MCID: CNT047
MIFTS: 49

Contact Dermatitis malady

Skin category

Summaries for Contact Dermatitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Contact dermatitis is a type of skin inflammation (dermatitis) that results from exposure to allergens... more...

MalaCards: Contact Dermatitis, also known as contact dermatitis/eczema, is related to allergic contact dermatitis and atopic dermatitis. An important gene associated with Contact Dermatitis is ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide), and among its related pathways are TGF-Beta Pathway and PAK Pathway. The drugs pramoxine and pramoxine hydrochloride and the compounds rantes and tarc have been mentioned in the context of this disorder.

Aliases & Classifications for Contact Dermatitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Related Diseases for Contact Dermatitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Contact Dermatitis:



Diseases related to contact dermatitis

Clinical Features for Contact Dermatitis

Drugs & Therapeutics for Contact Dermatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Contact Dermatitis

Drug clinical trials:

Search ClinicalTrials for Contact Dermatitis

Search NIH Clinical Center for Contact Dermatitis

Search CenterWatch for Contact Dermatitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Contact Dermatitis

Anatomical Context for Contact Dermatitis

Animal Models for Contact Dermatitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Contact Dermatitis

Sources:
51PubMed
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Articles related to Contact Dermatitis:

(show top 50)    (show all 916)
idTitleAuthorsYear
1
A survey of exposures related to recognized occupational contact dermatitis in Denmark in 2010. (24102286)
2014
2
Article removed: Severe contact dermatitis due to camomile: a common complementary remedy with potential sensitization risks. (23855780)
2013
3
Allergic contact dermatitis due to dazomet absorbed by agricultural rubber boots. (22334325)
2013
4
Allergic contact dermatitis: is the reactive chemistry of skin sensitizers the whole story? A response. (23510346)
2013
5
Contact dermatitis due to methyl methacrylate: uncommon and unwanted entity for dentists. (24347449)
2013
6
Serum resistin in patients with allergic contact dermatitis. (23857014)
2013
7
Allergic contact dermatitis to fragrances: part 2. (22770503)
2013
8
Surgery for a tree surgeon? Acute presentation of contact dermatitis due to Ailanthus altissima. (23273642)
2013
9
Allergic contact dermatitis due to sensitisation to sunscreen in two infants. (23287584)
2013
10
Archer dermatitis: a new case of allergic contact dermatitis. (23873984)
2013
11
Allergic contact dermatitis caused by phenylethyl resorcinol [4-(1-phenylethyl)-1,3-benzenediol], a skin-lightening agent in cosmetics. (24117746)
2013
12
Allergic contact dermatitis in children: which factors are relevant? (review of the literature). (23373713)
2013
13
Contact dermatitis caused by lovage (Levisticum officinalis) essential oil. (23948036)
2013
14
Acute irritant threshold correlates with barrier function, skin hydration and contact hypersensitivity in atopic dermatitis and rosacea. (24112695)
2013
15
Sesquiterpene lactone-related allergic contact dermatitis after exposure to tulip poplar wood and bark. (22653126)
2012
16
Undisclosed methyldibromo glutaronitrile causing allergic contact dermatitis in a NSAID cream. (22897782)
2012
17
Management of irritant contact dermatitis and peripherally inserted central catheters. (22459537)
2012
18
Current strategies in treating severe contact dermatitis in pediatric patients. (22993109)
2012
19
Occupational irritant contact dermatitis caused by Lobelia richardii in an Ethiopian flower farm. (22775548)
2012
20
Unusual localization of allergic contact dermatitis to p-phenylenediamine in a dye. (22481584)
2012
21
Allergic contact dermatitis following ocular use of corticosteroids. (21265627)
2011
22
Allergic contact dermatitis caused by bis-diglycerylpolyacyladipate-2 (SoftisanAr 649) owing to its 12-hydroxystearic acid content. (22077441)
2011
23
Allergic contact dermatitis caused by gum rosin and wood rosin in Tako-no-Suidashi ointment. (21592201)
2011
24
Allergic contact dermatitis caused by azithromycin in an eye drop. (21480922)
2011
25
A half of schoolchildren with 'ISAAC eczema' are ill with allergic contact dermatitis. (21134222)
2011
26
Use of frozen poloxamer as a base for Itchy skin conditions, including irritant contact dermatitis. (21781082)
2011
27
Erythema multiforme-like irritant contact dermatitis after application of an antiscabies treatment. (21658333)
2011
28
Allergic contact dermatitis to black henna. (21993708)
2011
29
Contact dermatitis with severe scalp swelling and upper airway compromise due to black henna hair dye. (21822086)
2011
30
Contact depigmentation following irritant contact dermatitis to chloroxylenol (Dettol). (21860168)
2011
31
Polyurethane toilet seat contact dermatitis. (21575050)
2011
32
A Summary of shoe allergic contact dermatitis caused by dimethyl fumarate in Spain. (21745221)
2011
33
Allergic contact dermatitis from formaldehyde textile resins. (20233544)
2010
34
Fiddler's Neck Accompanied by Allergic Contact Dermatitis to Nickel in a Viola Player. (20548892)
2010
35
Allergic contact dermatitis due to the beta-blocker betaxolol in eyedrops, with cross-sensitivity to timolol. (20536484)
2010
36
Patch testing in allergic contact dermatitis from minoxidil. (20646674)
2010
37
Pigmented contact dermatitis due to therapeutic sensitizer as complication of contact immunotherapy in alopecia areata. (20860739)
2010
38
Allergic Contact Dermatitis: Patch Testing Beyond the TRUE Test. (20967194)
2010
39
Interleukin-1 receptor antagonist and tumour necrosis factor-alpha gene polymorphisms in Turkish patients with allergic contact dermatitis. (19706048)
2009
40
Knowledge of Surgery-Related Allergic Contact Dermatitis among Florida Dermatological Surgeons: A Pilot Study. (20725578)
2009
41
Allergic contact dermatitis from heparin-containing gel: use of scratch patch test for diagnosis. (19470303)
2009
42
Mechanistic proposal for the formation of specific immunogenic complexes via a radical pathway: a key step in allergic contact dermatitis to olefinic hydroperoxides. (19725554)
2009
43
Allergic contact dermatitis from fragrance components in specific topical pharmaceutical products in Belgium. (19489964)
2009
44
Gene expression time course in the human skin during elicitation of allergic contact dermatitis. (17597826)
2007
45
Alteration of sensorineural circuits in spinal cord by chronic contact dermatitis. (16338820)
2005
46
Localized erythema multiforme-like contact dermatitis from laundry bar soap. (15725296)
2005
47
Lichen nitidus-like allergic contact dermatitis - a clinicopathological study. (14641122)
2003
48
Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells. (9764843)
1998
49
Leukaemia inhibitory factor: induction in the early phase of allergic contact dermatitis. (9034683)
1997
50
Triethanolamine-induced allergic contact dermatitis over a tuberculoid leprosy lesion. (2376685)
1990

Genetic Variations for Contact Dermatitis

Expression for genes affiliated with Contact Dermatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Contact Dermatitis

Search GEO for disease gene expression data for Contact Dermatitis.

Pathways for genes affiliated with Contact Dermatitis

Sources:
52QIAGEN, 54Reactome, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Contact Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CCL27, CCL17, CCL21, CCL19, CCL22
2
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10.4CCL22, CXCL10, CCL27, CCL17, CCL21, CCL19
3
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10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
4
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10.4CCL27, CCL17, CCL21, CCL19, CCR4, CCL22
5
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10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
610.4CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
7
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
8
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
9
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
10
Hide members
10.4CCL22, CCR4, CCL19, CCL21, CCL17, CCL27

Compounds for genes affiliated with Contact Dermatitis

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
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Compounds related to Contact Dermatitis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1rantes4510.8DEFB4A
2tarc4510.7CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
3larc4510.7CCL22, CCR4, CCL19, CCL21, CCL17
4ccl345 2911.7CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
5ccl445 2911.7CCL22, CCR4, CCL21, CCL17, CCL27, CXCL10
6histamine45 29 2412.7CCL22, PI3, DEFB4A, CD160, CXCL10, IL31
7teck4510.7CCR4, CCL19, CCL21
8allergens4510.7CXCL10, FLG, CCL27, CCL17
9mip-3beta4510.7CCL19, CCL21
10dexamethasone45 50 29 1113.6CCL22, CCL17, CCL27, PI3, DEFB4A, CXCL10
11calcium45 50 11 2413.6CCL22, CCR4, CCL19, CCL21, CCL17, CCL27
12dithranol4510.6FLG, PI3
13pge24510.6CCL22, CCL19, CCL21, CCL27, CXCL10
14retinoic acid45 2411.6CCR4, PI3, FLG, DEFB4A, CXCL10, ADH5
15hbd24510.5DEFB4A, PI3
16[alcl]4510.5CCL17, CCR4
17lipid4510.4CCR4, CCL27, PI3, FLG, DEFB4A, CXCL10
18cyclosporin a45 29 6012.3CCL22, CCL17, PI3, CD160
19nitric oxide45 11 2412.2ADH5, CXCL10, FLG, PI3, CCL17

GO Terms for genes affiliated with Contact Dermatitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4CCL22, CCL19, CCL21, CCL17, CCL27, DEFB4A
2extracellular spaceGO:00561510.1CCL22, CCL19, CCL21, CCL17, CCL27, CXCL10

Biological processes related to Contact Dermatitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.7CCL22, CCR4, CCL17, CCL27, CCR10, DEFB4A
2positive regulation of glycoprotein biosynthetic processGO:01056010.7CCL21, CCL19
3cell-cell signalingGO:00726710.7CCL22, CCL21, CCL17, CCL27, CXCL10
4immunological synapse formationGO:00177110.7CCL21, CCL19
5immune responseGO:00695510.7CXCL10, CCL22, CCR4, CCL19, CCL21, CCL17
6inflammatory responseGO:00695410.7CCL22, CCR4, CCL19, CCL21, CCL17, CXCL10
7negative regulation of leukocyte apoptotic processGO:200010710.7CCL19, CCL21
8establishment of T cell polarityGO:00176810.7CCL19, CCL21
9response to prostaglandin E stimulusGO:03469510.6CCL21, CCL19
10positive regulation of dendritic cell antigen processing and presentationGO:00260610.6CCL21, CCL19
11positive regulation of cell motilityGO:200014710.6CCL19, CCL21
12positive regulation of chemotaxisGO:05092110.6CCL19, CCL21
13positive regulation of receptor-mediated endocytosisGO:04826010.5CCL21, CCL19
14dendritic cell chemotaxisGO:00240710.4CCL21, CCL19
15release of sequestered calcium ion into cytosolGO:05120910.4CCL21, CCL19
16positive regulation of neutrophil chemotaxisGO:09002310.3CCL19, CCL21
17positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.1CCL21, CCL19

Molecular functions related to Contact Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.4CCR10, CCR4
2chemokine activityGO:00800910.3CXCL10, CCL22, CCL19, CCL21, CCL17, CCL27
3CCR7 chemokine receptor bindingGO:03173210.1CCL21, CCL19

Products for genes affiliated with Contact Dermatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Contact Dermatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet