MCID: CRN024
MIFTS: 52

Corneal Disease malady

Eye diseases category

Summaries for Corneal Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your cornea is the outermost layer of your eye. it is clear and shaped like a dome. the cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. it also helps your eye to focus. if you wear contact lenses, they float on top of your corneas. problems with the cornea include refractive errors allergies infections injuries dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material treatments of corneal disorders include medicines, corneal transplantation, and corneal laser surgery. nih national eye institute

MalaCards: Corneal Disease, also known as corneal diseases, is related to herpes simplex and keratitis. An important gene associated with Corneal Disease is CHST6 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6), and among its related pathways are NF-KappaB Family Pathway and Akt Signaling. The drug deferoxamine mesylate and the compounds rantes and estrogen have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and heart, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:63 The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.... more...

Aliases & Classifications for Corneal Disease

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Sources:
30LifeMap Discovery™, 8Disease Ontology, 44Novoseek, 60UMLS, 33MedlinePlus, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal disease 30 8
corneal diseases 44 60
corneal disorders 33


External Ids:

Disease Ontology8 DOID:10124
NCIt39 C26731
ICD9CM27 371.9
MeSH34 D003316
ICD1025 H17.9

Related Diseases for Corneal Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Corneal Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex30.4TLR3, GJB2
2keratitis30.3GJB2
3cataract30.3TGFB2, TGFBI, GJB2, AKR1B1
4glaucoma30.3TGFB2, MMP1, AKR1B1
5bullous keratopathy30.1TGFB2, IL1A
6recurrent corneal erosion30.0TGFBI, KRT12
7rheumatoid arthritis29.9MMP1, IL1A, TLR3, TIMP1
8arthritis29.9TIMP1, TLR3, IL1A, MMP1, SP1
9lens disease10.2
10limbal stem cell deficiency10.2
11conjunctival disease10.2
12eye disease10.1
13keratoconjunctivitis10.1
14keratopathy10.1
15keratoconjunctivitis sicca10.0
16acute myocardial infarction10.0LCAT
17stevens-johnson syndrome10.0KRT3
18primary open angle glaucoma10.0TGFB2
19neuroblastoma10.0NGF
20coronary heart disease10.0LCAT
21allergic rhinitis10.0NGF
22retinal detachment10.0TGFB2
23proliferative vitreoretinopathy10.0TGFB2
24inflammatory bowel disease10.0TFF3
25meesmann corneal dystrophy10.0KRT12, KRT3
26skin disease10.0IL1A
27keratosis10.0GJB2
28sensorineural hearing loss10.0GJB2
29diabetic retinopathy10.0AKR1B1, TGFB2
30familial mediterranean fever10.0GSN
31lattice corneal dystrophy10.0GSN, TGFBI
32ischemia10.0TGFB2, AKR1B1
33polyneuropathy10.0AKR1B1, GSN
34tuberculosis10.0SP1
35gastric ulcer10.0TFF3
36cholesteatoma10.0IL1A
37lattice corneal dystrophy type 110.0TGFBI, GSN
38amyloidosis corneal10.0TGFBI, GSN
39sarcoidosis10.0TGFB2, IL1A
40cataract 4, multiple types10.0TGFB2, AKR1B1
41biliary atresia10.0TIMP1
42dementia10.0SP1, NGF
43chondrosarcoma10.0MMP1
44uveitis10.0TGFB2, IL1A
45diabetic autonomic neuropathy10.0NGF, AKR1B1
46myopathy10.0NGF, GSN
47cystic fibrosis10.0GSN, GJB2
48diabetes mellitus10.0NGF, AKR1B1, LCAT
49myocardial infarction10.0SP1, AKR1B1, LCAT
50hepatitis10.0TLR3

Graphical network of the top 20 diseases related to Corneal Disease:



Diseases related to corneal disease

Clinical Features for Corneal Disease

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Drugs & Therapeutics for Corneal Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Corneal Disease

Drug clinical trials:

Search ClinicalTrials for Corneal Disease

Search NIH Clinical Center for Corneal Disease

Search CenterWatch for Corneal Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Corneal Disease

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Anatomical Context for Corneal Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Corneal Disease:

32
Eye, Endothelial, Heart, Thyroid, T cells, Testes, Skin, Spleen, Kidney, Liver, Small intestine, Colon

Animal Models for Corneal Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Corneal Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.0TGFB2, GSN, SP1, CHRNG
2MP:00053918.1LCAT, AKR1B1, NGF, GJB2, KRT12, SP1
3MP:00053856.7NGF, TLR3, LCAT, TIMP1, IL1A, GJB2
4MP:00053876.4TIMP1, TLR3, TFF3, IL1A, GJB2, PTGER3
5MP:00107686.3CHRNG, AKR1B1, TLR3, TIMP1, NGF, GJB2
6MP:00053766.1TGFBI, LCAT, TLR3, TFF3, AKR1B1, CHRNG

Publications for Corneal Disease

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Sources:
50PubMed
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Articles related to Corneal Disease:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Mosaic Chromosome 18q Partial Deletion Syndrome with Bilateral Full-thickness Corneal Disease: Surgical Intervention and Histopathology. (24024746)
2013
2
Cataract surgery in patients with corneal disease. (23197265)
2013
3
Effect of topical 0.05% cyclosporine A on corneal endothelium in patients with dry eye disease. (23991381)
2013
4
Metaherpetic corneal disease in a dog associated with partial limbal stem cell deficiency and neurotrophic keratitis. (22958361)
2013
5
Correlation of clinical and pathologic diagnoses of corneal disease in penetrating keratoplasties in Vancouver: a 10-year review. (22333843)
2012
6
Collagen cross-linking: a new treatment paradigm in corneal disease - a review. (20398104)
2010
7
A new corneal disease with recurrent erosive episodes and autosomal-dominant inheritance. (18778339)
2008
8
Corneal striae in thyroid eye disease. (17277745)
2007
9
Effects of CXCR3 signaling on development of fatal encephalitis and corneal and periocular skin disease in HSV-infected mice are mouse-strain dependent. (17724202)
2007
10
Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease. (17007837)
2007
11
Mutation of the phospholipase catalytic domain of the Pseudomonas aeruginosa cytotoxin ExoU abolishes colonization promoting activity and reduces corneal disease severity. (17905228)
2007
12
Elevated levels of human alpha -defensin in tears of patients with allergic conjunctival disease complicated by corneal lesions: detection by SELDI ProteinChip system and quantification. (16123017)
2005
13
Genetics of corneal disease for the ocular surface clinician. (17131020)
2005
14
Confocal microscopy and corneal sensitivity in a patient with corneal manifestations of Tangier disease. (15502486)
2004
15
Two patients with severe corneal disease in KID syndrome. (14700667)
2004
16
Evidence of oxidative stress in human corneal diseases. (11850437)
2002
17
Sterile corneal melting and necrotizing scleritis after cataract surgery in patients with rheumatoid arthritis and collagen vascular disease. (12759840)
2002
18
Varicella-zoster virus: mechanisms of pathogenicity and corneal disease. (12064084)
2002
19
Cultured corneal epithelia for ocular surface disease. (10703147)
1999
20
Corneoscleral transplantation for end stage corneal disease. (9924332)
1998
21
Intermediate filament expression by normal and diseased human corneal epithelium. (9416689)
1997
22
Surgical management of corneal disease. (9474299)
1997
23
Changing patterns of corneal disease and associated vision loss at a rural African hospital following a training programme for traditional healers. (8949711)
1996
24
Compound heterozygosity for a structural apolipoprotein A-I variant, apo A-I(L141R)Pisa, and an apolipoprotein A-I null allele in patients with absence of HDL cholesterol, corneal opacifications, and coronary heart disease. (8840853)
1996
25
Management of coexisting corneal disease and glaucoma by combined penetrating keratoplasty and trabeculectomy with mitomycin-C. (8938797)
1996
26
Circulating cornea-specific antibodies in corneal disease and cornea transplantation. (8157180)
1994
27
Endogenous hyaluronan in corneal disease. (8188472)
1994
28
Corneal opacity in LCAT disease. (1468226)
1992
29
Metabolic analysis of the diseased human corneal endothelium]. (1502980)
1992
30
Compensatory epithelial hyperplasia in human corneal disease. (1484663)
1992
31
Use of corticosteroids in combination with antimicrobial drugs in the treatment of infectious corneal disease. (1866135)
1991
32
Corneal changes in Tay-Sachs disease. (2191759)
1990
33
The ophthalmic nurse role in the prevention of corneal disease. (2142714)
1990
34
Juxtapapillary choroidal neovascular membrane in a patient with Paget's disease and lattice corneal dystrophy. (2477432)
1989
35
Corneal disease in rural Transkei. (2727827)
1989
36
Botulinum toxin A-induced protective ptosis in corneal disease. (3050691)
1988
37
Elevation of tear fluid plasmin in corneal disease. (2973722)
1988
38
Herpes simplex and recurrent corneal disease. (6327557)
1984
39
Neglected lid deformities causing progressive corneal disease. Surgical correction of entropion, trichiasis, marginal keratinization, and functional lid shortening. (1087767)
1976
40
Topically applied steroids in corneal disease. V. Dexamethasone alcohol. (4416662)
1974
41
A simple scheme for documenting corneal disease. (4127939)
1973
42
Corticosteroid therapy in corneal disease. I. (4361430)
1973
43
Hydrophilic contact lenses in corneal disease. IV. Penetrating corneal wounds. (5085201)
1972
44
Corneal ulcer due to Pseudomonas aeruginosa. A comparison of the disease in California and El Salvador. (4995262)
1971
45
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
46
Corneal disease. (4909448)
1970
47
Cataract complicated by glaucoma or by corneal disease. (5499907)
1970
48
NEW DEVELOPMENTS IN THE TREATMENT OF CORNEAL DISEASE. (14341367)
1965
49
MACULAR CORNEAL DYSTROPHY. AN INHERITED ACID MUCOPOLYSACCHARIDE STORAGE DISEASE OF THE CORNEAL FIBROBLAST. (14217673)
1964
50
Conjunctival flaps in the treatment of corneal disease with reference to a new technique of application. (13582332)
1958

Genetic Variations for Corneal Disease

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Expression for genes affiliated with Corneal Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Disease

Search GEO for disease gene expression data for Corneal Disease.

Pathways for genes affiliated with Corneal Disease

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51QIAGEN
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Pathways related to Corneal Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.9TGFB2, IL1A, TLR3, TIMP1
2
Hide members
8.3TGFB2, SP1, IL1A, TLR3, TIMP1

Compounds for genes affiliated with Corneal Disease

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Corneal Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1rantes4410.5IL1A
2estrogen4410.5LCAT
3glutamate4410.3LCAT, GSN
4norepinephrine44 11 2412.3MMP1
5butyrate4410.3LCAT, GSN
6sodium dodecylsulfate4410.2IL1A, LCAT
7epinephrine44 11 2412.0NGF, AKR1B1, IL1A
81-(5-isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride449.8IL1A, TIMP1
9uva 1449.7TIMP1, IL1A, MMP1
10cyclosporin a44 28 5911.7TGFB2, MMP1, NGF, AKR1B1
11guanidine44 11 2411.5TIMP1, LCAT, NGF
12forskolin44 49 1111.5GJB2, SP1
13vitamin d449.5GSN, NGF, SP1, TGFB2
14pge1449.4MMP1, IL1A, LCAT, PTGER3
15ascorbic acid44 2410.3LCAT, TGFB2, AKR1B1, IL1A, MMP1
16glycosaminoglycan449.3IL1A, TGFB2, TIMP1, MMP1
17dihydrotestosterone44 28 11 2412.2SP1, NGF, AKR1B1, TGFB2, GSN
18pdtc449.2SP1, IL1A, MMP1, NGF
19tetracycline44 1110.2SP1, MMP1, IL1A, NGF
20vitamin a44 11 2411.2TIMP1, TGFB2, LCAT, IL1A, MMP1
21azathioprine44 49 2 1112.1SP1, GSN, TIMP1, NGF
22paclitaxel44 49 1111.1GSN, TIMP1, SP1, IL1A
23herbimycin a44 5910.1IL1A, TIMP1, NGF, MMP1
24matrigel449.0TIMP1, NGF, MMP1, GJB2, TGFB2
25hyaluronic acid44 249.9TGFB2, TIMP1, IL1A, MMP1
26prostaglandin448.9IL1A, MMP1, PTGER3, TIMP1, TGFB2
27tgf beta1448.9SP1, TIMP1, MMP1, TGFB2
28curcumin448.8TIMP1, AKR1B1, IL1A, MMP1, SP1
29n acetylcysteine448.8TGFB2, SP1, MMP1, AKR1B1, TIMP1
30dexamethasone44 49 28 1111.8TGFB2, SP1, TLR3, LCAT, TIMP1
3112-o-tetradecanoylphorbol 13-acetate448.7TIMP1, NGF, IL1A, MMP1, SP1
32sb 20358044 599.7IL1A, NGF, SP1, TIMP1, MMP1
33prostacyclin448.7NGF, IL1A, PTGER3, SP1, TIMP1
34aspirin44 49 28 2411.6TFF3, TIMP1, AKR1B1, NGF, MMP1
35calcitriol44 59 11 2411.5TGFB2, IL1A, NGF, TIMP1, MMP1, SP1
36genistein44 28 59 2 11 2413.3TIMP1, AKR1B1, NGF, IL1A, MMP1, SP1
37testosterone44 59 11 2411.3NGF, AKR1B1, LCAT, IL1A, MMP1, SP1
38arginine448.2IL1A, KRT12, KRT3, NGF, AKR1B1, TIMP1
39glutamine448.2TGFBI, TGFB2, NGF, IL1A, TIMP1, LCAT
40actinomycin d448.1IL1A, TIMP1, TFF3, SP1, NGF, AKR1B1
41serine448.1LCAT, TIMP1, SP1, MMP1, IL1A, AKR1B1
42pd 98,059448.0SP1, MMP1, NGF, TIMP1, TFF3
43paraffin447.8TIMP1, MMP1, GJB2, TGFB2, TFF3
44h2o2447.8TIMP1, TFF3, AKR1B1, IL1A, MMP1, SP1
45progesterone44 59 28 11 2411.7TGFB2, PTGER3, MMP1, GJB2, TIMP1, TFF3
46phosphatidylinositol447.6TFF3, TLR3, TIMP1, GSN, NGF, SP1
47indomethacin44 59 28 1110.6NGF, IL1A, MMP1, PTGER3, TGFB2, TFF3
48vegf447.5AKR1B1, TFF3, NGF, IL1A, MMP1, SP1
49retinoic acid44 248.4SP1, GSN, TGFB2, MMP1, GJB2, IL1A
50cysteine447.0SP1, TIMP1, LCAT, TGFB2, TGFBI, GSN

GO Terms for genes affiliated with Corneal Disease

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Sources:
16Gene Ontology
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Cellular components related to Corneal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6AKR1B1, NGF, IL1A, GSN, TGFBI, TGFB2
2extracellular regionGO:0055766.8TGFB2, TIMP1, LCAT, TFF3, NGF, IL1A

Biological processes related to Corneal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.1TGFB2, TGFBI, MMP1, TIMP1
2response to peptide hormone stimulusGO:0434348.6NGF, TFF3, TIMP1

Products for genes affiliated with Corneal Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corneal Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet