MCID: CRN026
MIFTS: 46

Corneal Edema malady

Eye diseases category

Summaries for Corneal Edema

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MalaCards based summary: Corneal Edema, also known as unspecified corneal edema, is related to posterior polymorphous corneal dystrophy and corneal dystrophy. An important gene associated with Corneal Edema is KRT8 (keratin 8), and among its related pathways are Matrix Metalloproteinases and Cell adhesion Cell matrix glycoconjugates. The drugs sodium chloride and sodium chloride granules and the compounds ilomastat and uva 1 have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related mouse phenotypes are vision/eye and immune system.

Aliases & Classifications for Corneal Edema

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Corneal Edema, Aliases & Descriptions:

Name: Corneal Edema 9 11 61
Unspecified Corneal Edema 9 61
Corneal Edema, Unspecified 9
 
Corneal Edema Nos 9
Corneal Oedema 9
Cornea Edema 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:11030
MeSH34 D015715
ICD9CM28 371.20, 371.2
NCIt39 C50508

Related Diseases for Corneal Edema

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Diseases related to Corneal Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1posterior polymorphous corneal dystrophy30.7VSX1
2corneal dystrophy30.2SLC4A11, VSX1, FBXO7
3keratopathy30.2FBXO7, PBK
4keratoconus30.2FBXO7, MMP3, MMP1, VSX1
5cataract10.7
6endotheliitis10.6
7idiopathic corneal edema10.4
8secondary corneal edema10.3
9contact lens corneal edema10.3
10uveitis10.3
11degenerative disc disease10.3IL1B
12periodontitis10.3IL1B
13keratitis10.3
14hypoxia10.3
15irregular astigmatism10.3VSX1, FBXO7
16retinitis10.2
17anterior uveitis10.2
18interstitial keratitis10.1
19tularemia10.1
20diabetes mellitus10.0
21pearson syndrome10.0
22exophthalmos10.0
23cystoid macular edema10.0
24coloboma10.0
25rubella10.0
26recurrent corneal erosion10.0
27fuchs' endothelial dystrophy10.0
28bullous keratopathy10.0
29allergic conjunctivitis10.0
30conjunctivitis10.0
31herpes simplex10.0
32keratoconjunctivitis10.0
33melanoma10.0
34neuropathy10.0
35retinal detachment10.0
36congenital rubella10.0
37pellucid marginal degeneration10.0
38glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.0
39corneal dystrophy, fuchs endothelial, 610.0
40corneal dystrophy, fuchs endothelial, 810.0
41stromal keratitis10.0
42essential iris atrophy10.0
43epidermolysis bullosa dystrophica10.0MMP1, MMP3
44conjunctivochalasis10.0MMP1, MMP3
45gingivitis10.0MMP1, IL1B
46abdominal aortic aneurysm9.9MMP1, MMP3
47basal cell carcinoma9.9KRT8, MMP1, MMP3
48pulmonary fibrosis9.9MMP1, IL1B, KRT8
49idiopathic pulmonary fibrosis9.9MMP1, IL1B
50fibrosarcoma9.9KRT8, MMP1, MMP3

Graphical network of the top 20 diseases related to Corneal Edema:



Diseases related to corneal edema

Symptoms for Corneal Edema

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Drugs & Therapeutics for Corneal Edema

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Drug clinical trials:

Search ClinicalTrials for Corneal Edema

Search NIH Clinical Center for Corneal Edema

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Corneal Edema

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Anatomical Context for Corneal Edema

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MalaCards organs/tissues related to Corneal Edema:

32
Eye, Endothelial

Animal Models for Corneal Edema or affiliated genes

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MGI Mouse Phenotypes related to Corneal Edema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6SLC4A11, VSX1, OVOL2, FBXO7
2MP:00053877.6KRT8, FBXO7, MMP3, MMP1, PBK, IL1B

Publications for Corneal Edema

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Articles related to Corneal Edema:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
Acute corneal edema with subsequent thinning and hyperopic shift following selective laser trabeculoplasty. (25263043)
2014
2
Amantadine induced corneal edema in a patient with primary progressive freezing of gait. (24868424)
2013
3
Pseudophakic/aphakic corneal edema--morphometric predisposing factors analysis based on the fellow eye examination. (23461150)
2012
4
Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation. (21896863)
2011
5
Determinants of postoperative corneal edema and impact on goldmann intraocular pressure. (21505325)
2011
6
Is excimer laser corneal surgery appropriate after resolution of corneal edema in fuchs dystrophy by descemet membrane endothelial keratoplasty? (20540467)
2011
7
Amantadine-associated corneal edema treated with descemet's stripping automated endothelial keratoplasty. (21158374)
2010
8
Corneal graft detachment without corneal edema after descemet stripping automated endothelial keratoplasty. (20164759)
2010
9
Effect of incident light wavelength and corneal edema on light scattering and penetration: laboratory study of human corneas. (20954687)
2010
10
Amantadine-associated corneal edema. (19486806)
2009
11
Late corneal edema due to retained foldable lens fragment. (19384021)
2009
12
Reversible corneal edema associated with amantadine use: an unrecognized problem. (18785231)
2008
13
Corneal edema after aqueous drainage device implantation. (17571002)
2007
14
Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the Veterans Health Administration. (17893540)
2007
15
The effect of contact lens induced corneal edema on Goldmann applanation tonometry measurements. (17224766)
2007
16
Time to resolution of corneal edema after long-term contact lens wear. (17011862)
2006
17
Permanent corneal edema resulting from the treatment of PTK corneal haze with mitomycin: a case report. (15448508)
2004
18
Corneal edema resolution after "descemetorhexis". (12900257)
2003
19
A case of noninflammatory corneal edema following anterior-posterior radial keratotomy (Sato's operation) successfully treated by topical corticosteroid. (11033131)
2000
20
Effect of diclofenac sodium (Voltaren) on hypoxia-induced corneal edema in humans. (7712610)
1995
21
Corneal edema due to Asclepias curassavica. (7639668)
1995
22
Clinical and pathologic findings of aphakic peripheral corneal edema: Brown-McLean syndrome. (1468222)
1992
23
Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents. (1907950)
1991
24
Corneal edema after overnight lid closure of rabbits wearing silicone rubber contact lenses. (2019121)
1991
25
Phosphatic metabolism and corneal edema. (1889222)
1991
26
Loss of stromal glycosaminoglycans during corneal edema. (2210995)
1990
27
Results of anterior segment reconstruction for aphakic and pseudophakic corneal edema. (3211488)
1988
28
Corneal edema related to accidental Hibiclens exposure. (3400765)
1988
29
Acute corneal edema in pellucid marginal degeneration or acute marginal keratoconus. (3315452)
1987
30
Topical hyperosmolar solutions in the reduction of corneal edema. (3449294)
1987
31
Effect of soft lens power on peripheral corneal edema. (3740206)
1986
32
Fuchs' corneal dystrophy. A clinicopathologic study of the variation in corneal edema. (3526227)
1986
33
Peripheral corneal edema after cataract extraction. (4025488)
1985
34
Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses. (6592160)
1984
35
The minimum precorneal oxygen tension to avoid corneal edema. (6706510)
1984
36
Corneal edema as a result of ischemic endothelial damage: a case report. (7092039)
1982
37
Corneal edema. (7239818)
1981
38
Corneal edema with hydrogel lenses and eye closure: time course. (7212011)
1981
39
Temporal sequence study of the factors affecting corneal edema associated with soft contact lens wear. (7223850)
1981
40
Vision through an abnormal cornea: a pilot study of the relationship between visual loss from corneal distortion, corneal edema, keratoconus, and some allied corneal pathology. (437949)
1979
41
Acute unilateral central corneal edema. (910866)
1977
42
The effect of corneal edema on visual function. (832964)
1977
43
Anterior chamber scroll and corneal edema. (921153)
1977
44
Corneal edema: iris-clip lens implantation and simple intracapsular extraction compared. (904877)
1977
45
Persistent pupillary membranes and spontaneous corneal edema in a dog. (584602)
1977
46
Corneal edema from hard and hydrogel contact lenses. (1027791)
1976
47
Treatment of chronic corneal edema: summary. (5739741)
1968
48
Corneal edema from a cotton foreign body in the anterior chamber. (5642919)
1968
49
Corneal edema. (15418617)
1949
50
CORNEAL edema; unusual toxic reaction to atabrine. (21007548)
1946

Variations for Corneal Edema

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Expression for genes affiliated with Corneal Edema

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Expression patterns in normal tissues for genes affiliated with Corneal Edema

Search GEO for disease gene expression data for Corneal Edema.

Pathways for genes affiliated with Corneal Edema

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Pathways related to Corneal Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6MMP1, MMP3
29.6MMP1, MMP3
39.1IL1B, MMP1, MMP3

Compounds for genes affiliated with Corneal Edema

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Compounds related to Corneal Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1ilomastat4410.0MMP1, MMP3
2uva 14410.0MMP1, MMP3
3latanoprost44 1211.0MMP3, MMP1
4nimesulide44 1211.0MMP3, MMP1
5(4-aminophenyl)mercuric acetate4410.0MMP3, MMP1
6thermolysin4410.0MMP1, MMP3
7uk 3833676010.0MMP3, MMP1
8gm 60016010.0MMP1, MMP3
9gi 254023x6010.0MMP1, MMP3
10sulfonamide4410.0MMP3, MMP1
11levonorgestrel44 60 29 1212.9MMP3, MMP1
12piroxicam44 1210.9MMP3, IL1B
13hydroxamate449.9MMP1, MMP3
14marimastat44 60 1211.9MMP3, MMP1
15clodronate44 50 1211.9MMP1, IL1B
16ethidium bromide449.9MMP1, MMP3
17alendronate44 50 1211.8MMP1, MMP3
18quinacrine44 1210.8MMP3, MMP1
19hematoxylin449.7MMP3, MMP1, KRT8
20triptolide449.7MMP3, IL1B
211,10-phenanthroline44 310.7MMP1, MMP3
22sulfasalazine29 44 50 1212.7IL1B, MMP3
23matrigel449.6MMP3, MMP1, KRT8
24ns 39844 6010.6IL1B, MMP1
25alginate449.5MMP3, IL1B
26lxa4449.5IL1B, MMP1, MMP3
27leflunomide44 50 1211.5IL1B, MMP1, MMP3
28etanercept44 50 1211.5MMP3, IL1B, MMP1
29infliximab44 50 1211.5IL1B, MMP3, MMP1
30ibuprofen44 29 50 25 1213.5MMP3, IL1B, MMP1
31celecoxib44 60 29 50 25 1214.5MMP1, IL1B, MMP3
32pravastatin44 50 29 25 1213.5IL1B, MMP3, MMP1
33mifepristone44 29 60 1212.5IL1B, MMP1, MMP3
34troglitazone44 29 60 1212.5MMP1, IL1B, MMP3
35tgf beta1449.5MMP3, IL1B, MMP1
36hyaluronic acid44 2510.5MMP3, MMP1, IL1B
37curcumin449.5MMP3, IL1B, MMP1
38prostaglandin449.5IL1B, MMP1, MMP3
39methotrexate50 44 1211.5MMP3, IL1B, MMP1
40rantes449.4IL1B, MMP1, MMP3
41ribonucleic acid449.4MMP1, MMP3, IL1B
42n acetylcysteine449.4MMP1, MMP3, IL1B
43indomethacin44 29 60 1212.4MMP3, MMP1, IL1B
44sb 20358044 6010.3IL1B, MMP1, MMP3
45ndga449.2IL1B, MMP3
46genistein44 29 60 3 25 1214.2MMP3, MMP1, IL1B, KRT8
47cycloheximide449.2MMP3, MMP1, KRT8, IL1B
48vegf449.1MMP3, MMP1, IL1B, KRT8
49pd 98,059449.1MMP1, IL1B, MMP3
50retinoic acid44 259.7IL1B, MMP3, MMP1, KRT8

GO Terms for genes affiliated with Corneal Edema

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Biological processes related to Corneal Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:0305749.6MMP1, MMP3

Products for genes affiliated with Corneal Edema

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Sources for Corneal Edema

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet