FND
MCID: CNV002
MIFTS: 41

Conversion Disorder (FND) malady

Categories: Rare diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Conversion Disorder

Aliases & Descriptions for Conversion Disorder:

Name: Conversion Disorder 12 50 42 14 69
Hysterical Neurosis, Conversion Type 12
Functional Neurological Disorder 50
Conversion Hysteria or Reaction 12
Conversion Hysterical Neurosis 12
Functional Movement Disorder 50
Dissociative Disorder 69
Fnd 50

Classifications:



External Ids:

Disease Ontology 12 DOID:1768
ICD10 33 F44
ICD9CM 35 300.11
MeSH 42 D003291
UMLS 69 C0009946

Summaries for Conversion Disorder

NIH Rare Diseases : 50 conversion disorder is a condition in which a person has blindness, paralysis, or other nervous system symptoms that cannot be explained by a physical illness or injury. symptoms may occur because of emotional distress or psychological conflict. they usually begin suddenly after a stressful experience or traumatic event. people are more at risk for a conversion disorder if they also have a medical illness, dissociative disorder, or personality disorder. psychotherapy and stress management training may help reduce symptoms. the affected body part or physical function will need physical or occupational therapy until the symptoms disappear. last updated: 6/25/2016

MalaCards based summary : Conversion Disorder, also known as hysterical neurosis, conversion type, is related to frontonasal dysplasia 1 and psychogenic movement, and has symptoms including waxy flexibility An important gene associated with Conversion Disorder is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways is Biogenic Amine Synthesis. The drugs Dopamine and Pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and myeloid.

Disease Ontology : 12 A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause.

Wikipedia : 71 Conversion disorder (CD) is a diagnostic category previously used in some psychiatric classification... more...

Related Diseases for Conversion Disorder

Diseases related to Conversion Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Related Disease Score Top Affiliating Genes
1 frontonasal dysplasia 1 11.7
2 psychogenic movement 11.0
3 dissociative disorder 10.6
4 chondrodysplasia lethal recessive 10.0 COMT GAD1
5 personality disorder 10.0 COMT GAD1
6 craniodiaphyseal dysplasia 10.0 ALX3 COMT
7 dissociative amnesia 9.9
8 lymphoma 9.9
9 chronic conjunctivitis 9.9 COMT GAD1
10 dissociative seizures 9.8
11 alexithymia 9.8
12 anorexia nervosa 9.7
13 reflex sympathetic dystrophy 9.7
14 epilepsy 9.6
15 hemiplegia 9.6
16 pulmonary hypertension 9.5
17 myopia 9.5
18 acute disseminated encephalomyelitis 9.5
19 incontinentia pigmenti 9.5
20 arachnoiditis 9.5
21 myeloid leukemia 9.5
22 locked-in syndrome 9.5
23 learning disability 9.5
24 guillain-barre syndrome 9.5
25 arachnoid cysts 9.5
26 brain injury 9.5
27 hypochondriasis 9.5
28 leukemia 9.5
29 dementia 9.5
30 pandas 9.5
31 addison's disease 9.5
32 sudden sensorineural hearing loss 9.5
33 somatization disorder 9.5
34 foot drop 9.5
35 ptosis 9.5
36 head injury 9.5
37 thrombosis 9.5
38 anxiety disorder 9.5
39 sensorineural hearing loss 9.5
40 astrocytoma 9.5
41 tremor 9.5
42 complex regional pain syndrome 9.5
43 serotonin syndrome 9.5
44 cerebritis 9.5
45 multiple chemical sensitivity 9.5
46 tetanus 9.5
47 spinal cord astrocytoma 9.5
48 west nile virus 9.5
49 epidural abscess 9.5
50 paraplegia 9.5

Comorbidity relations with Conversion Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Anxiety Disorder
Dysthymic Disorder Esophagitis
Hypertension, Essential Hypothyroidism
Schizophreniform Disorder Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Conversion Disorder:



Diseases related to Conversion Disorder

Symptoms & Phenotypes for Conversion Disorder

UMLS symptoms related to Conversion Disorder:


waxy flexibility

Drugs & Therapeutics for Conversion Disorder

Drugs for Conversion Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 725)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Pioglitazone Approved, Investigational Phase 4,Phase 3,Early Phase 1 111025-46-8 4829
3
Zinc Approved Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
4
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
5
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
6
Rifampin Approved Phase 4,Phase 3,Phase 2,Phase 1 13292-46-1 5458213 5381226
7
Iron Approved Phase 4 7439-89-6 23925
8
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
9
Tenofovir Approved, Investigational Phase 4,Phase 2 147127-20-6 464205
10
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
11
Pantoprazole Approved Phase 4 102625-70-7 4679
12
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
14
Lamivudine Approved, Investigational Phase 4,Phase 2 134678-17-4 60825
15
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
16
Adenosine Approved, Investigational Phase 4 58-61-7 60961
17
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
18
Isoniazid Approved Phase 4,Phase 3,Phase 2,Phase 1 54-85-3 3767
19
Pyrazinamide Approved Phase 4,Phase 3,Phase 2,Phase 1 98-96-4 1046
20
Citalopram Approved Phase 4,Phase 2,Phase 3 59729-33-8 2771
21
Pramipexole Approved, Investigational Phase 4,Phase 3 104632-26-0 59868 119570
22
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
23
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
24
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
25
Ropinirole Approved, Investigational Phase 4,Phase 3 91374-20-8, 91374-21-9 5095 497540
26
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
27
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
28
Ethambutol Approved Phase 4,Phase 3,Phase 2 74-55-5 3279 14052
29
Entecavir Approved, Investigational Phase 4,Phase 2 142217-69-4 153941
30
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
31
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
32
Menthol Approved Phase 4,Phase 1,Phase 2,Early Phase 1 2216-51-5 16666
33
Gatifloxacin Approved, Investigational Phase 4,Phase 3 112811-59-3 5379
34
Ranibizumab Approved Phase 4,Phase 2,Phase 3,Phase 1 347396-82-1 459903
35
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
36
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
37
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
38
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
39
Norepinephrine Approved Phase 4 51-41-2 439260
40
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
41
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
42
Probucol Approved Phase 4 23288-49-5 4912
43
Aspirin Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 50-78-2 2244
44
Verapamil Approved Phase 4 52-53-9 2520
45
Digoxin Approved Phase 4,Phase 3 20830-75-5 30322 2724385
46
Loperamide Approved Phase 4 53179-11-6 3955
47
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
48
Metformin Approved Phase 4,Phase 1 657-24-9 14219 4091
49
Ramipril Approved Phase 4,Phase 3 87333-19-5 5362129
50
Diltiazem Approved Phase 4 42399-41-7 39186

Interventional clinical trials:

(show top 50) (show all 962)
id Name Status NCT ID Phase
1 On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD) Unknown status NCT01670162 Phase 4
2 Reduction or Discontinuation of CNI's With Conversion to Everolimus-Based Immunosuppresion Unknown status NCT00443508 Phase 4
3 Characterisation of the Human Carboxylesterase 1 (CES1) Mutations in Thailand Unknown status NCT01443806 Phase 4
4 Study to Observe the Effect of Mirapex ER® Once-daily (QD) Versus Twice-daily (BID) Unknown status NCT01515774 Phase 4
5 Efficacy of Certican® in Combination With Myfortic® in Renal Unknown status NCT01399242 Phase 4
6 Impact of Conversion From Tacrolimus to Sirolimus in African American Renal Transplant Recipients Unknown status NCT00999258 Phase 4
7 "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER- Unknown status NCT02028234 Phase 4
8 Hepatitis C in Renal Transplant Recipients Unknown status NCT02108301 Phase 4
9 Tenofovir in Late Pregnancy to Prevent Vertical Transmission of Hepatitis B Virus Unknown status NCT01488526 Phase 4
10 Compare Tolerability of an Overnight Switch to Gradual Switch Between Two Different Forms of Depakote Unknown status NCT00312676 Phase 4
11 Cardioversion vs. Catheter Ablation for Persistent Atrial Fibrillation Unknown status NCT00196209 Phase 4
12 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
13 Vernakalant Versus Flecainide: Atrial Contractility Unknown status NCT01646281 Phase 4
14 Efficacy and Safety Study of Telbivudine to Prevent Perinatal Transmission Unknown status NCT00939068 Phase 4
15 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
16 Treatments for Psychogenic Nonepileptic Seizures (NES) Completed NCT00159965 Phase 4
17 Treatment Trial for Psychogenic Nonepileptic Seizures Completed NCT00835627 Phase 4
18 An Observational Study of Oral Fluoroquinolones and the Risk of Retinal Detachment Completed NCT01881438 Phase 4
19 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4
20 Intravitreal Ranibizumab in Retinal Pigment Epithelial Detachments Completed NCT00976222 Phase 4
21 Eylea to Treat Retinal Pigment Epithelial Detachment (RPED) Secondary to Wet Age-Related Macular Degeneration (wAMD) Completed NCT02142296 Phase 4
22 A Study to Determine Effective and Tolerable Titration Scheme for OROS-Methylphenidate in Children With Attention-deficit Hyperactivity Disorder Completed NCT00518232 Phase 4
23 The Role of Vitamin D in Immune Function in Patients With Chronic Kidney Disease (CKD) Stages 3 and 4. Completed NCT00749736 Phase 4
24 Study to Compare the Effect of Ropinirole Prolonged Release Once-daily Versus Twice-daily Completed NCT00986245 Phase 4
25 The Vienna Prograf and Endothelial Progenitor Cell Study Completed NCT00182559 Phase 4
26 A Study of EGb 761® (Tanakan®) in Dementia of Alzheimer Type Onset in Patients Suffering From Memory Complaints Completed NCT00276510 Phase 4
27 A Phase 4 Study to Determine Dosing of Hectorol® Capsules When Converting From Zemplar® Injection Completed NCT00463021 Phase 4
28 Olfactory Deficits in MCI as Predictor of Improved Cognition on Donepezil Completed NCT01845636 Phase 4
29 Antazoline in Rapid Cardioversion of Paroxysmal Atrial Fibrillation Completed NCT01527279 Phase 4
30 Once-a-day Immunosuppression(CISECON_a_day) Completed NCT01964014 Phase 4
31 Study on Costs and Safety of Early Conversion From Intravenous to Oral Antibiotic Treatment in Patients With Severe Community-Acquired Pneumonia Completed NCT00273676 Phase 4
32 Prostate Cancer Study In Men Who Have Failed First-Line Androgen Deprivation Therapy Completed NCT00470834 Phase 4
33 Preventing ICU Subsyndromal Delirium Conversion to Delirium With Haloperidol Completed NCT01174290 Phase 4
34 A Phase 4, Conversion Study of Hectorol® Injection to Hectorol® Capsules in Stage 5 CKD Patients on Dialysis Completed NCT00418600 Phase 4
35 Pharmacokinetic Study Of Valaciclovir Hydrochloride Tablets Completed NCT00343278 Phase 4
36 Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines Completed NCT01270503 Phase 4
37 Pioglitazone Study of Triglyceride Changes in Subjects With Type 2 Diabetes After Conversion From Rosiglitazone. Completed NCT00672919 Phase 4
38 Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients Completed NCT00369382 Phase 4
39 Combination Treatment Study for Memory Impairment and Depression Completed NCT01658228 Phase 4
40 A Trial Comparing Deep Versus Moderate Neuromuscular Block - in Low Pressure Pneumoperitoneum Completed NCT02602964 Phase 4
41 Endo-Laparoscopic Approach Versus Conventional Open Surgery in Obstructing Left-sided Colon Cancer: RCT Completed NCT00654212 Phase 4
42 Atrial Fibrillation Without Hemodynamic Instability in the Intensive Care Unit Completed NCT01461733 Phase 4
43 Cost Comparison Study of Darbepoetin Versus Epoetin Therapy to Treat Anemia in Hemodialysis Patients Completed NCT02817555 Phase 4
44 Insulin Secretion and Advagraf Completed NCT01092806 Phase 4
45 Cholesterol Lowering Treatment With Psyllium Husks and Isolated Soy Protein in Hypercholesterolemia Completed NCT01251991 Phase 4
46 Conversion From Tacrolimus to Cyclosporine Microemulsion in Liver Transplant Patients With New Onset Diabetes After the 3rd Month Post-transplant Completed NCT00171717 Phase 4
47 Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion Completed NCT00188773 Phase 4
48 Conversion of Hyperglycemic Patients Being Treated With Intravenous Insulin Infusions to Lantus Insulin Completed NCT00338104 Phase 4
49 Effects of Atorvastatin Versus Probucol on Small Dense LDL Completed NCT00276133 Phase 4
50 Safety and Efficacy Study of Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients Completed NCT01624948 Phase 4

Search NIH Clinical Center for Conversion Disorder

Cochrane evidence based reviews: conversion disorder

Genetic Tests for Conversion Disorder

Anatomical Context for Conversion Disorder

MalaCards organs/tissues related to Conversion Disorder:

39
Brain, Spinal Cord, Myeloid, Pituitary, Cortex, Cingulate Cortex

Publications for Conversion Disorder

Articles related to Conversion Disorder:

(show top 50) (show all 304)
id Title Authors Year
1
The classification of conversion disorder (functional neurologic symptom disorder) in ICD and DSM. ( 27719838 )
2017
2
Functional networks of motor inhibition in conversion disorder patients and feigning subjects. ( 27330971 )
2016
3
Can motor imagery and hypnotic susceptibility explain Conversion Disorder with motor symptoms? ( 27346334 )
2016
4
From conversion disorder (DSM-IV-TR) to functional neurological symptom disorder (DSM-5): When a label changes the perspective for the neurologist, the psychiatrist and the patient. ( 26723973 )
2016
5
Conversion Disorder in an Appalachian Community. ( 27490651 )
2016
6
Interdisciplinary rehabilitation approach for functional neurological symptom (conversion) disorder: A case study. ( 26689100 )
2016
7
Clinical Considerations Regarding Regression in Psychotherapy with Patients with Conversion Disorder. ( 27603802 )
2016
8
Life events and escape in conversion disorder. ( 27377290 )
2016
9
The role of psychiatrists in diagnosing conversion disorder: a mixed-methods analysis. ( 27274253 )
2016
10
Demonstration of Injury of the Corticospinal Tract in a Patient with Suspected Motor Conversion Disorder. ( 27386816 )
2016
11
Childhood Trauma and Alexithymia in Patients with Conversion Disorder. ( 27504555 )
2016
12
Erratum: Uncovering the etiology of conversion disorder: insights from functional neuroimaging [Corrigendum]. ( 27103807 )
2016
13
Aversive stimuli exacerbate defensive motor behaviour in motor conversion disorder. ( 27842291 )
2016
14
Poster 173 Concussions Presenting with Conversion Disorder: AA Case Series. ( 27672938 )
2016
15
Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder. ( 27283002 )
2016
16
Postoperative conversion disorder. ( 27041258 )
2016
17
Poster 294 Conversion Disorder Rehabilitation: A Case Report. ( 27673051 )
2016
18
Relationships among depression, anxiety, anxiety sensitivity, and perceived social support in adolescents with conversion disorder. ( 26824691 )
2016
19
Functional Neuroanatomy and Neurophysiology of Functional Neurological Disorders (Conversion Disorder). ( 26900733 )
2016
20
Evaluation of oxidant, antioxidant, and S100B levels in patients with conversion disorder. ( 27471386 )
2016
21
Uncovering the etiology of conversion disorder: insights from functional neuroimaging. ( 26834476 )
2016
22
Sense of body ownership in patients affected by functional motor symptoms (conversion disorder). ( 26704189 )
2016
23
Cognitive Behavioural Therapy and Adjunctive Physical Activity for Functional Movement Disorders (Conversion Disorder): A Pilot, Single-Blinded, Randomized Study. ( 27744440 )
2016
24
Emotion-motion interactions in conversion disorder: an FMRI study. ( 25859660 )
2015
25
Conversion Disorder- Mind versus Body: A Review. ( 26155375 )
2015
26
Childhood Trauma and Conversion Disorder in a 16-Year-Old Boy. ( 26445684 )
2015
27
Transmural dispersion of repolarization and atrial electromechanical coupling: complementary indices for quantifying cardiac electrical heterogeneity in patients with conversion disorder. ( 26229478 )
2015
28
Cognitive-analytical therapy for a patient with functional neurological symptom disorder-conversion disorder (psychogenic myopia): A case study. ( 26487881 )
2015
29
Hospital revisit rate after a diagnosis of conversion disorder. ( 25855400 )
2015
30
An atypical presentation of visual conversion disorder. ( 25744066 )
2015
31
Group Dialectical-Behavior Therapy Skills Training for Conversion Disorder With Seizures. ( 25959039 )
2015
32
Recurrence of conversion disorder symptoms in a successfully treated 16-year-old female. ( 26510710 )
2015
33
Paralympics and conversion disorder. ( 25948495 )
2015
34
Conversion disorder in a preschool age girl. ( 25972349 )
2015
35
Pituitary volumes are changed in patients with conversion disorder. ( 25877743 )
2015
36
Somatoform and Conversion Disorder Preceding Lewy Body Dementia: A Newly Described Phenomenological Manifestation of the Disease. ( 26390000 )
2015
37
Temperament and character traits in patients with conversion disorder and their relations with dissociation. ( 26609652 )
2015
38
Conversion Disorder; an Unusual Etiology of Unilateral Foot Drop. ( 26179836 )
2015
39
Knowledge of conversion disorder in children by pediatricians in a developing country. ( 25966728 )
2015
40
Efficacy of brief interdisciplinary psychotherapeutic intervention for motor conversion disorder and nonepileptic attacks. ( 26099544 )
2015
41
P-wave and QT dispersion in patients with conversion disorder. ( 25848293 )
2015
42
Monolimb paralysis after laparoscopic appendectomy due to conversion disorder. ( 25426280 )
2014
43
The modified gait abnormality rating scale in patients with a conversion disorder: A reliability and responsiveness study. ( 25304088 )
2014
44
Interobserver agreement and validity of bedside 'positive signs' for functional weakness, sensory and gait disorders in conversion disorder: a pilot study. ( 24994927 )
2014
45
First episode of psychosis in a middle-aged patient with a 14-year history of conversion disorder. ( 25580341 )
2014
46
The value of 'positive' clinical signs for weakness, sensory and gait disorders in conversion disorder: a systematic and narrative review. ( 23467417 )
2014
47
Is physiotherapy effective in the management of child and adolescent conversion disorder? A systematic review. ( 24923418 )
2014
48
Functional neuroimaging of conversion disorder: The role of ancillary activation. ( 25379447 )
2014
49
Psychiatric comorbidity in patients with conversion disorder and prevalence of dissociative symptoms. ( 25365395 )
2014
50
Neural correlates of recall of life events in conversion disorder. ( 24258270 )
2014

Variations for Conversion Disorder

Expression for Conversion Disorder

Search GEO for disease gene expression data for Conversion Disorder.

Pathways for Conversion Disorder

Pathways related to Conversion Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
9.97 COMT GAD1

GO Terms for Conversion Disorder

Sources for Conversion Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....