MCID: CNT001
MIFTS: 32

Contagious Pustular Dermatitis

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Contagious Pustular Dermatitis

MalaCards integrated aliases for Contagious Pustular Dermatitis:

Name: Contagious Pustular Dermatitis 12 14
Ecthyma, Contagious 12 42 69
Ecthyma Contagiosum 12
Thistle Disease 12
Scabby Mouth 12
Sheep Pox 12
Orf 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8771
ICD10 33 B08.02
ICD9CM 35 051.2
MeSH 42 D004474
UMLS 69 C0013570

Summaries for Contagious Pustular Dermatitis

Disease Ontology : 12 A viral infectious disease that results_in infection located in skin, has material basis in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has symptom lesions on the finger, hand, arm, face, and penis.

MalaCards based summary : Contagious Pustular Dermatitis, also known as ecthyma, contagious, is related to dermatitis and ecthyma. An important gene associated with Contagious Pustular Dermatitis is FOXK1 (Forkhead Box K1), and among its related pathways/superpathways is Cardiac muscle contraction. The drugs Amphetamine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Wikipedia : 72 Orf is an exanthemous disease caused by a parapox virus and occurring primarily in sheep and goats. It... more...

Related Diseases for Contagious Pustular Dermatitis

Diseases related to Contagious Pustular Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 dermatitis 10.7
2 ecthyma 10.1
3 mitochondrial genetic disorders 9.9 CYC1 MT-CYB
4 vaccinia 9.9
5 skin disease 9.9
6 breast carcinoma in situ 6.8 AKR7A2 CYC1 ELAVL2 FOXK1 GPR180 MT-CYB

Graphical network of the top 20 diseases related to Contagious Pustular Dermatitis:



Diseases related to Contagious Pustular Dermatitis

Symptoms & Phenotypes for Contagious Pustular Dermatitis

GenomeRNAi Phenotypes related to Contagious Pustular Dermatitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.97 FOXK1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.97 CYC1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.97 PRODH
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.97 FOXK1 ELAVL2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.97 PRODH
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.97 FOXK1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.97 FOXK1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.97 FOXK1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.97 FOXK1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.97 PRODH
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.97 AKR7A2 ELAVL2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.97 CYC1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.97 AKR7A2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.97 CYC1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.97 PRODH
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.97 CYC1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.97 FOXK1 PRODH AKR7A2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.97 PRODH CYC1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.97 PRODH
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.97 CYC1
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.97 CYC1
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.97 CYC1 AKR7A2
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.97 PRODH

Drugs & Therapeutics for Contagious Pustular Dermatitis

Drugs for Contagious Pustular Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphetamine Approved, Illicit Phase 4 300-62-9 5826 3007
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
4
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
5 adderall Phase 4
6 Adrenergic Agents Phase 4
7 Adrenergic Agonists Phase 4
8 Adrenergic alpha-2 Receptor Agonists Phase 4
9 Adrenergic alpha-Agonists Phase 4
10 Antihypertensive Agents Phase 4
11 Atomoxetine Hydrochloride Phase 4
12 Autonomic Agents Phase 4
13 Central Nervous System Stimulants Phase 4
14 Dopamine Agents Phase 4
15 Dopamine Uptake Inhibitors Phase 4
16 Neurotransmitter Agents Phase 4
17 Neurotransmitter Uptake Inhibitors Phase 4
18 Peripheral Nervous System Agents Phase 4,Phase 1
19
Irinotecan Approved, Investigational Phase 3 97682-44-5, 100286-90-6 60838
20
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
21
Iron Approved Phase 2, Phase 3 7439-89-6 23925
22
Camptothecin Experimental Phase 3 7689-03-4
23 Dermatologic Agents Phase 3,Phase 2
24 Emollients Phase 3
25 Antineoplastic Agents, Phytogenic Phase 3
26 topoisomerase I inhibitors Phase 3
27 Topoisomerase Inhibitors Phase 3
28 Chelating Agents Phase 2, Phase 3
29 Iron Chelating Agents Phase 2, Phase 3
30 Titanium dioxide Approved Phase 2 13463-67-7
31
Ethanol Approved Phase 2 64-17-5 702
32 Photosensitizing Agents Phase 2
33 Protective Agents Phase 2
34 Radiation-Protective Agents Phase 2
35 Sunscreening Agents Phase 2
36 Anti-Infective Agents Phase 2
37 Anti-Infective Agents, Local Phase 2
38 Central Nervous System Depressants Phase 2,Phase 1
39 Pharmaceutical Solutions Phase 2
40
Oxycodone Approved, Illicit, Investigational Phase 1 76-42-6 5284603
41 Analgesics Phase 1
42 Analgesics, Opioid Phase 1
43 Narcotics Phase 1
44
Propranolol Approved, Investigational 525-66-6 4946
45
Propylthiouracil Approved 51-52-5 657298
46 Adrenergic Antagonists
47 Adrenergic beta-Antagonists
48 Anti-Arrhythmia Agents
49 Antimetabolites
50 Antithyroid Agents

Interventional clinical trials:

(show all 21)

id Name Status NCT ID Phase Drugs
1 Interventions for Children With Attention and Reading Disorders Completed NCT01133847 Phase 4 Methylphenidate;Mixed Salt Amphetamine;Atomoxetine;Guanfacine
2 Long-term Efficacy and Safety of V0034 CR 01B Cream in Patients With Moderate-to-severe Uremic Xerosis Completed NCT01084148 Phase 3 V0034CR01B;V0034CR01B vehicle
3 Efficacy, Local Tolerance and Patient Acceptability of a Moisturizing Emollient in Patients With Uremic Xerosis Completed NCT01084720 Phase 3 V0034 CR
4 Irinotecan Versus Only Best Supportive Care for Gastric Cancer Completed NCT00144378 Phase 3 Irinotecan
5 Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis Not yet recruiting NCT03293069 Phase 2, Phase 3 Deferiprone;Placebo Oral Tablet
6 Evaluation of the Protection Activity of Microfine Titanium Dioxide (Ti02), Pigmentary Ti02 and Bisoctrizole and Their Combinations in Voluntary Patients With Idiopathic Solar Urticaria (SU) Completed NCT00483496 Phase 2 Titanium dioxide (Ti02) microfine 12.15% alone (formula RV3131A-MV1209);Ti02 pigmentary 3% alone (formula RV3131A-MV1211);bisoctrizole 10% alone (formula RV3131A-MV1237);Ti02 microfine 12.15% + Ti02 pigmentary 3% (formula RV3131A-MV1213);Ti02 microfine 12.15% + bisoctrizole 10% (formula RV3131A-MV1329);Ti02 pigmentary 3% + bisoctrizole 10% (formula RV3131A-MV1212);Ti02 microfine 12.15% + Ti02 pigmentary 3% + bisoctrizole 10% [V0096 CR (formula RV3131A-MV1166)];V0096 CR vehicle (formula RV3131A-MV1197)
7 Systemic and Local Diffusion of Ethanol After Administration of Ethanol 96% Formulated in a Gel and Ethanol 98% Solution by the Percutaneous Route, in Patients With Congenital Venous Malformations:Pharmacokinetic, Pharmacodynamic and Clinical Study. Completed NCT00462462 Phase 2 Ethanol 96% Gel;Ethanol 98% Solution
8 Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR-ORF15 Mutations Not yet recruiting NCT03316560 Phase 1, Phase 2
9 Pharmacokinetics and Safety of ORF Tablets in Pediatric Patients Completed NCT01160614 Phase 1 Oxycodone hydrochloride controlled-release (ORF) tablets
10 Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348672
11 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
12 Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS Recruiting NCT02686268
13 Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation Recruiting NCT01925196
14 Predict to Prevent Frontotemporal Lobar Degeneration (FDT) and Amyotrophic Lateral Sclerosis (ALS) Recruiting NCT02590276
15 Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Recruiting NCT02372773
16 Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism Recruiting NCT02812888 thionamide treatment for 3 months
17 Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders Recruiting NCT01459302
18 The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study Recruiting NCT00317616
19 Protocol TARC-ABPA Active, not recruiting NCT01710930
20 The Epidemiology of Hepatitis E Virus Infection in Israel and Potential Risk Factors Enrolling by invitation NCT02419625
21 Clinical Evaluation of Patients With X-linked Retinitis Pigmentosa (XLRP) Not yet recruiting NCT03314207

Search NIH Clinical Center for Contagious Pustular Dermatitis

Cochrane evidence based reviews: ecthyma, contagious

Genetic Tests for Contagious Pustular Dermatitis

Anatomical Context for Contagious Pustular Dermatitis

MalaCards organs/tissues related to Contagious Pustular Dermatitis:

39
Skin, Eye, Testes

Publications for Contagious Pustular Dermatitis

Articles related to Contagious Pustular Dermatitis:

(show all 37)
id Title Authors Year
1
Isolation and molecular characterization of contagious pustular dermatitis virus from Rajasthan, India. ( 25674607 )
2014
2
Orf: contagious pustular dermatitis. ( 20666089 )
2010
3
Molecular and virological studies on contagious pustular dermatitis isolates from Egyptian sheep and goats. ( 20304450 )
2010
4
Orf (contagious pustular dermatitis) in farmworkers: prevalence and risk factors in three areas of England. ( 10452390 )
1999
5
Western blot analysis of virus-specific antibody responses for capripox and contagious pustular dermatitis viral infections in sheep. ( 7925674 )
1994
6
Contagious pustular dermatitis (orf) infection in sheep and goats in Saudi Arabia. ( 1909477 )
1991
7
Molecular analysis of contagious pustular dermatitis virus: a simplified method for viral DNA extraction from scab material. ( 1816256 )
1991
8
Detection of contagious pustular dermatitis virus of goats in a severe outbreak. ( 2588444 )
1989
9
Orf: contagious pustular dermatitis. ( 3179870 )
1988
10
Contagious pustular dermatitis (orf) of sheep affecting the ear following ear tagging. ( 3606509 )
1987
11
Contagious pustular dermatitis of sheep--possible confusion with vesicular diseases. ( 4004656 )
1985
12
Antigenic relationships among sheep pox, goat pox and contagious pustular dermatitis viruses. ( 6151351 )
1984
13
Prevalence of contagious pustular dermatitis (orf) in six million lambs at slaughter: a three-year study. ( 16030998 )
1983
14
Cross-neutralization tests on sheep pox, goat pox and contagious pustular dermatitis viruses. ( 90458 )
1979
15
Contagious pustular dermatitis of sheep in a veterinary student. ( 584593 )
1977
16
Cytopathogenicity of contagious pustular dermatitis virus in primary cell culture with special reference to the formation of intracytoplasmic inclusions. ( 4675558 )
1972
17
The vaccination of young lambs against contagious pustular dermatitis. ( 5555757 )
1971
18
Propagation of contagious pustular dermatitis virus in HeLa cell cultures. ( 5169601 )
1971
19
Possible "orf" (contagious pustular dermatitis, contagious ecthyma of sheep) infection in the dog. ( 5494712 )
1970
20
An outbreak of contagious pustular dermatitis associated with Dermatophilus congolensis infection. ( 5274960 )
1970
21
A case of orf (ecthyma contagiosum; contagious pustular dermatitis) contracted by a human from a wild Alaskan mountain goat. ( 4297665 )
1968
22
Growth of contagious pustular dermatitis virus in human tissue cultures. ( 14467780 )
1961
23
Studies with a strain of contagious pustular dermatitis virus in tissue culture. ( 14433531 )
1959
24
Contagious pustular dermatitis. IV. Immunological reactions. ( 13502481 )
1958
25
The immunological relations of the contagious pustular dermatitis virus to the mammalian pox group. ( 13596274 )
1958
26
Contagious pustular dermatitis. III. Experimental infection. ( 13481166 )
1957
27
Contagious pustular dermatitis. II. Pathological histology. ( 13449179 )
1957
28
Contagious pustular dermatitis virus. I. Studies on morphology. ( 13416415 )
1957
29
Human infections with the virus of ovine contagious pustular dermatitis (scabby mouth). ( 13430966 )
1957
30
Orf: contagious pustular dermatitis of sheep. ( 13361058 )
1956
31
Complement-fixation tests in the diagnosis of contagious pustular dermatitis infection in man. ( 14898387 )
1951
32
Human infection with the virus of contagious pustular dermatitis. ( 14814843 )
1951
33
The immunological relationship between a new virus, proliferative dermatitis of the legs (strawberry foot rot) of sheep, and the viruses of vaccinia and contagious pustular dermatitis. ( 18099893 )
1948
34
A case of orf; contagious pustular dermatitis; identification of the virus. ( 18123062 )
1948
35
The immunological relationships of strains of contagious pustular dermatitis virus. ( 20293732 )
1947
36
The relationship between the virus of contagious pustular dermatitis and a virus isolated from sheep papillomatosis by Selbie. ( 20293733 )
1947
37
Infection of man by the virus of contagious pustular dermatitis of sheep. ( 20279048 )
1946

Variations for Contagious Pustular Dermatitis

Expression for Contagious Pustular Dermatitis

Search GEO for disease gene expression data for Contagious Pustular Dermatitis.

Pathways for Contagious Pustular Dermatitis

Pathways related to Contagious Pustular Dermatitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.52 CYC1 MT-CYB

GO Terms for Contagious Pustular Dermatitis

Cellular components related to Contagious Pustular Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.33 CYC1 MT-CYB PRODH
2 respiratory chain GO:0070469 8.96 CYC1 MT-CYB
3 mitochondrial respiratory chain complex III GO:0005750 8.62 CYC1 MT-CYB

Biological processes related to Contagious Pustular Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.46 AKR7A2 CYC1 MT-CYB PRODH
2 mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8.96 CYC1 MT-CYB
3 response to glucagon GO:0033762 8.62 CYC1 MT-CYB

Molecular functions related to Contagious Pustular Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.13 AKR7A2 MT-CYB PRODH
2 electron carrier activity GO:0009055 8.8 AKR7A2 CYC1 MT-CYB

Sources for Contagious Pustular Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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