Summaries for Cor Pulmonale

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MalaCards based summary: Cor Pulmonale, also known as chronic pulmonary heart disease, is related to pulmonary hypertension and congestive heart failure. An important gene associated with Cor Pulmonale is NPPB (natriuretic peptide B), and among its related pathways are Human Embryonic Stem Cell Pluripotency and Cardiomyocyte Differentiation through BMP Receptors. The compounds darusentan and tezosentan have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Cor Pulmonale

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Sources:
62UMLS, 12DISEASES, 45Novoseek
See all sources

Cor Pulmonale, Aliases & Descriptions:

Name: Cor Pulmonale 12 45
 
Chronic Pulmonary Heart Disease 62


Related Diseases for Cor Pulmonale

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Graphical network of the top 20 diseases related to Cor Pulmonale:



Diseases related to cor pulmonale

Symptoms for Cor Pulmonale

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Drugs & Therapeutics for Cor Pulmonale

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Drug clinical trials:

Search ClinicalTrials for Cor Pulmonale

Search NIH Clinical Center for Cor Pulmonale

Genetic Tests for Cor Pulmonale

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Anatomical Context for Cor Pulmonale

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MalaCards organs/tissues related to Cor Pulmonale:

33
Heart, Lung, Brain, Testes, Tonsil, Liver, Breast, Skin, Prostate

Animal Models for Cor Pulmonale or affiliated genes

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MGI Mouse Phenotypes related to Cor Pulmonale:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6SLC4A1, NPPA, EDN1
2MP:00053698.1SLC4A1, NPPB, NPPA, EDN1
3MP:00053857.9EDN1, NPPA, NPPB, SLC4A1

Publications for Cor Pulmonale

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Articles related to Cor Pulmonale:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Paroxysmal atrial fibrillation and clinically reversible cor pulmonale in a horse with complicated recurrent airway obstruction. (25799435)
2015
2
Assessment of the right and left ventricular function in patients with cor pulmonale using high-definition CT. (24112156)
2013
3
Cor pulmonale in a case of infantile Gaucher's disease. (21731876)
2011
4
Cor pulmonale in a patient with Brown-Vialetto-Van Laere syndrome: a case report. (21055769)
2011
5
A rare case of cor pulmonale secondary to idiopathic pulmonary fibrosis in Nigeria. (22693190)
2011
6
Echocardiography of isolated subacute left heart tamponade in a patient with cor pulmonale and circumferential pericardial effusion. (20630052)
2010
7
Cor pulmonale. (19643833)
2009
8
Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease. (18174543)
2008
9
Fatal acute cor pulmonale due to portopulmonary hypertension in a noncirrhotic patient. (18793380)
2008
10
Elevated plasma brain natriuretic peptide levels in chronic respiratory failure with cor pulmonale. (10464838)
1999
11
Relationship between plasma endothelin, nitric oxide, calcitonin gene-related peptide levels and pulmonary hemodynamics in patients with chronic cor pulmonale]. (11326879)
1998
12
Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale. (9059545)
1997
13
Cor pulmonale and silicosis: a necropsy based case-control study. (8329320)
1993
14
Alcohol and cor pulmonale in chronic bronchitis and emphysema. (8461684)
1993
15
Cor pulmonale subacute and recurrent erythema nodosum leprosum. (8464323)
1993
16
Congenital acquired immunodeficiency syndrome presenting as cor pulmonale in a 10-year-old girl. (2000766)
1991
17
Etiology of cor pulmonale. (2391736)
1990
18
Evaluation of the safety and efficacy of amrinone in chronic obstructive lung disease with cor pulmonale. (2316304)
1990
19
Cor pulmonale in an Angus cow. (2590140)
1989
20
The effect of six months of daily treatment with the beta-2 agonist oral pirbuterol on pulmonary hemodynamics in patients with chronic hypoxic cor pulmonale receiving long-term oxygen therapy. (2563321)
1989
21
Cor pulmonale due to tumor cell microemboli. Report of a case with occult gastric carcinoma. (2845876)
1988
22
Long term follow-up of domiciliary oxygen therapy in hypoxic cor pulmonale associated with chronic obstructive airways disease. (3690041)
1987
23
Noninvasive method to assess cor pulmonale in patients with chronic obstructive pulmonary disease. (2954775)
1987
24
Spontaneous rupture of the bladder in a patient with cor pulmonale presenting as acute abdominal emergency. (3748942)
1986
25
Hemodynamic effect of hydralazine in interstitial lung disease patients with cor pulmonale. Immediate and short-term evaluation at rest and during exercise. (3987368)
1985
26
Unilateral calcified fibrothorax with cor pulmonale: failure to improve with decortication. (6867770)
1983
27
Subacute cor pulmonale in hypersensitivity pneumonitis. A case report. (7135142)
1982
28
Scoliosis and cor pulmonale. (7135067)
1982
29
Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. (6110912)
1981
30
Left ventricular volumetry and function in chronic cor pulmonale. (7249663)
1981
31
Acute cor pulmonale resulting from tumor microembolism. (7376655)
1980
32
Management of patients with cor pulmonale. (431194)
1979
33
Pulmonary tuberculosis and cor pulmonale. (731047)
1978
34
Electrocardiographic reversion of acute cor pulmonale on long-term oxygen therapy. (609990)
1977
35
Sex differences in chronic cor pulmonale in delhi. (990163)
1976
36
Editorial: Oedema in cor pulmonale. (54804)
1975
37
Nursing care study: chronic bronchitis, emphysema and cor pulmonale. (1196907)
1975
38
Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. (1173819)
1975
39
Anti-heart antibodies in patients with chronic cor pulmonale. (1121059)
1975
40
Acute respiratory insufficiency and cor pulmonale. Pathophysiology, clinical features, and management. II. Management. (4152189)
1974
41
Present status of treatment of chronic cor pulmonale with congestive failure. (4147007)
1973
42
Left ventricular function, metabolism, and blood flow in chronic cor pulmonale. (4572384)
1973
43
The pathophysiology of the pulmonary circulation in cor pulmonale. (5084597)
1972
44
Respiratory function and right heart haemodynamics in chronic cor pulmonale. (5122798)
1971
45
A dynamic electrocardiographic concept useful in the diagnosis of cor pulmonale. Result of a survey of 200 patients with chronic obstructive pulmonary disease. (4249377)
1970
46
A clinical study of chronic cor pulmonale in Northern India. (5370718)
1969
47
ACUTE COR PULMONALE AND SHOCK. (14348043)
1965
48
The mechanisms of chronic pulmonary heart disease (cor pulmonale), with and without arterial hypoxemia. (13623896)
1959
49
L'noradrenaline in treatment of acute cor pulmonale. (13269845)
1955
50
Pulmonary embolism with acute cor pulmonale and extremely rapid ventricular rate in a young, active apparently healthy adult. (15395458)
1949

Variations for Cor Pulmonale

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Expression for genes affiliated with Cor Pulmonale

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Search GEO for disease gene expression data for Cor Pulmonale.

Pathways for genes affiliated with Cor Pulmonale

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Pathways related to Cor Pulmonale according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2NPPB, NPPA
29.2NPPB, NPPA
39.1NPPA, EDN1
48.7NPPB, NPPA, EDN1

Compounds for genes affiliated with Cor Pulmonale

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Compounds related to Cor Pulmonale according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1darusentan45 3010.8EDN1, NPPB
2tezosentan459.8EDN1, NPPB
3bosentan45 1310.6EDN1, NPPB
4p00035459.6NPPA, NPPB
5hncs459.6NPPA, NPPB
6candoxatril45 1310.5NPPB, NPPA
7alacepril459.5NPPB, NPPA
8imidapril45 5110.5NPPB, NPPA
9toki-shakuyaku-san459.5NPPA, EDN1
10bisoprolol45 51 1311.4NPPA, NPPB
11bq12345 3010.4NPPA, EDN1
12cilazapril45 1310.3EDN1, NPPA
13moxonidine459.3NPPA, NPPB
14isosorbide dinitrate45 51 1311.3EDN1, NPPA
15ly 83583459.3NPPA, NPPC
16fosinopril45 1310.3NPPA, NPPB
17dobutamine45 30 51 1312.2NPPA, NPPB
18quinapril45 51 1311.1NPPA, EDN1
19carbachol45 30 1311.1NPPC, NPPB, EDN1
20trandolapril45 1310.1EDN1, NPPA, NPPB
21enalaprilat459.1EDN1, NPPA, NPPB
22enalapril45 51 1311.1EDN1, NPPA, NPPB
23carvedilol45 51 30 1312.1NPPB, NPPA, EDN1
24phosphoramidon45 1310.1NPPB, NPPA, EDN1
25sildenafil30 45 51 26 1313.1EDN1, NPPA, NPPB
26nitroglycerin45 1310.1NPPB, NPPA, EDN1
27furosemide45 61 30 51 26 1314.1NPPA, NPPB, SLC4A1
28captopril45 61 51 30 1313.0NPPB, NPPA, EDN1
29ang ii459.0NPPB, NPPA, EDN1
30losartan45 51 30 1312.0NPPB, NPPA, EDN1
318-bromo cgmp459.0NPPA, NPPB, NPPC
32omapatrilat459.0EDN1, NPPA, NPPC
33thiorphan45 30 1310.9EDN1, NPPA, NPPC
34iberiotoxin45 61 3010.9NPPA, NPPC
35ng-nitro-l-arginine458.9NPPC, NPPA, EDN1
36guanylate458.9NPPC, NPPB, NPPA
37urodilatin458.5NPPC, NPPB, NPPA, EDN1
38hanp458.5EDN1, NPPA, NPPB, NPPC
39s-nitroso-n-acetylpenicillamine458.5EDN1, NPPA, NPPB, NPPC
40l-nmma458.5NPPC, NPPB, NPPA, EDN1
41phenylephrine45 30 26 1311.5EDN1, NPPA, NPPB, NPPC
42sodium nitroprusside458.5NPPC, NPPB, NPPA, EDN1
43cgmp45 309.5NPPC, NPPB, NPPA, EDN1
44isoproterenol45 139.5NPPC, NPPB, NPPA, EDN1
45prostacyclin458.5EDN1, NPPA, NPPB, NPPC
46norepinephrine45 26 1310.4NPPC, NPPB, NPPA, EDN1
47creatinine458.4EDN1, NPPA, NPPB, NPPC
48chloride458.2SLC4A1, NPPC, NPPA
49sodium45 269.0EDN1, NPPA, NPPB, NPPC, SLC4A1
50nitric oxide45 26 139.9EDN1, NPPA, NPPB, NPPC, SLC4A1

GO Terms for genes affiliated with Cor Pulmonale

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Cellular components related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1NPPC, NPPB, NPPA, EDN1

Biological processes related to Cor Pulmonale according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1body fluid secretionGO:00075899.6EDN1, NPPB
2positive regulation of urine volumeGO:00358109.6NPPB, EDN1
3positive regulation of renal sodium excretionGO:00358159.5NPPB, EDN1
4cell surface receptor signaling pathwayGO:00071669.5NPPB, EDN1
5regulation of blood pressureGO:00082179.1NPPA, NPPB
6negative regulation of cell growthGO:00303088.9NPPB, NPPA
7cGMP biosynthetic processGO:00061828.8NPPC, NPPB, NPPA
8receptor guanylyl cyclase signaling pathwayGO:00071688.8NPPC, NPPB, NPPA
9regulation of blood vessel sizeGO:00508808.8NPPA, NPPB, NPPC
10response to hypoxiaGO:00016668.7NPPC, NPPA, EDN1

Molecular functions related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:00514288.7NPPC, NPPA
2receptor bindingGO:00051028.6NPPC, NPPB, NPPA
3hormone activityGO:00051798.0NPPC, NPPB, NPPA, EDN1

Products for genes affiliated with Cor Pulmonale

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Sources for Cor Pulmonale

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet