MCID: CRN023
MIFTS: 21

Corneal Deposit malady

Categories: Eye diseases

Aliases & Classifications for Corneal Deposit

Aliases & Descriptions for Corneal Deposit:

Name: Corneal Deposit 12 52 69
Deposits - Cornea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11547
ICD10 33 H18.00
ICD9CM 35 371.10
UMLS 69 C0162281

Summaries for Corneal Deposit

MalaCards based summary : Corneal Deposit, also known as deposits - cornea, is related to corneal argyrosis and corneal dystrophy. An important gene associated with Corneal Deposit is TGFBI (Transforming Growth Factor Beta Induced). The drugs Difluprednate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye.

Related Diseases for Corneal Deposit

Diseases related to Corneal Deposit via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
id Related Disease Score Top Affiliating Genes
1 corneal argyrosis 11.1
2 corneal dystrophy 9.9
3 corneal dystrophy, lattice type iiia 9.8 TGFBI XK
4 keratopathy 9.7
5 fuchs' endothelial dystrophy 9.7 TGFBI XK
6 cataract 9.6
7 recurrent corneal erosion 9.6
8 giant papillary conjunctivitis 9.6
9 papillary conjunctivitis 9.6
10 conjunctivitis 9.6
11 acquired immunodeficiency syndrome 9.6
12 keratoconjunctivitis 9.6
13 scleromyxedema 9.6
14 vernal keratoconjunctivitis 9.6

Graphical network of the top 20 diseases related to Corneal Deposit:



Diseases related to Corneal Deposit

Symptoms & Phenotypes for Corneal Deposit

Drugs & Therapeutics for Corneal Deposit

Drugs for Corneal Deposit (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Difluprednate Approved Phase 4 23674-86-4 443936
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Ephedrine Approved Phase 4 299-42-3 9294
5
Pseudoephedrine Approved Phase 4 90-82-4 7028
6
Bevacizumab Approved, Investigational Phase 4 216974-75-3
7 Antiemetics Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Antineoplastic Agents, Hormonal Phase 4
10 Autonomic Agents Phase 4,Phase 2,Phase 1
11 Fluprednisolone Phase 4
12 Gastrointestinal Agents Phase 4
13 glucocorticoids Phase 4
14 Hormone Antagonists Phase 4
15 Hormones Phase 4
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
17 Methylprednisolone acetate Phase 4
18 Methylprednisolone Hemisuccinate Phase 4
19 Neuroprotective Agents Phase 4
20 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
21 Prednisolone acetate Phase 4
22 Prednisolone hemisuccinate Phase 4
23 Prednisolone phosphate Phase 4
24 Protective Agents Phase 4
25 Lubricant Eye Drops Phase 4
26 Nasal Decongestants Phase 4
27 Ophthalmic Solutions Phase 4,Phase 2,Phase 1
28 Pharmaceutical Solutions Phase 4,Phase 2
29 Respiratory System Agents Phase 4
30 Tetrahydrozoline Phase 4,Phase 2,Phase 1
31 Vasoconstrictor Agents Phase 4
32 Anesthetics Phase 4
33 Angiogenesis Inhibitors Phase 4
34 Angiogenesis Modulating Agents Phase 4
35 Antibodies Phase 4,Phase 1
36 Antibodies, Monoclonal Phase 4
37 Immunoglobulins Phase 4,Phase 1
38
Cysteamine Approved, Investigational Phase 2,Phase 1 60-23-1 6058
39
Dopamine Approved Phase 2,Phase 1 51-61-6, 62-31-7 681
40
Methamphetamine Approved, Illicit Phase 2,Phase 1 537-46-2 10836
41
Nitisinone Approved, Investigational Phase 2 104206-65-7 115355
42 Adrenergic Agents Phase 2,Phase 1
43 Central Nervous System Stimulants Phase 2,Phase 1
44 Dopamine Agents Phase 2,Phase 1
45 Dopamine Uptake Inhibitors Phase 2,Phase 1
46 Neurotransmitter Agents Phase 2,Phase 1
47 Neurotransmitter Uptake Inhibitors Phase 2,Phase 1
48 tyrosine Nutraceutical Phase 2
49
Dipivefrin Approved 52365-63-6 3105
50 Muramidase

Interventional clinical trials:

(show all 33)
id Name Status NCT ID Phase
1 Ophthalmic Findings During 10-year Enzyme Substitution of Danish Fabry Patients. Completed NCT01997489 Phase 4
2 Study of Difluprednate vs. Prednisolone Acetate on Visual Acuity, and Corneal Edema Following Cataract Surgery. Completed NCT01244334 Phase 4
3 Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism Completed NCT01965288 Phase 4
4 Daily Disposable Comparison Study Completed NCT02094677 Phase 4
5 Efficacy Study of a New Eyedrop on Silicone Hydrogel Contact Lens Wearers With Dry Eye Complaints Completed NCT01543061 Phase 4
6 Strategies for Management of Corneal Neovascularisation Not yet recruiting NCT02594423 Phase 4
7 Cysteamine Eye Drops to Treat Corneal Crystals in Cystinosis Completed NCT00001213 Phase 2
8 Long-Term Study of Nitisinone to Treat Alkaptonuria Completed NCT00107783 Phase 2
9 Treatment of Corneal Neovascularization With Topical Pazopanib Completed NCT01257750 Phase 1, Phase 2
10 New Cysteamine Eye Drops Formulation to Treat Corneal Crystals in Cystinosis Completed NCT00001736 Phase 1
11 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1
12 Randomized Study of New Formulation Ophthalmic Cysteamine Hydrochloride for Corneal Cystine Accumulation in Patients With Cystinosis Completed NCT00010426
13 Efficacy of Topical Cysteamine in Nephropathic Cyctinosis Completed NCT02766855
14 Hybrid SA RGP Center/S-H Skirt Daily Wear 90 Day Multicenter Study Completed NCT00804505
15 Clinical and Laboratory Study of Lysozyme Deposition on Daily Disposable Contact Lenses Completed NCT02365298
16 Evaluation of Disinfecting Solutions and Protein Remover With a Silicone Hydrogel Lens Completed NCT00754338
17 A Multi-Center Study Comparing the Clinical Performance of Two Silicone Hydrogel Lenses Over 1 Month of Daily Wear Completed NCT01952665
18 Clinical Validation of Biofinity Toric MTO (Made To Order) Lenses Completed NCT02185105
19 Bilateral Dispensing Clinical Trial of Stenfilcon A Against Etafilcon A for Astigmatism Completed NCT02410824
20 A Clinical Assessment of the Hemacopolymer Daily Disposable Limbal Ring Soft Contact Lens Completed NCT01965262
21 Dispensing Study for a New Study Test Lens Completed NCT02642991
22 One Week Assessment of a Lens With a Novel Optical Profile Completed NCT02642354
23 One Week Assessment of a New Study Test Lens Completed NCT02642341
24 Multi-Center Clinical Evaluation of Two Reusable Soft Contact Lenses Completed NCT02542072
25 A Dispensing Clinical Trial of a Study Test Silicone Hydrogel Lens Against Control Lens Over 1 Week Completed NCT02500368
26 Evaluation of an Investigational Multi-Purpose Disinfecting Solution for the Care of Silicone Hydrogel Soft Contact Lenses Completed NCT00382902
27 A Clinical Comparison of Three Soft Daily Disposable Contact Lenses Completed NCT02920983
28 Evaluation of an Investigational Multi-Purpose Disinfecting Solution for the Care of Soft Contact Lenses in Symptomatic Patients Completed NCT00382603
29 Paraoxonase and HDL Qualities in Glycaemia and Inflammation Recruiting NCT02169518
30 Performance Comparison Between Comfilcon A and Senofilcon C Lenses Active, not recruiting NCT02920957
31 The Clinical Comparison of Narafilcon A and Stenfilcon A Contact Lenses Active, not recruiting NCT02920970
32 Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT Not yet recruiting NCT02542644
33 Enzyme Replacement Therapy in Fabry Disease Terminated NCT00149318

Search NIH Clinical Center for Corneal Deposit

Genetic Tests for Corneal Deposit

Anatomical Context for Corneal Deposit

MalaCards organs/tissues related to Corneal Deposit:

39
Eye

Publications for Corneal Deposit

Articles related to Corneal Deposit:

(show all 15)
id Title Authors Year
1
Vortex Pattern of Corneal Deposits in Granular Corneal Dystrophy Associated With the p.(Arg555Trp) Mutation in TGFBI. ( 28060069 )
2017
2
Vortex Pattern of Corneal Deposits in Granular Corneal Dystrophy Associated With the p.(ArgR555WTrp) Mutation in TGFBI. ( 27741017 )
2016
3
Corneal deposit after topical ciprofloxacin as postoperative medication after cataract surgery. ( 25103659 )
2014
4
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. ( 23132456 )
2013
5
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. ( 22155582 )
2012
6
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy and atypical corneal immunoglobulin deposition in a patient with dysproteinemia. ( 21099423 )
2011
7
Corneal deposit of ciprofloxacin after laser assisted subepithelial keratomileusis procedure: a case report. ( 20634934 )
2010
8
Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy. ( 19574898 )
2009
9
Rifabutin corneal deposits in a patient with acquired immunodeficiency syndrome: in vivo confocal microscopy investigation. ( 19396800 )
2009
10
Comparison of corneal deposits after LASIK and PRK in eyes with granular corneal dystrophy type II. ( 18500090 )
2008
11
Atypical vortex pattern of corneal deposits in granular corneal dystrophy. ( 14576527 )
2003
12
Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis. ( 12714416 )
2003
13
Unusual corneal deposit after the topical use of cyclosporine as eyedrops. ( 11078849 )
2000
14
Giant papillary conjunctivitis associated with elevated corneal deposits. ( 1706653 )
1990
15
Scleromyxedema with corneal deposits. ( 3684209 )
1987

Variations for Corneal Deposit

Expression for Corneal Deposit

Search GEO for disease gene expression data for Corneal Deposit.

Pathways for Corneal Deposit

GO Terms for Corneal Deposit

Sources for Corneal Deposit

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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