436 )
2018
18
The authors respond: The ED diagnostic workup of constipation in children. ( 29395764 )
2018
19
Dietary intake, physical activity, and time management are associated with constipation in preschool children in Japan. ( 28049271 )
2017
20
Treatment With Naloxegol Versus Placebo: Pain Assessment in Patients With Noncancer Pain and Opioid-Induced Constipation. ( 28898536 )
2017
21
Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt-Hopkins Syndrome. ( 28251008 )
2017
22
Addressing Opioid-Associated Constipation Using Quality Oncology Practice Initiative Scores and Plan-Do-Study-Act Cycles. ( 28084881 )
2017
23
A retrospective audit on usage of Diatrizoate Meglumine (Gastrografin(Ar)) for intestinal obstruction or constipation in patients with advanced neoplasms. ( 28805119 )
2017
24
Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats. ( 28066135 )
2017
25
Physical activity may decrease the likelihood of children developing constipation. ( 28898506 )
2017
26
Supporting patients in reducing postoperative constipation: fundamental nursing care - a quasi-experimental study. ( 28881476 )
2017
27
Oral prolonged-release oxycodone/naloxone for managing pain and opioid-induced constipation: A review of the evidence. ( 28944983 )
2017
28
A case of sulfhemoglobinemia in a child with chronic constipation. ( 28348950 )
2017
29
Is-it possible to distinguish irritable bowel syndrome with constipation from functional constipation? ( 28066860 )
2017
30
Quantifying traditional Chinese medicine patterns using modern test theory: an example of functional constipation. ( 28086767 )
2017
31
Contemporary short- and long-term outcomes in patients with unremitting constipation and fecal incontinence treated with an antegrade continence enema. ( 27817835 )
2017
32
Enuresis and Constipation in a 12-Year-Old. ( 28952347 )
2017
33
Reliability and validity of the Bowel Function Index for evaluating opioid-induced constipation: translation, cultural adaptation and validation of the Portuguese version (BFI-P). ( 27981871 )
2017
34
Editorial: subgroups in irritable bowel syndrome-more than just diarrhoea and constipation? ( 28880445 )
2017
35
Aqueous Extracts of<i>Herba Cistanche</i>Promoted Intestinal Motility in Loperamide-Induced Constipation Rats by Ameliorating the Interstitial Cells of Cajal. ( 29445412 )
2017
36
Pelvic physiotherapy in addition to standard care is more effective than standard medical care alone for children with functional constipation [synopsis]. ( 28888690 )
2017
37
Bifidobacteria exert species-specific effects on constipation in BALB/c mice. ( 28884754 )
2017
38
Pelvic physiotherapy in addition to standard care is more effective than standard medical care alone for children with functional constipation [commentary]. ( 28935518 )
2017
39
More than constipation - bowel symptoms in Parkinson's disease and their connection to gut microbiota. ( 28891262 )
2017
40
The overlap of gastroesophageal reflux disease and functional constipation in children: the efficacy of constipation treatment. ( 28914696 )
2017
41
Constipation Is Related to Small Bowel Disturbance Rather Than Colonic Enlargement in Acquired Chagasic Megacolon. ( 28912906 )
2017
42
Botulinum toxin injection for childhood constipation is safe and can be effective regardless of anal sphincter dynamics. ( 29395154 )
2017
43
Optimizing the Use of Linaclotide in Patients with Constipation-Predominant Irritable Bowel Syndrome: An Expert Consensus Report. ( 28083815 )
2017
44
Endoscopic Mucosal Resection is Superior to Rectal Suction Biopsy for Analysis of Enteric Ganglia in Constipation and Dysmotility. ( 28893560 )
2017
45
Editorial: subgroups in irritable bowel syndrome-more than just diarrhoea and constipation? Authors' reply. ( 28880440 )
2017
46
Depression but Not Symptom Severity is Associated With Work and School Absenteeism in Refractory Chronic Constipation. ( 28059936 )
2017
47
Chronic constipation diagnosis and treatment evaluation: the "CHRO.CO.DI.T.E." study. ( 28088179 )
2017
48
Yangyin Runchang Decoction Improves Intestinal Motility in Mice with Atropine/Diphenoxylate-Induced Slow-Transit Constipation. ( 29403536 )
2017
49
Physiologic Management of Chronic Constipation: Let's FEED It. ( 28948409 )
2017
50
Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. ( 28799195 )
2017

Variations for Constipation

ClinVar genetic disease variations for Constipation:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic/Likely pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416

Expression for Constipation

Search GEO for disease gene expression data for Constipation.

GO Terms for Constipation

Cellular components related to Constipation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 CCK FLNA GAST GDNF MLN PYY
2 plasma membrane GO:0005886 9.97 CLCN2 EDNRB FLNA HTR3A HTR4 KIT
3 integral component of plasma membrane GO:0005887 9.91 EDNRB HTR4 MLNR OPRM1 RET SLC6A4
4 membrane raft GO:0045121 9.56 EDNRB OPRM1 RET SLC6A4
5 axon GO:0030424 9.35 CCK HTR3A OPRM1 RET TAC1
6 neuronal cell body GO:0043025 9.1 CCK FLNA HTR3A RET SST TAC1

Biological processes related to Constipation according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.96 MLN PYY SST TAC1
2 response to ethanol GO:0045471 9.84 HTR3A OPRM1 TACR1
3 neuropeptide signaling pathway GO:0007218 9.82 OPRM1 PYY TAC1
4 regulation of receptor activity GO:0010469 9.8 CCK GAST GDNF MLN PYY SST
5 regulation of blood pressure GO:0008217 9.79 EDNRB TAC1 TACR1
6 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.78 EDNRB OPRM1 TACR1
7 digestion GO:0007586 9.77 MLNR PYY SST
8 sensory perception of pain GO:0019233 9.71 EDNRB OPRM1 TAC1 TACR1
9 response to morphine GO:0043278 9.7 OPRM1 TAC1 TACR1
10 regulation of sensory perception of pain GO:0051930 9.69 CCK EDNRB OPRM1
11 neural crest cell migration GO:0001755 9.67 EDNRB GDNF RET
12 mRNA stabilization GO:0048255 9.66 GDNF VIP
13 melanocyte differentiation GO:0030318 9.65 EDNRB KIT
14 vasoconstriction GO:0042310 9.65 EDNRB SLC6A4
15 eating behavior GO:0042755 9.65 CCK OPRM1 TACR1
16 positive regulation of ossification GO:0045778 9.64 TAC1 TACR1
17 developmental pigmentation GO:0048066 9.63 EDNRB KIT
18 chemical synaptic transmission GO:0007268 9.63 HTR3A HTR4 OPRM1 SST TAC1 TACR1
19 positive regulation of synaptic transmission, GABAergic GO:0032230 9.62 TAC1 TACR1
20 regulation of appetite GO:0032098 9.62 HTR4 PYY
21 positive regulation of renal sodium excretion GO:0035815 9.61 EDNRB TAC1 TACR1
22 positive regulation of lymphocyte proliferation GO:0050671 9.59 TAC1 TACR1
23 tachykinin receptor signaling pathway GO:0007217 9.58 TAC1 TACR1
24 sperm ejaculation GO:0042713 9.58 SLC6A4 TACR1
25 positive regulation of action potential GO:0045760 9.57 TAC1 TACR1
26 detection of abiotic stimulus GO:0009582 9.56 TAC1 TACR1
27 positive regulation of saliva secretion GO:0046878 9.55 TAC1 TACR1
28 positive regulation of synaptic transmission, cholinergic GO:0032224 9.54 TAC1 TACR1
29 enteric nervous system development GO:0048484 9.5 EDNRB GDNF RET
30 posterior midgut development GO:0007497 9.46 EDNRB RET
31 G-protein coupled receptor signaling pathway GO:0007186 9.4 CCK EDNRB GAST HTR4 MLN MLNR
32 response to pain GO:0048265 9.26 EDNRB RET TAC1 TACR1
33 signal transduction GO:0007165 10.11 CCK EDNRB GAST GDNF HTR3A HTR4
34 positive regulation of cell proliferation GO:0008284 10.03 CCK EDNRB GDNF KIT VIP

Molecular functions related to Constipation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 GDNF KIT RET
2 neuropeptide hormone activity GO:0005184 9.13 CCK PYY VIP
3 hormone activity GO:0005179 9.1 CCK GAST MLN PYY SST VIP

Sources for Constipation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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