MCID: CRN027
MIFTS: 40

Corneal Neovascularization malady

Eye diseases category

Summaries for Corneal Neovascularization

About this section


Wikipedia:63 Corneal neovascularization is the excessive ingrowth of blood vessels from the limbal vascular plexus... more...

MalaCards based summary: Corneal Neovascularization, also known as corneal neovascularization, unspecified, is related to endotheliitis and burns. An important gene associated with Corneal Neovascularization is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Dissolution of Fibrin Clot. The compounds epsilon aminocaproic acid and kininogen have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and brain, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Corneal Neovascularization

About this section
Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 25ICD10
See all sources

Corneal Neovascularization, Aliases & Descriptions:

Name: Corneal Neovascularization 9 43 60
Corneal Neovascularization, Unspecified 9
 
Unspecified Corneal Neovascularization 9
Corneal Neovascularization Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:11382
MeSH33 D016510
ICD9CM27 370.60, 370.6
ICD1025 H16.4

Related Diseases for Corneal Neovascularization

About this section

Diseases related to Corneal Neovascularization via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1endotheliitis10.7
2burns10.7
3keratitis10.5
4diabetic macular edema10.4SERPINF1
5stromal keratitis10.3
6keratopathy10.2
7limbal stem cell deficiency10.2
8hypoxia10.2
9uveitis10.2CXCL10, SERPINF1
10retinal vascular disease10.2PLG, SERPINF1
11protein c deficiency10.1HRG, PLG
12thrombophilia10.1HRG, PLG
13thrombophilia due to thrombin defect10.1HRG, PLG
14corneal intraepithelial dyskeratosis and ectodermal dysplasia10.1
15corneal dystrophy10.1
16herpes simplex10.1
17retinitis10.1
18acanthamoeba keratitis10.1
19hypersensitivity reaction type ii disease10.1PLG, CXCL10
20microvascular complications of diabetes 310.1PLG, SERPINF1
21acute myocardial infarction10.0HRG, PLG
22kaposi sarcoma10.0FGF2, CXCL10
23retinal degeneration10.0FGF2, SERPINF1
24pulmonary fibrosis, idiopathic10.0FGF2, CXCL10
25vascular cancer10.0PLG, FGF2
26bladder cancer, somatic9.9PLG, FGF2
27pancreatic cancer9.9FGF2, PLG
28rheumatoid arthritis9.9HRG, PLG, CXCL10
29fibrosarcoma9.9PLG, FGF2
30microvascular complications of diabetes 19.9FGF2, CXCL10, SERPINF1
31adenocarcinoma9.8PLG, CXCL10, SERPINF1
32brain cancer9.8FGF2, PLG
33microvascular complications of diabetes 59.8FGF2, PLG, SERPINF1
34endometrial cancer9.8FGF2, PLG
35arthritis9.8FGF2, PLG, CXCL10
36hepatocellular carcinoma9.8SERPINF1, PLG, FGF2
37tongue squamous cell carcinoma9.7FGF2, PLG, SERPINF1
38malignant glioma9.7PLG, FGF2
39leukemia9.6SERPINF1, PLG, FGF2
40lung cancer9.6SERPINF1, CXCL10, PLG, FGF2
41atherosclerosis9.6FGF2, PLG, CXCL10, SERPINF1
42melanoma9.6SERPINF1, CXCL10, PLG, FGF2
43prostate cancer9.6FGF2, PLG, CXCL10, SERPINF1
44breast cancer9.6SERPINF1, CXCL10, PLG, FGF2

Graphical network of the top 20 diseases related to Corneal Neovascularization:



Diseases related to corneal neovascularization

Symptoms for Corneal Neovascularization

About this section

Drugs & Therapeutics for Corneal Neovascularization

About this section

Drug clinical trials:

Search ClinicalTrials for Corneal Neovascularization

Search NIH Clinical Center for Corneal Neovascularization

Genetic Tests for Corneal Neovascularization

About this section

Anatomical Context for Corneal Neovascularization

About this section

MalaCards organs/tissues related to Corneal Neovascularization:

31
Eye, Endothelial, Brain, Neutrophil

Animal Models for Corneal Neovascularization or affiliated genes

About this section

MGI Mouse Phenotypes related to Corneal Neovascularization:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6FGF2, PLG, SERPINF1
2MP:00053858.1FGF2, PLG, CXCL10, SERPINF1
3MP:00053978.0CXCL10, PLG, HRG, FGF2
4MP:00036318.0SERPINF1, CXCL10, PLG, FGF2
5MP:00053767.7FGF2, HRG, PLG, CXCL10

Publications for Corneal Neovascularization

About this section

Articles related to Corneal Neovascularization:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Corneal Angiography for Guiding and Evaluating Fine-Needle Diathermy Treatment of Corneal Neovascularization. (25841974)
2015
2
Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats. (25853509)
2015
3
Keratocytes Create Stromal Spaces to Promote Corneal Neovascularization Via MMP13 Expression. (25190659)
2014
4
Critical Role of IP-10 on Reducing Experimental Corneal Neovascularization. (25309995)
2014
5
Biometric risk factors for corneal neovascularization associated with hydrogel soft contact lens wear in Korean myopic patients. (25120337)
2014
6
Antiangiogenic Effect of Itraconazole on Corneal Neovascularization: A Pilot Experimental Investigation. (25342430)
2014
7
Clinico-biochemical correlation of the effect of subconjunctival bevacizumab for corneal neovascularization. (25090164)
2014
8
Quantification of corneal neovascularization after ex vivo limbal epithelial stem cell therapy. (25540752)
2014
9
Inhibition of corneal neovascularization by subconjunctival and topical bevacizumab and sunitinib in a rabbit model. (24145627)
2013
10
The inhibitory effect of thalidomide analogue on corneal neovascularization in rabbits. (23739149)
2013
11
Corneal neovascularization: An enigma. (24379562)
2013
12
High-dose topical bevacizumab for corneal neovascularization. (24335191)
2013
13
The effect of different doses of subconjunctival bevacizumab injection on corneal neovascularization. (23404727)
2013
14
Vascular endothelial growth factor inhibitors for treatment of corneal neovascularization: a meta-analysis. (22668582)
2013
15
The association between corneal neovascularization and visual acuity: a systematic review. (22103683)
2013
16
Inhibition of Corneal Neovascularization with the Combination of Bevacizumab and Plasmid Pigment Epithelium-Derived Factor-Synthetic Amphiphile INTeraction-18 (p-PEDF-SAINT-18) Vector in a Rat Corneal Experimental Angiogenesis Model. (23591843)
2013
17
Minocycline inhibits alkali burn-induced corneal neovascularization in mice. (22848638)
2012
18
Corneal neovascularization: an anti-VEGF therapy review. (22898649)
2012
19
Preliminary studies of the effects of vascular adhesion protein-1 inhibitors on experimental corneal neovascularization. (21331460)
2011
20
(-)-Epigallocatechin 3-gallate (EGCG) at the ocular surface inhibits corneal neovascularization. (20971568)
2011
21
Prevention of corneal neovascularization: comparison of different doses of subconjunctival bevacizumab with its topical form in experimental rats. (21212709)
2011
22
The effect of doxycycline temperature-sensitive hydrogel on inhibiting the corneal neovascularization induced by BFGF in rats. (20953876)
2011
23
Potential anti-angiogenic role of Slit2 in corneal neovascularization. (20298689)
2010
24
Inhibition of corneal neovascularization after alkali burn: comparison of different doses of bevacizumab in monotherapy or associated with dexamethasone. (21077280)
2010
25
The effect of bevacizumab on corneal neovascularization in rabbits. (20714387)
2010
26
Inhibition of corneal neovascularization by topical bevacizumab (Anti-VEGF) and Sunitinib (Anti-VEGF and Anti-PDGF) in an animal model. (20591397)
2010
27
Inhibitory effects of bevacizumab on angiogenesis and corneal neovascularization. (18953554)
2009
28
Bevacizumab for corneal neovascularization. (19264217)
2009
29
Corneal neovascularization and ocular irritancy responses in dogs following topical ocular administration of an EP4-prostaglandin E2 agonist. (20008547)
2009
30
Combined use of superficial keratectomy and subconjunctival bevacizumab injection for corneal neovascularization. (18812781)
2008
31
Subconjunctival bevacizumab injection for corneal neovascularization in recurrent pterygium. (18214740)
2008
32
Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization. (17198016)
2007
33
The effect of combinations of flurbiprofen, low molecular weight heparin, and doxycycline on the inhibition of corneal neovascularization. (16783147)
2006
34
Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo. (15851564)
2005
35
Gene expression profile in corneal neovascularization identified by immunology related macroarray. (15547492)
2004
36
Experimental inhibition of corneal neovascularization by endostatin gene transfection in vivo. (14687476)
2003
37
Angiostatin inhibits and regresses corneal neovascularization. (12149060)
2002
38
Lipid hydroperoxide induced corneal neovascularization in hyperglycemic rabbits. (12518243)
2002
39
Impact of short-term versus long-term topical steroids on corneal neovascularization after non-high-risk keratoplasty. (11521696)
2001
40
Photodynamic therapy for corneal neovascularization using topically administered ATX-S10 (Na). (10976562)
2000
41
Topically applied water extract of propolis to suppress corneal neovascularization in rabbits. (10474071)
1999
42
Photodynamic therapy for corneal neovascularization. (9793949)
1998
43
Treatment of corneal neovascularization with argon laser. (8230778)
1993
44
Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat. (2473047)
1989
45
Induction of conjunctival transdifferentiation on vascularized corneas by photothrombotic occlusion of corneal neovascularization. (2459642)
1988
46
Corneal neovascularization in contact lens wearers. (2419272)
1986
47
Corneal effect of isotretinoin: possible exacerbation of corneal neovascularization in a patient with the keratitis, ichthyosis, deafness ("KID") syndrome. (2419373)
1986
48
Experimental corneal neovascularization: biomicroscopic, angiographic, and morphologic correlation. (2419029)
1985-1986
49
The effects of leukocyte depletion on corneal neovascularization. (621924)
1978
50
Argon laser treatment of corneal neovascularization. (4582809)
1973

Variations for Corneal Neovascularization

About this section

Expression for genes affiliated with Corneal Neovascularization

About this section
Search GEO for disease gene expression data for Corneal Neovascularization.

Pathways for genes affiliated with Corneal Neovascularization

About this section

Pathways related to Corneal Neovascularization according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3HRG, PLG
29.3HRG, PLG
3
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.0FGF2, PLG
49.0FGF2, PLG
59.0FGF2, PLG
6
Show member pathways
8.6SERPINF1, PLG, FGF2

Compounds for genes affiliated with Corneal Neovascularization

About this section

Compounds related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 26)
idCompoundScoreTop Affiliating Genes
1epsilon aminocaproic acid439.7PLG, HRG
2kininogen439.6HRG, PLG
3dermatan sulfate439.4FGF2, HRG
4infliximab43 49 1211.4FGF2, CXCL10
5fumagillin43 59 1211.4FGF2, PLG
6alginate439.4FGF2, PLG
7nacl439.3HRG, PLG
8chondroitin sulfate43 2410.3FGF2, HRG
9gefitinib43 49 1211.3PLG, FGF2
10hydrocortisone43 2 59 1212.2FGF2, CXCL10
11thalidomide43 49 59 1212.2FGF2, PLG
12bromodeoxyuridine439.1FGF2, PLG
13glycosaminoglycan439.0FGF2, CXCL10, SERPINF1
14nitric oxide43 24 1211.0SERPINF1, CXCL10, PLG
15heparan sulfate43 249.9FGF2, HRG, CXCL10
16dexamethasone43 49 28 1211.9FGF2, CXCL10, SERPINF1
17suramin43 28 1210.9CXCL10, PLG, FGF2
18thymidine43 249.8FGF2, PLG, CXCL10
19cysteine438.8SERPINF1, PLG, HRG
20retinoic acid43 249.7FGF2, CXCL10, SERPINF1
21glucose438.6PLG, CXCL10, SERPINF1
22heparin43 28 24 1211.4SERPINF1, PLG, HRG, FGF2
23vegf438.4SERPINF1, CXCL10, PLG, FGF2
24serine438.4SERPINF1, PLG, HRG, FGF2
25tyrosine438.3SERPINF1, CXCL10, PLG, FGF2
26matrigel437.9FGF2, HRG, PLG, CXCL10, SERPINF1

GO Terms for genes affiliated with Corneal Neovascularization

About this section

Cellular components related to Corneal Neovascularization according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.3HRG, PLG
2platelet alpha granule lumenGO:00310939.0HRG, PLG
3extracellular spaceGO:00056158.0SERPINF1, CXCL10, PLG, FGF2
4extracellular regionGO:00055767.5FGF2, HRG, PLG, CXCL10, SERPINF1

Biological processes related to Corneal Neovascularization according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:00519189.5HRG, PLG
2fibrinolysisGO:00427309.4PLG, HRG
3platelet activationGO:00301689.3HRG, PLG
4negative regulation of blood vessel endothelial cell migrationGO:00435379.2FGF2, HRG
5platelet degranulationGO:00025769.2PLG, HRG
6negative regulation of angiogenesisGO:00165259.2HRG, CXCL10, SERPINF1
7negative regulation of cell growthGO:00303088.8FGF2, HRG
8chemotaxisGO:00069358.8CXCL10, HRG, FGF2
9negative regulation of cell proliferationGO:00082858.5FGF2, HRG, PLG

Molecular functions related to Corneal Neovascularization according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00048679.5HRG, SERPINF1
2heparin bindingGO:00082018.3FGF2, HRG, CXCL10

Products for genes affiliated with Corneal Neovascularization

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Corneal Neovascularization

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet