MCID: CNS004
MIFTS: 55

Constipation malady

Gastrointestinal diseases category

Summaries for Constipation

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Constipation means that a person has three or fewer bowel movements in a week. the stool can be hard and dry. sometimes it is painful to pass. at one time or another, almost everyone gets constipated. in most cases, it lasts a short time and is not serious. there are many things you can do to prevent constipation. they include eating more fruits, vegetables and grains, which are high in fiber drinking plenty of water and other liquids getting enough exercise taking time to have a bowel movement when you need to using laxatives only if your doctor says you should asking your doctor if medicines you take may cause constipation it's not important that you have a bowel movement every day. if your bowel habits change, however, check with your doctor. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Constipation is related to irritable bowel syndrome and hirschsprung's disease. An important gene associated with Constipation is CLCN2 (chloride channel, voltage-sensitive 2), and among its related pathways are Regulation of Water Balance by Renal Aquaporins and Passive Transport by Aquaporins. The compounds phentolamine and kassinin have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and testes, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:63 Constipation (also known as costiveness or dyschezia) refers to bowel movements that are infrequent or... more...

Aliases & Classifications for Constipation

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 27ICD9CM, 60UMLS, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

constipation 8 10 33


External Ids:

Disease Ontology8 DOID:2089
MeSH34 D003248
ICD9CM27 564.00, 564.0
NCIt39 C37930
ICD1025 K59.0

Related Diseases for Constipation

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Constipation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome31.0HTR4, MLN, TAC1
2hirschsprung's disease30.4TAC1, VIP, NRTN
3diarrhea30.2PYY, MLN, TAC1, VIP
4parkinson's disease30.0PDYN, NRTN, CYP2D7P1, TAC1
5gastroparesis30.0HTR4, MLNR, MLN
6obesity30.0ADRA2A, AQP7, MLN, PYY
7cystic fibrosis30.0AQP3, CLCN2, VIP
8neuropathy30.0TAC1
9dyspepsia29.6MLN, MLNR
10diabetes mellitus29.6TAC1, PYY, MLN
11schizophrenia29.6AQP4, TDO2, ADRA2A, TAC1, HTR4, PDYN
12inflammatory bowel disease29.6TAC1
13fecal incontinence10.5
14megacolon10.3
15rectal prolapse10.3
16intestinal obstruction10.2
17proctitis10.1
18infant botulism10.1
19celiac disease10.1
20outlet dysfunction constipation10.1
21intestinal pseudo-obstruction10.1
22spina bifida10.1
23colorectal cancer10.1
24neurologic diseases10.1
25coarse face hypotonia constipation10.1
26fg syndrome10.0
27primary hyperparathyroidism10.0
28cerebritis10.0
29neuronitis10.0
30colonic pseudo-obstruction10.0
31colonic disease10.0
32porphyria10.0
33prostatitis10.0
34hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.0
35ileus10.0MLNR, MLN
36gallbladder disease10.0PYY, MLN, MLNR
37functional colonic disease10.0HTR4, MLNR
38gastrointestinal system disease10.0MLN, PYY, HTR4
39cholera10.0PYY, TAC1, VIP, ADRA2A
40colon adenocarcinoma10.0VIP
41diabetic autonomic neuropathy10.0MLNR
42nephrogenic diabetes insipidus10.0AQP7, AQP4, AQP3
43pain agnosia10.0TAC1, PDYN, CYP2D7P1
44dumping syndrome10.0MLN, PYY
45pheochromocytoma10.0VIP, PYY, PDYN, MLN
46neuroendocrine tumor10.0VIP, PYY, TAC1
47adenocarcinoma10.0AQP4, AQP3, ADRA2A, TAC1, PYY, VIP
48ulcerative colitis10.0VIP, TAC1, TACR2, MLN
49duodenogastric reflux10.0MLN
50carcinoid syndrome10.0VIP, TAC1, PYY

Graphical network of the top 20 diseases related to Constipation:



Diseases related to constipation

Clinical Features for Constipation

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Drugs & Therapeutics for Constipation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Constipation

Drug clinical trials:

Search ClinicalTrials for Constipation

Search NIH Clinical Center for Constipation

Search CenterWatch for Constipation

Genetic Tests for Constipation

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Anatomical Context for Constipation

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Sources:
32MalaCards
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MalaCards organs/tissues related to Constipation:

32
Colon, Kidney, Testes, Ovary, Prostate, Small intestine, Spinal cord, Smooth muscle, Heart, Brain, Spleen

Animal Models for Constipation or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Constipation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.3PDYN, HTR4, ISL2, NRTN, CLCN2, ADRA2A
2MP:000538610.2AQP4, VIP, PYY, PDYN, HTR4, NRTN
3MP:000537610.0HTR4, PDYN, PYY, VIP, CLCN2, ADRA2A

Publications for Constipation

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Sources:
50PubMed
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Articles related to Constipation:

(show top 50)    (show all 689)
idTitleAuthorsYear
1
Colonic electrical stimulation for the treatment of slow-transit constipation: a preliminary pilot study. (24048815)
2013
2
Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation. (24007408)
2013
3
Chronic constipation. (23943571)
2013
4
The Self-Report Fecal Incontinence and Constipation Questionnaire in Patients With Pelvic-Floor Dysfunction Seeking Outpatient Rehabilitation. (24114438)
2013
5
The association between prucalopride efficacy and constipation type. (23703575)
2013
6
Earlier diagnosis of constipation would cut emergency admissions. (24067034)
2013
7
Prevalence and impact of constipation and bowel dysfunction induced by strong opioids: a cross-sectional survey of 520 patients with cancer pain: DYONISOS study. (24102123)
2013
8
Voiding dysfunction in children with chronic functional constipation. (24072141)
2013
9
The effect of parathyroidectomy on chronic constipation in patients affected by primary hyperparathyroidism. (23563978)
2013
10
A man with oral lesions, constipation and back pain. (24352119)
2013
11
Use of Rome II vs. Rome III Criteria for Diagnosis of Functional Constipation in Young Children. (23937604)
2013
12
Colectomy for slow transit constipation: effective for patients with coexistent obstructed defecation. (23525467)
2013
13
Pediatric ovarian dysgerminoma presenting with hypercalcemia and chronic constipation: a case report. (23799522)
2013
14
Constipation and pelvic outlet obstruction. (24280404)
2013
15
Physical inactivity, water intake and constipation as risk factors for colorectal cancer among adults in Jordan. (24175802)
2013
16
Prevalence, clinical characteristics, and management of functional constipation at pediatric gastroenterology clinics. (24015043)
2013
17
"Bowel obsession syndrome" in a patient with chronic constipation. (22717088)
2013
18
Does lack of glottic closure affect quality of life as a cause of constipation in laryngectomized patients? (23008127)
2013
19
A cross-sectional study of constipation and laxative use in advanced cancer patients: insights for revision of current practice. (22653368)
2013
20
A case of cecal volvulus presenting with chronic constipation in lissencephaly. (24010118)
2013
21
The use of abdominal muscle training, breathing exercises and abdominal massage to treat paediatric chronic functional constipation. (23375005)
2013
22
Clinical findings of functional and secondary constipation in children. (23795262)
2013
23
Transabdominal electrical stimulation increases colonic propagating pressure waves in paediatric slow transit constipation. (23217889)
2012
24
Constipation is also an important cause of fecal incontinence in old people. (22837887)
2012
25
Constipation Is Also an Important Cause of Fecal Incontinence in Old People: Author's Reply. (22837888)
2012
26
A prospective, randomized, single-blind comparison of laparoscopic versus open colectomy for slow-transit constipation. (22472413)
2012
27
Hyperhomocysteinemia decreases intestinal motility leading to constipation. (22595990)
2012
28
Methylnaltrexone for opioid-induced constipation in a pediatric oncology patient. (22770490)
2012
29
Internal anal sphincter relaxation associated with bisacodyl-induced colonic high amplitude propagating contractions in children with constipation: a colo-anal reflex? (22757618)
2012
30
Investigation of attention via the counting Stroop task in patients with functional constipation. (22490408)
2012
31
A review and additional post-hoc analyses of the incidence and impact of constipation observed in darifenacin clinical trials. (23055780)
2012
32
Effect of colic vein ligature in rats with loperamide-induced constipation. (22649279)
2012
33
Constipation--presenting compliant and clinical marker of Parkinson's disease. (22545352)
2012
34
Concurrent conditions in patients with chronic constipation: a population-based study. (23071488)
2012
35
Assessment and management of constipation in older people. (22792697)
2012
36
Long-term effects of transabdominal electrical stimulation in treating children with slow-transit constipation. (22152871)
2011
37
Is there an association between wheezing and constipation in preschool children? Explanations from a longitudinal birth cohort. (22021889)
2011
38
Go with the flow: in childhood constipation. (22132564)
2011
39
Constipation-associated and nonretentive fecal incontinence in children and adolescents: an epidemiological survey in Sri Lanka. (20562725)
2010
40
Lubiprostone: in constipation-predominant irritable bowel syndrome. (19537839)
2009
41
Pilot study of pyridostigmine in constipated patients with autonomic neuropathy. (18622640)
2008
42
Sacral nerve stimulation for fecal incontinence and constipation in adults: a short version Cochrane review. (18314865)
2008
43
Resection rectopexy for external rectal prolapse reduces constipation and anal incontinence. (17461314)
2007
44
Chronic constipation as a causative factor for development of varicocele in men: a prospective ultrasonographic study. (17182703)
2007
45
Methemoglobinemia caused by the ingestion of courgette soup given in order to resolve constipation in two formula-fed infants. (16809905)
2006
46
Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon. (12404220)
2002
47
Chronic constipation--a lethal danger in patients with systemic scleroderma. (11785605)
2001
48
Intestinal perforation in Ehlers-Danlos syndrome after enema treatment for constipation. (9822331)
1998
49
Effect of oral erythromycin on colonic transit in patients with idiopathic constipation. A pilot study. (7587829)
1995
50
Constipation and megacolon in rats related to treatment with oxodipine, a calcium antagonist. (7732276)
1994

Genetic Variations for Constipation

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Expression for genes affiliated with Constipation

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Constipation

Search GEO for disease gene expression data for Constipation.

Pathways for genes affiliated with Constipation

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Constipation

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Constipation according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1phentolamine28 44 1112.8ADRA2A, TAC1, VIP, PYY
2kassinin28 4411.8TACR2, TAC1, TAC3
3spantide4410.8TACR2, TAC1, PDYN, VIP
4thiorphan44 28 1112.8TAC3, VIP, TACR2, TAC1
5eledoisin44 2811.8TAC3, TAC1, TACR2
6septide44 2811.8TACR2, TAC3, TAC1
7gnrh4410.8HTR4, TAC3, PDYN, PYY, VIP
8senktide44 59 2812.8TACR2, TAC3, TAC1
9capsaicin44 2811.8VIP, TAC1, TACR2, PDYN, TAC3
10hexamethonium44 2811.8VIP, PYY, TACR2
11phosphoramidon44 1111.8PDYN, VIP, TACR2, TAC1
126-hydroxydopamine4410.8PDYN, NRTN, TAC1, VIP
13tetrodotoxin44 59 2812.8PYY, MLN, TAC1, TAC3, TACR2, VIP
14aequorin4410.8TAC1, MLN, MLNR
15chloride4410.8VIP, TAC1, AQP3, AQP4, CLCN2, TACR2
16guanethidine44 1111.8VIP, TAC1, TACR2
17bestatin44 28 59 1113.8PDYN, TAC1, TAC3
18oxyntomodulin44 5911.8VIP, PYY, MLN
195-hydroxytryptamine4410.8MLN, TDO2, PYY, TACR2, TAC1, VIP
20mepyramine44 1111.8TAC1, TAC3, TACR2
21cisapride44 28 1112.8MLNR, MLN, HTR4
22atropine44 28 1112.8HTR4, PDYN, TAC3, TACR2, PYY, VIP
23dopamine44 28 11 2413.8TAC1, ADRA2A, TAC3, NRTN, MLN, MLNR
24acth4410.8PDYN, PYY, MLN, HTR4, VIP
25histamine44 28 2412.8TACR2, TAC1, VIP, MLN, AQP4, PYY
26acetylcholine44 49 28 11 2414.8MLN, NRTN, TAC1, TACR2, TAC3, VIP
27nepadutant44 2811.7TAC1, TACR2
28ondansetron44 49 11 2413.7HTR4, TAC1, MLN
29cyclo(gln-trp-phe-gly-leu-met)4410.7TACR2, TAC1
30gr 1598975910.7TACR2, TAC1
31glutamate4410.7TACR2, TAC1, AQP4, NRTN, HTR4, VIP
32men 1037644 59 2812.7TAC1, TACR2
33arginine4410.7TDO2, TACR2, TAC1, MLN, HTR4, PDYN
34gr 948005910.7TAC1, TACR2
35[lys5,meleu9,nle10]-nka(4-10)5910.7TAC1, TACR2
36adenylate4410.7ADRA2A, VIP, MLN, TAC1, AQP3, PDYN
37gr 643495910.7TAC1, TACR2
38tyrosine4410.7NRTN, ADRA2A, VIP, PDYN, TDO2, PYY
39em 5234410.7MLN, MLNR
40norepinephrine44 11 2412.6VIP, PDYN, TAC1, PYY, ADRA2A
41nifedipine44 49 28 1113.6TACR2, MLN, VIP, TAC1
42cp 963454410.6TACR2, TAC1
43yohimbine44 28 2 1113.6ADRA2A, HTR4, PYY
44gr 712514410.6TAC1, TACR2
45carbachol44 28 1112.5PYY, TAC3, VIP, TAC1
46omeprazole44 28 49 11 2414.5MLN, CLCN2, PYY
47physalaemin44 2811.4TAC1, TAC3
48potassium44 11 2412.4VIP, PDYN, TAC1, AQP4, TACR2
49gr 823344410.3TAC1, TACR2
50osanetant28 4411.1TACR2, TAC1

GO Terms for genes affiliated with Constipation

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16Gene Ontology
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Cellular components related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00591110.4AQP7, AQP4, AQP3
2extracellular regionGO:00557610.3TAC3, VIP, PYY, PDYN, MLN, NRTN
3plasma membraneGO:00588610.2PDYN, HTR4, MLNR, CLCN2, TAC1, TACR2
4integral to plasma membraneGO:00588710.1HTR4, MLNR, TACR2, ADRA2A, AQP4, AQP7

Biological processes related to Constipation according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1renal water absorptionGO:07029510.6AQP7, AQP4, AQP3
2excretionGO:00758810.5TACR2, AQP3, AQP4, AQP7
3tachykinin receptor signaling pathwayGO:00721710.5TACR2, TAC3, TAC1
4neuropeptide signaling pathwayGO:00721810.4TAC3, TAC1, PDYN
5G-protein coupled receptor signaling pathwayGO:00718610.4VIP, PYY, HTR4, MLNR, MLN, ADRA2A
6water transportGO:00683310.3AQP7, AQP4, AQP3
7female pregnancyGO:00756510.1TAC3, ADRA2A, AQP4

Molecular functions related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.5PYY, VIP
2water channel activityGO:01525010.3AQP7, AQP3
3hormone activityGO:00517910.1MLN, PYY, VIP

Products for genes affiliated with Constipation

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Sources for Constipation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet