Corneal Neovascularization malady

Wikipedia: Corneal neovascularization is the excessive ingrowth of blood vessels from the limbal vascular plexus...⁴⁴ more...

MalaCards: Corneal Neovascularization, also known as unspecified corneal neovascularization (disorder), is related to hypoxia and protein c deficiency. An important gene associated with Corneal Neovascularization is HRG (histidine-rich glycoprotein), and among its related pathways are Glioma Invasiveness and Actin-Based Motility by Rho Family GTPases. The compounds pge2 and fumagillin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Descriptions:

corneal neovascularization 6 32 43 unspecified corneal neovascularization (disorder) 6 corneal neovascularization nos (disorder) 6

corneal neovascularization, unspecified 6 corneal neovascularization (disorder) 6

Diseases related to corneal neovascularization by text searches and GeneDecks gene sharing:

(show top 50)    (show all 328)

id	Related Disease	Score	Top Affiliating Genes
1	hypoxia	23.6	SERPINF1, VEGFA, KDR, XBP1, CD36, MMP2
2	protein c deficiency	13.3	HRG, PLG, PF4
3	thromboembolism	13.3	HRG, PLG, PF4
4	diabetic macular edema	13.2	SERPINF1, VEGFA, FGF2
5	ocular melanoma	13.2	SERPINF1, VEGFA, PLG
6	arteriovenous malformation	13.2	KDR, FLT1, TEK
7	intermittent claudication	13.2	FGF2, TEK, PF4
8	congenital nephrotic syndrome finnish type	13.2	VEGFA, KDR
9	proliferative vitreoretinopathy	13.2	FGF2, TIMP2, THBS1
10	maxillary sinus squamous cell carcinoma	13.2	VEGFA, FGF2
11	leukostasis	13.2	SERPINF1, VEGFA, KDR
12	thrombophilia	13.2	HRG, PLG, PF4
13	factor vii deficiency	13.1	VEGFA, FGF2, THBS1
14	cluttering	13.1	MMP2, CXCL10
15	cavernous hemangioma of face	13.1	XBP1, FGF2, TEK
16	capillary hemangioma	13.1	VEGFA, KDR, TEK
17	inflammatory breast cancer	13.1	FLT1, FGF2, TEK
18	rosacea	13.1	VEGFA, KDR, FLT1
19	hemangiopericytoma	13.1	VEGFA, KDR, FGF2
20	ectopic pregnancy	13.0	VEGFA, FLT1, TIMP2
21	kidney cancer	13.0	VEGFA, KDR, FGF2
22	myeloproliferative disorder	13.0	KDR, FGF2, PF4
23	chronic myocardial ischemia	13.0	VEGFA, FGF2, TEK, PLG
24	ovarian hyperstimulation syndrome	13.0	VEGFA, KDR, FLT1
25	retinal hemangioblastoma	13.0	VEGFA, CXCL12
26	retinal vascular disease	13.0	SERPINF1, VEGFA, KDR, PLG
27	tongue cancer	13.0	MMP2, FLT1
28	skin carcinoma	13.0	MMP2, PLG, THBS1
29	intraocular melanoma	12.9	MMP2, PLG, THBS1
30	hereditary leiomyomatosis and renal cell cancer	12.9	VEGFA, FGF2, THBS1
31	critical limb ischemia	12.9	VEGFA, FGF2, TEK, THBS1
32	bursitis	12.9	KDR, CXCL12
33	duodenal ulcer	12.9	FGF2, PLG, TIMP2
34	cerebral infarction	12.9	VEGFA, FGF2, PLG, PF4
35	factor v leiden thrombophilia	12.9	FLT1, PLG, PF4, THBS1
36	macular retinal edema	12.9	SERPINF1, VEGFA, CXCL12
37	osteogenesis imperfecta type iii	12.9	SERPINF1, CD36
38	aneurysm disease	12.9	MMP2, PLG, TIMP2
39	primary effusion lymphoma	12.9	VEGFA, XBP1, FGF2
40	idiopathic pulmonary fibrosis	12.9	MMP2, FGF2, TIMP4
41	hydrops of gallbladder	12.9	SERPINF1, VEGFA, KDR, FLT1
42	cystoid macular edema	12.9	VEGFA, CXCL10, CXCL12
43	testicular germ cell tumor	12.9	VEGFA, FLT1, FGF2, THBS1
44	pilocytic astrocytoma	12.8	VEGFA, KDR, FLT1, THBS1
45	prostate disease	12.8	FGF2, THBS1, CXCL12
46	lymphangioleiomyomatosis	12.8	VEGFA, MMP2, FGF2
47	retinal ischemia	12.8	VEGFA, FGF2, CXCL12
48	refractive error	12.8	MMP2, TIMP2, TIMP4
49	anaplastic meningioma	12.8	VEGFA, KDR, MMP2
50	myxoid liposarcoma of the ovary	12.8	VEGFA, FLT1, CXCL12

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to corneal neovascularization:

²²

MGI Mouse Phenotypes related to corneal neovascularization:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.8	HRG, FGF2, XBP1
2	immune system phenotype	MP:0005387	9.2	CXCL10, THBS1, PLG, FLT1, KDR
3	growth/size phenotype	MP:0005378	8.9	XBP1, FKBP1A, TEK, PLG, THBS1
4	liver/biliary system phenotype	MP:0005370	8.2	PLG, FKBP1A, CD36, XBP1, VEGFA
5	mortality/aging	MP:0010768	7.5	TIMP4, PLG, TEK, FKBP1A, FLT1, CD36
6	vision/eye phenotype	MP:0005391	7.3	THBS1, PLG, FGF2, FLT1, MMP2, CD36
7	muscle phenotype	MP:0005369	6.7	THBS1, TEK, FGF2, FKBP1A, FLT1, MMP2
8	cellular phenotype	MP:0005384	6.2	TEK, PLG, THBS1, CXCL10, CXCL12, FGF2
9	nervous system phenotype	MP:0003631	5.4	CXCL12, CXCL10, TIMP2, PLG, TEK, FGF2
10	homeostasis/metabolism phenotype	MP:0005376	5.2	TEK, PLG, PF4, TIMP2, TIMP4, THBS1
11	cardiovascular system phenotype	MP:0005385	5.1	SERPINF1, CXCL12, CXCL10, THBS1, TIMP4, PLG

Articles related to corneal neovascularization:

(show all 23)

id	Title	Authors	Year	Affiliating Genes
1	A siRNA targeting vascular endothelial growth factor- A inhibiting experimental corneal neovascularization. (20450250)	Zuo L.... Xu X.	2010	VEGFA
2	Inhibitory effects of polysaccharide extract from Spi rulina platensis on corneal neovascularization. (19784394)	Yang L.... Xie L.	2009	MMP2, SERPINF1, CXCL12
3	Emerging roles for the CD36 scavenger receptor as a p otential therapeutic target for corneal neovascularization. (19075779)	Mwaikambo B.R.... Hardy P.	2008	CD36
4	Inhibitory effect of curcumin on corneal neovascularization in vitro and in vivo. (18497527)	Bian F.... Zhu Y.	2008	VEGFA
5	Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization. (17198016)	Singh N.... Ambati B.K.	2007	VEGFA
6	A synthetic peptide selected by bioinformatics inhib its mouse corneal neovascularization (17459247)	Zhao H.... Xu X.	2007	VEGFA
7	Inhibition of corneal neovascularization with a nutrient mixture containing lysine, proline, ascorbic acid, and green tea extract. (17845900)	Shakiba Y.... Mostafaie A.	2007	VEGFA
8	Inhibition of corneal neovascularization by recombina nt adenovirus-mediated sFlk-1 expression. (17692288)	Yu H.... Huang Q.	2007	FLT1, VEGFA
9	Flt-1 intraceptor induces the unfolded protein response, apoptotic factors, and regression of murine injury-induced corneal neovascularization. (17065489)	Singh N.... Ambati B.K.	2006	XBP1
10	Inhibition of corneal neovascularization by rapamycin. (16672771)	Kwon Y.S.... Kim J.C.	2006	FGF2, VEGFA
11	Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo. (15851564)	Singh N.... Ambati B.K.	2005	VEGFA
12	Inhibitory effect of rapamycin on corneal neovascular ization in vitro and in vivo. (15671269)	Kwon Y.S.... Son Y.	2005	FLT1, VEGFA, FKBP1A
13	Corneal neovascularization suppressed by TIMP2 released from human amniotic membranes. (17162918)	Ma X.... Li J.	2005	FGF2, TIMP2
14	Suppression of corneal neovascularization by PEDF release from human amniotic membranes. (15161837)	Shao C.... Ma J.X.	2004	SERPINF1
15	Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. (15326102)	Ma X.... Bazan N.G.	2004	VEGFA
16	Suppression of corneal neovascularization by conditioned culture medium of human amniotic membrane (14769230)	Ma X.... Li J.	2003	FGF2
17	Expression of tissue inhibitor of metalloproteinase-4 in normal human corneal cells and experimental corneal neovascularization. (12815195)	Ma D.H.... Tsai R.J.	2003	TIMP4
18	Suppression of corneal neovascularization by culture supernatant of human amniotic cells. (11805510)	Kobayashi N.... Homma Y.	2002	FGF2
19	Inhibition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA. (12470964)	Lai C.M.... Rakoczy P.E.	2002	VEGFA
20	Corneal neovascularization. (11507336)	Chang J.H.... Azar D.T.	2001	PLG, SERPINF1
21	Diurnal variations in angiostatin in human tear fluid: a possible role in prevention of corneal neovascularization. (10342373)	Sack R.A.... Sathe S.	1999	PLG
22	Tecogalan sodium inhibits corneal neovascularization induced by basic fibroblast growth factor. (8927305)	Murata T.... Inomata H.	1995	FGF2
23	Recombinant human epidermal growth factor and corneal neovascularization. (1289616)	Nezu E.... Manabe R.	1992	FGF2

Genes related to corneal neovascularization according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	HRG	histidine-rich glycoprotein	11.0
2	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
3	PLG	plasminogen	11.0	Publications
4	TEK	TEK tyrosine kinase, endothelial	11.0
5	THBS1	thrombospondin 1	11.0
6	PF4	platelet factor 4	11.0
7	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
8	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
9	CXCL10	chemokine (C-X-C motif) ligand 10	11.0
10	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
11	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0
12	VEGFA	vascular endothelial growth factor A	11.0	Publications
13	TIMP4	TIMP metallopeptidase inhibitor 4	11.0	Publications
14	XBP1	X-box binding protein 1	11.0	Publications
15	FKBP1A	FK506 binding protein 1A, 12kDa	11.0	Publications
16	ABLIM1	actin binding LIM protein 1	11.0
17	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
18	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
19	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications

Pathways related to corneal neovascularization according to GeneDecks:

(show top 50)    (show all 75)

id	Pathway	Score	Top Affiliating Genes
1	Glioma Invasiveness36	10.4	PLG, FGF2
2	Actin-Based Motility by Rho Family GTPases36	10.4	TIMP4
3	Breast Cancer Regulation by Stathmin136	9.9	FGF2, TEK, TIMP4
4	Neurophilin interactions with VEGF and VEGFR38	9.8	VEGFA, KDR, FLT1
5	CREB Pathway36	9.8	KDR, TIMP4
6	14-3-3 Induced Intracellular Signaling36	9.7	TIMP4, TEK, FGF2, FLT1
7	eNOS Signaling36	9.4	CXCL12, TIMP4, TIMP2, TEK
8	eIF2 Pathway36	9.2	CXCL12, TIMP4, TIMP2, FGF2
9	Akt Signaling36	9.2	CXCL12, CXCL10, TIMP4, PF4, TEK
10	Endothelin-1 Signaling Pathway36	9.0	CXCL12, CXCL10, PF4, TEK, FLT1
11	PPAR Pathway36	9.0	CXCL12, TIMP4, TIMP2, FGF2, FLT1
12	Apoptotic Pathways in Synovial Fibroblasts36	8.8	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
13	JNK Pathway36	8.7	CXCL12, TIMP4, TEK, FGF2, FLT1, KDR
14	p53 Mediated Apoptosis36	8.7	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
15	Angiogenesis3	8.7	TIMP2, TEK, FGF2, FLT1, MMP2, KDR
16	Telomerase Components in Cell Signaling36	8.7	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
17	Mitochondrial Apoptosis36	8.7	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
18	NF-KappaB (p50-p65) Pathway36	8.7	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
19	NF-KappaB Family Pathway36	8.7	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
20	ERK5 Signaling36	8.7	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
21	Cellular Apoptosis Pathway36	8.7	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
22	ERK Signaling36	8.6	CXCL12, CXCL10, TIMP4, TIMP2, PF4, TEK
23	Nuclear Receptor Activation by Vitamin-A36	8.6	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
24	Rac1 Pathway36	8.6	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
25	p70S6K Signaling36	8.6	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
26	DHA Signaling36	8.6	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
27	IP3 Pathway36	8.6	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
28	Molecular Mechanisms of Cancer36	8.5	CXCL12, TIMP4, TIMP2, PF4, TEK, FGF2
29	Nanog in Mammalian ESC Pluripotency36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
30	Paxillin Interactions36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
31	Ras Pathway36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
32	NFAT in Immune Response36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
33	Estrogen Pathway36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
34	Activation of PKC through GPCR36	8.5	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
35	GPCR Pathway36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
36	GSK3 Signaling36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
37	JAK-STAT Pathway36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
38	Activation of PKA through GPCR36	8.5	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
39	Renin-Angiotensin Pathway36	8.4	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
40	Intracellular Calcium Signaling36	8.4	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
41	TGF-Beta Pathway36	8.4	CXCL12, TIMP4, TIMP2, FGF2, FLT1, KDR
42	ILK Signaling36	8.3	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
43	Cytokine-cytokine receptor interaction20	8.3	CXCL12, CXCL10, PF4, FLT1, KDR, VEGFA
44	PAK Pathway36	8.2	CXCL12, CXCL10, TIMP4, TIMP2, PF4, FGF2
45	MAPK Signaling36	8.1	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
46	Antioxidant Action of Vitamin-C36	8.0	CXCL12, CXCL10, TIMP4, TIMP2, PF4, TEK
47	p38 Signaling36	8.0	CXCL12, CXCL10, TIMP4, TIMP2, PF4, TEK
48	Rho Family GTPases36	8.0	CXCL12, CXCL10, TIMP4, TIMP2, PF4, TEK
49	Activation of cAMP-Dependent PKA36	7.8	CXCL12, TIMP4, TIMP2, TEK, FGF2, FLT1
50	Pancreatic Adenocarcinoma36	7.7	KDR, CXCL12, TIMP4, TIMP2, TEK, FGF2

Compounds related to corneal neovascularization according to GeneDecks:

(show top 50)    (show all 121)

id	Compound	Score	Top Affiliating Genes
1	pge232	10.0	PF4, FGF2, CXCL10
2	fumagillin32 42 9 9	12.9	PLG, FGF2, VEGFA
3	axitinib32 42	10.9	VEGFA, FLT1, KDR
4	su 541642	9.9	VEGFA, KDR, FLT1
5	ptk78732	9.8	KDR, FLT1, VEGFA
6	su666832	9.8	VEGFA, KDR, FGF2
7	zd647432	9.7	FLT1, KDR, VEGFA
8	fibrinogen32	9.5	PLG, TIMP2, PF4, THBS1, HRG
9	carboxyamidotriazole32	9.4	FGF2, MMP2, VEGFA
10	chondroitin sulfate32 18	10.3	HRG, CD36, PF4, THBS1, FGF2
11	infliximab32 9 9	11.2	CXCL10, TEK, VEGFA, FGF2
12	oxygen32 18	10.2	SERPINF1, FLT1, FKBP1A, TEK, PF4, THBS1
13	suramin32 9 9	11.2	VEGFA, KDR, FGF2, PLG, PF4, CXCL10
14	prostacyclin32	9.1	VEGFA, PF4, FLT1, FGF2, THBS1, KDR
15	rapamycin32 42	10.1	VEGFA, FKBP1A, FLT1, KDR
16	thalidomide32 42 9 9	12.0	PLG, FGF2, THBS1, KDR, VEGFA, CD36
17	hyaluronic acid32 18	10.0	CD36, TIMP2, FGF2, CXCL12, THBS1
18	paclitaxel32 34 9 9	11.9	PLG, VEGFA, KDR, FLT1, FGF2, TIMP2
19	dermatan sulfate32	8.9	CD36, PF4, HRG, FGF2
20	fucoidan32	8.9	CXCL12, THBS1, KDR, CD36, FGF2
21	alginate32	8.8	CD36, FGF2, MMP2, PLG
22	gefitinib32 34 9 9	11.8	PLG, FGF2, VEGFA, MMP2, KDR
23	tamoxifen32 34 9 9	11.7	VEGFA, CXCL12, PLG, TIMP2, THBS1, KDR
24	heparan sulfate32 18	9.7	KDR, FGF2, HRG, PF4, THBS1, CXCL10
25	1,10-phenanthroline32	8.6	TIMP4, TIMP2, MMP2, CXCL12
26	nitric oxide32 9 18 9	11.6	CXCL10, THBS1, TIMP2, TEK, FLT1, KDR
27	ly29400232	8.5	MMP2, TIMP2, FGF2, THBS1, VEGFA, FKBP1A
28	cysteine32	8.4	SERPINF1, KDR, MMP2, HRG, TEK, PF4
29	hydrocortisone32 9 9	10.4	CXCL10, FGF2, MMP2, KDR, CD36, FLT1
30	ribonucleic acid32	8.3	THBS1, MMP2, CXCL12, FLT1, TIMP2, TEK
31	glycosaminoglycan32	8.3	PF4, FGF2, CD36, THBS1, CXCL10, CXCL12
32	tgf beta132	8.2	CD36, FGF2, KDR, MMP2, FLT1, THBS1
33	cytochalasin d32 42	9.1	THBS1, TIMP2, FGF2, MMP2, CD36, CXCL12
34	herbimycin a32 42	9.0	CXCL12, TIMP2, FGF2, MMP2, CD36
35	thymidine32 18	9.0	KDR, TIMP2, CXCL10, THBS1, PF4, PLG
36	dexamethasone32 42 34 9 9	11.9	CXCL10, CXCL12, FGF2, CD36, KDR, SERPINF1
37	paraffin32	7.6	MMP2, TIMP2, VEGFA, TEK, FGF2, FLT1
38	5fluorouracil32	7.5	THBS1, CXCL12, MMP2, CD36, KDR, VEGFA
39	sb 20358032 42	8.5	CXCL12, THBS1, TIMP2, FLT1, FGF2, CD36
40	lipid32	7.5	PLG, FKBP1A, FLT1, PF4, XBP1, THBS1
41	cycloheximide32	7.5	CXCL12, CXCL10, FGF2, THBS1, MMP2, CD36
42	phosphatidylinositol32	7.3	CXCL10, KDR, TEK, MMP2, FLT1, FKBP1A
43	heparin32 9 18 9	10.2	FGF2, CD36, KDR, VEGFA, SERPINF1, HRG
44	genistein32 9 18 9	9.9	VEGFA, MMP2, CXCL10, THBS1, TIMP2, FGF2
45	serine32	6.3	FKBP1A, HRG, FLT1, MMP2, KDR, SERPINF1
46	calcium32 9 18 9	9.3	THBS1, CXCL10, SERPINF1, CD36, XBP1, CXCL12
47	estrogen32	6.2	CXCL12, KDR, MMP2, XBP1, TIMP2, VEGFA
48	tyrosine32	6.1	CXCL10, FGF2, PF4, PLG, CXCL12, FLT1
49	matrigel32	6.1	TEK, CD36, CXCL10, KDR, VEGFA, SERPINF1
50	vegf32	5.7	XBP1, CXCL12, CXCL10, THBS1, CD36, MMP2

Cellular components related to corneal neovascularization according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.0	THBS1, PF4, PLG, HRG, VEGFA
2	external side of plasma membrane	GO:009897	8.5	KDR, CD36, THBS1, CXCL10, CXCL12
3	extracellular space	GO:005615	6.5	CXCL12, CXCL10, THBS1, TIMP4, PF4, PLG
4	extracellular region	GO:005576	5.9	SERPINF1, CXCL12, CXCL10, THBS1, TIMP4, TIMP2

Biological processes related to corneal neovascularization according to GeneDecks:

(show all 36)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of fibrinolysis	GO:051918	10.2	THBS1, PLG, HRG
2	embryonic morphogenesis	GO:048598	10.2	FGF2, FLT1
3	positive regulation of intracellular protein kinase cascade	GO:010740	10.1	TEK, VEGFA
4	sprouting angiogenesis	GO:002040	10.1	THBS1, TEK, FLT1
5	negative regulation of blood vessel endothelial cell migration	GO:043537	10.1	THBS1, HRG, FGF2
6	positive regulation of phospholipase C activity	GO:010863	10.1	FLT1, FGF2
7	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.0	TEK, FGF2, FLT1
8	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.0	KDR, FLT1, TEK
9	positive regulation of blood vessel endothelial cell migration	GO:043536	9.9	THBS1, FGF2, VEGFA
10	negative regulation of endothelial cell apoptotic process	GO:2000352	9.9	TEK, KDR
11	cellular response to vascular endothelial growth factor stimulus	GO:035924	9.9	FLT1, KDR, VEGFA
12	vascular endothelial growth factor receptor signaling pathway	GO:048010	9.9	VEGFA, KDR, FLT1
13	positive regulation of positive chemotaxis	GO:050927	9.9	VEGFA, KDR
14	peptidyl-tyrosine phosphorylation	GO:018108	9.9	KDR, FLT1, TEK
15	cell migration involved in sprouting angiogenesis	GO:002042	9.9	FGF2, KDR, VEGFA
16	heart trabecula formation	GO:060347	9.8	FKBP1A, TEK
17	positive regulation of focal adhesion assembly	GO:051894	9.8	VEGFA, KDR, HRG, TEK
18	transmembrane receptor protein tyrosine kinase signaling pathway	GO:007169	9.8	KDR, FLT1, TEK
19	positive regulation of endothelial cell migration	GO:010595	9.8	VEGFA, KDR, TEK, THBS1
20	positive regulation of cell migration	GO:030335	9.6	VEGFA, KDR, FLT1, THBS1
21	positive regulation of blood coagulation	GO:030194	9.6	CD36, THBS1
22	negative regulation of angiogenesis	GO:016525	9.5	SERPINF1, HRG, TEK, PF4, THBS1, CXCL10
23	positive regulation of MAPK cascade	GO:043410	9.5	FLT1, CD36, KDR
24	extracellular matrix disassembly	GO:022617	9.5	MMP2, PLG, TIMP2
25	chemotaxis	GO:006935	9.4	CXCL12, CXCL10, HRG, FGF2
26	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.3	KDR, FGF2, TEK
27	response to hypoxia	GO:001666	9.3	VEGFA, FLT1, THBS1, CXCL12
28	positive regulation of cell proliferation	GO:008284	9.2	VEGFA, KDR, FLT1, FGF2, CXCL10
29	positive regulation of angiogenesis	GO:045766	9.2	THBS1, TEK, FGF2, FLT1, KDR, VEGFA
30	platelet degranulation	GO:002576	9.1	THBS1, PF4, PLG, HRG, CD36, VEGFA
31	platelet activation	GO:030168	9.1	THBS1, PF4, PLG, HRG, CD36, VEGFA
32	positive regulation of endothelial cell proliferation	GO:001938	9.1	CXCL12, TEK, FGF2, KDR, VEGFA
33	immune response	GO:006955	8.9	CXCL12, CXCL10, THBS1, PF4, XBP1
34	angiogenesis	GO:001525	8.9	TEK, HRG, MMP2, KDR, VEGFA
35	blood coagulation	GO:007596	8.9	THBS1, PF4, PLG, TEK, HRG, CD36
36	negative regulation of apoptotic process	GO:043066	8.9	CXCL12, THBS1, PF4, TEK, KDR, VEGFA

Molecular functions related to corneal neovascularization according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor-activated receptor activity	GO:005021	9.9	KDR, FLT1
2	cell surface binding	GO:043498	9.9	PLG, HRG, VEGFA
3	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.8	KDR, FLT1, TEK
4	transforming growth factor beta binding	GO:050431	9.7	CD36, THBS1
5	integrin binding	GO:005178	9.6	THBS1, TIMP2, KDR
6	metalloendopeptidase inhibitor activity	GO:008191	9.5	TIMP2, TIMP4
7	chemokine activity	GO:008009	9.4	CXCL12, CXCL10, PF4
8	heparin binding	GO:008201	9.3	VEGFA, FGF2, HRG, PF4, THBS1