MCID: CRN023
MIFTS: 20

Corneal Deposit

Categories: Eye diseases

Aliases & Classifications for Corneal Deposit

MalaCards integrated aliases for Corneal Deposit:

Name: Corneal Deposit 12 51 69
Deposits - Cornea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11547
ICD10 32 H18.00
ICD9CM 34 371.10
UMLS 69 C0162281

Summaries for Corneal Deposit

MalaCards based summary : Corneal Deposit, also known as deposits - cornea, is related to corneal argyrosis and corneal dystrophy. An important gene associated with Corneal Deposit is TGFBI (Transforming Growth Factor Beta Induced). The drugs Cysteamine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Related Diseases for Corneal Deposit

Diseases related to Corneal Deposit via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 corneal argyrosis 11.2
2 corneal dystrophy 10.0
3 keratopathy 9.8
4 fabry disease 9.6
5 cataract 9.6
6 recurrent corneal erosion 9.6
7 giant papillary conjunctivitis 9.6
8 papillary conjunctivitis 9.6
9 conjunctivitis 9.6
10 acquired immunodeficiency syndrome 9.6
11 keratoconjunctivitis 9.6
12 scleromyxedema 9.6
13 vernal keratoconjunctivitis 9.6

Graphical network of the top 20 diseases related to Corneal Deposit:



Diseases related to Corneal Deposit

Symptoms & Phenotypes for Corneal Deposit

Drugs & Therapeutics for Corneal Deposit

Drugs for Corneal Deposit (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cysteamine Approved, Investigational Phase 2,Phase 1 60-23-1 6058
2
Dopamine Approved Phase 2,Phase 1 51-61-6, 62-31-7 681
3
Methamphetamine Approved, Illicit Phase 2,Phase 1 537-46-2 10836
4
Nitisinone Approved, Investigational Phase 2 104206-65-7 115355
5 Adrenergic Agents Phase 2,Phase 1
6 Autonomic Agents Phase 2,Phase 1
7 Central Nervous System Stimulants Phase 2,Phase 1
8 Dopamine Agents Phase 2,Phase 1
9 Dopamine Uptake Inhibitors Phase 2,Phase 1
10 Neurotransmitter Agents Phase 2,Phase 1
11 Neurotransmitter Uptake Inhibitors Phase 2,Phase 1
12 Ophthalmic Solutions Phase 2,Phase 1
13 Peripheral Nervous System Agents Phase 2,Phase 1
14 Pharmaceutical Solutions Phase 2
15 Tetrahydrozoline Phase 2,Phase 1
16 Anti-Infective Agents Phase 2
17 Antimalarials Phase 2
18 Antiparasitic Agents Phase 2
19 Antiprotozoal Agents Phase 2
20 tafenoquine Phase 2
21 tyrosine Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ophthalmic Findings During 10-year Enzyme Substitution of Danish Fabry Patients. Completed NCT01997489 Phase 4 Enzyme replacement
2 Cysteamine Eye Drops to Treat Corneal Crystals in Cystinosis Completed NCT00001213 Phase 2 Cysteamine
3 Long-Term Study of Nitisinone to Treat Alkaptonuria Completed NCT00107783 Phase 2 Nitisinone (NTBC)
4 Long-Term Safety Study of Tafenoquine Recruiting NCT03320174 Phase 2 Tafenoquine
5 New Cysteamine Eye Drops Formulation to Treat Corneal Crystals in Cystinosis Completed NCT00001736 Phase 1 Cysteamine
6 Randomized Study of New Formulation Ophthalmic Cysteamine Hydrochloride for Corneal Cystine Accumulation in Patients With Cystinosis Completed NCT00010426 cysteamine hydrochloride

Search NIH Clinical Center for Corneal Deposit

Genetic Tests for Corneal Deposit

Anatomical Context for Corneal Deposit

MalaCards organs/tissues related to Corneal Deposit:

38
Eye

Publications for Corneal Deposit

Articles related to Corneal Deposit:

(show all 16)
# Title Authors Year
1
Prominent regression of corneal deposits in Fabry disease 16A years after initiation of enzyme replacement therapy. ( 28834375 )
2017
2
Vortex Pattern of Corneal Deposits in Granular Corneal Dystrophy Associated With the p.(Arg555Trp) Mutation in TGFBI. ( 28060069 )
2017
3
Vortex Pattern of Corneal Deposits in Granular Corneal Dystrophy Associated With the p.(ArgR555WTrp) Mutation in TGFBI. ( 27741017 )
2016
4
Corneal deposit after topical ciprofloxacin as postoperative medication after cataract surgery. ( 25103659 )
2014
5
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. ( 23132456 )
2013
6
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. ( 22155582 )
2012
7
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy and atypical corneal immunoglobulin deposition in a patient with dysproteinemia. ( 21099423 )
2011
8
Corneal deposit of ciprofloxacin after laser assisted subepithelial keratomileusis procedure: a case report. ( 20634934 )
2010
9
Rifabutin corneal deposits in a patient with acquired immunodeficiency syndrome: in vivo confocal microscopy investigation. ( 19396800 )
2009
10
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy. ( 19574898 )
2009
11
Comparison of corneal deposits after LASIK and PRK in eyes with granular corneal dystrophy type II. ( 18500090 )
2008
12
Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis. ( 12714416 )
2003
13
Atypical vortex pattern of corneal deposits in granular corneal dystrophy. ( 14576527 )
2003
14
Unusual corneal deposit after the topical use of cyclosporine as eyedrops. ( 11078849 )
2000
15
Giant papillary conjunctivitis associated with elevated corneal deposits. ( 1706653 )
1990
16
Scleromyxedema with corneal deposits. ( 3684209 )
1987

Variations for Corneal Deposit

Expression for Corneal Deposit

Search GEO for disease gene expression data for Corneal Deposit.

Pathways for Corneal Deposit

GO Terms for Corneal Deposit

Sources for Corneal Deposit

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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