MCID: CRB138
MIFTS: 40

Core Binding Factor Acute Myeloid Leukemia malady

Summaries for Core Binding Factor Acute Myeloid Leukemia

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22Genetics Home Reference, 34MalaCards
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Genetics Home Reference:22 Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.

MalaCards: Core Binding Factor Acute Myeloid Leukemia, also known as cbf acute myeloid leukemia, is related to acute myeloid leukemia and myeloid leukemia. An important gene associated with Core Binding Factor Acute Myeloid Leukemia is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Hematopoietic cell lineage and Development FGFR signaling pathway. The compounds tandutinib and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include myeloid and eye, and related mouse phenotypes are craniofacial and liver/biliary system.

Aliases & Classifications for Core Binding Factor Acute Myeloid Leukemia

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22Genetics Home Reference
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Aliases & Descriptions:

core binding factor acute myeloid leukemia 22
cbf acute myeloid leukemia 22
core-binding factor aml 22
cbf-aml 22


Related Diseases for Core Binding Factor Acute Myeloid Leukemia

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18GeneCards, 19GeneDecks
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Diseases related to Core Binding Factor Acute Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1acute myeloid leukemia31.9KIT, FLT3, RUNX1
2myeloid leukemia31.6HRAS, KIT, CBFB, JAK2, FLT3, RUNX1
3leukemia31.5RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT
4systemic mastocytosis30.7KIT, JAK2
5mastocytosis10.4
6hematopoietic stem cell transplantation10.4
7myeloid sarcoma10.1KIT, FLT3
8mast cell neoplasm10.1FLT3, KIT
9leukemia, acute lymphoblastic 310.1KIT, FLT3
10myelofibrosis10.1JAK2
11gastrointestinal stromal tumor10.1KIT, FLT3
12neurofibromatosis10.0HRAS, KIT
13acute myelomonocytic leukemia10.0RUNX1, CBFB
14acute lymphoblastic leukemia, childhood10.0RUNX1, FLT3
15chronic myeloproliferative disease10.0FLT3, JAK2
16hemorrhagic thrombocythemia10.0KIT, JAK2
17acute promyelocytic leukemia10.0FLT3, RUNX1
18acute myeloid leukemia, adult10.0KIT, FLT3, RUNX1
19thyroid cancer10.0HRAS, FLT3
20thrombocytosis10.0JAK2, FLT3
21kidney cancer10.0FLT3, KIT, HRAS
22juvenile myelomonocytic leukemia10.0RUNX1, FLT3, HRAS
23eosinophilia10.0JAK2, CBFB
24cleidocranial dysplasia10.0CBFB, RUNX2, RUNX1
25polycythemia vera10.0KIT, JAK2, FLT3
26hypersensitivity reaction type ii disease10.0RUNX1, FLT3, HRAS
27retinoblastoma10.0RUNX1, RUNX2, HRAS
28down syndrome10.0JAK2, FLT3, RUNX1
29prostate cancer10.0HRAS, JAK2, FLT3
30stomach cancer10.0CBFB, RUNX2, RUNX1
31glioblastoma multiforme10.0HRAS, KIT, JAK2
32refractory anemia9.9KIT, JAK2, FLT3, RUNX1
33chronic myelomonocytic leukemia9.9RUNX1, FLT3, JAK2, KIT
34melanoma9.9HRAS, KIT, JAK2, FLT3
35sarcoma9.9RUNX1, JAK2, KIT, HRAS
36ovarian cancer9.9HRAS, JAK2, RUNX1
37precursor t-cell acute lymphoblastic leukemia9.9RUNX1, FLT3, JAK2, HRAS
38rheumatoid arthritis9.9RUNX1, RUNX2, JAK2
39myelodysplastic syndromes9.9RUNX1, FLT3, JAK2, CBFB, KIT
40colon cancer9.9HRAS, JAK2, RUNX1
41myeloproliferative disorder9.9RUNX1, FLT3, JAK2, KIT, HRAS
42hematologic cancer9.9HRAS, KIT, JAK2, FLT3, RUNX1
43burkitt's lymphoma9.8RUNX1, RUNX2, FLT3, JAK2, HRAS
44chronic myeloid leukemia9.8RUNX1, FLT3, JAK2, CBFB, KIT, HRAS
45acute leukemia9.8RUNX1, FLT3, JAK2, CBFB, KIT, HRAS
46acute lymphocytic leukemia9.8RUNX1, FLT3, JAK2, CBFB, KIT, HRAS
47breast cancer9.8RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT

Graphical network of the top 20 diseases related to Core Binding Factor Acute Myeloid Leukemia:



Diseases related to core binding factor acute myeloid leukemia

Symptoms for Core Binding Factor Acute Myeloid Leukemia

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Drugs & Therapeutics for Core Binding Factor Acute Myeloid Leukemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Core Binding Factor Acute Myeloid Leukemia

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Anatomical Context for Core Binding Factor Acute Myeloid Leukemia

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34MalaCards
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MalaCards organs/tissues related to Core Binding Factor Acute Myeloid Leukemia:

34
Myeloid, Eye

Animal Models for Core Binding Factor Acute Myeloid Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Core Binding Factor Acute Myeloid Leukemia:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.6RUNX2, CBFB, KIT, HRAS
2MP:00053708.6KIT, CBFB, RUNX2, RUNX1
3MP:00028738.2HRAS, KIT, JAK2, RUNX1
4MP:00030128.2RUNX1, RUNX2, CBFB, KIT, HRAS
5MP:00053888.2RUNX1, RUNX2, CBFB, KIT, HRAS
6MP:00053858.1RUNX1, RUNX2, CBFB, KIT, HRAS
7MP:00053798.0RUNX2, JAK2, KIT, HRAS
8MP:00053808.0RUNX1, JAK2, CBFB, KIT
9MP:00036318.0RUNX1, RUNX2, CBFB, KIT, HRAS
10MP:00020067.7HRAS, KIT, CBFB, JAK2, FLT3, RUNX1
11MP:00053977.5RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT
12MP:00053877.5RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT
13MP:00053907.5RUNX1, RUNX2, JAK2, CBFB, KIT, HRAS
14MP:00107717.4RUNX1, RUNX2, JAK2, CBFB, KIT, HRAS
15MP:00053847.4RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT
16MP:00053787.1RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT
17MP:00053767.0RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT
18MP:00107687.0RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT

Publications for Core Binding Factor Acute Myeloid Leukemia

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53PubMed
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Articles related to Core Binding Factor Acute Myeloid Leukemia:

(show all 37)
idTitleAuthorsYear
1
The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia. (23783394)
2013
2
KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 rearrangement. (23053179)
2013
3
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. (23321257)
2013
4
Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children. (23677335)
2013
5
Core-binding factor acute myeloid leukemia: can we improve on HiDAC consolidation? (24319183)
2013
6
Therapy of core binding factor acute myeloid leukemia: incremental improvements toward better long-term results. (23266036)
2013
7
Prognosis of patients with core binding factor acute myeloid leukemia after first relapse. (23716553)
2013
8
Core binding factor acute myeloid leukemia: the impact of age, leukocyte count, molecular findings, and minimal residual disease. (23646898)
2013
9
Core-binding factor acute myeloid leukemia in pediatric patients enrolled in the AIEOP AML 2002/01 trial: screening and prognostic impact of c-KIT mutations. (24226631)
2013
10
Systemic mastocytosis is uncommon in KIT D816V mutation positive core-binding factor acute myeloid leukemia. (22145956)
2012
11
High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations. (22234698)
2012
12
Impact of residual normal metaphases in core binding factor acute myeloid leukemia. (21928314)
2012
13
A genome-wide single-nucleotide polymorphism-array can improve the prognostic stratification of the core binding factor acute myeloid leukemia. (22886749)
2012
14
Treatment strategies in patients with core-binding factor acute myeloid leukemia. (21755276)
2011
15
Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia. (21715005)
2011
16
Core binding factor acute myeloid leukemia (CBF-AML) in MAcxico: a single institution experience. (21574542)
2011
17
Core-binding factor acute myeloid leukemia. (22032582)
2011
18
Peripheral blasts on day 21 of induction chemotherapy in a patient with core binding factor acute myeloid leukemia: more than meets the eye. (20709669)
2010
19
Core binding factor acute myeloid leukemia (CBF-AML): is high-dose Ara-C (HDAC) consolidation as effective as you think? (19468270)
2009
20
Rapid detection of KIT mutations in core-binding factor acute myeloid leukemia using high-resolution melting analysis. (19644024)
2009
21
Hematopoietic stem cell transplantation for core binding factor acute myeloid leukemia: t(8;21) and inv(16) represent different clinical outcomes. (19126873)
2009
22
Monitoring of minimal residual disease in patients with core binding factor acute myeloid leukemia and the impact of C-KIT, FLT3, and JAK2 mutations on clinical outcome. (19603346)
2009
23
Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia. (18981008)
2008
24
Core binding factor acute myeloid leukemia. (18692691)
2008
25
A >or=1 log rise in RQ-PCR transcript levels defines molecular relapse in core binding factor acute myeloid leukemia and predicts subsequent morphologic relapse. (18297529)
2008
26
Autologous stem cell transplantation with PCR-negative graft would be associated with a favorable outcome in core-binding factor acute myeloid leukemia. (18940681)
2008
27
Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia. (18841055)
2008
28
Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples. (17960171)
2008
29
Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia. (17485551)
2007
30
Core binding factor acute myeloid leukemia. (16728942)
2006
31
Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML). (16598313)
2006
32
Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia. (16015387)
2005
33
Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study. (16110030)
2005
34
Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid leukemia. (15068897)
2004
35
Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup. (15289486)
2004
36
Core binding factor acute myeloid leukemia. Cancer and Leukemia Group B (CALGB) Study 8461. (15124687)
2004
37
Butyrates, as a single drug, induce histone acetylation and granulocytic maturation: possible selectivity on core binding factor-acute myeloid leukemia blasts. (14695213)
2003

Variations for Core Binding Factor Acute Myeloid Leukemia

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Expression for genes affiliated with Core Binding Factor Acute Myeloid Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Core Binding Factor Acute Myeloid Leukemia

Search GEO for disease gene expression data for Core Binding Factor Acute Myeloid Leukemia.

Pathways for genes affiliated with Core Binding Factor Acute Myeloid Leukemia

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51PathCards, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 55R&D Systems, 54QIAGEN, 52PharmGKB, 62Tocris Bioscience, 56Reactome, 5Cell Signaling Technology
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Pathways related to Core Binding Factor Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KIT, FLT3
2
Show member pathways
Development Flt3 signaling61
9.5HRAS, FLT3
3
Show member pathways
9.4RUNX1, HRAS
49.4RUNX2, CBFB
59.3RUNX2, HRAS
69.3RUNX1, RUNX2
7
Show member pathways
9.2HRAS, FLT3, KIT
8
Show member pathways
9.2FLT3, HRAS, KIT
9
Show member pathways
9.2HRAS, FLT3, KIT
10
Show member pathways
9.2HRAS, KIT, FLT3
11
Show member pathways
9.1JAK2, HRAS
129.1JAK2, HRAS
139.1HRAS, JAK2
149.1HRAS, JAK2
15
Show member pathways
9.1JAK2, HRAS
16
Show member pathways
EPO Receptor Signaling39
EPO signaling pathway39
9.1JAK2, HRAS
179.1JAK2, HRAS
18
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.1HRAS, JAK2
199.1JAK2, HRAS
20
Show member pathways
Immune response IL 3 activation and signaling pathway61
9.1JAK2, HRAS
219.0RUNX2, JAK2
228.9RUNX1, RUNX2, FLT3
238.9KIT, JAK2, FLT3
24
Show member pathways
8.8JAK2, HRAS, KIT
25
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)39
8.8HRAS, JAK2, KIT
26
Show member pathways
8.8HRAS, JAK2, KIT
27
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
8.8JAK2, KIT, HRAS
288.8JAK2, HRAS, KIT
29
Show member pathways
8.8KIT, JAK2, HRAS
30
Show member pathways
8.7JAK2, HRAS, FLT3
318.6HRAS, RUNX1, FLT3, KIT
32
Show member pathways
Signal transduction PTEN pathway61
8.6FLT3, RUNX1, HRAS, KIT
338.5HRAS, JAK2, RUNX2
34
Show member pathways
8.3HRAS, FLT3, KIT, JAK2
35
Show member pathways
8.3FLT3, HRAS, KIT, JAK2
36
Show member pathways
8.3HRAS, FLT3, KIT, JAK2
37
Show member pathways
8.3JAK2, KIT, HRAS, FLT3
38
Show member pathways
8.3KIT, JAK2, FLT3, HRAS

Compounds for genes affiliated with Core Binding Factor Acute Myeloid Leukemia

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR
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Compounds related to Core Binding Factor Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1tandutinib4610.1KIT, FLT3
2pkc 4124610.0KIT, FLT3
3ag-12964610.0KIT, FLT3
4su54164610.0KIT, FLT3
5ponatinib52 1211.0KIT, FLT3
6sunitinib46 52 1212.0KIT, FLT3
717-(allylamino)-17-demethoxygeldanamycin469.8KIT, FLT3
8methylcellulose469.8KIT, FLT3
9sorafenib46 52 1211.7FLT3, KIT
10beta-tyrosine469.7JAK2, KIT
11lestaurtinib46 6210.6JAK2, FLT3
12hydroxyurea46 52 1211.3KIT, JAK2
13valine469.1JAK2, KIT, HRAS
14herbimycin a46 6210.1HRAS, JAK2, FLT3
15arsenite46 2510.1JAK2, FLT3, RUNX1
16phenylalanine469.1JAK2, KIT, HRAS
17doxorubicin46 52 1211.0RUNX1, FLT3, KIT, HRAS
1812-o-tetradecanoylphorbol 13-acetate468.9HRAS, JAK2, RUNX1
19gp 130468.8FLT3, JAK2, KIT, HRAS
20imatinib46 52 1210.8RUNX1, FLT3, JAK2, KIT
21phosphotyrosine468.8HRAS, KIT, JAK2, FLT3
22butyrate468.7RUNX1, RUNX2, JAK2
23rapamycin468.7HRAS, KIT, JAK2, FLT3
24phosphoinositide468.7FLT3, JAK2, KIT, HRAS
25aspartate468.7FLT3, JAK2, KIT, HRAS
26ly294002468.7RUNX2, JAK2, HRAS
27leucine468.7HRAS, KIT, JAK2
28pge2468.6HRAS, JAK2, RUNX2
29atp46 309.6FLT3, JAK2, KIT, HRAS
30pd 98,059468.5HRAS, KIT, JAK2, RUNX2
31steroid468.5RUNX2, JAK2, KIT, HRAS
32nitric oxide46 25 1210.4RUNX2, JAK2, KIT, HRAS
33estrogen468.4RUNX2, JAK2, KIT, HRAS
34cycloheximide468.4KIT, JAK2, RUNX2
35glucose468.3HRAS, KIT, JAK2, RUNX2
36threonine468.2RUNX1, FLT3, JAK2, KIT, HRAS
37thymidine46 259.2HRAS, KIT, JAK2, FLT3, RUNX2
38phosphatidylinositol468.1RUNX2, FLT3, JAK2, KIT, HRAS
39serine468.0RUNX1, RUNX2, JAK2, KIT, HRAS
40oligonucleotide467.6HRAS, KIT, JAK2, FLT3, RUNX2, RUNX1
41vegf467.6RUNX1, RUNX2, FLT3, JAK2, KIT, HRAS
42retinoic acid46 258.6RUNX1, RUNX2, FLT3, JAK2, KIT, HRAS
43tyrosine467.6RUNX1, RUNX2, FLT3, JAK2, KIT, HRAS

GO Terms for genes affiliated with Core Binding Factor Acute Myeloid Leukemia

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17Gene Ontology
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Biological processes related to Core Binding Factor Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.9KIT, FLT3
2embryonic hemopoiesisGO:0351629.8KIT, RUNX1
3definitive hemopoiesisGO:0602169.8CBFB, RUNX1
4myeloid cell differentiationGO:0300999.8CBFB, RUNX1
5stem cell differentiationGO:0488639.8RUNX2, KIT
6T cell differentiationGO:0302179.7KIT, RUNX2
7visual learningGO:0085429.7HRAS, KIT
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.6KIT, JAK2
9positive regulation of MAP kinase activityGO:0434069.5FLT3, HRAS
10cell maturationGO:0484699.5CBFB, RUNX2
11myeloid progenitor cell differentiationGO:0023189.5KIT, FLT3, RUNX1
12hemopoiesisGO:0300979.5KIT, FLT3, RUNX1
13positive regulation of MAPK cascadeGO:0434109.5FLT3, KIT, HRAS
14positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.5KIT, JAK2
15erythrocyte differentiationGO:0302189.5JAK2, KIT
16positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3KIT, JAK2
17positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.2KIT, JAK2, FLT3
18peptidyl-tyrosine phosphorylationGO:0181089.2KIT, JAK2, FLT3
19protein autophosphorylationGO:0467779.2FLT3, JAK2, KIT
20cytokine-mediated signaling pathwayGO:0192219.1FLT3, JAK2, KIT
21osteoblast differentiationGO:0016499.1CBFB, RUNX2
22positive regulation of cell migrationGO:0303359.1HRAS, KIT, JAK2
23activation of MAPKK activityGO:0001869.0HRAS, JAK2
24negative regulation of cell proliferationGO:0082858.8HRAS, JAK2, FLT3
25positive regulation of cell proliferationGO:0082848.1RUNX2, FLT3, JAK2, KIT, HRAS

Molecular functions related to Core Binding Factor Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.6FLT3, KIT
2repressing transcription factor bindingGO:0704919.3RUNX2, RUNX1
3phosphatidylinositol 3-kinase bindingGO:0435489.3JAK2, FLT3
4protein homodimerization activityGO:0428039.2KIT, FLT3, RUNX1
5protein tyrosine kinase activityGO:0047139.0KIT, JAK2
6ATP bindingGO:0055247.9KIT, JAK2, FLT3, RUNX2, RUNX1
7protein bindingGO:0055156.9RUNX1, RUNX2, FLT3, JAK2, CBFB, KIT

Products for genes affiliated with Core Binding Factor Acute Myeloid Leukemia

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  • Antibodies
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Sources for Core Binding Factor Acute Myeloid Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet