MCID: CNS004
MIFTS: 54

Constipation malady

Gastrointestinal diseases category
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Summaries for Constipation

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MedlinePlus:33 Constipation means that a person has three or fewer bowel movements in a week. the stool can be hard and dry. sometimes it is painful to pass. at one time or another, almost everyone gets constipated. in most cases, it lasts a short time and is not serious. there are many things you can do to prevent constipation. they include eating more fruits, vegetables and grains, which are high in fiber drinking plenty of water and other liquids getting enough exercise taking time to have a bowel movement when you need to using laxatives only if your doctor says you should asking your doctor if medicines you take may cause constipation it's not important that you have a bowel movement every day. if your bowel habits change, however, check with your doctor. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Constipation is related to hirschsprung's disease and morbid obesity. An important gene associated with Constipation is CLCN2 (chloride channel, voltage-sensitive 2), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Peptide ligand-binding receptors. The compounds thiorphan and captopril have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and testes, and related mouse phenotypes are vision/eye and normal.

Wikipedia:65 Constipation (also known as costiveness or dyschezia) refers to bowel movements that are infrequent or... more...

Aliases & Classifications for Constipation

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Constipation, Aliases & Descriptions:

Name: Constipation 8 10 33


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:2089
ICD9CM27 564.00, 564.0
NCIt39 C37930
MeSH34 D003248
ICD1025 K59.0

Related Diseases for Constipation

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Graphical network of the top 20 diseases related to Constipation:



Diseases related to constipation

Symptoms for Constipation

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Drugs & Therapeutics for Constipation

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Drug clinical trials:

Search ClinicalTrials for Constipation

Search NIH Clinical Center for Constipation

Genetic Tests for Constipation

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Anatomical Context for Constipation

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MalaCards organs/tissues related to Constipation:

32
Colon, Kidney, Testes, Ovary, Small intestine, Prostate, Spinal cord, Spleen, Brain, Heart, Smooth muscle

Animal Models for Constipation or affiliated genes

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MGI Mouse Phenotypes related to Constipation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8CLCN2, AQP3, NRTN, TDO2
2MP:00028738.6TAC3, ADRA2A, VIP, PYY
3MP:00036318.3TDO2, NRTN, ADRA2A, CLCN2, PYY
4MP:00053798.2CLCN2, AQP7, VIP, NRTN
5MP:00053867.0TDO2, PYY, CLCN2, AQP3, VIP, ADRA2A
6MP:00053766.9PYY, CLCN2, AQP7, AQP3, VIP, ADRA2A

Publications for Constipation

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Articles related to Constipation:

(show top 50)    (show all 711)
idTitleAuthorsYear
1
Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation. (25390617)
2014
2
Clinical and investigative assessment of constipation: A study from a referral center in western India. (25316170)
2014
3
Finger taps and constipation are closely related to symptoms of overactive bladder in male patients with Parkinson's disease. (23659545)
2014
4
Review article: linaclotide for the management of irritable bowel syndrome with constipation. (24433216)
2014
5
Management of faecal incontinence and constipation in adults with central neurological diseases. (24420006)
2014
6
Colonic electrical stimulation for the treatment of slow-transit constipation: a preliminary pilot study. (24048815)
2013
7
Interferential therapy: a new treatment for slow transit constipation. a pilot study in adults. (23046450)
2013
8
Clinical and psychosocial functioning in adolescents and young adults with anorectal malformations and chronic idiopathic constipation. (23553758)
2013
9
Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation. (24007408)
2013
10
Linaclotide-a novel secretagogue in the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (24001336)
2013
11
The use of prucalopride in real life for the treatment of constipation subtypes: ups and downs. (23703576)
2013
12
Association of constipation and fecal incontinence with attention-deficit/hyperactivity disorder. (24144702)
2013
13
Strumal carcinoid tumour of the ovary presenting with severe constipation. (23338927)
2013
14
In-hospital costs associated with chronic constipation in Belgium: a retrospective database study. (24325294)
2013
15
Chronic constipation. (23943571)
2013
16
The efficacy and safety study of electro-acupuncture for severe chronic functional constipation: study protocol for a multicenter, randomized, controlled trial. (23768191)
2013
17
Sacral nerve stimulation for constipation (Br J Surg 2013; 100: 174-181). (23239479)
2013
18
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
19
Impact of persistent constipation on health-related quality of life and mortality in older community-dwelling women. (23670115)
2013
20
Management of functional constipation in children with lower urinary tract symptoms: report from the Standardization Committee of the International Children's Continence Society. (23313210)
2013
21
The Self-Report Fecal Incontinence and Constipation Questionnaire in Patients With Pelvic-Floor Dysfunction Seeking Outpatient Rehabilitation. (24114438)
2013
22
Effect of dietary fiber on constipation: a meta analysis. (23326148)
2012
23
Celiac disease is overrepresented in patients with constipation. (22434186)
2012
24
Constipation and aspiration pneumonia. (22712814)
2012
25
Re: oral docusate in the management of constipation in hospice patients. (23217455)
2012
26
Transabdominal electrical stimulation increases colonic propagating pressure waves in paediatric slow transit constipation. (23217889)
2012
27
Chronic constipation due to delayed diagnosis of a congenital anal web. (22271242)
2012
28
Constipation is a major complication after posterior sagittal anorectoplasty for anorectal malformations in children. (22964283)
2012
29
Development and assessment of the constipation-related disability scale. (22248425)
2012
30
OTC polyethylene glycol 3350 and pharmacists' role in managing constipation. (22618979)
2012
31
Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation. (21585622)
2011
32
The pathophysiology of chronic constipation. (22114753)
2011
33
Chronic constipation may signify higher risk of heart disease. If you suffer from chronic constipation, see your cardiologist. (23019713)
2011
34
Managing functional constipation in children. (23204909)
2011
35
A topic in 10 questions: how to manage infant constipation. (22132562)
2011
36
Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. (20691689)
2010
37
Use of the chloride channel activator lubiprostone for constipation in adults with cystic fibrosis: a case series. (20179256)
2010
38
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
39
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
40
Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation. (15688149)
2005
41
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon. (16048580)
2005
42
Pathology of chronic constipation in pediatric and adult coloproctology. (15902901)
2005
43
May chronic childhood constipation cause oxidative stress and potential free radical damage to children? (15602823)
2004
44
The constipated child: how likely is Hirschsprung's disease? (12698267)
2003
45
Chronic constipation--a lethal danger in patients with systemic scleroderma. (11785605)
2001
46
Effects of erythromycin on human colonic circular muscle in idiopathic chronic constipation. (10620004)
2000
47
Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation. (10027360)
1999
48
Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. (9129468)
1997
49
Function of the striated anal sphincter during straining in control subjects and constipated patients with a radiologically normal rectum or idiopathic megacolon. (3198990)
1988
50
Letter: Constipation: a cause of urinary tract obstruction and infection. (1246799)
1976

Variations for Constipation

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Expression for genes affiliated with Constipation

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Expression patterns in normal tissues for genes affiliated with Constipation

Search GEO for disease gene expression data for Constipation.

Pathways for genes affiliated with Constipation

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Pathways related to Constipation according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4ADRA2A, PYY
2
Show member pathways
9.1TAC3, ADRA2A, PYY
3
Show member pathways
9.0AQP7, AQP3
4
Show member pathways
8.7AQP3, AQP7, CLCN2

Compounds for genes affiliated with Constipation

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Compounds related to Constipation according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1thiorphan44 28 1112.0VIP, TAC3
2captopril44 61 50 28 1114.0VIP, TAC3
36-hydroxydopamine4410.0VIP, NRTN
4omeprazole44 50 28 24 1114.0CLCN2, PYY
5capsaicin44 2810.9VIP, TAC3
6hexamethonium44 2810.9VIP, PYY
7oxyntomodulin44 6110.8PYY, VIP
8bromocriptine44 28 1111.8VIP, ADRA2A
9yohimbine44 2 28 1112.8ADRA2A, PYY
10amiloride44 28 1111.8ADRA2A, VIP
11octreotide44 61 28 1112.7VIP, PYY
12clonidine44 50 28 1112.7ADRA2A, PYY
13phenylephrine44 28 24 1112.7ADRA2A, VIP
14propranolol44 28 50 24 1113.6VIP, PYY
15melatonin44 28 61 24 1113.6TDO2, VIP
16ornithine44 2410.5TDO2, PYY
17atropine44 28 1111.5TAC3, VIP, PYY
18choline44 24 1111.5VIP, ADRA2A, NRTN
19tetrodotoxin44 61 2811.5PYY, VIP, TAC3
20carbachol44 28 1111.5PYY, VIP, TAC3
215-hydroxytryptamine449.5TDO2, VIP, PYY
22chloride449.4VIP, AQP3, CLCN2
23hg2+289.4AQP3, AQP7
24haloperidol44 50 28 2 1113.4PYY, VIP
25phentolamine44 28 1111.4ADRA2A, VIP, PYY
26isoproterenol44 1110.3ADRA2A, VIP, PYY
27norepinephrine44 24 1111.3PYY, VIP, ADRA2A
28aspartate449.3VIP, ADRA2A, TDO2
29catecholamine449.2ADRA2A, VIP
30acetylcholine44 50 28 24 1113.2PYY, VIP, NRTN, TAC3
31cyclic amp44 2410.0ADRA2A, VIP, PYY
32gnrh449.0TAC3, ADRA2A, VIP, PYY
33adenylate449.0AQP3, VIP, ADRA2A
34estrogen448.9TAC3, ADRA2A, VIP, PYY
35forskolin44 50 1110.9VIP, AQP3, AQP7
36dopamine44 28 24 1111.7PYY, VIP, ADRA2A, NRTN, TAC3
37tyrosine448.2PYY, VIP, ADRA2A, NRTN, TAC3, TDO2

GO Terms for genes affiliated with Constipation

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Cellular components related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:0059119.0AQP3, AQP7
2extracellular regionGO:0055768.5TAC3, NRTN, VIP, PYY

Biological processes related to Constipation according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:0459099.6ADRA2A, VIP
2female pregnancyGO:0075659.5TAC3, ADRA2A
3cellular component movementGO:0069289.4ADRA2A, PYY
4renal water absorptionGO:0702959.2AQP3, AQP7
5water transportGO:0068339.1AQP3, AQP7
6G-protein coupled receptor signaling pathwayGO:0071869.1PYY, VIP, ADRA2A
7excretionGO:0075889.0AQP7, AQP3
8transmembrane transportGO:0550858.4AQP3, AQP7, CLCN2

Molecular functions related to Constipation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5VIP, PYY
2neuropeptide hormone activityGO:0051849.2VIP, PYY
3water channel activityGO:0152508.9AQP3, AQP7

Products for genes affiliated with Constipation

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  • Antibodies
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Sources for Constipation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet