MCID: CNT047
MIFTS: 59

Contact Dermatitis malady

Skin diseases category

Summaries for Contact Dermatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Contact dermatitis is a type of skin inflammation (dermatitis) that results from exposure to allergens... more...

MalaCards: Contact Dermatitis, also known as contact dermatitis/eczema, is related to dermatitis and allergic contact dermatitis. An important gene associated with Contact Dermatitis is ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide), and among its related pathways are TGF-Beta Pathway and PAK Pathway. The drugs pramoxine and pramoxine hydrochloride and the compounds rantes and tarc have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells.

Aliases & Classifications for Contact Dermatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Contact Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Contact Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis32.2CCL27, CCL17, CCR4, CCL22, CCR10, FLG
2allergic contact dermatitis32.1CXCL10, FLG, CCL27, CCR4
3atopic dermatitis31.0IL31, CXCL10, FLG, CCL17, CCR4, CCL22
4psoriasis30.8LCE3C, LCE3B, CCL22, CCR4, CCL17, IL17D
5skin disease30.4PI3, FLG, DEFB4A, CCL27, CXCL10, CCL17
6asthma30.2CCL17, CXCL10, CD160, IL17F, DEFB4A, FLG
7melanoma30.2CCR4, CXCL10, IL31, CCR10, CCL21
8allergic asthma30.2CCL17, FLG, CCR4
9hepatitis30.0CCL27, CXCL10
10cutaneous t cell lymphoma30.0CXCL10, CCR10, CCL17, CCR4
11occupational dermatitis11.0
12irritant dermatitis11.0
13erythema multiforme10.7
14photoallergic dermatitis10.5
15alopecia10.4
16seborrheic infantile dermatitis10.4
17rosacea10.3
18cheilitis10.3
19lupus erythematosus10.3
20urticaria10.3
21eczema herpeticum10.3
22paronychia10.2
23lichen planus10.2
24alopecia areata10.2
25otitis externa10.2
26allergic contact dermatitis of eyelid10.2
27spongiotic dermatitis10.2
28pemphigus10.2
29allergic urticaria10.2
30lichen nitidus10.2
31toxicodendron dermatitis10.2
32granuloma annulare10.2
33angioedema10.2
34conjunctivitis10.2
35exanthem10.2
36scabies10.2
37dyshidrosis10.1
38erythroderma lethal congenital10.1
39exfoliative dermatitis10.1
40prurigo nodularis10.1
41infective dermatitis associated with htlv-110.1
42erythroderma desquamativum10.1
43burns10.0
44wrinkles10.0
45diaper rash10.0
46melkersson-rosenthal syndrome10.0
47autoimmune thyroiditis10.0
48telogen effluvium10.0
49pityriasis rosea10.0
50multiple chemical sensitivity10.0

Graphical network of the top 20 diseases related to Contact Dermatitis:



Diseases related to contact dermatitis

Clinical Features for Contact Dermatitis

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Drugs & Therapeutics for Contact Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Contact Dermatitis

Drug clinical trials:

Search ClinicalTrials for Contact Dermatitis

Search NIH Clinical Center for Contact Dermatitis

Search CenterWatch for Contact Dermatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Contact Dermatitis

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Anatomical Context for Contact Dermatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Contact Dermatitis:

32
Skin, Testes, T cells, Eye, Lung, Monocytes, Spinal cord, Endothelial, Tongue, B cells, Bone, Nk cells, Lymph node, Thyroid, Pituitary

Animal Models for Contact Dermatitis or affiliated genes

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Publications for Contact Dermatitis

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Sources:
50PubMed
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Articles related to Contact Dermatitis:

(show top 50)    (show all 916)
idTitleAuthorsYear
1
Contact dermatitis caused by fatty alcohols: may polyethoxylation of the fatty alcohols influence their sensitizing potential? (23421464)
2013
2
Allergic contact dermatitis to methylisothiazolinone: exposure from baby wipes causing hand dermatitis. (23713837)
2013
3
Patch test reactions associated with sunscreen products and the importance of testing to an expanded series: retrospective analysis of North American Contact Dermatitis Group data, 2001 to 2010. (23857015)
2013
4
Occupational airborne contact dermatitis by isothiazolinones contained in wall paint products. (23880613)
2013
5
Allergic contact dermatitis caused by Chinese herbal medicine, white mustard seed. (23039226)
2013
6
Nonoccupational allergic contact dermatitis from ranitidine. (23758089)
2013
7
Occupational airborne contact dermatitis from benzodiazepines and other drugs. (24289767)
2013
8
Patch Testing with Formaldehyde 2.0% in Parallel with 1.0% by the Swedish Contact Dermatitis Research Group. (24337098)
2013
9
Allergic contact dermatitis to benzocaine: the importance of concomitant positive patch test results. (22551703)
2013
10
Your're the flight surgeon: contact dermatitis. (23745300)
2013
11
Contact dermatitis to para-phenylenediamine in hair dye following sensitization to black henna tattoos - an ongoing problem. (22299643)
2012
12
Systemic allergic contact dermatitis to palladium inlay manifesting as annular erythema. (22759481)
2012
13
Occupational protein contact dermatitis from wheat flour with IgE reactivity against I+-amylase inhibitor. (23039009)
2012
14
Allergic contact dermatitis: xenoinflammation of the skin. (22980498)
2012
15
Allergic contact dermatitis to p-tert butylphenol formaldehyde resin in a continuous positive airway pressure strap. (22653174)
2012
16
Airborne allergic contact dermatitis from tylosin in pharmacy compounders and cross-sensitization to macrolide antibiotics. (23010831)
2012
17
Erythema multiforme-like lesions revealing allergic contact dermatitis to exotic woods. (22149465)
2012
18
Abnormal epidermal barrier in the pathogenesis of contact dermatitis. (22507049)
2012
19
Clinical Features of Systemic Contact Dermatitis Due to the Ingestion of Lacquer in the Province of Chungcheongnam-do. (22879716)
2012
20
Connubial allergic contact dermatitis caused by fragrance ingredients. (22653075)
2012
21
Dental allergic contact dermatitis: an interesting case series and review of the literature. (23010830)
2012
22
Prevention of airborne propolis-induced allergic contact dermatitis with barrier cream. (22653177)
2012
23
Efficacy of new barrier socks in the treatment of foot allergic contact dermatitis. (21031284)
2011
24
Recurrent infections in children with nickel allergic contact dermatitis. (22217998)
2011
25
Disease severity and quality of life in a follow-up study of patients with occupational contact dermatitis. (21722138)
2011
26
Nonpruritic contact dermatitis from disperse blue dyes. (22652906)
2011
27
Allergic contact dermatitis to preservatives and fragrances in cosmetics. (21611680)
2011
28
Concurrent allergic contact dermatitis of the index fingers and lips from toothpaste: report of three cases. (22202513)
2011
29
Allergic contact dermatitis caused by TinosorbAr M. (21658058)
2011
30
Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B. (20601178)
2010
31
Occupational allergic contact dermatitis to olanzapine. (20136900)
2010
32
Tacrolimus modulates dendritic cell activation in the sensitization phase of allergic contact dermatitis. (20090409)
2010
33
Allergic contact dermatitis to inhalation corticosteroids. (19825528)
2010
34
Allergic contact dermatitis from a permanent marker. (20137742)
2010
35
Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream. (20546226)
2010
36
Allergic contact dermatitis in children: common allergens and treatment: a review. (19584724)
2009
37
Allergic contact dermatitis to hearing aids: literature and case reports. (19397624)
2009
38
Three cases of allergic contact dermatitis to 4,4'-diaminodiphenylmethane. (19489974)
2009
39
Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis. (18416756)
2008
40
A correlation of allergic contact dermatitis with allergen type and patient categorical variables. (19037759)
2008
41
A case of allergic contact dermatitis to clavulanic acid. (19076895)
2008
42
Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis. (18056398)
2007
43
A farmer's occupational airborne contact dermatitis masqueraded by coexisting rosacea: delayed diagnosis and legal acknowledgement. (15627345)
2004
44
Cytokine gene polymorphisms in allergic contact dermatitis. (12694213)
2003
45
Reduced levels of glutathione S-transferases in patch test reactions to dithranol and sodium lauryl sulphate as demonstrated by quantitative immunocytochemistry: evidence for oxidative stress in acute irritant contact dermatitis. (11275802)
2001
46
Recurrent allergic contact dermatitis and cheilitis due to castor oil. (10703646)
2000
47
Sesquiterpene lactone mix contact sensitivity and its relationship to chronic actinic dermatitis: a follow-up study. (9771984)
1998
48
Keratinocyte expression of intercellular adhesion molecule 1 (ICAM-1) correlated with infiltration of lymphocyte function associated antigen 1 (LFA-1) positive cells in evolving allergic contact dermatitis reactions. (1682230)
1991
49
Contact allergic and primary irritant dermatitis in industry vs. what else? (4274012)
1974
50
Generalized exfoliative dermatitis due to contact with an antiperspirant. (4282025)
1974

Genetic Variations for Contact Dermatitis

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Expression for genes affiliated with Contact Dermatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Contact Dermatitis

Search GEO for disease gene expression data for Contact Dermatitis.

Pathways for genes affiliated with Contact Dermatitis

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Contact Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CCL27, CCL17, CCL21, CCL19, CCL22
2
Hide members
10.4CCL22, CXCL10, CCL27, CCL17, CCL21, CCL19
3
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10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
4
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10.4CCL27, CCL17, CCL21, CCL19, CCR4, CCL22
5
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
610.4CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
7
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
8
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
9
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
10
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27

Compounds for genes affiliated with Contact Dermatitis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Contact Dermatitis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1rantes4410.8DEFB4A
2tarc4410.7CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
3larc4410.7CCL22, CCR4, CCL19, CCL21, CCL17
4ccl344 2811.7CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
5ccl444 2811.7CCL22, CCR4, CCL21, CCL17, CCL27, CXCL10
6histamine44 28 2412.7CCL22, PI3, DEFB4A, CD160, CXCL10, IL31
7teck4410.7CCR4, CCL19, CCL21
8allergens4410.7CXCL10, FLG, CCL27, CCL17
9mip-3beta4410.7CCL19, CCL21
10dexamethasone44 49 28 1113.6CCL22, CCL17, CCL27, PI3, DEFB4A, CXCL10
11calcium44 49 11 2413.6CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
12dithranol4410.6FLG, PI3
13pge24410.6CCL22, CCL19, CCL21, CCL27, CXCL10
14retinoic acid44 2411.6CCR4, PI3, FLG, DEFB4A, CXCL10, ADH5
15hbd24410.5DEFB4A, PI3
16[alcl]4410.5CCL17, CCR4
17lipid4410.4CCR4, CCL27, PI3, FLG, DEFB4A, CXCL10
18cyclosporin a44 28 5912.3CCL22, CCL17, PI3, CD160
19nitric oxide44 11 2412.2ADH5, CXCL10, FLG, PI3, CCL17

GO Terms for genes affiliated with Contact Dermatitis

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Sources:
16Gene Ontology
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Cellular components related to Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4CCL19, CCL21, CCL17, CCL27, DEFB4A, CXCL10
2extracellular spaceGO:00561510.1VNN3, CCL22, CCL19, CCL21, CCL17, CCL27

Biological processes related to Contact Dermatitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.7CCL22, CCR4, CCL17, CCL27, CCR10, DEFB4A
2positive regulation of glycoprotein biosynthetic processGO:01056010.7CCL21, CCL19
3cell-cell signalingGO:00726710.7CCL22, CCL21, CCL17, CCL27, CXCL10
4immunological synapse formationGO:00177110.7CCL21, CCL19
5immune responseGO:00695510.7CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
6inflammatory responseGO:00695410.7CCL22, CCR4, CCL19, CCL21, CCL17, CXCL10
7negative regulation of leukocyte apoptotic processGO:200010710.7CCL19, CCL21
8establishment of T cell polarityGO:00176810.7CCL19, CCL21
9response to prostaglandin E stimulusGO:03469510.6CCL21, CCL19
10positive regulation of dendritic cell antigen processing and presentationGO:00260610.6CCL21, CCL19
11positive regulation of cell motilityGO:200014710.6CCL19, CCL21
12positive regulation of chemotaxisGO:05092110.6CCL19, CCL21
13positive regulation of receptor-mediated endocytosisGO:04826010.5CCL21, CCL19
14dendritic cell chemotaxisGO:00240710.4CCL21, CCL19
15release of sequestered calcium ion into cytosolGO:05120910.4CCL21, CCL19
16positive regulation of neutrophil chemotaxisGO:09002310.3CCL19, CCL21
17positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.1CCL21, CCL19

Molecular functions related to Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.4CCR10, CCR4
2chemokine activityGO:00800910.3CXCL10, CCL22, CCL19, CCL21, CCL17, CCL27
3CCR7 chemokine receptor bindingGO:03173210.1CCL21, CCL19

Products for genes affiliated with Contact Dermatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Contact Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet