Summaries for Corneal Edema

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MalaCards based summary: Corneal Edema, also known as unspecified corneal edema, is related to keratoconus and corneal dystrophy, posterior polymorphous, 1. An important gene associated with Corneal Edema is KRT8 (keratin 8), and among its related pathways are Matrix Metalloproteinases and Cell adhesion Cell matrix glycoconjugates. The drugs sodium chloride and sodium chloride granules and the compounds uva 1 and ilomastat have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related mouse phenotypes are vision/eye and immune system.

Aliases & Classifications for Corneal Edema

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Corneal Edema, Aliases & Descriptions:

Name: Corneal Edema 10 12 62
Unspecified Corneal Edema 10 62
Corneal Edema, Unspecified 10
 
Corneal Edema Nos 10
Corneal Oedema 10
Cornea Edema 10


External Ids:

Disease Ontology10 DOID:11030
MeSH35 D015715
ICD9CM29 371.2, 371.20
NCIt40 C50508

Related Diseases for Corneal Edema

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Diseases in the Corneal Edema family:

Secondary Corneal Edema

Diseases related to Corneal Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconus30.6FBXO7, MMP3, MMP1, VSX1
2corneal dystrophy, posterior polymorphous, 130.1VSX1
3corneal dystrophy30.1SLC4A11, VSX1, FBXO7
4keratopathy30.1FBXO7, PBK
5cataract10.7
6endotheliitis10.6
7idiopathic corneal edema10.4
8contact lens corneal edema10.3
9secondary corneal edema10.3
10uveitis10.3
11keratitis10.3
12hypoxia10.3
13fuchs' endothelial dystrophy10.2
14retinitis10.2
15anterior uveitis10.2
16interstitial keratitis10.1
17tularemia10.1
18intervertebral disc disease10.0IL1B
19corneal dystrophy, fuchs endothelial, 510.0
20corneal dystrophy, fuchs endothelial, 610.0
21corneal dystrophy, fuchs endothelial, 810.0
22corneal dystrophy, fuchs endothelial, 410.0
23glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.0
24pearson syndrome10.0
25rubella10.0
26exophthalmos10.0
27recurrent corneal erosion10.0
28coloboma10.0
29bullous keratopathy10.0
30allergic conjunctivitis10.0
31conjunctivitis10.0
32herpes simplex10.0
33keratoconjunctivitis10.0
34melanoma10.0
35neuropathy10.0
36retinal detachment10.0
37congenital rubella10.0
38pellucid marginal degeneration10.0
39stromal keratitis10.0
40essential iris atrophy10.0
41periodontitis10.0IL1B
42irregular astigmatism10.0VSX1, FBXO7
43epidermolysis bullosa dystrophica10.0MMP1, MMP3
44conjunctivochalasis10.0MMP1, MMP3
45gingivitis10.0MMP1, IL1B
46abdominal aortic aneurysm10.0MMP1, MMP3
47basal cell carcinoma10.0KRT8, MMP1, MMP3
48pulmonary fibrosis10.0MMP1, IL1B, KRT8
49pulmonary fibrosis, idiopathic10.0MMP1, IL1B
50fibrosarcoma10.0KRT8, MMP1, MMP3

Graphical network of the top 20 diseases related to Corneal Edema:



Diseases related to corneal edema

Symptoms for Corneal Edema

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Drugs & Therapeutics for Corneal Edema

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Drug clinical trials:

Search ClinicalTrials for Corneal Edema

Search NIH Clinical Center for Corneal Edema

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Corneal Edema

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Anatomical Context for Corneal Edema

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MalaCards organs/tissues related to Corneal Edema:

33
Eye, Endothelial

Animal Models for Corneal Edema or affiliated genes

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MGI Mouse Phenotypes related to Corneal Edema:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6SLC4A11, VSX1, OVOL2, FBXO7
2MP:00053877.6KRT8, FBXO7, MMP3, MMP1, PBK, IL1B

Publications for Corneal Edema

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Articles related to Corneal Edema:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Transient corneal edema is a predictive factor for pseudophakic cystoid macular edema after uncomplicated cataract surgery. (25646056)
2015
2
Acute corneal edema with subsequent thinning and hyperopic shift following selective laser trabeculoplasty. (25263043)
2014
3
Amantadine induced corneal edema in a patient with primary progressive freezing of gait. (24868424)
2013
4
Pseudophakic/aphakic corneal edema--morphometric predisposing factors analysis based on the fellow eye examination. (23461150)
2012
5
Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation. (21896863)
2011
6
Determinants of postoperative corneal edema and impact on goldmann intraocular pressure. (21505325)
2011
7
Is excimer laser corneal surgery appropriate after resolution of corneal edema in fuchs dystrophy by descemet membrane endothelial keratoplasty? (20540467)
2011
8
Amantadine-associated corneal edema treated with descemet's stripping automated endothelial keratoplasty. (21158374)
2010
9
Corneal graft detachment without corneal edema after descemet stripping automated endothelial keratoplasty. (20164759)
2010
10
Effect of incident light wavelength and corneal edema on light scattering and penetration: laboratory study of human corneas. (20954687)
2010
11
Amantadine-associated corneal edema. (19486806)
2009
12
Late corneal edema due to retained foldable lens fragment. (19384021)
2009
13
Reversible corneal edema associated with amantadine use: an unrecognized problem. (18785231)
2008
14
Corneal edema after aqueous drainage device implantation. (17571002)
2007
15
Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the Veterans Health Administration. (17893540)
2007
16
The effect of contact lens induced corneal edema on Goldmann applanation tonometry measurements. (17224766)
2007
17
Time to resolution of corneal edema after long-term contact lens wear. (17011862)
2006
18
Permanent corneal edema resulting from the treatment of PTK corneal haze with mitomycin: a case report. (15448508)
2004
19
Corneal edema resolution after "descemetorhexis". (12900257)
2003
20
A case of noninflammatory corneal edema following anterior-posterior radial keratotomy (Sato's operation) successfully treated by topical corticosteroid. (11033131)
2000
21
Effect of diclofenac sodium (Voltaren) on hypoxia-induced corneal edema in humans. (7712610)
1995
22
Corneal edema due to Asclepias curassavica. (7639668)
1995
23
Clinical and pathologic findings of aphakic peripheral corneal edema: Brown-McLean syndrome. (1468222)
1992
24
Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents. (1907950)
1991
25
Corneal edema after overnight lid closure of rabbits wearing silicone rubber contact lenses. (2019121)
1991
26
Loss of stromal glycosaminoglycans during corneal edema. (2210995)
1990
27
Results of anterior segment reconstruction for aphakic and pseudophakic corneal edema. (3211488)
1988
28
Corneal edema related to accidental Hibiclens exposure. (3400765)
1988
29
Acute corneal edema in pellucid marginal degeneration or acute marginal keratoconus. (3315452)
1987
30
Topical hyperosmolar solutions in the reduction of corneal edema. (3449294)
1987
31
Effect of soft lens power on peripheral corneal edema. (3740206)
1986
32
Fuchs' corneal dystrophy. A clinicopathologic study of the variation in corneal edema. (3526227)
1986
33
Peripheral corneal edema after cataract extraction. (4025488)
1985
34
Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses. (6592160)
1984
35
The minimum precorneal oxygen tension to avoid corneal edema. (6706510)
1984
36
Corneal edema as a result of ischemic endothelial damage: a case report. (7092039)
1982
37
Corneal edema. (7239818)
1981
38
Corneal edema with hydrogel lenses and eye closure: time course. (7212011)
1981
39
Temporal sequence study of the factors affecting corneal edema associated with soft contact lens wear. (7223850)
1981
40
Vision through an abnormal cornea: a pilot study of the relationship between visual loss from corneal distortion, corneal edema, keratoconus, and some allied corneal pathology. (437949)
1979
41
Acute unilateral central corneal edema. (910866)
1977
42
The effect of corneal edema on visual function. (832964)
1977
43
Anterior chamber scroll and corneal edema. (921153)
1977
44
Corneal edema: iris-clip lens implantation and simple intracapsular extraction compared. (904877)
1977
45
Persistent pupillary membranes and spontaneous corneal edema in a dog. (584602)
1977
46
Corneal edema from hard and hydrogel contact lenses. (1027791)
1976
47
Treatment of chronic corneal edema: summary. (5739741)
1968
48
Corneal edema from a cotton foreign body in the anterior chamber. (5642919)
1968
49
Corneal edema. (15418617)
1949
50
CORNEAL edema; unusual toxic reaction to atabrine. (21007548)
1946

Variations for Corneal Edema

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Expression for genes affiliated with Corneal Edema

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Search GEO for disease gene expression data for Corneal Edema.

Pathways for genes affiliated with Corneal Edema

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Pathways related to Corneal Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP1, MMP3
29.6MMP1, MMP3
39.1IL1B, MMP1, MMP3

Compounds for genes affiliated with Corneal Edema

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Compounds related to Corneal Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1uva 14510.0MMP3, MMP1
2ilomastat4510.0MMP3, MMP1
3latanoprost45 1311.0MMP1, MMP3
4nimesulide45 1311.0MMP1, MMP3
5(4-aminophenyl)mercuric acetate4510.0MMP1, MMP3
6thermolysin4510.0MMP1, MMP3
7uk 3833676110.0MMP3, MMP1
8gi 254023x6110.0MMP3, MMP1
9gm 60016110.0MMP3, MMP1
10sulfonamide4510.0MMP3, MMP1
11hydroxamate459.9MMP3, MMP1
12piroxicam45 1310.9IL1B, MMP3
13levonorgestrel45 61 30 1312.9MMP3, MMP1
14marimastat45 61 1311.9MMP1, MMP3
15clodronate45 51 1311.9MMP1, IL1B
16ethidium bromide459.9MMP3, MMP1
17alendronate45 51 1311.8MMP3, MMP1
18quinacrine45 1310.8MMP1, MMP3
19triptolide459.8MMP3, IL1B
20hematoxylin459.8MMP3, MMP1, KRT8
211,10-phenanthroline45 310.7MMP1, MMP3
22sulfasalazine30 45 51 1312.7MMP3, IL1B
23matrigel459.6KRT8, MMP1, MMP3
24alginate459.6IL1B, MMP3
25lxa4459.5IL1B, MMP1, MMP3
26leflunomide45 51 1311.5IL1B, MMP1, MMP3
27etanercept45 51 1311.5MMP3, MMP1, IL1B
28infliximab45 51 1311.5IL1B, MMP1, MMP3
29ibuprofen45 30 51 26 1313.5MMP3, MMP1, IL1B
30celecoxib45 61 30 51 26 1314.5IL1B, MMP1, MMP3
31pravastatin45 51 30 26 1313.5MMP3, MMP1, IL1B
32mifepristone45 30 61 1312.5IL1B, MMP1, MMP3
33troglitazone45 30 61 1312.5IL1B, MMP1, MMP3
34tgf beta1459.5MMP3, MMP1, IL1B
35ns 39845 6110.5IL1B, MMP1
36hyaluronic acid45 2610.5MMP3, MMP1, IL1B
37curcumin459.5IL1B, MMP1, MMP3
38prostaglandin459.5MMP3, MMP1, IL1B
39methotrexate51 45 1311.5IL1B, MMP1, MMP3
40rantes459.4MMP3, MMP1, IL1B
41ribonucleic acid459.4IL1B, MMP1, MMP3
42n acetylcysteine459.4MMP3, MMP1, IL1B
43indomethacin45 30 61 1312.4IL1B, MMP1, MMP3
44sb 20358045 6110.3MMP3, MMP1, IL1B
45ndga459.2IL1B, MMP3
46genistein45 30 61 3 26 1314.2MMP3, MMP1, IL1B, KRT8
47cycloheximide459.2KRT8, IL1B, MMP1, MMP3
48vegf459.1KRT8, IL1B, MMP1, MMP3
49pd 98,059459.1IL1B, MMP1, MMP3
50retinoic acid45 269.7MMP3, MMP1, IL1B, KRT8

GO Terms for genes affiliated with Corneal Edema

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Biological processes related to Corneal Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.6MMP1, MMP3

Products for genes affiliated with Corneal Edema

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Sources for Corneal Edema

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet