Search MalaCards:
MCID: CRP018

Cor Pulmonale malady
26 genes, 3 tissues, 364 related diseases, 9 phenotypes, 31 articles, clinical trials.

Summaries for Cor Pulmonale

about this section
Sources:
44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
Wikipedia: Cor pulmonale (Latin cor, heart + New Latin pulmōnāle, of the lungs) or pulmonary heart disease is...44 more...

MalaCards: Cor Pulmonale, also known as chronic pulmonary heart disease, is related to acute cor pulmonale and pulmonary hypertension. An important gene associated with Cor Pulmonale is NPPB (natriuretic peptide B), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Amine Oxidase reactions. The compounds isoproterenol and alacepril have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and heart, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Aliases & Descriptions for Cor Pulmonale

about this section
Sources:
43UMLS, 8DISEASES, 32Novoseek
See all sources
cor pulmonale 8 32
chronic pulmonary heart disease 43

Related Diseases for Cor Pulmonale

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to cor pulmonale by text searches and GeneDecks gene sharing:

(show top 50)    (show all 361)
idRelated DiseaseScoreTop Affiliating Genes
1acute cor pulmonale34.3PIWIL2, PDZK1IP1, NPPB
2pulmonary hypertension32.8EDN1, NPPA, NPPB
3hypertension32.4REN, ACE, AGTR1
4obstructive lung disease29.7REN, CALCA, LTA, ACE, AGER, NPPA
5congestive heart failure28.9REN, EDN1, ACE, AGTR1, NPPA, NPPB
6copd28.4VWF, FGF2, CAT, CALCA, LTA, EDN1
7emphysema28.4FGF2, CALCA, LTA, A2M, EDN1, AGER
8muscular dystrophy27.4VWF, SEPN1, FGF2, MB, ACE, AGER
9chronic obstructive pulmonary disease26.7REN, VWF, PAOX, FGF2, CAT, SMOX
10respiratory failure25.9REN, SERPINC1, SEPN1, PAOX, MB, SMOX
11pulmonary disease25.4REN, VWF, SERPINC1, FGF2, MB, GPX3
12central sleep apnea13.6NPPA, NPPB
13raynaud disease13.6EDN1, AGTR1
14mitral valve stenosis13.5NPPA, NPPB
15mitral valve insufficiency13.5NPPA, NPPB
16congenital heart defect13.5EDN1, NPPA, NPPB
17cerebral arteriosclerosis13.4CALCA, EDN1
18meconium aspiration syndrome13.3PAOX, SMOX, EDN1
19posterior urethral valves13.3ACE, AGTR1
20aortic coarctation13.3EDN1, ACE, AGTR1
21mitral valve disease13.3ACE, AGTR1, NPPA
22chronic rapidly progressive glomerulonephritis13.3ACE, AGTR1, NPPA
23catecholaminergic polymorphic ventricular tachycardia13.2ACE, NPPA, NPPB
24acute kidney tubular necrosis13.2MB, NPPA
25systolic heart failure13.2EDN1, ACE, NPPA, NPPB
26meningitis and encephalitis13.2CAT, SOD1
27diastolic heart failure13.2ACE, AGTR1, NPPA, NPPB
28hypertensive heart disease13.2ACE, AGTR1, NPPA, NPPB
29mesangial proliferative glomerulonephritis13.2FGF2, EDN1, AGTR1
30cardiac sarcoidosis13.2LTA, ACE, NPPB
31low renin hypertension13.2REN, EDN1
32chronic rhinitis13.1CALCA, EDN1
33diabetic angiopathy13.1CAT, EDN1, AGER
34proliferative glomerulonephritis13.1FGF2, EDN1, AGTR1
35familial hypertrophic cardiomyopathy13.1ACE, AGTR1, NPPB
36alzheimer's disease13.1A2M, ACE
37twin-to-twin transfusion syndrome13.1REN, EDN1, NPPA
38twin twin transfusion syndrome13.1REN, EDN1, NPPA
39sudden cardiac death multi-gene panels13.1MB, ACE, NPPB
40enuresis13.1REN, NPPA, NPPB
41focal segmental glomerulosclerosis13.1GPX3, EDN1, ACE, AGTR1
42abcb11-related intrahepatic cholestasis13.1REN, NPPA, NPPB
43acute mountain sickness13.0MB, EDN1, ACE, AGTR1
44aphthous stomatitis13.0CAT, LTA, SOD1
45eisenmenger syndrome13.0VWF, EDN1, ACE
46bacterial meningitis13.0CAT, EDN1, SOD1
47pandas13.0CAT, EDN1, SOD1, NPPA
48hyporeninemic hypoaldosteronism13.0REN, ACE
49retinal detachment13.0FGF2, EDN1, SOD1, NPPA
50familial hypercholesterolemia13.0EDN1, ACE, AGTR1, SOD1, NPPA

Graphical network of the top 20 diseases related to cor pulmonale:



Graphical network of diseases related to cor pulmonale

Clinical Features for Cor Pulmonale

about this section

Drugs & Therapeutics for Cor Pulmonale

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for cor pulmonale

Drug clinical trials:

Search ClinicalTrials for cor pulmonale

Search NIH Clinical Center for cor pulmonale

Search CenterWatch for cor pulmonale

Genetic Tests for Cor Pulmonale

about this section

Anatomical Context for Cor Pulmonale

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to cor pulmonale:

22
Brain, Lung, Heart

Phenotypes for genes affiliated with Cor Pulmonale

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to cor pulmonale:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:00053979.5RNF128, FGF2, MB
2renal/urinary system phenotypeMP:00053679.2GPX3, REN, AGTR1, SLC4A1, NPPA
3skeleton phenotypeMP:00053908.8SEPN1, FGF2, CALCA, NPPC
4muscle phenotypeMP:00053697.7SLC4A1, REN, SEPN1, MB, EDN1, AGER
5nervous system phenotypeMP:00036317.5EDN1, LTA, RNF128, VWF, PHOX2B, REN
6cellular phenotypeMP:00053846.4VWF, ACE, FGF2, MB, CAT, PHOX2B
7mortality/agingMP:00107685.6PHOX2B, FGF2, SERPINC1, VWF, REN, GPX3
8cardiovascular system phenotypeMP:00053855.0REN, SLC4A1, NPPB, NPPA, SOD1, AGTR1
9homeostasis/metabolism phenotypeMP:00053764.2LTA, RNF128, PHOX2B, CALCA, CAT, GPX3

Publications for genes affiliated with Cor Pulmonale

about this section
Sources:
35PubMed
See all sources

Articles related to cor pulmonale:

(show all 31)
idTitleAuthorsYearAffiliating Genes
1Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study. (21450080)Miniati M.... Bottai M.2011AGER
2High plasma brain natriuretic peptide levels in stable COPD without pulmonary hypertension or Cor pulmonale. (19336951)Inoue Y.... Aizawa H.2009NPPB
3Cor pulmonale due to congenital central hypoventilati on syndrome presenting in adolescence. (19584633)Fine-Goulden M.R.... Durward A.2009PHOX2B
4Hartil effects on structural-functional condition of the heart in patients with chronic cor pulmonale (19555040)Krushka S.I.... Tofan E.F.2008ACE
5Pulmonary hypertension and chronic cor pulmonale in COPD. (18229565)Shujaat A.... Eden E.2007NPPB
6Change in serum basic fibroblast growth factor level and its relationship to pulmonary arterial pressure in patients with acute exa cerbation of chronic cor pulmonale on plateau]. (17166351)Yang S.Y.... Zhang Y.2006FGF2
7Clinical efficiency of course and long-term therapy with the angiotensin-converting enzyme inhibitor perindopril in patients with c hronic obstructive lung disease and cor pulmonale (16881230)Butorov I.V.... Maksimov V.V.2006ACE
8Angiotensin converting enzyme activity in the clinical course and forming of cor pulmonale in patients with chronic obstructive pulmonary diseases (16755852)Fedorova T.A.... Rybakova M.K.2006ACE
9Interest of the brain natriuretic peptide as a marker of acute cor pulmonale in acute respiratory distress syndrome (16860526)Thierry S.... Tenaillon A.2006NPPB
10Effects of trimetazidine on lipid peroxidation, antioxidant enzyme activities and plasma brain natriuretic peptide levels in patients with chronic cor pulmonale. (16372578)Bayram E.... YA1cel O.2005CAT, GPX3
11Rigid spine muscular dystrophy due to SEPN1 mutation presenting as cor pulmonale. (15668457)Venance S.L.... Hahn A.F.2005SEPN1
12Use of the ACE inhibitor perindopril in patients wit h chronic obstructive lung diseases, complicated by cor pulmonale (16279041)Vutorov I.V.... Kureker' S.I.2005ACE
13Cardiac troponin I levels in patients with left heart failure and cor pulmonale. (11386382)GA1ler N.... DA1lger H.2001MB
14Elevated plasma brain natriuretic peptide levels in chronic respiratory failure with cor pulmonale. (10464838)Bando M.... Kitamura S.1999NPPB, NPPA
15Effects of ligustrazine on plasma platelet aggregation rate, thromboxane B2, 6-keto-prostaglandin F1 alpha and von Willebrand's factor in patients with acute onset of cor pulmonale (11783174)Wang S.... Ma D.1999VWF
16The change of plasma level of endothelin-1 in patients with cor pulmonale and the effects of Captopril (12212053)Chen W.... Cheng D.1999EDN1
17Relationship between plasma endothelin, nitric oxide, calcitonin gene-related peptide levels and pulmonary hemodynamics in patients with chronic cor pulmonale (11326879)Bai C.... Liu Z.1998CALCA, EDN1
18Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale. (9059545)Kiely D.G.... Lipworth B.J.1997AGTR1
19Changes of plasma endothelium-derived relaxing factor and endothelin-1 in patients with chronic cor pulmonale at exercise test (10072796)Guo S.... Wang C.1997EDN1
20Atrial natriuretic peptide and brain natriuretic peptide in cor pulmonale. Hemodynamic and endocrine effects. (8915224)Cargill R.I.... Lipworth B.J.1996NPPB, NPPA
21Mechanism of plasma endothelin-1 level elevation and its relation with pulmonary hypertension in chronic cor pulmonale (9275630)Zhang J.... Wang C.1996EDN1
22A research of acute hemodynamics and hormonal change s of intravenous captopril in patients with cor pulmonale and pulmonary hyperte nsion (8762486)Tang B.... Huang Y.1995REN, NPPA
23Pulmonary hypertension and cor pulmonale. (9363069)Auger W.R.1995EDN1
24Effect of Salvia miltiorrhiza on lipid peroxidation antioxidant enzymes activity in patients with chronic cor pulmonale (7841755)Zhang P.T.... Chen Z.R.1994SOD1, CAT
25A study on changes of plasma endothelin-1 level in patients with chronic cor pulmonale (7768140)Zhang C.X.... Liu S.X.1994EDN1
26C-type natriuretic peptide levels in cor pulmonale and in congestive heart failure. (7878562)Cargill R.I.... Lipworth B.J.1994NPPB, NPPA, NPPC
27The study on prethrombotic state in patients with chronic obstructive pulmonary disease and cor pulmonale (8221962)Ma D.1993VWF
28Erythrocyte membrane band 3 protein and HCO3-/Cl- exchange function in cor pulmonale patients (1327460)Yang X.1992SLC4A1
29Effects of different administration of Salvia miltiorrhiza and heparin on antithrombin IIIAg, antithrombin III: A and alpha 2-macroglobulin in patients with cor pulmonale (1725279)Zhang F.C.... Zheng L.J.1991SERPINC1, A2M
30Changes in atrial natriuretic peptide concentrations during intravenous saline infusion in hypoxic cor pulmonale. (1837627)Stewart A.G.... Howard P.1991NPPA
31Measurement of plasma malondialdehyde contents and erythrocyte superoxide dismutase activities in patients with chronic cor pulmonale (1819377)Cheng P.1991SOD1

Expression for genes affiliated with Cor Pulmonale

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Cor Pulmonale

Pathways for genes affiliated with Cor Pulmonale

about this section
Sources:
34PharmGKB, 38Reactome, 37R&D Systems, 20KEGG
See all sources

Pathways related to cor pulmonale according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1ACE Inhibitor Pathway, Pharmacodynamics3410.4AGTR1
2Amine Oxidase reactions3810.0PAOX, SMOX
3Pathway_PA165980337349.8CAT, SOD1
4Oxidative Stress Pathway (Erythrocyte)349.7CAT, SOD1
5Oxidative Stress Pathway (Erythrocyte)349.5CAT, SOD1
6Blood Coagulation Signaling Pathways379.4A2M, SERPINC1, VWF
7Renin-angiotensin system209.4REN, ACE, AGTR1
8Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics349.4REN, ACE, AGTR1

Compounds for genes affiliated with Cor Pulmonale

about this section
Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to cor pulmonale according to GeneDecks:

(show top 50)    (show all 203)
idCompoundScoreTop Affiliating Genes
1isoproterenol32 9 9 12.2NPPA, FGF2
2alacepril32 9.9NPPB, REN, NPPA
3urodilatin32 9.6NPPA, NPPC, EDN1, REN, NPPB
4hanp32 9.6REN, EDN1, NPPA, NPPB, NPPC
5trimetazidine32 9.6MB, CAT, EDN1, SOD1
6s-nitroso-n-acetylpenicillamine32 9.5NPPC, CAT, SOD1, EDN1, NPPA, NPPB
78-isoprostane32 9.4AGTR1, NPPB, EDN1, CAT, SOD1, GPX3
8lacidipine32 9.4REN, ACE, EDN1, AGTR1
9omapatrilat32 9.4REN, NPPA, NPPC, EDN1, ACE
10l-nmma32 9.4EDN1, SOD1, AGTR1, NPPA, NPPB, NPPC
11enalaprilat32 9.3NPPA, ACE, NPPB, REN, EDN1
12cilazapril32 9 9 11.3ACE, EDN1, REN, AGTR1, NPPA
13fosinopril32 9 9 11.3NPPB, REN, NPPA, AGTR1, ACE
14lisinopril32 9 18 9 12.3ACE, NPPB, NPPA, AGTR1, REN
15benazepril32 9 9 11.3REN, NPPA, ACE, AGTR1
16valsartan32 42 9 9 12.3AGTR1, ACE, EDN1, REN, NPPB
17ramipril32 9 9 11.3REN, ACE, AGTR1, NPPA, NPPB
18heparin32 9 18 9 12.3A2M, AGER, NPPC, GPX3, AGTR1, VWF
19epinephrine32 9 18 9 12.2MB, AGTR1, NPPB, NPPA, REN
20dobutamine32 9 9 11.2NPPB, NPPA, SERPINC1, FGF2
21ng-nitro-l-arginine32 9.2CALCA, NPPA, EDN1, SOD1, NPPC
22trandolapril32 9 9 11.2ACE, AGTR1, REN, NPPA, EDN1, NPPB
23enalapril32 9 9 11.2NPPB, NPPA, AGTR1, ACE, EDN1, REN
24carvedilol32 34 9 9 12.2ACE, NPPB, NPPA, REN, AGTR1, EDN1
25bisoprolol32 9 9 11.2ACE, NPPB, REN, NPPA, VWF
26ang ii32 9.1NPPB, REN, EDN1, ACE, AGTR1, NPPA
27telmisartan32 9 9 11.1AGTR1, AGER, NPPB, ACE, REN
28spironolactone32 42 34 9 9 13.1ACE, NPPA, NPPB, AGTR1, REN
29thiorphan32 9 9 11.1EDN1, NPPC, CALCA, NPPA, ACE
30candesartan32 9 9 11.0AGTR1, REN, ACE, NPPB, AGER
31oxygen32 18 10.0AGER, AGTR1, NPPA, LTA, MB, GPX3
32moxonidine32 9.0ACE, NPPB, NPPA, REN
33uric acid32 18 10.0AGER, CAT, GPX3, AGTR1, SOD1, NPPB
34quinapril32 9 9 11.0ACE, NPPA, AGTR1, EDN1, VWF, REN
35perindopril32 34 9 9 12.0VWF, ACE, AGTR1, NPPA, REN, NPPB
36digoxin32 42 34 9 18 9 13.9NPPB, NPPA, AGTR1, ACE, REN
37phosphoramidon32 9 9 10.9NPPB, NPPA, ACE, EDN1, CALCA
38losartan32 34 9 9 11.8NPPA, ACE, AGTR1, REN, VWF, NPPB
39captopril32 42 9 9 11.7CALCA, NPPB, NPPA, ACE, REN
40olmesartan32 9 9 10.7REN, AGER, AGTR1, ACE
41furosemide32 42 34 9 18 9 13.4NPPB, NPPA, AGTR1, REN, SLC4A1, ACE
42sodium nitroprusside32 8.0REN, VWF, MB, CAT, EDN1, SOD1
43acetylcholine32 9 18 9 11.0NPPC, NPPB, AGTR1, EDN1, CALCA, MB
44thyroxine32 18 8.5MB, NPPB, VWF, REN, FGF2, LTA
45norepinephrine32 9 18 9 10.3NPPA, AGTR1, ACE, EDN1, MB, PHOX2B
46prostacyclin32 7.2NPPC, NPPB, NPPA, SOD1, AGTR1, AGER
47pge232 7.1REN, MB, SERPINC1, CALCA, FGF2, LTA
48vegf32 6.4VWF, NPPA, REN, SERPINC1, AGTR1, NPPB
49creatinine32 6.3CALCA, GPX3, MB, SERPINC1, VWF, REN
50nitric oxide32 9 18 9 9.1AGER, SOD1, AGTR1, REN, VWF, ACE

GO Terms for genes affiliated with Cor Pulmonale

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to cor pulmonale according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.7NPPC, SERPINC1, SEPN1, FGF2, CALCA, A2M
2extracellular spaceGO:0056155.9NPPC, SERPINC1, FGF2, GPX3, CALCA, LTA

Biological processes related to cor pulmonale according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.2NPPA, NPPC, NPPB
2regulation of blood vessel sizeGO:05088010.1NPPA, NPPB, NPPC
3receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPA, NPPB, NPPC
4spermine catabolic processGO:04620810.0PAOX, SMOX
5polyamine biosynthetic processGO:00659610.0PAOX, SMOX
6regulation of vasodilationGO:0423129.9ACE, NPPB, AGTR1
7regulation of vasoconstrictionGO:0192299.8EDN1, ACE, AGTR1, NPPC
8regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.6ACE, AGTR1
9renin-angiotensin regulation of aldosterone productionGO:0020189.6AGTR1, REN
10elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.4CALCA, EDN1, AGTR1
11response to hypoxiaGO:0016669.0NPPC, CAT, LTA, EDN1, NPPB, MB
12response to drugGO:0424938.9REN, GPX3, LTA, EDN1, SOD1, NPPB
13regulation of blood pressureGO:0082178.2REN, CALCA, ACE, SOD1, NPPA, NPPB

Molecular functions related to cor pulmonale according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.0NPPC, NPPB, NPPA
2bradykinin receptor bindingGO:0317119.9AGTR1, ACE
3spermine:oxygen oxidoreductase (spermidine-forming) activityGO:0529019.9PAOX, SMOX
4polyamine oxidase activityGO:0465929.7SMOX, PAOX
5hormone activityGO:0051799.1NPPC, NPPB, NPPA, EDN1, CALCA
6receptor bindingGO:0051027.6REN, NPPC, NPPB, NPPA, LTA, CALCA

Sources for Cor Pulmonale

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z