MCID: CNV002
MIFTS: 42

Conversion Disorder malady

Rare diseases, Mental diseases, Neuronal diseases categories

Summaries for Conversion Disorder

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NIH Rare Diseases:41 Conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained. symptoms may occur because of emotional distress or psychological problems. they usually begin suddenly after a stressful experience. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 5/21/2014

MalaCards based summary: Conversion Disorder, also known as hysterical neurosis, conversion type, is related to anorexia nervosa and anxiety disorder. An important gene associated with Conversion Disorder is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. The compounds pyridoxal 5-phosphate and dopac have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Disease Ontology:9 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia:63 A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness,... more...

Aliases & Classifications for Conversion Disorder

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Conversion Disorder, Aliases & Descriptions:

Name: Conversion Disorder 9 41 60
Hysterical Neurosis, Conversion Type 9
Functional Neurological Disorder 41
Conversion Hysterical Neurosis 9
Functional Movement Disorder 41
 
Dissociative Disorder 60
Frontonasal Dysplasia 60
Conversion Hysteria 9
Reaction 9
Fnd 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology9 DOID:1768
MeSH33 D003291
ICD9CM27 300.11
ICD1025 F43.9

Related Diseases for Conversion Disorder

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Diseases related to Conversion Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa30.2BDNF, COMT
2anxiety disorder29.6BDNF, GAD1, COMT
3mental retardation29.5BDNF, COMT
4dissociative disorder10.3
5dystonia10.2
6polyradiculoneuropathy10.2
7torsion dystonia10.2
8reflex sympathetic dystrophy10.2
9alexithymia10.2
10hemiplegia10.1
11frontonasal dysplasia 110.1
12follicular lymphoma10.1
13alcohol dependence10.0GAD1, COMT
14diabetes mellitus, insulin-dependent10.0GAD1, COMT
15bulimia nervosa10.0COMT, BDNF
16obsessive-compulsive disorder10.0BDNF, COMT
17schizophrenia10.0COMT, BDNF
18eating disorder10.0BDNF, COMT
19attention deficit-hyperactivity disorder10.0COMT, BDNF
20major depressive disorder and accelerated response to antidepressant drug treatment10.0BDNF, GAD1
21status epilepticus10.0GAD1, BDNF
22parkinson disease, late-onset9.9BDNF, COMT
23west nile virus9.9
24brain injury9.9
25leukemia9.9
26locked-in syndrome9.9
27addison's disease9.9
28multiple chemical sensitivity9.9
29sensorineural hearing loss9.9
30epidural abscess9.9
31hypochondriasis9.9
32cerebritis9.9
33dissociative amnesia9.9
34arachnoiditis9.9
35somatization disorder9.9
36spinal cord astrocytoma9.9
37acute disseminated encephalomyelitis9.9
38astrocytoma9.9
39complex regional pain syndrome9.9
40guillain-barre syndrome9.9
41learning disability9.9
42myeloid leukemia9.9
43paraplegia9.9
44ptosis9.9
45tetanus9.9
46neurologic diseases9.9
47arachnoid cysts9.9
48pandas9.9
49head injury9.9
50tremor9.9

Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to conversion disorder

Symptoms for Conversion Disorder

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Drugs & Therapeutics for Conversion Disorder

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Drug clinical trials:

Search ClinicalTrials for Conversion Disorder

Search NIH Clinical Center for Conversion Disorder

Genetic Tests for Conversion Disorder

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Anatomical Context for Conversion Disorder

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MalaCards organs/tissues related to Conversion Disorder:

31
Brain, Spinal cord, Cortex, Myeloid, Cingulate cortex, Pituitary

Animal Models for Conversion Disorder or affiliated genes

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MGI Mouse Phenotypes related to Conversion Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.7BDNF, GAD1
2MP:00053868.5BDNF, GAD1, COMT

Publications for Conversion Disorder

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Articles related to Conversion Disorder:

(show top 50)    (show all 267)
idTitleAuthorsYear
1
Pituitary volumes are changed in patients with conversion disorder. (25877743)
2015
2
Hospital revisit rate after a diagnosis of conversion disorder. (25855400)
2015
3
Monolimb paralysis after laparoscopic appendectomy due to conversion disorder. (25426280)
2014
4
The relationship between temperament and character in conversion disorder and comorbid depression. (23218680)
2013
5
Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. (23626829)
2013
6
Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder. (23613193)
2013
7
Neuropsychological function and memory suppression in conversion disorder. (23582098)
2013
8
Action-effect binding is decreased in motor conversion disorder: implications for sense of agency. (23494975)
2013
9
Conversion disorder. (23622298)
2013
10
The chiropractic care of a child with extremity tremors concomitant with a medical diagnosis of conversion disorder. (22500845)
2012
11
The neural circuitry of conversion disorder and its recovery. (21859163)
2012
12
Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder. (21935985)
2011
13
Conversion disorder as initial diagnosis in pantothenate kinase associated neurodegeneration. (20717690)
2011
14
Treatment of conversion disorder in the 21st century: have we moved beyond the couch? (21468672)
2011
15
Conversion disorder: understanding the pathogenic links between emotion and motor systems in the brain. (20418528)
2010
16
Valproate in conversion disorder: a case report. (20671980)
2010
17
Abreaction for conversion disorder: systematic review with meta-analysis. (20679259)
2010
18
Increased activation in cingulate cortex in conversion disorder: what does it mean? (19733363)
2010
19
The involuntary nature of conversion disorder. (20083798)
2010
20
The neuropsychiatry of conversion disorder. (18382227)
2008
21
Physical therapy management for conversion disorder: case series. (17419887)
2007
22
Conversion disorder in Australian pediatric practice. (17195731)
2007
23
Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey. (17639308)
2007
24
Clinical profile and outcome of conversion disorder in children in a tertiary hospital of north India. (17459885)
2007
25
Conversion disorder: towards a neurobiological understanding. (19412442)
2006
26
Volumetric investigation of brain regions in patients with conversion disorder. (16600450)
2006
27
Healing the disembodied mind: contemporary models of conversion disorder. (15804930)
2005
28
Urinary retention, erectile dysfunction and penile anaesthesia after circumcision: a mixed dissociative (conversion) disorder. (16307335)
2005
29
Progress in understanding conversion disorder. (18568070)
2005
30
Case report: physiotherapy strategies for a patient with conversion disorder presenting abnormal gait. (16245757)
2005
31
Conversion disorder in a child presenting as sudden sensorineural hearing loss. (15964081)
2005
32
Sociodemographic and clinical characteristics of patients with conversion disorder in Eastern Turkey. (12563551)
2003
33
A randomized controlled clinical trial of a hypnosis-based treatment for patients with conversion disorder, motor type. (12825917)
2003
34
Deception or misinterpretation in case of a conversion disorder? (14630461)
2003
35
Conversion disorder in children and adolescents: a 4-year follow-up study. (11943237)
2002
36
Conversion disorder: difficulties in diagnosis using DSM-IV/ICD-10. (11759495)
2001
37
Reevaluation of serum cortisol in conversion disorder with seizure (pseudoseizure) (10749955)
2000
38
Polysymptomatic conversion disorder in childhood and adolescence in Japan. Early manifestation or incomplete form of somatization disorder? (10773777)
2000
39
Organic syndromes diagnosed as conversion disorder: identification and frequency in a study of 85 patients. (11053598)
2000
40
Conversion disorder and multiple chemical sensitivity: a comparative study of psychological defense strategies. (11153853)
2000
41
Distinguishing conversion disorder from neurologic impairment. (9140848)
1997
42
Conversion disorder presenting as a head injury. (9248922)
1997
43
Conversion disorder after maxillofacial trauma and surgery. (8727582)
1996
44
Hoarseness after cardiac operations: vocal cord paralysis or a conversion disorder? (8823130)
1996
45
Conversion disorder presenting as gait disturbance in an adolescent. (7647948)
1995
46
Diagnostic issues for conversion disorder. (1427673)
1992
47
Hyperemesis gravidarum as conversion disorder. (2230751)
1990
48
Visual conversion disorder: a case analysis of the influence of visual information. (2768670)
1989
49
The use of contingent reinforcement in the treatment of a conversion disorder: a multiple baseline study. (4086655)
1985
50
Factitious illness v conversion disorder. (6854863)
1983

Variations for Conversion Disorder

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Expression for genes affiliated with Conversion Disorder

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Search GEO for disease gene expression data for Conversion Disorder.

Pathways for genes affiliated with Conversion Disorder

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Compounds for genes affiliated with Conversion Disorder

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Compounds related to Conversion Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pyridoxal 5-phosphate439.7COMT, GAD1
2dopac439.6BDNF, COMT
3mhpg439.6COMT, BDNF
4antipsychotics499.6BDNF, COMT
5maoa439.6BDNF, COMT
6homovanillic acid43 2410.6BDNF, COMT
7pramipexole43 28 49 1212.5BDNF, COMT
8fluvoxamine43 49 1211.5BDNF, COMT
9venlafaxine43 49 24 1212.5BDNF, COMT
10selegiline43 1210.5COMT, BDNF
11heroin43 49 1211.5COMT, BDNF
12paroxetine43 49 28 1212.5BDNF, COMT
13methamphetamine43 49 1211.5COMT, BDNF
14risperidone43 49 28 59 24 1214.5BDNF, COMT
156-hydroxydopamine439.5BDNF, COMT
16olanzapine43 49 28 24 1213.5COMT, BDNF
17bicuculline43 2810.5BDNF, GAD1
18quinolinic acid43 2410.4BDNF, GAD1
19catecholamine439.4COMT, BDNF
20muscimol43 59 2811.4GAD1, BDNF
21valproate439.4GAD1, BDNF
22cocaine43 1210.4COMT, BDNF
23streptozotocin439.4GAD1, BDNF
24valine439.4BDNF, COMT
25tetrodotoxin43 59 2811.4BDNF, GAD1
26haloperidol43 49 28 2 1213.3BDNF, GAD1
27kainate43 2810.3GAD1, BDNF
28valproic acid43 49 24 1212.3BDNF, GAD1
29gold439.3BDNF, GAD1
30epinephrine43 24 1211.3BDNF, COMT
31bromodeoxyuridine439.3BDNF, GAD1
32ascorbic acid43 2410.2BDNF, COMT
33gnrh439.2BDNF, GAD1
34gaba439.2GAD1, BDNF
35tamoxifen43 49 28 1212.2BDNF, COMT
36ethanol43 49 24 1212.1COMT, BDNF
37norepinephrine43 24 1211.0BDNF, COMT
38potassium43 24 1211.0BDNF, GAD1
39mptp439.0BDNF, GAD1, COMT
40levodopa43 1210.0BDNF, GAD1, COMT
41clozapine43 28 49 1212.0COMT, GAD1, BDNF
42choline43 24 1211.0BDNF, GAD1, COMT
43methionine439.0COMT, GAD1, BDNF
44nmda43 289.9BDNF, GAD1, COMT
45estradiol43 24 1210.9COMT, GAD1, BDNF
46proline438.9COMT, GAD1, BDNF
47hydrogen43 249.9COMT, GAD1, BDNF
48dopamine43 28 24 1211.9COMT, GAD1, BDNF
49glutamate438.8BDNF, GAD1, COMT
50acetylcholine43 49 28 24 1212.7BDNF, GAD1

GO Terms for genes affiliated with Conversion Disorder

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Biological processes related to Conversion Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00072689.3GAD1, COMT
2neurotransmitter biosynthetic processGO:00421369.2GAD1, COMT
3response to drugGO:00424939.0GAD1, COMT

Products for genes affiliated with Conversion Disorder

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Sources for Conversion Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet