MCID: CNV002
MIFTS: 42

Conversion Disorder

Categories: Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Conversion Disorder

MalaCards integrated aliases for Conversion Disorder:

Name: Conversion Disorder 12 72 49 41 14 69
Hysterical Neurosis, Conversion Type 12
Functional Neurological Disorder 49
Conversion Hysteria or Reaction 12
Conversion Hysterical Neurosis 12
Functional Movement Disorder 49
Dissociative Disorder 69
Fnd 49

Classifications:



External Ids:

Disease Ontology 12 DOID:1768
ICD10 32 F44
ICD9CM 34 300.11
MeSH 41 D003291
UMLS 69 C0009946

Summaries for Conversion Disorder

NIH Rare Diseases : 49 Conversion disorder is a disorder in which a person experiences blindness, paralysis, or other symptoms affecting the nervous system that cannot be explained solely by a physical illness or injury. Symptoms usually begin suddenly after a period of emotional or physical distress or psychological conflict. Conversion disorder is thought to be caused by the body’s reaction to a stressful physical or emotional event. Some research has identified potential neurological changes that may be related to symptoms of the disorder. Diagnosis of conversion disorder is based on identifying particular signs that are common among people with the disorder, as well as performing tests to rule out other causes of the symptoms. Treatment may include psychotherapy, hypnosis, and stress management training to help reduce symptoms. Treatment of any underlying psychological disorder is also recommended. The affected body part may require physical or occupational therapy until symptoms resolve. Last updated: 8/18/2017

MalaCards based summary : Conversion Disorder, also known as hysterical neurosis, conversion type, is related to frontonasal dysplasia 1 and psychogenic movement, and has symptoms including waxy flexibility An important gene associated with Conversion Disorder is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways is Biogenic Amine Synthesis. The drugs Ranibizumab and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related phenotype is respiratory system.

Disease Ontology : 12 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia : 72 Conversion disorder (CD) is a diagnostic category used in some psychiatric classification systems. It is... more...

Related Diseases for Conversion Disorder

Diseases related to Conversion Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 frontonasal dysplasia 1 11.9
2 psychogenic movement 11.2
3 six2-related frontonasal dysplasia 10.9
4 dissociative disorder 10.6
5 lymphoma 10.0
6 childhood-onset schizophrenia 9.9 COMT GAD1
7 dissociative amnesia 9.9
8 dissociative seizures 9.9
9 alexithymia 9.8
10 dysbaric osteonecrosis 9.8 ALX3 COMT
11 reflex sympathetic dystrophy 9.8
12 anxiety 9.8
13 bulimia nervosa 2 9.8
14 episodic pain syndrome, familial, 1 9.8
15 algoneurodystrophy 9.8
16 disease of mental health 9.7 COMT GAD1
17 multiple sclerosis 9.7
18 aging 9.7
19 hemiplegia 9.7
20 epilepsy 9.7
21 chorea, childhood-onset, with psychomotor retardation 9.6
22 pulmonary hypertension 9.6
23 choreatic disease 9.6
24 creutzfeldt-jakob disease 9.5
25 dementia, lewy body 9.5
26 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.5
27 neurodegeneration with brain iron accumulation 1 9.5
28 incontinentia pigmenti 9.5
29 paine syndrome 9.5
30 supranuclear palsy, progressive, 1 9.5
31 leukemia, acute myeloid 9.5
32 west nile virus 9.5
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.5
34 brain injury 9.5
35 leukemia 9.5
36 ptosis 9.5
37 thrombosis 9.5
38 sensorineural hearing loss 9.5
39 tetanus 9.5
40 epidural abscess 9.5
41 myopia 9.5
42 arachnoiditis 9.5
43 locked-in syndrome 9.5
44 guillain-barre syndrome 9.5
45 hypochondriasis 9.5
46 dementia 9.5
47 somatization disorder 9.5
48 astrocytoma 9.5
49 complex regional pain syndrome 9.5
50 cerebritis 9.5

Comorbidity relations with Conversion Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety
Dysthymic Disorder Esophagitis
Hypertension, Essential Hypothyroidism
Major Depressive Disorder Schizophreniform Disorder
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to Conversion Disorder

Symptoms & Phenotypes for Conversion Disorder

UMLS symptoms related to Conversion Disorder:


waxy flexibility

MGI Mouse Phenotypes related to Conversion Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 8.92 ALX3 COMT GAD1 TRAPPC9

Drugs & Therapeutics for Conversion Disorder

Drugs for Conversion Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 2,Phase 3,Phase 1 347396-82-1 459903
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
3
Sertraline Approved Phase 4 79617-96-2 68617
4
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
5
Gatifloxacin Approved, Investigational Phase 4 112811-59-3 5379
6
Gemifloxacin Approved, Investigational Phase 4 175463-14-6 9571107 5464436
7
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
8
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
9
Norfloxacin Approved Phase 4 70458-96-7 4539
10
Ofloxacin Approved Phase 4 82419-36-1 4583
11
Rasagiline Approved Phase 4 136236-51-6 3052776
12
Verteporfin Approved, Investigational Phase 4 129497-78-5
13 Antidepressive Agents Phase 4
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
15 Neurotransmitter Uptake Inhibitors Phase 4
16 Psychotropic Drugs Phase 4,Phase 2,Phase 3
17
Serotonin Phase 4 50-67-9 5202
18 Serotonin Agents Phase 4
19 Serotonin Uptake Inhibitors Phase 4
20 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
21 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1
22 triamcinolone acetonide Phase 4,Phase 3
23 Triamcinolone diacetate Phase 4,Phase 3
24 Triamcinolone hexacetonide Phase 4,Phase 3
25 Anti-Bacterial Agents Phase 4
26 Anti-Infective Agents Phase 4
27 beta-Lactams Phase 4
28 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
29 Cytochrome P-450 Enzyme Inhibitors Phase 4
30 Fluoroquinolones Phase 4
31 Lactams Phase 4
32 Norgestimate, ethinyl estradiol drug combination Phase 4
33 Nucleic Acid Synthesis Inhibitors Phase 4
34 Renal Agents Phase 4
35 Topoisomerase Inhibitors Phase 4
36 Monoamine Oxidase Inhibitors Phase 4
37 Neuroprotective Agents Phase 4
38 Protective Agents Phase 4
39 Immunosuppressive Agents Phase 4,Phase 3
40 Dermatologic Agents Phase 4
41 Photosensitizing Agents Phase 4
42
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
43
Chlorhexidine Approved, Vet_approved Phase 2, Phase 3 55-56-1 2713 9552079
44
Temazepam Approved, Investigational Phase 3,Phase 2 846-50-4 5391
45
Dalteparin Approved Phase 3 9005-49-6
46
Fluorouracil Approved Phase 3 51-21-8 3385
47
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
48
Iodine Approved, Investigational Phase 3 7553-56-2 807
49
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
50
Povidone Approved Phase 3 9003-39-8

Interventional clinical trials:

(show top 50) (show all 99)

# Name Status NCT ID Phase Drugs
1 On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD) Unknown status NCT01670162 Phase 4 Aflibercept
2 Treatments for Psychogenic Nonepileptic Seizures (NES) Completed NCT00159965 Phase 4 sertraline;placebo
3 Treatment Trial for Psychogenic Nonepileptic Seizures Completed NCT00835627 Phase 4 sertraline
4 An Observational Study of Oral Fluoroquinolones and the Risk of Retinal Detachment Completed NCT01881438 Phase 4
5 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4 Aflibercept
6 Intravitreal Ranibizumab in Retinal Pigment Epithelial Detachments Completed NCT00976222 Phase 4 intravitreal injection with ranibizumab
7 Eylea to Treat Retinal Pigment Epithelial Detachment (RPED) Secondary to Wet Age-Related Macular Degeneration (wAMD) Completed NCT02142296 Phase 4 Eylea
8 Rasagiline (Azilect) - Neuroprotection for Macula-off Retinal Detachment Recruiting NCT02068625 Phase 4 Rasagiline;Placebo
9 Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy Withdrawn NCT01666236 Phase 4
10 Pressurized PPV 23GA Vitrectomy in Complicated Diabetic Tractional Retinal Detachment Unknown status NCT00404209 Phase 3
11 Comparison High-Density Silicone Oils in Retinal Detachment Unknown status NCT00403702 Phase 2, Phase 3 Oxane HD [oil-RMN3-mixture];Densiron [(F6H8)
12 Surgical Management of Pseudophakic and Aphakic Retinal Detachment; a Randomized Clinical Trial Unknown status NCT00370279 Phase 3
13 Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus Completed NCT00381771 Phase 2, Phase 3
14 Lucentis for Age-related Macular Degeneration Pigment Epithelial Detachments Completed NCT00590694 Phase 2, Phase 3 ranibizumab
15 Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment. Recruiting NCT02834559 Phase 3 5-fluorouracil and low molecular weight heparin;Placebo
16 Treatment of Globus Sensations With Psychotherapy Active, not recruiting NCT01590992 Phase 2, Phase 3
17 Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy Active, not recruiting NCT01976923 Phase 3 Intravitreal bevacizumab
18 Rehabilitation of Conversion Gait Disorder Unknown status NCT01422278 Phase 1, Phase 2
19 Lucentis to Treat Pigment Epithelial Detachment Completed NCT00841581 Phase 2 Ranibizumab
20 Posterior Vitreous Detachment (PVD) Assessment During Dual Retinal Vein Occlusion (RVO) Lucentis Evaluations Completed NCT00831350 Phase 2 Ranibizumab
21 Body-Oriented Therapy for Sexual Abuse Recovery Completed NCT00097305 Phase 2
22 Ranibizumab for Diabetic Traction Retinal Detachment Completed NCT01201161 Phase 2 Ranibizumab
23 Pars Plana Vitrectomy (PPV) Versus Preoperative Intravitreal Bevacizumab Plus PPV to Treat Diabetic Tractional Retinal Detachment (IBETRA) Completed NCT00690768 Phase 2 Bevacizumab
24 Naltrexone in the Treatment of Dissociative Symptoms in Patients With Borderline Personality Disorder Completed NCT01133301 Phase 2 Naltrexone;Placebo
25 Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment Completed NCT00198471 Phase 2 Vitrase
26 Study of Denufosol (INS37217) in Subjects With Rhegmatogenous Retinal Detachment Terminated NCT00083967 Phase 2 denufosol tetrasodium (INS37217) Intravitreal Injection
27 HiPED - High Dose Lucentis for Persistent Pigment Epithelial Detachments in Age-related Macular Degeneration Terminated NCT01189019 Phase 2 ranibizumab;ranibizumab
28 Flexibility, Efficacy, and Safety of a Foldable Capsular Vitreous Body in the Treatment of Severe Retinal Detachment Unknown status NCT01261533 Phase 1
29 Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment Unknown status NCT00548197 Phase 1 Bevacizumab
30 A Study in Subjects With Retinal Detachment Completed NCT00210067 Phase 1 denufosol tetrasodium (INS37217) Intravitreal Injection
31 Ranibizumab for Treating Submacular Vascularized Pigment Epithelial Detachments Completed NCT00749021 Phase 1 Ranibizumab;Ranibizumab;Ranibizumab;Ranibizumab
32 Ursodeoxycholic Acid for Rhegmatogenous Retinal Detachment Recruiting NCT02841306 Phase 1 Ursodeoxycholic Acid
33 Psychotherapy and Pharmacotherapy in Dissociative Disorders Unknown status NCT00630981 Pharmacological treatment (Quetiapine and/or Escitalopram)
34 Psychopathology of Dissociative Disorders Unknown status NCT01388140
35 Exploration and Characterization of Genetic and Phenotypic Profile of the"Schizotiste" Unknown status NCT02565524
36 Cognitive Behavioural Therapy in Dissociative Seizures Unknown status NCT00688727
37 Multi-electrocoagulation Retinectomy for Retinal Re-detachment in Silicone Oil Filled Eye Unknown status NCT02201706
38 DOREFA (Retinal Detachment: Function and Anatomy) Unknown status NCT01767038
39 Corneal Endothelial Cell Loss After Pneumatic Retinopexy for the Repair of Primary Rhegmatogenous Retinal Detachment Unknown status NCT02185469 sulfur hexafluoride (SF6)
40 Iray for Vascularized Pigment Epithelial Detachment (VPED) Secondary to Age Related Macular Degeneration Unknown status NCT01521819 Lucentis
41 Cytokine Levels in Conversion Disorder Completed NCT00971360
42 Prevalence of Dissociative Disorders in Children Completed NCT01512641
43 Brain Activity in People With Functional Movement Disorders Completed NCT00448084
44 Treatment of Functional Movement Disorders With Psychotherapy Completed NCT01778517
45 TMS and Attentional Bias in Functional Motor Disorder Completed NCT02102906
46 Feasibility Study of Physiotherapy for Functional Motor Symptoms Completed NCT02275000
47 Exploration of the Social Cognition in Adolescents With a Dissociative Disorder or Autism Spectrum Completed NCT01805128
48 Assessment of Adverse Events in a Naive Pediatric Population Treated With an Antipsychotic Completed NCT02007928
49 Benefits of the Involvement of Nurses in Meetings Between Physicians and the Families of Patients in the ICU. Completed NCT01745406
50 Electromyographic Responses by Static Stretching and Neural Mobilization Completed NCT01379105

Search NIH Clinical Center for Conversion Disorder

Cochrane evidence based reviews: conversion disorder

Genetic Tests for Conversion Disorder

Anatomical Context for Conversion Disorder

MalaCards organs/tissues related to Conversion Disorder:

38
Eye, Testes, Brain, Endothelial, Cortex, Retina, Prefrontal Cortex

Publications for Conversion Disorder

Articles related to Conversion Disorder:

(show top 50) (show all 319)
# Title Authors Year
1
Functional neurological symptom disorder (conversion disorder): A role for microglial-based plasticity mechanisms? ( 29406995 )
2018
2
The classification of conversion disorder (functional neurologic symptom disorder) in ICD and DSM. ( 27719838 )
2017
3
Neuroanatomy of conversion disorder: towards a network approach. ( 29252202 )
2017
4
La belle indiffAcrence revisited: a case report on progressive supranuclear palsy misdiagnosed as conversion disorder. ( 28814874 )
2017
5
A Case of Sporadic Creutzfeldt-Jakob Disease Presenting as Conversion Disorder. ( 28553554 )
2017
6
Downwards Vertical Attention Bias in Conversion Disorder vs Controls: A Pilot Study. ( 28844417 )
2017
7
Symptom-specific amygdala hyperactivity modulates motor control network in conversion disorder. ( 28529870 )
2017
8
Are psychogenic non-epileptic seizures just another symptom of conversion disorder? ( 28235779 )
2017
9
Postoperative Conversion Disorder Presenting as Inspiratory Stridor and Hemiparesis in a Pediatric Patient. ( 28093564 )
2017
10
Conversion disorder or multiple sclerosis? ( 28784382 )
2017
11
Conversion Disorder Comorbidity and Childhood Trauma. ( 28566953 )
2017
12
Conversion disorder: A systematic review of current terminology. ( 28274339 )
2017
13
Stiff person case misdiagnosed as conversion disorder: A case report. ( 29201327 )
2017
14
Postoperative transient blindness after general anesthesia and surgery: case report of conversion disorder. ( 28936911 )
2017
15
Conversion Disorder, Functional Neurological Symptom Disorder, and Chronic Pain: Comorbidity, Assessment, and Treatment. ( 28434123 )
2017
16
Psychometric properties of Conversion Disorder Scale- Revised (CDS) for children. ( 28507360 )
2017
17
Evaluation of oxidant, antioxidant, and S100B levels in patients with conversion disorder. ( 27471386 )
2016
18
Functional Neuroanatomy and Neurophysiology of Functional Neurological Disorders (Conversion Disorder). ( 26900733 )
2016
19
Interdisciplinary rehabilitation approach for functional neurological symptom (conversion) disorder: A case study. ( 26689100 )
2016
20
Clinical Considerations Regarding Regression in Psychotherapy with Patients with Conversion Disorder. ( 27603802 )
2016
21
Childhood Trauma and Alexithymia in Patients with Conversion Disorder. ( 27504555 )
2016
22
The role of psychiatrists in diagnosing conversion disorder: a mixed-methods analysis. ( 27274253 )
2016
23
Poster 173 Concussions Presenting with Conversion Disorder: AA Case Series. ( 27672938 )
2016
24
Erratum: Uncovering the etiology of conversion disorder: insights from functional neuroimaging [Corrigendum]. ( 27103807 )
2016
25
Aversive stimuli exacerbate defensive motor behaviour in motor conversion disorder. ( 27842291 )
2016
26
Can motor imagery and hypnotic susceptibility explain Conversion Disorder with motor symptoms? ( 27346334 )
2016
27
Sense of body ownership in patients affected by functional motor symptoms (conversion disorder). ( 26704189 )
2016
28
Functional networks of motor inhibition in conversion disorder patients and feigning subjects. ( 27330971 )
2016
29
Life events and escape in conversion disorder. ( 27377290 )
2016
30
Poster 294 Conversion Disorder Rehabilitation: A Case Report. ( 27673051 )
2016
31
Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder. ( 27283002 )
2016
32
From conversion disorder (DSM-IV-TR) to functional neurological symptom disorder (DSM-5): When a label changes the perspective for the neurologist, the psychiatrist and the patient. ( 26723973 )
2016
33
Conversion Disorder in an Appalachian Community. ( 27490651 )
2016
34
Cognitive Behavioural Therapy and Adjunctive Physical Activity for Functional Movement Disorders (Conversion Disorder): A Pilot, Single-Blinded, Randomized Study. ( 27744440 )
2016
35
Postoperative conversion disorder. ( 27041258 )
2016
36
Demonstration of Injury of the Corticospinal Tract in a Patient with Suspected Motor Conversion Disorder. ( 27386816 )
2016
37
Uncovering the etiology of conversion disorder: insights from functional neuroimaging. ( 26834476 )
2016
38
Relationships among depression, anxiety, anxiety sensitivity, and perceived social support in adolescents with conversion disorder. ( 26824691 )
2016
39
Emotion-motion interactions in conversion disorder: an FMRI study. ( 25859660 )
2015
40
Temperament and character traits in patients with conversion disorder and their relations with dissociation. ( 26609652 )
2015
41
Childhood Trauma and Conversion Disorder in a 16-Year-Old Boy. ( 26445684 )
2015
42
Conversion disorder in a preschool age girl. ( 25972349 )
2015
43
Knowledge of conversion disorder in children by pediatricians in a developing country. ( 25966728 )
2015
44
Conversion Disorder; an Unusual Etiology of Unilateral Foot Drop. ( 26179836 )
2015
45
An atypical presentation of visual conversion disorder. ( 25744066 )
2015
46
Pituitary volumes are changed in patients with conversion disorder. ( 25877743 )
2015
47
P-wave and QT dispersion in patients with conversion disorder. ( 25848293 )
2015
48
Efficacy of brief interdisciplinary psychotherapeutic intervention for motor conversion disorder and nonepileptic attacks. ( 26099544 )
2015
49
Recurrence of conversion disorder symptoms in a successfully treated 16-year-old female. ( 26510710 )
2015
50
Hospital revisit rate after a diagnosis of conversion disorder. ( 25855400 )
2015

Variations for Conversion Disorder

Expression for Conversion Disorder

Search GEO for disease gene expression data for Conversion Disorder.

Pathways for Conversion Disorder

Pathways related to Conversion Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.97 COMT GAD1

GO Terms for Conversion Disorder

Sources for Conversion Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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