MCID: CNT047
MIFTS: 59

Contact Dermatitis malady

Skin diseases category

Summaries for Contact Dermatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Contact dermatitis is a type of skin inflammation (dermatitis) that results from exposure to allergens... more...

MalaCards: Contact Dermatitis, also known as contact dermatitis/eczema, is related to dermatitis and allergic contact dermatitis. An important gene associated with Contact Dermatitis is ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide), and among its related pathways are TGF-Beta Pathway and PAK Pathway. The drugs pramoxine and pramoxine hydrochloride and the compounds rantes and tarc have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells.

Aliases & Classifications for Contact Dermatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Contact Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Contact Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis32.2CCL27, CCL17, CCR4, CCL22, CCR10, FLG
2allergic contact dermatitis32.1CXCL10, FLG, CCL27, CCR4
3atopic dermatitis31.0IL31, CXCL10, FLG, CCL17, CCR4, CCL22
4psoriasis30.8LCE3C, LCE3B, CCL22, CCR4, CCL17, IL17D
5skin disease30.4PI3, FLG, DEFB4A, CCL27, CXCL10, CCL17
6asthma30.2CCL17, CXCL10, CD160, IL17F, DEFB4A, FLG
7melanoma30.2CCR4, CXCL10, IL31, CCR10, CCL21
8allergic asthma30.2CCL17, FLG, CCR4
9hepatitis30.0CCL27, CXCL10
10cutaneous t cell lymphoma30.0CXCL10, CCR10, CCL17, CCR4
11occupational dermatitis11.0
12irritant dermatitis11.0
13erythema multiforme10.7
14photoallergic dermatitis10.5
15alopecia10.4
16seborrheic infantile dermatitis10.4
17rosacea10.3
18cheilitis10.3
19lupus erythematosus10.3
20urticaria10.3
21eczema herpeticum10.3
22paronychia10.2
23lichen planus10.2
24alopecia areata10.2
25otitis externa10.2
26allergic contact dermatitis of eyelid10.2
27spongiotic dermatitis10.2
28pemphigus10.2
29allergic urticaria10.2
30lichen nitidus10.2
31toxicodendron dermatitis10.2
32granuloma annulare10.2
33angioedema10.2
34conjunctivitis10.2
35exanthem10.2
36scabies10.2
37dyshidrosis10.1
38erythroderma lethal congenital10.1
39exfoliative dermatitis10.1
40prurigo nodularis10.1
41infective dermatitis associated with htlv-110.1
42erythroderma desquamativum10.1
43burns10.0
44wrinkles10.0
45diaper rash10.0
46melkersson-rosenthal syndrome10.0
47autoimmune thyroiditis10.0
48telogen effluvium10.0
49pityriasis rosea10.0
50multiple chemical sensitivity10.0

Graphical network of the top 20 diseases related to Contact Dermatitis:



Diseases related to contact dermatitis

Clinical Features for Contact Dermatitis

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Drugs & Therapeutics for Contact Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Contact Dermatitis

Drug clinical trials:

Search ClinicalTrials for Contact Dermatitis

Search NIH Clinical Center for Contact Dermatitis

Search CenterWatch for Contact Dermatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Contact Dermatitis

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Anatomical Context for Contact Dermatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Contact Dermatitis:

32
Skin, Testes, T cells, Eye, Lung, Monocytes, Spinal cord, Endothelial, Tongue, B cells, Bone, Nk cells, Lymph node, Thyroid, Pituitary

Animal Models for Contact Dermatitis or affiliated genes

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Publications for Contact Dermatitis

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Sources:
50PubMed
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Articles related to Contact Dermatitis:

(show top 50)    (show all 916)
idTitleAuthorsYear
1
Hard metal lung disease diagnosed on a transbronchial lung biopsy following recurrent contact dermatitis. (24429455)
2014
2
Irritant Contact Dermatitis due to "Kajal". (23681832)
2014
3
Chlorhexidine gluconatea89impregnated central access catheter dressings as a cause of erosive contact dermatitis: a report of 7 cases. (23560299)
2013
4
Budesonide allergic contact dermatitis "by proxy"? (23665829)
2013
5
Occupational and non-occupational allergic contact dermatitis and quality of life: a prospective study. (24068152)
2013
6
Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis by regulating the balance between inflammatory and anti-inflammatory cytokines. (24096935)
2013
7
Postsurgical Contact Dermatitis due to Povidone Iodine: A Diagnostic Dilemma. (23375149)
2013
8
Allergic contact dermatitis caused by a nursing comfort balm: methyl glucose dioleate as the sensitizing ingredient. (23601067)
2013
9
An update on airborne contact dermatitis: 2007-2011. (23343440)
2013
10
Allergic contact dermatitis to colophonium in a sanitary pad-an overlooked allergen? (22320672)
2012
11
Contact dermatitis: from pathomechanisms to immunotoxicology. (22509837)
2012
12
Urushiol-induced contact dermatitis caused during Shodhana (purificatory measures) of Bhallataka (Semecarpus anacardium Linn.) fruit. (23559802)
2012
13
Allergic contact dermatitis caused by C30-38 olefin/isopropyl maleate/MA copolymer in cosmetics. (23039010)
2012
14
Tomato contact dermatitis. (22860619)
2012
15
Allergic contact dermatitis among construction workers detected in a clinic that did not specialize in occupational dermatitis. (22892770)
2012
16
Allergic contact dermatitis induced by topical hydrocortisone-17-butyrate mimicking papular rosacea. (22653130)
2012
17
Participation of complement 3a receptor (C3aR) in the sensitization phase of Th2 mediated allergic contact dermatitis. (22151392)
2012
18
Allergic contact dermatitis caused by benzophenone-4 in a printer. (21272034)
2011
19
Dipeptidyl peptidase IV (DPP4) deficiency increases Th1-driven allergic contact dermatitis. (21672052)
2011
20
Occupational contact dermatitis in manual cloud seeding operations. (21633757)
2011
21
Allergic contact dermatitis in private practice: what are the main sensitizers? (21781641)
2011
22
Number of flocks on the same litter and carcase condemnations due to cellulitis, arthritis and contact foot-pad dermatitis in broilers. (21058060)
2010
23
Extensive keloids over lesions of air-borne contact dermatitis: an unusual manifestation. (20445307)
2010
24
Allergic contact dermatitis caused by p-tert-butylphenol formaldehyde resin and colophonium in neoprene thermal sauna shorts. (20831691)
2010
25
Allergic contact dermatitis associated with the use of facemask on a patient with a history of atopy. (22044472)
2010
26
Filaggrin null mutations and association with contact allergy and allergic contact dermatitis: results from a tertiary dermatology clinic. (20629673)
2010
27
Milia after allergic contact dermatitis from poison ivy: two cases. (20487653)
2010
28
Allergic contact dermatitis due to a PVC table cover. (20844058)
2010
29
Occupational airborne allergic contact dermatitis from potassium metabisulfite. (19125722)
2009
30
Occupational allergic contact dermatitis from cinnamon including one case from airborne exposure. (19207380)
2009
31
Gender differences in topical treatment of allergic contact dermatitis. (19197547)
2009
32
Allergic contact dermatitis to polyethylene terephthalate mesh. (19476023)
2009
33
Occupational allergic contact dermatitis among construction workers in India. (20101309)
2009
34
Triclosan: a potential allergen in suture-line allergic contact dermatitis. (19389086)
2009
35
Postelicitation model of allergic contact dermatitis for predicting the efficacy of topical drugs. (19054064)
2009
36
Allergic contact dermatitis to phytantriol. (18844705)
2008
37
Safety of blocking vascular adhesion protein-1 in patients with contact dermatitis. (15910406)
2005
38
Allergic contact dermatitis from a topical corticosteroid mimicking acute generalized exanthematous pustulosis. (16159739)
2005
39
Eyelid discoid lupus erythematosus and contact dermatitis: a case report. (15324398)
2004
40
Afferent and efferent phases of allergic contact dermatitis (ACD) can be induced after a single skin contact with haptens: evidence using a mouse model of primary ACD. (12648229)
2003
41
Contact irritant dermatitis and anti-pruritic agents: the need to address the itch. (12852365)
2003
42
Occupational dermatitis in dental personnel: contact dermatitis with special reference to (meth)acrylates in 174 patients. (11553142)
2001
43
Erythema multiforme-like eruption associated with contact dermatitis to cutting oil. (11358734)
2001
44
Erythema-multiforme-like eruption and depigmentation following allergic contact dermatitis from a paint-on henna tattoo, due to para-phenylenediamine contact hypersensitivity. (11683847)
2001
45
An immunohistochemical analysis of cytokine expression in allergic and irritant contact dermatitis. (10954204)
2000
46
Keratin 17 is expressed during the course of SLS-induced irritant contact dermatitis, but unlike keratin 16, the degree of expression is unrelated to the density of dividing keratinocytes. (9686973)
1998
47
Cytokines and irritant contact dermatitis. (10022266)
1998
48
Effect of N-acetylcysteine, an inhibitor of tumor necrosis factor, on irritant contact dermatitis in the human. (9035915)
1995
49
Neuropeptides enhance irritant and allergic contact dermatitis. (1708795)
1991
50
Irritant dermatitis from tri-butyl tin oxide and contact allergy from chlorocresol. (2960483)
1987

Genetic Variations for Contact Dermatitis

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Expression for genes affiliated with Contact Dermatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Contact Dermatitis

Search GEO for disease gene expression data for Contact Dermatitis.

Pathways for genes affiliated with Contact Dermatitis

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Sources:
51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Contact Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CCL19, CCL27, CCL21, CCL22, CCL17
2
Hide members
10.4CCL17, CCL27, CXCL10, CCL19, CCR4, CCL22
3
Hide members
10.4CCL19, CCL22, CXCL10, CCL27, CCL17, CCL21
4
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10.4CCL17, CCL22, CCR4, CCL19, CCL21, CCL27
5
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10.4CXCL10, CCL22, CCR4, CCL21, CCL17, CCL27
6
Hide members
10.4CXCL10, CCL22, CCL19, CCR4, CCL21, CCL17
7
Hide members
10.4CCR10, CCL22, CCR4, CCL19, CCL21, CCL17
810.4CCR4, CCL22, CXCL10, CCR10, CCL27, CCL17
9
Hide members
10.4CCL19, CCL17, CCL22, CXCL10, CCR10, CCR4
10
Hide members
10.4CCL22, CCR4, CCL19, CCL17, CCL27, CCR10

Compounds for genes affiliated with Contact Dermatitis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Contact Dermatitis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1rantes4410.8DEFB4A
2tarc4410.7CCL22, CCL17, CCL21, CCL19, CCR4, CCL27
3larc4410.7CCR4, CCL19, CCL21, CCL17, CCL22
4ccl344 2811.7CCL21, CCR4, CCL17, CCL27, CXCL10, CCL19
5ccl444 2811.7CCL27, CXCL10, CCL17, CCL21, CCL22, CCR4
6histamine44 28 2412.7CCL22, IL31, PI3, DEFB4A, CD160, CXCL10
7teck4410.7CCR4, CCL19, CCL21
8allergens4410.7CCL27, FLG, CCL17, CXCL10
9mip-3beta4410.7CCL21, CCL19
10dexamethasone44 49 28 1113.6CCL17, CXCL10, DEFB4A, PI3, CCL27, CCL22
11calcium44 49 11 2413.6CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
12dithranol4410.6FLG, PI3
13pge24410.6CCL19, CCL21, CCL27, CXCL10, CCL22
14retinoic acid44 2411.6CXCL10, DEFB4A, FLG, CCR4, ADH5, PI3
15hbd24410.5PI3, DEFB4A
16[alcl]4410.5CCL17, CCR4
17lipid4410.4DEFB4A, FLG, PI3, CCL27, CCR4, CXCL10
18cyclosporin a44 28 5912.3CCL22, CCL17, PI3, CD160
19nitric oxide44 11 2412.2CCL17, PI3, FLG, CXCL10, ADH5

GO Terms for genes affiliated with Contact Dermatitis

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Sources:
16Gene Ontology
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Cellular components related to Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4CCL22, CCL19, CCL21, CCL17, CCL27, DEFB4A
2extracellular spaceGO:00561510.1CCL22, CCL19, CCL21, CCL17, CCL27, CXCL10

Biological processes related to Contact Dermatitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.7CCL22, CCR4, CCL17, CCL27, CCR10, DEFB4A
2positive regulation of glycoprotein biosynthetic processGO:01056010.7CCL19, CCL21
3cell-cell signalingGO:00726710.7CCL27, CXCL10, CCL21, CCL22, CCL17
4immunological synapse formationGO:00177110.7CCL19, CCL21
5immune responseGO:00695510.7CXCL10, CCL17, DEFB4A, CCR10, CCL27, CCL21
6inflammatory responseGO:00695410.7CCL22, CCL19, CCL21, CCL17, CXCL10, IL17D
7negative regulation of leukocyte apoptotic processGO:200010710.7CCL21, CCL19
8establishment of T cell polarityGO:00176810.7CCL21, CCL19
9response to prostaglandin E stimulusGO:03469510.6CCL21, CCL19
10positive regulation of dendritic cell antigen processing and presentationGO:00260610.6CCL21, CCL19
11positive regulation of cell motilityGO:200014710.6CCL21, CCL19
12positive regulation of chemotaxisGO:05092110.6CCL19, CCL21
13positive regulation of receptor-mediated endocytosisGO:04826010.5CCL19, CCL21
14dendritic cell chemotaxisGO:00240710.4CCL19, CCL21
15release of sequestered calcium ion into cytosolGO:05120910.4CCL21, CCL19
16positive regulation of neutrophil chemotaxisGO:09002310.3CCL19, CCL21
17positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.1CCL19, CCL21

Molecular functions related to Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.4CCR10, CCR4
2chemokine activityGO:00800910.3CXCL10, CCL22, CCL19, CCL21, CCL17, CCL27
3CCR7 chemokine receptor bindingGO:03173210.1CCL21, CCL19

Products for genes affiliated with Contact Dermatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Contact Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet