MCID: CRN024
MIFTS: 52

Corneal Disease malady

Eye diseases category
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Summaries for Corneal Disease

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Your cornea is the outermost layer of your eye. it is clear and shaped like a dome. the cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. it also helps your eye to focus. if you wear contact lenses, they float on top of your corneas. problems with the cornea include refractive errors allergies infections injuries dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material treatments of corneal disorders include medicines, corneal transplantation, and corneal laser surgery. nih national eye institute

MalaCards: Corneal Disease, also known as corneal diseases, is related to cataract and glaucoma. An important gene associated with Corneal Disease is KRT12 (keratin 12), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Colorectal Cancer Metastasis. The drug deferoxamine mesylate and the compounds uva 1 and glycosaminoglycan have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes, and related mouse phenotypes are respiratory system and tumorigenesis.

Wikipedia:65 The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.... more...

Aliases & Classifications for Corneal Disease

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Sources:
31LifeMap Discovery™, 8Disease Ontology, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal disease 31 8
corneal diseases 45 62
corneal disorders 34


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Disease Ontology8 DOID:10124
MeSH35 D003316
ICD9CM27 371.9
NCIt40 C26731
ICD1025 H17.9

Related Diseases for Corneal Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Corneal Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1cataract30.3TGFBI, GJB2, AKR1B1, TGFB2
2glaucoma30.3AKR1B1, TGFB2, MMP1
3bullous keratopathy30.2IL1A, TGFB2
4arthritis30.0TIMP1, IL1A
5herpes simplex10.3
6keratitis10.2
7limbal stem cell deficiency10.1
8meesmann corneal dystrophy10.1KRT12, KRT3
9oral submucous fibrosis10.1TIMP1, MMP1
10polyneuropathy10.1AKR1B1, GSN
11recurrent corneal erosion10.1TGFBI, KRT12
12lattice corneal dystrophy type 110.1TGFBI, GSN
13periodontitis10.1IL1A
14amyloidosis corneal10.1TGFBI, GSN
15lattice corneal dystrophy10.1GSN, TGFBI
16cataract 4, multiple types10.1AKR1B1, TGFB2
17aggressive periodontitis10.1MMP1, IL1A
18hypertrophic scars10.1MMP1, TIMP1
19abdominal aortic aneurysm10.1MMP1, TIMP1
20open-angle glaucoma10.1TGFB2, MMP1
21middle ear cholesteatoma10.1IL1A, MMP1
22oral lichen planus10.1MMP1, IL1A
23keratoconjunctivitis10.1
24keratopathy10.1
25blindness10.1
26hepatitis c10.1TIMP1, TLR3, MMP1
27diabetic polyneuropathy10.1AKR1B1, NGF
28glomerulosclerosis10.1AKR1B1, TIMP1, LCAT
29diabetic autonomic neuropathy10.1AKR1B1, NGF
30psoriatic arthritis10.0IL1A, MMP1
31diabetic neuropathy10.0NGF, AKR1B1
32pulpitis10.0TIMP1, MMP1, IL1A
33gingival overgrowth10.0TIMP1, IL1A, MMP1
34gingivitis10.0MMP1, IL1A, TIMP1
35proliferative vitreoretinopathy10.0TIMP1, TGFB2
36pulmonary fibrosis10.0TIMP1, MMP1, TGFB2
37synovitis10.0IL1A, MMP1, TIMP1
38autonomic neuropathy10.0NGF, AKR1B1
39periodontal disease10.0TIMP1, IL1A, MMP1
40amyloid tumor10.0GSN, KRT12, TGFBI, KRT3
41eye disease10.0NGF
42endometriosis10.0MMP1, TIMP1, IL1A
43renal fibrosis10.0TIMP1, TGFB2
44skin disease10.0IL1A, MMP1, GJB2
45breast cancer10.0SP1, GSN, GJB2
46keloids10.0MMP1, SP1, TGFB2
47sensory peripheral neuropathy10.0AKR1B1, NGF
48ulcerative colitis10.0IL1A, MMP1, TLR3, TFF3
49conjunctivochalasis10.0MMP1, TIMP1, PTGER3
50corneal dystrophy10.0KRT3, TGFBI, CHST6, GSN, KRT12

Graphical network of the top 20 diseases related to Corneal Disease:



Diseases related to corneal disease

Symptoms for Corneal Disease

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Drugs & Therapeutics for Corneal Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Corneal Disease

Search NIH Clinical Center for Corneal Disease

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Corneal Disease

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Anatomical Context for Corneal Disease

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33MalaCards
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MalaCards organs/tissues related to Corneal Disease:

33
Eye, T cells, Testes, Colon, Small intestine

Animal Models for Corneal Disease or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Corneal Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7SP1, TLR3, TIMP1, TGFB2, GSN
2MP:00020068.5TIMP1, TGFBI, MMP1, IL1A, TLR3
3MP:00053918.0LCAT, SP1, GJB2, NGF, TGFB2, KRT12
4MP:00053977.4TIMP1, TGFBI, TGFB2, IL1A, LCAT, GSN
5MP:00053876.5TFF3, TLR3, TIMP1, GJB2, TGFB2, MMP1
6MP:00053856.4NGF, PTGER3, TIMP1, TGFB2, IL1A, LCAT
7MP:00107686.4GSN, AKR1B1, TGFB2, TGFBI, TIMP1, PTGER3
8MP:00053764.9SP1, TGFBI, GJB2, GSN, LCAT, IL1A

Publications for Corneal Disease

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Sources:
52PubMed
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Articles related to Corneal Disease:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
Mosaic Chromosome 18q Partial Deletion Syndrome with Bilateral Full-thickness Corneal Disease: Surgical Intervention and Histopathology. (24024746)
2013
2
Cataract surgery in patients with corneal disease. (23197265)
2013
3
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice. (22647700)
2012
4
Pilot Study for OCT Guided Design and Fit of a Prosthetic Device for Treatment of Corneal Disease. (23316338)
2012
5
Correlation of clinical and pathologic diagnoses of corneal disease in penetrating keratoplasties in Vancouver: a 10-year review. (22333843)
2012
6
Histopathology and treatment of corneal disease in keratitis, ichthyosis, and deafness (KID) syndrome. (19590522)
2010
7
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. (20007286)
2010
8
Collagen cross-linking: a new treatment paradigm in corneal disease - a review. (20398104)
2010
9
Disruption of CFTR-dependent lipid rafts reduces bacterial levels and corneal disease in a murine model of Pseudomonas aeruginosa keratitis. (18326723)
2008
10
CD8(+) T cells control corneal disease following ocular infection with herpes simplex virus type 1. (15218191)
2004
11
Laser applications for corneal disease. (14604095)
2003
12
Applications of contact lens devices in the management of corneal disease. (14631391)
2003
13
Prospects for gene therapy in corneal disease. (14631395)
2003
14
Corneal disease in patients with chronic renal insufficiency undergoing hemodialysis. (11588419)
2001
15
Iatrogenic limbal stem cell deficiency: when glaucoma management contributes to corneal disease. (11740212)
2001
16
Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness). (11123754)
2000
17
Acremonium keratitis in a patient with herpetic neurotrophic corneal disease. (10726803)
2000
18
Management of coincident corneal disease and cataract. (10387322)
1999
19
An analysis of 1,001 blinding patients with corneal disease in 1960-1989. (12580077)
1998
20
Corneoscleral transplantation for end stage corneal disease. (9924332)
1998
21
Detection of interleukin-1 beta in the tear fluid of patients with corneal disease with or without conjunctival involvement. (9152805)
1997
22
High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation. (8627763)
1996
23
Changing patterns of corneal disease and associated vision loss at a rural African hospital following a training programme for traditional healers. (8949711)
1996
24
Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis. (8849537)
1995
25
Traditional eye medicine use among patients with corneal disease in rural Malawi. (7848973)
1994
26
Circulating cornea-specific antibodies in corneal disease and cornea transplantation. (8157180)
1994
27
Clinical and diagnostic use of in vivo confocal microscopy in patients with corneal disease. (8414403)
1993
28
Anterior corneal disease of epidermolysis bullosa simplex. (8470983)
1993
29
Compensatory epithelial hyperplasia in human corneal disease. (1484663)
1992
30
Endogenously produced interferon alpha protects mice from herpes simplex virus type 1 corneal disease. (1649898)
1991
31
Corneal disease in Africa. (1782163)
1991
32
Herpes simplex virus--induced destructive corneal disease. (2559859)
1989
33
Botulinum toxin A-induced protective ptosis in corneal disease. (3050691)
1988
34
Ophthalmology: viral corneal disease. (18749959)
1986
35
Diabetic corneal disease. (3155119)
1986
36
The prevalence of corneal disease in the coloured community of a Karoo town. (3992399)
1985
37
A new bandage lens for treatment of corneal disease: Softcon XT. (6509765)
1984
38
Inflammatory Terrien's marginal corneal disease. (7270631)
1981
39
Primary corneal disease in the dog and cat. (6251593)
1980
40
Destructive corneal disease in the connective tissue disorders. Comparison with an experimental animal model. (38536)
1978
41
Use of anti-inflammatory agents in destructive corneal disease. (382459)
1978
42
Neglected lid deformities causing progressive corneal disease. Surgical correction of entropion, trichiasis, marginal keratinization, and functional lid shortening. (1087767)
1976
43
The Bausch and Lomb "T" lens in the treatment of corneal disease. (1070889)
1976
44
The use of therapeutic soft contact lenses in corneal disease. (1152538)
1975
45
Complications in use of soft contact lenses in corneal disease. (4746087)
1973
46
A simple scheme for documenting corneal disease. (4127939)
1973
47
Topically applied steroids in corneal disease. II. The role of drug vehicle in stromal absorption of dexamethasone. (4634795)
1972
48
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
49
Diagnosing corneal disease. (5726393)
1968
50
Corneal disease. (5903646)
1966

Variations for Corneal Disease

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Expression for genes affiliated with Corneal Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Disease

Search GEO for disease gene expression data for Corneal Disease.

Pathways for genes affiliated with Corneal Disease

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Sources:
50PathCards, 60Thomson Reuters, 53QIAGEN, 30KEGG, 54R&D Systems, 38NCBI BioSystems Database
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Pathways related to Corneal Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MMP1, TIMP1
29.5TLR3, TGFB2, MMP1
39.3MMP1, IL1A, TGFB2
4
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.2TLR3, IL1A, SP1
5
Show member pathways
9.1IL1A, TGFB2, TIMP1, TLR3
69.0SP1, NGF, IL1A
7
Show member pathways
8.6SP1, TLR3, TIMP1, TGFB2, IL1A

Compounds for genes affiliated with Corneal Disease

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 3BitterDB, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Corneal Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1uva 1459.9IL1A, MMP1, TIMP1
2glycosaminoglycan459.2IL1A, MMP1, TGFB2, TIMP1
3sodium dodecylsulfate459.2MMP1, IL1A, LCAT, GSN
4rantes459.2TLR3, TIMP1, TGFB2, MMP1, IL1A
5matrigel459.1NGF, TIMP1, TGFB2, MMP1, GJB2
6vitamin a45 24 1111.1TIMP1, TGFB2, MMP1, IL1A, LCAT
7pdtc459.1IL1A, MMP1, NGF, SP1
8azathioprine45 3 51 1112.0GSN, TIMP1, NGF, SP1
9curcumin459.0SP1, TIMP1, MMP1, AKR1B1, IL1A
10tetracycline45 1110.0SP1, NGF, MMP1, IL1A
11n acetylcysteine459.0SP1, TIMP1, TGFB2, MMP1, AKR1B1
12ascorbic acid45 2410.0TGFB2, MMP1, AKR1B1, IL1A, LCAT
13egcg458.9SP1, TIMP1, TGFB2, MMP1, IL1A
14pge1458.9PTGER3, MMP1, IL1A, LCAT
15aspirin45 51 29 2411.8TFF3, NGF, TIMP1, MMP1, AKR1B1
16paclitaxel45 51 1110.8SP1, TIMP1, MMP1, IL1A, GSN
17dihydrotestosterone45 29 24 1111.8SP1, NGF, TGFB2, AKR1B1, GSN
18norepinephrine45 24 1110.8NGF, TIMP1, MMP1, AKR1B1, IL1A
19epinephrine45 24 1110.7SP1, NGF, MMP1, AKR1B1, IL1A
2012-o-tetradecanoylphorbol 13-acetate458.7IL1A, MMP1, TIMP1, NGF, SP1
21sb 20358045 619.7SP1, NGF, TIMP1, MMP1, IL1A
22tgf beta1458.7SP1, TIMP1, TGFB2, MMP1
23butyrate458.6SP1, TFF3, TIMP1, LCAT, GSN
24prostaglandin458.6PTGER3, TIMP1, TGFB2, MMP1, IL1A
25cyclosporin a45 29 6110.6NGF, TIMP1, TGFB2, MMP1, AKR1B1, IL1A
26paraffin458.6GJB2, MMP1, TGFB2, TIMP1, TFF3
27calcitriol45 61 24 1111.4SP1, NGF, TIMP1, TGFB2, MMP1, IL1A
28vitamin d458.4SP1, NGF, TIMP1, TGFB2, IL1A, GSN
29forskolin45 51 1110.3GJB2, IL1A, TGFB2, NGF, SP1
30h2o2458.3SP1, TFF3, TIMP1, MMP1, AKR1B1, IL1A
31prostacyclin458.3IL1A, TIMP1, PTGER3, NGF, SP1
32pd 98,059458.3SP1, TFF3, NGF, TIMP1, MMP1
33actinomycin d458.2SP1, TFF3, NGF, TIMP1, AKR1B1, IL1A
34genistein45 29 61 3 24 1113.1SP1, NGF, TIMP1, TGFB2, MMP1, AKR1B1
35cycloheximide458.1SP1, NGF, TIMP1, TGFB2, MMP1, AKR1B1
36estrogen458.0SP1, TFF3, TIMP1, TGFB2, MMP1, AKR1B1
37arginine458.0SP1, NGF, TIMP1, TGFBI, AKR1B1, IL1A
38glutamate458.0SP1, NGF, TIMP1, TGFB2, IL1A, LCAT
39phosphatidylinositol457.9SP1, TFF3, TLR3, NGF, TIMP1, TGFB2
40dexamethasone45 51 29 1110.8SP1, TLR3, NGF, TIMP1, TGFB2, MMP1
41progesterone45 29 61 24 1111.8TFF3, PTGER3, TIMP1, TGFB2, MMP1, IL1A
42testosterone45 61 24 1110.8SP1, NGF, TGFB2, MMP1, AKR1B1, IL1A
43glutamine457.7SP1, NGF, TIMP1, TGFBI, TGFB2, AKR1B1
44retinoic acid45 248.6SP1, TLR3, NGF, TIMP1, TGFB2, MMP1
45vegf457.5SP1, TFF3, NGF, TIMP1, TGFB2, MMP1
46indomethacin45 29 61 1110.2IL1A, TFF3, NGF, PTGER3, TIMP1, TGFB2
47pge2457.2SP1, TFF3, PTGER3, TIMP1, TGFB2, MMP1
48cysteine457.0SP1, TFF3, NGF, TIMP1, TGFBI, TGFB2
49serine456.9SP1, TLR3, NGF, TIMP1, TGFBI, TGFB2
50tyrosine456.8SP1, TFF3, TLR3, NGF, PTGER3, TIMP1

GO Terms for genes affiliated with Corneal Disease

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Sources:
16Gene Ontology
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Cellular components related to Corneal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1TGFBI, TGFB2, AKR1B1, IL1A, LCAT, NGF
2extracellular regionGO:0055766.6GSN, TFF3, NGF, TIMP1, TGFBI, TGFB2

Biological processes related to Corneal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.1MMP1, TGFB2, TGFBI, TIMP1
2response to peptide hormoneGO:0434348.8TIMP1, NGF, TFF3

Products for genes affiliated with Corneal Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corneal Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet