MCID: CRP018
MIFTS: 40

Cor Pulmonale malady

Summaries for Cor Pulmonale

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Cor pulmonale (Latin cor, heart + New Latin pulmōnāle, of the lungs), also known as pulmonary heart... more...

MalaCards: Cor Pulmonale, also known as chronic pulmonary heart disease, is related to cystic fibrosis and acute cor pulmonale. An important gene associated with Cor Pulmonale is NPPB (natriuretic peptide B), and among its related pathways are melatonin degradation II and Methionine salvage pathway. The compounds norepinephrine and isoproterenol have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are muscle and hematopoietic system.

Aliases & Classifications for Cor Pulmonale

Sources:
10DISEASES, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

cor pulmonale 10 45
chronic pulmonary heart disease 61


Related Diseases for Cor Pulmonale

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cor Pulmonale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis31.0NPPC
2acute cor pulmonale30.7PDZK1IP1
3asthma30.7NPPC, EDN1, GPX3
4sickle cell disease30.4EDN1
5vascular disease30.4SOD1, NPPC, EDN1, AGER, AGTR1, SERPINC1
6anuria30.2MB
7hypertensive heart disease30.2AGTR1, NPPA, NPPB
8primary pulmonary hypertension30.2NPPB, NPPA, EDN1
9arthritis30.2AGTR1, AGER, MB
10coronary artery disease,30.2MB, NPPB, NPPC, NPPA, EDN1, AGER
11atherosclerosis30.2SOD1, MB, NPPC, EDN1, AGER, AGTR1
12pulmonary disease, chronic obstructive10.9
13bronchitis10.6
14pulmonary tuberculosis10.6
15tuberculosis10.6
16pulmonary function10.5
17pulmonary alveolar microlithiasis10.4
18cardiac tamponade10.3
19ankylosing spondylitis10.3
20patent foramen ovale10.3
21pulmonary edema10.3
22hemosiderosis10.3
23homocystinuria10.3
24acquired immunodeficiency syndrome10.3
25silicosis10.3
26pycnodysostosis10.3
27spondylitis10.3
28aminoaciduria10.3
29sleep apnea10.3
30marfan syndrome10.2
31hemoglobin d disease10.2
32niemann-pick disease10.2
33acute interstitial pneumonia10.2
34acute chest syndrome10.2
35ankylosis10.2
36idiopathic pulmonary fibrosis10.2
37hyperlucent lung10.2
38interstitial emphysema10.2
39pulmonary sarcoidosis10.2
40systemic lupus erythematosus10.2
41arteriolosclerosis10.2
42bronchiectasis10.2
43endocardial fibroelastosis10.2
44cleft palate10.2
45pick's disease10.2
46asbestosis10.2
47rheumatoid lung disease10.2
48tonsillitis10.2
49anorexia nervosa10.2
50posterior myocardial infarction10.2

Graphical network of the top 20 diseases related to Cor Pulmonale:



Diseases related to cor pulmonale

Clinical Features for Cor Pulmonale

Drugs & Therapeutics for Cor Pulmonale

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cor Pulmonale

Drug clinical trials:

Search ClinicalTrials for Cor Pulmonale

Search NIH Clinical Center for Cor Pulmonale

Search CenterWatch for Cor Pulmonale

Genetic Tests for Cor Pulmonale

Anatomical Context for Cor Pulmonale

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cor Pulmonale:

33
Heart, Lung

Animal Models for Cor Pulmonale or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cor Pulmonale

Sources:
51PubMed
See all sources

Articles related to Cor Pulmonale:

(show all 15)
idTitleAuthorsYear
1
The successful use of phosphodiesterase type 5 inhibitors to treat the syndrome of cor pulmonale and prerenal azotemia with diuresis of anasarca (CorPRADA). (20065909)
2010
2
Permanently increased brightness of right ventricle (D-shaped left ventricle) on myocardial perfusion imaging in a patient with chronic cor pulmonale: an autopsy correlation. (16580965)
2006
3
Production of endogenous nitric oxide in chronic obstructive pulmonary disease and patients with cor pulmonale. Correlates with echo-Doppler assessment. (10934068)
2000
4
Red cell magnesium concentration in cor pulmonale. Correlation with cardiopulmonary findings. (8449063)
1993
5
Clinicopathological correlations in cor pulmonale. (1412090)
1992
6
Cor pulmonale: correlation with central airway lesions, peripheral airway lesions, emphysema, and control of breathing. (2339840)
1990
7
Adenotonsillar hypertrophy and cor pulmonale: clinical and echocardiographic correlation. (2602239)
1989
8
Pathological and prognostic correlations of exercise studies in hypoxic cor pulmonale. (3465564)
1986
9
Cardiac pathology in schistosomal cor pulmonale correlated with chest roentgenographs; a case report. (2938322)
1986
10
Clinical and electrocardiographic correlations in pulmonary heart disease (cor pulmonale). (589625)
1977
11
Effect of isosorbide dinitrate on hemodynamics and respiration of patients with coronary artery disease and of patients with chronic cor pulmonale. (1166140)
1975
12
Left ventricular performance and condition of coronary arteries in chronic cor pulmonale. (4752832)
1973
13
Myocardial function in chronic pulmonary diseases. The role of the coronary arteries in chronic cor pulmonale. (4267071)
1972
14
The coronary arteries in chronic cor pulmonale. (5316280)
1971
15
Cor Pulmonale. Including a short note on pulmo cordis (cardiac lung disease). (4914931)
1970

Genetic Variations for Cor Pulmonale

Expression for genes affiliated with Cor Pulmonale

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cor Pulmonale

Search GEO for disease gene expression data for Cor Pulmonale.

Pathways for genes affiliated with Cor Pulmonale

Sources:
38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Cor Pulmonale according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8SMOX, PAOX
2
Hide members
9.8SMOX, PAOX
39.8SEPN1, GPX3, SOD1

Compounds for genes affiliated with Cor Pulmonale

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Cor Pulmonale according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.5MB, NPPC
2isoproterenol45 1111.5AGTR1, NPPC
3captopril45 29 50 60 1114.5REN, EDN1
4toki-shakuyaku-san4510.3REN, EDN1, NPPA
5alacepril4510.2REN, NPPB, NPPA
6omapatrilat4510.2REN, EDN1, NPPA, NPPC
7cilazapril45 1111.2AGTR1, NPPA, REN, EDN1
8trimetazidine4510.2SOD1, EDN1, MB
9darusentan45 2911.1REN, EDN1, NPPB
10enalaprilat4510.1EDN1, NPPA, NPPB, REN
11fosinopril45 1111.1AGTR1, NPPA, NPPB, REN
12ng-nitro-l-arginine4510.1NPPC, NPPA, EDN1, SOD1
13quinapril45 1111.1REN, EDN1, NPPA, AGTR1
14lisinopril45 11 2412.1REN, NPPB, AGTR1, NPPA
15valsartan45 60 29 1113.1AGTR1, REN, NPPB, EDN1
16ramipril45 1111.1REN, NPPA, AGTR1, NPPB
17s-nitroso-n-acetylpenicillamine4510.1NPPA, NPPB, EDN1, SOD1, NPPC
18perindopril45 50 1112.1REN, AGTR1, NPPA, NPPB
19urodilatin4510.1REN, NPPB, NPPC, NPPA, EDN1
20hanp4510.1NPPB, NPPA, NPPC, EDN1, REN
21telmisartan45 29 1112.0AGTR1, AGER, NPPB, REN
22trandolapril45 1111.0AGTR1, NPPA, NPPB, EDN1, REN
23phenylephrine45 29 11 2413.0EDN1, NPPB, NPPC, NPPA, AGTR1
24enalapril45 50 1112.0REN, AGTR1, EDN1, NPPA, NPPB
25carvedilol45 50 29 1113.0AGTR1, REN, NPPA, NPPB, EDN1
26oxygen45 2411.0MB, PAOX, SMOX
27ang ii4510.0EDN1, AGTR1, NPPA, REN, NPPB
28furosemide45 50 60 29 11 2415.0AGTR1, NPPA, SLC4A1, REN, NPPB
29candesartan45 29 1112.0REN, NPPB, AGTR1, AGER
30lacidipine4510.0REN, AGTR1, EDN1
31l-nmma459.9SOD1, NPPC, AGTR1, EDN1, NPPB, NPPA
328-isoprostane459.9NPPB, GPX3, EDN1, AGTR1, SOD1
33amlodipine45 50 11 2412.9NPPA, REN, AGTR1, NPPB
34diltiazem45 29 1111.9SERPINC1, REN, AGTR1, EDN1
35losartan45 50 29 1112.9REN, NPPB, EDN1, NPPA, AGTR1
36spironolactone50 45 60 29 1113.9NPPB, AGTR1, REN, NPPA
37heparin45 29 11 2412.9GPX3, MB, A2M, AGER
38nitroglycerin45 1110.9NPPA, NPPB, REN, AGTR1, EDN1, SOD1
39cgmp45 2910.8NPPC, NPPA, REN, NPPB, EDN1, AGTR1
40uric acid45 2410.7NPPB, GPX3, AGER, AGTR1, SOD1
41haloperidol45 29 2 50 1113.7REN, AGTR1, NPPA, NPPB, MB
42sodium nitroprusside459.5EDN1, REN, SOD1, AGTR1, NPPA, NPPC
43dopamine45 29 11 2412.4MB, REN, AGTR1, AGER, NPPB, PHOX2B
44epinephrine45 11 2411.4MB, REN, NPPB, NPPA, EDN1, AGTR1
45prostacyclin459.3AGER, REN, AGTR1, EDN1, NPPA, NPPC
46sodium45 2410.2SLC4A1, REN, AGTR1, NPPC, NPPB, EDN1
47nitric oxide45 11 2411.0NPPA, SOD1, NPPC, SLC4A1, AGER, AGTR1
48arginine458.9REN, AGTR1, EDN1, NPPB, MB, SOD1
49creatinine458.7REN, SOD1, MB, NPPB, NPPC, NPPA
50vegf458.6AGTR1, SERPINC1, REN, AGER, EDN1, NPPA

GO Terms for genes affiliated with Cor Pulmonale

Sources:
16Gene Ontology
See all sources

Cellular components related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6NPPB, NPPC, NPPA, A2M, EDN1, AGER
2extracellular spaceGO:0056158.3SERPINC1, SOD1, NPPB, NPPC, NPPA, A2M

Biological processes related to Cor Pulmonale according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1body fluid secretionGO:00758910.3EDN1, NPPB
2cGMP biosynthetic processGO:00618210.3NPPA, NPPC, NPPB
3receptor guanylyl cyclase signaling pathwayGO:00716810.3NPPB, NPPC, NPPA
4regulation of blood vessel sizeGO:05088010.3NPPA, NPPC, NPPB
5regulation of vasodilationGO:04231210.3AGTR1, NPPB
6regulation of vasoconstrictionGO:01922910.3AGTR1, EDN1, NPPC
7renin-angiotensin regulation of aldosterone productionGO:00201810.3REN, AGTR1
8positive regulation of urine volumeGO:03581010.2NPPB, EDN1
9positive regulation of renal sodium excretionGO:03581510.2EDN1, NPPB
10spermine catabolic processGO:04620810.1PAOX, SMOX
11polyamine catabolic processGO:00659810.1PAOX, SMOX
12superoxide anion generationGO:04255410.0EDN1, SOD1
13polyamine biosynthetic processGO:00659610.0PAOX, SMOX
14regulation of blood pressureGO:0082179.9REN, NPPA, NPPC, NPPB, SOD1
15elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.9AGTR1, EDN1
16polyamine metabolic processGO:0065959.8SMOX, PAOX

Molecular functions related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.2NPPA, NPPC
2hormone activityGO:0051799.9EDN1, NPPA, NPPC, NPPB
3polyamine oxidase activityGO:0465929.7SMOX, PAOX
4spermine:oxygen oxidoreductase (spermidine-forming) activityGO:0529019.5SMOX, PAOX
5receptor bindingGO:0051029.5NPPB, NPPC, NPPA, REN, PAOX

Products for genes affiliated with Cor Pulmonale

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cor Pulmonale

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet