MCID: CRN027
MIFTS: 51

Corneal Neovascularization

Categories: Eye diseases

Aliases & Classifications for Corneal Neovascularization

MalaCards integrated aliases for Corneal Neovascularization:

Name: Corneal Neovascularization 12 28 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11382
ICD10 32 H16.4 H16.40
ICD9CM 34 370.6 370.60
MeSH 41 D016510
UMLS 69 C0085109

Summaries for Corneal Neovascularization

MalaCards based summary : Corneal Neovascularization is related to glomeruloid hemangioma and burns. An important gene associated with Corneal Neovascularization is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into... more...

Related Diseases for Corneal Neovascularization

Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 glomeruloid hemangioma 10.5 FLT1 VEGFA
2 burns 10.4
3 vitreous detachment 10.4 PLG VEGFA
4 critical limb ischemia 10.4 TEK VEGFA
5 skin hemangioma 10.4 KDR VEGFA
6 pyogenic granuloma 10.4 TEK VEGFA
7 angiodysplasia 10.4 FGF2 VEGFA
8 clivus chordoma 10.4 CXCL12 FGF2
9 endotheliitis 10.4
10 hemangioendothelioma 10.4 KDR PLG
11 cancer-associated retinopathy 10.3 FLT1 VEGFA
12 blood group, globoside system 10.3 PLG VEGFA
13 radiation proctitis 10.3 FGF2 KDR VEGFA
14 diabetic cataract 10.3 SERPINF1 VEGFA
15 angiokeratoma circumscriptum 10.3 FLT1 KDR VEGFA
16 bursitis 10.3 CXCL12 KDR
17 epithelioid hemangioendothelioma 10.3 FLT1 KDR VEGFA
18 angiomatous meningioma 10.3 FGF2 KDR VEGFA
19 lymphangioma 10.3 KDR SERPINF1 VEGFA
20 acute hemorrhagic leukoencephalitis 10.3 FLT1 KDR VEGFA
21 squamous cell carcinoma of the hypopharynx 10.3 TIMP2 VEGFA
22 vitreous disease 10.3 FGF2 PLG VEGFA
23 kuhnt-junius degeneration 10.3 KDR PLG VEGFA
24 macular retinal edema 10.2 CXCL12 SERPINF1 VEGFA
25 degeneration of macula and posterior pole 10.2 KDR PLG VEGFA
26 endophthalmitis 10.2 PLG VEGFA
27 keratitis, hereditary 10.2
28 placenta accreta 10.2 FLT1 KDR TEK
29 renal clear cell carcinoma 10.2 KDR TEK VEGFA
30 posterior uveal melanoma 10.2 THBS1 VEGFA
31 malignant glioma 10.2 FGF2 KDR VEGFA
32 kidney cancer 10.2 FGF2 KDR VEGFA
33 retinal vascular occlusion 10.2 PLG VEGFA
34 adenomyosis 10.1 TIMP2 VEGFA
35 microcystic meningioma 10.1 FLT1 TIMP2 VEGFA
36 lipodermatosclerosis 10.1 FLT1 TIMP2 VEGFA
37 dupuytren contracture 10.1 FGF2 TIMP2 VEGFA
38 breast carcinoma in situ 10.1 FGF2 FLT1 KDR VEGFA
39 diabetic macular edema 10.1 FGF2 SERPINF1 TEK VEGFA
40 renal cell carcinoma, nonpapillary 10.1 FGF2 FLT1 KDR VEGFA
41 capillary hemangioma 10.1 FLT1 KDR TEK VEGFA
42 chronic myocardial ischemia 10.1 FGF2 PLG TEK VEGFA
43 hemangioma 10.0 FGF2 KDR TEK VEGFA
44 placental insufficiency 10.0 FLT1 KDR TEK VEGFA
45 angiosarcoma 10.0 FLT1 KDR TEK VEGFA
46 exudative vitreoretinopathy 1 10.0 FLT1 KDR TEK VEGFA
47 odontogenic myxoma 10.0 CD36 VEGFA
48 stromal keratitis 10.0
49 pulmonary hypertension 10.0 FLT1 PLG TEK VEGFA
50 babesiosis 10.0 CD36 THBS1

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to Corneal Neovascularization

Symptoms & Phenotypes for Corneal Neovascularization

MGI Mouse Phenotypes related to Corneal Neovascularization:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 CD36 CXCL12 FGF2 FLT1 KDR PLG
2 hematopoietic system MP:0005397 10.26 SERPINF1 TEK THBS1 TIMP2 VEGFA XBP1
3 cellular MP:0005384 10.24 CD36 CXCL12 FGF2 FLT1 KDR PLG
4 homeostasis/metabolism MP:0005376 10.16 CD36 FGF2 FLT1 KDR PLG TEK
5 growth/size/body region MP:0005378 10.15 CD36 FLT1 KDR PLG SLIT2 TEK
6 immune system MP:0005387 10.13 CXCL12 FLT1 KDR PLG SERPINF1 THBS1
7 mortality/aging MP:0010768 10.11 FGF2 FLT1 KDR PLG SLIT2 TEK
8 digestive/alimentary MP:0005381 10.07 CD36 PLG SERPINF1 SLIT2 THBS1 VEGFA
9 endocrine/exocrine gland MP:0005379 10.05 CD36 PLG SERPINF1 SLIT2 THBS1 VEGFA
10 nervous system MP:0003631 10.03 CD36 CXCL12 FGF2 FLT1 KDR PLG
11 muscle MP:0005369 9.97 CD36 CXCL12 FGF2 FLT1 KDR TEK
12 liver/biliary system MP:0005370 9.95 CD36 CXCL12 KDR PLG THBS1 VEGFA
13 reproductive system MP:0005389 9.7 CXCL12 PLG SERPINF1 THBS1 VEGFA FGF2
14 skeleton MP:0005390 9.5 CD36 FGF2 KDR SERPINF1 THBS1 VEGFA
15 vision/eye MP:0005391 9.32 CD36 FGF2 FLT1 KDR PLG SERPINF1

Drugs & Therapeutics for Corneal Neovascularization

Drugs for Corneal Neovascularization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216974-75-3
2 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
3 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1
4 Antibodies Phase 4,Phase 2,Phase 1
5 Antibodies, Monoclonal Phase 4,Phase 2
6 Immunoglobulins Phase 4,Phase 2,Phase 1
7 Anesthetics Phase 4,Phase 2
8 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2
9
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
10
Oxytetracycline Approved, Investigational, Vet_approved Phase 2, Phase 3 79-57-2 5280972
11
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
12
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1 22916-47-8 4189
13
Natamycin Approved Phase 3 7681-93-8 5281099
14
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
15 Anti-Bacterial Agents Phase 2, Phase 3, Phase 1
16 Anti-Infective Agents Phase 2, Phase 3, Phase 1
17 Antimalarials Phase 2, Phase 3
18 Antiparasitic Agents Phase 2, Phase 3
19 Antiprotozoal Agents Phase 2, Phase 3
20 Endothelial Growth Factors Phase 2, Phase 3
21 Mitogens Phase 2, Phase 3
22 triamcinolone acetonide Phase 2, Phase 3
23 Triamcinolone diacetate Phase 2, Phase 3
24 Triamcinolone hexacetonide Phase 2, Phase 3
25 Hormone Antagonists Phase 3
26 Hormones Phase 3
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
28 Antifungal Agents Phase 3,Phase 1
29 Anti-Infective Agents, Local Phase 3
30 Cytochrome P-450 CYP3A Inhibitors Phase 3
31 Cytochrome P-450 Enzyme Inhibitors Phase 3
32 Steroid Synthesis Inhibitors Phase 3
33 Carboxymethylcellulose Sodium Phase 1, Phase 2
34 Cathartics Phase 1, Phase 2
35 Gastrointestinal Agents Phase 1, Phase 2
36 Laxatives Phase 1, Phase 2
37 Ophthalmic Solutions Phase 1, Phase 2
38 Tetrahydrozoline Phase 1, Phase 2
39 Antirheumatic Agents Phase 1, Phase 2
40 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
41
Ranibizumab Approved Phase 1 347396-82-1 459903
42
Betamethasone Approved, Vet_approved Phase 1 378-44-9 9782
43
Tropicamide Approved, Investigational Phase 1 1508-75-4 5593
44
Ephedrine Approved Phase 1 299-42-3 9294
45
Pseudoephedrine Approved Phase 1 90-82-4 7028
46
Zinc Approved, Investigational Phase 1 7440-66-6 32051 23994
47 Betamethasone benzoate Phase 1
48 Betamethasone sodium phosphate Phase 1
49 Betamethasone Valerate Phase 1 2152-44-5
50 Betamethasone-17,21-dipropionate Phase 1

Interventional clinical trials:

(show all 42)

# Name Status NCT ID Phase Drugs
1 The Effect of Bevacizumab on Corneal Neovascularization Completed NCT00797303 Phase 4 Bevacizumab
2 Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism Completed NCT01965288 Phase 4
3 Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency Recruiting NCT02577861 Phase 4
4 Strategies for Management of Corneal Neovascularisation Not yet recruiting NCT02594423 Phase 4 Bevacizumab
5 The Role of Amniotic Membrane Transplantation in Ocular Chemical Burns Unknown status NCT00370812 Phase 2, Phase 3
6 Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3 Doxycycline;Placebo
7 Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization Completed NCT00555594 Phase 2, Phase 3 Bevacizumab (Avastin)
8 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Enrolling by invitation NCT02731638 Phase 3 Intrastromal voriconazole;Natamycin
9 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2 Bevacizumab
10 Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose Unknown status NCT02157987 Phase 1, Phase 2 bevacuzimab spray
11 Treatment of Corneal Neovascularization With Topical Pazopanib Completed NCT01257750 Phase 1, Phase 2 Pazopanib (5mg/ml)
12 Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01072357 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
13 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
14 Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Cells of Sclerocorneal Limbus Amplified ex Vivo Completed NCT01470573 Phase 2
15 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Recruiting NCT01843101 Phase 2
16 A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Recruiting NCT01996826 Phase 1, Phase 2 Avastin® (bevacizumab);0.9% NaCl & Refresh Liquigel
17 Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial Recruiting NCT02318485 Phase 2
18 Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases Active, not recruiting NCT02739113 Phase 1, Phase 2
19 Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease Enrolling by invitation NCT03015779 Phase 1, Phase 2
20 Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization Not yet recruiting NCT02797704 Phase 1, Phase 2 Aflibercept
21 Topical IL-1-Ra for Treatment of Corneal Neovascularization Terminated NCT00915590 Phase 1, Phase 2 Placebo;IL-1Ra
22 Topical Avastin for Treatment of Corneal Neovascularization Completed NCT00559936 Phase 1 Topical Avastin 1%
23 Effectiveness and Safety of Topical Ranibizumab for Treatment of Corneal Neovascularization (NV) Completed NCT00681889 Phase 1 Ranibizumab
24 Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery Completed NCT00769145 Phase 1 Ranibizumab
25 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
26 Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1 Topical insulin eye drops;Conventional postoperative eye drops
27 Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea Terminated NCT01868360 Phase 1 Subconjunctival aflibercept
28 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
29 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
30 Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization Completed NCT00512876 Bevacizumab (Avastin)
31 Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization Completed NCT00004430 Dihematoporphyrin derivative;prednisolone
32 Photodynamic Therapy With Verteporfin for Corneal Neovascularization Completed NCT00471406
33 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603 subconjunctival injection of bevacizumab ( 1.25 to 2.50 mg)
34 Neovascularization Patterns in Corneal Graft Rejection Completed NCT01695655
35 Comparison of Subconjuctival Versus Topical Bevacizumab as Adjunct Therapy to Trabeculectomy Completed NCT01425112
36 Vistakon Investigational Lens Worn as a Single Use Daily Wear Completed NCT01031004
37 One Month Daily Wear Clinical Evaluation of New Prototype Contact Lenses in Habitual and Neophyte Contact Lens Wearers Completed NCT02081677
38 Assessment of Daily Disposable Silicone Hydrogel Lens Wear Completed NCT01093625
39 Evaluation of the CooperVision, Inc. Fanfilcon A and Enfilcon A Daily Wear Contact Lenses When Used for Frequent Replacement for up to One (1) Month of Daily Wear Completed NCT02555722
40 Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical Study Completed NCT02637804
41 Follow-up Study After ACLSCT for Restoration of Corneal Epithelium in Patients With LSCD Due to Ocular Burns Recruiting NCT03288844
42 Corneal Thinning During Topical Bevacizumab Therapy Withdrawn NCT00515684 bevacizumab (Avastin)

Search NIH Clinical Center for Corneal Neovascularization

Cochrane evidence based reviews: corneal neovascularization

Genetic Tests for Corneal Neovascularization

Genetic tests related to Corneal Neovascularization:

# Genetic test Affiliating Genes
1 Corneal Neovascularization 28

Anatomical Context for Corneal Neovascularization

MalaCards organs/tissues related to Corneal Neovascularization:

38
Eye, Endothelial, Neutrophil, Brain

Publications for Corneal Neovascularization

Articles related to Corneal Neovascularization:

(show top 50) (show all 443)
# Title Authors Year
1
Epithelium-derived miR-204 inhibits corneal neovascularization. ( 29246498 )
2018
2
Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization. ( 29445990 )
2018
3
Gene-based antiangiogenic applications for corneal neovascularization. ( 29080632 )
2018
4
MicroRNA-296 mediated corneal neovascularization in an animal model of corneal burns after alkali exposures. ( 29399058 )
2018
5
Critical Contact Lens Oxygen Transmissibility and Tear Lens Oxygen Tension to Preclude Corneal Neovascularization. ( 28799960 )
2017
6
Topical dimethyl sulfoxide inhibits corneal neovascularization and stimulates corneal repair in rabbits following acid burn. ( 29233043 )
2017
7
The inhibitory effect of different concentrations of KH902 eye drops on corneal neovascularization induced by alkali burn. ( 29133637 )
2017
8
Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P<sub>2</sub>X<sub>2</sub>. ( 29265937 )
2017
9
Evaluation of Corneal Neovascularization Using Optical Coherence Tomography Angiography in Patients With Limbal Stem Cell Deficiency. ( 28922332 )
2017
10
Effects of sunitinib and bevacizumab on VEGF and miRNA levels on corneal neovascularization. ( 28874077 )
2017
11
Inhibitory effects of S100A4 gene silencing on alkali burn-induced corneal neovascularization: an in vivo study. ( 28479848 )
2017
12
Effectiveness of photodynamic therapy with verteporfin combined with intrastromal bevacizumab for corneal neovascularization in Stevens-Johnson syndrome. ( 29256167 )
2017
13
Topical Timolol Inhibits Corneal Neovascularization in Rabbits. ( 29367933 )
2017
14
Topical versus subconjunctival anti-vascular endothelial growth factor therapy (Bevacizumab, Ranibizumab and Aflibercept) for treatment of corneal neovascularization. ( 28559722 )
2017
15
Therapeutic Potential of Ranibizumab in Corneal Neovascularization. ( 28606479 )
2017
16
Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization. ( 28393322 )
2017
17
Apatinib-loaded nanoparticles suppress vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization. ( 28740387 )
2017
18
Comparison of different doses of subconjunctival sunitinib with bevacizumab in the treatment of corneal neovascularization in experimental rats. ( 28458707 )
2017
19
Therapeutic approaches for corneal neovascularization. ( 29234686 )
2017
20
Growth inhibition of formed corneal neovascularization following Fosaprepitant treatment. ( 28205389 )
2017
21
Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization. ( 28115846 )
2017
22
Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis. ( 28055102 )
2017
23
Immunophysical analysis of corneal neovascularization: mechanistic insights and implications for pharmacotherapy. ( 28939878 )
2017
24
Corneal Neovascularization with Associated Lipid Keratopathy in a Patient with Obstructive Sleep Apnea-Hypopnea Syndrome Using a Continuous Positive Airway Pressure Machine. ( 28924439 )
2017
25
Combination of dexamethasone and Avastin(Ar) by supramolecular hydrogel attenuates the inflammatory corneal neovascularization in rat alkali burn model. ( 28800463 )
2017
26
Recent drug therapies for corneal neovascularization. ( 28489275 )
2017
27
Topical treatment of corneal alkali burns with Gly-thymosin I^4 solutions and in situ hydrogels via inhibiting corneal neovascularization and improving corneal epidermal recovery in experimental rabbits. ( 28602595 )
2017
28
Fibroblast growth factor-2 drives and maintains progressive corneal neovascularization following HSV-1 infection. ( 28378806 )
2017
29
Effect of Histone Deacetylase Inhibitor, Butyroyloxymethyl-Diethyl Phosphate (AN-7), on Corneal Neovascularization in a Mouse Model. ( 28338404 )
2017
30
Effects of topical and subconjunctival use of bevacizumab on corneal neovascularization in rabbits' eyes. ( 28954027 )
2017
31
Naringenin Eye Drops Inhibit Corneal Neovascularization by Anti-Inflammatory and Antioxidant Mechanisms. ( 29117277 )
2017
32
Suppression of corneal neovascularization by curcumin<i>via</i>inhibition of Wnt/I^-catenin pathway activation. ( 29259894 )
2017
33
Subconjunctival injection of antagomir-21 alleviates corneal neovascularization in a mouse model of alkali-burned cornea. ( 28052006 )
2016
34
Mapping Murine Corneal Neovascularization and Weight Loss Virulence Determinants in the Herpes Simplex Virus 1 Genome and the Detection of an Epistatic Interaction between the UL and IRS/US Regions. ( 27384650 )
2016
35
Comparison of Topical Low-Molecular-Weight Heparin-Taurocholate and Bevacizumab for Treatment and Prevention of Corneal Neovascularization. ( 27941385 )
2016
36
Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization. ( 27149536 )
2016
37
Inhibiting the effect of (90)Sr-(90)Y ophthalmic applicators on rat corneal neovascularization induced by sutures. ( 27672586 )
2016
38
Quantitative proteomic analysis of mice corneal tissues reveals angiogenesis-related proteins involved in corneal neovascularization. ( 27049463 )
2016
39
Efficacy of topical aflibercept versus topical bevacizumab for the prevention of corneal neovascularization in a rat model. ( 27020759 )
2016
40
Interleukin (IL)-17A Promotes Angiogenesis in an Experimental Corneal Neovascularization Model. ( 27419340 )
2016
41
Mesenchymal stem cells in corneal neovascularization: Comparison of different application routes. ( 27514011 )
2016
42
Therapeutic effects of a novel PIGF-1 derived peptide, ZY-1, on corneal neovascularization in vitro and in vivo. ( 27355331 )
2016
43
NADPH oxidase 2 plays a role in experimental corneal neovascularization. ( 26814205 )
2016
44
Reducible Polyethylenimine Nanoparticles for Efficient siRNA Delivery in Corneal Neovascularization Therapy. ( 27503770 )
2016
45
Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization. ( 27625050 )
2016
46
Intrastromal Injection of Bevacizumab in the Management of Corneal Neovascularization: About 25 Eyes. ( 27610242 )
2016
47
Assessment of therapeutic options for reducing alkali burn-induced corneal neovascularization and inflammation. ( 26651127 )
2016
48
Inhibitory effects of (90)Sr/(90)Y I^-irradiation on alkali burn-induced corneal neovascularization in rats. ( 26893623 )
2016
49
Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization. ( 27018842 )
2016
50
Effects of Combined Photodynamic Therapy and Topical Bevacizumab Treatment on Corneal Neovascularization in Rabbits. ( 27684458 )
2016

Variations for Corneal Neovascularization

Expression for Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for Corneal Neovascularization

Pathways related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 CXCL12 FGF2 FLT1 KDR TEK TIMP2
2
Show member pathways
13.29 CXCL12 FGF2 FLT1 KDR TEK TIMP2
3
Show member pathways
13.2 CXCL12 FGF2 FLT1 KDR TEK TIMP2
4
Show member pathways
13.19 CD36 HRG PLG TEK THBS1 VEGFA
5
Show member pathways
13.16 CXCL12 FGF2 FLT1 KDR TEK TIMP2
6
Show member pathways
13.12 CXCL12 FGF2 FLT1 KDR TEK TIMP2
7
Show member pathways
12.94 CXCL12 FGF2 FLT1 KDR TIMP2
8
Show member pathways
12.93 CXCL12 FGF2 FLT1 KDR TIMP2
9
Show member pathways
12.81 FGF2 FLT1 KDR TEK THBS1 VEGFA
10 12.64 FGF2 FLT1 KDR TEK VEGFA
11
Show member pathways
12.63 FGF2 KDR PLG THBS1 TIMP2
12
Show member pathways
12.57 CXCL12 FGF2 FLT1 KDR TIMP2
13
Show member pathways
12.52 FGF2 FLT1 KDR TEK THBS1 VEGFA
14
Show member pathways
12.28 FGF2 FLT1 KDR VEGFA
15 12.2 FGF2 KDR THBS1 VEGFA
16
Show member pathways
12.12 FGF2 FLT1 KDR VEGFA
17
Show member pathways
12.02 CD36 KDR THBS1
18 12 FGF2 FLT1 KDR TEK
19 11.96 FGF2 KDR VEGFA
20
Show member pathways
11.88 FLT1 KDR VEGFA
21 11.88 CD36 FGF2 VEGFA
22 11.79 FLT1 TEK VEGFA
23
Show member pathways
11.74 FLT1 KDR VEGFA
24 11.71 CXCL12 FLT1 TEK VEGFA
25 11.39 FGF2 KDR VEGFA
26 11.38 FGF2 FLT1 KDR TEK THBS1 TIMP2
27 11.36 FGF2 KDR PLG VEGFA
28 11.25 FGF2 FLT1 KDR VEGFA
29 11.2 FLT1 KDR VEGFA
30 11.05 CXCL12 FGF2 PLG THBS1
31 10.87 FGF2 FLT1 SLIT2 VEGFA
32 10.86 CXCL12 FGF2 FLT1 KDR TEK TIMP2
33
Show member pathways
10.81 FLT1 KDR VEGFA
34 10.73 HRG PLG
35 10.48 FGF2 FLT1 KDR TEK TIMP2 VEGFA

GO Terms for Corneal Neovascularization

Cellular components related to Corneal Neovascularization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.7 CD36 HRG PLG TEK THBS1 TIMP2
2 extracellular space GO:0005615 9.65 CD36 CXCL12 FGF2 FLT1 PLG SERPINF1
3 platelet alpha granule lumen GO:0031093 9.56 HRG PLG THBS1 VEGFA
4 extracellular region GO:0005576 9.4 CXCL12 FGF2 FLT1 HRG KDR PLG

Biological processes related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.94 CD36 KDR SERPINF1 VEGFA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 CD36 FGF2 KDR TEK
3 response to hypoxia GO:0001666 9.91 CXCL12 TEK THBS1 VEGFA
4 peptidyl-tyrosine phosphorylation GO:0018108 9.91 FGF2 FLT1 KDR TEK
5 chemotaxis GO:0006935 9.89 CXCL12 FGF2 FLT1 HRG SLIT2
6 positive regulation of protein phosphorylation GO:0001934 9.88 KDR TEK VEGFA
7 positive regulation of protein kinase B signaling GO:0051897 9.87 FGF2 TEK THBS1
8 negative regulation of endopeptidase activity GO:0010951 9.87 HRG SERPINF1 TIMP2
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.87 FLT1 KDR TEK
10 negative regulation of angiogenesis GO:0016525 9.85 HRG SERPINF1 TEK THBS1
11 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.84 FLT1 KDR VEGFA
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.83 FLT1 KDR TEK
13 positive regulation of MAPK cascade GO:0043410 9.83 CD36 FLT1 KDR TIMP2
14 platelet degranulation GO:0002576 9.83 CD36 HRG PLG THBS1 VEGFA
15 positive regulation of MAP kinase activity GO:0043406 9.82 FGF2 FLT1 VEGFA
16 positive regulation of cell migration GO:0030335 9.8 CXCL12 FLT1 KDR THBS1 VEGFA XBP1
17 positive regulation of endothelial cell migration GO:0010595 9.78 KDR TEK THBS1 VEGFA
18 positive chemotaxis GO:0050918 9.77 CXCL12 FGF2 VEGFA
19 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.75 FGF2 FLT1 TEK
20 negative regulation of blood vessel endothelial cell migration GO:0043537 9.74 FGF2 HRG THBS1
21 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.73 FLT1 KDR VEGFA
22 negative regulation of endothelial cell migration GO:0010596 9.71 SERPINF1 SLIT2 THBS1
23 positive regulation of blood vessel endothelial cell migration GO:0043536 9.71 FGF2 KDR THBS1 VEGFA
24 sprouting angiogenesis GO:0002040 9.7 TEK THBS1
25 fibrinolysis GO:0042730 9.7 HRG PLG
26 endothelial cell proliferation GO:0001935 9.69 TEK XBP1
27 negative regulation of fibrinolysis GO:0051918 9.69 HRG PLG THBS1
28 embryonic morphogenesis GO:0048598 9.68 FGF2 FLT1
29 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 FLT1 VEGFA
30 positive regulation of blood coagulation GO:0030194 9.68 CD36 THBS1
31 induction of positive chemotaxis GO:0050930 9.68 CXCL12 VEGFA
32 positive regulation of positive chemotaxis GO:0050927 9.67 KDR VEGFA
33 positive regulation of phospholipase C activity GO:0010863 9.67 FGF2 FLT1
34 vascular endothelial growth factor signaling pathway GO:0038084 9.67 FLT1 KDR
35 positive regulation of focal adhesion assembly GO:0051894 9.67 HRG KDR TEK VEGFA
36 positive regulation of axon extension involved in axon guidance GO:0048842 9.65 CXCL12 VEGFA
37 positive regulation of endothelial cell proliferation GO:0001938 9.65 CXCL12 FGF2 KDR TEK VEGFA
38 negative regulation of lamellipodium assembly GO:0010593 9.63 HRG SLIT2
39 regulation of cGMP metabolic process GO:0030823 9.62 THBS1 VEGFA
40 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.62 KDR VEGFA
41 negative regulation of endothelial cell chemotaxis GO:2001027 9.58 HRG THBS1
42 angiogenesis GO:0001525 9.5 FGF2 FLT1 HRG KDR TEK VEGFA
43 cell migration involved in sprouting angiogenesis GO:0002042 9.46 FGF2 KDR SLIT2 VEGFA
44 positive regulation of angiogenesis GO:0045766 9.17 FGF2 FLT1 KDR TEK THBS1 VEGFA
45 multicellular organism development GO:0007275 10.14 FGF2 FLT1 KDR SERPINF1 SLIT2 VEGFA
46 cell differentiation GO:0030154 10.12 FGF2 FLT1 KDR SLIT2 VEGFA XBP1
47 negative regulation of apoptotic process GO:0043066 10.06 KDR TEK THBS1 VEGFA XBP1
48 positive regulation of cell proliferation GO:0008284 10 CXCL12 FGF2 FLT1 KDR THBS1 VEGFA

Molecular functions related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.7 CXCL12 FGF2 VEGFA
2 integrin binding GO:0005178 9.63 KDR THBS1 TIMP2
3 protein tyrosine kinase activity GO:0004713 9.56 FGF2 FLT1 KDR TEK
4 fibronectin binding GO:0001968 9.51 THBS1 VEGFA
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 FLT1 KDR TEK
6 transforming growth factor beta binding GO:0050431 9.49 CD36 THBS1
7 low-density lipoprotein particle binding GO:0030169 9.43 CD36 THBS1
8 proteoglycan binding GO:0043394 9.4 SLIT2 THBS1
9 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 FLT1 KDR
10 growth factor binding GO:0019838 9.33 FLT1 KDR TEK
11 chemoattractant activity GO:0042056 9.13 CXCL12 FGF2 VEGFA
12 heparin binding GO:0008201 9.02 FGF2 HRG SLIT2 THBS1 VEGFA
13 protein binding GO:0005515 10.29 CD36 FGF2 FLT1 HRG KDR PLG

Sources for Corneal Neovascularization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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