Corneal Disease malady

MedlinePlus: Your cornea is the outermost layer of your eye. it is clear and shaped like a dome. the cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. it also helps your eye to focus. if you wear contact lenses, they float on top of your corneas. problems with the cornea include refractive errors allergies infections injuries dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material treatments of corneal disorders include medicines, corneal transplantation and corneal laser surgery. nih national eye institute²³

MalaCards: Corneal Disease, also known as corneal disorders, is related to arthritis and meesmann corneal dystrophy. An important gene associated with Corneal Disease is KRT12 (keratin 12), and among its related pathways is Rheumatoid arthritis. The drug deferoxamine mesylate and the compounds vitamin a and hyaluronic acid have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and homeostasis/metabolism.

Wikipedia: The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber....⁴⁴ more...

Aliases & Descriptions:

corneal disease 6 corneal disorders 17 23

corneal diseases 32 43

Diseases related to corneal disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 155)

id	Related Disease	Score	Top Affiliating Genes
1	arthritis	24.1	TGFBI, TGFB2, TIMP1, NGF, SP1, IL1A
2	meesmann corneal dystrophy	13.5	KRT12, KRT3
3	recurrent corneal erosion	13.5	TGFBI, KRT12
4	lattice corneal dystrophy type 1	13.4	GSN, TGFBI
5	mongolian spot	13.4	KRT12, CHST6
6	amyloidosis corneal	13.4	TGFBI, GSN
7	lattice corneal dystrophy	13.3	TGFBI, GSN, CHST6
8	diabetic autonomic neuropathy	13.2	NGF, AKR1B1
9	keratoconjunctivitis sicca	13.2	NGF, IL1A
10	amyloid tumor	13.0	TGFBI, KRT3, KRT12, GSN
11	diabetic neuropathy	13.0	AKR1B1, NGF
12	hereditary hemorrhagic telangiectasia	13.0	SP1, TGFB2, TGFBI
13	autosomal dominant disease	12.9	KRT3, GJB2, KRT12
14	t cell deficiency	12.9	IL1A, NGF, KRT12, KRT3
15	appendicitis	12.8	LCAT, IL1A, TIMP1
16	aggressive periodontitis	12.8	IL1A, MMP1
17	type 2 diabetes mellitus	12.8	TGFBI, NGF, AKR1B1, LCAT
18	bullous keratopathy	12.8	TGFB2, TIMP1, IL1A
19	retinal detachment	12.7	TGFBI, TGFB2, TIMP1
20	proliferative vitreoretinopathy	12.7	TIMP1, TGFB2, TGFBI
21	inclusion body myositis	12.7	IL1A, NGF, TGFB2
22	cerebral primitive neuroectodermal tumor	12.6	IL1A, NGF, TGFB2
23	middle ear cholesteatoma	12.6	IL1A, MMP1
24	polyneuropathy	12.6	TIMP1, NGF, AKR1B1, GSN
25	biliary atresia	12.6	IL1A, TIMP1, TGFB2
26	ependymoma	12.5	TGFB2, NGF, IL1A
27	osteoarthritis susceptibility 6	12.5	TIMP1, MMP1
28	corneal dystrophy	12.5	TGFBI, KRT3, KRT12, GSN, LCAT, CHST6
29	conjunctivochalasis	12.5	MMP1, TIMP1
30	keratitis	12.5	KRT3, NGF, GJB2, IL1A
31	graft versus host disease	12.5	TFF3, TGFBI, TGFB2, IL1A
32	cork-handlers' disease	12.5	MMP1, IL1A, TGFBI
33	uveitis	12.4	IL1A, AKR1B1, TIMP1, TGFB2
34	peripheral neuropathy	12.4	NGF, GJB2, AKR1B1, GSN
35	proliferative diabetic retinopathy	12.4	TGFB2, TIMP1, SP1, AKR1B1
36	vascular dementia	12.4	NGF, IL1A, MMP1
37	collagenous colitis	12.4	TIMP1, MMP1
38	sensorineural hearing loss	12.4	NGF, GJB2, IL1A, GSN
39	pulpitis	12.4	TIMP1, IL1A, MMP1
40	periodontitis	12.3	MMP1, IL1A, TIMP1
41	keratopathy	12.3	TGFB2, TIMP1, KRT12, AKR1B1, IL1A
42	bartter disease	12.3	TGFB2, NGF, SP1, AKR1B1, GSN
43	vernal keratoconjunctivitis	12.3	TIMP1, NGF, MMP1
44	cerebral malaria	12.3	TGFB2, IL1A, MMP1
45	bronchiolitis	12.3	TGFB2, TIMP1, NGF, IL1A
46	periodontal disease	12.3	MMP1, IL1A, TIMP1
47	cytomegalovirus infection	12.2	TGFB2, NGF, SP1, GJB2
48	aneurysm disease	12.2	MMP1, TIMP1
49	adenomyosis	12.2	TIMP1, NGF, MMP1
50	familial mediterranean fever	12.2	MMP1, GSN, TIMP1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 deferoxamine mesylate

MGI Mouse Phenotypes related to corneal disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	vision/eye phenotype	MP:0005391	8.0	KRT12, NGF, SP1, GJB2, AKR1B1, LCAT
2	homeostasis/metabolism phenotype	MP:0005376	5.6	LCAT, CHRNG, TFF3, TGFBI, TGFB2, TIMP1

Articles related to corneal disease:

id	Title	Authors	Year	Affiliating Genes
1	Two patients with severe corneal disease in KID syndrome. (14700667)	Sonoda S.... Sakamoto T.	2004	GJB2
2	Distribution of TFF peptides in corneal disease and pterygium. (15177877)	Steven P.... Paulsen F.	2004	TFF3
3	Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis. (8849537)	Riley G.P.... Hazleman B.L.	1995	MMP1, TIMP1

Genes related to corneal disease according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	KRT12	keratin 12	11.0
2	KRT3	keratin 3	11.0
3	CHST6	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	11.0
4	TGFBI	transforming growth factor, beta-induced, 68kDa	11.0
5	LCAT	lecithin-cholesterol acyltransferase	11.0
6	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	11.0
7	GSN	gelsolin	11.0
8	IL1A	interleukin 1, alpha	11.0
9	SP1	Sp1 transcription factor	11.0
10	NGF	nerve growth factor (beta polypeptide)	11.0
11	TGFB2	transforming growth factor, beta 2	11.0
12	TFF3	trefoil factor 3 (intestinal)	11.0	Publications
13	CHRNG	cholinergic receptor, nicotinic, gamma (muscle)	11.0
14	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications
15	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
16	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications

Pathways related to corneal disease according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Rheumatoid arthritis20	9.2	MMP1, IL1A, TGFB2

Compounds related to corneal disease according to GeneDecks:

(show top 50)    (show all 83)

id	Compound	Score	Top Affiliating Genes
1	vitamin a32 9 18 9	13.2	TGFB2, LCAT
2	hyaluronic acid32 18	11.0	MMP1
3	progesterone32 42 9 18 9	13.7	GJB2, TGFB2
4	h2o232	9.6	AKR1B1, SP1, TFF3
5	arecoline32 9 9	11.6	IL1A, TIMP1
6	1-(5-isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride32	9.5	IL1A, TIMP1
7	sodium dodecylsulfate32	9.4	LCAT, MMP1, GSN, IL1A
8	pdtc32	9.3	MMP1, IL1A, SP1, NGF
9	tetracycline32 9 9	11.3	NGF, SP1, IL1A, MMP1
10	uva 132	9.2	MMP1, IL1A, TIMP1
11	dihydrotestosterone32 9 18 9	12.2	TGFB2, NGF, SP1, AKR1B1, GSN
12	guanidine32 9 18 9	12.1	LCAT, NGF, TIMP1
13	sorbinil32 9 9	11.1	AKR1B1, TIMP1
14	ascorbic acid32 18	10.0	TGFB2, AKR1B1, IL1A, MMP1, LCAT
15	epinephrine32 9 18 9	12.0	MMP1, IL1A, AKR1B1, SP1, NGF
16	azathioprine32 34 9 9	12.0	TIMP1, NGF, SP1, GSN
17	tgf beta132	9.0	TIMP1, SP1, MMP1
18	glutamate32	8.7	TGFB2, TIMP1, SP1, GSN, LCAT
19	prostacyclin32	8.6	IL1A, SP1, NGF, TIMP1
20	butyrate32	8.6	TFF3, TIMP1, SP1, GSN, LCAT
21	herbimycin a32 42	9.6	MMP1, IL1A, NGF, TIMP1
22	curcumin32	8.6	TIMP1, SP1, AKR1B1, IL1A, MMP1
23	egcg32	8.5	TGFB2, TIMP1, SP1, IL1A, MMP1
24	paclitaxel32 34 9 9	11.5	TIMP1, SP1, IL1A, GSN, MMP1
25	n acetylcysteine32	8.4	MMP1, AKR1B1, SP1, TIMP1, TGFB2
26	12-o-tetradecanoylphorbol 13-acetate32	8.4	MMP1, IL1A, SP1, NGF, TIMP1
27	norepinephrine32 9 18 9	11.4	TIMP1, NGF, AKR1B1, IL1A, MMP1
28	sb 20358032 42	9.4	TIMP1, NGF, SP1, IL1A, MMP1
29	aspirin32 34 18	10.4	TFF3, TIMP1, NGF, AKR1B1, MMP1
30	vitamin d32	8.3	TGFB2, TIMP1, NGF, SP1, IL1A, GSN
31	forskolin32 42 9 9	11.3	TGFB2, NGF, SP1, GJB2, IL1A
32	actinomycin d32	8.3	TFF3, TIMP1, NGF, SP1, AKR1B1, IL1A
33	pd 98,05932	8.2	TFF3, TIMP1, NGF, SP1, MMP1
34	cyclosporin a32 42	9.1	TGFB2, TIMP1, NGF, AKR1B1, IL1A, MMP1
35	calcitriol32 42 9 18 9	12.1	TGFB2, TIMP1, NGF, SP1, IL1A, MMP1
36	matrigel32	8.1	MMP1, GJB2, NGF, TIMP1, TGFB2
37	testosterone32 9 18 9	11.1	TGFB2, NGF, SP1, AKR1B1, IL1A, GSN
38	arginine32	8.1	TGFBI, TIMP1, KRT3, KRT12, NGF, SP1
39	glutamine32	7.9	LCAT, TGFBI, TGFB2, TIMP1, NGF, SP1
40	genistein32 9 18 9	10.8	TGFB2, TIMP1, NGF, SP1, AKR1B1, IL1A
41	cycloheximide32	7.8	TGFB2, TIMP1, NGF, SP1, AKR1B1, IL1A
42	dexamethasone32 42 34 9 9	11.8	TGFB2, TIMP1, NGF, SP1, IL1A, MMP1
43	pge232	7.8	TFF3, TGFB2, TIMP1, SP1, AKR1B1, IL1A
44	indomethacin32 9 9	9.7	TFF3, TGFB2, TIMP1, NGF, AKR1B1, IL1A
45	estrogen32	7.6	TFF3, TGFB2, TIMP1, SP1, AKR1B1, MMP1
46	paraffin32	7.6	MMP1, GJB2, TIMP1, TGFB2, TFF3
47	vegf32	7.4	TFF3, TGFB2, TIMP1, NGF, SP1, AKR1B1
48	cysteine32	7.3	TFF3, TGFBI, TGFB2, TIMP1, SP1, AKR1B1
49	retinoic acid32 42 18	9.2	TGFB2, TIMP1, NGF, SP1, GJB2, IL1A
50	serine32	7.0	TGFBI, TGFB2, TIMP1, NGF, SP1, AKR1B1

Cellular components related to corneal disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.3	TGFB2, NGF, AKR1B1, IL1A, GSN, LCAT
2	extracellular region	GO:005576	6.4	LCAT, TFF3, TGFBI, TGFB2, TIMP1, NGF

Biological processes related to corneal disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	response to copper ion	GO:046688	9.9	LCAT, IL1A
2	response to peptide hormone stimulus	GO:043434	8.7	NGF, TIMP1, TFF3
3	aging	GO:007568	8.6	GSN, TIMP1, TGFB2