MCID: CRN027
MIFTS: 55

Corneal Neovascularization malady

Eye diseases category

Summaries for Corneal Neovascularization

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63Wikipedia, 32MalaCards
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Wikipedia:63 Corneal neovascularization is the excessive ingrowth of blood vessels from the limbal vascular plexus... more...

MalaCards: Corneal Neovascularization, also known as corneal neovascularization, unspecified, is related to keratitis and herpes simplex. An important gene associated with Corneal Neovascularization is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are Cell adhesion Plasmin signaling and Integrins in angiogenesis. The compounds cycloheximide and suramin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and brain, and related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Corneal Neovascularization

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal neovascularization 8 44 60
corneal neovascularization, unspecified 8
unspecified corneal neovascularization 8
corneal neovascularization nos 8


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Disease Ontology8 DOID:11382
MeSH34 D016510
ICD9CM27 370.6, 370.60
ICD1025 H16.4

Related Diseases for Corneal Neovascularization

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17GeneCards, 18GeneDecks
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Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis30.6MMP2, FGF2, VEGFA
2herpes simplex30.0TIMP2, THBS1, CXCL10
3burns10.6
4limbal stem cell deficiency10.2
5corneal deposit10.2
6keratopathy10.2
7corneal disease10.0
8axenfeld-rieger syndrome10.0
9corneal granular dystrophy10.0
10corneal dystrophy10.0
11pterygium10.0
12retinitis10.0
13hypertension10.0PLG
14liver cirrhosis10.0PLG
15hemangioendothelioma10.0PLG
16synovitis10.0TIMP2
17pituitary adenoma10.0FGF2
18myopia 610.0SERPINF1
19hyperglycemia10.0SERPINF1
20moyamoya disease10.0FGF2
21biliary atresia10.0CXCL10
22pituitary tumors10.0FGF2
23retinal vein occlusion10.0VEGFA
24gastric ulcer10.0FGF2
25pneumonia10.0CXCL10
26disseminated intravascular coagulation10.0PF4
27antiphospholipid syndrome10.0PF4
28meningioma10.0FLT1
29hemorrhagic disease10.0PLG
30meningitis10.0CXCL10
31retinal ischemia10.0VEGFA
32rhabdomyosarcoma10.0FLT1
33cholangiocarcinoma10.0THBS1
34hepatitis b10.0CXCL10
35goiter10.0TEK
36pre-eclampsia10.0FLT1
37stroke, ischemic10.0PF4
38pulmonary emphysema10.0TIMP2
39retinal detachment10.0VEGFA, SERPINF1
40essential hypertension10.0PF4
41retinopathy of prematurity10.0FLT1, VEGFA
42laryngeal benign neoplasm10.0MMP2
43fibromatosis10.0TIMP2
44acute leukemia10.0CXCL12
45adenoma10.0THBS1, FLT1
46diabetic macular edema10.0VEGFA, SERPINF1
47age related macular degeneration10.0FLT1, VEGFA
48retinoblastoma10.0FLT1, SERPINF1
49protein c deficiency10.0PLG, HRG
50gingival overgrowth10.0CD36

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to corneal neovascularization

Clinical Features for Corneal Neovascularization

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Drugs & Therapeutics for Corneal Neovascularization

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Corneal Neovascularization

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Anatomical Context for Corneal Neovascularization

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32MalaCards
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MalaCards organs/tissues related to Corneal Neovascularization:

32
Endothelial, Eye, Brain

Animal Models for Corneal Neovascularization or affiliated genes

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36MGI
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Publications for Corneal Neovascularization

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50PubMed
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Articles related to Corneal Neovascularization:

(show top 50)    (show all 340)
idTitleAuthorsYear
1
The effect of topical doxycycline on corneal neovascularization. (23964705)
2014
2
The effect of different doses of subconjunctival bevacizumab injection on corneal neovascularization. (23404727)
2013
3
Anti-VEGF Therapy (Bevacizumab) for Sulfur Mustard-Induced Corneal Neovascularization Associated with Delayed Limbal Stem Cell Deficiency in Rabbits. (24215293)
2013
4
Inhibitory effects of topical cyclosporine A 0.05% on immune-mediated corneal neovascularization in rabbits. (24048578)
2013
5
Lack of association between VAP-1/SSAO activity and corneal neovascularization in a rabbit model. (23397320)
2013
6
Topical and subconjunctival ranibizumab (lucentis) for corneal neovascularization in experimental rat model. (23859535)
2013
7
The effect of topical bevacizumab as an adjunctive therapy for corneal neovascularization. (22998029)
2013
8
Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model. (23638411)
2013
9
Treatment of corneal neovascularization in ocular chemical injury with an off-label use of subconjunctival bevacizumab: a case report. (23889894)
2013
10
Photodynamic therapy with verteporfin for corneal neovascularization. (22623856)
2012
11
Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization. (23255672)
2012
12
Morphometric analysis of postoperative corneal neovascularization after high-risk keratoplasty: herpetic versus non-herpetic disease. (22419035)
2012
13
Preliminary studies of the effects of vascular adhesion protein-1 inhibitors on experimental corneal neovascularization. (21331460)
2011
14
Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization. (22072717)
2011
15
Inflammatory corneal neovascularization: etiopathogenesis. (21958169)
2011
16
New corneal neovascularization model in rabbits for angiogenesis research. (20847576)
2011
17
Drops for corneal neovascularization. (20888488)
2010
18
Inhibitory effects of bevacizumab on angiogenesis and corneal neovascularization. (18953554)
2009
19
Inhibitory effects of polysaccharide extract from Spirulina platensis on corneal neovascularization. (19784394)
2009
20
Bevacizumab (avastin) for corneal neovascularization--corneal light shield soaked application. (19158579)
2009
21
Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages. (18776949)
2008
22
The active metabolite of leflunomide A771726 inhibits corneal neovascularization. (18563344)
2008
23
Bevacizumab (Avastin) eye drops inhibit corneal neovascularization. (17934753)
2008
24
Inhibition of corneal neovascularization by subconjunctival bevacizumab in an animal model. (18207123)
2008
25
Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization. (17198016)
2007
26
Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo. (15851564)
2005
27
New drug delivery for corneal neovascularization using polyion complex micelles. (16227822)
2005
28
Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. (15326102)
2004
29
Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in the regulation of corneal neovascularization and wound healing. (15453853)
2004
30
Corneal neovascularization possibly associated with latanoprost therapy. (12635681)
2003
31
Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in inflammation-induced corneal neovascularization. (11721189)
2001
32
Leukocytes in the early events of corneal neovascularization. (11189012)
2001
33
Treatment parameters for selective occlusion of experimental corneal neovascularization by photodynamic therapy using a water soluble photosensitizer, ATX-S10(Na). (11133178)
2001
34
Effects of 1alpha,25-dihydroxyvitamin D3 on Langerhans cell migration and corneal neovascularization in mice. (10634615)
2000
35
Topically applied water extract of propolis to suppress corneal neovascularization in rabbits. (10474071)
1999
36
The heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization. (9733580)
1998
37
Photodynamic effect of a new photosensitizer ATX-S10 on corneal neovascularization. (9778412)
1998
38
Topical formulations of novel angiostatic steroids inhibit rabbit corneal neovascularization. (9331259)
1997
39
Corneal neovascularization after penetrating keratoplasty. (8575183)
1995
40
In vivo uptake of liposomal benzoporphyrin derivative and photothrombosis in experimental corneal neovascularization. (8569414)
1995
41
Effects of laser photocoagulation on corneal neovascularization in rabbits. (7719533)
1994
42
Acanthamoeba keratitis and corneal neovascularization. (7955293)
1994
43
Effectiveness of corneal neovascularization photothrombosis using phthalocyanine and a diode laser (675 nm). (8464305)
1993
44
Spontaneous corneal neovascularization in nude mice. (8225857)
1993
45
Hard contact lens-induced corneal neovascularization treated by oxygenation. (1716193)
1991
46
The effect of oxygen on corneal neovascularization. (1694835)
1990
47
Promotion of graft survival by photothrombotic occlusion of corneal neovascularization. (2478111)
1989
48
Induction of conjunctival transdifferentiation on vascularized corneas by photothrombotic occlusion of corneal neovascularization. (2459642)
1988
49
Pathology of anterior chamber angle in diabetic neovascular glaucoma: extension of corneal endothelium onto iris surface. (6190030)
1983
50
The effect of dexamethasone on corneal neovascularization induced by epidermal growth factor. (6166948)
1981

Genetic Variations for Corneal Neovascularization

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Expression for genes affiliated with Corneal Neovascularization

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for genes affiliated with Corneal Neovascularization

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 53Reactome, 51QIAGEN, 52R&D Systems, 49PharmGKB, 55SinoBiological
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Pathways related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PLG
210.3VEGFA
310.2FLT1
410.2KDR
510.2TEK
610.1PLG, HRG
79.8FLT1, VEGFA, KDR
89.8FLT1, VEGFA, KDR
9
Hide members
9.8KDR, VEGFA, FLT1
10
Hide members
9.8KDR, VEGFA, FLT1
11
Hide members
9.8KDR, VEGFA, FLT1
12
Hide members
9.8KDR, VEGFA, FLT1
13
Cell adhesion ECM remodeling
Hide members
9.8PLG, MMP2, TIMP2
149.7FLT1, KDR, TEK
15
Hide members
9.6HRG, PLG, THBS1, TEK
16
Hide members
9.6TIMP4, FKBP1A
179.6PF4, CXCL10, CXCL12
18
Hide members
9.6FLT1, VEGFA, FGF2, KDR
199.6THBS1, PLG, CXCL12, FGF2
20
Hide members
9.6TIMP2, TIMP4, CXCL12
21
Hide members
9.5MMP2, TIMP4, TIMP2
22
Hide members
9.5FLT1, VEGFA, KDR, THBS1
23
Development PDGF signaling via STATs and NF-kB
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9.5FGF2, MMP2, PLG, TEK
24
Transcription P53 signaling pathway
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9.4FLT1, VEGFA, MMP2, KDR
259.4VEGFA, FKBP1A, FGF2, THBS1
26
Hide members
9.3TIMP2, FGF2, MMP2, PLG, THBS1
27
Hide members
9.3FLT1, CXCL10, CXCL12, TEK, SERPINF1
289.3VEGFA, FGF2, MMP2, KDR, THBS1
29
Hide members
9.2TIMP2, FLT1, CXCL12, KDR, TEK
30
Hide members
9.1TIMP4, FLT1, FGF2, KDR, TEK
319.1TEK, KDR, FGF2, VEGFA, FLT1, TIMP2
329.1FLT1, VEGFA, FGF2, KDR, THBS1, TEK
339.0TIMP2, FLT1, FGF2, MMP2, KDR, TEK
34
Hide members
8.9VEGFA, CD36, PF4, HRG, PLG, THBS1
35
Hide members
8.9TIMP2, TIMP4, FLT1, FGF2, CXCL12, KDR
36
Hide members
8.6TEK, KDR, CXCL12, CXCL10, PF4, FLT1
37
Hide members
8.6TIMP2, TIMP4, FLT1, FGF2, CXCL12, KDR
38
Hide members
8.6TIMP2, TIMP4, FLT1, FGF2, CXCL12, KDR
39
Hide members
8.3TIMP2, TIMP4, FLT1, FGF2, CXCL12, MMP2
40
Hide members
8.3CD36, PF4, CXCL10, CXCL12, MMP2, PLG
41
Hide members
8.2TIMP2, TIMP4, FLT1, FGF2, CXCL12, MMP2
42
Hide members
8.0TIMP2, TIMP4, FLT1, PF4, FGF2, CXCL10
43
Hide members
8.0CXCL12, CXCL10, FGF2, PF4, FLT1, TIMP4
44
Hide members
7.8FLT1, VEGFA, FKBP1A, PF4, FGF2, CXCL10

Compounds for genes affiliated with Corneal Neovascularization

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB, 49PharmGKB
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Compounds related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.3CXCL10, CXCL12
2suramin44 28 1112.2KDR, PLG, CXCL10
3alginate4410.2CD36, PLG
4fumagillin44 59 1112.2PLG, FGF2, VEGFA
5su66684410.1FGF2, VEGFA, KDR
6carboxyamidotriazole4410.1VEGFA, MMP2, FGF2
7ptk7874410.1FLT1, VEGFA, KDR
8chondroitin sulfate44 2411.1HRG, THBS1, CD36
9pge24410.0MMP2, VEGFA, PF4
10zd6474449.9FLT1, VEGFA, KDR
11hydrocortisone44 2 59 1112.9KDR, MMP2, FGF2, FLT1
12axitinib44 59 1111.8FLT1, VEGFA, KDR
13paclitaxel44 49 1111.8THBS1, PLG, VEGFA, TIMP2, KDR
14tamoxifen44 49 28 1112.7THBS1, CXCL12, KDR, PLG
15gefitinib44 49 1111.7FGF2, MMP2, KDR, VEGFA, PLG
16dexamethasone44 49 28 1112.7VEGFA, FGF2, CXCL12, KDR, SERPINF1
17fucoidan449.6CXCL12, CD36, THBS1, KDR, FGF2
181,10-phenanthroline44 210.5MMP2, TIMP2, TIMP4, CXCL12
19infliximab44 49 1111.5CXCL10, TEK, VEGFA, FGF2
20thalidomide44 49 59 1112.5THBS1, CD36, VEGFA, PLG, FGF2, KDR
21dermatan sulfate449.4PF4, FGF2, HRG
22prostacyclin449.3THBS1, KDR, FGF2, PF4, VEGFA, FLT1
23cytochalasin d44 5910.3CD36, CXCL12, TIMP2, FGF2, MMP2, THBS1
24ribonucleic acid449.2TEK, TIMP2, FLT1, MMP2, CXCL12, THBS1
25fibrinogen449.2HRG, PF4, CXCL12, PLG, THBS1, TIMP2
26herbimycin a44 5910.2MMP2, CXCL12, FGF2, TIMP2, CD36
27heparan sulfate44 2410.2FGF2, THBS1, CXCL10, CXCL12, HRG, KDR
28oxygen44 2410.1TIMP2, FLT1, FKBP1A, PF4, TEK, SERPINF1
29hyaluronic acid44 2410.1THBS1, MMP2, CXCL12, VEGFA, FGF2, CD36
30matrigel449.1FLT1, TEK, THBS1, KDR, HRG, CXCL12
31tgf beta1448.9THBS1, CD36, MMP2, FLT1, PF4, FGF2
32nitric oxide44 11 2410.9SERPINF1, TEK, TIMP2, FLT1, CXCL10, THBS1
33glycosaminoglycan448.9CD36, PF4, SERPINF1, CXCL12, FGF2, CXCL10
34rapamycin448.9FLT1, FKBP1A, CXCL12, KDR, THBS1, VEGFA
35h2o2448.9FLT1, TIMP2, SERPINF1, THBS1, MMP2, FGF2
36sb 20358044 599.8THBS1, MMP2, CXCL12, FGF2, CD36, TIMP2
37wortmannin448.8PF4, CXCL10, KDR, CXCL12, MMP2, THBS1
38heparin44 28 11 2411.7SERPINF1, TIMP2, FLT1, VEGFA, CD36, PF4
395fluorouracil448.7PF4, KDR, MMP2, CXCL12, CD36, VEGFA
40paraffin448.6CD36, VEGFA, TEK, THBS1, KDR, MMP2
41thymidine44 249.5CXCL12, KDR, THBS1, TEK, TIMP2, FLT1
42serine448.4TIMP2, FGF2, FLT1, FKBP1A, PLG, HRG
43genistein44 28 59 2 11 2413.4FLT1, THBS1, KDR, MMP2, CXCL10, FGF2
44phosphatidylinositol448.4FLT1, FGF2, FKBP1A, CXCL10, KDR, CXCL12
45ly294002448.4KDR, THBS1, FGF2, MMP2, CXCL12, CD36
46cysteine448.3TIMP2, CD36, PF4, THBS1, KDR, HRG
47lipid448.1PF4, FLT1, FKBP1A, CXCL12, CXCL10, THBS1
48tyrosine448.0FLT1, TEK, SERPINF1, KDR, PLG, CXCL12
49calcium44 49 11 2410.5CXCL10, PF4, FLT1, CD36, PLG, TIMP2
50vegf447.1PF4, CD36, VEGFA, FLT1, TIMP2, FGF2

GO Terms for genes affiliated with Corneal Neovascularization

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16Gene Ontology
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Cellular components related to Corneal Neovascularization according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2VEGFA, PF4, HRG, PLG, THBS1
2cell surfaceGO:0099869.0TEK, THBS1, PLG, CD36, VEGFA, TIMP2
3external side of plasma membraneGO:0098978.2CD36, CXCL10, CXCL12, ROBO4, KDR, THBS1
4extracellular spaceGO:0056157.4PF4, VEGFA, FLT1, TIMP4, TIMP2, FGF2
5extracellular regionGO:0055767.0SERPINF1, TIMP2, TIMP4, VEGFA, PF4, FGF2

Biological processes related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1embryonic morphogenesisGO:04859810.3FGF2, FLT1
2negative regulation of fibrinolysisGO:05191810.3HRG, PLG, THBS1
3positive regulation of phospholipase C activityGO:01086310.3FLT1, FGF2
4negative regulation of blood vessel endothelial cell migrationGO:04353710.3THBS1, HRG, FGF2
5positive regulation of blood vessel endothelial cell migrationGO:04353610.2THBS1, FGF2, VEGFA
6positive regulation of intracellular protein kinase cascadeGO:01074010.2VEGFA, TEK
7cell migration involved in sprouting angiogenesisGO:00204210.2VEGFA, FGF2, KDR
8surfactant homeostasisGO:04312910.2KDR, VEGFA
9positive regulation of positive chemotaxisGO:05092710.2KDR, VEGFA
10cellular response to vascular endothelial growth factor stimulusGO:03592410.1KDR, VEGFA, FLT1
11positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.1TEK, FGF2, FLT1
12vascular endothelial growth factor receptor signaling pathwayGO:04801010.1KDR, VEGFA, FLT1
13sprouting angiogenesisGO:00204010.1FLT1, THBS1, TEK
14patterning of blood vesselsGO:00156910.0CXCL12, VEGFA, FLT1
15positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.0TEK, KDR, FLT1
16positive regulation of protein phosphorylationGO:00193410.0KDR, VEGFA
17peptidyl-tyrosine phosphorylationGO:01810810.0TEK, KDR, FLT1
18positive regulation of blood coagulationGO:03019410.0THBS1, CD36
19positive regulation of focal adhesion assemblyGO:05189410.0VEGFA, HRG, KDR, TEK
20negative regulation of endothelial cell apoptotic processGO:200035210.0TEK, KDR
21transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.0FLT1, KDR, TEK
22positive regulation of endothelial cell proliferationGO:0019389.9TEK, KDR, FGF2, VEGFA
23chemotaxisGO:0069359.9FGF2, CXCL10, CXCL12, HRG
24positive regulation of endothelial cell migrationGO:0105959.9VEGFA, KDR, THBS1, TEK
25extracellular matrix disassemblyGO:0226179.9TIMP2, MMP2, PLG
26positive regulation of cell migrationGO:0303359.9FLT1, VEGFA, KDR, THBS1
27positive regulation of MAPK cascadeGO:0434109.8TIMP2, FLT1, CD36, KDR
28extracellular matrix organizationGO:0301989.7TIMP2, FGF2, MMP2, PLG, THBS1
29positive regulation of cell proliferationGO:0082849.6FLT1, VEGFA, FGF2, CXCL10, KDR
30positive regulation of angiogenesisGO:0457669.5FLT1, VEGFA, FGF2, KDR, THBS1, TEK
31negative regulation of angiogenesisGO:0165259.5SERPINF1, TEK, THBS1, HRG, CXCL10, PF4
32positive regulation of ERK1 and ERK2 cascadeGO:0703749.5TEK, KDR, FGF2
33immune responseGO:0069559.4PF4, CXCL10, CXCL12, XBP1, THBS1
34platelet degranulationGO:0025769.4VEGFA, CD36, PF4, HRG, PLG, THBS1
35platelet activationGO:0301689.3VEGFA, CD36, PF4, HRG, PLG, THBS1
36response to drugGO:0424939.2TIMP2, TIMP4, XBP1, THBS1
37blood coagulationGO:0075969.1VEGFA, CD36, PF4, HRG, PLG, THBS1
38angiogenesisGO:0015259.0VEGFA, MMP2, HRG, ROBO4, KDR, TEK

Molecular functions related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:00502110.0KDR, FLT1
2metalloendopeptidase inhibitor activityGO:0081919.9TIMP4, TIMP2
3transmembrane receptor protein tyrosine kinase activityGO:0047149.8TEK, KDR, FLT1
4integrin bindingGO:0051789.7TIMP2, KDR, THBS1
5chemokine activityGO:0080099.7PF4, CXCL10, CXCL12
6transforming growth factor beta bindingGO:0504319.6THBS1, CD36
7heparin bindingGO:0082019.4THBS1, HRG, FGF2, PF4, VEGFA

Products for genes affiliated with Corneal Neovascularization

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  • Antibodies
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Sources for Corneal Neovascularization

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet