MCID: CRN023
MIFTS: 23

Corneal Deposit malady

Summaries for Corneal Deposit

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64Wikipedia, 33MalaCards
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Wikipedia:64 The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.... more...

MalaCards: Corneal Deposit, also known as corneal deposit, unspecified, is related to corneal granular dystrophy and corneal argyrosis. An important gene associated with Corneal Deposit is TGFBI (transforming growth factor, beta-induced, 68kDa).

Aliases & Classifications for Corneal Deposit

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

corneal deposit 8 45 61
corneal deposit, unspecified 8
unspecified corneal deposit 8
deposits - cornea 8


External Ids:

Disease Ontology8 DOID:11547
ICD9CM27 371.10

Related Diseases for Corneal Deposit

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Corneal Deposit via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1corneal granular dystrophy10.2
2corneal argyrosis10.0
3giant papillary conjunctivitis10.0
4acquired immunodeficiency syndrome10.0
5recurrent corneal erosion10.0
6micro syndrome10.0
7scleromyxedema10.0
8vernal keratoconjunctivitis10.0

Graphical network of diseases related to Corneal Deposit:



Diseases related to corneal deposit

Clinical Features for Corneal Deposit

Drugs & Therapeutics for Corneal Deposit

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Corneal Deposit

Search CenterWatch for Corneal Deposit

Genetic Tests for Corneal Deposit

Anatomical Context for Corneal Deposit

Animal Models for Corneal Deposit or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Corneal Deposit

Sources:
51PubMed
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Articles related to Corneal Deposit:

(show all 41)
idTitleAuthorsYear
1
Subepithelial corneal immunoglobulin deposition as a manifestation of multiple myeloma: a case report and literature review. (24211225)
2014
2
Unilateral Variant of Late-Onset Lattice Corneal Dystrophy With the Pro501Thr Mutation in the TGFBI Gene Without Deposits in the Unaffected Cornea Using Confocal Microscopy. (23884333)
2013
3
Recurrence of corneal neovascularization associated with lipid deposition after subconjunctival injection of bevacizumab. (24055900)
2013
4
Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid deposits. (23592924)
2013
5
Rapid corneal adrenochrome deposition from topical ibopamine in the setting of infectious keratitis. (23079754)
2013
6
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. (23132456)
2013
7
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. (22155582)
2012
8
Follow-up to "central and peripheral corneal iron deposits after implantation of a small-aperture corneal inlay for correction of presbyopia". (22150430)
2011
9
Subconjunctival injection of bevacizumab in the treatment of corneal neovascularization associated with lipid deposition. (20847676)
2011
10
Central and peripheral corneal iron deposits after implantation of a small-aperture corneal inlay for correction of presbyopia. (21815605)
2011
11
Characteristic features of granular deposit formation in granular corneal dystrophy type 2. (21217525)
2011
12
Analysis of deposit depth and morphology in granular corneal dystrophy type 2 using fourier domain optical coherence tomography. (21242786)
2011
13
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy and atypical corneal immunoglobulin deposition in a patient with dysproteinemia. (21099423)
2011
14
Granular and lattice deposits in corneal dystrophy caused by R124C mutation of TGFBIp. (20697279)
2010
15
Corneal deposit of ciprofloxacin after laser assisted subepithelial keratomileusis procedure: a case report. (20634934)
2010
16
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy. (19574898)
2009
17
Rifabutin corneal deposits in a patient with acquired immunodeficiency syndrome: in vivo confocal microscopy investigation. (19396800)
2009
18
Deposits of transforming growth factor-beta-induced protein in granular corneal dystrophy type II after LASIK. (18245963)
2008
19
Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3-D cultures. (18624285)
2008
20
Comparison of corneal deposits after LASIK and PRK in eyes with granular corneal dystrophy type II. (18500090)
2008
21
A clinical and histopathologic examination of accelerated TGFBIp deposition after LASIK in combined granular-lattice corneal dystrophy. (17317389)
2007
22
Corneal copper deposition associated with chronic lymphocytic leukemia. (16815276)
2006
23
Systemic investigation of keratoepithelin deposits in TGFBI/BIGH3-related corneal dystrophy. (16710170)
2006
24
No pathogenic mutations identified in the TGFBI gene in polymorphic corneal amyloid deposition. (16670477)
2006
25
Hereditary lattice corneal dystrophy is associated with corneal amyloid deposits enclosing C-terminal fragments of keratoepithelin. (15790870)
2005
26
Morphometric analysis of deposits in granular and lattice corneal dystrophy: histopathologic implications for phototherapeutic keratectomy. (15097134)
2004
27
Atypical vortex pattern of corneal deposits in granular corneal dystrophy. (14576527)
2003
28
Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis. (12714416)
2003
29
Unusual superficial variant of granular corneal dystrophy with amyloid deposition. (12583796)
2003
30
Differences in amyloid deposition in primary and recurrent corneal lattice dystrophy type 1. (11917182)
2002
31
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
32
Unusual corneal deposit after the topical use of cyclosporine as eyedrops. (11078849)
2000
33
Acute unilateral corneal immunoprotein deposition in IgM monoclonal gammopathy. (10636428)
2000
34
Quantitative analysis of lipid deposits from Schnyder's corneal dystrophy. (9640198)
1998
35
Corneal ulcer associated with deposits of norfloxacin. (9467459)
1998
36
Long-term contact lens wear induces a corneal degeneration with microdot deposits in the corneal stroma. (9373122)
1997
37
Eosinophil granule major basic protein deposition in corneal ulcers associated with vernal keratoconjunctivitis. (8488918)
1993
38
Giant papillary conjunctivitis associated with elevated corneal deposits. (1706653)
1990
39
Spatial and temporal sequence of corneal crystal deposition in nephropathic cystinosis. (3688102)
1987
40
Scleromyxedema with corneal deposits. (3684209)
1987
41
Lack of evidence for protein AA reactivity in amyloid deposits of lattice corneal dystrophy and amyloid corneal degeneration. (6383050)
1984

Genetic Variations for Corneal Deposit

Expression for genes affiliated with Corneal Deposit

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Deposit

Search GEO for disease gene expression data for Corneal Deposit.

Pathways for genes affiliated with Corneal Deposit

Compounds for genes affiliated with Corneal Deposit

GO Terms for genes affiliated with Corneal Deposit

Sources:
16Gene Ontology
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Cellular components related to Corneal Deposit according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1TGFBI, HTRA1
2extracellular matrixGO:0310128.8TGFBI, HTRA1

Products for genes affiliated with Corneal Deposit

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corneal Deposit

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet