MCID: CRN027
MIFTS: 47

Corneal Neovascularization malady

Categories: Eye diseases

Aliases & Classifications for Corneal Neovascularization

Aliases & Descriptions for Corneal Neovascularization:

Name: Corneal Neovascularization 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11382
ICD10 33 H16.4 H16.40
ICD9CM 35 370.6 370.60
MeSH 42 D016510
UMLS 69 C0085109

Summaries for Corneal Neovascularization

MalaCards based summary : Corneal Neovascularization is related to burns and endotheliitis. An important gene associated with Corneal Neovascularization is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Ranibizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are cardiovascular system and cellular

Wikipedia : 71 Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into... more...

Related Diseases for Corneal Neovascularization

Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Related Disease Score Top Affiliating Genes
1 burns 10.3
2 endotheliitis 10.3
3 laryngeal adenoid cystic carcinoma 10.2 FLT1 VEGFA
4 degenerative disc disease 10.2 TEK VEGFA
5 kidney osteogenic sarcoma 10.2 FLT1 KDR VEGFA
6 pyriform sinus cancer 10.2 FGF2 SERPINF1 VEGFA
7 benign idiopathic neonatal seizures 10.2 FGF2 KDR VEGFA
8 neuropathy with hearing impairment 10.2 FLT1 KDR VEGFA
9 benign familial neonatal epilepsy 10.2 KDR SERPINF1 VEGFA
10 ovarian disease 10.2 FLT1 KDR VEGFA
11 anterograde amnesia 10.2 FGF2 SERPINF1 VEGFA
12 neurilemmoma of the pleura 10.2 FGF2 KDR VEGFA
13 hand, foot and mouth disease 10.2 KDR PLG VEGFA
14 immature teratoma of ovary 10.1 CXCL12 FGF2
15 upper respiratory tract disease 10.1 FGF2 PLG VEGFA
16 vesiculobullous skin disease 10.1 KDR TEK VEGFA
17 metagonimiasis 10.1 FGF2 KDR VEGFA
18 keratitis 10.1
19 multilocular clear cell renal cell carcinoma 10.1 CXCL12 SERPINF1 VEGFA
20 hemiplegic migraine 10.1 KDR PLG
21 neuropathy, hereditary sensory, type ib 10.1 FGF2 KDR VEGFA
22 radiation induced angiosarcoma of the breast 10.1 TEK VEGFA
23 pulmonary blastoma 10.1 FLT1 KDR TEK
24 saethre-chotzen syndrome 10.1 FGF2 KDR VEGFA
25 cone-rod dystrophy 17 10.1 KDR VEGFA
26 thymus adenosquamous carcinoma 10.0 FLT1 KDR SERPINF1 VEGFA
27 craniosynostosis, type 1 10.0 THBS1 VEGFA
28 common variable immunodeficiency 10.0 FGF2 PLG TEK VEGFA
29 vulvitis 10.0 FLT1 KDR TEK VEGFA
30 human granulocytic anaplasmosis 10.0 FLT1 KDR TEK VEGFA
31 grade iii astrocytoma 10.0 FGF2 KDR VEGFA
32 breast apocrine carcinoma 10.0 THBS1 VEGFA
33 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 10.0 FGF2 FLT1 KDR SERPINF1 VEGFA
34 vernal conjunctivitis 9.9 FLT1 KDR PLG SERPINF1 VEGFA
35 stromal keratitis 9.9
36 epidermolysis bullosa simplex, sutosomal recessive 2 9.9 CXCL12 FGF2 FLT1 SERPINF1 VEGFA
37 albinism, oculocutaneous, type ib 9.9 FLT1 KDR SERPINF1 TEK VEGFA
38 hemolytic anemia 9.9 FGF2 FLT1 KDR TEK VEGFA
39 pituitary infarct 9.9 TEK THBS1 VEGFA
40 oppositional defiant disorder 9.9 CXCL12 FGF2 KDR TEK VEGFA
41 mucinous ovarian cystadenoma 9.9 CXCL12 FGF2 KDR TEK VEGFA
42 citrullinemia, type ii, neonatal-onset 9.8 FGF2 FLT1 KDR SERPINF1 TEK VEGFA
43 keratopathy 9.8
44 limbal stem cell deficiency 9.8
45 herpes simplex 9.8
46 hypoxia 9.8
47 mitral valve stenosis 9.8 FGF2 FLT1 KDR THBS1 VEGFA
48 thrombosis 9.6
49 ichthyosis 9.6
50 corneal dystrophy 9.6

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to Corneal Neovascularization

Symptoms & Phenotypes for Corneal Neovascularization

MGI Mouse Phenotypes related to Corneal Neovascularization:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.33 CD36 CXCL12 FGF2 FLT1 KDR PLG
2 cellular MP:0005384 10.24 CD36 CXCL12 FGF2 FLT1 KDR PLG
3 hematopoietic system MP:0005397 10.22 CD36 CXCL12 FGF2 FLT1 KDR PLG
4 growth/size/body region MP:0005378 10.15 XBP1 CD36 FLT1 KDR PLG SLIT2
5 homeostasis/metabolism MP:0005376 10.11 VEGFA XBP1 CD36 FGF2 FLT1 KDR
6 mortality/aging MP:0010768 10.11 TEK THBS1 VEGFA XBP1 CD36 CXCL12
7 immune system MP:0005387 10.09 CD36 CXCL12 FLT1 KDR PLG SERPINF1
8 digestive/alimentary MP:0005381 10.07 CD36 PLG SERPINF1 SLIT2 THBS1 VEGFA
9 endocrine/exocrine gland MP:0005379 10.05 CD36 PLG SERPINF1 SLIT2 THBS1 VEGFA
10 nervous system MP:0003631 10 CD36 CXCL12 FGF2 FLT1 KDR PLG
11 muscle MP:0005369 9.97 FGF2 FLT1 KDR TEK THBS1 VEGFA
12 liver/biliary system MP:0005370 9.95 CD36 CXCL12 KDR PLG THBS1 VEGFA
13 reproductive system MP:0005389 9.7 CXCL12 FGF2 FLT1 PLG SERPINF1 THBS1
14 skeleton MP:0005390 9.5 CD36 FGF2 KDR SERPINF1 THBS1 VEGFA
15 vision/eye MP:0005391 9.32 CD36 FGF2 FLT1 KDR PLG SERPINF1

Drugs & Therapeutics for Corneal Neovascularization

Drugs for Corneal Neovascularization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 1 347396-82-1 459903
2
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
3 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
4 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
5 Antibodies Phase 4,Phase 2,Phase 1
6 Antibodies, Monoclonal Phase 4,Phase 2
7 Immunoglobulins Phase 4,Phase 2,Phase 1
8 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
9 Anesthetics Phase 4,Phase 2
10
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
11
Oxytetracycline Approved, Vet_approved Phase 2, Phase 3 79-57-2 5280972
12
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
13
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1 22916-47-8 4189
14
Natamycin Approved Phase 3 7681-93-8 5281099
15
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
16 Anti-Bacterial Agents Phase 2, Phase 3, Phase 1
17 Anti-Infective Agents Phase 2, Phase 3, Phase 1
18 Antimalarials Phase 2, Phase 3
19 Antiparasitic Agents Phase 2, Phase 3
20 Antiprotozoal Agents Phase 2, Phase 3
21 Endothelial Growth Factors Phase 2, Phase 3
22 Mitogens Phase 2, Phase 3
23 triamcinolone acetonide Phase 2, Phase 3
24 Triamcinolone diacetate Phase 2, Phase 3
25 Triamcinolone hexacetonide Phase 2, Phase 3
26 Hormone Antagonists Phase 3
27 Hormones Phase 3
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
29 Antifungal Agents Phase 3,Phase 1
30 Anti-Infective Agents, Local Phase 3
31 Cytochrome P-450 CYP3A Inhibitors Phase 3
32 Cytochrome P-450 Enzyme Inhibitors Phase 3
33 Steroid Synthesis Inhibitors Phase 3
34
Ephedrine Approved Phase 1, Phase 2 299-42-3 9294
35
Pseudoephedrine Approved Phase 1, Phase 2 90-82-4 7028
36 Carboxymethylcellulose Sodium Phase 1, Phase 2
37 Cathartics Phase 1, Phase 2
38 Gastrointestinal Agents Phase 1, Phase 2
39 Laxatives Phase 1, Phase 2
40 Autonomic Agents Phase 1, Phase 2
41 Lubricant Eye Drops Phase 1, Phase 2
42 Nasal Decongestants Phase 1, Phase 2
43 Ophthalmic Solutions Phase 1, Phase 2
44 Peripheral Nervous System Agents Phase 1, Phase 2
45 Respiratory System Agents Phase 1, Phase 2
46 Tetrahydrozoline Phase 1, Phase 2
47 Vasoconstrictor Agents Phase 1, Phase 2
48 Adrenergic Agents Phase 1, Phase 2
49 Adrenergic Agonists Phase 1, Phase 2
50 Adrenergic alpha-2 Receptor Agonists Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 56)
id Name Status NCT ID Phase
1 Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of Lucentis Unknown status NCT01669447 Phase 4
2 The Effect of Bevacizumab on Corneal Neovascularization Completed NCT00797303 Phase 4
3 Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism Completed NCT01965288 Phase 4
4 Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency Recruiting NCT02577861 Phase 4
5 Strategies for Management of Corneal Neovascularisation Not yet recruiting NCT02594423 Phase 4
6 The Role of Amniotic Membrane Transplantation in Ocular Chemical Burns Unknown status NCT00370812 Phase 2, Phase 3
7 Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3
8 Efficacy and Safety Study of Avastin to Treat Neovascularisation of the Cornea Unknown status NCT01501760 Phase 3
9 Prospective Study to Determine the Effect of Subconjunctival Bevacizumab (AVASTIN) in Corneal Neovascularization Completed NCT00555594 Phase 2, Phase 3
10 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Enrolling by invitation NCT02731638 Phase 3
11 Bevacizumab for the Treatment of Corneal Neovascularization Unknown status NCT00992849 Phase 2
12 Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose Unknown status NCT02157987 Phase 1, Phase 2
13 Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency Unknown status NCT00845117 Phase 1, Phase 2
14 Treatment of Corneal Neovascularization With Topical Pazopanib Completed NCT01257750 Phase 1, Phase 2
15 Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Completed NCT01072357 Phase 1, Phase 2
16 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
17 Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Cells of Sclerocorneal Limbus Amplified ex Vivo Completed NCT01470573 Phase 2
18 Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients Completed NCT00736307 Phase 1, Phase 2
19 Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study Recruiting NCT01843101 Phase 2
20 A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Recruiting NCT01996826 Phase 1, Phase 2
21 Limbal Epithelial Stem Cell Transplantation: a Phase II Multicenter Trial Recruiting NCT02318485 Phase 2
22 Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency Recruiting NCT01756365 Phase 1, Phase 2
23 Brimonidine Eye Drops for Treatment of Ocular Graft-vs-Host Disease (oGVHD) Recruiting NCT02975557 Phase 1, Phase 2
24 Cultivated Autologous Oral Mucosal Epithelial Transplantation for the Treatment of Ocular Surface Diseases Active, not recruiting NCT02739113 Phase 1, Phase 2
25 Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease Enrolling by invitation NCT03015779 Phase 1, Phase 2
26 Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization Not yet recruiting NCT02797704 Phase 1, Phase 2
27 Safety and Effectiveness of the RHCIII-MPC Biosynthetic Cornea in Patients Requiring Anterior Lamellar Keratoplasty Not yet recruiting NCT02424006 Phase 1, Phase 2
28 Transplantation of Cultivated Limbal Epithelium on Amniotic Membrane for Limbal Stem Cell Deficiency Suspended NCT00348114 Phase 2
29 Topical IL-1-Ra for Treatment of Corneal Neovascularization Terminated NCT00915590 Phase 1, Phase 2
30 Topical Avastin for Treatment of Corneal Neovascularization Completed NCT00559936 Phase 1
31 Effectiveness and Safety of Topical Ranibizumab for Treatment of Corneal Neovascularization (NV) Completed NCT00681889 Phase 1
32 Ranibizumab for the Inhibition of Neovascularization in the Cornea Following Corneal Transplant Surgery Completed NCT00769145 Phase 1
33 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
34 Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1
35 Ranibizumab for the Inhibition of Neovascularization in Pterygia Completed NCT00768963 Phase 1
36 The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED) Completed NCT02649621 Phase 1
37 Bevacizumab Injection for Recurrent Pterygium Completed NCT02007174 Phase 1
38 Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea Terminated NCT01868360 Phase 1
39 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1
40 Evaluation of Biosynthetic Constructs to Replace Donor Corneas Withdrawn NCT02374723 Phase 1
41 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
42 Exploratory Clinical Trials of ACM-1 in the Treatment of Ophthalmological Neovascular Diseases Unknown status NCT02448732 Early Phase 1
43 Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization Completed NCT00512876
44 Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization Completed NCT00004430
45 Photodynamic Therapy With Verteporfin for Corneal Neovascularization Completed NCT00471406
46 Safety and Effectiveness of Subconjunctival Injection of Bevacizumab in the Treatment of Corneal Neovasculization Completed NCT00681603
47 Neovascularization Patterns in Corneal Graft Rejection Completed NCT01695655
48 Comparison of Subconjuctival Versus Topical Bevacizumab as Adjunct Therapy to Trabeculectomy Completed NCT01425112
49 Vistakon Investigational Lens Worn as a Single Use Daily Wear Completed NCT01031004
50 Assessment of Daily Disposable Silicone Hydrogel Lens Wear Completed NCT01093625

Search NIH Clinical Center for Corneal Neovascularization

Cochrane evidence based reviews: corneal neovascularization

Genetic Tests for Corneal Neovascularization

Genetic tests related to Corneal Neovascularization:

id Genetic test Affiliating Genes
1 Corneal Neovascularization 29

Anatomical Context for Corneal Neovascularization

MalaCards organs/tissues related to Corneal Neovascularization:

39
Eye, Endothelial, Neutrophil, Brain

Publications for Corneal Neovascularization

Articles related to Corneal Neovascularization:

(show top 50) (show all 412)
id Title Authors Year
1
Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis. ( 28055102 )
2017
2
Inhibiting the effect of (90)Sr-(90)Y ophthalmic applicators on rat corneal neovascularization induced by sutures. ( 27672586 )
2016
3
Efficacy of Subconjunctival Aflibercept Versus Bevacizumab for Prevention of Corneal Neovascularization in a Rat Model. ( 27124775 )
2016
4
Quantitative proteomic analysis of mice corneal tissues reveals angiogenesis-related proteins involved in corneal neovascularization. ( 27049463 )
2016
5
Comparison of Topical Low-Molecular-Weight Heparin-Taurocholate and Bevacizumab for Treatment and Prevention of Corneal Neovascularization. ( 27941385 )
2016
6
Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization. ( 27018842 )
2016
7
Host immune cellular reactions in corneal neovascularization. ( 27162740 )
2016
8
Assessment of therapeutic options for reducing alkali burn-induced corneal neovascularization and inflammation. ( 26651127 )
2016
9
Subconjunctival injection of antagomir-21 alleviates corneal neovascularization in a mouse model of alkali-burned cornea. ( 28052006 )
2016
10
Celastrol nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats. ( 27920521 )
2016
11
Attenuation of corneal neovascularization by topical low-molecular-weight heparin-taurocholate 7 without bleeding complication. ( 27672587 )
2016
12
Mapping Murine Corneal Neovascularization and Weight Loss Virulence Determinants in the Herpes Simplex Virus 1 Genome and the Detection of an Epistatic Interaction between the UL and IRS/US Regions. ( 27384650 )
2016
13
Transfer of mesenchymal stem cells and cyclosporine A on alkali-injured rabbit cornea using nanofiber scaffolds strongly reduces corneal neovascularization and scar formation. ( 26797822 )
2016
14
Inhibitory effects of (90)Sr/(90)Y I^-irradiation on alkali burn-induced corneal neovascularization in rats. ( 26893623 )
2016
15
Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization. ( 27149536 )
2016
16
Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization. ( 27625050 )
2016
17
Effects of Combined Photodynamic Therapy and Topical Bevacizumab Treatment on Corneal Neovascularization in Rabbits. ( 27684458 )
2016
18
Efficacy of topical aflibercept versus topical bevacizumab for the prevention of corneal neovascularization in a rat model. ( 27020759 )
2016
19
Inhibition of VEGF mediated corneal neovascularization by anti-angiogenic peptide nanofibers. ( 27616429 )
2016
20
Intrastromal Injection of Bevacizumab in the Management of Corneal Neovascularization: About 25 Eyes. ( 27610242 )
2016
21
Mesenchymal stem cells in corneal neovascularization: Comparison of different application routes. ( 27514011 )
2016
22
NADPH oxidase 2 plays a role in experimental corneal neovascularization. ( 26814205 )
2016
23
Reducible Polyethylenimine Nanoparticles for Efficient siRNA Delivery in Corneal Neovascularization Therapy. ( 27503770 )
2016
24
A Novel Peptide Derived from Tissue-Type Plasminogen Activator Potently Inhibits Angiogenesis and Corneal Neovascularization. ( 27618679 )
2016
25
Topical Use of Angiopoietin-like Protein 2 RNAi-loaded Lipid Nanoparticles Suppresses Corneal Neovascularization. ( 27111418 )
2016
26
Synthetic stigmasterol derivatives inhibit capillary tube formation, herpetic corneal neovascularization and tumor induced angiogenesis. ( 27623061 )
2016
27
Therapeutic effects of a novel PIGF-1 derived peptide, ZY-1, on corneal neovascularization in vitro and in vivo. ( 27355331 )
2016
28
Interleukin (IL)-17A Promotes Angiogenesis in an Experimental Corneal Neovascularization Model. ( 27419340 )
2016
29
Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice. ( 26120273 )
2015
30
Identification of Corneal Neovascularization-Related Long Noncoding RNAs Through Microarray Analysis. ( 25747163 )
2015
31
Inhibitory effect of polysulfated heparin endostatin on alkali burn induced corneal neovascularization in rabbits. ( 25938033 )
2015
32
Inhibitory Effect of Topical Aflibercept on Corneal Neovascularization in Rabbits. ( 26114826 )
2015
33
Topically administered gold nanoparticles inhibit experimental corneal neovascularization in mice. ( 25625363 )
2015
34
Intrastromal bevacizumab injection for corneal neovascularization in herpetic stromal keratitis. ( 26342658 )
2015
35
Angiographic-guided treatment of corneal neovascularization. ( 25763557 )
2015
36
Effects of lapatinib and trastuzumab on vascular endothelial growth factor in experimental corneal neovascularization. ( 25640924 )
2015
37
Anti-apoptosis effects of vascular endothelial cadherin in experimental corneal neovascularization. ( 26682152 )
2015
38
Corneal Indocyanine Green Angiography to Guide Medical and Surgical Management of Corneal Neovascularization. ( 26555579 )
2015
39
Comparative study of tacrolimus and bevacizumab on corneal neovascularization in rabbits. ( 25651492 )
2015
40
High-mobility group box-1-Toll-Like receptor 4 axis mediates the recruitment of endothelial progenitor cells in alkali-induced corneal neovascularization. ( 26202806 )
2015
41
Imidazole-based alkaloid derivative LCB54-0009 suppresses ocular angiogenesis and lymphangiogenesis in models of experimental retinopathy and corneal neovascularization. ( 25917462 )
2015
42
Curcumin nanoparticles inhibit corneal neovascularization. ( 25877858 )
2015
43
Angiogenesis: A special reference to corneal neovascularization. ( 26226726 )
2015
44
AA092, an annonaceous acetogenin mimetic, attenuates angiogenesis in a mouse model of inflammation-induced corneal neovascularization. ( 26303770 )
2015
45
Corneal neovascularization and biological therapy. ( 26664467 )
2015
46
Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats. ( 25853509 )
2015
47
Corneal Fine Needle Diathermy With Adjuvant Bevacizumab to Treat Corneal Neovascularization in Children. ( 25811720 )
2015
48
Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis. ( 26491546 )
2015
49
Prophylactic effect of topical silica nanoparticles as a novel antineovascularization agent for inhibiting corneal neovascularization following chemical burn. ( 26261826 )
2015
50
Inhibition of Pathologic Corneal Neovascularization by Topical Application of a Novel Peptide In Vivo. ( 26266428 )
2015

Variations for Corneal Neovascularization

Expression for Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for Corneal Neovascularization

Pathways related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 CD36 CXCL12 KDR PLG THBS1 VEGFA
2
Show member pathways
13.14 CD36 HRG PLG TEK THBS1 VEGFA
3
Show member pathways
13.08 CXCL12 FGF2 FLT1 KDR TEK VEGFA
4
Show member pathways
12.59 FGF2 KDR PLG THBS1
5
Show member pathways
12.54 CXCL12 FGF2 FLT1 KDR
6
Show member pathways
12.52 FGF2 FLT1 KDR TEK THBS1 VEGFA
7 12.38 FGF2 FLT1 KDR TEK THBS1 VEGFA
8
Show member pathways
12.23 FGF2 FLT1 KDR VEGFA
9 12.14 FGF2 KDR THBS1 VEGFA
10
Show member pathways
12.08 FGF2 FLT1 KDR VEGFA
11
Show member pathways
12.03 FLT1 KDR TEK
12
Show member pathways
11.98 CD36 KDR THBS1
13 11.95 FGF2 FLT1 KDR TEK
14 11.91 FGF2 KDR VEGFA
15
Show member pathways
11.84 FLT1 KDR VEGFA
16 11.83 CD36 FGF2 VEGFA
17 11.75 FLT1 TEK VEGFA
18
Show member pathways
11.71 FLT1 KDR VEGFA
19 11.71 CXCL12 FLT1 TEK VEGFA
20 11.55 FLT1 KDR VEGFA
21 11.35 FGF2 KDR VEGFA
22 11.31 FGF2 KDR PLG VEGFA
23 11.29 FGF2 FLT1 KDR TEK THBS1
24 11.18 FLT1 KDR VEGFA
25 11.05 CXCL12 FGF2 PLG THBS1
26 10.87 FGF2 FLT1 SLIT2 VEGFA
27
Show member pathways
10.81 FLT1 KDR VEGFA
28 10.71 HRG PLG
29 10.4 FGF2 FLT1 KDR TEK VEGFA

GO Terms for Corneal Neovascularization

Cellular components related to Corneal Neovascularization according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 CD36 HRG PLG TEK THBS1 VEGFA
2 extracellular space GO:0005615 9.61 CD36 CXCL12 FGF2 FLT1 PLG SERPINF1
3 platelet alpha granule lumen GO:0031093 9.46 HRG PLG THBS1 VEGFA
4 extracellular region GO:0005576 9.36 CXCL12 FGF2 FLT1 HRG KDR PLG

Biological processes related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 49)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.95 CXCL12 FGF2 FLT1 KDR THBS1 VEGFA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 CD36 FGF2 KDR TEK
3 response to hypoxia GO:0001666 9.91 CXCL12 TEK THBS1 VEGFA
4 peptidyl-tyrosine phosphorylation GO:0018108 9.9 FGF2 FLT1 KDR TEK
5 protein autophosphorylation GO:0046777 9.88 FLT1 KDR TEK
6 chemotaxis GO:0006935 9.88 CXCL12 FGF2 FLT1 HRG SLIT2
7 positive regulation of protein phosphorylation GO:0001934 9.87 KDR TEK VEGFA
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.86 FLT1 KDR TEK
9 positive regulation of MAPK cascade GO:0043410 9.84 CD36 FLT1 KDR
10 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.83 FLT1 KDR VEGFA
11 platelet degranulation GO:0002576 9.83 CD36 HRG PLG THBS1 VEGFA
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.82 FLT1 KDR TEK
13 positive regulation of MAP kinase activity GO:0043406 9.81 FGF2 FLT1 VEGFA
14 negative regulation of angiogenesis GO:0016525 9.81 HRG SERPINF1 TEK THBS1
15 positive regulation of cell migration GO:0030335 9.8 CXCL12 FLT1 KDR THBS1 VEGFA XBP1
16 positive chemotaxis GO:0050918 9.76 CXCL12 FGF2 VEGFA
17 positive regulation of endothelial cell migration GO:0010595 9.76 KDR TEK THBS1 VEGFA
18 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.74 FGF2 FLT1 TEK
19 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.73 FLT1 KDR VEGFA
20 positive regulation of blood vessel endothelial cell migration GO:0043536 9.72 FGF2 THBS1 VEGFA
21 negative regulation of endothelial cell migration GO:0010596 9.71 SERPINF1 SLIT2 THBS1
22 branching morphogenesis of an epithelial tube GO:0048754 9.7 SLIT2 VEGFA
23 negative regulation of endothelial cell apoptotic process GO:2000352 9.7 KDR TEK
24 sprouting angiogenesis GO:0002040 9.7 TEK THBS1
25 negative regulation of blood vessel endothelial cell migration GO:0043537 9.7 FGF2 HRG THBS1
26 fibrinolysis GO:0042730 9.69 HRG PLG
27 endothelial cell proliferation GO:0001935 9.69 TEK XBP1
28 embryonic morphogenesis GO:0048598 9.68 FGF2 FLT1
29 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 FLT1 VEGFA
30 positive regulation of blood coagulation GO:0030194 9.68 CD36 THBS1
31 induction of positive chemotaxis GO:0050930 9.67 CXCL12 VEGFA
32 positive regulation of positive chemotaxis GO:0050927 9.67 KDR VEGFA
33 negative regulation of fibrinolysis GO:0051918 9.67 HRG PLG THBS1
34 positive regulation of focal adhesion assembly GO:0051894 9.67 HRG KDR TEK VEGFA
35 positive regulation of phospholipase C activity GO:0010863 9.66 FGF2 FLT1
36 positive regulation of axon extension involved in axon guidance GO:0048842 9.65 CXCL12 VEGFA
37 vascular endothelial growth factor signaling pathway GO:0038084 9.65 FLT1 KDR
38 positive regulation of endothelial cell proliferation GO:0001938 9.65 CXCL12 FGF2 KDR TEK VEGFA
39 regulation of cGMP metabolic process GO:0030823 9.63 THBS1 VEGFA
40 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.63 KDR VEGFA
41 negative regulation of lamellipodium assembly GO:0010593 9.61 HRG SLIT2
42 negative regulation of endothelial cell chemotaxis GO:2001027 9.59 HRG THBS1
43 angiogenesis GO:0001525 9.5 FGF2 FLT1 HRG KDR TEK VEGFA
44 cell migration involved in sprouting angiogenesis GO:0002042 9.46 FGF2 KDR SLIT2 VEGFA
45 positive regulation of angiogenesis GO:0045766 9.17 FGF2 FLT1 KDR TEK THBS1 VEGFA
46 multicellular organism development GO:0007275 10.12 FGF2 FLT1 KDR SERPINF1 SLIT2 VEGFA
47 cell differentiation GO:0030154 10.1 FGF2 FLT1 KDR SLIT2 VEGFA XBP1
48 negative regulation of apoptotic process GO:0043066 10.04 KDR TEK THBS1 VEGFA XBP1
49 immune response GO:0006955 10.01 CD36 CXCL12 THBS1 XBP1

Molecular functions related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.65 CXCL12 FGF2 VEGFA
2 protein tyrosine kinase activity GO:0004713 9.56 FGF2 FLT1 KDR TEK
3 extracellular matrix binding GO:0050840 9.52 THBS1 VEGFA
4 fibronectin binding GO:0001968 9.51 THBS1 VEGFA
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 FLT1 KDR TEK
6 transforming growth factor beta binding GO:0050431 9.46 CD36 THBS1
7 low-density lipoprotein particle binding GO:0030169 9.43 CD36 THBS1
8 proteoglycan binding GO:0043394 9.4 SLIT2 THBS1
9 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 FLT1 KDR
10 growth factor binding GO:0019838 9.33 FLT1 KDR TEK
11 chemoattractant activity GO:0042056 9.13 CXCL12 FGF2 VEGFA
12 heparin binding GO:0008201 9.02 FGF2 HRG SLIT2 THBS1 VEGFA
13 protein binding GO:0005515 10.27 CD36 FGF2 FLT1 HRG KDR PLG

Sources for Corneal Neovascularization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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