MCID: CRN027
MIFTS: 55

Corneal Neovascularization malady

Eye diseases category

Summaries for Corneal Neovascularization

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63Wikipedia, 32MalaCards
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Wikipedia:63 Corneal neovascularization is the excessive ingrowth of blood vessels from the limbal vascular plexus... more...

MalaCards: Corneal Neovascularization, also known as corneal neovascularization, unspecified, is related to keratitis and herpes simplex. An important gene associated with Corneal Neovascularization is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are Cell adhesion Plasmin signaling and Integrins in angiogenesis. The compounds cycloheximide and suramin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and brain, and related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Corneal Neovascularization

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal neovascularization 8 44 60
corneal neovascularization, unspecified 8
unspecified corneal neovascularization 8
corneal neovascularization nos 8


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Disease Ontology8 DOID:11382
MeSH34 D016510
ICD9CM27 370.6, 370.60
ICD1025 H16.4

Related Diseases for Corneal Neovascularization

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17GeneCards, 18GeneDecks
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Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1keratitis30.6MMP2, FGF2, VEGFA
2herpes simplex30.0TIMP2, THBS1, CXCL10
3burns10.6
4limbal stem cell deficiency10.2
5corneal deposit10.2
6keratopathy10.2
7corneal disease10.0
8axenfeld-rieger syndrome10.0
9corneal granular dystrophy10.0
10corneal dystrophy10.0
11pterygium10.0
12retinitis10.0
13hypertension10.0PLG
14liver cirrhosis10.0PLG
15hemangioendothelioma10.0PLG
16synovitis10.0TIMP2
17pituitary adenoma10.0FGF2
18myopia 610.0SERPINF1
19hyperglycemia10.0SERPINF1
20moyamoya disease10.0FGF2
21biliary atresia10.0CXCL10
22pituitary tumors10.0FGF2
23retinal vein occlusion10.0VEGFA
24gastric ulcer10.0FGF2
25pneumonia10.0CXCL10
26disseminated intravascular coagulation10.0PF4
27antiphospholipid syndrome10.0PF4
28meningioma10.0FLT1
29hemorrhagic disease10.0PLG
30meningitis10.0CXCL10
31retinal ischemia10.0VEGFA
32rhabdomyosarcoma10.0FLT1
33cholangiocarcinoma10.0THBS1
34hepatitis b10.0CXCL10
35goiter10.0TEK
36pre-eclampsia10.0FLT1
37stroke, ischemic10.0PF4
38pulmonary emphysema10.0TIMP2
39retinal detachment10.0VEGFA, SERPINF1
40essential hypertension10.0PF4
41retinopathy of prematurity10.0FLT1, VEGFA
42laryngeal benign neoplasm10.0MMP2
43fibromatosis10.0TIMP2
44acute leukemia10.0CXCL12
45adenoma10.0THBS1, FLT1
46diabetic macular edema10.0VEGFA, SERPINF1
47age related macular degeneration10.0FLT1, VEGFA
48retinoblastoma10.0FLT1, SERPINF1
49protein c deficiency10.0PLG, HRG
50gingival overgrowth10.0CD36

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to corneal neovascularization

Clinical Features for Corneal Neovascularization

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Drugs & Therapeutics for Corneal Neovascularization

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Corneal Neovascularization

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Anatomical Context for Corneal Neovascularization

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32MalaCards
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MalaCards organs/tissues related to Corneal Neovascularization:

32
Endothelial, Eye, Brain

Animal Models for Corneal Neovascularization or affiliated genes

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36MGI
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Publications for Corneal Neovascularization

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50PubMed
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Articles related to Corneal Neovascularization:

(show top 50)    (show all 340)
idTitleAuthorsYear
1
The inhibitory effect of thalidomide analogue on corneal neovascularization in rabbits. (23739149)
2013
2
Corneal neovascularization: An enigma. (24379562)
2013
3
Managements for corneal neovascularization. (24055908)
2013
4
Safety and efficacy of the multitargeted receptor kinase inhibitor pazopanib in the treatment of corneal neovascularization. (23233252)
2013
5
Corneal neovascularization: an anti-VEGF therapy review. (22898649)
2012
6
Contact lens use with intraestromal hemorrhage secondary to corneal neovascularization. (23386098)
2012
7
Effects of subconjunctival bevacizumab on corneal neovascularization: results of a prospective study. (22357391)
2012
8
Studies on Axenfeld-Rieger syndrome patients and mice reveal Foxc1's role in corneal neovascularization. (22308435)
2012
9
FOXC1-associated phenotypes in humans may not always exhibit corneal neovascularization. (22582167)
2012
10
Treatments for corneal neovascularization: a review. (21389854)
2011
11
Potential involvement of nitric oxide synthase but not inducible nitric oxide synthase in the development of experimental corneal neovascularization. (22553677)
2011
12
Subconjunctival injection of bevacizumab in the treatment of corneal neovascularization associated with lipid deposition. (20847676)
2011
13
KH906, a recombinant human VEGF receptor fusion protein, is a new effective topical treatment for corneal neovascularization. (21528000)
2011
14
Potential anti-angiogenic role of Slit2 in corneal neovascularization. (20298689)
2010
15
The effect of bevacizumab on corneal neovascularization in rabbits. (20714387)
2010
16
Inhibition of corneal neovascularization by topical bevacizumab (Anti-VEGF) and Sunitinib (Anti-VEGF and Anti-PDGF) in an animal model. (20591397)
2010
17
The effect of subconjuctival combined treatment of bevacizumab and triamcinolone acetonide on corneal neovascularization in rabbits. (20098156)
2010
18
Effect of bevacizumab on corneal neovascularization in experimental rabbit model. (19788671)
2009
19
Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist. (19458323)
2009
20
Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. (19421039)
2009
21
Therapeutic effect of subconjunctival injection of bevacizumab in the treatment of corneal neovascularization. (19021596)
2009
22
Limbal stem cell deficiency and corneal neovascularization. (19437349)
2009
23
Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study. (19365012)
2009
24
Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. (18322241)
2008
25
Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis. (17690185)
2007
26
Subconjunctival bevacizumab for corneal neovascularization. (17458556)
2007
27
Endogenous TNFalpha suppression of neovascularization in corneal stroma in mice. (17591872)
2007
28
Topical bevacizumab therapy for corneal neovascularization. (17562998)
2007
29
Experimental inhibition of corneal neovascularization by photodynamic therapy with verteporfin. (16531278)
2006
30
The expression of nuclear factor kappa B in inflammation-induced rat corneal neovascularization. (17162607)
2006
31
Activation of CD36 inhibits and induces regression of inflammatory corneal neovascularization. (17003426)
2006
32
Prevention of corneal neovascularization: evaluation of various commercially available compounds in an experimental rat model. (17068457)
2006
33
Lipid-mediated delivery of brain-specific angiogenesis inhibitor 1 gene reduces corneal neovascularization in an in vivo rabbit model. (15703766)
2005
34
Gene expression profile in corneal neovascularization identified by immunology related macroarray. (15547492)
2004
35
Subjective symptom of eye dryness and lifestyle factors with corneal neovascularization in contact lens wearers. (15260357)
2004
36
Expression of tissue inhibitor of metalloproteinase-4 in normal human corneal cells and experimental corneal neovascularization. (12815195)
2003
37
Inhibition of corneal neovascularization by genetic ablation of CCR2. (12827053)
2003
38
Photodynamic therapy of corneal neovascularization with verteporfin. (12827058)
2003
39
Lipid hydroperoxide induced corneal neovascularization in hyperglycemic rabbits. (12518243)
2002
40
Histological evaluation of phthalocyanine mediated photodynamic occlusion of corneal neovascularization enhanced by hyperbaric oxygenation. (8653523)
1996
41
Corneal neovascularization in rats as a model for photothrombotic therapy using bacteriochlorin a and an argon laser. (7557509)
1995
42
Comparison of yellow dye, continuous wave Nd:YAG, and argon green laser on experimentally induced corneal neovascularization. (7641049)
1995
43
The effects on inhibition of corneal neovascularization after human amniotic membrane transplantation in severely damaged rabbit corneas. (7674551)
1995
44
Interleukin-2 induces corneal neovascularization in A/J mice. (1706652)
1990
45
Corneal neovascularization induced by stimulated lymphocytes in inbred mice. (2442116)
1987
46
Corneal effect of isotretinoin: possible exacerbation of corneal neovascularization in a patient with the keratitis, ichthyosis, deafness ("KID") syndrome. (2419373)
1986
47
Indomethacin v. dexamethasone in the suppression of corneal neovascularization. (6197150)
1983
48
Corneal neovascularization from extended wear lenses. (6188773)
1983
49
Autoradiographic study of corneal neovascularization induced by chemical cautery. (6170832)
1981
50
Use of flurbiprofen to inhibit corneal neovascularization. (6155898)
1980

Genetic Variations for Corneal Neovascularization

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Expression for genes affiliated with Corneal Neovascularization

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Neovascularization

Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for genes affiliated with Corneal Neovascularization

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 53Reactome, 51QIAGEN, 52R&D Systems, 49PharmGKB, 55SinoBiological
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Pathways related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PLG
210.3VEGFA
310.2FLT1
410.2KDR
510.2TEK
610.1PLG, HRG
79.8FLT1, VEGFA, KDR
89.8FLT1, VEGFA, KDR
9
Hide members
9.8KDR, VEGFA, FLT1
10
Hide members
9.8KDR, VEGFA, FLT1
11
Hide members
9.8KDR, VEGFA, FLT1
12
Hide members
9.8KDR, VEGFA, FLT1
13
Cell adhesion ECM remodeling
Hide members
9.8PLG, MMP2, TIMP2
149.7FLT1, KDR, TEK
15
Hide members
9.6HRG, PLG, THBS1, TEK
16
Hide members
9.6TIMP4, FKBP1A
179.6PF4, CXCL10, CXCL12
18
Hide members
9.6FLT1, VEGFA, FGF2, KDR
199.6THBS1, PLG, CXCL12, FGF2
20
Hide members
9.6TIMP2, TIMP4, CXCL12
21
Hide members
9.5MMP2, TIMP4, TIMP2
22
Hide members
9.5FLT1, VEGFA, KDR, THBS1
23
Development PDGF signaling via STATs and NF-kB
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9.5FGF2, MMP2, PLG, TEK
24
Transcription P53 signaling pathway
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9.4FLT1, VEGFA, MMP2, KDR
259.4VEGFA, FKBP1A, FGF2, THBS1
26
Hide members
9.3TIMP2, FGF2, MMP2, PLG, THBS1
27
Hide members
9.3FLT1, CXCL10, CXCL12, TEK, SERPINF1
289.3VEGFA, FGF2, MMP2, KDR, THBS1
29
Hide members
9.2TIMP2, FLT1, CXCL12, KDR, TEK
30
Hide members
9.1TIMP4, FLT1, FGF2, KDR, TEK
319.1TEK, KDR, FGF2, VEGFA, FLT1, TIMP2
329.1FLT1, VEGFA, FGF2, KDR, THBS1, TEK
339.0TIMP2, FLT1, FGF2, MMP2, KDR, TEK
34
Hide members
8.9VEGFA, CD36, PF4, HRG, PLG, THBS1
35
Hide members
8.9TIMP2, TIMP4, FLT1, FGF2, CXCL12, KDR
36
Hide members
8.6TEK, KDR, CXCL12, CXCL10, PF4, FLT1
37
Hide members
8.6TIMP2, TIMP4, FLT1, FGF2, CXCL12, KDR
38
Hide members
8.6TIMP2, TIMP4, FLT1, FGF2, CXCL12, KDR
39
Hide members
8.3TIMP2, TIMP4, FLT1, FGF2, CXCL12, MMP2
40
Hide members
8.3CD36, PF4, CXCL10, CXCL12, MMP2, PLG
41
Hide members
8.2TIMP2, TIMP4, FLT1, FGF2, CXCL12, MMP2
42
Hide members
8.0TIMP2, TIMP4, FLT1, PF4, FGF2, CXCL10
43
Hide members
8.0CXCL12, CXCL10, FGF2, PF4, FLT1, TIMP4
44
Hide members
7.8FLT1, VEGFA, FKBP1A, PF4, FGF2, CXCL10

Compounds for genes affiliated with Corneal Neovascularization

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB, 49PharmGKB
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Compounds related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.3CXCL10, CXCL12
2suramin44 28 1112.2KDR, PLG, CXCL10
3alginate4410.2CD36, PLG
4fumagillin44 59 1112.2PLG, FGF2, VEGFA
5su66684410.1FGF2, VEGFA, KDR
6carboxyamidotriazole4410.1VEGFA, MMP2, FGF2
7ptk7874410.1FLT1, VEGFA, KDR
8chondroitin sulfate44 2411.1HRG, THBS1, CD36
9pge24410.0MMP2, VEGFA, PF4
10zd6474449.9FLT1, VEGFA, KDR
11hydrocortisone44 2 59 1112.9KDR, MMP2, FGF2, FLT1
12axitinib44 59 1111.8FLT1, VEGFA, KDR
13paclitaxel44 49 1111.8THBS1, PLG, VEGFA, TIMP2, KDR
14tamoxifen44 49 28 1112.7THBS1, CXCL12, KDR, PLG
15gefitinib44 49 1111.7FGF2, MMP2, KDR, VEGFA, PLG
16dexamethasone44 49 28 1112.7VEGFA, FGF2, CXCL12, KDR, SERPINF1
17fucoidan449.6CXCL12, CD36, THBS1, KDR, FGF2
181,10-phenanthroline44 210.5MMP2, TIMP2, TIMP4, CXCL12
19infliximab44 49 1111.5CXCL10, TEK, VEGFA, FGF2
20thalidomide44 49 59 1112.5THBS1, CD36, VEGFA, PLG, FGF2, KDR
21dermatan sulfate449.4PF4, FGF2, HRG
22prostacyclin449.3THBS1, KDR, FGF2, PF4, VEGFA, FLT1
23cytochalasin d44 5910.3CD36, CXCL12, TIMP2, FGF2, MMP2, THBS1
24ribonucleic acid449.2TEK, TIMP2, FLT1, MMP2, CXCL12, THBS1
25fibrinogen449.2HRG, PF4, CXCL12, PLG, THBS1, TIMP2
26herbimycin a44 5910.2MMP2, CXCL12, FGF2, TIMP2, CD36
27heparan sulfate44 2410.2FGF2, THBS1, CXCL10, CXCL12, HRG, KDR
28oxygen44 2410.1TIMP2, FLT1, FKBP1A, PF4, TEK, SERPINF1
29hyaluronic acid44 2410.1THBS1, MMP2, CXCL12, VEGFA, FGF2, CD36
30matrigel449.1FLT1, TEK, THBS1, KDR, HRG, CXCL12
31tgf beta1448.9THBS1, CD36, MMP2, FLT1, PF4, FGF2
32nitric oxide44 11 2410.9SERPINF1, TEK, TIMP2, FLT1, CXCL10, THBS1
33glycosaminoglycan448.9CD36, PF4, SERPINF1, CXCL12, FGF2, CXCL10
34rapamycin448.9FLT1, FKBP1A, CXCL12, KDR, THBS1, VEGFA
35h2o2448.9FLT1, TIMP2, SERPINF1, THBS1, MMP2, FGF2
36sb 20358044 599.8THBS1, MMP2, CXCL12, FGF2, CD36, TIMP2
37wortmannin448.8PF4, CXCL10, KDR, CXCL12, MMP2, THBS1
38heparin44 28 11 2411.7SERPINF1, TIMP2, FLT1, VEGFA, CD36, PF4
395fluorouracil448.7PF4, KDR, MMP2, CXCL12, CD36, VEGFA
40paraffin448.6CD36, VEGFA, TEK, THBS1, KDR, MMP2
41thymidine44 249.5CXCL12, KDR, THBS1, TEK, TIMP2, FLT1
42serine448.4TIMP2, FGF2, FLT1, FKBP1A, PLG, HRG
43genistein44 28 59 2 11 2413.4FLT1, THBS1, KDR, MMP2, CXCL10, FGF2
44phosphatidylinositol448.4FLT1, FGF2, FKBP1A, CXCL10, KDR, CXCL12
45ly294002448.4KDR, THBS1, FGF2, MMP2, CXCL12, CD36
46cysteine448.3TIMP2, CD36, PF4, THBS1, KDR, HRG
47lipid448.1PF4, FLT1, FKBP1A, CXCL12, CXCL10, THBS1
48tyrosine448.0FLT1, TEK, SERPINF1, KDR, PLG, CXCL12
49calcium44 49 11 2410.5CXCL10, PF4, FLT1, CD36, PLG, TIMP2
50vegf447.1PF4, CD36, VEGFA, FLT1, TIMP2, FGF2

GO Terms for genes affiliated with Corneal Neovascularization

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16Gene Ontology
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Cellular components related to Corneal Neovascularization according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2PF4, HRG, PLG, THBS1, VEGFA
2cell surfaceGO:0099869.0TIMP2, VEGFA, CD36, PLG, THBS1, TEK
3external side of plasma membraneGO:0098978.2CD36, CXCL10, THBS1, KDR, ROBO4, CXCL12
4extracellular spaceGO:0056157.4PF4, VEGFA, FLT1, TIMP4, TIMP2, FGF2
5extracellular regionGO:0055767.0SERPINF1, TIMP2, TIMP4, VEGFA, PF4, FGF2

Biological processes related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1embryonic morphogenesisGO:04859810.3FGF2, FLT1
2negative regulation of fibrinolysisGO:05191810.3HRG, THBS1, PLG
3positive regulation of phospholipase C activityGO:01086310.3FLT1, FGF2
4negative regulation of blood vessel endothelial cell migrationGO:04353710.3THBS1, FGF2, HRG
5positive regulation of blood vessel endothelial cell migrationGO:04353610.2FGF2, THBS1, VEGFA
6positive regulation of intracellular protein kinase cascadeGO:01074010.2TEK, VEGFA
7cell migration involved in sprouting angiogenesisGO:00204210.2FGF2, KDR, VEGFA
8positive regulation of positive chemotaxisGO:05092710.2VEGFA, KDR
9surfactant homeostasisGO:04312910.2VEGFA, KDR
10cellular response to vascular endothelial growth factor stimulusGO:03592410.1VEGFA, FLT1, KDR
11positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.1FGF2, TEK, FLT1
12vascular endothelial growth factor receptor signaling pathwayGO:04801010.1KDR, FLT1, VEGFA
13sprouting angiogenesisGO:00204010.1TEK, THBS1, FLT1
14patterning of blood vesselsGO:00156910.0CXCL12, FLT1, VEGFA
15positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.0FLT1, TEK, KDR
16positive regulation of protein phosphorylationGO:00193410.0VEGFA, KDR
17peptidyl-tyrosine phosphorylationGO:01810810.0FLT1, KDR, TEK
18positive regulation of blood coagulationGO:03019410.0THBS1, CD36
19positive regulation of focal adhesion assemblyGO:05189410.0TEK, HRG, KDR, VEGFA
20negative regulation of endothelial cell apoptotic processGO:200035210.0TEK, KDR
21transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.0TEK, FLT1, KDR
22positive regulation of endothelial cell proliferationGO:0019389.9TEK, VEGFA, FGF2, KDR
23chemotaxisGO:0069359.9HRG, CXCL12, CXCL10, FGF2
24positive regulation of endothelial cell migrationGO:0105959.9VEGFA, TEK, THBS1, KDR
25extracellular matrix disassemblyGO:0226179.9TIMP2, MMP2, PLG
26positive regulation of cell migrationGO:0303359.9KDR, FLT1, THBS1, VEGFA
27positive regulation of MAPK cascadeGO:0434109.8KDR, FLT1, TIMP2, CD36
28extracellular matrix organizationGO:0301989.7PLG, MMP2, FGF2, TIMP2, THBS1
29positive regulation of cell proliferationGO:0082849.6FGF2, KDR, CXCL10, FLT1, VEGFA
30positive regulation of angiogenesisGO:0457669.5TEK, FLT1, VEGFA, FGF2, KDR, THBS1
31negative regulation of angiogenesisGO:0165259.5PF4, CXCL10, HRG, THBS1, SERPINF1, TEK
32positive regulation of ERK1 and ERK2 cascadeGO:0703749.5TEK, KDR, FGF2
33immune responseGO:0069559.4CXCL12, PF4, THBS1, XBP1, CXCL10
34platelet degranulationGO:0025769.4PLG, VEGFA, CD36, PF4, HRG, THBS1
35platelet activationGO:0301689.3PLG, VEGFA, THBS1, CD36, PF4, HRG
36response to drugGO:0424939.2TIMP2, THBS1, XBP1, TIMP4
37blood coagulationGO:0075969.1CD36, PF4, HRG, PLG, THBS1, TEK
38angiogenesisGO:0015259.0TEK, ROBO4, VEGFA, KDR, HRG, MMP2

Molecular functions related to Corneal Neovascularization according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:00502110.0KDR, FLT1
2metalloendopeptidase inhibitor activityGO:0081919.9TIMP2, TIMP4
3transmembrane receptor protein tyrosine kinase activityGO:0047149.8TEK, KDR, FLT1
4integrin bindingGO:0051789.7THBS1, KDR, TIMP2
5chemokine activityGO:0080099.7PF4, CXCL10, CXCL12
6transforming growth factor beta bindingGO:0504319.6THBS1, CD36
7heparin bindingGO:0082019.4VEGFA, PF4, FGF2, HRG, THBS1

Products for genes affiliated with Corneal Neovascularization

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  • Antibodies
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Sources for Corneal Neovascularization

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet