Aliases & Classifications for Corneal Ulcer

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 33MeSH, 38NCIt, 25ICD10
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Corneal Ulcer, Aliases & Descriptions:

Name: Corneal Ulcer 9 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:8463
ICD9CM27 370.00, 370.0
MeSH33 D003320
NCIt38 C50515
ICD1025 H16.0

Summaries for Corneal Ulcer

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Wikipedia:63 Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the... more...

MalaCards based summary: Corneal Ulcer is related to keratoconjunctivitis and keratitis. An important gene associated with Corneal Ulcer is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and A-beta Uptake and Degradation. The drugs sulfacetamide and sulfacetamide sodium and the compounds ilomastat and hcec have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and liver, and related mouse phenotypes are tumorigenesis and skeleton.

Related Diseases for Corneal Ulcer

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Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis31.5CCL11
2keratitis30.7TAT, MMP2, MMP9
3vernal keratoconjunctivitis30.3NGF, MMP9, CCL11
4keratoconus30.1MMP3, MMP2
5pneumonia29.9IL1B, IL10, CCL11
6mycotic corneal ulcer10.6
7perforated corneal ulcer10.5
8eosinophilic gastroenteritis10.5CCL11
9endophthalmitis10.4
10rhinitis10.4CCL11, PRG2
11marginal corneal ulcer10.4
12conjunctivitis10.4
13hypopyon10.4
14hypereosinophilic syndrome10.4PRG2, CCL11
15cataract10.4
16central corneal ulcer10.4
17ring corneal ulcer10.4
18sinusitis10.3PRG2, CCL11
19dermatitis herpetiformis10.3MMP3, CCL11
20spiradenoma10.3MUC5AC, CCL11
21intervertebral disc disease10.3IL1B
22herpes simplex10.3
23atopic keratoconjunctivitis10.3
24bronchitis10.3CCR3, CCL11
25poems syndrome10.3IL1B
26blau syndrome10.3IL1B
27factor vii deficiency10.3MUC5AC, NGF
28pulmonary eosinophilia10.3PRG2, CCR3, CCL11
29keratoconjunctivitis sicca10.3
30influenza10.3
31haemophilus influenzae10.3
32mycobacterium fortuitum10.3
33esophagitis10.2PRG2, CCR3, CCL11
34bullous pemphigoid10.2PRG2, CCL11
35respiratory failure10.2CCL11, CCR3, MUC5AC
36periodontal disease10.2MMP3, MMP2
37kawasaki disease10.2MMP3, MMP9
38atopic dermatitis10.2CCL11, CCR3, NGF
39demyelinating disease10.2NGF, IL10
40relapsing-remitting multiple sclerosis10.2MMP9, IL10
41burns10.2
42keratopathy10.2
43exophthalmos10.2
44cicatricial pemphigoid10.2
45keratomalacia10.2
46ectropion10.2
47entropion10.2
48myopia10.2
49uveitis10.2
50anterior uveitis10.2

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to corneal ulcer

Symptoms for Corneal Ulcer

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Drugs & Therapeutics for Corneal Ulcer

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Drug clinical trials:

Search ClinicalTrials for Corneal Ulcer

Search NIH Clinical Center for Corneal Ulcer

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Corneal Ulcer

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Anatomical Context for Corneal Ulcer

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MalaCards organs/tissues related to Corneal Ulcer:

31
Eye, Bone, Liver, Testes

Animal Models for Corneal Ulcer or affiliated genes

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MGI Mouse Phenotypes related to Corneal Ulcer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IL1B, IL10, MMP2, MMP9
2MP:00053908.0MMP9, MMP2, MMP3, IL10, IL1B
3MP:00053887.6MMP9, MMP2, PRG2, CCR3, CCL11, IL10
4MP:00036317.5NGF, MMP9, MMP2, MMP3, IL10, IL1B
5MP:00053767.0NGF, MUC5AC, MMP9, MMP2, MMP3, CCR3
6MP:00053976.8MMP9, MMP2, MMP3, PRG2, CCR3, CCL11
7MP:00053876.3IL1B, MUC5AC, MMP9, MMP2, MMP3, PRG2

Publications for Corneal Ulcer

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Articles related to Corneal Ulcer:

(show top 50)    (show all 323)
idTitleAuthorsYear
1
Community practice patterns for bacterial corneal ulcer evaluation and treatment. (25536529)
2015
2
The corneal ulcer one-touch study: a simplified microbiological specimen collection method. (25244977)
2014
3
Repositioning of pedicle conjunctival flap performed for refractory corneal ulcer. (24669154)
2014
4
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
5
Cost evaluation of corneal ulcer treatment. (23691700)
2013
6
Evaluation of risk factors for development of corneal ulcer after nonocular surgery in dogs: 14 cases (2009-2011). (23683020)
2013
7
Etiological agents of corneal ulcer: five years prospective study in eastern Nepal. (24047020)
2012
8
Bilateral corneal ulceration in keratoconus. (23034295)
2012
9
Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea. (22531699)
2012
10
Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). (21987582)
2012
11
Role of voriconazole in combined acanthamoeba and fungal corneal ulcer. (21733740)
2011
12
Late-onset Klebsiella oxytoca flap-margin-related corneal ulcer following laser in situ keratomileusis. (21782101)
2011
13
Efficacy and safety of bromfenac for the treatment of corneal ulcer pain. (20845001)
2010
14
Corneal ulceration due to vitamin A deficiency in Zellweger syndrome. (19541270)
2009
15
Use of grid keratotomy for the treatment of indolent corneal ulcer in a llama. (17494370)
2007
16
Isolation, vancomycin resistance and biofilm production of Staphylococcus epidermidis from patients with conjunctivitis, corneal ulcers, and endophthalmitis. (18293657)
2006
17
Fungal keratitis in patients with corneal ulcer in Sari, Northern Iran. (16859055)
2006
18
Corneal ulcer in a young child with autosomal recessive epidermolysis bullosa. (17162976)
2006
19
Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses. (16178841)
2005
20
Aeromonas sobria corneal ulcer. (12579184)
2003
21
Active form of gelatinases in tear fluidin patients with corneal ulcer or ocular burn. (12967855)
2003
22
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
23
Serratia Marcescens corneal ulcer as a complication of orthokeratology. (11476690)
2001
24
Multilayer vs. monolayer amniotic membrane transplantation for deep corneal ulcer treatment. (11817009)
2001
25
Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis--a case report of corneal ulcer. (9348738)
1997
26
Corneal ulcer associated with contamination of aerosol saline spray tip. (9439366)
1997
27
Therapy-resistant corneal ulcer in a six-year old patient. (9009360)
1996
28
Corneal ulcer in a child caused by Nocardia asteroides following corneal perforation. (7752036)
1995
29
History and clinical signs. Bilateral exophthalmos, and left lagophthalmos and corneal ulceration. (7648545)
1995
30
Corneal ulceration in a patient with alpha 1 antitrypsin deficiency. (7918295)
1994
31
CMDBS, functional analogue of heparin sulfate as a new class of corneal ulcer healing agents. (7536320)
1994
32
Human infectious corneal ulcer caused by Pythium insidiosum. (8458239)
1993
33
Isolation of Kingella kingae from a corneal ulcer. (1401031)
1992
34
Pseudomonas corneal ulcer associated with rigid, gas-permeable, daily-wear lenses in a patient infected with human immunodeficiency virus. (1543232)
1992
35
Acinetobacter corneal ulcer after penetrating keratoplasty. (2658621)
1989
36
Topical antibiotics in the management of corneal ulcer. (3069735)
1988
37
Pseudomonas aeruginosa corneal ulcer associated with an aerosol can of preservative-free saline. Case report. (3142448)
1988
38
Spontaneous fungal corneal ulcer as an ocular manifestation of AIDS. (3631189)
1987
39
A new rapid immunoperoxidase diagnostic staining of herpes simplex virus 1 indolent corneal ulcer. (6100242)
1984
40
Pseudomonas corneal ulcer treated by full-thickness graft in a lamellar bed. (7018342)
1981
41
Lysozyme in corneal ulcer. (1200558)
1975
42
Colistin and genticyn in the treatment of Pseudomonas corneal ulcer. (4429309)
1974
43
Hypopyon corneal ulcers in rural Bengal. (4401770)
1972
44
Corneal ulcer due to Pseudomonas aeruginosa. A comparison of the disease in California and El Salvador. (4995262)
1971
45
Corneal ulcer and its management. (5446075)
1970
46
Corneal ulcer. (13110464)
1953
47
B. pyocyaneus corneal ulcer treated with penicillin. (18872482)
1948
48
A case of corneal ulcer treated with penicillin solution. (20285503)
1947
49
Corneal ulcer. (20997126)
1946
50
Treatment of corneal ulcer. (20273942)
1946

Variations for Corneal Ulcer

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Expression for genes affiliated with Corneal Ulcer

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Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for genes affiliated with Corneal Ulcer

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Pathways related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP9, MMP3
29.6MMP9, MMP2
39.6MMP9, MMP2
49.6MMP9, MMP2
59.6MMP2, MMP9
69.6MMP2, MMP9
79.6MMP9, MMP2
89.3IL10, IL1B
99.3IL10, IL1B
109.3IL10, IL1B
119.3IL10, IL1B
129.3IL1B, IL10
13
Show member pathways
9.3MMP3, MMP2, MMP9
14
Show member pathways
Metalloproteases in connective tissue degradation
9.3MMP9, MMP2, MMP3
15
Show member pathways
9.3MMP3, MMP2, MMP9
169.2IL1B, MMP3, MMP9
179.0IL1B, IL10, NGF
18
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9IL1B, IL10, MMP9
19
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.9MMP2, IL10, IL1B
20
Show member pathways
8.8NGF, MMP9, MMP3, CCR3, CCL11
21
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.8NGF, MMP9, MMP2, IL1B
22
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
23
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
24
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
25
Show member pathways
8.2PRG2, CCL11, IL10, IL1B
26
Show member pathways
7.9PRG2, CCR3, CCL11, IL10, IL1B
27
Show member pathways
7.8CCL11, CCR3, PRG2, MMP3, MMP2, MMP9

Compounds for genes affiliated with Corneal Ulcer

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Compounds related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1ilomastat439.6MMP3, MMP2, MMP9
2hcec439.6NGF, MMP2, MMP3
3latanoprost43 1210.6MMP3, MMP2, MMP9
4(4-aminophenyl)mercuric acetate439.5MMP3, MMP2, MMP9
5gm 6001599.4MMP9, MMP2, MMP3
6uk 383367599.4MMP9, MMP3, MMP2
7gi 254023x599.3MMP3, MMP2, MMP9
8doxycycline43 1210.2TAT, MMP3, MMP9, MMP2
9pdtc439.1NGF, MMP9, IL1B, MMP2
10celecoxib43 59 28 49 24 1214.0IL1B, MMP3, MMP2, MMP9
11butyrate439.0MMP9, CCR3, MMP3, TAT, CCL11
12matrigel439.0NGF, MMP9, MMP2, CCL11, MMP3
13hydroxamate439.0MMP2, MMP3, MMP9
14ibuprofen43 28 49 24 1212.9IL1B, IL10, MMP3, MMP2
15pentoxifylline43 129.9MMP2, IL1B, TAT, IL10
16troglitazone43 28 59 1211.9IL1B, MMP2, MMP3, MMP9, CCL11
17hyaluronic acid43 249.8MMP3, IL1B, CCL11, MMP9, MMP2
18ivig438.8IL10, MMP2, MMP9, IL1B
19prostaglandin438.8IL1B, MUC5AC, MMP9, MMP3, CCL11
20hematoxylin438.7MUC5AC, MMP3, PRG2, MMP9
21hydrocortisone43 2 59 1211.7TAT, IL1B, IL10, MMP2
22herbimycin a43 599.6NGF, CCR3, MMP2, IL1B, CCL11, MMP9
23prednisolone43 28 1210.5MMP3, MMP2, TAT, IL10, CCL11, NGF
24ribonucleic acid438.5MUC5AC, MMP9, MMP3, IL1B, MMP2
25cyclosporin a43 28 5910.5MMP9, MMP3, CCL11, TAT, IL10, NGF
26tgf beta1438.5MMP3, IL1B, IL10, MMP2, MMP9
27thymidine43 249.4NGF, CCR3, IL10, IL1B, CCL11
28ccl343 289.4MMP9, IL1B, CCR3, CCL11, TAT, IL10
29alanine438.4NGF, MMP9, MMP2, MMP3, CCR3, CCL11
30n acetylcysteine438.3IL1B, CCL11, MMP3, MMP2, MMP9, MUC5AC
31paraffin438.3MUC5AC, MMP9, IL10, MMP3, MMP2
32pd 98,059438.3NGF, MMP2, MMP9, MMP3, IL1B, MUC5AC
33ly294002438.3IL10, CCL11, IL1B, MMP2, MMP9, NGF
34indomethacin43 28 59 1211.2IL1B, TAT, PRG2, MMP3, NGF, CCL11
35rantes438.0CCR3, CCL11, IL10, IL1B, MMP3, MMP9
36actinomycin d437.9CCL11, TAT, IL1B, NGF, MMP9, PRG2
37cycloheximide437.9NGF, MMP2, MMP3, TAT, MMP9, IL1B
38oxygen43 248.8MUC5AC, MMP3, TAT, CCL11, CCR3, PRG2
39pge2437.7IL1B, IL10, CCL11, MMP3, MMP2, MMP9
40methotrexate49 43 129.7IL1B, MUC5AC, MMP9, MMP3, IL10, MMP2
41vegf437.6TAT, IL10, CCL11, IL1B, MMP2, NGF
42sb 20358043 598.5MMP9, CCL11, MMP2, MMP3, MUC5AC, NGF
43estrogen437.4TAT, MMP9, MMP2, MMP3, PRG2, MUC5AC
44cysteine437.3MMP2, MMP9, PRG2, MMP3, MUC5AC, NGF
45calcium43 49 24 1210.3MMP9, MUC5AC, MMP2, MMP3, PRG2, CCR3
46dexamethasone43 49 28 1210.2NGF, MMP3, TAT, IL1B, CCL11, MUC5AC
47genistein43 28 59 2 24 1212.1CCL11, CCR3, MMP2, MMP3, MMP9, PRG2
48tyrosine437.1NGF, MMP3, MUC5AC, MMP9, MMP2, TAT
49histamine43 28 248.8MMP3, CCR3, CCL11, PRG2, MUC5AC, IL10
50retinoic acid43 247.6TAT, IL1B, CCL11, CCR3, PRG2, MMP3

GO Terms for genes affiliated with Corneal Ulcer

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Cellular components related to Corneal Ulcer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.3MMP3, MMP2, MMP9
2extracellular spaceGO:00056157.4IL1B, NGF, MMP9, MMP2, MMP3, CCL11
3extracellular regionGO:00055767.0NGF, MMP9, MMP2, MMP3, PRG2, CCL11

Biological processes related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:000931410.0CCL11, NGF
2extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7NGF, IL1B
3cellular response to amino acid stimulusGO:00712309.6MMP3, MMP2
4positive regulation of angiogenesisGO:00457669.6IL1B, CCL11, CCR3
5collagen catabolic processGO:00305749.5MMP3, MMP2, MMP9
6response to glucocorticoidGO:00513849.4NGF, IL10, TAT
7extracellular matrix disassemblyGO:00226179.4MMP3, MMP2, MMP9
8proteolysisGO:00065089.4MMP9, MMP2, MMP3
9embryo implantationGO:00075669.3IL1B, MMP2, MMP9
10positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.2NGF, IL10, IL1B
11extracellular matrix organizationGO:00301989.0MMP3, MMP2, MMP9
12immune responseGO:00069558.8IL1B, CCL11, PRG2
13inflammatory responseGO:00069548.7IL1B, IL10, CCL11, CCR3, NGF

Molecular functions related to Corneal Ulcer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.3MMP3, MMP2, MMP9

Products for genes affiliated with Corneal Ulcer

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Sources for Corneal Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet