MCID: CRP018
MIFTS: 36

Cor Pulmonale malady

Summaries for Cor Pulmonale

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cor pulmonale (Latin cor, heart + New Latin pulmōnāle, of the lungs), also known as pulmonary heart... more...

MalaCards: Cor Pulmonale, also known as chronic pulmonary heart disease, is related to acute cor pulmonale and hypertension. An important gene associated with Cor Pulmonale is NPPB (natriuretic peptide B), and among its related pathways are melatonin degradation II and Methionine salvage pathway. The compounds norepinephrine and isoproterenol have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are muscle and hematopoietic system.

Aliases & Classifications for Cor Pulmonale

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60UMLS, 10DISEASES, 44Novoseek
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Aliases & Descriptions:

cor pulmonale 10 44
chronic pulmonary heart disease 60


Related Diseases for Cor Pulmonale

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17GeneCards, 18GeneDecks
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Diseases related to Cor Pulmonale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1acute cor pulmonale31.6PDZK1IP1
2hypertension31.2REN, AGTR1, EDN1, NPPA, NPPC, NPPB
3pulmonary embolism31.2NPPB, SERPINC1
4cystic fibrosis30.9NPPC
5respiratory failure30.9SLC4A1, SERPINC1
6pneumonia30.6MB
7pulmonary fibrosis30.6AGTR1, EDN1, SOD1
8asthma30.6NPPC, EDN1, GPX3
9myocardial infarction30.6MB, NPPB, NPPC, NPPA, EDN1, AGER
10congestive heart failure30.5REN, NPPC
11sickle cell disease30.4EDN1
12vascular disease30.4SOD1, NPPC, EDN1, AGER, AGTR1, SERPINC1
13coronary artery disease30.4MB, NPPB, NPPC, NPPA, EDN1, AGER
14glomerulonephritis30.2AGTR1
15obesity30.2AGER
16anuria30.2MB
17hypertensive heart disease30.2AGTR1, NPPA, NPPB
18primary pulmonary hypertension30.2NPPB, NPPA, EDN1
19arthritis30.2AGTR1, AGER, MB
20breast cancer30.2SMOX, GPX3
21myopathy30.2SEPN1, MB
22atherosclerosis30.1SOD1, MB, NPPC, EDN1, AGER, AGTR1
23bronchitis10.6
24obstructive lung disease10.6
25pulmonary tuberculosis10.5
26tuberculosis10.5
27adenoiditis10.5
28nasopharyngitis10.4
29pulmonary alveolar microlithiasis10.4
30tonsillitis10.4
31chronic pulmonary heart disease10.4
32interstitial lung disease10.4
33pericardial effusion10.4
34pulmonary emphysema10.4
35sarcoidosis10.4
36cardiac tamponade10.3
37ankylosing spondylitis10.3
38patent foramen ovale10.3
39pulmonary edema10.3
40hemosiderosis10.3
41homocystinuria10.3
42acquired immunodeficiency syndrome10.3
43silicosis10.3
44pycnodysostosis10.3
45mediastinitis10.3
46neuromuscular disease10.3
47polycythemia10.3
48spondylitis10.3
49burns10.1
50niemann-pick disease10.1

Graphical network of the top 20 diseases related to Cor Pulmonale:



Diseases related to cor pulmonale

Clinical Features for Cor Pulmonale

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Drugs & Therapeutics for Cor Pulmonale

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Cor Pulmonale

Search NIH Clinical Center for Cor Pulmonale

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Genetic Tests for Cor Pulmonale

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Anatomical Context for Cor Pulmonale

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32MalaCards
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MalaCards organs/tissues related to Cor Pulmonale:

32
Heart, Lung

Animal Models for Cor Pulmonale or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cor Pulmonale:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7SEPN1, SLC4A1, REN, AGER, EDN1, NPPA
2MP:00053978.5SERPINC1, SOD1, NPPA, AGER, REN, RNF128
3MP:00053678.5NPPA, EDN1, AGER, REN, GPX3, AGTR1
4MP:00053858.1SERPINC1, SOD1, MB, NPPB, NPPA, PHOX2B
5MP:00053767.9RNF128, REN, AGTR1, AGER, EDN1, PHOX2B

Publications for Cor Pulmonale

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Genetic Variations for Cor Pulmonale

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Expression for genes affiliated with Cor Pulmonale

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cor Pulmonale

Search GEO for disease gene expression data for Cor Pulmonale.

Pathways for genes affiliated with Cor Pulmonale

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Cor Pulmonale according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8SMOX, PAOX
2
Hide members
9.8SMOX, PAOX
39.8SEPN1, GPX3, SOD1

Compounds for genes affiliated with Cor Pulmonale

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cor Pulmonale according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5NPPC, MB
2isoproterenol44 1111.5AGTR1, NPPC
3captopril44 28 49 59 1114.5EDN1, REN
4toki-shakuyaku-san4410.3NPPA, EDN1, REN
5alacepril4410.2REN, NPPA, NPPB
6omapatrilat4410.2NPPC, NPPA, EDN1, REN
7cilazapril44 1111.2NPPA, EDN1, AGTR1, REN
8trimetazidine4410.2SOD1, MB, EDN1
9enalaprilat4410.2NPPB, NPPA, EDN1, REN
10darusentan44 2811.1NPPB, EDN1, REN
11fosinopril44 1111.1NPPB, NPPA, AGTR1, REN
12ng-nitro-l-arginine4410.1SOD1, NPPC, NPPA, EDN1
13lisinopril44 11 2412.1NPPB, NPPA, AGTR1, REN
14quinapril44 1111.1NPPA, EDN1, AGTR1, REN
15valsartan44 59 28 1113.1REN, AGTR1, EDN1, NPPB
16ramipril44 1111.1NPPB, NPPA, AGTR1, REN
17s-nitroso-n-acetylpenicillamine4410.1EDN1, NPPA, NPPC, NPPB, SOD1
18perindopril44 49 1112.1NPPB, NPPA, AGTR1, REN
19urodilatin4410.1NPPB, NPPC, NPPA, EDN1, REN
20hanp4410.1NPPB, NPPC, NPPA, EDN1, REN
21telmisartan44 28 1112.0NPPB, AGER, AGTR1, REN
22trandolapril44 1111.0NPPB, NPPA, EDN1, AGTR1, REN
23phenylephrine44 28 11 2413.0NPPB, NPPC, NPPA, EDN1, AGTR1
24enalapril44 49 1112.0NPPB, NPPA, EDN1, AGTR1, REN
25carvedilol44 49 28 1113.0NPPB, NPPA, EDN1, AGTR1, REN
26oxygen44 2411.0SMOX, PAOX, MB
27ang ii4410.0NPPB, NPPA, EDN1, AGTR1, REN
28furosemide44 49 59 28 11 2415.0NPPB, NPPA, AGTR1, REN, SLC4A1
29lacidipine4410.0EDN1, AGTR1, REN
30candesartan44 28 1112.0NPPB, AGER, AGTR1, REN
31l-nmma449.9SOD1, NPPB, NPPC, NPPA, EDN1, AGTR1
32diltiazem44 28 1111.9EDN1, AGTR1, REN, SERPINC1
338-isoprostane449.9SOD1, NPPB, EDN1, AGTR1, GPX3
34amlodipine44 49 11 2412.9NPPB, NPPA, AGTR1, REN
35losartan44 49 28 1112.9NPPB, NPPA, EDN1, AGTR1, REN
36spironolactone49 44 59 28 1113.9NPPB, NPPA, AGTR1, REN
37heparin44 28 11 2412.9GPX3, AGER, A2M, MB
38nitroglycerin44 1110.9SOD1, NPPB, NPPA, EDN1, AGTR1, REN
39cgmp44 2810.8NPPB, NPPC, NPPA, EDN1, AGTR1, REN
40uric acid44 2410.7SOD1, NPPB, AGER, AGTR1, GPX3
41haloperidol44 28 2 49 1113.7MB, NPPB, NPPA, AGTR1, REN
42sodium nitroprusside449.5SOD1, MB, NPPB, NPPC, NPPA, EDN1
43dopamine44 28 11 2412.4MB, NPPB, PHOX2B, AGER, AGTR1, REN
44epinephrine44 11 2411.4MB, NPPB, NPPA, EDN1, AGTR1, REN
45prostacyclin449.3SERPINC1, SOD1, NPPB, NPPC, NPPA, EDN1
46sodium44 2410.2NPPB, NPPC, NPPA, EDN1, AGTR1, REN
47nitric oxide44 11 2411.0SOD1, NPPB, NPPC, NPPA, EDN1, AGER
48arginine448.9MB, NPPB, NPPA, EDN1, AGTR1, REN
49creatinine448.7SOD1, MB, NPPB, NPPC, NPPA, EDN1
50vegf448.6MB, NPPB, NPPA, EDN1, AGER, AGTR1

GO Terms for genes affiliated with Cor Pulmonale

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16Gene Ontology
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Cellular components related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6SOD1, NPPB, NPPC, NPPA, A2M, EDN1
2extracellular spaceGO:0056158.3SOD1, NPPB, NPPC, NPPA, A2M, EDN1

Biological processes related to Cor Pulmonale according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1body fluid secretionGO:00758910.3EDN1, NPPB
2cGMP biosynthetic processGO:00618210.3NPPA, NPPC, NPPB
3receptor guanylyl cyclase signaling pathwayGO:00716810.3NPPB, NPPA, NPPC
4regulation of blood vessel sizeGO:05088010.3NPPB, NPPC, NPPA
5regulation of vasodilationGO:04231210.3AGTR1, NPPB
6regulation of vasoconstrictionGO:01922910.3NPPC, EDN1, AGTR1
7renin-angiotensin regulation of aldosterone productionGO:00201810.3REN, AGTR1
8positive regulation of urine volumeGO:03581010.2NPPB, EDN1
9elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.2AGTR1, EDN1
10polyamine catabolic processGO:00659810.1SMOX, PAOX
11spermine catabolic processGO:04620810.1SMOX, PAOX
12superoxide anion generationGO:04255410.0SOD1, EDN1
13polyamine biosynthetic processGO:00659610.0SMOX, PAOX
14regulation of blood pressureGO:0082179.9NPPB, NPPC, NPPA, REN, SOD1
15positive regulation of renal sodium excretionGO:0358159.9NPPB, EDN1
16polyamine metabolic processGO:0065959.8PAOX, SMOX

Molecular functions related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.2NPPA, NPPC
2hormone activityGO:0051799.9NPPC, NPPB, NPPA, EDN1
3spermine:oxygen oxidoreductase (spermidine-forming) activityGO:0529019.7SMOX, PAOX
4polyamine oxidase activityGO:0465929.5PAOX, SMOX
5receptor bindingGO:0051029.5PAOX, NPPB, NPPC, NPPA, REN

Products for genes affiliated with Cor Pulmonale

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  • Antibodies
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Sources for Cor Pulmonale

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet