FND
MCID: CNV002
MIFTS: 50

Conversion Disorder (FND) malady

Neuronal diseases category

Summaries for Conversion Disorder

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained. symptoms may occur because of emotional distress or psychological problems. they usually begin suddenly after a stressful experience. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 9/20/2010

MalaCards: Conversion Disorder, also known as hysterical neurosis, conversion type, is related to herpes simplex and neuroblastoma. An important gene associated with Conversion Disorder is BDNF (brain-derived neurotrophic factor). The compounds bicuculline and muscimol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone marrow, and related mouse phenotype taste/olfaction.

Disease Ontology:8 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia:63 A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness,... more...

Aliases & Classifications for Conversion Disorder

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

conversion disorder 8 42 60
hysterical neurosis, conversion type 8
functional neurological disorder 42
conversion hysterical neurosis 8
functional movement disorder 42
frontonasal dysplasia 60
conversion hysteria 8
reaction 8
fnd 42


External Ids:

Disease Ontology8 DOID:1768
MeSH34 D003291
ICD9CM27 300.11
ICD1025 F43.9

Related Diseases for Conversion Disorder

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to conversion disorder

Clinical Features for Conversion Disorder

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Drugs & Therapeutics for Conversion Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Conversion Disorder

Search CenterWatch for Conversion Disorder

Genetic Tests for Conversion Disorder

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Anatomical Context for Conversion Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Conversion Disorder:

32
Brain, Spinal cord, Bone marrow, Bone, Cortex, Myeloid, T cells, Cingulate cortex

Animal Models for Conversion Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Conversion Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.0GAD1, BDNF

Publications for Conversion Disorder

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50PubMed
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Articles related to Conversion Disorder:

(show top 50)    (show all 268)
idTitleAuthorsYear
1
Neural correlates of recall of life events in conversion disorder. (24258270)
2014
2
Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. (23626829)
2013
3
Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder. (23613193)
2013
4
Using Self-Management to Improve the Reciprocal Social Conversation of Children with Autism Spectrum Disorder. (24127164)
2013
5
Predictors of suicide in patients with conversion disorder. (24269192)
2013
6
Validity of the "Drift without pronation" sign in conversion disorder. (23548051)
2013
7
Alexithymia in patients with conversion disorder. (23902128)
2013
8
Incidence and 12-month outcome of non-transient childhood conversion disorder in the U.K. and Ireland. (23620449)
2013
9
Differences in MMPI-2 FBS and RBS scores in brain injury, probable malingering, and conversion disorder groups: a preliminary study. (23510271)
2013
10
Non-transient childhood conversion disorder is uncommon in the UK and Ireland, but use of services is high. (24001552)
2013
11
Altered Th17 cells and Th17/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders. (23974054)
2013
12
Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder. (21935985)
2011
13
Conversion disorder: understanding the pathogenic links between emotion and motor systems in the brain. (20418528)
2010
14
Valproate in conversion disorder: a case report. (20671980)
2010
15
Conversion disorder after surgery in a brain tumour patient. (20437949)
2010
16
Emotional stimuli and motor conversion disorder. (20371508)
2010
17
Conversion disorder in women with the FMR1 premutation. (19842197)
2009
18
Systematic enhancement of functioning as a therapeutic technique in conversion disorder. (19823633)
2009
19
Two stiff person cases misdiagnosed as conversion disorder]. (20013431)
2009
20
Pediatric case study and review: is it a conversion disorder? (18724569)
2008
21
Conversion disorder in Australian pediatric practice. (17195731)
2007
22
A study of clinical correlates and socio-demographic profile in conversion disorder. (20661388)
2007
23
Temperamental traits associated with conversion disorder. (17079833)
2006
24
A case of conversion disorder presenting as a severe acute stroke. (16677978)
2006
25
A homozygous nonsense mutation in SOX9 in the dominant disorder campomelic dysplasia: a case of mitotic gene conversion. (15806394)
2005
26
A randomized controlled clinical trial of a hypnosis-based treatment for patients with conversion disorder, motor type. (12825917)
2003
27
Misdiagnosis of conversion disorder. (12562606)
2003
28
Conversion disorder after implant of a spinal cord stimulator in a patient with a complex regional pain syndrome. (12505953)
2003
29
What is wrong in conversion disorder? (12700288)
2003
30
Hysterical conversion disorder in a young girl at moderate altitude. (11929064)
2002
31
Conversational behaviour of children with Asperger syndrome and conduct disorder. (12120863)
2002
32
Conversion disorder: difficulties in diagnosis using DSM-IV/ICD-10. (11759495)
2001
33
Palilalia as a conversion disorder. (11351121)
2001
34
A case of bilateral ptosis with unsteady gait: suggestibility and culture in conversion disorder. (11760865)
2001
35
Conversion disorder presenting as multiple sclerosis. (9795550)
1998
36
Illness behavior in the acute phase of motor disability in neurological disease and in conversion disorder: a comparative study. (9678747)
1998
37
Unusual presentation of a child with conversion disorder. (9494752)
1998
38
Behavioral management of conversion disorder in children. (9084347)
1997
39
Corticospinal function in conversion disorder. (9144115)
1997
40
Behavioral management of conversion disorder: retrospective study. (8607738)
1996
41
Outcome in conversion disorder: a follow up study. (7608683)
1995
42
Cognitive impairment related to conversion disorder: a two-year follow-up study. (8501450)
1993
43
The misdiagnosis of conversion disorder in a psychiatric emergency service. (1592252)
1992
44
Diagnosis and management of psychogenic stridor caused by a conversion disorder. (2371109)
1990
45
Lorazepam in the treatment of acute conversion disorder. (2249809)
1990
46
Conversion disorder (DSM-III 300.11): symptomatology and course in childhood and adolescence. (2721533)
1989
47
DSM-III-R conversion disorder and the unconscious. (3414864)
1988
48
The differentiation of vomiting/weight loss as a conversion disorder from anorexia nervosa. (6869584)
1983
49
Guillain-BarrAc misdiagnosed as conversion disorder. (7129394)
1982
50
Dividing "hysteria": a preliminary investigation of conversion disorder and psychalgia. (448337)
1979

Genetic Variations for Conversion Disorder

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Expression for genes affiliated with Conversion Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conversion Disorder

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Pathways for genes affiliated with Conversion Disorder

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Compounds for genes affiliated with Conversion Disorder

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Conversion Disorder according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1bicuculline44 2811.1GAD1
2muscimol44 59 2812.0GAD1
3dopac449.7BDNF, COMT
4mhpg449.7COMT, BDNF
5maoa449.7COMT, BDNF
6homovanillic acid44 2410.7BDNF, COMT
7pramipexole44 49 28 1112.7COMT, BDNF
8selegiline44 1110.7COMT, BDNF
9paroxetine44 49 28 1112.7BDNF, COMT
10risperidone28 44 49 59 11 2414.7BDNF, COMT
11methamphetamine44 49 1111.7COMT, BDNF
126-hydroxydopamine449.6BDNF, COMT
13olanzapine49 44 28 11 2413.6BDNF, COMT
14catecholamine449.6COMT, BDNF
15cocaine44 1110.5BDNF, COMT
16pyridoxal 5-phosphate449.5COMT, GAD1
17quinolinic acid44 2410.4GAD1, BDNF
18valine449.4BDNF, COMT
19valproate449.4BDNF, GAD1
20streptozotocin449.3BDNF, GAD1
21ascorbic acid44 2410.3BDNF, COMT
22tetrodotoxin44 59 2811.3BDNF, GAD1
23haloperidol44 28 2 49 1113.3BDNF, GAD1
24valproic acid44 49 11 2412.3BDNF, GAD1
25kainate44 2810.2BDNF, GAD1
26gold449.2GAD1, BDNF
27bromodeoxyuridine449.1BDNF, GAD1
28gnrh449.0GAD1, BDNF
29epinephrine44 11 2411.0BDNF, COMT
30mptp448.9GAD1, BDNF, COMT
31levodopa44 119.9COMT, BDNF, GAD1
32clozapine44 28 49 1111.9GAD1, BDNF, COMT
33gaba448.9BDNF, GAD1
34choline44 11 2410.9COMT, BDNF, GAD1
35methionine448.9GAD1, BDNF, COMT
36nmda44 289.9GAD1, BDNF, COMT
37estradiol44 11 2410.9GAD1, BDNF, COMT
38proline448.9COMT, BDNF, GAD1
39hydrogen44 249.9GAD1, BDNF, COMT
40dopamine44 28 11 2411.9COMT, BDNF, GAD1
41glutamate448.8GAD1, BDNF, COMT

GO Terms for genes affiliated with Conversion Disorder

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16Gene Ontology
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Biological processes related to Conversion Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424939.1GAD1, COMT
2neurotransmitter biosynthetic processGO:0421368.8GAD1, COMT

Products for genes affiliated with Conversion Disorder

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Sources for Conversion Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet