FND
MCID: CNV002
MIFTS: 49

Conversion Disorder (FND) malady

Rare diseases, Mental diseases, Neuronal diseases categories
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Summaries for Conversion Disorder

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NIH Rare Diseases:42 Conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained. symptoms may occur because of emotional distress or psychological problems. they usually begin suddenly after a stressful experience. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 5/21/2014

MalaCards based summary: Conversion Disorder, also known as conversion hysterical neurosis, is related to anorexia nervosa and anxiety disorder. An important gene associated with Conversion Disorder is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. The compounds pyridoxal 5-phosphate and dopac have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Disease Ontology:8 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia:65 A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness,... more...

Aliases & Classifications for Conversion Disorder

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Conversion Disorder, Aliases & Descriptions:

Name: Conversion Disorder 8 42 62
Conversion Hysterical Neurosis 8 62
Hysterical Neurosis, Conversion Type 8
Functional Neurological Disorder 42
Functional Movement Disorder 42
 
Frontonasal Dysplasia 62
Conversion Hysteria 8
Reaction 8
Fnd 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:1768
MeSH34 D003291
ICD9CM27 300.11
ICD1025 F43.9

Related Diseases for Conversion Disorder

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Diseases related to Conversion Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa30.2COMT, BDNF
2anxiety disorder29.6COMT, GAD1, BDNF
3multiple sclerosis29.6BDNF, GAD1, COMT
4mental retardation29.5BDNF, COMT
5frontonasal dysplasia10.5
6dissociative disorder10.3
7dystonia10.2
8polyradiculoneuropathy10.2
9torsion dystonia10.2
10reflex sympathetic dystrophy10.2
11alexithymia10.2
12hemiplegia10.1
13follicular lymphoma10.0
14type 1 diabetes mellitus10.0GAD1, COMT
15bulimia nervosa10.0COMT, BDNF
16obsessive-compulsive disorder10.0BDNF, COMT
17schizoaffective disorder10.0BDNF, COMT
18eating disorder10.0COMT, BDNF
19attention deficit hyperactivity disorder10.0COMT, BDNF
20endogenous depression10.0GAD1, BDNF
21status epilepticus10.0GAD1, BDNF
22parkinson's disease10.0BDNF, COMT
23temporal lobe epilepsy9.9BDNF, GAD1
24acute myeloid leukemia9.9
25brain injury9.9
26leukemia9.9
27addison's disease9.9
28somatization disorder9.9
29locked-in syndrome9.9
30multiple chemical sensitivity9.9
31sensorineural hearing loss9.9
32hypochondriasis9.9
33arachnoiditis9.9
34spinal cord astrocytoma9.9
35epidural abscess9.9
36cerebritis9.9
37dissociative amnesia9.9
38pantothenate kinase-associated neurodegeneration9.9
39acute disseminated encephalomyelitis9.9
40astrocytoma9.9
41complex regional pain syndrome9.9
42guillain-barre syndrome9.9
43learning disability9.9
44myeloid leukemia9.9
45paraplegia9.9
46tetanus9.9
47arachnoid cysts9.9
48pandas9.9
49west nile virus9.9
50head injury9.9

Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to conversion disorder

Symptoms for Conversion Disorder

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Drugs & Therapeutics for Conversion Disorder

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Drug clinical trials:

Search ClinicalTrials for Conversion Disorder

Search NIH Clinical Center for Conversion Disorder

Genetic Tests for Conversion Disorder

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Anatomical Context for Conversion Disorder

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MalaCards organs/tissues related to Conversion Disorder:

32
Brain, Spinal cord, Cortex, Myeloid, Cingulate cortex

Animal Models for Conversion Disorder or affiliated genes

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MGI Mouse Phenotypes related to Conversion Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.7BDNF, GAD1
2MP:00053868.5BDNF, GAD1, COMT

Publications for Conversion Disorder

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Articles related to Conversion Disorder:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
The relationship between temperament and character in conversion disorder and comorbid depression. (23218680)
2013
2
Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. (23626829)
2013
3
Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder. (23613193)
2013
4
Neuropsychological function and memory suppression in conversion disorder. (23582098)
2013
5
Action-effect binding is decreased in motor conversion disorder: implications for sense of agency. (23494975)
2013
6
Conversion disorder. (23622298)
2013
7
The chiropractic care of a child with extremity tremors concomitant with a medical diagnosis of conversion disorder. (22500845)
2012
8
The neural circuitry of conversion disorder and its recovery. (21859163)
2012
9
Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder. (21935985)
2011
10
Conversion disorder as initial diagnosis in pantothenate kinase associated neurodegeneration. (20717690)
2011
11
Treatment of conversion disorder in the 21st century: have we moved beyond the couch? (21468672)
2011
12
Conversion disorder: understanding the pathogenic links between emotion and motor systems in the brain. (20418528)
2010
13
Valproate in conversion disorder: a case report. (20671980)
2010
14
Abreaction for conversion disorder: systematic review with meta-analysis. (20679259)
2010
15
Increased activation in cingulate cortex in conversion disorder: what does it mean? (19733363)
2010
16
The involuntary nature of conversion disorder. (20083798)
2010
17
The neuropsychiatry of conversion disorder. (18382227)
2008
18
Physical therapy management for conversion disorder: case series. (17419887)
2007
19
Conversion disorder in Australian pediatric practice. (17195731)
2007
20
Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey. (17639308)
2007
21
Clinical profile and outcome of conversion disorder in children in a tertiary hospital of north India. (17459885)
2007
22
Conversion disorder: towards a neurobiological understanding. (19412442)
2006
23
Volumetric investigation of brain regions in patients with conversion disorder. (16600450)
2006
24
Temperamental traits associated with conversion disorder. (17079833)
2006
25
Healing the disembodied mind: contemporary models of conversion disorder. (15804930)
2005
26
Urinary retention, erectile dysfunction and penile anaesthesia after circumcision: a mixed dissociative (conversion) disorder. (16307335)
2005
27
Progress in understanding conversion disorder. (18568070)
2005
28
Case report: physiotherapy strategies for a patient with conversion disorder presenting abnormal gait. (16245757)
2005
29
Conversion disorder in a child presenting as sudden sensorineural hearing loss. (15964081)
2005
30
Sociodemographic and clinical characteristics of patients with conversion disorder in Eastern Turkey. (12563551)
2003
31
A randomized controlled clinical trial of a hypnosis-based treatment for patients with conversion disorder, motor type. (12825917)
2003
32
Deception or misinterpretation in case of a conversion disorder? (14630461)
2003
33
Conversion disorder in children and adolescents: a 4-year follow-up study. (11943237)
2002
34
Pseudodystrophy. A conversion disorder mimicking reflex sympathetic dystrophy. (12415933)
2002
35
Conversion disorder: difficulties in diagnosis using DSM-IV/ICD-10. (11759495)
2001
36
Reevaluation of serum cortisol in conversion disorder with seizure (pseudoseizure) (10749955)
2000
37
Polysymptomatic conversion disorder in childhood and adolescence in Japan. Early manifestation or incomplete form of somatization disorder? (10773777)
2000
38
Organic syndromes diagnosed as conversion disorder: identification and frequency in a study of 85 patients. (11053598)
2000
39
Conversion disorder and multiple chemical sensitivity: a comparative study of psychological defense strategies. (11153853)
2000
40
Distinguishing conversion disorder from neurologic impairment. (9140848)
1997
41
Conversion disorder presenting as a head injury. (9248922)
1997
42
Conversion disorder after maxillofacial trauma and surgery. (8727582)
1996
43
Hoarseness after cardiac operations: vocal cord paralysis or a conversion disorder? (8823130)
1996
44
Conversion disorder presenting as gait disturbance in an adolescent. (7647948)
1995
45
Diagnostic issues for conversion disorder. (1427673)
1992
46
Hyperemesis gravidarum as conversion disorder. (2230751)
1990
47
Visual conversion disorder: a case analysis of the influence of visual information. (2768670)
1989
48
Conversion disorder (DSM-III 300.11): symptomatology and course in childhood and adolescence. (2721533)
1989
49
The use of contingent reinforcement in the treatment of a conversion disorder: a multiple baseline study. (4086655)
1985
50
Factitious illness v conversion disorder. (6854863)
1983

Variations for Conversion Disorder

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Expression for genes affiliated with Conversion Disorder

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Expression patterns in normal tissues for genes affiliated with Conversion Disorder

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Pathways for genes affiliated with Conversion Disorder

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Compounds for genes affiliated with Conversion Disorder

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Compounds related to Conversion Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pyridoxal 5-phosphate449.7COMT, GAD1
2dopac449.6BDNF, COMT
3mhpg449.6COMT, BDNF
4antipsychotics509.6BDNF, COMT
5maoa449.6BDNF, COMT
6homovanillic acid44 2410.6BDNF, COMT
7pramipexole44 28 50 1112.5BDNF, COMT
8fluvoxamine44 50 1111.5BDNF, COMT
9venlafaxine44 50 24 1112.5BDNF, COMT
10selegiline44 1110.5COMT, BDNF
11heroin44 50 1111.5COMT, BDNF
12paroxetine44 50 28 1112.5BDNF, COMT
13methamphetamine44 50 1111.5COMT, BDNF
14risperidone44 50 28 61 24 1114.5BDNF, COMT
156-hydroxydopamine449.5BDNF, COMT
16olanzapine44 50 28 24 1113.5COMT, BDNF
17bicuculline44 2810.5BDNF, GAD1
18quinolinic acid44 2410.4BDNF, GAD1
19catecholamine449.4COMT, BDNF
20muscimol44 61 2811.4GAD1, BDNF
21valproate449.4GAD1, BDNF
22cocaine44 1110.4COMT, BDNF
23streptozotocin449.4GAD1, BDNF
24valine449.4BDNF, COMT
25tetrodotoxin44 61 2811.4BDNF, GAD1
26haloperidol44 50 28 2 1113.3BDNF, GAD1
27kainate44 2810.3GAD1, BDNF
28valproic acid44 50 24 1112.3BDNF, GAD1
29gold449.3BDNF, GAD1
30epinephrine44 24 1111.3BDNF, COMT
31bromodeoxyuridine449.3BDNF, GAD1
32ascorbic acid44 2410.2BDNF, COMT
33gnrh449.2BDNF, GAD1
34gaba449.2GAD1, BDNF
35tamoxifen44 50 28 1112.2BDNF, COMT
36ethanol44 50 24 1112.1COMT, BDNF
37norepinephrine44 24 1111.0BDNF, COMT
38potassium44 24 1111.0BDNF, GAD1
39mptp449.0BDNF, GAD1, COMT
40levodopa44 1110.0BDNF, GAD1, COMT
41clozapine44 28 50 1112.0COMT, GAD1, BDNF
42choline44 24 1111.0BDNF, GAD1, COMT
43methionine449.0COMT, GAD1, BDNF
44nmda44 289.9BDNF, GAD1, COMT
45estradiol44 24 1110.9COMT, GAD1, BDNF
46proline448.9COMT, GAD1, BDNF
47hydrogen44 249.9COMT, GAD1, BDNF
48dopamine44 28 24 1111.9COMT, GAD1, BDNF
49glutamate448.8BDNF, GAD1, COMT
50acetylcholine44 50 28 24 1112.7BDNF, GAD1

GO Terms for genes affiliated with Conversion Disorder

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Biological processes related to Conversion Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:0072689.3GAD1, COMT
2neurotransmitter biosynthetic processGO:0421369.2GAD1, COMT
3response to drugGO:0424939.0GAD1, COMT

Products for genes affiliated with Conversion Disorder

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Sources for Conversion Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet