MCID: CNS004
MIFTS: 56

Constipation

Categories: Gastrointestinal diseases

Aliases & Classifications for Constipation

MalaCards integrated aliases for Constipation:

Name: Constipation 12 29 41 42 14

Classifications:



Summaries for Constipation

MedlinePlus : 41 constipation means that a person has three or fewer bowel movements in a week. the stool can be hard and dry. sometimes it is painful to pass. at one time or another, almost everyone gets constipated. in most cases, it lasts a short time and is not serious. there are many things you can do to prevent constipation. they include eating more fruits, vegetables and grains, which are high in fiber drinking plenty of water and other liquids getting enough exercise taking time to have a bowel movement when you need to using laxatives only if your doctor says you should asking your doctor if medicines you take may cause constipation it's not important that you have a bowel movement every day. if your bowel habits change, however, check with your doctor. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Constipation is related to hirschsprung disease 1 and central hypoventilation syndrome, congenital. An important gene associated with Constipation is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Methylnaltrexone and Naltrexone have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related phenotypes are Decreased viability and behavior/neurological

Disease Ontology : 12 A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces.

Wikipedia : 72 Constipation refers to bowel movements that are infrequent or hard to pass. The stool is often hard and... more...

Related Diseases for Constipation

Diseases related to Constipation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
id Related Disease Score Top Affiliating Genes
1 hirschsprung disease 1 31.8 EDNRB GDNF RET
2 central hypoventilation syndrome, congenital 31.7 EDNRB GDNF RET
3 intestinal volvulus 31.6 PYY SST VIP
4 typhoid fever 30.3 CCK GAST HTR3A SST
5 dyspepsia 30.1 CCK TAC1
6 paralytic ileus 29.8 EDNRB FLNA GDNF RET
7 chagas disease 28.9 CCK HTR3A PYY SLC6A4
8 outlet dysfunction constipation 11.9
9 coarse face hypotonia constipation 11.8
10 irritable bowel syndrome 11.2
11 fecal incontinence 11.1
12 porphyria 11.1
13 intestinal pseudo-obstruction 11.0
14 caudal regression syndrome 11.0
15 colonic pseudo-obstruction 10.9
16 intestinal obstruction 10.9
17 colorectal cancer 10.9
18 hemorrhoid 10.9
19 hypoganglionosis 10.8
20 peritonitis 10.8
21 rett syndrome 10.8
22 adrenomyodystrophy 10.8
23 ulcerative proctitis 10.8
24 celiac disease 10.8
25 disseminated peritoneal leiomyomatosis 10.8
26 pitt-hopkins syndrome 10.8
27 multiple endocrine neoplasia iib 10.8
28 megalocytic interstitial nephritis 10.8 GDNF RET
29 wegmann jones smith syndrome 10.7 SST VIP
30 hypogonadotropic hypogonadism without anosmia, x-linked 10.7 GDNF RET
31 fg syndrome 4 10.7
32 opitz-kaveggia syndrome 10.7
33 urofacial syndrome 1 10.7
34 fg syndrome 2 10.7
35 neuropathy, hereditary sensory and autonomic, type vii 10.7
36 tarlov cysts 10.7
37 diabetes mellitus, noninsulin-dependent, 5 10.6 EDNRB RET
38 wolffian duct adenocarcinoma 10.6 EDNRB GDNF RET
39 shprintzen-goldberg syndrome 10.6 EDNRB GDNF RET
40 vestibulocochlear nerve disease 10.5 GDNF RET SST
41 focal hand dystonia 10.5 TAC1 VIP
42 laminopathy type decaudain-vigouroux 10.5 TAC1 TACR1
43 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 10.5
44 hypothyroidism 10.5
45 paroxysmal extreme pain disorder 10.5
46 osmotic diarrhea 10.5
47 hashimoto thyroiditis 10.5
48 pelvic lipomatosis 10.5
49 appendicitis 10.5
50 autoimmune autonomic ganglionopathy 10.5

Graphical network of the top 20 diseases related to Constipation:



Diseases related to Constipation

Symptoms & Phenotypes for Constipation

GenomeRNAi Phenotypes related to Constipation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 HTR3A MLN SLC6A4
2 Decreased viability GR00381-A-3 9.1 HTR3A MLN SLC6A4

MGI Mouse Phenotypes related to Constipation:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.41 TACR1 VIP CCK CLCN2 EDNRB FLNA
2 homeostasis/metabolism MP:0005376 10.24 TACR1 VIP CCK CLCN2 EDNRB FLNA
3 endocrine/exocrine gland MP:0005379 10.23 CCK CLCN2 EDNRB GAST GDNF HTR3A
4 growth/size/body region MP:0005378 10.21 SST TCF4 EDNRB FLNA GDNF HTR3A
5 cardiovascular system MP:0005385 10.19 TACR1 VIP CLCN2 EDNRB FLNA GDNF
6 digestive/alimentary MP:0005381 10.13 CLCN2 EDNRB FLNA GAST GDNF KIT
7 immune system MP:0005387 10.13 TACR1 TCF4 VIP CLCN2 EDNRB FLNA
8 mortality/aging MP:0010768 10.07 EDNRB FLNA GAST GDNF HTR3A HTR4
9 hematopoietic system MP:0005397 10.06 CLCN2 FLNA GDNF HTR3A KIT OPRM1
10 nervous system MP:0003631 10.03 CCK CLCN2 EDNRB FLNA GDNF HTR3A
11 normal MP:0002873 9.61 FLNA KIT OPRM1 PYY RET SLC6A4
12 renal/urinary system MP:0005367 9.1 EDNRB GDNF HTR3A KIT RET TAC1

Drugs & Therapeutics for Constipation

Drugs for Constipation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 544)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylnaltrexone Approved Phase 4,Phase 2,Phase 3 83387-25-1, 916055-93-1 6603824
2
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 16590-41-3 5360515
3
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2 465-65-6 5284596
4
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 76-42-6 5284603
5
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
6
Oxybutynin Approved, Investigational Phase 4,Phase 3 5633-20-5 4634
7
Amitriptyline Approved Phase 4 50-48-6 2160
8
Cyclobenzaprine Approved Phase 4 303-53-7 2895
9
Ropivacaine Approved Phase 4,Phase 3,Phase 2 84057-95-4 71273 175805
10
Lubiprostone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 136790-76-6 656719
11
Bisacodyl Approved Phase 4,Phase 3,Phase 2 603-50-9
12
Lactulose Approved Phase 4,Phase 3,Phase 2,Phase 1 4618-18-2 11333
13
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
15
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
16
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
17
Loperamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53179-11-6 3955
18
Magnesium oxide Approved Phase 4,Phase 2 1309-48-4 14792
19
Bismuth Subsalicylate Approved, Vet_approved Phase 4,Phase 3,Phase 2 14882-18-9 53629521
20
Magnesium Hydroxide Approved Phase 4,Phase 2 1309-42-8
21
Naloxegol Approved Phase 4,Phase 3,Phase 2,Phase 1 854601-70-0
22
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
23
Sorbitol Approved Phase 4,Phase 3 50-70-4 5780
24
Celecoxib Approved, Investigational Phase 4,Phase 1 169590-42-5 2662
25
Hydromorphone Approved, Illicit Phase 4,Phase 2,Phase 3 466-99-9 5284570
26
Ibuprofen Approved Phase 4,Phase 1 15687-27-1 3672
27
Ondansetron Approved Phase 4 99614-02-5 4595
28
Octreotide Approved, Investigational Phase 4,Phase 2,Phase 1 83150-76-9 383414 6400441
29
Coal tar Approved Phase 4,Phase 3 8007-45-2
30
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
31
Propranolol Approved, Investigational Phase 4 525-66-6 4946
32
Topiramate Approved Phase 4,Phase 2 97240-79-4 5284627
33
Desflurane Approved Phase 4 57041-67-5 42113
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
35
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
36
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
37
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
38
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
39
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
40
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
41
Diltiazem Approved Phase 4,Phase 3,Phase 1 42399-41-7 39186
42 Mirabegron Approved Phase 4,Phase 3 223673-61-8
43
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
44
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
45
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
46
Alvimopan Approved Phase 4,Phase 3,Phase 2 156053-89-3 5488548
47 Magnesium citrate Approved Phase 4
48
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
49
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
50
Orphenadrine Approved Phase 4 83-98-7 4601

Interventional clinical trials:

(show top 50) (show all 962)

id Name Status NCT ID Phase Drugs
1 Study Evaluating The Safety Of Subcutaneous Methylnaltrexone In Treatment Of Opioid-Induced Constipation Unknown status NCT00672139 Phase 4 Methylnaltrexone bromide
2 Lactobacillus Reuteri in Children With Constipation Unknown status NCT01388712 Phase 4
3 Polyethylene Glycol (PEG) Versus Sennosides Study in Opioid-Induced Constipation in Cancer Patients Unknown status NCT01189409 Phase 4 PEG then Senna;Senna then PEG
4 Polyethylene Glycol for Childhood Constipation Unknown status NCT01875744 Phase 4 Polyethylene glycol 4000
5 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4 Mosapride
6 A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy Unknown status NCT01109511 Phase 4 naloxone;oxycodone
7 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
8 A Trial Comparing Bowel Preparation and Patient Tolerability of Miralax Versus Golytely Unknown status NCT00889655 Phase 4 Golytely (polyethylene glycol);MiraLax (polyethylene glycol 3350)
9 The Use of Botox in Advanced Parkinson's Patients Experiencing Pain Unknown status NCT02472210 Phase 4 Botulinum Toxin
10 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
11 Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele Unknown status NCT00175123 Phase 4 Botulinum A toxin
12 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
13 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
14 A Non-interventional, Observational Study for Quality of Life (Overall Health Assessment) in Patients With Chronic Severe Pain During Targinact® Treatment Unknown status NCT01710917 Phase 4 Targinact® (oxycodon/naloxon)
15 Transversus Abdominis Plane Blocks With Abdominoplasty Unknown status NCT01278264 Phase 4 Ropivacaine 0.25%, 0.5 ml/kg;Ropivacaine 0.25%, 0.5 ml/kg
16 A Study to Assess Different Diagnostic Criteria of Chronic Constipation in Asia Completed NCT01880294 Phase 4 No intervention
17 An Observational Study to Evaluate the Quality of Life in Korean Female Participants With Chronic Constipation Completed NCT01902537 Phase 4 Prucalopride; observational study
18 Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation Completed NCT02147574 Phase 4
19 Comparison of Lubiprostone and Placebo for the Relief of Constipation From Constipating Medications Completed NCT01096290 Phase 4 lubiprostone;Matched placebo
20 Lubiprostone in Patients With Multiple Sclerosis Associated Constipation Completed NCT01236534 Phase 4 Lubiprostone;Placebo
21 The Effect of Probiotics on Constipation, and Intestinal Microflora in Children With Functional Constipation Completed NCT03054805 Phase 4 Magnesium Oxide;MIYAIRI-BM
22 Methylnaltrexone Use for Opioid-induced Postoperative Constipation Completed NCT01773096 Phase 4 Methylnaltrexone;Senna, docusate sodium, bisacodyl, magnesium hydroxide, Miralax
23 Polyethyleneglycol3350 vs Tegaserod in Treatment of Patients With Chronic Constipation Completed NCT00153140 Phase 4 polyethyleneglycol3350
24 Soy Polysaccharide Fiber for the Treatment of Chronic Constipation in Children: a Randomized, Double-blind Trial Completed NCT01267370 Phase 4
25 Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced Illness Completed NCT00672477 Phase 4 Methylnaltrexone bromide;Placebo
26 Evaluation of Long-term Prucalopride Treatment With Chronic Constipation in Subjects Aged ≥ 18 Years Completed NCT01424228 Phase 4 placebo;prucalopride
27 Efficacy and Safety of Prucalopride in Combination With Polyethylene Glycol or Lactulose in Women With Chronic Constipation Completed NCT02228616 Phase 4 Prucalopride;Polyethylene glycol (PEG);Lactulose
28 Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children Completed NCT01592734 Phase 4 Polyethylene glycol with electrolytes
29 Preference of Tegaserod vs. PEG 3350 in Patients With Constipation Completed NCT00171522 Phase 4 Tegaserod and Polyethylene Glycol 3350
30 Comparison of PEG Solutions With and Without Electrolytes in the Treatment of Constipation Completed NCT00603681 Phase 4 Polyethylene glycol 4000;Polyethylene glycol 4000 with electrolytes
31 Lactobacillus Reuteri DSM 17938 in Functional Constipation Completed NCT01244945 Phase 4
32 Efficacy, Safety and Tolerability of Tegaserod in Patients With Chronic Constipation Completed NCT00149877 Phase 4 Tegaserod
33 Safety and Efficacy of Lubiprostone in Pediatric Patients With Constipation Completed NCT00452335 Phase 4 Lubiprostone;Lubiprostone;Lubiprostone
34 The Efficacy of Mutaflor(E. Coli Nissle 1917, Mutaflor®) for Chronic Constipation:Multicenter Study Completed NCT02726295 Phase 4 E. coli Nissle 1917(Mutaflor®);Placebo
35 Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications Completed NCT00153127 Phase 4 polyethyleneglycol3350
36 Dietary Fiber Mixture in Constipated Pediatric Patients Completed NCT01333787 Phase 4
37 To Evaluate Patient Preference of Movantik and Polyethylene Glycol 3350 for Opioid Induced Constipation Completed NCT03060512 Phase 4 Polyethylene Glycol 3350;Movantik
38 A Pilot Study of a New MiraLax® Dose Formulation For Use in Constipated Children Completed NCT00319670 Phase 4 MiraLax
39 Lcr35 for Children With Functional Constipation Completed NCT01985867 Phase 4
40 Extended Use of Polyethyleneglycol3350 Laxative in Constipated Patients Completed NCT00153153 Phase 4 polyethyleneglycol3350
41 Study Comparing PEG 3350 Laxative to Placebo in the Treatment of Occasional Constipation (Study CL2007-12)(P08216) Completed NCT00770432 Phase 4 Polyethylene glycol 3350
42 The Effectiveness of Lubiprostone in Constipated Diabetics Completed NCT01170039 Phase 4 Lubiprostone;Placebo
43 An Open Label Study of Chronic Polyethyleneglycol3350 Use in Constipated Patients Completed NCT00164125 Phase 4 polyethyleneglycol3350
44 A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC). Completed NCT01957046 Phase 4 Laxative
45 Effects of Lubiprostone on Gastric Function in Patients With Chronic Idiopathic Constipation Completed NCT01460225 Phase 4 lubiprostone
46 Investigation of Dried Plums in the Treatment of Adults With Constipation Completed NCT01180725 Phase 4
47 PolyethyleneGlycol3350 Laxative vs Placebo in Constipated Children Completed NCT00153114 Phase 4 polyethyleneglycol3350
48 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4
49 A Study to Compare the Effect of Transipeg 2.95 g or Forlax Junior 4 g in Children With Constipation Completed NCT01810653 Phase 4 Macrogol (Transipeg, BAY81-8430);Macrogol (Forlax)
50 Amitiza in Constipation Associated With PD (Parkinson's Disease) Completed NCT00908076 Phase 4 LUBIPROSTONE

Search NIH Clinical Center for Constipation

Cochrane evidence based reviews: constipation

Genetic Tests for Constipation

Genetic tests related to Constipation:

id Genetic test Affiliating Genes
1 Constipation 29

Anatomical Context for Constipation

MalaCards organs/tissues related to Constipation:

39
Colon, Testes, Kidney, Spinal Cord, Lung, Liver, Brain

Publications for Constipation

Articles related to Constipation:

(show top 50) (show all 870)
id Title Authors Year
1
A case of sulfhemoglobinemia in a child with chronic constipation. ( 28348950 )
2017
2
What is the diagnostic yield of colonoscopy in patients with a referral diagnosis of constipation in South Africa? ( 28876560 )
2017
3
A retrospective audit on usage of Diatrizoate Meglumine (Gastrografin(Ar)) for intestinal obstruction or constipation in patients with advanced neoplasms. ( 28805119 )
2017
4
Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. ( 28799195 )
2017
5
Drugs for treating opioid-induced constipation: A mixed treatment comparison network meta-analysis of randomized controlled clinical trials. ( 28919541 )
2017
6
Quantifying traditional Chinese medicine patterns using modern test theory: an example of functional constipation. ( 28086767 )
2017
7
Polyethylene Glycol 3350 With Electrolytes vs Polyethylene Glycol 4000 for Constipation: A Randomized, Controlled Trial. ( 28906317 )
2017
8
Endoscopic Mucosal Resection is Superior to Rectal Suction Biopsy for Analysis of Enteric Ganglia in Constipation and Dysmotility. ( 28893560 )
2017
9
Enuresis and Constipation in a 12-Year-Old. ( 28952347 )
2017
10
Chronic constipation diagnosis and treatment evaluation: the "CHRO.CO.DI.T.E." study. ( 28088179 )
2017
11
Pelvic physiotherapy in addition to standard care is more effective than standard medical care alone for children with functional constipation [synopsis]. ( 28888690 )
2017
12
Constipation Is Related to Small Bowel Disturbance Rather Than Colonic Enlargement in Acquired Chagasic Megacolon. ( 28912906 )
2017
13
Physical activity may decrease the likelihood of children developing constipation. ( 28898506 )
2017
14
Reliability and validity of the Bowel Function Index for evaluating opioid-induced constipation: translation, cultural adaptation and validation of the Portuguese version (BFI-P). ( 27981871 )
2017
15
Pelvic physiotherapy in addition to standard care is more effective than standard medical care alone for children with functional constipation [commentary]. ( 28935518 )
2017
16
Optimizing the Use of Linaclotide in Patients with Constipation-Predominant Irritable Bowel Syndrome: An Expert Consensus Report. ( 28083815 )
2017
17
Dietary intake, physical activity, and time management are associated with constipation in preschool children in Japan. ( 28049271 )
2017
18
Supporting patients in reducing postoperative constipation: fundamental nursing care - a quasi-experimental study. ( 28881476 )
2017
19
Oral prolonged-release oxycodone/naloxone for managing pain and opioid-induced constipation: A review of the evidence. ( 28944983 )
2017
20
Bifidobacteria exert species-specific effects on constipation in BALB/c mice. ( 28884754 )
2017
21
Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats. ( 28066135 )
2017
22
Normative Values for Colonic Transit Time and Patient Assessment of Constipation in Adults With Functional Constipation: Systematic Review With Meta-Analysis. ( 28894394 )
2017
23
Editorial: subgroups in irritable bowel syndrome-more than just diarrhoea and constipation? Authors' reply. ( 28880440 )
2017
24
Editorial: subgroups in irritable bowel syndrome-more than just diarrhoea and constipation? ( 28880445 )
2017
25
Depression but Not Symptom Severity is Associated With Work and School Absenteeism in Refractory Chronic Constipation. ( 28059936 )
2017
26
Contemporary short- and long-term outcomes in patients with unremitting constipation and fecal incontinence treated with an antegrade continence enema. ( 27817835 )
2017
27
Is-it possible to distinguish irritable bowel syndrome with constipation from functional constipation? ( 28066860 )
2017
28
Chronic refractory constipation due to neurogenic bowel dysfunction can be successfully treated by sacral neurostimulation. ( 28467281 )
2017
29
Stercoral perforation of the rectosigmoid colon due to chronic constipation: A case report. ( 28934715 )
2017
30
The overlap of gastroesophageal reflux disease and functional constipation in children: the efficacy of constipation treatment. ( 28914696 )
2017
31
More than constipation - bowel symptoms in Parkinson's disease and their connection to gut microbiota. ( 28891262 )
2017
32
Effect Of Prucalopride on Intestinal Gas Tolerance in Patients With Functional Bowel Disorders and Constipation. ( 28090679 )
2017
33
Addressing Opioid-Associated Constipation Using Quality Oncology Practice Initiative Scores and Plan-Do-Study-Act Cycles. ( 28084881 )
2017
34
Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt-Hopkins Syndrome. ( 28251008 )
2017
35
Treatment With Naloxegol Versus Placebo: Pain Assessment in Patients With Noncancer Pain and Opioid-Induced Constipation. ( 28898536 )
2017
36
Physiologic Management of Chronic Constipation: Let's FEED It. ( 28948409 )
2017
37
Effectiveness of percutaneous tibial nerve stimulation in managing refractory constipation. ( 27197580 )
2016
38
A Perspective on the Physical Therapy Management of Functional Constipation. ( 27634920 )
2016
39
The Efficacy of Functional Electrical Stimulation of the Abdominal Muscles in the Treatment of Chronic Constipation in Patients with Multiple Sclerosis: A Pilot Study. ( 27200190 )
2016
40
Abdominal Massage for the Relief of Constipation in People with Parkinson's: A Qualitative Study. ( 28090363 )
2016
41
Role Of Stretching Exercises In The Management Of Constipation In Spastic Cerebral Palsy. ( 28586619 )
2016
42
Use of prucalopride for chronic constipation: a systematic review and meta-analysis of published randomized, controlled trials. ( 27127190 )
2016
43
Urinary Retention due to Constipation. ( 27580563 )
2016
44
Characterization the response of Korl:ICR mice to loperamide induced constipation. ( 28053617 )
2016
45
Management of the clinical issue of constipation with abdominal complaints in adults. A national survey of Primary Care physicians and gastroenterologists. ( 27165279 )
2016
46
Characteristics of the Contrast Enema Do Not Predict an Effective Bowel Management Regimen for Patients with Constipation or Fecal Incontinence. ( 27688984 )
2016
47
Dyspepsia and constipation in patients with schizophrenia spectrum disorders. ( 27564411 )
2016
48
Approach to Constipation in Children. ( 27156546 )
2016
49
Gender, Age, and Prevalence of Pediatric Irritable Bowel Syndrome and Constipation in Colombia: A Population-Based Study. ( 27579696 )
2016
50
Phase II trial of subcutaneous methylnaltrexone in the treatment of severe opioid-induced constipation (OIC) in cancer patients: an exploratory study. ( 27628064 )
2016

Variations for Constipation

ClinVar genetic disease variations for Constipation:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic/Likely pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416

Expression for Constipation

Search GEO for disease gene expression data for Constipation.

GO Terms for Constipation

Cellular components related to Constipation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 CCK FLNA GAST GDNF MLN PYY
2 integral component of plasma membrane GO:0005887 9.87 EDNRB HTR4 MLNR OPRM1 RET SLC6A4
3 membrane raft GO:0045121 9.46 EDNRB OPRM1 RET SLC6A4
4 axon GO:0030424 9.35 CCK HTR3A OPRM1 RET TAC1
5 neuronal cell body GO:0043025 9.1 CCK FLNA HTR3A RET SST TAC1
6 plasma membrane GO:0005886 10.15 CLCN2 EDNRB FLNA HTR3A HTR4 KIT

Biological processes related to Constipation according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.96 MLN PYY SST TAC1
2 neuropeptide signaling pathway GO:0007218 9.81 OPRM1 PYY TAC1
3 chemical synaptic transmission GO:0007268 9.8 HTR4 OPRM1 SST TAC1 TACR1
4 regulation of blood pressure GO:0008217 9.78 EDNRB TAC1 TACR1
5 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.77 EDNRB OPRM1 TACR1
6 digestion GO:0007586 9.77 MLNR PYY SST
7 response to morphine GO:0043278 9.69 OPRM1 TAC1 TACR1
8 neural crest cell migration GO:0001755 9.67 EDNRB GDNF RET
9 mRNA stabilization GO:0048255 9.65 GDNF VIP
10 melanocyte differentiation GO:0030318 9.65 EDNRB KIT
11 regulation of sensory perception of pain GO:0051930 9.65 CCK EDNRB OPRM1
12 G-protein coupled receptor signaling pathway GO:0007186 9.65 EDNRB GAST HTR4 MLN MLNR OPRM1
13 vasoconstriction GO:0042310 9.64 EDNRB SLC6A4
14 positive regulation of ossification GO:0045778 9.63 TAC1 TACR1
15 eating behavior GO:0042755 9.63 CCK OPRM1 TACR1
16 developmental pigmentation GO:0048066 9.62 EDNRB KIT
17 positive regulation of synaptic transmission, GABAergic GO:0032230 9.62 TAC1 TACR1
18 regulation of appetite GO:0032098 9.61 HTR4 PYY
19 positive regulation of lymphocyte proliferation GO:0050671 9.58 TAC1 TACR1
20 tachykinin receptor signaling pathway GO:0007217 9.58 TAC1 TACR1
21 sperm ejaculation GO:0042713 9.57 SLC6A4 TACR1
22 positive regulation of action potential GO:0045760 9.56 TAC1 TACR1
23 sensory perception of pain GO:0019233 9.56 EDNRB OPRM1 TAC1 TACR1
24 positive regulation of synaptic transmission, cholinergic GO:0032224 9.55 TAC1 TACR1
25 detection of abiotic stimulus GO:0009582 9.54 TAC1 TACR1
26 positive regulation of renal sodium excretion GO:0035815 9.54 EDNRB TAC1 TACR1
27 positive regulation of saliva secretion GO:0046878 9.52 TAC1 TACR1
28 posterior midgut development GO:0007497 9.43 EDNRB RET
29 enteric nervous system development GO:0048484 9.33 EDNRB GDNF RET
30 response to pain GO:0048265 8.92 EDNRB RET TAC1 TACR1
31 positive regulation of cell proliferation GO:0008284 10.03 CCK EDNRB GDNF KIT VIP
32 signal transduction GO:0007165 10.02 CCK EDNRB GAST GDNF HTR4 KIT

Molecular functions related to Constipation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 GDNF KIT RET
2 neuropeptide hormone activity GO:0005184 9.13 CCK PYY VIP
3 hormone activity GO:0005179 9.1 CCK GAST MLN PYY SST VIP

Sources for Constipation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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