MCID: CRP018
MIFTS: 36

Cor Pulmonale malady

Summaries for Cor Pulmonale

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cor pulmonale (Latin cor, heart + New Latin pulmōnāle, of the lungs), also known as pulmonary heart... more...

MalaCards: Cor Pulmonale, also known as chronic pulmonary heart disease, is related to acute cor pulmonale and hypertension. An important gene associated with Cor Pulmonale is NPPB (natriuretic peptide B), and among its related pathways are melatonin degradation II and Methionine salvage pathway. The compounds norepinephrine and isoproterenol have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are muscle and hematopoietic system.

Aliases & Classifications for Cor Pulmonale

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60UMLS, 10DISEASES, 44Novoseek
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Aliases & Descriptions:

cor pulmonale 10 44
chronic pulmonary heart disease 60


Related Diseases for Cor Pulmonale

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17GeneCards, 18GeneDecks
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Diseases related to Cor Pulmonale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1acute cor pulmonale31.6PDZK1IP1
2hypertension31.2REN, AGTR1, EDN1, NPPA, NPPC, NPPB
3pulmonary embolism31.2NPPB, SERPINC1
4cystic fibrosis30.9NPPC
5respiratory failure30.9SLC4A1, SERPINC1
6pneumonia30.6MB
7pulmonary fibrosis30.6AGTR1, EDN1, SOD1
8asthma30.6NPPC, EDN1, GPX3
9myocardial infarction30.6MB, NPPB, NPPC, NPPA, EDN1, AGER
10congestive heart failure30.5REN, NPPC
11sickle cell disease30.4EDN1
12vascular disease30.4SOD1, NPPC, EDN1, AGER, AGTR1, SERPINC1
13coronary artery disease30.4MB, NPPB, NPPC, NPPA, EDN1, AGER
14glomerulonephritis30.2AGTR1
15obesity30.2AGER
16anuria30.2MB
17hypertensive heart disease30.2AGTR1, NPPA, NPPB
18primary pulmonary hypertension30.2NPPB, NPPA, EDN1
19arthritis30.2AGTR1, AGER, MB
20breast cancer30.2SMOX, GPX3
21myopathy30.2SEPN1, MB
22atherosclerosis30.1SOD1, MB, NPPC, EDN1, AGER, AGTR1
23bronchitis10.6
24obstructive lung disease10.6
25pulmonary tuberculosis10.5
26tuberculosis10.5
27adenoiditis10.5
28nasopharyngitis10.4
29pulmonary alveolar microlithiasis10.4
30tonsillitis10.4
31chronic pulmonary heart disease10.4
32interstitial lung disease10.4
33pericardial effusion10.4
34pulmonary emphysema10.4
35sarcoidosis10.4
36cardiac tamponade10.3
37ankylosing spondylitis10.3
38patent foramen ovale10.3
39pulmonary edema10.3
40hemosiderosis10.3
41homocystinuria10.3
42acquired immunodeficiency syndrome10.3
43silicosis10.3
44pycnodysostosis10.3
45mediastinitis10.3
46neuromuscular disease10.3
47polycythemia10.3
48spondylitis10.3
49burns10.1
50niemann-pick disease10.1

Graphical network of the top 20 diseases related to Cor Pulmonale:



Diseases related to cor pulmonale

Clinical Features for Cor Pulmonale

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Drugs & Therapeutics for Cor Pulmonale

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cor Pulmonale

Drug clinical trials:

Search ClinicalTrials for Cor Pulmonale

Search NIH Clinical Center for Cor Pulmonale

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Genetic Tests for Cor Pulmonale

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Anatomical Context for Cor Pulmonale

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32MalaCards
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MalaCards organs/tissues related to Cor Pulmonale:

32
Heart, Lung

Animal Models for Cor Pulmonale or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cor Pulmonale:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7SOD1, MB, NPPB, NPPA, EDN1, AGER
2MP:00053978.5MB, NPPA, AGER, REN, RNF128, GPX3
3MP:00053678.5NPPA, EDN1, AGER, AGTR1, REN, GPX3
4MP:00053858.1SERPINC1, SOD1, MB, NPPB, NPPA, PHOX2B
5MP:00053767.9PHOX2B, NPPA, NPPC, MB, SOD1, EDN1

Publications for Cor Pulmonale

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Genetic Variations for Cor Pulmonale

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Expression for genes affiliated with Cor Pulmonale

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cor Pulmonale

Search GEO for disease gene expression data for Cor Pulmonale.

Pathways for genes affiliated with Cor Pulmonale

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Cor Pulmonale according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8SMOX, PAOX
2
Hide members
9.8SMOX, PAOX
39.8SEPN1, GPX3, SOD1

Compounds for genes affiliated with Cor Pulmonale

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Cor Pulmonale according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.5MB, NPPC
2isoproterenol44 1111.5AGTR1, NPPC
3captopril44 28 49 59 1114.5REN, EDN1
4toki-shakuyaku-san4410.3REN, EDN1, NPPA
5alacepril4410.2REN, NPPB, NPPA
6omapatrilat4410.2REN, EDN1, NPPA, NPPC
7cilazapril44 1111.2AGTR1, NPPA, REN, EDN1
8trimetazidine4410.2SOD1, EDN1, MB
9darusentan44 2811.1REN, EDN1, NPPB
10enalaprilat4410.1EDN1, NPPA, NPPB, REN
11fosinopril44 1111.1AGTR1, NPPA, NPPB, REN
12ng-nitro-l-arginine4410.1NPPC, NPPA, EDN1, SOD1
13quinapril44 1111.1REN, EDN1, NPPA, AGTR1
14lisinopril44 11 2412.1REN, NPPB, AGTR1, NPPA
15valsartan44 59 28 1113.1AGTR1, REN, NPPB, EDN1
16ramipril44 1111.1REN, NPPA, AGTR1, NPPB
17s-nitroso-n-acetylpenicillamine4410.1NPPA, NPPB, EDN1, SOD1, NPPC
18perindopril44 49 1112.1REN, AGTR1, NPPA, NPPB
19urodilatin4410.1REN, NPPB, NPPC, NPPA, EDN1
20hanp4410.1NPPB, NPPA, NPPC, EDN1, REN
21telmisartan44 28 1112.0AGTR1, AGER, NPPB, REN
22trandolapril44 1111.0AGTR1, NPPA, NPPB, EDN1, REN
23phenylephrine44 28 11 2413.0EDN1, NPPB, NPPC, NPPA, AGTR1
24enalapril44 49 1112.0REN, AGTR1, EDN1, NPPA, NPPB
25carvedilol44 49 28 1113.0AGTR1, REN, NPPA, NPPB, EDN1
26oxygen44 2411.0MB, PAOX, SMOX
27ang ii4410.0EDN1, AGTR1, NPPA, REN, NPPB
28furosemide44 49 59 28 11 2415.0AGTR1, NPPA, SLC4A1, REN, NPPB
29candesartan44 28 1112.0REN, NPPB, AGTR1, AGER
30lacidipine4410.0REN, AGTR1, EDN1
31l-nmma449.9SOD1, NPPC, AGTR1, EDN1, NPPB, NPPA
328-isoprostane449.9NPPB, GPX3, EDN1, AGTR1, SOD1
33amlodipine44 49 11 2412.9NPPA, REN, AGTR1, NPPB
34diltiazem44 28 1111.9SERPINC1, REN, AGTR1, EDN1
35losartan44 49 28 1112.9REN, NPPB, EDN1, NPPA, AGTR1
36spironolactone49 44 59 28 1113.9NPPB, AGTR1, REN, NPPA
37heparin44 28 11 2412.9GPX3, MB, A2M, AGER
38nitroglycerin44 1110.9NPPA, NPPB, REN, AGTR1, EDN1, SOD1
39cgmp44 2810.8NPPC, NPPA, REN, NPPB, EDN1, AGTR1
40uric acid44 2410.7NPPB, GPX3, AGER, AGTR1, SOD1
41haloperidol44 28 2 49 1113.7REN, AGTR1, NPPA, NPPB, MB
42sodium nitroprusside449.5EDN1, REN, SOD1, AGTR1, NPPA, NPPC
43dopamine44 28 11 2412.4MB, REN, AGTR1, AGER, NPPB, PHOX2B
44epinephrine44 11 2411.4MB, REN, NPPB, NPPA, EDN1, AGTR1
45prostacyclin449.3AGER, REN, AGTR1, EDN1, NPPA, NPPC
46sodium44 2410.2SLC4A1, REN, AGTR1, NPPC, NPPB, EDN1
47nitric oxide44 11 2411.0NPPA, SOD1, NPPC, SLC4A1, AGER, AGTR1
48arginine448.9REN, AGTR1, EDN1, NPPB, MB, SOD1
49creatinine448.7REN, SOD1, MB, NPPB, NPPC, NPPA
50vegf448.6AGTR1, SERPINC1, REN, AGER, EDN1, NPPA

GO Terms for genes affiliated with Cor Pulmonale

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16Gene Ontology
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Cellular components related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6NPPB, NPPC, NPPA, A2M, EDN1, AGER
2extracellular spaceGO:0056158.3SERPINC1, SOD1, NPPB, NPPC, NPPA, A2M

Biological processes related to Cor Pulmonale according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1body fluid secretionGO:00758910.3EDN1, NPPB
2cGMP biosynthetic processGO:00618210.3NPPA, NPPC, NPPB
3receptor guanylyl cyclase signaling pathwayGO:00716810.3NPPB, NPPC, NPPA
4regulation of blood vessel sizeGO:05088010.3NPPA, NPPC, NPPB
5regulation of vasodilationGO:04231210.3AGTR1, NPPB
6regulation of vasoconstrictionGO:01922910.3AGTR1, EDN1, NPPC
7renin-angiotensin regulation of aldosterone productionGO:00201810.3REN, AGTR1
8positive regulation of urine volumeGO:03581010.2NPPB, EDN1
9positive regulation of renal sodium excretionGO:03581510.2EDN1, NPPB
10spermine catabolic processGO:04620810.1PAOX, SMOX
11polyamine catabolic processGO:00659810.1PAOX, SMOX
12superoxide anion generationGO:04255410.0EDN1, SOD1
13polyamine biosynthetic processGO:00659610.0PAOX, SMOX
14regulation of blood pressureGO:0082179.9REN, NPPA, NPPC, NPPB, SOD1
15elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.9AGTR1, EDN1
16polyamine metabolic processGO:0065959.8SMOX, PAOX

Molecular functions related to Cor Pulmonale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:05142810.2NPPA, NPPC
2hormone activityGO:0051799.9EDN1, NPPA, NPPC, NPPB
3polyamine oxidase activityGO:0465929.7SMOX, PAOX
4spermine:oxygen oxidoreductase (spermidine-forming) activityGO:0529019.5SMOX, PAOX
5receptor bindingGO:0051029.5NPPB, NPPC, NPPA, REN, PAOX

Products for genes affiliated with Cor Pulmonale

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  • Antibodies
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Sources for Cor Pulmonale

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet