FND
MCID: CNV002
MIFTS: 50

Conversion Disorder (FND) malady

Neuronal diseases category

Summaries for Conversion Disorder

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained. symptoms may occur because of emotional distress or psychological problems. they usually begin suddenly after a stressful experience. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 9/20/2010

MalaCards: Conversion Disorder, also known as hysterical neurosis, conversion type, is related to herpes simplex and neuroblastoma. An important gene associated with Conversion Disorder is BDNF (brain-derived neurotrophic factor). The compounds bicuculline and muscimol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone marrow, and related mouse phenotype taste/olfaction.

Disease Ontology:8 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia:63 A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness,... more...

Aliases & Classifications for Conversion Disorder

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

conversion disorder 8 42 60
hysterical neurosis, conversion type 8
functional neurological disorder 42
conversion hysterical neurosis 8
functional movement disorder 42
frontonasal dysplasia 60
conversion hysteria 8
reaction 8
fnd 42


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Disease Ontology8 DOID:1768
MeSH34 D003291
ICD9CM27 300.11
ICD1025 F43.9

Related Diseases for Conversion Disorder

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to conversion disorder

Clinical Features for Conversion Disorder

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Drugs & Therapeutics for Conversion Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Conversion Disorder

Search NIH Clinical Center for Conversion Disorder

Search CenterWatch for Conversion Disorder

Genetic Tests for Conversion Disorder

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Anatomical Context for Conversion Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Conversion Disorder:

32
Brain, Spinal cord, Bone marrow, Bone, Cortex, Myeloid, T cells, Cingulate cortex

Animal Models for Conversion Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Conversion Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.0GAD1, BDNF

Publications for Conversion Disorder

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50PubMed
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Articles related to Conversion Disorder:

(show top 50)    (show all 268)
idTitleAuthorsYear
1
Risk factors for conversion from unipolar psychotic depression to bipolar disorder. (24215495)
2013
2
Action-effect binding is decreased in motor conversion disorder: implications for sense of agency. (23494975)
2013
3
Conversion disorder. (23622298)
2013
4
Role of sexual abuse in development of conversion disorder: case report. (22428482)
2012
5
Aphonia induced by conversion disorder during a Cesarean section. (23026175)
2012
6
Stroke mimic: an interesting case of repetitive conversion disorder. (23203184)
2012
7
Conversion disorder: a problematic diagnosis. (21036784)
2011
8
Conversion disorder: advances in our understanding. (21502352)
2011
9
Conversion disorder: current problems and potential solutions for DSM-5. (22118377)
2011
10
Neurologists' understanding and management of conversion disorder. (21325661)
2011
11
The involuntary nature of conversion disorder. (20083798)
2010
12
Issues for DSM-5: Conversion disorder. (20516161)
2010
13
Inherited disorders in the conversion of methionine to homocysteine. (19585268)
2009
14
Treatment of conversion disorder. A clinical and holistic approach. (19681521)
2009
15
Sex distribution and psychiatric features of child and adolescent conversion disorder across 2 decades. (19762315)
2009
16
PANDAS and paroxysms: a case of conversion disorder? (18294094)
2008
17
Conversion disorder mimicking serotonin syndrome in an adolescent taking sertraline. (18512641)
2008
18
Compulsive symptoms in dissociative (conversion) disorder. (20844654)
2006
19
Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. (16344985)
2006
20
Healing the disembodied mind: contemporary models of conversion disorder. (15804930)
2005
21
Urinary retention, erectile dysfunction and penile anaesthesia after circumcision: a mixed dissociative (conversion) disorder. (16307335)
2005
22
Conversion disorder: four case reports concerning motor disorder symptoms. (15928898)
2005
23
Conversion disorder. (16201035)
2005
24
Psychosocial interventions for conversion disorder. (16235402)
2005
25
The impact of early trauma and recent life-events on symptom severity in patients with conversion disorder. (16082294)
2005
26
Spinal cord astrocytoma mistaken for conversion disorder. (15774957)
2005
27
Conversion disorder presenting as pseudohydrophobia. (15623923)
2004
28
Pseudolabor: A New Conversion Disorder Subtype? A Case Presentation and Literature Review. (15254598)
2004
29
Conversion disorder mimicking Dejerine-Roussy syndrome (thalamic stroke) after spinal cord stimulation. (15029553)
2004
30
Abnormal somatosensory evoked potentials in two patients with conversion disorder. (15009831)
2004
31
Trauma and dissociation in conversion disorder and chronic pelvic pain. (15825581)
2004
32
Childhood trauma, dissociation, and psychiatric comorbidity in patients with conversion disorder. (15569899)
2004
33
Childhood abuse in patients with conversion disorder. (12411227)
2002
34
A 9-year-old with conversion disorder, successfully treated with psychoanalysis. (12088560)
2002
35
Polysymptomatic conversion disorder in childhood and adolescence in Japan. Early manifestation or incomplete form of somatization disorder? (10773777)
2000
36
Conversion disorder and multiple chemical sensitivity: a comparative study of psychological defense strategies. (11153853)
2000
37
Suspected conversion disorder: foreseeable risks and avoidable errors. (11073477)
2000
38
Cerebral blood flow changes in patients with conversion disorder. (9849725)
1998
39
Lower extremity paralysis after operative laparoscopy from conversion disorder. A case report. (9777625)
1998
40
Conversion disorder presenting as a head injury. (9248922)
1997
41
Behavioral treatment of conversion disorder in adolescence. A case example of Globus Hystericus. (9086868)
1997
42
Is conversion disorder biologically related with depression?: a DST study. (8837984)
1996
43
Conversion disorder with pseudohallucinations. (8633703)
1996
44
Reflex sympathetic dystrophy/conversion disorder. (8969114)
1996
45
Emergency department presentation of patients with conversion disorder. (7621217)
1995
46
The amytal interview in the treatment of conversion disorder: three case reports. (20058436)
1994
47
Dissociative disorder, conversion disorder and the use of abreaction in a 22 year old male. (6955663)
1982
48
The "on-off" syndrome presenting as a conversion disorder. (7313061)
1981
49
Practical psychiatry in medicine. Part 13: conversion disorders and hypochondriasis. (702076)
1978
50
De novo appearance of the ph-1 chromosome in a previously monosomic bone marrow (45,XX,-6): conversion of a myeloproliferative disorder to acute myelogenous leukemia. (1054612)
1975

Genetic Variations for Conversion Disorder

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Expression for genes affiliated with Conversion Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conversion Disorder

Search GEO for disease gene expression data for Conversion Disorder.

Pathways for genes affiliated with Conversion Disorder

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Compounds for genes affiliated with Conversion Disorder

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Conversion Disorder according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1bicuculline44 2811.1GAD1
2muscimol44 59 2812.0GAD1
3dopac449.7BDNF, COMT
4mhpg449.7COMT, BDNF
5maoa449.7COMT, BDNF
6homovanillic acid44 2410.7BDNF, COMT
7pramipexole44 49 28 1112.7COMT, BDNF
8selegiline44 1110.7COMT, BDNF
9paroxetine44 49 28 1112.7BDNF, COMT
10risperidone28 44 49 59 11 2414.7BDNF, COMT
11methamphetamine44 49 1111.7COMT, BDNF
126-hydroxydopamine449.6BDNF, COMT
13olanzapine49 44 28 11 2413.6BDNF, COMT
14catecholamine449.6COMT, BDNF
15cocaine44 1110.5BDNF, COMT
16pyridoxal 5-phosphate449.5COMT, GAD1
17quinolinic acid44 2410.4GAD1, BDNF
18valine449.4BDNF, COMT
19valproate449.4BDNF, GAD1
20streptozotocin449.3BDNF, GAD1
21ascorbic acid44 2410.3BDNF, COMT
22tetrodotoxin44 59 2811.3BDNF, GAD1
23haloperidol44 28 2 49 1113.3BDNF, GAD1
24valproic acid44 49 11 2412.3BDNF, GAD1
25kainate44 2810.2BDNF, GAD1
26gold449.2GAD1, BDNF
27bromodeoxyuridine449.1BDNF, GAD1
28gnrh449.0GAD1, BDNF
29epinephrine44 11 2411.0BDNF, COMT
30mptp448.9GAD1, BDNF, COMT
31levodopa44 119.9COMT, BDNF, GAD1
32clozapine44 28 49 1111.9GAD1, BDNF, COMT
33gaba448.9BDNF, GAD1
34choline44 11 2410.9COMT, BDNF, GAD1
35methionine448.9GAD1, BDNF, COMT
36nmda44 289.9GAD1, BDNF, COMT
37estradiol44 11 2410.9GAD1, BDNF, COMT
38proline448.9COMT, BDNF, GAD1
39hydrogen44 249.9GAD1, BDNF, COMT
40dopamine44 28 11 2411.9COMT, BDNF, GAD1
41glutamate448.8GAD1, BDNF, COMT

GO Terms for genes affiliated with Conversion Disorder

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16Gene Ontology
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Biological processes related to Conversion Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424939.1GAD1, COMT
2neurotransmitter biosynthetic processGO:0421368.8GAD1, COMT

Products for genes affiliated with Conversion Disorder

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  • Antibodies
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  • Antibodies

Sources for Conversion Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet