MCID: CRN024
MIFTS: 54

Corneal Disease malady

Eye diseases category
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Summaries for Corneal Disease

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MedlinePlus:33 Your cornea is the outermost layer of your eye. it is clear and shaped like a dome. the cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. it also helps your eye to focus. if you wear contact lenses, they float on top of your corneas. problems with the cornea include refractive errors allergies infections injuries dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material treatments of corneal disorders include medicines, corneal transplantation, and corneal laser surgery. nih: national eye institute

MalaCards based summary: Corneal Disease, also known as corneal disorders, is related to bullous keratopathy and cataract. An important gene associated with Corneal Disease is KRT12 (keratin 12), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Colorectal Cancer Metastasis. The drug deferoxamine mesylate and the compounds uva 1 and glycosaminoglycan have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and small intestine, and related mouse phenotypes are respiratory system and tumorigenesis.

Wikipedia:65 The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.... more...

Aliases & Classifications for Corneal Disease

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Corneal Disease, Aliases & Descriptions:

Name: Corneal Disease 8
Corneal Disorders 33 62
 
Corneal Diseases 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:10124
ICD9CM27 371.9
MeSH34 D003316
NCIt39 C26731
ICD1025 H17.9

Related Diseases for Corneal Disease

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Diseases related to Corneal Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1bullous keratopathy30.4IL1A, TGFB2
2cataract30.4TGFBI, TGFB2, AKR1B1, GJB2
3arthritis30.3IL1A, TIMP1
4keratoconus29.3SP1, TIMP1, TGFBI, MMP1, GSN, KRT12
5meesmann corneal dystrophy10.5KRT12, KRT3
6oral submucous fibrosis10.4TIMP1, MMP1
7polyneuropathy10.4GSN, AKR1B1
8recurrent corneal erosion10.4KRT12, TGFBI
9periodontitis10.3IL1A
10lattice corneal dystrophy type 110.3TGFBI, GSN
11amyloidosis corneal10.3GSN, TGFBI
12herpes simplex10.3
13lattice corneal dystrophy10.3TGFBI, GSN
14cataract 4, multiple types10.3TGFB2, AKR1B1
15abdominal aortic aneurysm10.3TIMP1, MMP1
16aggressive periodontitis10.3IL1A, MMP1
17open-angle glaucoma10.3MMP1, TGFB2
18oral lichen planus10.3MMP1, IL1A
19hypertrophic scars10.3TIMP1, MMP1
20middle ear cholesteatoma10.3MMP1, IL1A
21hepatitis c10.3TLR3, TIMP1, MMP1
22diabetic polyneuropathy10.2NGF, AKR1B1
23keratitis10.2
24glomerulosclerosis10.2TIMP1, AKR1B1, LCAT
25diabetic autonomic neuropathy10.2AKR1B1, NGF
26psoriatic arthritis10.2MMP1, IL1A
27diabetic neuropathy10.2AKR1B1, NGF
28pulpitis10.2IL1A, MMP1, TIMP1
29gingival overgrowth10.2TIMP1, MMP1, IL1A
30gingivitis10.2IL1A, MMP1, TIMP1
31proliferative vitreoretinopathy10.2TGFB2, TIMP1
32pulmonary fibrosis10.2MMP1, TGFB2, TIMP1
33synovitis10.2TIMP1, MMP1, IL1A
34autonomic neuropathy10.2AKR1B1, NGF
35periodontal disease10.2TIMP1, MMP1, IL1A
36amyloid tumor10.2TGFBI, GSN, KRT12, KRT3
37spiradenoma10.2NGF
38endometriosis10.1IL1A, MMP1, TIMP1
39limbal stem cell deficiency10.1
40renal fibrosis10.1TGFB2, TIMP1
41sensory peripheral neuropathy10.1NGF, AKR1B1
42skin disease10.1GJB2, IL1A, MMP1
43breast cancer10.1GJB2, GSN, SP1
44keloids10.1MMP1, TGFB2, SP1
45ulcerative colitis10.1TFF3, TLR3, MMP1, IL1A
46keratopathy10.1
47keratoconjunctivitis10.1
48blindness10.1
49conjunctivochalasis10.1MMP1, TIMP1, PTGER3
50corneal dystrophy10.1TGFBI, CHST6, GSN, KRT12, KRT3

Graphical network of the top 20 diseases related to Corneal Disease:



Diseases related to corneal disease

Symptoms for Corneal Disease

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Drugs & Therapeutics for Corneal Disease

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Drug clinical trials:

Search ClinicalTrials for Corneal Disease

Search NIH Clinical Center for Corneal Disease

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Corneal Disease

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Anatomical Context for Corneal Disease

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MalaCards organs/tissues related to Corneal Disease:

32
Eye, T cells, Small intestine, Colon, Testes

Animal Models for Corneal Disease or affiliated genes

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MGI Mouse Phenotypes related to Corneal Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7GSN, TGFB2, TIMP1, TLR3, SP1
2MP:00020068.5TLR3, TIMP1, TGFBI, MMP1, IL1A
3MP:00053918.0SP1, NGF, TGFB2, AKR1B1, LCAT, GJB2
4MP:00053977.4SP1, TLR3, TIMP1, TGFBI, TGFB2, IL1A
5MP:00053876.5TIMP1, PTGER3, TLR3, TFF3, TGFBI, TGFB2
6MP:00053856.4SP1, TLR3, NGF, PTGER3, TIMP1, TGFB2
7MP:00107686.4SP1, TLR3, NGF, PTGER3, TIMP1, TGFBI
8MP:00053764.9GJB2, SP1, TFF3, TLR3, NGF, PTGER3

Publications for Corneal Disease

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Articles related to Corneal Disease:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Mosaic Chromosome 18q Partial Deletion Syndrome with Bilateral Full-thickness Corneal Disease: Surgical Intervention and Histopathology. (24024746)
2013
2
Cataract surgery in patients with corneal disease. (23197265)
2013
3
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice. (22647700)
2012
4
Pilot Study for OCT Guided Design and Fit of a Prosthetic Device for Treatment of Corneal Disease. (23316338)
2012
5
Correlation of clinical and pathologic diagnoses of corneal disease in penetrating keratoplasties in Vancouver: a 10-year review. (22333843)
2012
6
Histopathology and treatment of corneal disease in keratitis, ichthyosis, and deafness (KID) syndrome. (19590522)
2010
7
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. (20007286)
2010
8
Collagen cross-linking: a new treatment paradigm in corneal disease - a review. (20398104)
2010
9
Disruption of CFTR-dependent lipid rafts reduces bacterial levels and corneal disease in a murine model of Pseudomonas aeruginosa keratitis. (18326723)
2008
10
CD8(+) T cells control corneal disease following ocular infection with herpes simplex virus type 1. (15218191)
2004
11
Laser applications for corneal disease. (14604095)
2003
12
Applications of contact lens devices in the management of corneal disease. (14631391)
2003
13
Prospects for gene therapy in corneal disease. (14631395)
2003
14
Corneal disease in patients with chronic renal insufficiency undergoing hemodialysis. (11588419)
2001
15
Iatrogenic limbal stem cell deficiency: when glaucoma management contributes to corneal disease. (11740212)
2001
16
Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness). (11123754)
2000
17
Acremonium keratitis in a patient with herpetic neurotrophic corneal disease. (10726803)
2000
18
Management of coincident corneal disease and cataract. (10387322)
1999
19
An analysis of 1,001 blinding patients with corneal disease in 1960-1989. (12580077)
1998
20
Corneoscleral transplantation for end stage corneal disease. (9924332)
1998
21
Detection of interleukin-1 beta in the tear fluid of patients with corneal disease with or without conjunctival involvement. (9152805)
1997
22
High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation. (8627763)
1996
23
Changing patterns of corneal disease and associated vision loss at a rural African hospital following a training programme for traditional healers. (8949711)
1996
24
Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis. (8849537)
1995
25
Traditional eye medicine use among patients with corneal disease in rural Malawi. (7848973)
1994
26
Circulating cornea-specific antibodies in corneal disease and cornea transplantation. (8157180)
1994
27
Clinical and diagnostic use of in vivo confocal microscopy in patients with corneal disease. (8414403)
1993
28
Anterior corneal disease of epidermolysis bullosa simplex. (8470983)
1993
29
Compensatory epithelial hyperplasia in human corneal disease. (1484663)
1992
30
Endogenously produced interferon alpha protects mice from herpes simplex virus type 1 corneal disease. (1649898)
1991
31
Corneal disease in Africa. (1782163)
1991
32
Herpes simplex virus--induced destructive corneal disease. (2559859)
1989
33
Botulinum toxin A-induced protective ptosis in corneal disease. (3050691)
1988
34
Ophthalmology: viral corneal disease. (18749959)
1986
35
Diabetic corneal disease. (3155119)
1986
36
The prevalence of corneal disease in the coloured community of a Karoo town. (3992399)
1985
37
A new bandage lens for treatment of corneal disease: Softcon XT. (6509765)
1984
38
Inflammatory Terrien's marginal corneal disease. (7270631)
1981
39
Primary corneal disease in the dog and cat. (6251593)
1980
40
Destructive corneal disease in the connective tissue disorders. Comparison with an experimental animal model. (38536)
1978
41
Use of anti-inflammatory agents in destructive corneal disease. (382459)
1978
42
Neglected lid deformities causing progressive corneal disease. Surgical correction of entropion, trichiasis, marginal keratinization, and functional lid shortening. (1087767)
1976
43
The Bausch and Lomb "T" lens in the treatment of corneal disease. (1070889)
1976
44
The use of therapeutic soft contact lenses in corneal disease. (1152538)
1975
45
Complications in use of soft contact lenses in corneal disease. (4746087)
1973
46
A simple scheme for documenting corneal disease. (4127939)
1973
47
Topically applied steroids in corneal disease. II. The role of drug vehicle in stromal absorption of dexamethasone. (4634795)
1972
48
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
49
Diagnosing corneal disease. (5726393)
1968
50
Corneal disease. (5903646)
1966

Variations for Corneal Disease

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Expression for genes affiliated with Corneal Disease

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Expression patterns in normal tissues for genes affiliated with Corneal Disease

Search GEO for disease gene expression data for Corneal Disease.

Pathways for genes affiliated with Corneal Disease

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Pathways related to Corneal Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MMP1, TIMP1
29.5MMP1, TGFB2, TLR3
39.3TGFB2, MMP1, IL1A
4
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.2IL1A, TLR3, SP1
5
Show member pathways
9.1IL1A, TGFB2, TIMP1, TLR3
69.0SP1, NGF, IL1A
7
Show member pathways
8.6SP1, TLR3, TIMP1, TGFB2, IL1A

Compounds for genes affiliated with Corneal Disease

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Compounds related to Corneal Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1uva 1449.9IL1A, MMP1, TIMP1
2glycosaminoglycan449.2TIMP1, IL1A, MMP1, TGFB2
3sodium dodecylsulfate449.2IL1A, GSN, MMP1, LCAT
4rantes449.2TIMP1, MMP1, TGFB2, IL1A, TLR3
5matrigel449.1NGF, MMP1, TIMP1, TGFB2, GJB2
6vitamin a44 24 1111.1TIMP1, TGFB2, LCAT, MMP1, IL1A
7pdtc449.1NGF, MMP1, SP1, IL1A
8azathioprine44 2 50 1112.0SP1, NGF, TIMP1, GSN
9curcumin449.0MMP1, SP1, IL1A, AKR1B1, TIMP1
10tetracycline44 1110.0IL1A, SP1, NGF, MMP1
11n acetylcysteine449.0AKR1B1, SP1, MMP1, TIMP1, TGFB2
12ascorbic acid44 2410.0MMP1, AKR1B1, IL1A, LCAT, TGFB2
13egcg448.9TGFB2, TIMP1, SP1, IL1A, MMP1
14pge1448.9PTGER3, IL1A, MMP1, LCAT
15aspirin44 50 28 2411.8AKR1B1, TFF3, TIMP1, NGF, MMP1
16paclitaxel44 50 1110.8SP1, TIMP1, MMP1, GSN, IL1A
17dihydrotestosterone44 28 24 1111.8AKR1B1, TGFB2, NGF, SP1, GSN
18norepinephrine44 24 1110.8IL1A, AKR1B1, NGF, TIMP1, MMP1
19epinephrine44 24 1110.7SP1, NGF, MMP1, AKR1B1, IL1A
2012-o-tetradecanoylphorbol 13-acetate448.7SP1, IL1A, MMP1, TIMP1, NGF
21sb 20358044 619.7MMP1, TIMP1, IL1A, NGF, SP1
22tgf beta1448.7TIMP1, SP1, TGFB2, MMP1
23butyrate448.6TFF3, GSN, LCAT, TIMP1, SP1
24prostaglandin448.6TIMP1, MMP1, IL1A, TGFB2, PTGER3
25cyclosporin a44 28 6110.6IL1A, TIMP1, TGFB2, MMP1, AKR1B1, NGF
26paraffin448.6MMP1, TGFB2, GJB2, TFF3, TIMP1
27calcitriol44 61 24 1111.4NGF, TIMP1, SP1, IL1A, TGFB2, MMP1
28vitamin d448.4NGF, IL1A, TGFB2, SP1, TIMP1, GSN
29forskolin44 50 1110.3TGFB2, SP1, NGF, GJB2, IL1A
30h2o2448.3TFF3, SP1, TIMP1, AKR1B1, MMP1, IL1A
31prostacyclin448.3TIMP1, IL1A, PTGER3, NGF, SP1
32pd 98,059448.3SP1, TFF3, TIMP1, NGF, MMP1
33actinomycin d448.2IL1A, TIMP1, NGF, TFF3, SP1, AKR1B1
34genistein44 28 61 2 24 1113.1TIMP1, NGF, SP1, IL1A, MMP1, TGFB2
35cycloheximide448.1SP1, TGFB2, NGF, TIMP1, IL1A, AKR1B1
36estrogen448.0MMP1, LCAT, SP1, TFF3, TGFB2, TIMP1
37arginine448.0NGF, TIMP1, KRT12, AKR1B1, KRT3, SP1
38glutamate448.0LCAT, GSN, IL1A, TGFB2, TIMP1, NGF
39phosphatidylinositol447.9TGFB2, GSN, TIMP1, NGF, TLR3, TFF3
40dexamethasone44 50 28 1110.8LCAT, IL1A, MMP1, TGFB2, TIMP1, TLR3
41progesterone44 28 61 24 1111.8TIMP1, TFF3, PTGER3, TGFB2, IL1A, GJB2
42testosterone44 61 24 1110.8LCAT, GSN, SP1, IL1A, NGF, MMP1
43glutamine447.7TIMP1, TGFBI, SP1, NGF, TGFB2, AKR1B1
44retinoic acid44 248.6SP1, TIMP1, GSN, IL1A, MMP1, TGFB2
45vegf447.5IL1A, SP1, NGF, TIMP1, TGFB2, MMP1
46indomethacin44 28 61 1110.2TGFB2, TFF3, NGF, PTGER3, MMP1, AKR1B1
47pge2447.2AKR1B1, IL1A, MMP1, TGFB2, SP1, TIMP1
48cysteine447.0TFF3, LCAT, AKR1B1, MMP1, TGFB2, TGFBI
49serine446.9TGFBI, TIMP1, NGF, TLR3, SP1, TGFB2
50tyrosine446.8SP1, TFF3, TLR3, NGF, PTGER3, TIMP1

GO Terms for genes affiliated with Corneal Disease

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Cellular components related to Corneal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1TGFBI, TGFB2, AKR1B1, IL1A, LCAT, NGF
2extracellular regionGO:0055766.6GSN, TFF3, NGF, TIMP1, TGFBI, TGFB2

Biological processes related to Corneal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.1MMP1, TGFB2, TGFBI, TIMP1
2response to peptide hormoneGO:0434348.8TIMP1, NGF, TFF3

Products for genes affiliated with Corneal Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Corneal Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet