Copd malady

CDC: Chronic Obstructive Pulmonary Disease, or COPD, refers to a group of diseases that cause airflow blockage and breathing-related problems. It includes emphysema, chronic bronchitis, and in some cases asthma.1²

MalaCards: Copd, also known as chronic obstructive airway disease, is related to chronic obstructive pulmonary disease and asthma. An important gene associated with Copd is COPD (Pulmonary disease, chronic obstructive, severe early-onset), and among its related pathways are Bacterial infections in CF airways and Amoebiasis. The compounds nitric oxide and ethanol have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and whole blood, and related mouse phenotypes are respiratory system and hematopoietic system.

copd 7 chronic obstructive airway disease 43

Diseases related to copd by text searches and GeneDecks gene sharing:

(show top 50)    (show all 930)

id	Related Disease	Score	Top Affiliating Genes
1	chronic obstructive pulmonary disease	39.5	PDE4A, SFTPB, SFTPD, GC, SELPLG, SERPINA1
2	asthma	35.6	IL13, IL4, IL5, IGHE, RNASE3, KNG1
3	emphysema	35.2	SFTPB, SFTPD, SESN2, SERPINE2, SERPINA1, SERPINE1
4	pulmonary disease	34.7	PDE4A, PDE4C, VWF, SFTPB, SFTPD, GC
5	bronchitis	34.2	SERPINA1, SERPINB1, VIP, LACTB, CFTR, MPO
6	pulmonary hypertension	32.5	PDE4A, SFTPB, VIP, VIPR1, CAV1, TNC
7	alpha 1-antitrypsin deficiency	31.7	SFTPB, GC, SERPINE2, SERPINA1, SERPINE1, SERPINA3
8	pulmonary function	31.3	SFTPB, SERPINA1, LEP, CFTR, MPO, GYPA
9	respiratory failure	30.8	PDE4A, SFTPB, SFTPD, SCGB1A1, MUC5AC, LACTB
10	cor pulmonale	30.1	VWF, FGF2, CAT, CALCA, LTA, EDN1
11	obstructive lung disease	29.8	PDE4A, SERPINA1, SERPINA3, LACTB, IGHE, ALB
12	pulmonary emphysema	29.8	SFTPD, SESN2, SERPINA1, SERPINB1, VEGFA, BAX
13	bronchiectasis	28.3	SERPINA1, SERPINA3, SERPINB1, BPI, CFTR, MPO
14	diffuse panbronchiolitis	28.1	GC, MUC5AC, MUC5B, MPO, IL13, IL1B
15	panbronchiolitis	28.1	GC, MUC5AC, MUC5B, MPO, IL13, IL1B
16	idiopathic pulmonary fibrosis	27.6	MPO, MMP1, MMP2, FGF2, IL1B, IL8
17	rabies	27.2	SFRP2, SFTPB, GC, SERPINE2, VIP, BSG
18	haemophilus influenzae	26.3	MUC5AC, BAMBI, LBP, LACTB, MPO, IL10
19	muscular atrophy	26.1	PARP1, BCL2, MSTN, AREG, IL5, CCL4
20	lung carcinoma	26.0	SFTPB, SFTPD, SELL, SERPINA1, SERPINA3, VIPR1
21	carcinoma	24.8	PIK3C2A, PDE4A, RELA, VWF, SFRP2, SFTPB
22	bronchial asthma	24.5	SFTPD, SELL, SELP, VIP, VEGFA, BGLAP
23	eosinophilia	24.4	PIK3C2A, PDE4A, SFTPD, SELL, SERPINA1, MPO
24	non-small cell lung carcinoma	24.4	SFTPB, SFTPD, VEGFA, PARP1, KDR, BCL2
25	hypertension	22.8	PIK3C2A, PDE4A, VWF, SFTPB, GCLC, SELL
26	influenza	22.8	PIK3C2A, RELA, SFTPD, SELL, SERPINE1, RARA
27	cystic fibrosis	22.2	PDE4A, VWF, SFTPB, SFTPD, GCLC, GC
28	fibrosis	21.7	PDE4A, RELA, VWF, SFTPB, SFTPD, GCLC
29	pulmonary fibrosis	21.6	VWF, SFTPB, SFTPD, SERPINA1, SERPINE1, SERPINB1
30	pneumonia	21.6	PIK3C2A, PDE4A, RELA, SFTPB, SFTPD, SELL
31	osteoporosis	21.3	PDE4A, GC, VEGFA, VDR, BMP6, BGLAP
32	insulin resistance	21.1	RELA, VWF, SELL, SELP, SERPINE1, SERPINA3
33	prostatitis	19.9	PIK3C2A, PDE4A, RELA, VWF, SFRP2, SFTPD
34	ischemia	19.8	PIK3C2A, PDE4A, RELA, VWF, GC, SELL
35	blindness	19.2	PIK3C2A, PDE4A, VWF, SELP, SERPINE1, VIP
36	hypoxia	18.1	PIK3C2A, PDE4A, RELA, VWF, SFTPB, SESN2
37	adult respiratory distress syndrome	14.7	SFTPB, SERPINA1, LBP, IL8, ALOX5, TNF
38	lacrimal duct obstruction	14.6	PDE4A, SFTPB, SELL, SERPINA1, MUC5AC, XDH
39	status asthmaticus	14.3	PIK3C2A, MUC5AC, MMP9, IL5, IL8, CCL11
40	viral meningitis	14.2	SERPINA1, IL6, IL8, CCL5, CRP, CXCL10
41	behcet's disease	14.2	SELL, IL18, IL2RA, IL8, MBL2, CCL3
42	exfoliation syndrome	14.2	MPO, GSTM1, GSTP1, GSTT1, CAT, ELN
43	asbestosis	14.2	SERPINA1, MPO, CDKN1A, GSTM1, GSTP1, GSTT1
44	skin disease	14.2	PDE4A, SFTPD, SELL, VIP, VDR, CHUK
45	refractive error	14.2	VIP, MMP1, MMP12, MMP13, MMP2, MMP8
46	periodontal disease	14.2	BSG, BGLAP, MMP1, MMP13, MMP2, MMP8
47	pulmonary eosinophilia	14.2	PDE4A, SFTPD, SERPINA1, IL13, IL4, IL5
48	bacteremia, protection against	14.2	BPI, LBP, LACTB, MBL2, CAT, HMGCR
49	congenital heart defect	14.2	PIK3C2A, VIP, GSR, MAPK14, MAPK10, HMOX1
50	cadasil	14.1	VWF, GC, SELL, SELP, SELPLG, SERPINE1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to copd:

²²

MGI Mouse Phenotypes related to copd:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	11.5	SFTPD, SESN2, SELL, SELP, SERPINB1, MYOD1
2	hematopoietic system phenotype	MP:0005397	10.4	SERPINB1, BCL2, UNG, CHUK, LCN2, MT2A
3	endocrine/exocrine gland phenotype	MP:0005379	10.4	SFRP2, SELL, SERPINE2, VIPR1, CHRM3, XDH
4	immune system phenotype	MP:0005387	10.3	PDE4A, VWF, SELL, SELP, SELPLG, SERPINE2
5	embryogenesis phenotype	MP:0005380	10.0	SFRP2, GCLC, PARP1, CHUK, YY1, FLCN
6	normal phenotype	MP:0002873	9.9	RELA, SFRP2, GCLC, VIP, VEGFA, MYOD1
7	mortality/aging	MP:0010768	9.5	PIK3C2A, RELA, VWF, SFRP2, SFTPB, SFTPD
8	no phenotypic analysis	MP:0003012	9.5	SFRP2, SESN2, SERPINE2, VEGFA, MYOD1, PARP1
9	nervous system phenotype	MP:0003631	9.5	PDE4A, RELA, VWF, SFRP2, SELP, SERPINE2
10	reproductive system phenotype	MP:0005389	9.4	SFRP2, SERPINE2, VIP, VIPR2, VEGFA, VDR
11	renal/urinary system phenotype	MP:0005367	8.8	SELP, SELPLG, RARA, BCL2, SCGB1A1, LEPR
12	other phenotype	MP:0005395	8.6	RARA, KDR, LEPR, MSR1, CDKN2A, IL13
13	liver/biliary system phenotype	MP:0005370	8.5	GCLC, VEGFA, CHRM3, LBP, MT2A, CFTR
14	integument phenotype	MP:0010771	8.4	RELA, SELP, SELPLG, PARP1, BCL2, LEPR
15	behavior/neurological phenotype	MP:0005386	8.3	SFTPB, SELP, SERPINE2, VIP, VIPR1, VIPR2
16	growth/size phenotype	MP:0005378	7.7	PIK3C2A, RELA, SFRP2, SFTPD, GCLC, SELP
17	digestive/alimentary phenotype	MP:0005381	7.5	VWF, VIPR1, VEGFA, VDR, RARA, BCL2
18	skeleton phenotype	MP:0005390	7.1	RELA, GC, VEGFA, VDR, MYOD1, BMP6
19	hearing/vestibular/ear phenotype	MP:0005377	6.9	VDR, RARA, PARP1, BCL2, CHUK, CHRM1
20	adipose tissue phenotype	MP:0005375	6.7	PIK3C2A, SERPINE1, VIPR2, MYOD1, BCL2, LEP
21	homeostasis/metabolism phenotype	MP:0005376	6.6	PIK3C2A, RELA, VWF, SFRP2, SFTPB, SFTPD
22	muscle phenotype	MP:0005369	6.4	RELA, SFRP2, VEGFA, MYLK3, MYOD1, RARA
23	vision/eye phenotype	MP:0005391	5.8	RELA, SELP, VEGFA, RARA, KDR, BCL2
24	tumorigenesis	MP:0002006	5.6	SELL, SERPINE1, RARA, BCL2, UNG, SCGB1A1
25	cardiovascular system phenotype	MP:0005385	5.1	PDE4A, RELA, VWF, SFRP2, SELL, SELP
26	cellular phenotype	MP:0005384	4.5	RELA, VWF, SFRP2, GCLC, GCLM, SESN2

Articles related to copd:

(show top 50)    (show all 438)

id	Title	Authors	Year	Affiliating Genes
1	Reduced soluble receptor for advanced glycation end-p roducts in COPD. (20595148)	Smith D.J.... Upham J.W.	2011	AGER
2	Yin Yang 1 expression and localisation in quadriceps muscle in COPD. (21565439)	Natanek S.A.... Kemp P.R.	2011	YY1
3	The COPD genetic association compendium: a comprehens ive online database of COPD genetic associations. (19933216)	Castaldi P.J.... Trikalinos T.A.	2010	GSTP1, TGFB1, MMP9
4	Systemic inflammatory markers in COPD: results from t he Bergen COPD Cohort Study. (19643942)	Eagan T.M.... Bakke P.S.	2010	TNFRSF1A, TNFRSF11B, CRP
5	Mono- and combination therapy of long-acting bronchod ilators and inhaled corticosteroids in advanced COPD. (20496301)	Ohar J.A.... Donohue J.F.	2010	ADCY1
6	Serum levels of VEGF and bFGF in hypoxic patients wit h exacerbated COPD. (20504760)	Pavlisa G.... Jaksic B.	2010	FGF2, VEGFA
7	Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD. (20106877)	Wempe F.... von Melchner H.	2010	SESN2
8	Low erythropoietin plasma levels during exacerbations of COPD. (19955699)	Sala E.... AgustA- A.	2010	EPO
9	Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. (20673035)	SA... Hersh C.P.	2010	SOD3
10	Association of COPD candidate genes with CT emphysema and airway phenotypes in severe COPD. (20525719)	Kim W.J.... Silverman E.K.	2010	GSTP1, TGFB1, ADRB2
11	Association of MMP-2 polymorphisms with severe and ve ry severe COPD: a case control study of MMPs-1, 9 and 12 in a European populati on. (20078883)	Haq I.... Kalsheker N.	2010	MMP9, MMP1, MMP12
12	Role for Interleukin-6 in COPD-Related Pulmonary Hypertension. (19349390)	Chaouat A.... Adnot S.	2009	IL6, IL1B, CCL5
13	A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. (19300482)	Pillai S.G.... Goldstein D.B.	2009	CHRNA5
14	Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity. (19423314)	Lee J.... Dahl M.	2009	ACE
15	Nutritional status in relation to respiratory impairm ent and systemic inflammation in patients with acute exacerbations of COPD. (19789512)	Skyba P.... Tkacova R.	2009	SOD1, CAT, CRP
16	Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. (19197141)	Borchers M.T.... Orozco-Levi M.	2009	KLRK1
17	Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. (20003279)	Wang X.... Lv F.	2009	ADAM33
18	Inflammatory cytokines and repair factors in the int ercostal muscles of patients with severe COPD (19403222)	Casadevall C.... Gea J.	2009	CDH15, MYOD1, F2RL1
19	Proteomic analysis in lung tissue of smokers and COPD patients. (18753468)	Lee E.J.... Uhm C.S.	2009	MMP13, NME9
20	Transient elevation of neutrophil proteinases in induced sputum during COPD exacerbation. (19378434)	Ilumets H.... Kinnula V.L.	2008	MMP8
21	The CFTR M470V gene variant as a potential modifier of COPD severity: study of Serbian population. (18652532)	Stankovic M.... Radojkovic D.	2008	CFTR
22	Interleukin-1beta targeted therapy in severe persistent asthma (SPA) and chronic obstructive pulmonary disease (COPD): proposed similarities between biphasic pathobiology of SPA/COPD and ischemia-reperfusion injury. (19160937)	Wanderer A.A.	2008	NLRP3
23	Genetic Associations With Hypoxemia and Pulmonary Arterial Pressure in COPD. (19017876)	Castaldi P.J.... Silverman E.K.	2008	GSTP1, TGFB1, EPHX1
24	Interleukin-18 production and pulmonary function in COPD. (17989120)	Imaoka H.... Aizawa H.	2008	IL18
25	Serum and bronchial lavage fluid concentrations of IL-8, SLPI, sCD14 and sICAM-1 in patients with COPD and asthma. (17574828)	Hollander C.... Janciauskiene S.M.	2007	IL8, SLPI
26	Impaired TNFalpha-induced VEGF expression in human airway smooth muscle cells from smokers with COPD: role of MAPkinases and histone acetylation--effect of dexamethasone. (17906365)	Raidl M.... Koch A.	2007	TNF, VEGFA
27	Oxidative stress in patients with COPD and pulmonary hypertension. (17671825)	Joppa P.... TkA!covA! R.	2007	SOD1, CAT
28	Systemic cytokines, clinical and physiological changes in patients hospitalized for exacerbation of COPD. (17218554)	Pinto-Plata V.M.... Celli B.R.	2007	TNF, IL6, IL8
29	The relationship between inflammatory markers and disability in chronic obstructive pulmonary disease (COPD). (17665081)	Garrod R.... Hagan G.	2007	CRP
30	Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. (18034897)	MacRedmond R.E.... O'Neill S.J.	2007	IL8, TLR4, DEFB4A
31	Lung tissue and tumour-infiltrating T lymphocytes in patients with non-small cell lung carcinoma and chronic obstructive pulmonary disease (COPD): moderate/severe versus mild stage of COPD. (17949407)	Marc M.M.... Kosnik M.	2007	CD27
32	Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients. (17617905)	Harju T.H.... Kinnula V.L.	2007	GSTO1
33	C-reactive protein in patients with COPD, control smokers and non-smokers. (16143583)	Pinto-Plata V.M.... Celli B.R.	2006	CRP
34	Association analysis of tissue inhibitor of metalloproteinase2 gene polymorphisms with COPD in Egyptians. (15672858)	Hegab A.E.... Sekizawa K.	2005	TIMP2
35	The investigation of genotype and expression of alpha1-AT in patients with COPD (16029614)	Zhang Y.... Yao W.Z.	2005	SERPINA1
36	Increased IgE-antibodies to Staphylococcus aureus enterotoxins in patients with COPD. (15338798)	Rohde G.... Bachert C.	2004	IGHE
37	Matrix metalloproteinases in the pathogenesis of asthma and COPD: implications for therapy. (15174890)	Suzuki R.... Taniguchi H.	2004	MMP12
38	Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. (15047569)	Barber R.... Heeke G.V.	2004	PDE4A, PDE4C
39	Expression of transforming growth factor beta1 in bronchial biopsies in asthma and COPD. (14736088)	Kokturk N.... Akyol G.	2003	TGFB1
40	Increased production of TGF-beta and apoptosis of T lymphocytes isolated from peripheral blood in COPD. (12851215)	Hodge S.J.... Holmes M.	2003	ANXA5
41	Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections. (12761563)	Yang I.A.... Fong K.M.	2003	MBL2
42	Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. (12684317)	Beeh K.M.... Barnes P.J.	2003	IL8
43	Airways inflammation and COPD: epithelial-neutrophil interactions. (12010843)	Pettersen C.A.... Adler K.B.	2002	ELANE
44	Matrix metalloproteinases and TIMP-1 production by peripheral blood granulocytes from COPD patients and asthmatics. (11167375)	Cataldo D.... Louis R.	2001	TIMP1
45	Tumor necrosis factor gene complex in COPD and disseminated bronchiectasis. (10807822)	Patuzzo C.... Luisetti M.	2000	TNF, LTA
46	Genetic risk factors for chronic obstructive pulmonary disease (COPD) (10497389)	Miki M.... Satoh K.	1999	CYP1A1, GC, SERPINA3
47	Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic. (10373396)	Torphy T.J.... Compton C.H.	1999	PDE4A
48	Glucocorticoid receptor mRNA levels in bronchial epithelial cells of patients with COPD: influence of glucocorticoids. (9926163)	Korn S.H.... Wouters E.F.	1998	MT2A
49	Airway inflammation in COPD assessed by sputum levels of interleukin-8. (9266891)	Yamamoto C.... Narita N.	1997	MPO, IL8
50	Effects of ACE inhibition on sodium excretion in COPD. (7785024)	Jolobe O.M.	1995	ACE

Genes related to copd according to GeneCards:

(show top 50)    (show all 313)

id	Symbol	Description	Score	GeneCards Section Context
1	COPD	Pulmonary disease, chronic obstructive, severe early-onset	11.1	Gene
2	YSK4	YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)	11.1	Orthologs, Aliases & Descriptions
3	HHIP	hedgehog interacting protein	11.0	Publications, Summaries
4	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.0	Summaries
5	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
6	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
7	COPD24	Chronic obstructive pulmonary disease QTL 24	10.9	Gene
8	COPD25	Chronic obstructive pulmonary disease QTL 25	10.9	Gene
9	COPD26	Chronic obstructive pulmonary disease QTL 26	10.9	Gene
10	COPD8	Chronic obstructive pulmonary disease QTL 8	10.9	Gene
11	COPD16	Chronic obstructive pulmonary disease QTL 16	10.9	Gene
12	COPD11	Chronic obstructive pulmonary disease QTL 11	10.9	Gene
13	COPD6	Chronic obstructive pulmonary disease QTL 6	10.9	Gene
14	COPD13	Chronic obstructive pulmonary disease QTL 13	10.9	Gene
15	COPD5	Chronic obstructive pulmonary disease QTL 5	10.9	Gene, Publications
16	COPD20	Chronic obstructive pulmonary disease QTL 20	10.9	Gene
17	COPD10	Chronic obstructive pulmonary disease QTL 10	10.9	Gene
18	COPD29	Chronic obstructive pulmonary disease QTL 29	10.9	Gene
19	COPD14	Chronic obstructive pulmonary disease QTL 14	10.9	Gene
20	COPD28	Chronic obstructive pulmonary disease QTL 28	10.9	Gene
21	COPD27	Chronic obstructive pulmonary disease QTL 27	10.9	Gene
22	COPD7	Chronic obstructive pulmonary disease QTL 7	10.9	Gene
23	COPD17	Chronic obstructive pulmonary disease QTL 17	10.9	Gene
24	COPD12	Chronic obstructive pulmonary disease QTL 12	10.9	Gene
25	COPD9	Chronic obstructive pulmonary disease QTL 9	10.9	Gene
26	COPD18	Chronic obstructive pulmonary disease QTL 18	10.9	Gene
27	COPD15	Chronic obstructive pulmonary disease QTL 15	10.9	Gene
28	COPD19	Chronic obstructive pulmonary disease QTL 19	10.9	Gene
29	COPD1	Chronic obstructive pulmonary disease QTL 1	10.9	Gene
30	COPD3	Chronic obstructive pulmonary disease QTL 3	10.9	Gene
31	COPD4	Chronic obstructive pulmonary disease QTL 4	10.9	Gene
32	COPD23	Chronic obstructive pulmonary disease QTL 23	10.9	Gene
33	COPD2	Chronic obstructive pulmonary disease QTL 2	10.9	Gene
34	COPD21	Chronic obstructive pulmonary disease QTL 21	10.9	Gene
35	COPD22	Chronic obstructive pulmonary disease QTL 22	10.9	Gene
36	MUC8	mucin 8	10.9	Publications
37	MIR1-1	microRNA 1-1	10.9	Publications
38	GMCL1P1	germ cell-less, spermatogenesis associated 1 pseudogene 1	10.9	Publications
39	FGL2	fibrinogen-like 2	10.9	Publications
40	ZBTB9	zinc finger and BTB domain containing 9	10.9	Publications
41	EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	10.9	Publications
42	SOD3	superoxide dismutase 3, extracellular	10.9	Publications
43	RPL32	ribosomal protein L32	10.9	Publications
44	PDE4A	phosphodiesterase 4A, cAMP-specific	10.9	Publications
45	AGPHD1	aminoglycoside phosphotransferase domain containing 1	10.9	Publications
46	NME9	NME/NM23 family member 9	10.9	Publications
47	HYAL2	hyaluronoglucosaminidase 2	10.9	Publications
48	SESN2	sestrin 2	10.9	Publications
49	CCL13	chemokine (C-C motif) ligand 13	10.9	Publications
50	ADAM33	ADAM metallopeptidase domain 33	10.9	Publications

Pathways related to copd according to GeneDecks:

(show top 50)    (show all 141)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.9	RELA, SFTPD, CHUK, LBP, CFTR, TLR2
2	Amoebiasis20	10.8	RELA, SERPINB1, ITGAM, IL1B, IL1R2, IL6
3	Toll-like receptor signaling pathway20	10.3	RELA, CHUK, LBP, JUN, IL1B, IL6
4	Akt Signaling36	10.1	CHUK, CD4, ITGAE, ITGAM, FLT3, IL10
5	RAR-Gamma-RXR-Alpha Degradation36	10.1	IL2, MAPK14, MAPK10, CCL4, CCL11, CCL3
6	IL-6 Pathway36	10.0	BMP6, BAX, IL10, IL18, IL4, IL5
7	Regulation of eIF4 and p70S6K36	9.7	BAX, CD4, ITGAE, ITGAM, IL13, IL18
8	Immune response IL-1 signaling pathway10	9.6	RELA, SERPINE1, CHUK, JUN, FOSL2, IL1B
9	Immune response_IL-1 signaling pathway41	9.6	RELA, SERPINE1, CHUK, JUN, FOSL2, IL1B
10	Malaria20	9.5	SELP, GYPA, IL10, IL18, IL1B, IL6
11	Rheumatoid arthritis20	9.4	VEGFA, JUN, MMP1, IL18, IL1B, IL6
12	Immune response MIF-mediated glucocorticoid regulation10	9.4	RELA, CHUK, JUN, MMP1, IL2, IL6
13	Immune response_MIF-mediated glucocorticoid regulation41	9.3	RELA, CHUK, JUN, MMP1, IL2, IL6
14	ERK Signaling36	9.2	BMP6, CHUK, ITGAE, ITGAM, FLT3, AREG
15	Immune response MIF in innate immunity response10	9.2	RELA, CHUK, LBP, JUN, IL1B, IL6
16	Immune response_MIF in innate immunity response41	9.1	RELA, CHUK, LBP, JUN, IL1B, IL6
17	PPAR Pathway36	9.1	ITGAE, ITGAM, AREG, FGF2, IL2, IL2RA
18	ILK Signaling36	9.0	KDR, JUN, CDH15, ITGAM, FLT3, AREG
19	NF-KappaB (p50-p65) Pathway36	8.9	RELA, BMP6, KDR, CHUK, AREG, FGF2
20	NF-KappaB Family Pathway36	8.8	RELA, BMP6, KDR, CHUK, AREG, FGF2
21	Chagas disease (American trypanosomiasis)20	8.7	RELA, SERPINE1, CHUK, JUN, IL10, IL1B
22	Apoptotic Pathways in Synovial Fibroblasts36	8.7	BMP6, KDR, AREG, FGF2, IL2, IL2RA
23	Colorectal Cancer Metastasis36	8.7	BAX, MSH6, CDKN1A, MMP1, MMP12, MMP2
24	Tuberculosis20	8.5	RELA, VDR, BCL2, BAX, LBP, ITGAM
25	NFAT Signaling and Lymphocyte Interactions36	8.4	BMP6, BCL2, BAX, CD4, IL13, IL2
26	Endothelin-1 Signaling Pathway36	8.4	BMP6, FLT3, IL10, IL13, IL18, IL1B
27	Cytokine-cytokine receptor interaction20	8.3	VEGFA, KDR, LEP, LEPR, CD27, FLT3
28	PEDF Induced Signaling36	8.2	RELA, BMP6, BCL2, CHUK, BAX, IL10
29	JNK Pathway36	8.2	BMP6, KDR, BCL2, BAX, JUN, CD4
30	Renin-Angiotensin Pathway36	8.2	BMP6, KDR, CHUK, JUN, AREG, FGF2
31	PGC1Alpha Pathway36	8.2	BMP6, BCL2, BAX, CD4, IL10RA, IL13
32	all-trans-Retinoic Acid Signaling in Brain36	8.1	BMP6, RARA, BCL2, BAX, IL10, IL13
33	Pathways in cancer20	8.0	RELA, VEGFA, RARA, BCL2, CHUK, BAX
34	MIF Mediated Glucocorticoid Regulation36	7.9	BMP6, BCL2, BAX, IL10, IL13, IL18
35	STAT3 Pathway36	7.8	BMP6, BCL2, BAX, CDKN1A, CD4, IL10
36	Rho Family GTPases36	7.7	BMP6, KDR, BCL2, BAX, JUN, CDH15
37	Molecular Mechanisms of Cancer36	7.5	BMP6, RARA, KDR, BCL2, BAX, JUN
38	MAPK Signaling36	7.4	BMP6, KDR, BCL2, CHUK, JUN, ITGAE
39	Glucocorticoid Receptor Signaling36	7.3	BMP6, BCL2, BAX, JUN, CDKN1A, CD4
40	MIF Regulation of Innate Immune Cells36	7.3	BMP6, BCL2, BAX, JUN, IL10, IL13
41	SOCS Pathway36	7.3	BMP6, BCL2, BAX, CD4, INS, FGF2
42	Pancreatic Adenocarcinoma36	7.3	BMP6, KDR, BCL2, CDKN1A, CDKN2A, MMP1
43	Tec Kinases Signaling36	7.2	BMP6, BCL2, BAX, CD4, ITGAE, ITGAM
44	Cellular Apoptosis Pathway36	7.0	BMP6, KDR, BCL2, CHUK, BAX, CDKN2A
45	Antioxidant Action of Vitamin-C36	7.0	BMP6, KDR, BCL2, CHUK, BAX, JUN
46	PAK Pathway36	7.0	BMP6, KDR, BCL2, BAX, AREG, FGF2
47	MAPK Family Pathway36	6.8	BMP6, KDR, BCL2, CHUK, BAX, JUN
48	TGF-Beta Pathway36	6.8	BMP6, KDR, BCL2, BAX, JUN, CD4
49	JAK-STAT Pathway36	6.5	BMP6, KDR, BCL2, BAX, JUN, CD4
50	p38 Signaling36	6.5	BMP6, KDR, BCL2, BAX, CD4, FLT3

Compounds related to copd according to GeneDecks:

(show top 50)    (show all 546)

id	Compound	Score	Top Affiliating Genes
1	nitric oxide32 9 18 9	14.6	PDE4A, SFTPB, SFTPD, GCLM, SELP, SERPINA1
2	ethanol32 34 9 18 9	15.5	GCLC, SERPINA1, BPI, MYLK3, SDHB, LEPR
3	ionomycin32	11.1	SERPINA3, CHUK, CD69, GZMA, IL5, CCL4
4	p00232	11.1	SCGB1A1, LEP, CD63, ITGAM, MMP13, MMP8
5	endotoxin32	11.0	SFTPD, GC, SELL, BPI, SCGB1A1, LEPR
6	dopamine32 9 18 9	13.9	PDE4A, SERPINA3, VIP, BMP6, SDHB, LEPR
7	n-formylmethionyl-leucylphenylalanine32	10.7	SELL, SELP, SELPLG, LCN2, MPO, ITGAM
8	fmlp32	10.7	PDE4A, GC, SELL, SELP, SELPLG, SERPINA3
9	leukotriene b432 42 18	12.6	PDE4A, GC, SELL, SELP, LCN2, MPO
10	creatinine32	10.6	VWF, GC, SELL, SELP, SERPINA1, SERPINA3
11	estradiol32 9 18 9	13.5	GC, SERPINE1, SERPINA3, LEPR, MMP13, AREG
12	allergens32	10.5	SFTPD, CD69, IL10, IL13, IL18, IL4
13	agar32	10.5	RARA, LACTB, CDKN2A, FGF2, CAV1, TXN
14	adenylate32	10.4	PDE4A, VWF, GC, SELP, SERPINE1, VIP
15	morphine32 9 9	12.4	VIP, YY1, IL5, MAPK10, CCL4, CCR3
16	pgd232	10.4	S100A7, ITGAM, IL13, IL5, CCL11, CCR3
17	chloramphenicol32 9 9	12.4	SFTPB, GC, SERPINE1, VDR, MYOD1, RARA
18	polysaccharide32	10.2	SFTPD, SELL, SELP, SELPLG, SERPINE2, SERPINA1
19	pravastatin32 34 9 18 9	14.2	PIK3C2A, SELP, SERPINE1, IL18, IL6, CCL2
20	salmeterol32 42 9 9	13.2	PDE4A, IL13, IL2, IL4, IL5, IL8
21	fluvastatin32 34 9 9	13.2	PIK3C2A, VWF, SELP, SERPINE1, MMP1, MMP9
22	betacarotene32	10.1	VWF, SERPINA3, VDR, RARA, LEP, LCN1
23	fluticasone propionate32 42 9 9	13.0	BGLAP, MPO, MMP9, IL13, IL1B, IL4
24	lactate32	10.0	PIK3C2A, VWF, SFTPD, SELL, SELP, VIP
25	matrigel32	10.0	VWF, SERPINE1, BSG, VEGFA, BMP6, KDR
26	homocysteine32 18	10.9	PIK3C2A, VWF, SELP, SERPINE1, LBP, IL18
27	sulforaphane32	9.7	PARP1, JUN, CDKN1A, GSTM1, GSTP1, MAPK14
28	folate32	9.6	VWF, SERPINA3, VDR, RARA, KDR, UNG
29	retinoid32	9.4	SFTPB, SELL, VDR, BMP6, RARA, CHUK
30	estrogen32	9.4	VWF, GC, SERPINA1, SERPINE1, SERPINA3, VIP
31	imiquimod32 42 9 9	12.3	BMP6, IL10, IL18, IL1RAPL2, IL5, IL6
32	8-isoprostane32	9.2	SERPINE1, LEP, XDH, MPO, MMP2, MMP9
33	polyinosinic-polycytidylic acid32	9.2	IL10, IL18, IL2, IL4, IL5, IL6
34	glycerol32 9 18 9	12.1	PIK3C2A, PDE4A, VWF, LEP, CHUK, CFTR
35	gf 109203x32 42	10.0	VEGFA, CHRM3, CFTR, JUN, CDKN1A, MMP1
36	candesartan32 9 9	11.0	SELP, SERPINE1, VEGFA, MMP1, MMP2, CCL2
37	ribavirin32 34 9 9	11.9	VIPR1, LEP, MMP1, MMP2, MMP9, IL10
38	il-1232	8.8	IL10, IL13, IL18, IL1B, IL2, IL4
39	il 1032	8.3	VDR, BMP6, LBP, IL10, IL10RA, IL13
40	lactacystin32	8.3	VDR, MYOD1, PARP1, BCL2, JUN, CDKN1A
41	gm-csf32	8.3	VEGFA, BMP6, IL10, IL13, IL18, IL1B
42	butyrate32	8.1	VDR, MYOD1, BMP6, RARA, BCL2, LEP
43	herbimycin a32 42	9.0	SELL, BMP6, JUN, CD69, CD4, MMP1
44	methotrexate32 34 42 9 9	12.0	PIK3C2A, SERPINE1, SERPINA3, BMP6, LEP, MUC5AC
45	thyroxine32 18	9.0	PIK3C2A, VWF, GC, SERPINA3, VIP, VDR
46	paraffin32	7.8	RELA, VWF, SFTPB, SELL, SERPINA1, SERPINA3
47	wortmannin32 42	8.7	PIK3C2A, PDE4A, MYLK3, KDR, BCL2, LEP
48	quercetin32 42 9 18 9	11.3	PIK3C2A, PARP1, BCL2, CHUK, BAX, XDH
49	actinomycin d32	5.4	PDE4A, SFTPB, SERPINE2, SERPINE1, VIPR1, VEGFA
50	genistein32 9 18 9	7.6	SELL, SELP, SERPINE1, VEGFA, VDR, PARP1

Cellular components related to copd according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	11.5	AGER, ABCC1, LTB4R, PLAUR, CRHR1, CTLA4
2	external side of plasma membrane	GO:009897	10.1	ADA, IL4, IL1RL1, IL13, FGB, ITGAE
3	plasma membrane	GO:005886	10.1	PLAU, PLAUR, PLCE1, NOS3, NFE2L2, LTB4R
4	cell surface	GO:009986	10.0	PLAUR, ABCB1, ELANE, TLR2, TIMP2, TGFB1
5	secretory granule	GO:030141	9.6	DBH, TF, HCRT, ELANE, CTSG, CYBA
6	platelet alpha granule lumen	GO:031093	9.4	PPBP, TIMP1, TGFB1, KNG1, HGF, ALDOA
7	cytosol	GO:005829	8.6	TXN, TP53, TPI1, TNNT2, PTEN, PPIA
8	extracellular region	GO:005576	8.5	CAMP, IL5, IL2, IL1R2, IL1B, IL18
9	extracellular space	GO:005615	7.3	CRP, CCL5, CCL13, CCL18, CCL3, CCR3

Biological processes related to copd according to GeneDecks:

(show top 50)    (show all 58)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemotaxis	GO:006935	10.9	CCL11, CCR3, CCL3, CCL18, CCL13, CCL5
2	response to lipopolysaccharide	GO:032496	10.9	ELANE, TLR4, TAC1, DCN, CXCL10, ADM
3	cellular response to tumor necrosis factor	GO:071356	10.8	HAS2, SIRT1, EDN1, HYAL2, HYAL1, ICAM1
4	cellular response to interleukin-1	GO:071347	10.8	CCL2, IL8, MMP9, MYLK3, RELA, CCL3
5	extracellular matrix disassembly	GO:022617	10.8	MMP13, MMP2, MMP8, MMP9, CTSG, ELANE
6	response to oxidative stress	GO:006979	10.7	PTGS1, NFKB1, ABCC1, TLR4, OGG1, SIRT1
7	negative regulation of growth of symbiont in host	GO:044130	10.7	TLR2, ELANE, LTA, CTSG, TNF, CAMP
8	defense response to Gram-negative bacterium	GO:050829	10.5	TLR4, NOS2, CAMP, IL6, CD4, S100A7
9	immune response	GO:006955	10.5	IL13, IL18, IL1R2, IL1RL1, IL2, IL2RA
10	response to hyperoxia	GO:055093	10.4	EPO, NOS3, CAT, ALOX5, IL18, MMP9
11	positive regulation of angiogenesis	GO:045766	10.3	CCL5, HYAL1, HMOX1, TNFRSF1A, NOS3, ADM
12	lipopolysaccharide-mediated signaling pathway	GO:031663	10.3	STAT1, CCL3, CCL5, TNF, NOS3, HCK
13	small molecule metabolic process	GO:044281	10.2	CYP2A6, CYP1A2, CYP1A1, PTGS1, PTGS2, PTEN
14	positive regulation of vasodilation	GO:045909	10.2	ADM, ADRB2, NOS3, NOS1, HMOX1, CALCA
15	embryo implantation	GO:007566	10.2	EPO, SOD1, PTGS2, CALCA, IL1B, MMP9
16	regulation of blood pressure	GO:008217	10.2	HBB, TAC1, SOD1, SOD2, NPPA, NPPB
17	inflammatory response	GO:006954	10.2	CXCR2, NPPB, KNG1, HDAC9, CXCR1, CXCL9
18	aging	GO:007568	10.0	EPO, ADRB1, ADA, ADM, VDR, UCP3
19	response to activity	GO:014823	10.0	TLR4, BGLAP, UCP3, IL10, ANGPT2, CCL2
20	cell adhesion	GO:007155	10.0	ICAM1, CCR3, CCL11, CCL2, CCL4, TNC
21	positive regulation of apoptotic process	GO:043065	10.0	PTGS2, CTLA4, NOS3, TLR4, SOD1, SIRT1
22	positive regulation of interleukin-8 production	GO:032757	9.9	ADIPOQ, TLR4, TLR2, CALCA, IL1B, IL18
23	positive regulation of smooth muscle cell proliferation	GO:048661	9.9	STAT1, ELANE, EDN1, PTGS2, TNF, HMOX1
24	cell surface receptor signaling pathway	GO:007166	9.9	AGER, PRL, CXCL10, CXCR1, CXCR2, NPPB
25	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.9	NLRP3, NFKB1, AGER, TLR2, TLR4, TGFB1
26	angiogenesis	GO:001525	9.9	HSPB1, HMOX1, PTEN, NRP1, NOS3, CXCR3
27	response to radiation	GO:009314	9.9	OGG1, SERPINE2, BCL2, JUN, MMP9, IL18
28	response to glucocorticoid stimulus	GO:051384	9.8	SERPINE1, SFTPB, BGLAP, UCP3, ADIPOQ, ADM
29	signal transduction	GO:007165	9.8	CHRNA5, EPO, ADM, ADCY1, PGF, CXCR2
30	cellular response to lipopolysaccharide	GO:071222	9.8	TLR4, NOS2, TNFRSF1B, ICAM1, IFNG, CCL2
31	platelet degranulation	GO:002576	9.8	SERPINE1, VEGFA, CD63, FGB, IGF1, ALB
32	cell-cell signaling	GO:007267	9.7	SFRP2, VIPR2, AVP, INS, IL10, IL13
33	response to hypoxia	GO:001666	9.6	SOD3, NPPB, PGF, ADM, ADA, ADIPOQ
34	response to ethanol	GO:045471	9.6	ADIPOQ, SOD1, TLR4, NOS3, TNFRSF1A, ICAM1
35	platelet activation	GO:030168	9.6	SRF, PPIA, PPBP, TIMP1, TGFB1, TF
36	response to estrogen stimulus	GO:043627	9.5	HMOX1, TNFRSF11B, PPARG, EPO, GATA4, CAV1
37	elevation of cytosolic calcium ion concentration	GO:007204	9.5	HCRT, TAC1, CXCR3, KNG1, ADM, EDN1
38	innate immune response	GO:045087	9.5	F2RL1, TXN, CYBA, PPARG, NLRP3, NFKB1
39	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.4	F2RL1, CAT, NEDD4, HGF, IGF1, CCL5
40	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	IL1B, IFNG, ICAM1, TNF, PTGS2, EDN1
41	blood coagulation	GO:007596	9.3	KNG1, SERPINE1, BSG, VEGFA, CD63, ITGAM
42	negative regulation of cell growth	GO:030308	9.1	TP53, PPARG, TGFB1, NPPA, NPPB, SIRT1
43	response to heat	GO:009408	9.1	NOS3, NOS1, CALCA, CCL2, IL1B, MMP9
44	negative regulation of cell proliferation	GO:008285	8.9	SRF, PTGS2, PTEN, TNF, TP53, NOS3
45	positive regulation of cell proliferation	GO:008284	8.9	INS, FGF2, IL2, IL6, IGF1, PTEN
46	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.3	HGF, ADIPOQ, TLR4, NRP1, TP53, IGF1
47	response to drug	GO:042493	8.2	PTGS2, PPARG, NOS3, LTA, EDN1, ABCB1
48	anti-apoptosis	GO:006916	8.2	CCL2, ANXA5, IL2, IL1B, IL10, GSTP1
49	negative regulation of apoptotic process	GO:043066	7.7	HCK, RELA, SERPINE1, VEGFA, KDR, CASP3
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.7	NOS1, PPARG, SRF, TNFRSF1A, TNF, TP53

Molecular functions related to copd according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	10.9	CCL5, PPBP, CXCL10, CXCL11, CXCL9, CCL13
2	receptor binding	GO:005102	10.7	TNC, HLA-B, CAV1, CALCA, CAT, NOS2
3	heparin binding	GO:008201	10.1	CTSG, NRP1, ELANE, SOD3, PGF, KNG1
4	heme binding	GO:020037	9.9	CYBA, NOS1, NOS2, NOS3, HBB, EPX
5	enzyme binding	GO:019899	9.2	PPARG, PLAUR, PLCE1, EGFR, TGFB1, STAT1
6	protease binding	GO:002020	9.0	CSTA, ELANE, TNFRSF1A, TNF, TP53, INS
7	hormone activity	GO:005179	8.9	ADIPOQ, ADM, NPPB, NPPA, PRL, EDN1
8	protein homodimerization activity	GO:042803	8.6	NOS2, CRP, NR3C1, SRF, PTGS2, HMGCR
9	cytokine activity	GO:005125	8.5	IL6, IL5, IL4, IL2, IL1B, IL18
10	growth factor activity	GO:008083	8.1	IL6, IGF1, PPBP, TGFB1, CSF2, CSF3
11	protein binding	GO:005515	6.4	PTEN, TLR4, TLR2, AGER, HCK, HBB