MCID: CRN026
MIFTS: 46

Corneal Edema malady

Eye diseases category

Summaries for Corneal Edema

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34MalaCards
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MalaCards: Corneal Edema, also known as corneal edema, unspecified, is related to keratoconus and posterior polymorphous corneal dystrophy. An important gene associated with Corneal Edema is KRT8 (keratin 8), and among its related pathways are Matrix Metalloproteinases and Cell adhesion Cell matrix glycoconjugates. The drugs sodium chloride and sodium chloride granules and the compounds ilomastat and uva 1 have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related mouse phenotypes are vision/eye and immune system.

Aliases & Classifications for Corneal Edema

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9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal edema 9 11 63
corneal edema, unspecified 9
unspecified corneal edema 9
corneal edema nos 9
corneal oedema 9
cornea edema 9


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Disease Ontology9 DOID:11030
ICD9CM28 371.20, 371.2
NCIt41 C50508
MeSH36 D015715

Related Diseases for Corneal Edema

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18GeneCards, 19GeneDecks
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Diseases related to Corneal Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconus30.5MMP1, FBXO7, VSX1, MMP3
2posterior polymorphous corneal dystrophy30.2VSX1
3corneal dystrophy30.1VSX1, SLC4A11, FBXO7
4keratopathy30.1FBXO7, PBK
5cataract10.7
6endotheliitis10.6
7glaucoma10.4
8idiopathic corneal edema10.4
9contact lens corneal edema10.3
10secondary corneal edema10.3
11uveitis10.3
12keratitis10.3
13hypoxia10.3
14retinitis10.2
15anterior uveitis10.2
16degenerative disc disease10.1IL1B
17interstitial keratitis10.1
18tularemia10.1
19periodontitis10.1IL1B
20irregular astigmatism10.1FBXO7, VSX1
21rubella10.0
22pearson syndrome10.0
23exophthalmos10.0
24recurrent corneal erosion10.0
25fuchs' endothelial dystrophy10.0
26cystoid macular edema10.0
27coloboma10.0
28bullous keratopathy10.0
29allergic conjunctivitis10.0
30conjunctivitis10.0
31diabetes mellitus10.0
32herpes simplex10.0
33keratoconjunctivitis10.0
34melanoma10.0
35neuropathy10.0
36retinal detachment10.0
37congenital rubella10.0
38pellucid marginal degeneration10.0
39glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.0
40corneal dystrophy, fuchs endothelial, 810.0
41stromal keratitis10.0
42essential iris atrophy10.0
43epidermolysis bullosa dystrophica10.0MMP3, MMP1
44conjunctivochalasis10.0MMP3, MMP1
45gingivitis10.0IL1B, MMP1
46abdominal aortic aneurysm10.0MMP1, MMP3
47basal cell carcinoma10.0KRT8, MMP3, MMP1
48pulmonary fibrosis10.0MMP1, KRT8, IL1B
49idiopathic pulmonary fibrosis10.0MMP1, IL1B
50fibrosarcoma10.0MMP3, MMP1, KRT8

Graphical network of the top 20 diseases related to Corneal Edema:



Diseases related to corneal edema

Symptoms for Corneal Edema

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Drugs & Therapeutics for Corneal Edema

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Corneal Edema

Drug clinical trials:

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Search CenterWatch for Corneal Edema

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Corneal Edema

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Anatomical Context for Corneal Edema

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34MalaCards
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MalaCards organs/tissues related to Corneal Edema:

34
Eye, Endothelial

Animal Models for Corneal Edema or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Corneal Edema:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6FBXO7, OVOL2, VSX1, SLC4A11
2MP:00053877.6FBXO7, MMP3, MMP1, PBK, IL1B, KRT8

Publications for Corneal Edema

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53PubMed
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Articles related to Corneal Edema:

(show top 50)    (show all 226)
idTitleAuthorsYear
1
Pseudophakic/aphakic corneal edema--morphometric predisposing factors analysis based on the fellow eye examination. (23461150)
2012
2
Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation. (21896863)
2011
3
Determinants of postoperative corneal edema and impact on goldmann intraocular pressure. (21505325)
2011
4
Is excimer laser corneal surgery appropriate after resolution of corneal edema in fuchs dystrophy by descemet membrane endothelial keratoplasty? (20540467)
2011
5
Amantadine-associated corneal edema treated with descemet's stripping automated endothelial keratoplasty. (21158374)
2010
6
Corneal graft detachment without corneal edema after descemet stripping automated endothelial keratoplasty. (20164759)
2010
7
Effect of incident light wavelength and corneal edema on light scattering and penetration: laboratory study of human corneas. (20954687)
2010
8
Amantadine-associated corneal edema. (19486806)
2009
9
Late corneal edema due to retained foldable lens fragment. (19384021)
2009
10
Reversible corneal edema associated with amantadine use: an unrecognized problem. (18785231)
2008
11
Corneal edema after aqueous drainage device implantation. (17571002)
2007
12
Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the Veterans Health Administration. (17893540)
2007
13
The effect of contact lens induced corneal edema on Goldmann applanation tonometry measurements. (17224766)
2007
14
Time to resolution of corneal edema after long-term contact lens wear. (17011862)
2006
15
Permanent corneal edema resulting from the treatment of PTK corneal haze with mitomycin: a case report. (15448508)
2004
16
Corneal edema resolution after "descemetorhexis". (12900257)
2003
17
A case of noninflammatory corneal edema following anterior-posterior radial keratotomy (Sato's operation) successfully treated by topical corticosteroid. (11033131)
2000
18
Effect of diclofenac sodium (Voltaren) on hypoxia-induced corneal edema in humans. (7712610)
1995
19
Corneal edema due to Asclepias curassavica. (7639668)
1995
20
Corneal edema after miochol. (8352312)
1993
21
Clinical and pathologic findings of aphakic peripheral corneal edema: Brown-McLean syndrome. (1468222)
1992
22
Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents. (1907950)
1991
23
Corneal edema after overnight lid closure of rabbits wearing silicone rubber contact lenses. (2019121)
1991
24
Phosphatic metabolism and corneal edema. (1889222)
1991
25
Loss of stromal glycosaminoglycans during corneal edema. (2210995)
1990
26
Results of anterior segment reconstruction for aphakic and pseudophakic corneal edema. (3211488)
1988
27
Corneal edema related to accidental Hibiclens exposure. (3400765)
1988
28
Acute corneal edema in pellucid marginal degeneration or acute marginal keratoconus. (3315452)
1987
29
Topical hyperosmolar solutions in the reduction of corneal edema. (3449294)
1987
30
Posterior chamber IOL implantation during keratoplasty for aphakic or pseudophakic corneal edema. (3319413)
1987
31
Effect of soft lens power on peripheral corneal edema. (3740206)
1986
32
Fuchs' corneal dystrophy. A clinicopathologic study of the variation in corneal edema. (3526227)
1986
33
Peripheral corneal edema after cataract extraction. (4025488)
1985
34
Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses. (6592160)
1984
35
The minimum precorneal oxygen tension to avoid corneal edema. (6706510)
1984
36
Corneal edema. (7239818)
1981
37
Corneal edema with hydrogel lenses and eye closure: time course. (7212011)
1981
38
Temporal sequence study of the factors affecting corneal edema associated with soft contact lens wear. (7223850)
1981
39
Vision through an abnormal cornea: a pilot study of the relationship between visual loss from corneal distortion, corneal edema, keratoconus, and some allied corneal pathology. (437949)
1979
40
Acute unilateral central corneal edema. (910866)
1977
41
The effect of corneal edema on visual function. (832964)
1977
42
Anterior chamber scroll and corneal edema. (921153)
1977
43
Corneal edema: iris-clip lens implantation and simple intracapsular extraction compared. (904877)
1977
44
Persistent pupillary membranes and spontaneous corneal edema in a dog. (584602)
1977
45
Corneal edema from hard and hydrogel contact lenses. (1027791)
1976
46
Treatment of chronic corneal edema: summary. (5739741)
1968
47
Corneal edema from a cotton foreign body in the anterior chamber. (5642919)
1968
48
The pathogenesis of corneal edema induced by Tween 80. (6064908)
1967
49
Corneal edema. (15418617)
1949
50
CORNEAL edema; unusual toxic reaction to atabrine. (21007548)
1946

Variations for Corneal Edema

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Expression for genes affiliated with Corneal Edema

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Edema

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Pathways for genes affiliated with Corneal Edema

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 61Thomson Reuters, 31KEGG
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Pathways related to Corneal Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP1, MMP3
29.6MMP1, MMP3
39.1IL1B, MMP1, MMP3

Compounds for genes affiliated with Corneal Edema

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 3BitterDB, 25HMDB
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Compounds related to Corneal Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1ilomastat4610.0MMP1, MMP3
2uva 14610.0MMP1, MMP3
3latanoprost46 1211.0MMP3, MMP1
4nimesulide46 1211.0MMP3, MMP1
5(4-aminophenyl)mercuric acetate4610.0MMP3, MMP1
6thermolysin4610.0MMP1, MMP3
7uk 3833676210.0MMP3, MMP1
8gm 60016210.0MMP1, MMP3
9gi 254023x6210.0MMP1, MMP3
10sulfonamide4610.0MMP3, MMP1
11levonorgestrel46 62 30 1212.9MMP3, MMP1
12piroxicam46 1210.9MMP3, IL1B
13hydroxamate469.9MMP1, MMP3
14marimastat46 62 1211.9MMP3, MMP1
15clodronate46 52 1211.9MMP1, IL1B
16ethidium bromide469.9MMP1, MMP3
17alendronate46 52 1211.8MMP1, MMP3
18quinacrine46 1210.8MMP3, MMP1
19hematoxylin469.7MMP3, MMP1, KRT8
20triptolide469.7MMP3, IL1B
211,10-phenanthroline46 310.7MMP1, MMP3
22sulfasalazine30 46 52 1212.7IL1B, MMP3
23matrigel469.6MMP3, MMP1, KRT8
24ns 39846 6210.6IL1B, MMP1
25alginate469.5MMP3, IL1B
26lxa4469.5IL1B, MMP1, MMP3
27leflunomide46 52 1211.5IL1B, MMP1, MMP3
28etanercept46 52 1211.5MMP3, IL1B, MMP1
29infliximab46 52 1211.5IL1B, MMP3, MMP1
30ibuprofen46 30 52 25 1213.5MMP3, IL1B, MMP1
31celecoxib46 62 30 52 25 1214.5MMP1, IL1B, MMP3
32pravastatin46 52 30 25 1213.5IL1B, MMP3, MMP1
33mifepristone46 30 62 1212.5IL1B, MMP1, MMP3
34troglitazone46 30 62 1212.5MMP1, IL1B, MMP3
35tgf beta1469.5MMP3, IL1B, MMP1
36hyaluronic acid46 2510.5MMP3, MMP1, IL1B
37curcumin469.5MMP3, IL1B, MMP1
38prostaglandin469.5IL1B, MMP1, MMP3
39methotrexate52 46 1211.5MMP3, IL1B, MMP1
40rantes469.4IL1B, MMP1, MMP3
41ribonucleic acid469.4MMP1, MMP3, IL1B
42n acetylcysteine469.4MMP1, MMP3, IL1B
43indomethacin46 30 62 1212.4MMP3, MMP1, IL1B
44sb 20358046 6210.3IL1B, MMP1, MMP3
45ndga469.2IL1B, MMP3
46genistein46 30 62 3 25 1214.2MMP3, MMP1, IL1B, KRT8
47cycloheximide469.2MMP3, MMP1, KRT8, IL1B
48vegf469.1MMP3, MMP1, IL1B, KRT8
49pd 98,059469.1MMP1, IL1B, MMP3
50retinoic acid46 259.7IL1B, MMP3, MMP1, KRT8

GO Terms for genes affiliated with Corneal Edema

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17Gene Ontology
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Biological processes related to Corneal Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:0305749.6MMP1, MMP3

Products for genes affiliated with Corneal Edema

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Sources for Corneal Edema

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet