MCID: CRP018
MIFTS: 44

Cor Pulmonale malady

Summaries for Cor Pulmonale

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66Wikipedia, 34MalaCards
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Wikipedia:66 Cor pulmonale (Latin cor, heart + New Latin pulm?n?le, of the lungs), also known as pulmonary heart... more...

MalaCards: Cor Pulmonale, also known as chronic pulmonary heart disease, is related to hypertension and congestive heart failure. An important gene associated with Cor Pulmonale is NPPB (natriuretic peptide B), and among its related pathways are Human Embryonic Stem Cell Pluripotency and Cardiomyocyte Differentiation through BMP Receptors. The compounds tezosentan and darusentan have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Cor Pulmonale

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Sources:
63UMLS, 11DISEASES, 46Novoseek
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Aliases & Descriptions:

cor pulmonale 11 46
chronic pulmonary heart disease 63


Related Diseases for Cor Pulmonale

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Cor Pulmonale:



Diseases related to cor pulmonale

Symptoms for Cor Pulmonale

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Drugs & Therapeutics for Cor Pulmonale

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Cor Pulmonale

Search CenterWatch for Cor Pulmonale

Genetic Tests for Cor Pulmonale

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Anatomical Context for Cor Pulmonale

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34MalaCards
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MalaCards organs/tissues related to Cor Pulmonale:

34
Heart, Lung, Brain, Tonsil, Liver, Testes, Breast, Skin, Prostate

Animal Models for Cor Pulmonale or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cor Pulmonale:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6SLC4A1, NPPA, EDN1
2MP:00053698.1SLC4A1, NPPB, NPPA, EDN1
3MP:00053857.9EDN1, NPPA, NPPB, SLC4A1

Publications for Cor Pulmonale

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53PubMed
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Articles related to Cor Pulmonale:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Assessment of the right and left ventricular function in patients with cor pulmonale using high-definition CT. (24112156)
2013
2
Cor pulmonale in a case of infantile Gaucher's disease. (21731876)
2011
3
A rare case of cor pulmonale secondary to idiopathic pulmonary fibrosis in Nigeria. (22693190)
2011
4
Echocardiography of isolated subacute left heart tamponade in a patient with cor pulmonale and circumferential pericardial effusion. (20630052)
2010
5
Cor pulmonale. (19643833)
2009
6
Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease. (18174543)
2008
7
Fatal acute cor pulmonale due to portopulmonary hypertension in a noncirrhotic patient. (18793380)
2008
8
Effects of trimetazidine on lipid peroxidation, antioxidant enzyme activities and plasma brain natriuretic peptide levels in patients with chronic cor pulmonale. (16372578)
2005
9
Echo-Doppler demonstration of acute cor pulmonale at the bedside in the medical intensive care unit. (12421740)
2002
10
Elevated plasma brain natriuretic peptide levels in chronic respiratory failure with cor pulmonale. (10464838)
1999
11
Relationship between plasma endothelin, nitric oxide, calcitonin gene-related peptide levels and pulmonary hemodynamics in patients with chronic cor pulmonale]. (11326879)
1998
12
Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale. (9059545)
1997
13
Cor pulmonale and silicosis: a necropsy based case-control study. (8329320)
1993
14
Alcohol and cor pulmonale in chronic bronchitis and emphysema. (8461684)
1993
15
Cor pulmonale subacute and recurrent erythema nodosum leprosum. (8464323)
1993
16
Congenital acquired immunodeficiency syndrome presenting as cor pulmonale in a 10-year-old girl. (2000766)
1991
17
Etiology of cor pulmonale. (2391736)
1990
18
Evaluation of the safety and efficacy of amrinone in chronic obstructive lung disease with cor pulmonale. (2316304)
1990
19
Cor pulmonale in an Angus cow. (2590140)
1989
20
The effect of six months of daily treatment with the beta-2 agonist oral pirbuterol on pulmonary hemodynamics in patients with chronic hypoxic cor pulmonale receiving long-term oxygen therapy. (2563321)
1989
21
Cor pulmonale due to tumor cell microemboli. Report of a case with occult gastric carcinoma. (2845876)
1988
22
Long term follow-up of domiciliary oxygen therapy in hypoxic cor pulmonale associated with chronic obstructive airways disease. (3690041)
1987
23
Noninvasive method to assess cor pulmonale in patients with chronic obstructive pulmonary disease. (2954775)
1987
24
Spontaneous rupture of the bladder in a patient with cor pulmonale presenting as acute abdominal emergency. (3748942)
1986
25
Hemodynamic effect of hydralazine in interstitial lung disease patients with cor pulmonale. Immediate and short-term evaluation at rest and during exercise. (3987368)
1985
26
Unilateral calcified fibrothorax with cor pulmonale: failure to improve with decortication. (6867770)
1983
27
Subacute cor pulmonale in hypersensitivity pneumonitis. A case report. (7135142)
1982
28
Scoliosis and cor pulmonale. (7135067)
1982
29
Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. (6110912)
1981
30
Left ventricular volumetry and function in chronic cor pulmonale. (7249663)
1981
31
Acute cor pulmonale resulting from tumor microembolism. (7376655)
1980
32
Management of patients with cor pulmonale. (431194)
1979
33
Pulmonary tuberculosis and cor pulmonale. (731047)
1978
34
Electrocardiographic reversion of acute cor pulmonale on long-term oxygen therapy. (609990)
1977
35
Sex differences in chronic cor pulmonale in delhi. (990163)
1976
36
Editorial: Oedema in cor pulmonale. (54804)
1975
37
Nursing care study: chronic bronchitis, emphysema and cor pulmonale. (1196907)
1975
38
Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. (1173819)
1975
39
Anti-heart antibodies in patients with chronic cor pulmonale. (1121059)
1975
40
Acute respiratory insufficiency and cor pulmonale. Pathophysiology, clinical features, and management. II. Management. (4152189)
1974
41
Present status of treatment of chronic cor pulmonale with congestive failure. (4147007)
1973
42
Left ventricular function, metabolism, and blood flow in chronic cor pulmonale. (4572384)
1973
43
The pathophysiology of the pulmonary circulation in cor pulmonale. (5084597)
1972
44
Respiratory function and right heart haemodynamics in chronic cor pulmonale. (5122798)
1971
45
A dynamic electrocardiographic concept useful in the diagnosis of cor pulmonale. Result of a survey of 200 patients with chronic obstructive pulmonary disease. (4249377)
1970
46
A clinical study of chronic cor pulmonale in Northern India. (5370718)
1969
47
ACUTE COR PULMONALE AND SHOCK. (14348043)
1965
48
The mechanisms of chronic pulmonary heart disease (cor pulmonale), with and without arterial hypoxemia. (13623896)
1959
49
L'noradrenaline in treatment of acute cor pulmonale. (13269845)
1955
50
Pulmonary embolism with acute cor pulmonale and extremely rapid ventricular rate in a young, active apparently healthy adult. (15395458)
1949

Variations for Cor Pulmonale

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Expression for genes affiliated with Cor Pulmonale

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cor Pulmonale

Search GEO for disease gene expression data for Cor Pulmonale.

Pathways for genes affiliated with Cor Pulmonale

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51PathCards, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database
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Pathways related to Cor Pulmonale according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2NPPB, NPPA
29.2NPPB, NPPA
39.1NPPA, EDN1
48.7NPPB, NPPA, EDN1

Compounds for genes affiliated with Cor Pulmonale

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46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Cor Pulmonale according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1tezosentan469.8NPPB, EDN1
2darusentan46 3010.8NPPB, EDN1
3bosentan46 1210.6EDN1, NPPB
4p00035469.6NPPB, NPPA
5hncs469.6NPPB, NPPA
6alacepril469.5NPPA, NPPB
7candoxatril46 1210.5NPPB, NPPA
8imidapril46 5210.5NPPA, NPPB
9toki-shakuyaku-san469.5NPPA, EDN1
10bisoprolol46 52 1211.4NPPB, NPPA
11dobutamine46 30 52 1212.4NPPA, NPPB
12bq12346 3010.4EDN1, NPPA
13cilazapril46 1210.3EDN1, NPPA
14ly 83583469.3NPPA, NPPC
15isosorbide dinitrate46 52 1211.3EDN1, NPPA
16fosinopril46 1210.3NPPA, NPPB
17moxonidine469.2NPPB, NPPA
18carbachol46 30 1211.1NPPC, NPPB, EDN1
19trandolapril46 1210.1EDN1, NPPB, NPPA
20enalaprilat469.1EDN1, NPPA, NPPB
21enalapril46 52 1211.1EDN1, NPPB, NPPA
22carvedilol46 52 30 1212.1EDN1, NPPA, NPPB
23phosphoramidon46 1210.1EDN1, NPPA, NPPB
24sildenafil30 46 52 25 1213.1EDN1, NPPA, NPPB
25nitroglycerin46 1210.1NPPA, NPPB, EDN1
26furosemide46 62 30 52 25 1214.1SLC4A1, NPPA, NPPB
27ang ii469.0EDN1, NPPB, NPPA
28captopril46 62 52 30 1213.0EDN1, NPPA, NPPB
29zaprinast46 3010.0NPPA, NPPC
30losartan46 52 30 1212.0EDN1, NPPA, NPPB
318-bromo cgmp469.0NPPB, NPPC, NPPA
32omapatrilat469.0NPPC, EDN1, NPPA
33thiorphan46 30 1210.9NPPA, NPPC, EDN1
34iberiotoxin46 62 3010.9NPPC, NPPA
35ng-nitro-l-arginine468.9EDN1, NPPC, NPPA
36guanylate468.9NPPA, NPPB, NPPC
37urodilatin468.5NPPC, EDN1, NPPA, NPPB
38hanp468.5NPPA, NPPB, EDN1, NPPC
39s-nitroso-n-acetylpenicillamine468.5NPPC, EDN1, NPPA, NPPB
40l-nmma468.5EDN1, NPPB, NPPC, NPPA
41phenylephrine46 30 25 1211.5NPPC, NPPA, NPPB, EDN1
42sodium nitroprusside468.5EDN1, NPPC, NPPB, NPPA
43cgmp46 309.5EDN1, NPPC, NPPB, NPPA
44isoproterenol46 129.5NPPB, EDN1, NPPA, NPPC
45prostacyclin468.5NPPC, NPPB, NPPA, EDN1
46norepinephrine46 25 1210.4NPPA, EDN1, NPPC, NPPB
47creatinine468.4NPPA, EDN1, NPPC, NPPB
48chloride468.2SLC4A1, NPPC, NPPA
49sodium46 259.0EDN1, NPPA, NPPB, NPPC, SLC4A1
50nitric oxide46 25 129.9EDN1, SLC4A1, NPPA, NPPB, NPPC

GO Terms for genes affiliated with Cor Pulmonale

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17Gene Ontology
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Cellular components related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1NPPC, NPPB, NPPA, EDN1

Biological processes related to Cor Pulmonale according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1body fluid secretionGO:0075899.6EDN1, NPPB
2positive regulation of urine volumeGO:0358109.6NPPB, EDN1
3positive regulation of renal sodium excretionGO:0358159.5NPPB, EDN1
4cell surface receptor signaling pathwayGO:0071669.5NPPB, EDN1
5regulation of blood pressureGO:0082179.1NPPA, NPPB
6negative regulation of cell growthGO:0303088.9NPPB, NPPA
7cGMP biosynthetic processGO:0061828.8NPPC, NPPB, NPPA
8receptor guanylyl cyclase signaling pathwayGO:0071688.8NPPC, NPPB, NPPA
9regulation of blood vessel sizeGO:0508808.8NPPA, NPPB, NPPC
10response to hypoxiaGO:0016668.7NPPC, NPPA, EDN1

Molecular functions related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:0514288.7NPPC, NPPA
2receptor bindingGO:0051028.6NPPC, NPPB, NPPA
3hormone activityGO:0051798.0NPPC, NPPB, NPPA, EDN1

Products for genes affiliated with Cor Pulmonale

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  • Antibodies
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Sources for Cor Pulmonale

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet