FND
MCID: CNV002
MIFTS: 48

Conversion Disorder (FND) malady

Rare diseases, Mental diseases, Neuronal diseases categories

Summaries for Conversion Disorder

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NIH Rare Diseases:42 Conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained. symptoms may occur because of emotional distress or psychological problems. they usually begin suddenly after a stressful experience. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 5/21/2014

MalaCards based summary: Conversion Disorder, also known as conversion hysterical neurosis, is related to anorexia nervosa and anxiety disorder. An important gene associated with Conversion Disorder is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. The compounds pyridoxal 5-phosphate and dopac have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Disease Ontology:9 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia:64 A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness,... more...

Aliases & Classifications for Conversion Disorder

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Conversion Disorder, Aliases & Descriptions:

Name: Conversion Disorder 9 42 61
Conversion Hysterical Neurosis 9 61
Hysterical Neurosis, Conversion Type 9
Functional Neurological Disorder 42
Functional Movement Disorder 42
 
Frontonasal Dysplasia 61
Conversion Hysteria 9
Reaction 9
Fnd 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology9 DOID:1768
MeSH34 D003291
ICD9CM28 300.11
ICD1026 F43.9

Related Diseases for Conversion Disorder

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Diseases related to Conversion Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa30.2BDNF, COMT
2anxiety disorder29.6BDNF, GAD1, COMT
3multiple sclerosis29.6BDNF, GAD1, COMT
4mental retardation29.5BDNF, COMT
5frontonasal dysplasia10.5
6dissociative disorder10.3
7dystonia10.2
8polyradiculoneuropathy10.2
9torsion dystonia10.2
10reflex sympathetic dystrophy10.2
11alexithymia10.2
12hemiplegia10.1
13follicular lymphoma10.0
14type 1 diabetes mellitus10.0GAD1, COMT
15bulimia nervosa10.0COMT, BDNF
16obsessive-compulsive disorder10.0BDNF, COMT
17schizoaffective disorder10.0COMT, BDNF
18eating disorder10.0BDNF, COMT
19attention deficit hyperactivity disorder10.0COMT, BDNF
20endogenous depression10.0BDNF, GAD1
21status epilepticus10.0GAD1, BDNF
22parkinson's disease10.0BDNF, COMT
23temporal lobe epilepsy9.9GAD1, BDNF
24acute myeloid leukemia9.9
25brain injury9.9
26leukemia9.9
27addison's disease9.9
28somatization disorder9.9
29locked-in syndrome9.9
30multiple chemical sensitivity9.9
31sensorineural hearing loss9.9
32hypochondriasis9.9
33arachnoiditis9.9
34spinal cord astrocytoma9.9
35epidural abscess9.9
36cerebritis9.9
37dissociative amnesia9.9
38pantothenate kinase-associated neurodegeneration9.9
39acute disseminated encephalomyelitis9.9
40astrocytoma9.9
41complex regional pain syndrome9.9
42guillain-barre syndrome9.9
43learning disability9.9
44myeloid leukemia9.9
45paraplegia9.9
46tetanus9.9
47arachnoid cysts9.9
48pandas9.9
49west nile virus9.9
50head injury9.9

Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to conversion disorder

Symptoms for Conversion Disorder

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Drugs & Therapeutics for Conversion Disorder

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Drug clinical trials:

Search ClinicalTrials for Conversion Disorder

Search NIH Clinical Center for Conversion Disorder

Genetic Tests for Conversion Disorder

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Anatomical Context for Conversion Disorder

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MalaCards organs/tissues related to Conversion Disorder:

32
Brain, Spinal cord, Cortex, Myeloid, Cingulate cortex

Animal Models for Conversion Disorder or affiliated genes

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MGI Mouse Phenotypes related to Conversion Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.7BDNF, GAD1
2MP:00053868.5BDNF, GAD1, COMT

Publications for Conversion Disorder

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Articles related to Conversion Disorder:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
The relationship between temperament and character in conversion disorder and comorbid depression. (23218680)
2013
2
Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. (23626829)
2013
3
Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder. (23613193)
2013
4
Neuropsychological function and memory suppression in conversion disorder. (23582098)
2013
5
Action-effect binding is decreased in motor conversion disorder: implications for sense of agency. (23494975)
2013
6
Conversion disorder. (23622298)
2013
7
The chiropractic care of a child with extremity tremors concomitant with a medical diagnosis of conversion disorder. (22500845)
2012
8
The neural circuitry of conversion disorder and its recovery. (21859163)
2012
9
Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder. (21935985)
2011
10
Conversion disorder as initial diagnosis in pantothenate kinase associated neurodegeneration. (20717690)
2011
11
Treatment of conversion disorder in the 21st century: have we moved beyond the couch? (21468672)
2011
12
Conversion disorder: understanding the pathogenic links between emotion and motor systems in the brain. (20418528)
2010
13
Valproate in conversion disorder: a case report. (20671980)
2010
14
Abreaction for conversion disorder: systematic review with meta-analysis. (20679259)
2010
15
Increased activation in cingulate cortex in conversion disorder: what does it mean? (19733363)
2010
16
The involuntary nature of conversion disorder. (20083798)
2010
17
The neuropsychiatry of conversion disorder. (18382227)
2008
18
Physical therapy management for conversion disorder: case series. (17419887)
2007
19
Conversion disorder in Australian pediatric practice. (17195731)
2007
20
Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey. (17639308)
2007
21
Clinical profile and outcome of conversion disorder in children in a tertiary hospital of north India. (17459885)
2007
22
Conversion disorder: towards a neurobiological understanding. (19412442)
2006
23
Volumetric investigation of brain regions in patients with conversion disorder. (16600450)
2006
24
Temperamental traits associated with conversion disorder. (17079833)
2006
25
Healing the disembodied mind: contemporary models of conversion disorder. (15804930)
2005
26
Urinary retention, erectile dysfunction and penile anaesthesia after circumcision: a mixed dissociative (conversion) disorder. (16307335)
2005
27
Progress in understanding conversion disorder. (18568070)
2005
28
Case report: physiotherapy strategies for a patient with conversion disorder presenting abnormal gait. (16245757)
2005
29
Conversion disorder in a child presenting as sudden sensorineural hearing loss. (15964081)
2005
30
Sociodemographic and clinical characteristics of patients with conversion disorder in Eastern Turkey. (12563551)
2003
31
A randomized controlled clinical trial of a hypnosis-based treatment for patients with conversion disorder, motor type. (12825917)
2003
32
Deception or misinterpretation in case of a conversion disorder? (14630461)
2003
33
Conversion disorder in children and adolescents: a 4-year follow-up study. (11943237)
2002
34
Pseudodystrophy. A conversion disorder mimicking reflex sympathetic dystrophy. (12415933)
2002
35
Conversion disorder: difficulties in diagnosis using DSM-IV/ICD-10. (11759495)
2001
36
Reevaluation of serum cortisol in conversion disorder with seizure (pseudoseizure) (10749955)
2000
37
Polysymptomatic conversion disorder in childhood and adolescence in Japan. Early manifestation or incomplete form of somatization disorder? (10773777)
2000
38
Organic syndromes diagnosed as conversion disorder: identification and frequency in a study of 85 patients. (11053598)
2000
39
Conversion disorder and multiple chemical sensitivity: a comparative study of psychological defense strategies. (11153853)
2000
40
Distinguishing conversion disorder from neurologic impairment. (9140848)
1997
41
Conversion disorder presenting as a head injury. (9248922)
1997
42
Conversion disorder after maxillofacial trauma and surgery. (8727582)
1996
43
Hoarseness after cardiac operations: vocal cord paralysis or a conversion disorder? (8823130)
1996
44
Conversion disorder presenting as gait disturbance in an adolescent. (7647948)
1995
45
Diagnostic issues for conversion disorder. (1427673)
1992
46
Hyperemesis gravidarum as conversion disorder. (2230751)
1990
47
Visual conversion disorder: a case analysis of the influence of visual information. (2768670)
1989
48
Conversion disorder (DSM-III 300.11): symptomatology and course in childhood and adolescence. (2721533)
1989
49
The use of contingent reinforcement in the treatment of a conversion disorder: a multiple baseline study. (4086655)
1985
50
Factitious illness v conversion disorder. (6854863)
1983

Variations for Conversion Disorder

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Expression for genes affiliated with Conversion Disorder

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Expression patterns in normal tissues for genes affiliated with Conversion Disorder

Search GEO for disease gene expression data for Conversion Disorder.

Pathways for genes affiliated with Conversion Disorder

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Compounds for genes affiliated with Conversion Disorder

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Compounds related to Conversion Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pyridoxal 5-phosphate449.7GAD1, COMT
2dopac449.6BDNF, COMT
3mhpg449.6BDNF, COMT
4antipsychotics509.6BDNF, COMT
5maoa449.6BDNF, COMT
6homovanillic acid44 2510.6BDNF, COMT
7pramipexole44 29 50 1212.5COMT, BDNF
8fluvoxamine44 50 1211.5COMT, BDNF
9venlafaxine44 50 25 1212.5COMT, BDNF
10selegiline44 1210.5BDNF, COMT
11heroin44 50 1211.5BDNF, COMT
12paroxetine44 50 29 1212.5COMT, BDNF
13methamphetamine44 50 1211.5COMT, BDNF
14risperidone44 50 29 60 25 1214.5BDNF, COMT
156-hydroxydopamine449.5BDNF, COMT
16olanzapine44 50 29 25 1213.5BDNF, COMT
17bicuculline44 2910.5GAD1, BDNF
18catecholamine449.4BDNF, COMT
19quinolinic acid44 2510.4GAD1, BDNF
20muscimol44 60 2911.4BDNF, GAD1
21valproate449.4BDNF, GAD1
22cocaine44 1210.4COMT, BDNF
23streptozotocin449.4BDNF, GAD1
24valine449.4COMT, BDNF
25tetrodotoxin44 60 2911.4BDNF, GAD1
26haloperidol44 50 29 3 1213.3BDNF, GAD1
27kainate44 2910.3GAD1, BDNF
28valproic acid44 50 25 1212.3GAD1, BDNF
29gold449.3GAD1, BDNF
30epinephrine44 25 1211.3COMT, BDNF
31bromodeoxyuridine449.3GAD1, BDNF
32ascorbic acid44 2510.2BDNF, COMT
33gnrh449.2GAD1, BDNF
34gaba449.2BDNF, GAD1
35tamoxifen44 50 29 1212.2BDNF, COMT
36ethanol44 50 25 1212.1COMT, BDNF
37norepinephrine44 25 1211.0BDNF, COMT
38potassium44 25 1211.0BDNF, GAD1
39mptp449.0COMT, GAD1, BDNF
40levodopa44 1210.0BDNF, GAD1, COMT
41clozapine44 29 50 1212.0BDNF, GAD1, COMT
42choline44 25 1211.0COMT, BDNF, GAD1
43methionine449.0COMT, GAD1, BDNF
44nmda44 299.9COMT, GAD1, BDNF
45estradiol44 25 1210.9BDNF, COMT, GAD1
46proline448.9GAD1, COMT, BDNF
47hydrogen44 259.9BDNF, COMT, GAD1
48dopamine44 29 25 1211.9BDNF, COMT, GAD1
49glutamate448.8GAD1, COMT, BDNF
50acetylcholine44 50 29 25 1212.7BDNF, GAD1

GO Terms for genes affiliated with Conversion Disorder

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Biological processes related to Conversion Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:0072689.3GAD1, COMT
2neurotransmitter biosynthetic processGO:0421369.2GAD1, COMT
3response to drugGO:0424939.0GAD1, COMT

Products for genes affiliated with Conversion Disorder

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Sources for Conversion Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet