FND
MCID: CNV002
MIFTS: 50

Conversion Disorder (FND) malady

Neuronal diseases category

Summaries for Conversion Disorder

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained. symptoms may occur because of emotional distress or psychological problems. they usually begin suddenly after a stressful experience. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 9/20/2010

MalaCards: Conversion Disorder, also known as hysterical neurosis, conversion type, is related to herpes simplex and neuroblastoma. An important gene associated with Conversion Disorder is BDNF (brain-derived neurotrophic factor). The compounds bicuculline and muscimol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone marrow, and related mouse phenotype taste/olfaction.

Disease Ontology:8 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia:63 A conversion disorder causes patients to suffer from neurological symptoms, such as numbness, blindness,... more...

Aliases & Classifications for Conversion Disorder

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

conversion disorder 8 42 60
hysterical neurosis, conversion type 8
functional neurological disorder 42
conversion hysterical neurosis 8
functional movement disorder 42
frontonasal dysplasia 60
conversion hysteria 8
reaction 8
fnd 42


External Ids:

Disease Ontology8 DOID:1768
MeSH34 D003291
ICD9CM27 300.11
ICD1025 F43.9

Related Diseases for Conversion Disorder

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to conversion disorder

Clinical Features for Conversion Disorder

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Drugs & Therapeutics for Conversion Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Conversion Disorder

Search NIH Clinical Center for Conversion Disorder

Search CenterWatch for Conversion Disorder

Genetic Tests for Conversion Disorder

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Anatomical Context for Conversion Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Conversion Disorder:

32
Brain, Spinal cord, Bone marrow, Bone, Cortex, Myeloid, T cells, Cingulate cortex

Animal Models for Conversion Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Conversion Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.0GAD1, BDNF

Publications for Conversion Disorder

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50PubMed
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Articles related to Conversion Disorder:

(show top 50)    (show all 268)
idTitleAuthorsYear
1
Grey matter changes in motor conversion disorder. (23236016)
2014
2
Neuropsychological function and memory suppression in conversion disorder. (23582098)
2013
3
A prospective study of diagnostic conversion of major depressive disorder to bipolar disorder in pregnancy and postpartum. (24127853)
2013
4
Meige's Syndrome: Rare Neurological Disorder Presenting as Conversion Disorder. (24249940)
2013
5
Commentary on: A Case of Neurological Symptoms and Severe Urinary Retention on a Pediatric Ward: Is this Conversion Disorder? (23390436)
2013
6
Manic symptoms associated with pregabalin in a patient with conversion disorder. (23438171)
2013
7
Comparisons of childhood trauma, alexithymia, and defensive styles in patients with psychogenic non-epileptic seizures vs. epilepsy: Implications for the etiology of conversion disorder. (23915770)
2013
8
Spontaneous peer conversation in preschoolers with high-functioning autism spectrum disorder versus typical development. (24304222)
2013
9
Elevated left mid-frontal cortical activity prospectively predicts conversion to bipolar I disorder. (22775582)
2012
10
Treatment of conversion disorder in the 21st century: have we moved beyond the couch? (21468672)
2011
11
Conversion disorder: a missed diagnosis leading to cochlear reimplantation. (20962703)
2011
12
Increased activation in cingulate cortex in conversion disorder: what does it mean? (19733363)
2010
13
Bypassing Shame and Conversion Disorder. (21632008)
2010
14
Chronic subjective dizziness versus conversion disorder: discussion of clinical findings and rehabilitation. (20029054)
2010
15
Occupational therapy should be part of conversion disorder treatment. (20302262)
2010
16
Conversion disorder: separating "how" from "why". (20083794)
2010
17
In the psychiatrist's chair: how neurologists understand conversion disorder. (19321463)
2009
18
Neural correlates of motor conversion disorder. (19454778)
2009
19
Conversion disorder and coexisting nonepileptic seizures in patients with refractory seizures. (19703793)
2009
20
Electrophysiological correlates of motor conversion disorder. (18785215)
2008
21
Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey. (17639308)
2007
22
Conversion disorder: towards a neurobiological understanding. (19412442)
2006
23
Conversion disorder in stroke: a case report. (17110349)
2006
24
Unexplained neurologic symptoms: an fMRI study of sensory conversion disorder. (17159115)
2006
25
Post-operative paradoxical vocal cord movement due to non-organic conversion disorder. (16879482)
2006
26
Anxiety and depressive symptoms in patients with conversion disorder. (16202361)
2005
27
Cardiac angiography and conversion disorder. (16027644)
2005
28
Acute disseminated encephalomyelitis presenting as conversion disorder. (15939989)
2005
29
Case study: camptocormia, a rare conversion disorder. (15322421)
2004
30
Cognitive behavioural and neuropsychiatric treatment of post-traumatic conversion disorder: a case study. (15224624)
2004
31
Transcranial magnetic stimulation in the reversal of motor conversion disorder. (12920333)
2003
32
Conversion disorder in children and adolescents: a 4-year follow-up study. (11943237)
2002
33
Clinical characteristics [correction of characterstics] and outcome of children and adolescents with conversion disorder. (12196687)
2002
34
Hypnotic susceptibility in patients with conversion disorder. (12003460)
2002
35
Conversion disorder in children and adolescents: clinical features and comorbidity with depressive and anxiety disorders. (10936979)
2000
36
Multiple personality disorder following conversion and dissociative disorder nos : a case report. (21407917)
2000
37
Motor conversion disorder. A prospective 2- to 5-year follow-up study. (9819952)
1998
38
Distinguishing conversion disorder from neurologic impairment. (9140848)
1997
39
Clinical characteristics of patients with motor disability due to conversion disorder: a prospective control group study. (9221972)
1997
40
Conversion disorder revisited. (8848956)
1995
41
Tetanus, pseudotetanus, or conversion disorder: a diagnostic dilemma? (8488415)
1993
42
Conversion disorder presenting as primary fibromyalgia. (8493310)
1993
43
Conversion disorder in an adult incest survivor. (1880489)
1991
44
Treatment outcome for children and adolescents with conversion disorder. (2268836)
1990
45
The use of contingent reinforcement in the treatment of a conversion disorder: a multiple baseline study. (4086655)
1985
46
Pediatric management problem: conversion disorder. (3844720)
1985
47
Factitious illness v conversion disorder. (6854863)
1983
48
Conversion disorder following termination of pregnancy. (6848639)
1983
49
Interrelationships of conversion, psychogenic pain, and dissociative disorder symptoms. (6630698)
1983
50
Conversion disorder: a developmental response to stress in adolescence? (7267953)
1981

Genetic Variations for Conversion Disorder

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Expression for genes affiliated with Conversion Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Conversion Disorder

Search GEO for disease gene expression data for Conversion Disorder.

Pathways for genes affiliated with Conversion Disorder

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Compounds for genes affiliated with Conversion Disorder

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Conversion Disorder according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1bicuculline44 2811.1GAD1
2muscimol44 59 2812.0GAD1
3dopac449.7BDNF, COMT
4mhpg449.7COMT, BDNF
5maoa449.7COMT, BDNF
6homovanillic acid44 2410.7BDNF, COMT
7pramipexole44 49 28 1112.7COMT, BDNF
8selegiline44 1110.7COMT, BDNF
9paroxetine44 49 28 1112.7BDNF, COMT
10risperidone28 44 49 59 11 2414.7BDNF, COMT
11methamphetamine44 49 1111.7COMT, BDNF
126-hydroxydopamine449.6BDNF, COMT
13olanzapine49 44 28 11 2413.6BDNF, COMT
14catecholamine449.6COMT, BDNF
15cocaine44 1110.5BDNF, COMT
16pyridoxal 5-phosphate449.5COMT, GAD1
17quinolinic acid44 2410.4GAD1, BDNF
18valine449.4BDNF, COMT
19valproate449.4BDNF, GAD1
20streptozotocin449.3BDNF, GAD1
21ascorbic acid44 2410.3BDNF, COMT
22tetrodotoxin44 59 2811.3BDNF, GAD1
23haloperidol44 28 2 49 1113.3BDNF, GAD1
24valproic acid44 49 11 2412.3BDNF, GAD1
25kainate44 2810.2BDNF, GAD1
26gold449.2GAD1, BDNF
27bromodeoxyuridine449.1BDNF, GAD1
28gnrh449.0GAD1, BDNF
29epinephrine44 11 2411.0BDNF, COMT
30mptp448.9GAD1, BDNF, COMT
31levodopa44 119.9COMT, BDNF, GAD1
32clozapine44 28 49 1111.9GAD1, BDNF, COMT
33gaba448.9BDNF, GAD1
34choline44 11 2410.9COMT, BDNF, GAD1
35methionine448.9GAD1, BDNF, COMT
36nmda44 289.9GAD1, BDNF, COMT
37estradiol44 11 2410.9GAD1, BDNF, COMT
38proline448.9COMT, BDNF, GAD1
39hydrogen44 249.9GAD1, BDNF, COMT
40dopamine44 28 11 2411.9COMT, BDNF, GAD1
41glutamate448.8GAD1, BDNF, COMT

GO Terms for genes affiliated with Conversion Disorder

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16Gene Ontology
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Biological processes related to Conversion Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:0424939.1GAD1, COMT
2neurotransmitter biosynthetic processGO:0421368.8GAD1, COMT

Products for genes affiliated with Conversion Disorder

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  • Antibodies
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Sources for Conversion Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet