MCID: CRN024
MIFTS: 48

Corneal Disease malady

Eye category

Summaries for Corneal Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your cornea is the outermost layer of your eye. it is clear and shaped like a dome. the cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. it also helps your eye to focus. if you wear contact lenses, they float on top of your corneas. problems with the cornea include refractive errors allergies infections injuries dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material treatments of corneal disorders include medicines, corneal transplantation, and corneal laser surgery. nih national eye institute

MalaCards: Corneal Disease, also known as corneal diseases, is related to bullous keratopathy and arthritis. An important gene associated with Corneal Disease is CHST6 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6), and among its related pathways are NF-KappaB Family Pathway and Akt Signaling. The drug deferoxamine mesylate and the compounds rantes and estrogen have been mentioned in the context of this disorder. Affiliated tissues include spleen, heart and small intestine, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:64 The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.... more...

Aliases & Classifications for Corneal Disease

Sources:
31LifeMap Discovery™, 8Disease Ontology, 45Novoseek, 61UMLS, 34MedlinePlus, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

corneal disease 31 8
corneal diseases 45 61
corneal disorders 34


External Ids:

Disease Ontology8 DOID:10124
NCIt40 C26731
ICD9CM27 371.9
MeSH35 D003316
ICD1025 H17.9

Related Diseases for Corneal Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Corneal Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1bullous keratopathy30.2IL1A, TGFB2
2arthritis30.0TLR3, TIMP1, MMP1, IL1A, SP1
3limbal stem cell deficiency10.2
4keratoconjunctivitis sicca10.0
5devic disease10.0
6acute myocardial infarction10.0LCAT
7stevens-johnson syndrome10.0KRT3
8primary open angle glaucoma10.0TGFB2
9neuroblastoma10.0NGF
10coronary heart disease10.0LCAT
11allergic rhinitis10.0NGF
12retinal detachment10.0TGFB2
13proliferative vitreoretinopathy10.0TGFB2
14inflammatory bowel disease10.0TFF3
15meesmann corneal dystrophy10.0KRT12, KRT3
16skin disease10.0IL1A
17keratitis10.0GJB2
18keratosis10.0GJB2
19sensorineural hearing loss10.0GJB2
20diabetic retinopathy10.0AKR1B1, TGFB2
21familial mediterranean fever10.0GSN
22lattice corneal dystrophy10.0TGFBI, GSN
23ischemia10.0AKR1B1, TGFB2
24polyneuropathy10.0AKR1B1, GSN
25tuberculosis10.0SP1
26gastric ulcer10.0TFF3
27cholesteatoma10.0IL1A
28lattice corneal dystrophy type 110.0GSN, TGFBI
29amyloidosis corneal10.0TGFBI, GSN
30recurrent corneal erosion10.0TGFBI, KRT12
31sarcoidosis10.0TGFB2, IL1A
32cataract 4, multiple types10.0AKR1B1, TGFB2
33biliary atresia10.0TIMP1
34dementia10.0NGF, SP1
35chondrosarcoma10.0MMP1
36uveitis10.0IL1A, TGFB2
37diabetic autonomic neuropathy10.0AKR1B1, NGF
38myopathy10.0NGF, GSN
39cystic fibrosis10.0GJB2, GSN
40diabetes mellitus10.0LCAT, AKR1B1, NGF
41myocardial infarction10.0AKR1B1, LCAT, SP1
42hepatitis10.0TLR3
43galactosemia10.0TIMP1, LCAT
44liver cirrhosis10.0TIMP1, LCAT
45proliferative diabetic retinopathy10.0TIMP1, TGFB2
46aggressive periodontitis10.0IL1A, MMP1
47amyloid tumor10.0GSN, TGFBI, KRT3, KRT12
48adenoma10.0SP1, TFF3, GSN
49diabetic neuropathy10.0AKR1B1, NGF
50pancreatic cancer10.0SP1, GJB2, TGFB2

Graphical network of the top 20 diseases related to Corneal Disease:



Diseases related to corneal disease

Clinical Features for Corneal Disease

Drugs & Therapeutics for Corneal Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Corneal Disease

Drug clinical trials:

Search ClinicalTrials for Corneal Disease

Search NIH Clinical Center for Corneal Disease

Search CenterWatch for Corneal Disease

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Corneal Disease

Anatomical Context for Corneal Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Corneal Disease:

33
Spleen, Heart, Small intestine, Colon, Kidney, Liver, Thyroid, Skin, T cells, Endothelial

Animal Models for Corneal Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Corneal Disease

Sources:
51PubMed
See all sources

Articles related to Corneal Disease:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Cataract surgery in patients with corneal disease. (23197265)
2013
2
Polymorphism of the transferrin gene in eye diseases: keratoconus and fuchs endothelial corneal dystrophy. (24350254)
2013
3
Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. (22163032)
2011
4
Treatment of corneal disease with traditional Tibetan medicine: a report of four cases. (21505551)
2011
5
Four cases of corneal perforation in patients with chronic graft-versus-host disease. (21386923)
2011
6
Parachlamydia acanthamoebae in domestic cats with and without corneal disease. (20618801)
2010
7
Toxic corneal ulcer: a frequent and sight-threatening disease. (19882588)
2009
8
Managing corneal disease: focus on suppurative keratitis. (20212926)
2009
9
Disruption of CFTR-dependent lipid rafts reduces bacterial levels and corneal disease in a murine model of Pseudomonas aeruginosa keratitis. (18326723)
2008
10
Hyperthyroidism and severity of orbital disease do not change the central corneal thickness in Graves' ophthalmopathy. (18203097)
2008
11
Hypoplastic thyroid, growth hormone deficiency, corneal opacities, cataract and hyperkeratotic skin disease: a possible new ichthyosis syndrome associated with endocrinopathies. (15875205)
2005
12
Cultivated corneal epithelial transplantation for severe ocular surface disease in vernal keratoconjunctivitis. (15829799)
2005
13
Inherited corneal disease: the evolving molecular, genetic and imaging revolution. (15932539)
2005
14
Distribution of TFF peptides in corneal disease and pterygium. (15177877)
2004
15
Mouse genetic corneal disease resulting from transgenic insertional mutagenesis. (14977782)
2004
16
Ex vivo preservation and expansion of human limbal epithelial stem cells on amniotic membrane for treating corneal diseases with total limbal stem cell deficiency. (12614074)
2002
17
A new variant neuropathic type of Gaucher's disease characterized by hydrocephalus, corneal opacities, deformed toes, and fibrous thickening of spleen and liver capsules. (11148530)
2001
18
Corneal opacifications in a low high density lipoprotein syndrome: suspicion of fish eye disease: a case report. (12455137)
2001
19
Pars plana tube insertion of glaucoma drainage implants and penetrating keratoplasty in patients with coexisting glaucoma and corneal disease. (11382628)
2001
20
A new case of Balci's syndrome (corneal opacity, microphthalmia, microcephaly, mental retardation, and generalized muscular spasticity associated with congenital heart disease). (11765173)
2001
21
Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness). (11123754)
2000
22
Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease. (11115257)
2000
23
Management of coincidental corneal disease and cataract. (10178630)
1998
24
High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation. (8627763)
1996
25
Compound heterozygosity for a structural apolipoprotein A-I variant, apo A-I(L141R)Pisa, and an apolipoprotein A-I null allele in patients with absence of HDL cholesterol, corneal opacifications, and coronary heart disease. (8840853)
1996
26
Anterior corneal disease of epidermolysis bullosa simplex. (8470983)
1993
27
Corneal opacity in LCAT disease. (1468226)
1992
28
Metabolic analysis of the diseased human corneal endothelium]. (1502980)
1992
29
A 'Fish-eye disease' familial condition with massive corneal opacities and hypoalphalipoproteinaemia: clinical, biochemical and genetic features. (1778223)
1991
30
Optical pachometry in the measurement of anterior corneal disease: an evaluative tool for phototherapeutic keratectomy. (2297320)
1990
31
Juxtapapillary choroidal neovascular membrane in a patient with Paget's disease and lattice corneal dystrophy. (2477432)
1989
32
Standardized recording of acute corneal disease. (2742288)
1989
33
'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. (3443202)
1987
34
Ophthalmology: viral corneal disease. (18749959)
1986
35
Diabetic corneal disease. (3155119)
1986
36
Iatrogenic peripheral corneal disease. (2433242)
1986
37
The prevalence of corneal disease in the coloured community of a Karoo town. (3992399)
1985
38
Posterior polymorphous corneal dystrophy: a disease characterized by epithelial-like endothelial cells which influence management and prognosis. (3914130)
1985
39
Advances in the diagnosis and management of corneal disease. (6744850)
1984
40
Corneal ulcer disease in Bangladesh. (6362524)
1983
41
Non corneal closed eye electroretinography in healthy persons and in patients with neuronal ceroid lipofuscinosis (Stengel-Batten-Spielmeyer-Vogt disease). (7315215)
1981
42
Inflammatory Terrien's marginal corneal disease. (7270631)
1981
43
Fish-eye disease. A new familial condition with massive corneal opacities and dyslipoproteinaemia. (91022)
1979
44
Current concepts in ophthalmology: Corneal disease. (206829)
1978
45
Structural alteration and destructive corneal disease. (157565)
1978
46
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
47
NEW DEVELOPMENTS IN THE TREATMENT OF CORNEAL DISEASE. (14341367)
1965
48
Conjunctival flaps in the treatment of corneal disease with reference to a new technique of application. (13582332)
1958
49
What the general physician should know about corneal disease. (13377819)
1956
50
Slitlamp diagnosis of corneal and scleral disease. (13080411)
1953

Genetic Variations for Corneal Disease

Expression for genes affiliated with Corneal Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Corneal Disease

Search GEO for disease gene expression data for Corneal Disease.

Pathways for genes affiliated with Corneal Disease

Sources:
52QIAGEN
See all sources

Pathways related to Corneal Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.9TGFB2, IL1A, TLR3, TIMP1
2
Hide members
8.3TGFB2, SP1, IL1A, TLR3, TIMP1

Compounds for genes affiliated with Corneal Disease

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Corneal Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1rantes4510.5IL1A
2estrogen4510.5LCAT
3glutamate4510.3LCAT, GSN
4norepinephrine45 11 2412.3MMP1
5butyrate4510.3LCAT, GSN
6sodium dodecylsulfate4510.2IL1A, LCAT
7epinephrine45 11 2412.0NGF, AKR1B1, IL1A
81-(5-isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride459.8IL1A, TIMP1
9uva 1459.7TIMP1, IL1A, MMP1
10cyclosporin a45 29 6011.7TGFB2, MMP1, NGF, AKR1B1
11guanidine45 11 2411.5TIMP1, LCAT, NGF
12forskolin45 50 1111.5GJB2, SP1
13vitamin d459.5GSN, NGF, SP1, TGFB2
14pge1459.4MMP1, IL1A, LCAT, PTGER3
15ascorbic acid45 2410.3LCAT, TGFB2, AKR1B1, IL1A, MMP1
16glycosaminoglycan459.3IL1A, TGFB2, TIMP1, MMP1
17dihydrotestosterone45 29 11 2412.2SP1, NGF, AKR1B1, TGFB2, GSN
18pdtc459.2SP1, IL1A, MMP1, NGF
19tetracycline45 1110.2SP1, MMP1, IL1A, NGF
20vitamin a45 11 2411.2TIMP1, TGFB2, LCAT, IL1A, MMP1
21azathioprine45 50 2 1112.1SP1, GSN, TIMP1, NGF
22paclitaxel45 50 1111.1GSN, TIMP1, SP1, IL1A
23herbimycin a45 6010.1IL1A, TIMP1, NGF, MMP1
24matrigel459.0TIMP1, NGF, MMP1, GJB2, TGFB2
25hyaluronic acid45 249.9TGFB2, TIMP1, IL1A, MMP1
26prostaglandin458.9IL1A, MMP1, PTGER3, TIMP1, TGFB2
27tgf beta1458.9SP1, TIMP1, MMP1, TGFB2
28curcumin458.8TIMP1, AKR1B1, IL1A, MMP1, SP1
29n acetylcysteine458.8TGFB2, SP1, MMP1, AKR1B1, TIMP1
30dexamethasone45 50 29 1111.8TGFB2, SP1, TLR3, LCAT, TIMP1
3112-o-tetradecanoylphorbol 13-acetate458.7TIMP1, NGF, IL1A, MMP1, SP1
32sb 20358045 609.7IL1A, NGF, SP1, TIMP1, MMP1
33prostacyclin458.7NGF, IL1A, PTGER3, SP1, TIMP1
34aspirin45 50 29 2411.6TFF3, TIMP1, AKR1B1, NGF, MMP1
35calcitriol45 60 11 2411.5TGFB2, IL1A, NGF, TIMP1, MMP1, SP1
36genistein45 29 60 2 11 2413.3TIMP1, AKR1B1, NGF, IL1A, MMP1, SP1
37testosterone45 60 11 2411.3NGF, AKR1B1, LCAT, IL1A, MMP1, SP1
38arginine458.2IL1A, KRT12, KRT3, NGF, AKR1B1, TIMP1
39glutamine458.2TGFBI, TGFB2, NGF, IL1A, TIMP1, LCAT
40actinomycin d458.1IL1A, TIMP1, TFF3, SP1, NGF, AKR1B1
41serine458.1LCAT, TIMP1, SP1, MMP1, IL1A, AKR1B1
42pd 98,059458.0SP1, MMP1, NGF, TIMP1, TFF3
43paraffin457.8TIMP1, MMP1, GJB2, TGFB2, TFF3
44h2o2457.8TIMP1, TFF3, AKR1B1, IL1A, MMP1, SP1
45progesterone45 60 29 11 2411.7TGFB2, PTGER3, MMP1, GJB2, TIMP1, TFF3
46phosphatidylinositol457.6TFF3, TLR3, TIMP1, GSN, NGF, SP1
47indomethacin45 60 29 1110.6NGF, IL1A, MMP1, PTGER3, TGFB2, TFF3
48vegf457.5AKR1B1, TFF3, NGF, IL1A, MMP1, SP1
49retinoic acid45 248.4SP1, GSN, TGFB2, MMP1, GJB2, IL1A
50cysteine457.0SP1, TIMP1, LCAT, TGFB2, TGFBI, GSN

GO Terms for genes affiliated with Corneal Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Corneal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6AKR1B1, NGF, IL1A, GSN, TGFBI, TGFB2
2extracellular regionGO:0055766.8TGFB2, TIMP1, LCAT, TFF3, NGF, IL1A

Biological processes related to Corneal Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.1TGFB2, TGFBI, MMP1, TIMP1
2response to peptide hormone stimulusGO:0434348.6NGF, TFF3, TIMP1

Products for genes affiliated with Corneal Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corneal Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet