Aliases & Classifications for Corneal Dystrophy

MalaCards integrated aliases for Corneal Dystrophy:

Name: Corneal Dystrophy 12 72 28 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2566
ICD10 32 H18.5 H18.50
ICD9CM 34 371.5 371.50
MeSH 41 D003317

Summaries for Corneal Dystrophy

MalaCards based summary : Corneal Dystrophy is related to corneal dystrophy, avellino type and corneal dystrophy, reis-bucklers type. An important gene associated with Corneal Dystrophy is ZEB1 (Zinc Finger E-Box Binding Homeobox 1). The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes, and related phenotype is vision/eye.

Wikipedia : 72 Corneal dystrophy is a group of rare hereditary disorders characterised by bilateral abnormal deposition... more...

Related Diseases for Corneal Dystrophy

Diseases related to Corneal Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 corneal dystrophy, avellino type 34.5 CHST6 TGFBI
2 corneal dystrophy, reis-bucklers type 34.1 TACSTD2 TGFBI
3 corneal dystrophy, lattice type i 34.1 GSN TGFBI
4 corneal dystrophy, endothelial, x-linked 33.9 SLC4A11 VSX1
5 corneal dystrophy, meesmann 33.8 CHST6 COL8A2 KRT12 KRT3 TGFBI
6 macular dystrophy, corneal 33.8 CHST6 KRT12 TGFBI UBIAD1
7 corneal dystrophy, posterior polymorphous, 2 33.5 COL8A2 SLC4A11 VSX1 ZEB1
8 corneal dystrophy, fuchs endothelial, 3 33.5 MBNL1 TCF4
9 lattice corneal dystrophy 33.5 GSN TACSTD2 TGFBI
10 corneal dystrophy, posterior polymorphous, 1 33.4 COL8A2 OVOL2 SLC4A11 VSX1 ZEB1
11 corneal dystrophy, gelatinous drop-like 33.4 CHST6 GSN KRT12 TACSTD2 TGFBI
12 corneal dystrophy, posterior polymorphous, 3 33.1 COL8A2 OVOL2 SLC4A11 VSX1 ZEB1
13 epithelial basement membrane dystrophy 33.1 COL8A2 TGFBI
14 corneal dystrophy, thiel-behnke type 32.6 CHST6 COL8A2 GSN KRT12 KRT3 SLC4A11
15 corneal granular dystrophy 32.2 KRT12 KRT3 TGFBI UBIAD1
16 corneal endothelial dystrophy 32.1 CHST6 COL8A2 KRT12 KRT3 OVOL2 SLC4A11
17 fuchs' endothelial dystrophy 32.0 AGBL1 COL8A1 COL8A2 SLC4A11 TCF4 TGFBI
18 corneal degeneration 30.0 KRT12 TGFBI VSX1
19 corneal edema 29.7 COL8A2 SLC4A11
20 keratoconus 29.5 COL8A2 GSN KRT12 KRT3 TGFBI VSX1
21 corneal dystrophy, congenital stromal 12.6
22 corneal dystrophy, epithelial basement membrane 12.6
23 corneal dystrophy, groenouw type i 12.6
24 schnyder corneal dystrophy 12.6
25 corneal dystrophy, fleck 12.6
26 corneal dystrophy and perceptive deafness 12.5
27 corneal dystrophy, lattice type iiia 12.5
28 corneal dystrophy, fuchs endothelial, 1 12.4
29 corneal dystrophy, fuchs endothelial, 2 12.3
30 corneal dystrophy, lisch epithelial 12.3
31 lattice corneal dystrophy type ii 12.3
32 corneal dystrophy, posterior amorphous 12.3
33 corneal dystrophy, fuchs endothelial, 4 12.3
34 corneal dystrophy, fuchs endothelial, 6 12.3
35 corneal dystrophy, subepithelial mucinous 12.3
36 corneal dystrophy, fuchs endothelial, 5 12.2
37 corneal dystrophy, fuchs endothelial, 8 12.2
38 spinocerebellar degeneration and corneal dystrophy 12.2
39 pre-descemet corneal dystrophy 12.1
40 grayson-wilbrandt corneal dystrophy 12.0
41 honey-droplet corneal dystrophy 12.0
42 corneal dystrophy, fuchs endothelial, 7 12.0
43 amyloidosis, finnish type 12.0
44 corneal dystrophy, band-shaped 12.0
45 spinocerebellar degeneration with macular corneal dystrophy, congenital cataracts, and myopia 11.9
46 congenital labioscrotal agenesis-cerebellar malformation-corneal dystrophy-facial dysmorphism syndrome 11.9
47 spondyloepiphyseal dysplasia with punctate corneal dystrophy 11.9
48 corneal dystrophy ichthyosis microcephaly mental retardation 11.9
49 corneal dystrophy pigmentary anomaly malabsorption 11.9
50 corneodermatoosseous syndrome 11.8

Graphical network of the top 20 diseases related to Corneal Dystrophy:



Diseases related to Corneal Dystrophy

Symptoms & Phenotypes for Corneal Dystrophy

MGI Mouse Phenotypes related to Corneal Dystrophy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.4 CHST6 COL8A1 COL8A2 DCN KRT12 MBNL1

Drugs & Therapeutics for Corneal Dystrophy

Drugs for Corneal Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 129260-79-3, 82034-46-6 9865442 444025
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
4 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
5 Anti-Allergic Agents Phase 4,Phase 2
6 Antiemetics Phase 4,Phase 2
7 Anti-Inflammatory Agents Phase 4,Phase 2
8 Antineoplastic Agents, Hormonal Phase 4,Phase 2
9 Autonomic Agents Phase 4,Phase 1,Phase 2
10 Gastrointestinal Agents Phase 4,Phase 2
11 glucocorticoids Phase 4,Phase 2
12 Hormone Antagonists Phase 4,Phase 2
13 Hormones Phase 4,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
15 Methylprednisolone acetate Phase 4,Phase 2
16 Methylprednisolone Hemisuccinate Phase 4,Phase 2
17 Neuroprotective Agents Phase 4,Phase 2
18 Ophthalmic Solutions Phase 4,Phase 3,Phase 1,Phase 2
19 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
20 Prednisolone acetate Phase 4,Phase 2
21 Prednisolone hemisuccinate Phase 4,Phase 2
22 Prednisolone phosphate Phase 4,Phase 2
23 Protective Agents Phase 4,Phase 2,Phase 1
24 Tetrahydrozoline Phase 4,Phase 3,Phase 1,Phase 2
25
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
26 Vitamin B2 Nutraceutical Phase 3
27
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
28
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
29
Fluorometholone Approved, Investigational Phase 2 426-13-1 9878
30
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
31 Nasal Decongestants Phase 1, Phase 2
32 Respiratory System Agents Phase 1, Phase 2
33 Vasoconstrictor Agents Phase 1, Phase 2
34 HIV Protease Inhibitors Phase 2
35
protease inhibitors Phase 2
36 BB 1101 Phase 2
37 Dexamethasone acetate Phase 2 1177-87-3
38
Fomepizole Approved, Vet_approved Phase 1 7554-65-6 3406
39 Antidotes Phase 1
40
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759
41 Matrix Metalloproteinase Inhibitors
42 Superoxide Dismutase
43 TIMP1 protein, human
44 TIMP3 protein, human
45 Tissue Inhibitor of Metalloproteinase-1
46 Tissue Inhibitor of Metalloproteinase-3
47 Tissue Inhibitor of Metalloproteinases
48 Adjuvants, Immunologic
49 Viscosupplements
50 Anti-Bacterial Agents

Interventional clinical trials:

(show top 50) (show all 56)

# Name Status NCT ID Phase Drugs
1 Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT01357122 Phase 4
2 Fuchs' Torsional Phaco Study Completed NCT00781027 Phase 4
3 Comparison of Corticosteroid Dosing Regimens After Endothelial Keratoplasty Completed NCT01853696 Phase 4 loteprednol etabonate;prednisolone acetate 1%
4 Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy Not yet recruiting NCT03249337 Phase 4 Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
5 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
6 The Effects of Corneal Collagen Cross-linking Recruiting NCT01708538 Phase 3 CXL
7 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Recruiting NCT03248037 Phase 3 Netarsudil;Placebo
8 Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing Completed NCT02746848 Phase 1, Phase 2
9 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
10 Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study Recruiting NCT02834260 Phase 2 Dexamethasone implant OZURDEX
11 A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED) Active, not recruiting NCT02653391 Phase 1, Phase 2 Elamipretide 1.0% Ophthalmic Solution;Elamipretide 3.0% Ophthalmic Solution
12 Phase 1 Pilot Study of 4-MP to Treat Stargardt Macular Dystrophy Completed NCT00346853 Phase 1 4-Methylpyrazole
13 The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy Unknown status NCT01795001
14 Descemet Stripping (Automated) Endothelial Keratoplasty (DSEK or DSAEK) Unknown status NCT00543660
15 Corneal Endothelium Morphology and Central Thickness in Type II Diabetes Mellitus and Normal Subjects Unknown status NCT01084850
16 Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty Unknown status NCT00744796
17 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
18 DSAEK- Postoperative Positioning and Transplant Dislocation Unknown status NCT01206127
19 Clinical Efficacy of the Pinhole Soft Contact Lenses for Correcting Presbyopia Unknown status NCT02612584
20 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
21 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044
22 Spectral-domain Optical Coherence Tomography of the Eye Unknown status NCT02614625
23 Cornea Donor Study Unknown status NCT00006411
24 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075
25 Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases Completed NCT00357435
26 Combined Cataract Surgery and Planned Descemetorhexis Completed NCT02206594
27 Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology Completed NCT01979250
28 Optimizing the Ocular Surface Prior to Cataract Surgery Completed NCT02766907
29 Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas Completed NCT03071302
30 Laser Assisted Procedures in Penetrating Keratoplasty Completed NCT02173847
31 ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy Completed NCT02332109
32 Comparison of Two Techniques in Achieving Corneal Graft Completed NCT01610973
33 Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty Completed NCT00624221
34 Long Term Cornea Graft Survival Study Completed NCT02849808
35 PIONEER: Intraoperative and Perioperative OCT Study Completed NCT02423161
36 Impact of Cataract Surgery on Keratoplasty Graft Survival Completed NCT02875145
37 A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema Completed NCT00346138
38 Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT Recruiting NCT02542644
39 Descemet Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT00521898
40 Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases Recruiting NCT02932852 Early Phase 1
41 DMEK Versus DSAEK Study Recruiting NCT02793310
42 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151 Salt solution
43 Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP Recruiting NCT02826174 Anti-Rejection Agents;Anti-Inflammatory Agents
44 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111
45 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
46 Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye Recruiting NCT00343473
47 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755
48 Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystrophy Recruiting NCT03275896 Early Phase 1
49 DISCOVER Study: Microscope-integrated Intraoperative OCT Study Recruiting NCT02423213
50 Technique And Results In Endothelial Keratoplasty Recruiting NCT02470793

Search NIH Clinical Center for Corneal Dystrophy

Genetic Tests for Corneal Dystrophy

Genetic tests related to Corneal Dystrophy:

# Genetic test Affiliating Genes
1 Corneal Dystrophy 28

Anatomical Context for Corneal Dystrophy

MalaCards organs/tissues related to Corneal Dystrophy:

38
Endothelial, Eye, Testes, Kidney, Cerebellum, Skin

Publications for Corneal Dystrophy

Articles related to Corneal Dystrophy:

(show top 50) (show all 863)
# Title Authors Year
1
Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model. ( 29338061 )
2018
2
Factors Influencing Visual Acuity in Fuchs' Endothelial Corneal Dystrophy. ( 29252902 )
2018
3
Long-term Clinical Outcomes of Phototherapeutic Keratectomy in Corneas With Granular Corneal Dystrophy Type 2 Exacerbated After LASIK. ( 29425392 )
2018
4
Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy. ( 29408827 )
2018
5
NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy. ( 29294389 )
2018
6
Fuchs endothelial corneal dystrophy and macular drusen: evidence for coincidence? ( 29350686 )
2018
7
Association Between Visual Acuity and the Corneal Area Occupied by Granular Lesions, Linear Lesions, or Diffuse Haze in Patients With Granular Corneal Dystrophy Type 2. ( 29443809 )
2018
8
Post-LASIK exacerbation of granular corneal dystrophy type 2 in members of a chinese family. ( 29192679 )
2018
9
Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome. ( 29343529 )
2018
10
Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy. ( 29384808 )
2018
11
Long-Term Outcome After Penetrating Keratoplasty in a Pedigree With the G177E Mutation in the UBIAD1 Gene for Schnyder Corneal Dystrophy. ( 29319599 )
2018
12
Defect in phosphoinositide signalling through a homozygous variant in<i>PLCB3</i>causes a new form of spondylometaphyseal dysplasia with corneal dystrophy. ( 29122926 )
2018
13
Posterior Amorphous Corneal Dystrophy Associated With Keratoglobus: A Case Report. ( 28902010 )
2017
14
CTG18.1 Expansion in TCF4 Increases Likelihood of Transplantation in Fuchs Corneal Dystrophy. ( 27755191 )
2017
15
Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy. ( 28118661 )
2017
16
Repair of the TGFBI gene in human corneal keratocytes derived from a granular corneal dystrophy patient via CRISPR/Cas9-induced homology-directed repair. ( 29196743 )
2017
17
Recurrence of Granular Corneal Dystrophy Type 1 After Phototherapeutic Keratectomy, Lamellar Keratoplasty, and Penetrating Keratoplasty in a Single Population. ( 28749898 )
2017
18
Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy. ( 28727885 )
2017
19
The Changing Face of Aging: Highly Sulfated Glycosaminoglycans Induce Amyloid Formation in a Lattice Corneal Dystrophy Model Protein. ( 28739480 )
2017
20
Endothelial keratoplasty for posterior polymorphous corneal dystrophy in a 4-month-old infant. ( 29260073 )
2017
21
In vivo confocal microscopy of pre-Descemet corneal dystrophy associated with X-linked ichthyosis: a case report. ( 28302098 )
2017
22
Gelatinous drop-like corneal dystrophy: a review. ( 27913443 )
2017
23
Unilateral lattice corneal dystrophy in a young female: A unique case report. ( 29022958 )
2017
24
Photorefractive Keratectomy With Mitomycin C in Meesmann's Epithelial Corneal Dystrophy. ( 28068448 )
2017
25
Vortex Pattern of Corneal Deposits in Granular Corneal Dystrophy Associated With the p.(Arg555Trp) Mutation in TGFBI. ( 28060069 )
2017
26
CTG18.1 Expansion in TCF4 Among African Americans With Fuchs' Corneal Dystrophy. ( 29196769 )
2017
27
Two mutations in the transforming growth factor beta-induced gene associated with familial Lattice corneal dystrophy. ( 28393022 )
2017
28
Fuchs' Endothelial and Myotonic Dystrophies: Corneal Dystrophy in Myotonic Patients. ( 29136408 )
2017
29
Proteomic Analysis of Amyloid Corneal Aggregates from TGFBI-H626R Lattice Corneal Dystrophy Patient Implicates Serine-Protease HTRA1 in Mutation-Specific Pathogenesis of TGFBIp. ( 28689406 )
2017
30
Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy. ( 28886202 )
2017
31
Mutation analysis of TGFBI and KRT12 in a case of concomitant keratoconus and granular corneal dystrophy. ( 28567551 )
2017
32
Corneal Backscatters as an Objective Index for Assessing Fuchs' Endothelial Corneal Dystrophy: A Pilot Study. ( 28751984 )
2017
33
Posterior Polymorphous Corneal Dystrophy ( 28613630 )
2017
34
Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. ( 28751712 )
2017
35
Association of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study. ( 29044056 )
2017
36
Agenesis of the corpus callosum, developmental delay, autism spectrum disorder, facial dysmorphism, and posterior polymorphous corneal dystrophy associated with ZEB1 gene deletion. ( 28742278 )
2017
37
Effect of position-specific single-point mutations and biophysical characterization of amyloidogenic peptide fragments identified from lattice corneal dystrophy patients. ( 28381645 )
2017
38
Meretoja's Syndrome: Lattice Corneal Dystrophy, Gelsolin Type. ( 28250773 )
2017
39
Peripheral Endothelial Cell Count Is a Predictor of Disease Severity in Advanced Fuchs Endothelial Corneal Dystrophy. ( 28731879 )
2017
40
Melatonin reduces endoplasmic reticulum stress and corneal dystrophy-associated TGFBIp through activation of endoplasmic reticulum-associated protein degradation. ( 28580641 )
2017
41
Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy. ( 28654985 )
2017
42
Mutation-Induced Deamidation of Corneal Dystrophy-Related Transforming Growth Factor I^-Induced Protein. ( 29140698 )
2017
43
Confirmation of the OVOL2 Promoter Mutation c.-307T>C in Posterior Polymorphous Corneal Dystrophy 1. ( 28046031 )
2017
44
Activation of TGF-I^ signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy. ( 28754918 )
2017
45
Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model. ( 28726551 )
2017
46
<i>CHST6</i> mutation screening and endoplasmatic reticulum stress in macular corneal dystrophy. ( 29221207 )
2017
47
Automated Retroillumination Photography Analysis for Objective Assessment of Fuchs Corneal Dystrophy. ( 27811565 )
2017
48
Transforming growth factor I^ induced mutation-associated phenotype in a Chinese family exhibiting lattice corneal dystrophy. ( 29085627 )
2017
49
Intracorneal melatonin delivery using 2-hydroxypropyl-I^-cyclodextrin ophthalmic solution for granular corneal dystrophy type 2. ( 28694094 )
2017
50
TGC repeat expansion in the TCF4 gene increases the risk of Fuchs' endothelial corneal dystrophy in Australian cases. ( 28832669 )
2017

Variations for Corneal Dystrophy

ClinVar genetic disease variations for Corneal Dystrophy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ZEB1 NM_030751.5(ZEB1): c.1576dup (p.Val526Glyfs) duplication Pathogenic rs766305306 GRCh37 Chromosome 10, 31809839: 31809839

Expression for Corneal Dystrophy

Search GEO for disease gene expression data for Corneal Dystrophy.

Pathways for Corneal Dystrophy

GO Terms for Corneal Dystrophy

Cellular components related to Corneal Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.46 COL8A1 COL8A2 DCN TGFBI
2 proteinaceous extracellular matrix GO:0005578 9.26 COL8A1 COL8A2 DCN TGFBI
3 basement membrane GO:0005604 8.8 COL8A1 COL8A2 TGFBI

Biological processes related to Corneal Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.46 COL8A1 COL8A2 OVOL2 TGFBI
2 camera-type eye morphogenesis GO:0048593 9.32 COL8A1 COL8A2
3 epithelial cell proliferation GO:0050673 9.26 COL8A1 COL8A2
4 extracellular matrix organization GO:0030198 9.26 COL8A1 COL8A2 DCN TGFBI
5 visual perception GO:0007601 8.92 KRT12 TACSTD2 TGFBI VSX1

Molecular functions related to Corneal Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.26 OVOL2 TCF4 VSX1 ZEB1
2 extracellular matrix binding GO:0050840 8.62 DCN TGFBI

Sources for Corneal Dystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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