MCID: CNV002
MIFTS: 42

Conversion Disorder malady

Rare diseases, Mental diseases, Neuronal diseases categories

Aliases & Classifications for Conversion Disorder

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Aliases & Descriptions for Conversion Disorder:

Name: Conversion Disorder 8 42 61
Hysterical Neurosis, Conversion Type 8
Functional Neurological Disorder 42
Conversion Hysterical Neurosis 8
Functional Movement Disorder 42
 
Dissociative Disorder 61
Frontonasal Dysplasia 61
Conversion Hysteria 8
Reaction 8
Fnd 42


Classifications:



External Ids:

Disease Ontology8 DOID:1768
MeSH33 D003291
ICD9CM27 300.11
ICD1025 F43.9

Summaries for Conversion Disorder

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NIH Rare Diseases:42 Conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained. symptoms may occur because of emotional distress or psychological problems. they usually begin suddenly after a stressful experience. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 5/21/2014

MalaCards based summary: Conversion Disorder, also known as hysterical neurosis, conversion type, is related to anorexia nervosa and anxiety disorder. An important gene associated with Conversion Disorder is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. The compounds pyridoxal 5-phosphate and dopac have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Disease Ontology:8 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia:64 A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness,... more...

Related Diseases for Conversion Disorder

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Diseases related to Conversion Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1anorexia nervosa30.2BDNF, COMT
2anxiety disorder29.6BDNF, GAD1, COMT
3mental retardation29.5BDNF, COMT
4dissociative disorder10.3
5dystonia10.2
6polyradiculoneuropathy10.2
7torsion dystonia10.2
8reflex sympathetic dystrophy10.2
9alexithymia10.2
10hemiplegia10.1
11frontonasal dysplasia 110.1
12follicular lymphoma10.1
13alcohol dependence10.0GAD1, COMT
14diabetes mellitus, insulin-dependent10.0GAD1, COMT
15bulimia nervosa10.0COMT, BDNF
16obsessive-compulsive disorder10.0BDNF, COMT
17schizophrenia10.0COMT, BDNF
18eating disorder10.0BDNF, COMT
19attention deficit-hyperactivity disorder10.0COMT, BDNF
20major depressive disorder and accelerated response to antidepressant drug treatment10.0BDNF, GAD1
21status epilepticus10.0GAD1, BDNF
22parkinson disease, late-onset9.9BDNF, COMT
23west nile virus9.9
24brain injury9.9
25leukemia9.9
26locked-in syndrome9.9
27addison's disease9.9
28multiple chemical sensitivity9.9
29sensorineural hearing loss9.9
30epidural abscess9.9
31hypochondriasis9.9
32cerebritis9.9
33dissociative amnesia9.9
34arachnoiditis9.9
35somatization disorder9.9
36spinal cord astrocytoma9.9
37acute disseminated encephalomyelitis9.9
38astrocytoma9.9
39complex regional pain syndrome9.9
40guillain-barre syndrome9.9
41learning disability9.9
42myeloid leukemia9.9
43paraplegia9.9
44ptosis9.9
45tetanus9.9
46neurologic diseases9.9
47arachnoid cysts9.9
48pandas9.9
49head injury9.9
50tremor9.9

Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to conversion disorder

Symptoms for Conversion Disorder

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Drugs & Therapeutics for Conversion Disorder

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Drug clinical trials:

Search ClinicalTrials for Conversion Disorder

Search NIH Clinical Center for Conversion Disorder

Genetic Tests for Conversion Disorder

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Anatomical Context for Conversion Disorder

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MalaCards organs/tissues related to Conversion Disorder:

31
Brain, Spinal cord, Cortex, Myeloid, Cingulate cortex, Pituitary

Animal Models for Conversion Disorder or affiliated genes

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MGI Mouse Phenotypes related to Conversion Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.7BDNF, GAD1
2MP:00053868.5BDNF, GAD1, COMT

Publications for Conversion Disorder

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Articles related to Conversion Disorder:

(show top 50)    (show all 267)
idTitleAuthorsYear
1
Pituitary volumes are changed in patients with conversion disorder. (25877743)
2015
2
Hospital revisit rate after a diagnosis of conversion disorder. (25855400)
2015
3
Monolimb paralysis after laparoscopic appendectomy due to conversion disorder. (25426280)
2014
4
The relationship between temperament and character in conversion disorder and comorbid depression. (23218680)
2013
5
Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. (23626829)
2013
6
Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder. (23613193)
2013
7
Neuropsychological function and memory suppression in conversion disorder. (23582098)
2013
8
Action-effect binding is decreased in motor conversion disorder: implications for sense of agency. (23494975)
2013
9
Conversion disorder. (23622298)
2013
10
The chiropractic care of a child with extremity tremors concomitant with a medical diagnosis of conversion disorder. (22500845)
2012
11
The neural circuitry of conversion disorder and its recovery. (21859163)
2012
12
Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder. (21935985)
2011
13
Conversion disorder as initial diagnosis in pantothenate kinase associated neurodegeneration. (20717690)
2011
14
Treatment of conversion disorder in the 21st century: have we moved beyond the couch? (21468672)
2011
15
Conversion disorder: understanding the pathogenic links between emotion and motor systems in the brain. (20418528)
2010
16
Valproate in conversion disorder: a case report. (20671980)
2010
17
Abreaction for conversion disorder: systematic review with meta-analysis. (20679259)
2010
18
Increased activation in cingulate cortex in conversion disorder: what does it mean? (19733363)
2010
19
The involuntary nature of conversion disorder. (20083798)
2010
20
The neuropsychiatry of conversion disorder. (18382227)
2008
21
Physical therapy management for conversion disorder: case series. (17419887)
2007
22
Conversion disorder in Australian pediatric practice. (17195731)
2007
23
Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey. (17639308)
2007
24
Clinical profile and outcome of conversion disorder in children in a tertiary hospital of north India. (17459885)
2007
25
Conversion disorder: towards a neurobiological understanding. (19412442)
2006
26
Volumetric investigation of brain regions in patients with conversion disorder. (16600450)
2006
27
Healing the disembodied mind: contemporary models of conversion disorder. (15804930)
2005
28
Urinary retention, erectile dysfunction and penile anaesthesia after circumcision: a mixed dissociative (conversion) disorder. (16307335)
2005
29
Progress in understanding conversion disorder. (18568070)
2005
30
Case report: physiotherapy strategies for a patient with conversion disorder presenting abnormal gait. (16245757)
2005
31
Conversion disorder in a child presenting as sudden sensorineural hearing loss. (15964081)
2005
32
Sociodemographic and clinical characteristics of patients with conversion disorder in Eastern Turkey. (12563551)
2003
33
A randomized controlled clinical trial of a hypnosis-based treatment for patients with conversion disorder, motor type. (12825917)
2003
34
Deception or misinterpretation in case of a conversion disorder? (14630461)
2003
35
Conversion disorder in children and adolescents: a 4-year follow-up study. (11943237)
2002
36
Conversion disorder: difficulties in diagnosis using DSM-IV/ICD-10. (11759495)
2001
37
Reevaluation of serum cortisol in conversion disorder with seizure (pseudoseizure) (10749955)
2000
38
Polysymptomatic conversion disorder in childhood and adolescence in Japan. Early manifestation or incomplete form of somatization disorder? (10773777)
2000
39
Organic syndromes diagnosed as conversion disorder: identification and frequency in a study of 85 patients. (11053598)
2000
40
Conversion disorder and multiple chemical sensitivity: a comparative study of psychological defense strategies. (11153853)
2000
41
Distinguishing conversion disorder from neurologic impairment. (9140848)
1997
42
Conversion disorder presenting as a head injury. (9248922)
1997
43
Conversion disorder after maxillofacial trauma and surgery. (8727582)
1996
44
Hoarseness after cardiac operations: vocal cord paralysis or a conversion disorder? (8823130)
1996
45
Conversion disorder presenting as gait disturbance in an adolescent. (7647948)
1995
46
Diagnostic issues for conversion disorder. (1427673)
1992
47
Hyperemesis gravidarum as conversion disorder. (2230751)
1990
48
Visual conversion disorder: a case analysis of the influence of visual information. (2768670)
1989
49
The use of contingent reinforcement in the treatment of a conversion disorder: a multiple baseline study. (4086655)
1985
50
Factitious illness v conversion disorder. (6854863)
1983

Variations for Conversion Disorder

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Expression for genes affiliated with Conversion Disorder

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Search GEO for disease gene expression data for Conversion Disorder.

Pathways for genes affiliated with Conversion Disorder

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Compounds for genes affiliated with Conversion Disorder

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Compounds related to Conversion Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pyridoxal 5-phosphate449.7GAD1, COMT
2dopac449.6BDNF, COMT
3mhpg449.6BDNF, COMT
4antipsychotics509.6BDNF, COMT
5maoa449.6BDNF, COMT
6homovanillic acid44 2410.6BDNF, COMT
7pramipexole44 28 50 1112.5COMT, BDNF
8fluvoxamine44 50 1111.5COMT, BDNF
9venlafaxine44 50 24 1112.5COMT, BDNF
10selegiline44 1110.5BDNF, COMT
11heroin44 50 1111.5BDNF, COMT
12paroxetine44 50 28 1112.5COMT, BDNF
13methamphetamine44 50 1111.5COMT, BDNF
14risperidone44 50 28 60 24 1114.5BDNF, COMT
156-hydroxydopamine449.5BDNF, COMT
16olanzapine44 50 28 24 1113.5BDNF, COMT
17bicuculline44 2810.5GAD1, BDNF
18catecholamine449.4BDNF, COMT
19quinolinic acid44 2410.4GAD1, BDNF
20muscimol44 60 2811.4BDNF, GAD1
21valproate449.4BDNF, GAD1
22cocaine44 1110.4COMT, BDNF
23streptozotocin449.4BDNF, GAD1
24valine449.4COMT, BDNF
25tetrodotoxin44 60 2811.4BDNF, GAD1
26haloperidol44 50 28 1 1113.3BDNF, GAD1
27kainate44 2810.3GAD1, BDNF
28valproic acid44 50 24 1112.3GAD1, BDNF
29gold449.3GAD1, BDNF
30epinephrine44 24 1111.3COMT, BDNF
31bromodeoxyuridine449.3GAD1, BDNF
32ascorbic acid44 2410.2BDNF, COMT
33gnrh449.2GAD1, BDNF
34gaba449.2BDNF, GAD1
35tamoxifen44 50 28 1112.2BDNF, COMT
36ethanol44 50 24 1112.1COMT, BDNF
37norepinephrine44 24 1111.0BDNF, COMT
38potassium44 24 1111.0BDNF, GAD1
39mptp449.0COMT, GAD1, BDNF
40levodopa44 1110.0BDNF, GAD1, COMT
41clozapine44 28 50 1112.0BDNF, GAD1, COMT
42choline44 24 1111.0COMT, BDNF, GAD1
43methionine449.0COMT, GAD1, BDNF
44nmda44 289.9COMT, GAD1, BDNF
45estradiol44 24 1110.9BDNF, COMT, GAD1
46proline448.9GAD1, COMT, BDNF
47hydrogen44 249.9BDNF, COMT, GAD1
48dopamine44 28 24 1111.9BDNF, COMT, GAD1
49glutamate448.8GAD1, COMT, BDNF
50acetylcholine44 50 28 24 1112.7BDNF, GAD1

GO Terms for genes affiliated with Conversion Disorder

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Biological processes related to Conversion Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00072689.3GAD1, COMT
2neurotransmitter biosynthetic processGO:00421369.2GAD1, COMT
3response to drugGO:00424939.0GAD1, COMT

Sources for Conversion Disorder

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet