FND
MCID: CNV002
MIFTS: 49

Conversion Disorder (FND) malady

Rare diseases, Mental diseases, Neuronal diseases categories

Summaries for Conversion Disorder

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained. symptoms may occur because of emotional distress or psychological problems. theyĀ usually begin suddenly after a stressful experience. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 5/21/2014

MalaCards: Conversion Disorder, also known as hysterical neurosis, conversion type, is related to anorexia nervosa and anxiety disorder. An important gene associated with Conversion Disorder is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. The compounds pyridoxal 5-phosphate and dopac have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and myeloid, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Disease Ontology:9 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia:66 A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness,... more...

Aliases & Classifications for Conversion Disorder

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

conversion disorder 9 44 63
hysterical neurosis, conversion type 9
functional neurological disorder 44
conversion hysterical neurosis 9
functional movement disorder 44
frontonasal dysplasia 63
conversion hysteria 9
reaction 9
fnd 44


External Ids:

Disease Ontology9 DOID:1768
ICD9CM28 300.11
MeSH36 D003291
ICD1026 F43.9

Related Diseases for Conversion Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Conversion Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa30.2BDNF, COMT
2anxiety disorder29.8BDNF, GAD1, COMT
3multiple sclerosis29.8BDNF, GAD1, COMT
4mental retardation29.8BDNF, COMT
5frontonasal dysplasia10.5
6dissociative disorder10.3
7dystonia10.2
8polyradiculoneuropathy10.2
9torsion dystonia10.2
10reflex sympathetic dystrophy10.2
11alexithymia10.1
12hemiplegia10.1
13follicular lymphoma10.0
14frontonasal dysplasia acromelic10.0
15type 1 diabetes mellitus10.0GAD1, COMT
16bulimia nervosa10.0COMT, BDNF
17obsessive-compulsive disorder10.0BDNF, COMT
18schizoaffective disorder10.0COMT, BDNF
19eating disorder10.0BDNF, COMT
20attention deficit hyperactivity disorder10.0COMT, BDNF
21endogenous depression10.0BDNF, GAD1
22status epilepticus10.0GAD1, BDNF
23parkinson's disease10.0BDNF, COMT
24temporal lobe epilepsy10.0GAD1, BDNF
25dementia10.0BDNF, COMT
26autistic disorder10.0BDNF, GAD1
27herpes simplex10.0BDNF, GAD1
28hyperglycemia10.0GAD1, BDNF
29ischemia10.0BDNF, GAD1
30epilepsy syndrome9.9BDNF, GAD1
31psychotic disorder9.9BDNF, GAD1, COMT
32mood disorder9.9COMT, GAD1, BDNF
33hypoglycemia9.9BDNF, GAD1, COMT
34bipolar disorder9.9BDNF, GAD1, COMT
35schizophrenia9.9BDNF, GAD1, COMT
36acute disseminated encephalomyelitis9.9
37locked-in syndrome9.9
38addison's disease9.9
39multiple chemical sensitivity9.9
40sensorineural hearing loss9.9
41epidural abscess9.9
42hypochondriasis9.9
43cerebritis9.9
44acute myeloid leukemia9.9
45dissociative amnesia9.9
46arachnoiditis9.9
47somatization disorder9.9
48spinal cord astrocytoma9.9
49pantothenate kinase-associated neurodegeneration9.9
50astrocytoma9.9

Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to conversion disorder

Symptoms for Conversion Disorder

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Drugs & Therapeutics for Conversion Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Conversion Disorder

Drug clinical trials:

Search ClinicalTrials for Conversion Disorder

Search NIH Clinical Center for Conversion Disorder

Search CenterWatch for Conversion Disorder

Genetic Tests for Conversion Disorder

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Anatomical Context for Conversion Disorder

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Sources:
34MalaCards
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MalaCards organs/tissues related to Conversion Disorder:

34
Brain, Spinal cord, Myeloid, Cortex, Cingulate cortex

Animal Models for Conversion Disorder or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Conversion Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.7BDNF, GAD1
2MP:00053868.5BDNF, GAD1, COMT

Publications for Conversion Disorder

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Sources:
53PubMed
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Articles related to Conversion Disorder:

(show top 50)    (show all 248)
idTitleAuthorsYear
1
The relationship between temperament and character in conversion disorder and comorbid depression. (23218680)
2013
2
Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. (23626829)
2013
3
Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder. (23613193)
2013
4
Neuropsychological function and memory suppression in conversion disorder. (23582098)
2013
5
Action-effect binding is decreased in motor conversion disorder: implications for sense of agency. (23494975)
2013
6
Conversion disorder. (23622298)
2013
7
The chiropractic care of a child with extremity tremors concomitant with a medical diagnosis of conversion disorder. (22500845)
2012
8
The neural circuitry of conversion disorder and its recovery. (21859163)
2012
9
Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder. (21935985)
2011
10
Conversion disorder as initial diagnosis in pantothenate kinase associated neurodegeneration. (20717690)
2011
11
Treatment of conversion disorder in the 21st century: have we moved beyond the couch? (21468672)
2011
12
Conversion disorder: understanding the pathogenic links between emotion and motor systems in the brain. (20418528)
2010
13
Valproate in conversion disorder: a case report. (20671980)
2010
14
Abreaction for conversion disorder: systematic review with meta-analysis. (20679259)
2010
15
Increased activation in cingulate cortex in conversion disorder: what does it mean? (19733363)
2010
16
The involuntary nature of conversion disorder. (20083798)
2010
17
The neuropsychiatry of conversion disorder. (18382227)
2008
18
Physical therapy management for conversion disorder: case series. (17419887)
2007
19
Conversion disorder in Australian pediatric practice. (17195731)
2007
20
Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey. (17639308)
2007
21
Clinical profile and outcome of conversion disorder in children in a tertiary hospital of north India. (17459885)
2007
22
Conversion disorder: towards a neurobiological understanding. (19412442)
2006
23
Volumetric investigation of brain regions in patients with conversion disorder. (16600450)
2006
24
Temperamental traits associated with conversion disorder. (17079833)
2006
25
Healing the disembodied mind: contemporary models of conversion disorder. (15804930)
2005
26
Urinary retention, erectile dysfunction and penile anaesthesia after circumcision: a mixed dissociative (conversion) disorder. (16307335)
2005
27
Progress in understanding conversion disorder. (18568070)
2005
28
Case report: physiotherapy strategies for a patient with conversion disorder presenting abnormal gait. (16245757)
2005
29
Conversion disorder in a child presenting as sudden sensorineural hearing loss. (15964081)
2005
30
Sociodemographic and clinical characteristics of patients with conversion disorder in Eastern Turkey. (12563551)
2003
31
A randomized controlled clinical trial of a hypnosis-based treatment for patients with conversion disorder, motor type. (12825917)
2003
32
Deception or misinterpretation in case of a conversion disorder? (14630461)
2003
33
Conversion disorder in children and adolescents: a 4-year follow-up study. (11943237)
2002
34
Pseudodystrophy. A conversion disorder mimicking reflex sympathetic dystrophy. (12415933)
2002
35
Conversion disorder: difficulties in diagnosis using DSM-IV/ICD-10. (11759495)
2001
36
Reevaluation of serum cortisol in conversion disorder with seizure (pseudoseizure) (10749955)
2000
37
Polysymptomatic conversion disorder in childhood and adolescence in Japan. Early manifestation or incomplete form of somatization disorder? (10773777)
2000
38
Organic syndromes diagnosed as conversion disorder: identification and frequency in a study of 85 patients. (11053598)
2000
39
Conversion disorder and multiple chemical sensitivity: a comparative study of psychological defense strategies. (11153853)
2000
40
Distinguishing conversion disorder from neurologic impairment. (9140848)
1997
41
Conversion disorder presenting as a head injury. (9248922)
1997
42
Conversion disorder after maxillofacial trauma and surgery. (8727582)
1996
43
Hoarseness after cardiac operations: vocal cord paralysis or a conversion disorder? (8823130)
1996
44
Conversion disorder presenting as gait disturbance in an adolescent. (7647948)
1995
45
Diagnostic issues for conversion disorder. (1427673)
1992
46
Hyperemesis gravidarum as conversion disorder. (2230751)
1990
47
Visual conversion disorder: a case analysis of the influence of visual information. (2768670)
1989
48
Conversion disorder (DSM-III 300.11): symptomatology and course in childhood and adolescence. (2721533)
1989
49
The use of contingent reinforcement in the treatment of a conversion disorder: a multiple baseline study. (4086655)
1985
50
Factitious illness v conversion disorder. (6854863)
1983

Variations for Conversion Disorder

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Conversion Disorder:

1
id Gene Name Type Significance SNP ID Assembly Location
1ALX3NM_006492.2(ALX3): c.608A> G (p.Asn203Ser)single nucleotide variantPathogenicrs121908166GRCh37Chr 1, 110604172: 110604172
2ALX3NM_006492.2(ALX3): c.502C> G (p.Leu168Val)single nucleotide variantPathogenicrs121908167GRCh37Chr 1, 110607301: 110607301
3ALX3NM_006492.2(ALX3): c.547C> T (p.Arg183Trp)single nucleotide variantPathogenicrs121908168GRCh37Chr 1, 110607256: 110607256
4ALX3NM_006492.2(ALX3): c.543T> A (p.Tyr181Ter)single nucleotide variantPathogenicrs121908169GRCh37Chr 1, 110607260: 110607260
5ALX3NM_006492.2(ALX3): c.578_581delCTGA (p.Thr193Argfs)deletionPathogenicrs387906319GRCh37Chr 1, 110607222: 110607225
6ALX3NM_006492.2(ALX3): c.586C> T (p.Arg196Trp)single nucleotide variantPathogenicrs121908170GRCh37Chr 1, 110607217: 110607217

Expression for genes affiliated with Conversion Disorder

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conversion Disorder

Search GEO for disease gene expression data for Conversion Disorder.

Pathways for genes affiliated with Conversion Disorder

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database
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Compounds for genes affiliated with Conversion Disorder

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Sources:
46Novoseek, 52PharmGKB, 25HMDB, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 3BitterDB
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Compounds related to Conversion Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pyridoxal 5-phosphate469.7COMT, GAD1
2dopac469.6BDNF, COMT
3mhpg469.6COMT, BDNF
4antipsychotics529.6BDNF, COMT
5maoa469.6BDNF, COMT
6homovanillic acid46 2510.6BDNF, COMT
7pramipexole46 30 52 1212.5BDNF, COMT
8fluvoxamine46 52 1211.5BDNF, COMT
9venlafaxine46 52 25 1212.5BDNF, COMT
10selegiline46 1210.5COMT, BDNF
11heroin46 52 1211.5COMT, BDNF
12paroxetine46 52 30 1212.5BDNF, COMT
13methamphetamine46 52 1211.5COMT, BDNF
14risperidone46 52 30 62 25 1214.5BDNF, COMT
156-hydroxydopamine469.5BDNF, COMT
16olanzapine46 52 30 25 1213.5COMT, BDNF
17bicuculline46 3010.5BDNF, GAD1
18quinolinic acid46 2510.4BDNF, GAD1
19catecholamine469.4COMT, BDNF
20muscimol46 62 3011.4GAD1, BDNF
21valproate469.4GAD1, BDNF
22cocaine46 1210.4COMT, BDNF
23streptozotocin469.4GAD1, BDNF
24valine469.4BDNF, COMT
25tetrodotoxin46 62 3011.4BDNF, GAD1
26haloperidol46 52 30 3 1213.3BDNF, GAD1
27kainate46 3010.3GAD1, BDNF
28valproic acid46 52 25 1212.3BDNF, GAD1
29gold469.3BDNF, GAD1
30epinephrine46 25 1211.3BDNF, COMT
31bromodeoxyuridine469.3BDNF, GAD1
32ascorbic acid46 2510.2BDNF, COMT
33gnrh469.2BDNF, GAD1
34gaba469.2GAD1, BDNF
35tamoxifen46 52 30 1212.2BDNF, COMT
36ethanol46 52 25 1212.1COMT, BDNF
37norepinephrine46 25 1211.0BDNF, COMT
38potassium46 25 1211.0BDNF, GAD1
39mptp469.0BDNF, GAD1, COMT
40levodopa46 1210.0BDNF, GAD1, COMT
41clozapine46 30 52 1212.0COMT, GAD1, BDNF
42choline46 25 1211.0BDNF, GAD1, COMT
43methionine469.0COMT, GAD1, BDNF
44nmda46 309.9BDNF, GAD1, COMT
45estradiol46 25 1210.9COMT, GAD1, BDNF
46proline468.9COMT, GAD1, BDNF
47hydrogen46 259.9COMT, GAD1, BDNF
48dopamine46 30 25 1211.9COMT, GAD1, BDNF
49glutamate468.8BDNF, GAD1, COMT
50acetylcholine46 52 30 25 1212.7BDNF, GAD1

GO Terms for genes affiliated with Conversion Disorder

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17Gene Ontology
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Biological processes related to Conversion Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:0072689.3GAD1, COMT
2neurotransmitter biosynthetic processGO:0421369.2GAD1, COMT
3response to drugGO:0424939.0GAD1, COMT

Products for genes affiliated with Conversion Disorder

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Sources for Conversion Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet