MCID: CRN024
MIFTS: 45

Corneal Disease malady

Eye diseases category

Summaries for Corneal Disease

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MedlinePlus:32 Your cornea is the outermost layer of your eye. it is clear and shaped like a dome. the cornea helps to shield the rest of the eye from germs, dust, and other harmful matter. it also helps your eye to focus. if you wear contact lenses, they float on top of your corneas. problems with the cornea include refractive errors allergies infections injuries dystrophies - conditions in which parts of the cornea lose clarity due to a buildup of cloudy material treatments of corneal disorders include medicines, corneal transplantation, and corneal laser surgery. nih: national eye institute

MalaCards based summary: Corneal Disease, also known as corneal diseases, is related to bullous keratopathy and cataract. An important gene associated with Corneal Disease is KRT12 (keratin 12), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and Colorectal Cancer Metastasis. The drug deferoxamine mesylate and the compounds uva 1 and glycosaminoglycan have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and small intestine, and related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Corneal Disease

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Corneal Disease, Aliases & Descriptions:

Name: Corneal Disease 9
Corneal Diseases 43 60
 
Corneal Disorders 32


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:10124
NCIt38 C26731
ICD9CM27 371.9
MeSH33 D003316
ICD1025 H17.9

Related Diseases for Corneal Disease

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Diseases related to Corneal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1bullous keratopathy30.4IL1A, TGFB2
2cataract30.4TGFBI, TGFB2, AKR1B1, GJB2
3arthritis30.3IL1A, TIMP1
4keratoconus29.3SP1, TIMP1, TGFBI, MMP1, GSN, KRT12
5meesmann corneal dystrophy10.5KRT12, KRT3
6oral submucous fibrosis10.4TIMP1, MMP1
7polyneuropathy10.4GSN, AKR1B1
8recurrent corneal erosion10.4KRT12, TGFBI
9periodontitis10.3IL1A
10corneal dystrophy, lattice type i10.3TGFBI, GSN
11corneal dystrophy, gelatinous drop-like10.3GSN, TGFBI
12lattice corneal dystrophy10.3TGFBI, GSN
13nuclear cataract10.3TGFB2, AKR1B1
14herpes simplex10.3
15abdominal aortic aneurysm10.3TIMP1, MMP1
16aggressive periodontitis10.3IL1A, MMP1
17open-angle glaucoma10.3MMP1, TGFB2
18oral lichen planus10.3MMP1, IL1A
19hypertrophic scars10.3TIMP1, MMP1
20middle ear cholesteatoma10.3MMP1, IL1A
21hepatitis c10.3TLR3, TIMP1, MMP1
22diabetic polyneuropathy10.2NGF, AKR1B1
23keratitis10.2
24glomerulosclerosis10.2TIMP1, AKR1B1, LCAT
25diabetic autonomic neuropathy10.2AKR1B1, NGF
26psoriatic arthritis10.2MMP1, IL1A
27diabetic neuropathy10.2AKR1B1, NGF
28pulpitis10.2IL1A, MMP1, TIMP1
29gingival overgrowth10.2TIMP1, MMP1, IL1A
30gingivitis10.2IL1A, MMP1, TIMP1
31vitreoretinopathy, neovascular inflammatory10.2TGFB2, TIMP1
32pulmonary fibrosis10.2MMP1, TGFB2, TIMP1
33synovitis10.2TIMP1, MMP1, IL1A
34autonomic neuropathy10.2AKR1B1, NGF
35periodontal disease10.2TIMP1, MMP1, IL1A
36eye disease10.1NGF
37limbal stem cell deficiency10.1
38endometriosis10.1IL1A, MMP1, TIMP1
39renal fibrosis10.1TGFB2, TIMP1
40sensory peripheral neuropathy10.1NGF, AKR1B1
41skin disease10.1GJB2, IL1A, MMP1
42breast cancer10.1GJB2, GSN, SP1
43keloids10.1MMP1, TGFB2, SP1
44spiradenoma10.1LCAT, TGFB2
45ulcerative colitis10.1TFF3, TLR3, MMP1, IL1A
46keratopathy10.1
47keratoconjunctivitis10.1
48blindness10.1
49conjunctivochalasis10.1MMP1, TIMP1, PTGER3
50corneal dystrophy10.0TGFBI, CHST6, GSN, KRT12, KRT3

Graphical network of the top 20 diseases related to Corneal Disease:



Diseases related to corneal disease

Symptoms for Corneal Disease

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Drugs & Therapeutics for Corneal Disease

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Drug clinical trials:

Search ClinicalTrials for Corneal Disease

Search NIH Clinical Center for Corneal Disease

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Corneal Disease

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Anatomical Context for Corneal Disease

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MalaCards organs/tissues related to Corneal Disease:

31
Eye, T cells, Small intestine, Colon, Testes

Animal Models for Corneal Disease or affiliated genes

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MGI Mouse Phenotypes related to Corneal Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7GSN, TGFB2, TIMP1, TLR3, SP1
2MP:00020068.5TLR3, TIMP1, TGFBI, MMP1, IL1A
3MP:00053918.0SP1, NGF, TGFB2, AKR1B1, LCAT, GJB2
4MP:00053977.4SP1, TLR3, TIMP1, TGFBI, TGFB2, IL1A
5MP:00053876.5TIMP1, PTGER3, TLR3, TFF3, TGFBI, TGFB2
6MP:00053856.4SP1, TLR3, NGF, PTGER3, TIMP1, TGFB2
7MP:00107686.4SP1, TLR3, NGF, PTGER3, TIMP1, TGFBI
8MP:00053764.9GJB2, SP1, TFF3, TLR3, NGF, PTGER3

Publications for Corneal Disease

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Articles related to Corneal Disease:

(show top 50)    (show all 153)
idTitleAuthorsYear
1
Mosaic Chromosome 18q Partial Deletion Syndrome with Bilateral Full-thickness Corneal Disease: Surgical Intervention and Histopathology. (24024746)
2013
2
Cataract surgery in patients with corneal disease. (23197265)
2013
3
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice. (22647700)
2012
4
Pilot Study for OCT Guided Design and Fit of a Prosthetic Device for Treatment of Corneal Disease. (23316338)
2012
5
Correlation of clinical and pathologic diagnoses of corneal disease in penetrating keratoplasties in Vancouver: a 10-year review. (22333843)
2012
6
Histopathology and treatment of corneal disease in keratitis, ichthyosis, and deafness (KID) syndrome. (19590522)
2010
7
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. (20007286)
2010
8
Collagen cross-linking: a new treatment paradigm in corneal disease - a review. (20398104)
2010
9
Disruption of CFTR-dependent lipid rafts reduces bacterial levels and corneal disease in a murine model of Pseudomonas aeruginosa keratitis. (18326723)
2008
10
CD8(+) T cells control corneal disease following ocular infection with herpes simplex virus type 1. (15218191)
2004
11
Laser applications for corneal disease. (14604095)
2003
12
Applications of contact lens devices in the management of corneal disease. (14631391)
2003
13
Prospects for gene therapy in corneal disease. (14631395)
2003
14
Corneal disease in patients with chronic renal insufficiency undergoing hemodialysis. (11588419)
2001
15
Iatrogenic limbal stem cell deficiency: when glaucoma management contributes to corneal disease. (11740212)
2001
16
Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness). (11123754)
2000
17
Acremonium keratitis in a patient with herpetic neurotrophic corneal disease. (10726803)
2000
18
Management of coincident corneal disease and cataract. (10387322)
1999
19
An analysis of 1,001 blinding patients with corneal disease in 1960-1989. (12580077)
1998
20
Corneoscleral transplantation for end stage corneal disease. (9924332)
1998
21
Detection of interleukin-1 beta in the tear fluid of patients with corneal disease with or without conjunctival involvement. (9152805)
1997
22
High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation. (8627763)
1996
23
Changing patterns of corneal disease and associated vision loss at a rural African hospital following a training programme for traditional healers. (8949711)
1996
24
Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis. (8849537)
1995
25
Traditional eye medicine use among patients with corneal disease in rural Malawi. (7848973)
1994
26
Circulating cornea-specific antibodies in corneal disease and cornea transplantation. (8157180)
1994
27
Clinical and diagnostic use of in vivo confocal microscopy in patients with corneal disease. (8414403)
1993
28
Anterior corneal disease of epidermolysis bullosa simplex. (8470983)
1993
29
Compensatory epithelial hyperplasia in human corneal disease. (1484663)
1992
30
Endogenously produced interferon alpha protects mice from herpes simplex virus type 1 corneal disease. (1649898)
1991
31
Corneal disease in Africa. (1782163)
1991
32
Herpes simplex virus--induced destructive corneal disease. (2559859)
1989
33
Botulinum toxin A-induced protective ptosis in corneal disease. (3050691)
1988
34
Ophthalmology: viral corneal disease. (18749959)
1986
35
Diabetic corneal disease. (3155119)
1986
36
The prevalence of corneal disease in the coloured community of a Karoo town. (3992399)
1985
37
A new bandage lens for treatment of corneal disease: Softcon XT. (6509765)
1984
38
Inflammatory Terrien's marginal corneal disease. (7270631)
1981
39
Primary corneal disease in the dog and cat. (6251593)
1980
40
Destructive corneal disease in the connective tissue disorders. Comparison with an experimental animal model. (38536)
1978
41
Use of anti-inflammatory agents in destructive corneal disease. (382459)
1978
42
Neglected lid deformities causing progressive corneal disease. Surgical correction of entropion, trichiasis, marginal keratinization, and functional lid shortening. (1087767)
1976
43
The Bausch and Lomb "T" lens in the treatment of corneal disease. (1070889)
1976
44
The use of therapeutic soft contact lenses in corneal disease. (1152538)
1975
45
Complications in use of soft contact lenses in corneal disease. (4746087)
1973
46
A simple scheme for documenting corneal disease. (4127939)
1973
47
Topically applied steroids in corneal disease. II. The role of drug vehicle in stromal absorption of dexamethasone. (4634795)
1972
48
Hydrophilic contact lenses in corneal disease. 3. Topical hypertonic saline therapy in bullous keratopathy. (5315226)
1971
49
Diagnosing corneal disease. (5726393)
1968
50
Corneal disease. (5903646)
1966

Variations for Corneal Disease

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Expression for genes affiliated with Corneal Disease

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Search GEO for disease gene expression data for Corneal Disease.

Pathways for genes affiliated with Corneal Disease

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Pathways related to Corneal Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MMP1, TIMP1
29.5MMP1, TGFB2, TLR3
39.3TGFB2, MMP1, IL1A
4
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.2IL1A, TLR3, SP1
5
Show member pathways
9.1IL1A, TGFB2, TIMP1, TLR3
69.0SP1, NGF, IL1A
7
Show member pathways
8.6SP1, TLR3, TIMP1, TGFB2, IL1A

Compounds for genes affiliated with Corneal Disease

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Compounds related to Corneal Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1uva 1439.9IL1A, MMP1, TIMP1
2glycosaminoglycan439.2IL1A, MMP1, TGFB2, TIMP1
3sodium dodecylsulfate439.2MMP1, IL1A, LCAT, GSN
4rantes439.2TLR3, TIMP1, TGFB2, MMP1, IL1A
5matrigel439.1NGF, TIMP1, TGFB2, MMP1, GJB2
6vitamin a43 24 1211.1TIMP1, TGFB2, MMP1, IL1A, LCAT
7pdtc439.1IL1A, MMP1, NGF, SP1
8azathioprine43 2 49 1212.0GSN, TIMP1, NGF, SP1
9curcumin439.0SP1, TIMP1, MMP1, AKR1B1, IL1A
10tetracycline43 1210.0SP1, NGF, MMP1, IL1A
11n acetylcysteine439.0SP1, TIMP1, TGFB2, MMP1, AKR1B1
12ascorbic acid43 2410.0TGFB2, MMP1, AKR1B1, IL1A, LCAT
13egcg438.9SP1, TIMP1, TGFB2, MMP1, IL1A
14pge1438.9PTGER3, MMP1, IL1A, LCAT
15aspirin43 49 28 2411.8TFF3, NGF, TIMP1, MMP1, AKR1B1
16paclitaxel43 49 1210.8SP1, TIMP1, MMP1, IL1A, GSN
17dihydrotestosterone43 28 24 1211.8SP1, NGF, TGFB2, AKR1B1, GSN
18norepinephrine43 24 1210.8NGF, TIMP1, MMP1, AKR1B1, IL1A
19epinephrine43 24 1210.7SP1, NGF, MMP1, AKR1B1, IL1A
2012-o-tetradecanoylphorbol 13-acetate438.7IL1A, MMP1, TIMP1, NGF, SP1
21sb 20358043 599.7SP1, NGF, TIMP1, MMP1, IL1A
22tgf beta1438.7SP1, TIMP1, TGFB2, MMP1
23butyrate438.6SP1, TFF3, TIMP1, LCAT, GSN
24prostaglandin438.6PTGER3, TIMP1, TGFB2, MMP1, IL1A
25cyclosporin a43 28 5910.6NGF, TIMP1, TGFB2, MMP1, AKR1B1, IL1A
26paraffin438.6GJB2, MMP1, TGFB2, TIMP1, TFF3
27calcitriol43 59 24 1211.4SP1, NGF, TIMP1, TGFB2, MMP1, IL1A
28vitamin d438.4SP1, NGF, TIMP1, TGFB2, IL1A, GSN
29forskolin43 49 1210.3GJB2, IL1A, TGFB2, NGF, SP1
30h2o2438.3SP1, TFF3, TIMP1, MMP1, AKR1B1, IL1A
31prostacyclin438.3IL1A, TIMP1, PTGER3, NGF, SP1
32pd 98,059438.3SP1, TFF3, NGF, TIMP1, MMP1
33actinomycin d438.2SP1, TFF3, NGF, TIMP1, AKR1B1, IL1A
34genistein43 28 59 2 24 1213.1SP1, NGF, TIMP1, TGFB2, MMP1, AKR1B1
35cycloheximide438.1SP1, NGF, TIMP1, TGFB2, MMP1, AKR1B1
36estrogen438.0SP1, TFF3, TIMP1, TGFB2, MMP1, AKR1B1
37arginine438.0SP1, NGF, TIMP1, TGFBI, AKR1B1, IL1A
38glutamate438.0SP1, NGF, TIMP1, TGFB2, IL1A, LCAT
39phosphatidylinositol437.9SP1, TFF3, TLR3, NGF, TIMP1, TGFB2
40dexamethasone43 49 28 1210.8SP1, TLR3, NGF, TIMP1, TGFB2, MMP1
41progesterone43 28 59 24 1211.8TFF3, PTGER3, TIMP1, TGFB2, MMP1, IL1A
42testosterone43 59 24 1210.8SP1, NGF, TGFB2, MMP1, AKR1B1, IL1A
43glutamine437.7SP1, NGF, TIMP1, TGFBI, TGFB2, AKR1B1
44retinoic acid43 248.6SP1, TLR3, NGF, TIMP1, TGFB2, MMP1
45vegf437.5SP1, TFF3, NGF, TIMP1, TGFB2, MMP1
46indomethacin43 28 59 1210.2IL1A, TFF3, NGF, PTGER3, TIMP1, TGFB2
47pge2437.2SP1, TFF3, PTGER3, TIMP1, TGFB2, MMP1
48cysteine437.0SP1, TFF3, NGF, TIMP1, TGFBI, TGFB2
49serine436.9SP1, TLR3, NGF, TIMP1, TGFBI, TGFB2
50tyrosine436.8SP1, TFF3, TLR3, NGF, PTGER3, TIMP1

GO Terms for genes affiliated with Corneal Disease

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Cellular components related to Corneal Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1TGFBI, TGFB2, AKR1B1, IL1A, LCAT, NGF
2extracellular regionGO:00055766.6GSN, TFF3, NGF, TIMP1, TGFBI, TGFB2

Biological processes related to Corneal Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:00301989.1MMP1, TGFB2, TGFBI, TIMP1
2response to peptide hormoneGO:00434348.8TIMP1, NGF, TFF3

Products for genes affiliated with Corneal Disease

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  • Antibodies
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  • Kits and Assays

Sources for Corneal Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet