MCID: CRN023
MIFTS: 20

Corneal Deposit

Categories: Eye diseases

Aliases & Classifications for Corneal Deposit

MalaCards integrated aliases for Corneal Deposit:

Name: Corneal Deposit 12 52 69
Deposits - Cornea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11547
ICD10 33 H18.00
ICD9CM 35 371.10
UMLS 69 C0162281

Summaries for Corneal Deposit

MalaCards based summary : Corneal Deposit, also known as deposits - cornea, is related to corneal argyrosis and corneal dystrophy. An important gene associated with Corneal Deposit is TGFBI (Transforming Growth Factor Beta Induced). The drugs Difluprednate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial.

Related Diseases for Corneal Deposit

Diseases related to Corneal Deposit via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 corneal argyrosis 10.9
2 corneal dystrophy 9.9
3 keratopathy 9.7
4 giant papillary conjunctivitis 9.6
5 papillary conjunctivitis 9.6
6 conjunctivitis 9.6
7 acquired immunodeficiency syndrome 9.6
8 keratoconjunctivitis 9.6
9 scleromyxedema 9.6
10 vernal keratoconjunctivitis 9.6
11 fabry disease 9.6
12 cataract 9.6
13 recurrent corneal erosion 9.6

Graphical network of the top 20 diseases related to Corneal Deposit:



Diseases related to Corneal Deposit

Symptoms & Phenotypes for Corneal Deposit

Drugs & Therapeutics for Corneal Deposit

Drugs for Corneal Deposit (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Difluprednate Approved Phase 4 23674-86-4 443936
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Bevacizumab Approved, Investigational Phase 4 216974-75-3
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4,Phase 2,Phase 1
9 Fluprednisolone Phase 4
10 Gastrointestinal Agents Phase 4
11 glucocorticoids Phase 4
12 Hormone Antagonists Phase 4
13 Hormones Phase 4
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
15 Methylprednisolone acetate Phase 4
16 Methylprednisolone Hemisuccinate Phase 4
17 Neuroprotective Agents Phase 4
18 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
19 Prednisolone acetate Phase 4
20 Prednisolone hemisuccinate Phase 4
21 Prednisolone phosphate Phase 4
22 Protective Agents Phase 4
23 Pharmaceutical Solutions Phase 4,Phase 2
24 Anesthetics Phase 4
25 Angiogenesis Inhibitors Phase 4
26 Angiogenesis Modulating Agents Phase 4
27 Antibodies Phase 4,Phase 1
28 Antibodies, Monoclonal Phase 4
29 Immunoglobulins Phase 4,Phase 1
30
Cysteamine Approved, Investigational Phase 2,Phase 1 60-23-1 6058
31
Dopamine Approved Phase 2,Phase 1 51-61-6, 62-31-7 681
32
Methamphetamine Approved, Illicit Phase 2,Phase 1 537-46-2 10836
33
Nitisinone Approved, Investigational Phase 2 104206-65-7 115355
34 Adrenergic Agents Phase 2,Phase 1
35 Central Nervous System Stimulants Phase 2,Phase 1
36 Dopamine Agents Phase 2,Phase 1
37 Dopamine Uptake Inhibitors Phase 2,Phase 1
38 Neurotransmitter Agents Phase 2,Phase 1
39 Neurotransmitter Uptake Inhibitors Phase 2,Phase 1
40 Ophthalmic Solutions Phase 2,Phase 1
41 Tetrahydrozoline Phase 2,Phase 1
42 tyrosine Nutraceutical Phase 2
43
Dipivefrin Approved 52365-63-6 3105
44 Muramidase
45 Adrenergic Agonists

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Ophthalmic Findings During 10-year Enzyme Substitution of Danish Fabry Patients. Completed NCT01997489 Phase 4 Enzyme replacement
2 Study of Difluprednate vs. Prednisolone Acetate on Visual Acuity, and Corneal Edema Following Cataract Surgery. Completed NCT01244334 Phase 4 Difluprednate ophthalmic emulsion 0.05%;Prednisolone acetate 1%
3 Strategies for Management of Corneal Neovascularisation Not yet recruiting NCT02594423 Phase 4 Bevacizumab
4 Cysteamine Eye Drops to Treat Corneal Crystals in Cystinosis Completed NCT00001213 Phase 2 Cysteamine
5 Long-Term Study of Nitisinone to Treat Alkaptonuria Completed NCT00107783 Phase 2 Nitisinone (NTBC)
6 Treatment of Corneal Neovascularization With Topical Pazopanib Completed NCT01257750 Phase 1, Phase 2 Pazopanib (5mg/ml)
7 New Cysteamine Eye Drops Formulation to Treat Corneal Crystals in Cystinosis Completed NCT00001736 Phase 1 Cysteamine
8 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
9 Randomized Study of New Formulation Ophthalmic Cysteamine Hydrochloride for Corneal Cystine Accumulation in Patients With Cystinosis Completed NCT00010426 cysteamine hydrochloride
10 Efficacy of Topical Cysteamine in Nephropathic Cyctinosis Completed NCT02766855 Cysteamine
11 Hybrid SA RGP Center/S-H Skirt Daily Wear 90 Day Multicenter Study Completed NCT00804505
12 Clinical and Laboratory Study of Lysozyme Deposition on Daily Disposable Contact Lenses Completed NCT02365298
13 Evaluation of Disinfecting Solutions and Protein Remover With a Silicone Hydrogel Lens Completed NCT00754338 Alcon Opti-Free® RepleniSH® with Supraclens®;Alcon Opti-Free® RepleniSH®;B&L ReNu MultiPlus™
14 Paraoxonase and HDL Qualities in Glycaemia and Inflammation Recruiting NCT02169518
15 Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT Not yet recruiting NCT02542644

Search NIH Clinical Center for Corneal Deposit

Genetic Tests for Corneal Deposit

Anatomical Context for Corneal Deposit

MalaCards organs/tissues related to Corneal Deposit:

39
Eye, Endothelial

Publications for Corneal Deposit

Articles related to Corneal Deposit:

(show all 16)
id Title Authors Year
1
Vortex Pattern of Corneal Deposits in Granular Corneal Dystrophy Associated With the p.(Arg555Trp) Mutation in TGFBI. ( 28060069 )
2017
2
Prominent regression of corneal deposits in Fabry disease 16A years after initiation of enzyme replacement therapy. ( 28834375 )
2017
3
Vortex Pattern of Corneal Deposits in Granular Corneal Dystrophy Associated With the p.(ArgR555WTrp) Mutation in TGFBI. ( 27741017 )
2016
4
Corneal deposit after topical ciprofloxacin as postoperative medication after cataract surgery. ( 25103659 )
2014
5
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. ( 23132456 )
2013
6
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. ( 22155582 )
2012
7
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy and atypical corneal immunoglobulin deposition in a patient with dysproteinemia. ( 21099423 )
2011
8
Corneal deposit of ciprofloxacin after laser assisted subepithelial keratomileusis procedure: a case report. ( 20634934 )
2010
9
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy. ( 19574898 )
2009
10
Rifabutin corneal deposits in a patient with acquired immunodeficiency syndrome: in vivo confocal microscopy investigation. ( 19396800 )
2009
11
Comparison of corneal deposits after LASIK and PRK in eyes with granular corneal dystrophy type II. ( 18500090 )
2008
12
Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis. ( 12714416 )
2003
13
Atypical vortex pattern of corneal deposits in granular corneal dystrophy. ( 14576527 )
2003
14
Unusual corneal deposit after the topical use of cyclosporine as eyedrops. ( 11078849 )
2000
15
Giant papillary conjunctivitis associated with elevated corneal deposits. ( 1706653 )
1990
16
Scleromyxedema with corneal deposits. ( 3684209 )
1987

Variations for Corneal Deposit

Expression for Corneal Deposit

Search GEO for disease gene expression data for Corneal Deposit.

Pathways for Corneal Deposit

GO Terms for Corneal Deposit

Sources for Corneal Deposit

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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