MCID: CNT047
MIFTS: 59

Contact Dermatitis malady

Skin diseases category

Summaries for Contact Dermatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Contact dermatitis is a type of skin inflammation (dermatitis) that results from exposure to allergens... more...

MalaCards: Contact Dermatitis, also known as contact dermatitis/eczema, is related to dermatitis and allergic contact dermatitis. An important gene associated with Contact Dermatitis is ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide), and among its related pathways are TGF-Beta Pathway and PAK Pathway. The drugs pramoxine and pramoxine hydrochloride and the compounds rantes and tarc have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells.

Aliases & Classifications for Contact Dermatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Contact Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Contact Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis32.2CCL27, CCL17, CCR4, CCL22, CCR10, FLG
2allergic contact dermatitis32.1CXCL10, FLG, CCL27, CCR4
3atopic dermatitis31.0IL31, CXCL10, FLG, CCL17, CCR4, CCL22
4psoriasis30.8LCE3C, LCE3B, CCL22, CCR4, CCL17, IL17D
5skin disease30.4PI3, FLG, DEFB4A, CCL27, CXCL10, CCL17
6asthma30.2CCL17, CXCL10, CD160, IL17F, DEFB4A, FLG
7melanoma30.2CCR4, CXCL10, IL31, CCR10, CCL21
8allergic asthma30.2CCL17, FLG, CCR4
9hepatitis30.0CCL27, CXCL10
10cutaneous t cell lymphoma30.0CXCL10, CCR10, CCL17, CCR4
11occupational dermatitis11.0
12irritant dermatitis11.0
13erythema multiforme10.7
14photoallergic dermatitis10.5
15alopecia10.4
16seborrheic infantile dermatitis10.4
17rosacea10.3
18cheilitis10.3
19lupus erythematosus10.3
20urticaria10.3
21eczema herpeticum10.3
22paronychia10.2
23lichen planus10.2
24alopecia areata10.2
25otitis externa10.2
26allergic contact dermatitis of eyelid10.2
27spongiotic dermatitis10.2
28pemphigus10.2
29allergic urticaria10.2
30lichen nitidus10.2
31toxicodendron dermatitis10.2
32granuloma annulare10.2
33angioedema10.2
34conjunctivitis10.2
35exanthem10.2
36scabies10.2
37dyshidrosis10.1
38erythroderma lethal congenital10.1
39exfoliative dermatitis10.1
40prurigo nodularis10.1
41infective dermatitis associated with htlv-110.1
42erythroderma desquamativum10.1
43burns10.0
44wrinkles10.0
45diaper rash10.0
46melkersson-rosenthal syndrome10.0
47autoimmune thyroiditis10.0
48telogen effluvium10.0
49pityriasis rosea10.0
50multiple chemical sensitivity10.0

Graphical network of the top 20 diseases related to Contact Dermatitis:



Diseases related to contact dermatitis

Clinical Features for Contact Dermatitis

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Drugs & Therapeutics for Contact Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Contact Dermatitis

Drug clinical trials:

Search ClinicalTrials for Contact Dermatitis

Search NIH Clinical Center for Contact Dermatitis

Search CenterWatch for Contact Dermatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Contact Dermatitis

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Anatomical Context for Contact Dermatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Contact Dermatitis:

32
Skin, Testes, T cells, Eye, Lung, Monocytes, Spinal cord, Endothelial, Tongue, B cells, Bone, Nk cells, Lymph node, Thyroid, Pituitary

Animal Models for Contact Dermatitis or affiliated genes

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Publications for Contact Dermatitis

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Sources:
50PubMed
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Articles related to Contact Dermatitis:

(show top 50)    (show all 916)
idTitleAuthorsYear
1
Allergic contact dermatitis to lyofoam polyurethane dressing used as padding by a patient with above-knee amputation. (24407068)
2014
2
Facial contact dermatitis and the irritant potential of mobile phone screens. (23025548)
2013
3
Contact dermatitis: facts and controversies. (23806164)
2013
4
Allergic contact dermatitis caused by menthoxypropanediol in a lip cosmetic. (24215526)
2013
5
Allergic contact dermatitis beyond IL-1I^-role of additional family members. (24372765)
2013
6
Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis. (22931926)
2013
7
Perphenazine as a cause of mother-to-daughter contact dermatitis and photocontact dermatitis. (23653979)
2013
8
Allergic contact dermatitis caused by topical 2-octyl-cyanoacrylate. (23601068)
2013
9
Irritant contact dermatitis to accidental exposure of cyanide. (23716845)
2013
10
Shock treatment: swimming pool contact dermatitis. (23131107)
2013
11
Protein contact dermatitis--case report. (24068135)
2013
12
Contact dermatitis caused by ambulatory blood pressure monitoring. (23346009)
2013
13
Extract of Rhus verniciflua Bark Suppresses 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis. (23710240)
2013
14
Glutamine suppresses DNFB-induced contact dermatitis by deactivating p38 mitogen-activated protein kinase via induction of MAPK phosphatase-1. (23076500)
2013
15
Anti-inflammatory activities of Dictamnus dasycarpus Turcz., root bark on allergic contact dermatitis induced by dinitrofluorobenzene in mice. (23850712)
2013
16
Contact dermatitis from unexpected exposure to rosin from a toilet seat. (23665825)
2013
17
Allergic contact dermatitis caused by octocrylene in a young child. (22957488)
2012
18
Allergic contact dermatitis caused by polyester-8 (PolycryleneAr) in a sunscreen moisturizer. (22775545)
2012
19
Occupational contact dermatitis in painters: an analysis of patch test data from the Danish Contact Dermatitis Group. (22551399)
2012
20
Allergic contact cheilitis and perioral dermatitis caused by propolis: case report. (23069305)
2012
21
Occupational allergic contact dermatitis caused by (R)-3-(2-chloro-1-hydroxyethyl)-phenol. (23151194)
2012
22
Irritant contact dermatitis due to the use of a continuous positive airway pressure nasal mask: 2 case reports and review of the literature. (23094310)
2012
23
Systemic contact dermatitis to corticosteroids. (23033862)
2012
24
Quantitative assessment of diethylthiourea exposure in two cases of occupational allergic contact dermatitis. (21210829)
2011
25
Allergic contact dermatitis caused by iodophor-impregnated surgical incise drape. (21985088)
2011
26
Systemic (allergic) contact dermatitis to diclofenac. (21727717)
2011
27
Contact dermatitis in military personnel. (22653003)
2011
28
Airborne contact dermatitis to triclosan. (21906072)
2011
29
Amelanotic melanoma presenting as contact dermatitis. (20956099)
2010
30
Peristomal allergic contact dermatitis to stoma-adhesive paste containing monobutyl ester/maleic acid of polymethylvinylether (Gantrez 425) but not to Isopropyl ester/maleic anhydride of polymethylvinylether (Gantrez 335). (20136898)
2010
31
A comparative study of allergic contact dermatitis by patch test versus reflectance confocal laser microscopy, with nickel and cobalt. (20822971)
2010
32
Allergic contact dermatitis from aluminium in deodorants. (20136883)
2010
33
Allergic contact dermatitis to dimethyl fumarate in footwear. (20136899)
2010
34
Occupational allergic contact dermatitis and asthma due to a single low molecular weight agent. (19057115)
2009
35
Patch tests in children with suspected allergic contact dermatitis: a prospective study and review of the literature. (18946202)
2009
36
Allergic contact dermatitis to 1,2-benzisothiazolin-3-one in the water softener manufacturing industry. (19780781)
2009
37
Rapid development of allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate. (19804698)
2009
38
Nail dystrophy and fingertip dermatitis as a manifestation of methyl methacrylate allergic contact dermatitis in a cow hoof trimmer. (19489971)
2009
39
Airborne allergic contact dermatitis due to budesonide from professional exposure. (18976387)
2008
40
Occupational allergic contact dermatitis from epoxy resin in a golf club repairman. (18845108)
2008
41
Erythema multiforme-like eruption induced by contact dermatitis caused by topical corticosteroids. (18833067)
2008
42
Contact sensitizations in metalworkers with occupational dermatitis exposed to water-based metalworking fluids: results of the research project "FaSt". (15538620)
2004
43
Early inflammatory markers in elicitation of allergic contact dermatitis. (12167174)
2002
44
Contact dermatitis associated with an erythema multiforme-like eruption. (11187214)
2000
45
Cheilitis: analysis of 75 cases referred to a contact dermatitis clinic. (10594294)
1999
46
Interleukin-4 and the interleukin-4 receptor in allergic contact dermatitis. (9504244)
1998
47
Immunohistochemical characterization of HSP, alpha-MSH, Merkel cells and neuronal markers in acute UV dermatitis and acute contact dermatitis in vivo. (9372313)
1997
48
Allergic contact dermatitis prevalence in patients with otitis externa. (1675529)
1991
49
Androgenetic alopecia--is contact dermatitis an accelerating factor? (2323197)
1990
50
Exfoliative dermatitis from contact with DDT. (18120699)
1949

Genetic Variations for Contact Dermatitis

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Expression for genes affiliated with Contact Dermatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Contact Dermatitis

Search GEO for disease gene expression data for Contact Dermatitis.

Pathways for genes affiliated with Contact Dermatitis

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Contact Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CCL27, CCL17, CCL21, CCL19, CCL22
2
Hide members
10.4CCL22, CXCL10, CCL27, CCL17, CCL21, CCL19
3
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
4
Hide members
10.4CCL27, CCL17, CCL21, CCL19, CCR4, CCL22
5
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
610.4CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
7
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
8
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
9
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
10
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27

Compounds for genes affiliated with Contact Dermatitis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Contact Dermatitis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1rantes4410.8DEFB4A
2tarc4410.7CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
3larc4410.7CCL22, CCR4, CCL19, CCL21, CCL17
4ccl344 2811.7CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
5ccl444 2811.7CCL22, CCR4, CCL21, CCL17, CCL27, CXCL10
6histamine44 28 2412.7CCL22, PI3, DEFB4A, CD160, CXCL10, IL31
7teck4410.7CCR4, CCL19, CCL21
8allergens4410.7CXCL10, FLG, CCL27, CCL17
9mip-3beta4410.7CCL19, CCL21
10dexamethasone44 49 28 1113.6CCL22, CCL17, CCL27, PI3, DEFB4A, CXCL10
11calcium44 49 11 2413.6CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
12dithranol4410.6FLG, PI3
13pge24410.6CCL22, CCL19, CCL21, CCL27, CXCL10
14retinoic acid44 2411.6CCR4, PI3, FLG, DEFB4A, CXCL10, ADH5
15hbd24410.5DEFB4A, PI3
16[alcl]4410.5CCL17, CCR4
17lipid4410.4CCR4, CCL27, PI3, FLG, DEFB4A, CXCL10
18cyclosporin a44 28 5912.3CCL22, CCL17, PI3, CD160
19nitric oxide44 11 2412.2ADH5, CXCL10, FLG, PI3, CCL17

GO Terms for genes affiliated with Contact Dermatitis

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Sources:
16Gene Ontology
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Cellular components related to Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4CCL19, CCL21, CCL17, CCL27, DEFB4A, CXCL10
2extracellular spaceGO:00561510.1VNN3, CCL22, CCL19, CCL21, CCL17, CCL27

Biological processes related to Contact Dermatitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.7CCL22, CCR4, CCL17, CCL27, CCR10, DEFB4A
2positive regulation of glycoprotein biosynthetic processGO:01056010.7CCL21, CCL19
3cell-cell signalingGO:00726710.7CCL22, CCL21, CCL17, CCL27, CXCL10
4immunological synapse formationGO:00177110.7CCL21, CCL19
5immune responseGO:00695510.7CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
6inflammatory responseGO:00695410.7CCL22, CCR4, CCL19, CCL21, CCL17, CXCL10
7negative regulation of leukocyte apoptotic processGO:200010710.7CCL19, CCL21
8establishment of T cell polarityGO:00176810.7CCL19, CCL21
9response to prostaglandin E stimulusGO:03469510.6CCL21, CCL19
10positive regulation of dendritic cell antigen processing and presentationGO:00260610.6CCL21, CCL19
11positive regulation of cell motilityGO:200014710.6CCL19, CCL21
12positive regulation of chemotaxisGO:05092110.6CCL19, CCL21
13positive regulation of receptor-mediated endocytosisGO:04826010.5CCL21, CCL19
14dendritic cell chemotaxisGO:00240710.4CCL21, CCL19
15release of sequestered calcium ion into cytosolGO:05120910.4CCL21, CCL19
16positive regulation of neutrophil chemotaxisGO:09002310.3CCL19, CCL21
17positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.1CCL21, CCL19

Molecular functions related to Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.4CCR10, CCR4
2chemokine activityGO:00800910.3CXCL10, CCL22, CCL19, CCL21, CCL17, CCL27
3CCR7 chemokine receptor bindingGO:03173210.1CCL21, CCL19

Products for genes affiliated with Contact Dermatitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Contact Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet