MCID: CRN027
MIFTS: 47

Corneal Neovascularization malady

Eye diseases category
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Summaries for Corneal Neovascularization

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65Wikipedia, 33MalaCards
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Wikipedia:65 Corneal neovascularization is the excessive ingrowth of blood vessels from the limbal vascular plexus... more...

MalaCards: Corneal Neovascularization, also known as corneal neovascularization, unspecified, is related to endotheliitis and burns. An important gene associated with Corneal Neovascularization is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Dissolution of Fibrin Clot. The compounds epsilon aminocaproic acid and kininogen have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and brain, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Corneal Neovascularization

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8Disease Ontology, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal neovascularization 8 45 62
corneal neovascularization, unspecified 8
unspecified corneal neovascularization 8
corneal neovascularization nos 8


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Disease Ontology8 DOID:11382
MeSH35 D016510
ICD9CM27 370.6, 370.60
ICD1025 H16.4

Related Diseases for Corneal Neovascularization

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17GeneCards, 18GeneDecks
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Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1endotheliitis10.7
2burns10.6
3keratitis10.5
4limbal stem cell deficiency10.2
5keratopathy10.2
6hypoxia10.2
7stromal keratitis10.2
8diabetic macular edema10.1SERPINF1
9axenfeld-rieger syndrome10.1
10corneal dystrophy10.1
11herpes simplex10.1
12pterygium10.1
13retinitis10.1
14acanthamoeba keratitis10.1
15uveitis10.0SERPINF1, CXCL10
16retinal vascular disease10.0PLG, SERPINF1
17protein c deficiency10.0HRG, PLG
18thrombophilia10.0HRG, PLG
19thromboembolism10.0PLG, HRG
20hypersensitivity reaction type ii disease10.0CXCL10, PLG
21diabetic nephropathy10.0SERPINF1, PLG
22acute myocardial infarction10.0PLG, HRG
23kaposi's sarcoma10.0CXCL10, FGF2
24retinal degeneration10.0SERPINF1, FGF2
25idiopathic pulmonary fibrosis10.0FGF2, CXCL10
26vascular cancer10.0PLG, FGF2
27bladder carcinoma10.0FGF2, PLG
28pancreatic cancer10.0PLG, FGF2
29rheumatoid arthritis10.0HRG, CXCL10, PLG
30fibrosarcoma10.0FGF2, PLG
31proliferative diabetic retinopathy10.0SERPINF1, CXCL10, FGF2
32adenocarcinoma10.0PLG, CXCL10, SERPINF1
33brain cancer10.0PLG, FGF2
34diabetic retinopathy10.0FGF2, SERPINF1, PLG
35endometrial carcinoma9.9PLG, FGF2
36arthritis9.9FGF2, CXCL10, PLG
37hepatocellular carcinoma9.9FGF2, SERPINF1, PLG
38tongue squamous cell carcinoma9.9SERPINF1, FGF2, PLG
39malignant glioma9.9FGF2, PLG
40leukemia9.9FGF2, PLG, SERPINF1
41non-small cell lung carcinoma9.9SERPINF1, FGF2, PLG, CXCL10
42atherosclerosis9.9PLG, SERPINF1, FGF2, CXCL10
43melanoma9.9PLG, SERPINF1, CXCL10, FGF2
44prostate cancer9.9CXCL10, FGF2, PLG, SERPINF1
45breast cancer9.9CXCL10, PLG, SERPINF1, FGF2

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to corneal neovascularization

Symptoms for Corneal Neovascularization

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Drugs & Therapeutics for Corneal Neovascularization

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Corneal Neovascularization

Search NIH Clinical Center for Corneal Neovascularization

Genetic Tests for Corneal Neovascularization

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Anatomical Context for Corneal Neovascularization

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33MalaCards
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MalaCards organs/tissues related to Corneal Neovascularization:

33
Eye, Endothelial, Brain

Animal Models for Corneal Neovascularization or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Corneal Neovascularization:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6FGF2, PLG, SERPINF1
2MP:00053858.1FGF2, PLG, CXCL10, SERPINF1
3MP:00053978.0CXCL10, PLG, HRG, FGF2
4MP:00036318.0SERPINF1, CXCL10, PLG, FGF2
5MP:00053767.7FGF2, HRG, PLG, CXCL10

Publications for Corneal Neovascularization

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52PubMed
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Articles related to Corneal Neovascularization:

(show top 50)    (show all 327)
idTitleAuthorsYear
1
Inhibition of corneal neovascularization by subconjunctival and topical bevacizumab and sunitinib in a rabbit model. (24145627)
2013
2
The inhibitory effect of thalidomide analogue on corneal neovascularization in rabbits. (23739149)
2013
3
Corneal neovascularization: An enigma. (24379562)
2013
4
High-dose topical bevacizumab for corneal neovascularization. (24335191)
2013
5
The effect of different doses of subconjunctival bevacizumab injection on corneal neovascularization. (23404727)
2013
6
Vascular endothelial growth factor inhibitors for treatment of corneal neovascularization: a meta-analysis. (22668582)
2013
7
The association between corneal neovascularization and visual acuity: a systematic review. (22103683)
2013
8
Inhibition of Corneal Neovascularization with the Combination of Bevacizumab and Plasmid Pigment Epithelium-Derived Factor-Synthetic Amphiphile INTeraction-18 (p-PEDF-SAINT-18) Vector in a Rat Corneal Experimental Angiogenesis Model. (23591843)
2013
9
Anti-VEGF Therapy (Bevacizumab) for Sulfur Mustard-Induced Corneal Neovascularization Associated with Delayed Limbal Stem Cell Deficiency in Rabbits. (24215293)
2013
10
Minocycline inhibits alkali burn-induced corneal neovascularization in mice. (22848638)
2012
11
Corneal neovascularization: an anti-VEGF therapy review. (22898649)
2012
12
Preliminary studies of the effects of vascular adhesion protein-1 inhibitors on experimental corneal neovascularization. (21331460)
2011
13
(-)-Epigallocatechin 3-gallate (EGCG) at the ocular surface inhibits corneal neovascularization. (20971568)
2011
14
Prevention of corneal neovascularization: comparison of different doses of subconjunctival bevacizumab with its topical form in experimental rats. (21212709)
2011
15
The effect of doxycycline temperature-sensitive hydrogel on inhibiting the corneal neovascularization induced by BFGF in rats. (20953876)
2011
16
Features of corneal neovascularization and lymphangiogenesis induced by different etiological factors in mice. (20640436)
2011
17
Potential anti-angiogenic role of Slit2 in corneal neovascularization. (20298689)
2010
18
Inhibition of corneal neovascularization after alkali burn: comparison of different doses of bevacizumab in monotherapy or associated with dexamethasone. (21077280)
2010
19
The effect of bevacizumab on corneal neovascularization in rabbits. (20714387)
2010
20
Inhibition of corneal neovascularization by topical bevacizumab (Anti-VEGF) and Sunitinib (Anti-VEGF and Anti-PDGF) in an animal model. (20591397)
2010
21
A siRNA targeting vascular endothelial growth factor-A inhibiting experimental corneal neovascularization. (20450250)
2010
22
Inhibitory effects of bevacizumab on angiogenesis and corneal neovascularization. (18953554)
2009
23
Bevacizumab for corneal neovascularization. (19264217)
2009
24
Corneal neovascularization and ocular irritancy responses in dogs following topical ocular administration of an EP4-prostaglandin E2 agonist. (20008547)
2009
25
Combined use of superficial keratectomy and subconjunctival bevacizumab injection for corneal neovascularization. (18812781)
2008
26
Subconjunctival bevacizumab injection for corneal neovascularization in recurrent pterygium. (18214740)
2008
27
Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages. (18776949)
2008
28
The active metabolite of leflunomide A771726 inhibits corneal neovascularization. (18563344)
2008
29
Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization. (17198016)
2007
30
Alkali-induced corneal neovascularization is independent of CXCR2-mediated neutrophil infiltration. (17251813)
2007
31
The effect of combinations of flurbiprofen, low molecular weight heparin, and doxycycline on the inhibition of corneal neovascularization. (16783147)
2006
32
Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo. (15851564)
2005
33
Gene expression profile in corneal neovascularization identified by immunology related macroarray. (15547492)
2004
34
Experimental inhibition of corneal neovascularization by endostatin gene transfection in vivo. (14687476)
2003
35
Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice. (12506066)
2003
36
Suppression of corneal neovascularization by conditioned culture medium of human amniotic membrane]. (14769230)
2003
37
Angiostatin inhibits and regresses corneal neovascularization. (12149060)
2002
38
Lipid hydroperoxide induced corneal neovascularization in hyperglycemic rabbits. (12518243)
2002
39
Impact of short-term versus long-term topical steroids on corneal neovascularization after non-high-risk keratoplasty. (11521696)
2001
40
Photodynamic therapy for corneal neovascularization using topically administered ATX-S10 (Na). (10976562)
2000
41
Topically applied water extract of propolis to suppress corneal neovascularization in rabbits. (10474071)
1999
42
Photodynamic therapy for corneal neovascularization. (9793949)
1998
43
Treatment of corneal neovascularization with argon laser. (8230778)
1993
44
Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat. (2473047)
1989
45
Induction of conjunctival transdifferentiation on vascularized corneas by photothrombotic occlusion of corneal neovascularization. (2459642)
1988
46
Corneal neovascularization in contact lens wearers. (2419272)
1986
47
Corneal effect of isotretinoin: possible exacerbation of corneal neovascularization in a patient with the keratitis, ichthyosis, deafness ("KID") syndrome. (2419373)
1986
48
Experimental corneal neovascularization: biomicroscopic, angiographic, and morphologic correlation. (2419029)
1985-1986
49
The effects of leukocyte depletion on corneal neovascularization. (621924)
1978
50
Argon laser treatment of corneal neovascularization. (4582809)
1973

Variations for Corneal Neovascularization

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Expression for genes affiliated with Corneal Neovascularization

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for genes affiliated with Corneal Neovascularization

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Sources:
50PathCards, 55Reactome, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN
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Pathways related to Corneal Neovascularization according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3HRG, PLG
29.3HRG, PLG
3
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0FGF2, PLG
49.0FGF2, PLG
59.0FGF2, PLG
6
Show member pathways
8.6SERPINF1, PLG, FGF2

Compounds for genes affiliated with Corneal Neovascularization

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB, 29IUPHAR
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Compounds related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1epsilon aminocaproic acid459.7PLG, HRG
2kininogen459.6HRG, PLG
3dermatan sulfate459.4FGF2, HRG
4infliximab45 51 1111.4FGF2, CXCL10
5fumagillin45 61 1111.4FGF2, PLG
6alginate459.4FGF2, PLG
7nacl459.3HRG, PLG
8chondroitin sulfate45 2410.3FGF2, HRG
9gefitinib45 51 1111.3PLG, FGF2
10hydrocortisone45 3 61 1112.2FGF2, CXCL10
11thalidomide45 51 61 1112.2FGF2, PLG
12bromodeoxyuridine459.1FGF2, PLG
13glycosaminoglycan459.0FGF2, CXCL10, SERPINF1
14nitric oxide45 24 1111.0SERPINF1, CXCL10, PLG
15heparan sulfate45 249.9FGF2, HRG, CXCL10
16dexamethasone45 51 29 1111.9FGF2, CXCL10, SERPINF1
17suramin45 29 1110.9CXCL10, PLG, FGF2
18thymidine45 249.8FGF2, PLG, CXCL10
19cysteine458.8SERPINF1, PLG, HRG
20retinoic acid45 249.7FGF2, CXCL10, SERPINF1
21glucose458.6PLG, CXCL10, SERPINF1
22heparin45 29 24 1111.4SERPINF1, PLG, HRG, FGF2
23vegf458.4SERPINF1, CXCL10, PLG, FGF2
24serine458.4SERPINF1, PLG, HRG, FGF2
25tyrosine458.3SERPINF1, CXCL10, PLG, FGF2
26matrigel457.9FGF2, HRG, PLG, CXCL10, SERPINF1

GO Terms for genes affiliated with Corneal Neovascularization

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16Gene Ontology
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Cellular components related to Corneal Neovascularization according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.3HRG, PLG
2platelet alpha granule lumenGO:0310939.0HRG, PLG
3extracellular spaceGO:0056158.0SERPINF1, CXCL10, PLG, FGF2
4extracellular regionGO:0055767.5FGF2, HRG, PLG, CXCL10, SERPINF1

Biological processes related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.5HRG, PLG
2fibrinolysisGO:0427309.4PLG, HRG
3platelet activationGO:0301689.3HRG, PLG
4negative regulation of blood vessel endothelial cell migrationGO:0435379.2FGF2, HRG
5platelet degranulationGO:0025769.2PLG, HRG
6negative regulation of angiogenesisGO:0165259.2HRG, CXCL10, SERPINF1
7negative regulation of cell growthGO:0303088.8FGF2, HRG
8chemotaxisGO:0069358.8CXCL10, HRG, FGF2
9negative regulation of cell proliferationGO:0082858.5FGF2, HRG, PLG

Molecular functions related to Corneal Neovascularization according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.5HRG, SERPINF1
2heparin bindingGO:0082018.3FGF2, HRG, CXCL10

Products for genes affiliated with Corneal Neovascularization

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  • Antibodies
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Sources for Corneal Neovascularization

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet