MCID: CRN028
MIFTS: 46

Corneal Ulcer malady

Eye category

Summaries for Corneal Ulcer

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the... more...

MalaCards: Corneal Ulcer is related to uveitis and vernal keratoconjunctivitis. An important gene associated with Corneal Ulcer is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Degradation of collagen and A-beta Plaque Formation & APP Metabolism . The drugs sulfacetamide and sulfisoxazole diolamine and the compounds cycloheximide and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and respiratory system.

Aliases & Classifications for Corneal Ulcer

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

corneal ulcer 8 45 61


External Ids:

Disease Ontology8 DOID:8463
ICD9CM27 370.00, 370.0
MeSH35 D003320
NCIt40 C50515
ICD1025 H16.0

Related Diseases for Corneal Ulcer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Corneal Ulcer family:

central corneal ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.2CCL11, IL10
2vernal keratoconjunctivitis29.9CCL11, NGF, MMP9
3mycotic corneal ulcer10.6
4perforated corneal ulcer10.5
5marginal corneal ulcer10.4
6corneal disease10.3
7ring corneal ulcer10.3
8hypopyon ulcer10.3
9central corneal ulcer10.3
10atopic keratoconjunctivitis10.3
11keratoconjunctivitis sicca10.2
12mycobacterium fortuitum10.2
13graft versus host disease10.1
14cicatricial pemphigoid10.1
15exophthalmos10.1
16lymphedema-distichiasis syndrome10.1
17anterior uveitis10.1
18klebsiella10.1
19epidermolysis bullosa dystrophica, ar10.1
20tarsal kink syndrome10.1
21pilomatrixoma10.0
22sjogren-larsson syndrome10.0
23barre-lieou syndrome10.0
24goldenhar syndrome10.0
25rosacea10.0
26xerophthalmia10.0
27type vi ehlers-danlos syndrome10.0
28junctional epidermolysis bullosa10.0
29ladd syndrome10.0
30cicatricial ectropion10.0
31keratomalacia10.0
32orbital cellulitis10.0
33cellulitis10.0
34aniridia10.0
35anhidrosis10.0
36bullous keratopathy10.0
37pharyngitis10.0
38zellweger syndrome10.0
39acute dacryocystitis10.0
40vernal conjunctivitis10.0
41chronic dacryocystitis10.0
42actinomycosis10.0
43herpes zoster10.0
44cocaine abuse10.0
45acrodermatitis enteropathica10.0
46epidermolysis bullosa dystrophica10.0
47riley-day syndrome10.0
48recurrent corneal erosion10.0
49corneal abscess10.0
50acrocephalosyndactylia10.0

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to corneal ulcer

Clinical Features for Corneal Ulcer

Drugs & Therapeutics for Corneal Ulcer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Corneal Ulcer

Drug clinical trials:

Search ClinicalTrials for Corneal Ulcer

Search NIH Clinical Center for Corneal Ulcer

Search CenterWatch for Corneal Ulcer

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Corneal Ulcer

Anatomical Context for Corneal Ulcer

Animal Models for Corneal Ulcer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Corneal Ulcer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.1MUC5AC, NGF, CCR3
2MP:00053888.5CCL11, PRG2, MMP2, MMP9
3MP:00053876.3MMP9, CCL11, CCR3, PRG2, MUC5AC, IL10

Publications for Corneal Ulcer

Sources:
51PubMed
See all sources

Articles related to Corneal Ulcer:

(show top 50)    (show all 332)
idTitleAuthorsYear
1
A clinical microbiological study of corneal ulcer patients at western Gujarat, India. (23852845)
2013
2
Matrix metalloproteinases (MMP-2 and MMP-9) activity in corneal ulcer and ocular surface disorders determined by gelatin zymography. (24376903)
2012
3
Streptococcal pharyngitis leading to corneal ulceration. (22360434)
2012
4
Neurotrophic corneal ulcer after topical tetracaine abuse: management guidelines. (22946020)
2011
5
Pattern of fungal isolates in cases of corneal ulcer in the western periphery of Nepal. (21876583)
2011
6
UV-A Collagen Cross-Linking Treatment of Bullous Keratopathy Combined With Corneal Ulcer. (20023590)
2010
7
Streptococcus bovis causing perforating corneal ulcer. (19092424)
2009
8
Comparison of topical fixed-combination fortified vancomycin-amikacin (VA solution) to conventional separate therapy in the treatment of bacterial corneal ulcer. (18188174)
2009
9
Regression of severe corneal stromal neovascularization with topical cyclosporine 0.05% after penetrating keratoplasty for fungal corneal ulcer. (18094939)
2009
10
Contact Lens Induced Corneal Ulcer Management in a Tertiary Eye Unit in Oman - A descriptive study. (21748073)
2008
11
Efficacy of fluconazole subconjunctival injection as adjunctive therapy for severe recalcitrant fungal corneal ulcer. (18575282)
2008
12
Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient. (17885942)
2008
13
Sterile corneal ulcer with ring infiltrate and hypopyon after recurrent erosions. (16980934)
2007
14
Corneal tattooing to mask subsequent opacification after amniotic membrane grafting for stromal corneal ulcer. (16965504)
2006
15
Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses. (16178841)
2005
16
Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report. (15448501)
2004
17
Aeromonas sobria corneal ulcer. (12579184)
2003
18
Tarsal kink syndrome associated with congenital corneal ulcer. (12544799)
2003
19
Indolent corneal ulcers in a patient with congenital insensitivity to pain with anhidrosis: a case report and literature review. (11936447)
2002
20
Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study. (12090097)
2002
21
Corneal ulcer caused by the new fungal species Sarcopodium oculorum. (12149384)
2002
22
Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study. (12090098)
2002
23
Multilayer vs. monolayer amniotic membrane transplantation for deep corneal ulcer treatment. (11817009)
2001
24
Diagnostic ophthalmology. Melting corneal ulcer. (11519280)
2001
25
Nigrospora causing corneal ulcer--a case report. (9444870)
1997
26
Corneal ulcer in a child caused by Nocardia asteroides following corneal perforation. (7752036)
1995
27
Excimer laser phototherapeutic keratectomy for shield ulcers and corneal plaques in vernal keratoconjunctivitis. (7641046)
1995
28
Pseudomonas aeruginosa corneal ulcer isolates distinguished using the arbitrarily primed PCR DNA fingerprinting method. (7851113)
1994
29
Eosinophil granule major basic protein deposition in corneal ulcers associated with vernal keratoconjunctivitis. (8488918)
1993
30
Alcaligenes faecalis corneal ulcer in a patient with cicatricial pemphigoid. (8430740)
1993
31
An emergency corneal ulcer kit. (1816732)
1991
32
Serum and tear immunoglobulins in bacterial, fungal and viral corneal ulcers. (2336937)
1990
33
Keratoconjunctivitis sicca and corneal ulcers. (2328584)
1990
34
Acinetobacter corneal ulcer after penetrating keratoplasty. (2658621)
1989
35
Achromobacter xylosoxidans corneal ulcer in a therapeutic soft contact lens wearer. (2805715)
1989
36
Actinomycetic corneal ulcer. (2606221)
1989
37
Topical antibiotics in the management of corneal ulcer. (3069735)
1988
38
Corneal perforation in Mooren's ulcer--immunological and clinical follow-up. (3262556)
1988
39
Nocardia asteroides as a cause of corneal ulcer. Case report. (3551895)
1987
40
Surgical therapy of a Pseudomonas corneal ulcer in a diabetic. (3113316)
1987
41
Herpetic corneal ulcer following radial keratotomy. (6402972)
1983
42
Marginal corneal ulcer due to beta-streptococcus. (843277)
1977
43
Colistin and genticyn in the treatment of Pseudomonas corneal ulcer. (4429309)
1974
44
Hypopyon corneal ulcers in rural Bengal. (4401770)
1972
45
An intractable corneal ulcer (a case report). (4668487)
1972
46
Marginal (ring) corneal ulcer as presenting manifestation of Wegener's granuloma. A clinicopathologic study. (5493412)
1970
47
Mycobacterium fortuitum corneal ulcer. (5903802)
1966
48
Anaerobic actinomycosis bovis corneal ulcer. (13898747)
1962
49
Corneal ulcer produced by Aerobacter aerogenes. (14799012)
1951
50
B. pyocyaneus corneal ulcer treated with penicillin. (18872482)
1948

Genetic Variations for Corneal Ulcer

Expression for genes affiliated with Corneal Ulcer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Corneal Ulcer

Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for genes affiliated with Corneal Ulcer

Sources:
54Reactome, 53R&D Systems, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Corneal Ulcer

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Corneal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5TAT
2(4-aminophenyl)mercuric acetate4510.4MMP3
3matrigel4510.2MMP3, CCL11
4rantes4510.2IL1B, CCL11
5butyrate4510.2CCL11, CCR3
6cyclosporin a45 29 6012.0NGF, CCL11, TAT
7hydrocortisone45 2 60 1112.9TAT, MMP2
8hematoxylin459.9MMP3, PRG2
9pge2459.8CCL11, MMP2, MMP9
10ilomastat459.7MMP3, MMP2, MMP9
11latanoprost45 1110.7MMP2, MMP3, MMP9
12hcec459.7MMP2, MMP3, NGF
13indomethacin45 60 29 1112.6PRG2, NGF, TAT
14uk 383367609.6MMP3, MMP2, MMP9
15gi 254023x609.6MMP3, MMP2, MMP9
16gm 6001609.6MMP2, MMP3, MMP9
17hydroxamate459.5MMP9, MMP2, MMP3
18marimastat45 60 1111.4MMP9, MMP2, MMP3
19doxycycline45 1110.4TAT, MMP9, MMP2, MMP3
20pdtc459.3MMP9, NGF, IL1B, MMP2
21celecoxib45 60 29 50 11 2414.2MMP9, MMP2, MMP3, IL1B
22groalpha459.2IL1B, IL10, CCL11
23ciglitazone45 2910.1IL1B, MMP2, MMP9
24ibuprofen45 29 50 11 2413.1MMP2, IL1B, IL10, MMP3
25pentoxifylline45 1110.1MMP2, TAT, IL1B, IL10
26troglitazone45 29 60 1112.1MMP9, MMP2, MMP3, IL1B, CCL11
27hyaluronic acid45 2410.0IL1B, MMP3, CCL11, MMP2, MMP9
28herbimycin a45 609.8IL1B, MMP9, CCL11, MMP2, NGF, CCR3
29dexamethasone45 50 29 1111.8TAT, CCL11, CCR3, MUC5AC, MMP9
30tgf beta1458.8MMP9, IL10, MMP3, MMP2, IL1B
31prednisolone45 29 1110.8MMP3, CCL11, NGF, IL10, TAT, MMP2
32ccl345 299.7CCL11, TAT, CCR3, MMP9, IL10, IL1B
33curcumin458.6MMP9, MMP3, IL1B, MMP2
34prostaglandin458.6IL1B, MUC5AC, MMP9, MMP3, CCL11
35ly294002458.6NGF, IL10, CCL11, MMP9, IL1B, MMP2
36alanine458.5CCL11, MMP9, CCR3, NGF, TAT, MMP3
37ribonucleic acid458.4IL1B, MMP9, MMP2, MMP3, MUC5AC
38actinomycin d458.3NGF, TAT, MMP9, IL1B, CCL11, CCR3
39n acetylcysteine458.2CCL11, MMP2, MMP3, MMP9, IL1B, MUC5AC
40pd 98,059458.2MMP3, MUC5AC, MMP9, MMP2, IL1B, NGF
41paraffin458.1MMP3, IL10, MMP2, MMP9, MUC5AC
42vegf457.9MMP9, NGF, IL10, IL1B, CCL11, TAT
43methotrexate45 50 119.7MMP2, MUC5AC, IL10, MMP9, TAT, IL1B
44genistein45 29 60 2 11 2412.5MMP9, MMP2, MMP3, TAT, IL1B, NGF
45sb 20358045 608.5CCL11, IL1B, MUC5AC, IL10, MMP3, MMP9
46cysteine457.4MMP2, CCR3, PRG2, NGF, MUC5AC, TAT
47tyrosine457.1PRG2, CCR3, CCL11, MUC5AC, TAT, MMP3
48calcium45 50 11 2410.1MMP2, MMP3, MUC5AC, NGF, PRG2, CCR3
49histamine45 29 249.0IL1B, CCL11, CCR3, PRG2, NGF, MMP3
50retinoic acid45 247.7MMP3, MMP9, MUC5AC, TAT, MMP2, NGF

GO Terms for genes affiliated with Corneal Ulcer

Sources:
16Gene Ontology
See all sources

Cellular components related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7CCL11, PRG2, NGF, IL1B, MMP3, MMP2
2extracellular spaceGO:0056157.2CCL11, CCR3, NGF, IL10, IL1B, MMP3

Biological processes related to Corneal Ulcer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.1CCR3, CCL11
2response to radiationGO:0093149.9NGF, CCL11
3eosinophil chemotaxisGO:0482459.8CCR3, CCL11
4ERK1 and ERK2 cascadeGO:0703719.6CCR3, CCL11
5collagen catabolic processGO:0305749.5MMP3, MMP2, MMP9
6response to glucocorticoid stimulusGO:0513849.5TAT, IL10, NGF
7embryo implantationGO:0075669.5IL1B, MMP2, MMP9
8positive regulation of angiogenesisGO:0457669.5CCL11, CCR3, IL1B
9extracellular matrix disassemblyGO:0226179.4MMP9, MMP2, MMP3
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL1B, IL10, NGF
11inflammatory responseGO:0069548.9IL1B, IL10, NGF, CCR3, CCL11

Molecular functions related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.4MMP9, MMP2, MMP3

Products for genes affiliated with Corneal Ulcer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corneal Ulcer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet