Aliases & Classifications for Corneal Ulcer

MalaCards integrated aliases for Corneal Ulcer:

Name: Corneal Ulcer 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8463
ICD10 32 H16.0 H16.00
ICD9CM 34 370.0 370.00
MeSH 41 D003320
NCIt 46 C50515
UMLS 69 C0010043

Summaries for Corneal Ulcer

MalaCards based summary : Corneal Ulcer is related to keratoconjunctivitis sicca and vernal keratoconjunctivitis. An important gene associated with Corneal Ulcer is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Miconazole and Natamycin have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and testes, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the... more...

Related Diseases for Corneal Ulcer

Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis sicca 30.1 IL1B NGF
2 vernal keratoconjunctivitis 29.8 CCL11 MMP9
3 keratoconus 29.3 MMP2 MMP3 MMP9
4 arthritis 29.1 IL1B MMP3 MMP9
5 perforated corneal ulcer 12.2
6 central corneal ulcer 12.2
7 mycotic corneal ulcer 12.2
8 marginal corneal ulcer 12.2
9 ring corneal ulcer 12.2
10 corneal dystrophy, lattice type i 10.9
11 lymphedema-distichiasis syndrome 10.9
12 tyrosinemia, type ii 10.9
13 barre-lieou syndrome 10.9
14 ichthyosis follicularis atrichia photophobia syndrome 10.9
15 neurotrophic keratopathy 10.9
16 keratomalacia 10.6
17 extracranial arteriovenous malformation 10.4 MMP2 MMP9
18 focal myositis 10.4 MMP2 MMP9
19 lentigo maligna melanoma 10.4 MMP2 MMP9
20 villous adenocarcinoma 10.4 MMP2 MMP9
21 psammomatous meningioma 10.4 MMP2 MMP9
22 acute transverse myelitis 10.4 MMP2 MMP9
23 senile ectropion 10.4 MMP2 MMP9
24 internal hemorrhoid 10.4 MMP2 MMP9
25 chronic follicular conjunctivitis 10.4 IL1B MMP9
26 parotitis 10.4 MMP2 MMP9
27 light chain deposition disease 10.4 MMP2 MMP9
28 microcystic meningioma 10.4 MMP2 MMP9
29 klatskin's tumor 10.4 MMP2 MMP9
30 hypercementosis 10.4 MMP2 MMP9
31 nasal cavity squamous cell carcinoma 10.3 MMP2 MMP9
32 odontogenic myxoma 10.3 MMP2 MMP9
33 transverse myelitis 10.3 MMP2 MMP9
34 periapical periodontitis 10.3 IL1B MMP9
35 lung giant cell carcinoma 10.3 MMP2 MMP9
36 chromoblastomycosis 10.3 CCR1 MMP9
37 burning mouth syndrome 10.3 IL1B NGF
38 jejunoileitis 10.3 IL1B NGF
39 chronic meningitis 10.3 CCL11 MMP9
40 angiostrongyliasis 10.3 CCL11 MMP9
41 paine syndrome 10.3 IL1B NGF
42 blepharitis 10.3 CCL11 MMP9
43 eosinophilic meningitis 10.3 CCL11 MMP9
44 rheumatoid nodulosis 10.2 MMP3 MMP9
45 hypertensive heart disease 10.2 MMP2 MMP9
46 central nervous system tuberculosis 10.2 IL1B MMP9
47 gingival hypertrophy 10.2 MMP3 MMP9
48 squamous cell carcinoma of the hypopharynx 10.2 MMP3 MMP9
49 blepharochalasis 10.2 MMP3 MMP9
50 conjunctival nevus 10.2 MMP2 MMP9 NGF

Comorbidity relations with Corneal Ulcer via Phenotypic Disease Network (PDN):


Bullous Keratopathy Cicatricial Pemphigoid
Hypertension, Essential Hypopyon Ulcer
Perforated Corneal Ulcer Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to Corneal Ulcer

Symptoms & Phenotypes for Corneal Ulcer

MGI Mouse Phenotypes related to Corneal Ulcer:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CCL11 CCR1 CCR3 DHX9 IL1B MMP2
2 immune system MP:0005387 9.56 CCL11 CCR1 CCR3 DHX9 IL1B MMP2
3 respiratory system MP:0005388 9.02 CCL11 CCR1 CCR3 MMP2 MMP9

Drugs & Therapeutics for Corneal Ulcer

Drugs for Corneal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 179)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
2
Natamycin Approved Phase 4,Phase 3,Phase 1,Phase 2 7681-93-8 5281099
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Ephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 299-42-3 9294
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
6
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 151096-09-2, 354812-41-2 152946
7
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 90-82-4 7028
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
9
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
10
Amphotericin B Approved, Investigational Phase 4 1397-89-3 5280965 14956
11
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 83-88-5 493570
12 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2
13 Central Nervous System Depressants Phase 4,Phase 3
14 Mitogens Phase 4,Phase 2,Phase 1
15 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1
16 Vasoconstrictor Agents Phase 4,Phase 3,Phase 1,Phase 2
17 Anesthetics Phase 4,Phase 3,Phase 1
18 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
19 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
20 Anesthetics, Local Phase 4,Phase 3
21 Hormones Phase 4,Phase 3,Phase 1,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
23 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
24 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
25 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
26 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Antifungal Agents Phase 4,Phase 3,Phase 1,Phase 2
28 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1
29 Protective Agents Phase 4,Phase 3,Phase 2
30 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1
31 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
32 Antiparasitic Agents Phase 4,Phase 2,Phase 3
33 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2
34 Prednisolone acetate Phase 4,Phase 3
35 Dexamethasone acetate Phase 4 1177-87-3
36 glucocorticoids Phase 4,Phase 3,Phase 2
37
protease inhibitors Phase 4
38 Methylprednisolone acetate Phase 4,Phase 3
39 Methylprednisolone Hemisuccinate Phase 4,Phase 3
40 Nasal Decongestants Phase 4,Phase 3,Phase 1,Phase 2
41 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Cyclosporins Phase 4,Phase 1
43 HIV Protease Inhibitors Phase 4
44 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3,Phase 2
45 Dermatologic Agents Phase 4,Phase 1,Phase 2
46 Antiemetics Phase 4,Phase 3
47 Prednisolone hemisuccinate Phase 4,Phase 3
48 Immunosuppressive Agents Phase 4,Phase 2
49 Prednisolone phosphate Phase 4,Phase 3
50 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 63)

# Name Status NCT ID Phase Drugs
1 Steroids for Corneal Ulcers Trial Completed NCT00324168 Phase 4 Antibiotics;Topical corticosteroid;Placebo
2 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
3 Cross-linking for Corneal Ulcers Treatment Trial Recruiting NCT02570321 Phase 4
4 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
5 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
6 Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3 Doxycycline;Placebo
7 Mycotic Ulcer Treatment Trial I Completed NCT00996736 Phase 3 Natamycin;Voriconazole
8 The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo Completed NCT00997035 Phase 3 Voriconazole;Placebo
9 Comparison Between Bandage Contact Lens and Pressure Patching for The Erosion Area and Pain Scale in Corneal Erosion Patients Completed NCT01809483 Phase 3
10 Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis Recruiting NCT02717871 Phase 3 Cefazolin in combination with either tobramycin or gentamicin;Cycloplegic agents (cyclopentolate 1% eye drops);Fluoroquinolones (Besifloxacin ; ciprofloxacin ; gatifloxacin ; levofloxacin ; moxifloxacin ; ofloxacin );Corticosteroids (prednisolone acetate 0.5% or 1% eye drops)
11 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Active, not recruiting NCT01794312 Phase 3
12 Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood Enrolling by invitation NCT02153515 Phase 3
13 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Enrolling by invitation NCT02731638 Phase 3 Intrastromal voriconazole;Natamycin
14 A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine Terminated NCT00516399 Phase 3 povidone-iodine 1.25% ophthalmic solution;natamycin ophthalmic suspension, USP 5%
15 Effect of Tetracaine on Pain Management and Corneal Healing in Patients With Acute Corneal Abrasion Terminated NCT02483897 Phase 3 Tetracaine 0.5% ophthalmic drops;Normal Saline placebo drops
16 Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease Withdrawn NCT01753596 Phase 3
17 Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 Neurotrophic Keratitis Unknown status NCT02227147 Phase 2 rhNGF 20µg/ml;Placebo Vehicle
18 A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers Completed NCT00386958 Phase 2 Povidone-Iodine
19 Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers Completed NCT00651586 Phase 2 Gatifloxacin 0.3% ophthalmic solution;Ciprofloxacin 0.3% ophthalmic solution
20 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed NCT01756456 Phase 1, Phase 2 rhNGF 10 µg/ml eye drops solution;rhNGF 20 µg/ml eye drops solution;Placebo
21 Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer Completed NCT00557362 Phase 1, Phase 2 Natamycin 5%;Voriconazole
22 Collagen Cross-linking in Infectious Keratitis Trial Completed NCT01831206 Phase 2
23 Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye Completed NCT01393132 Phase 2 Thymosin Beta 4 eye drops;Vehicle Control
24 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis Completed NCT01582880 Phase 1, Phase 2 Riboflavin
25 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
26 NSAID Phase II for Non-central Involved Diabetic Macular Edema (DME) Completed NCT01331005 Phase 2 nepafenac 0.1% drops
27 Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment Recruiting NCT01765244 Phase 1, Phase 2
28 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2 Infliximab;Cyclophosphamide
29 A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers. Terminated NCT01928693 Phase 2 Besivance 0.6% Ophthalmic Suspension;Zymaxid 0.5% Ophthalmic Solution;Vigamox 0.5% Ophthalmic Solution
30 Infliximab to Improve Retention of the Boston Keratoprosthesis in Patients After Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis (SJS/TENS) Withdrawn NCT01256489 Phase 1, Phase 2 Infliximab
31 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
32 Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01075347 Phase 1
33 Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries Completed NCT01031888 Phase 1 Topical insulin eye drops;Conventional postoperative eye drops
34 Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions Completed NCT00396188 Phase 1
35 A Study of FPA144 Combined With Modified FOLFOX6 in Gastric/Gastroesophageal Cancer Recruiting NCT03343301 Phase 1
36 Topical Infliximab for Sterile Corneal Melt Recruiting NCT02987686 Phase 1 Topical Infliximab
37 Xenogenic Keratoplasty From Porcine Cornea Suspended NCT01443559 Phase 1
38 The Application of Fibrin Glue in Ocular Surface Diseases Withdrawn NCT00155402 Phase 1 tissue fibrin glue application (Tisseel)
39 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
40 Corneal Ulcer Prevention Through Health Education Unknown status NCT02284698
41 Transplantation of Acellular Corneal Matrix to Treat Corneal Ulcer Unknown status NCT01244776
42 Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients Unknown status NCT00789646
43 Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis Unknown status NCT02328053 Topical anti-fungal therapy
44 The Asia Cornea Society Infectious Keratitis Study Unknown status NCT01560208
45 Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Unknown status NCT01379833
46 Early Amniotic Membrane Transplantation in Bacterial Keratitis Unknown status NCT02716883
47 Pascal Pascal Dynamic Contour Tonometer (DCT) Intraocular Pressure and Ocular Pulse Amplitude in Patients With Thyroid Related Orbitopathy: A Comparison to Goldmann Tonometer and to Muscles Characteristics on CT Scan Unknown status NCT00646295
48 Spectral-domain Optical Coherence Tomography of the Eye Unknown status NCT02614625
49 Safety and Effectiveness of Collagen-phosphorylcholine Bioengineered Cornea in Patients Requiring Lamellar Keratoplasty Completed NCT02277054
50 Randomized Double Blinded Study Evaluating CACICOL20 Efficiency Versus Placebo Corneal Chronic Ulcers Healing Completed NCT01242839

Search NIH Clinical Center for Corneal Ulcer

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: corneal ulcer

Genetic Tests for Corneal Ulcer

Anatomical Context for Corneal Ulcer

MalaCards organs/tissues related to Corneal Ulcer:

38
Eye, Thyroid, Testes, Liver, Bone

Publications for Corneal Ulcer

Articles related to Corneal Ulcer:

(show top 50) (show all 362)
# Title Authors Year
1
Novel Image-Based Analysis for Reduction of Clinician-Dependent Variability in Measurement of the Corneal Ulcer Size. ( 29256985 )
2018
2
Necessity to identify the causative agent for appropriate treatment in fungal corneal ulcer: an in vitro study. ( 29398639 )
2018
3
Treatment of a Perforated Corneal Ulcer with Tectonic DSAEK: a Case Report. ( 28282693 )
2017
4
CYP1B1 Cytopathy: Uncommon Phenotype of a Homozygous CYP1B1 Deletion as Internal Corneal Ulcer of Von Hippel. ( 28644236 )
2017
5
The Utility of Repeat Culture in Fungal Corneal Ulcer Management: A Secondary Analysis of the MUTT-I Randomized Clinical Trial. ( 28385473 )
2017
6
Risk of corneal ulcer in patients with end-stage renal disease: a retrospective large-scale cohort study. ( 28855193 )
2017
7
Corneal ulcer due to a rare coelomycetes fungus Chaetomium strumarium: Case report and global review of Chaetomium keratomycosis. ( 28905835 )
2017
8
Severe corneal ulcer with progression to endophthalmitis and high-grade bacteremia. ( 29260050 )
2017
9
Long Eyebrow Hair Causing Corneal Ulcer. ( 29157427 )
2017
10
Corneal ulcer due to a rare pleosporalean member of the genus Bipolaris following cow tail injury to the eye: A case report and review of literature. ( 28573998 )
2017
11
Management of a Nonhealing, Superficial Corneal Ulcer in a Hyacinth Macaw (Anodorhynchus hyacinthinus). ( 28891697 )
2017
12
An unusual case of spontaneous Mycobacterium chelonae corneal ulcer in a healthy middle-aged adult [Retraction]. ( 28769591 )
2017
13
Treatment Results of Corneal Collagen Cross-Linking Combined with Riboflavin and 440 Nm Blue Light for Bacterial Corneal Ulcer in Rabbits. ( 28644681 )
2017
14
Management of a neurotrophic deep corneal ulcer with amniotic membrane transplantation in a patient with functional monocular vision: A case report. ( 29390295 )
2017
15
Management of Infective Corneal Ulcer: Epidemiology Needs To Be Evaluated As Priority Basis. ( 27612884 )
2016
16
Corneal Ulcer Leading to Evisceration or Enucleation in a Tertiary Eye Care Center in Thailand: Clinical and Microbiological Characteristics. ( 27266225 )
2016
17
Bacterial corneal ulcer associated with common variable immune deficiency. ( 27491761 )
2016
18
Outcome of Urgent Penetrating Keratoplasty for Corneal Ulcer at Thammasat University Hospital. ( 27455827 )
2016
19
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )
2016
20
An unusual case of spontaneous Mycobacterium chelonae corneal ulcer in a healthy middle-aged adult. ( 27274315 )
2016
21
Diagnosis and Treatment of Pythium Insidiosum Corneal Ulcer in a Chinese Child: A Case Report and Literature Review. ( 28025573 )
2016
22
Orbital cellulitis and corneal ulcer due to Cedecea: First reported case and review of the literature. ( 27070554 )
2016
23
Microbiological profile of corneal ulcer cases diagnosed in a tertiary care ophthalmological institute in Nepal. ( 27899093 )
2016
24
Spontaneous Corneal Hydrops in a Patient with a Corneal Ulcer. ( 26889160 )
2016
25
Acacia honey accelerates in vitro corneal ulcer wound healing model. ( 27473120 )
2016
26
Rare case of bilateral perforated corneal ulcer due to gonococcal infection, managed with temporary periosteal graft. ( 26907819 )
2016
27
A Novel Tectonic Keratoplasty with Femtosecond Laser Intrastromal Lenticule for Corneal Ulcer and Perforation. ( 27453231 )
2016
28
Fungal keratitis in patients with corneal ulcer attending Minilik II Memorial Hospital, Addis Ababa, Ethiopia. ( 27576913 )
2016
29
Acquired anterior staphyloma after corneal ulcer associated with the use of crack. ( 27626156 )
2016
30
Bilateral sterile perforated corneal ulcer in an HIV case. ( 26265852 )
2015
31
Community practice patterns for bacterial corneal ulcer evaluation and treatment. ( 25536529 )
2015
32
Treatment of Acanthamoeba neurotrophic corneal ulcer with topical matrix therapy. ( 26101555 )
2015
33
Night market contact lens-related corneal ulcer: Should we increase public awareness? ( 26425295 )
2015
34
Corneal ulcer? Think beyond only a bacterial etiology. ( 25609872 )
2015
35
Epidemiological Aspect and common Bacterial and Fungal isolates from Suppurative Corneal Ulcer in Mymensingh Region. ( 26007250 )
2015
36
Pink hypopyon in a patient with Serratia marcescens corneal ulceration. ( 25861400 )
2015
37
Experimental study on cryotherapy for fungal corneal ulcer. ( 25880872 )
2015
38
Alpha-1-antitrypsin associated panniculitis and corneal ulcer with a rare allelic variant (PiFZ): a case report. ( 26474730 )
2015
39
Long-term efficacy of glycerine-processed amniotic membrane transplantation in patients with corneal ulcer. ( 25773445 )
2015
40
The corneal ulcer one-touch study: a simplified microbiological specimen collection method. ( 25244977 )
2014
41
Corneal ulcer caused by nocardia brasiliensis in a patient with diabetes. ( 24790888 )
2014
42
In Vitro Antibiotic Susceptibility of Pseudomonas aeruginosa Corneal Ulcer Isolates. ( 24564536 )
2014
43
Cunninghamella spinosum fungal corneal ulcer- first case report. ( 24722275 )
2014
44
Simultaneous study of matrix metalloproteinases, proinflammatory cytokines, and soluble cytokine receptors in the tears of noninfectious corneal ulcer patients. ( 25005620 )
2014
45
Complementary treatment of contact lens-induced corneal ulcer using honey: A case report. ( 25278429 )
2014
46
Repositioning of pedicle conjunctival flap performed for refractory corneal ulcer. ( 24669154 )
2014
47
Acinetobacter junii as an aetiological agent of corneal ulcer. ( 25056128 )
2014
48
Antibiotic susceptibility pattern of bacteria isolated from corneal ulcer in a tertiary level eye hospital. ( 26402978 )
2014
49
In vitro susceptibility of filamentous fungal isolates from a corneal ulcer clinical trial. ( 24439440 )
2014
50
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. ( 23448560 )
2013

Variations for Corneal Ulcer

Expression for Corneal Ulcer

Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for Corneal Ulcer

Pathways related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL11 CCR1 DHX9 IL1B MMP2 MMP3
2
Show member pathways
13.13 CCL11 CCR1 CCR3 IL1B NGF
3
Show member pathways
13.02 CCL11 CCR1 IL1B MMP2 MMP3 MMP9
4
Show member pathways
13.01 CCL11 CCR1 CCR3 IL1B NGF
5
Show member pathways
12 CCL11 IL1B MMP3 MMP9
6 11.86 IL1B MMP2 MMP9
7 11.78 MMP2 MMP3 MMP9
8
Show member pathways
11.75 CCL11 CCR1 CCR3
9
Show member pathways
11.74 CCL11 CCR1 CCR3 MMP2 MMP3 MMP9
10 11.7 IL1B MMP3 MMP9
11
Show member pathways
11.65 MMP2 MMP3 MMP9
12 11.58 MMP2 MMP3 MMP9
13 11.41 CCL11 IL1B MMP2 MMP3 MMP9
14 11.37 MMP2 MMP3 MMP9
15
Show member pathways
11.36 IL1B MMP2 MMP3 MMP9
16 11.31 CCR1 IL1B
17 11.3 MMP2 MMP9
18
Show member pathways
11.26 MMP2 MMP9
19 11.2 MMP3 MMP9
20 11.12 MMP2 MMP9
21 11.08 MMP2 MMP9
22 10.98 MMP2 MMP9
23 10.92 MMP2 MMP9
24 10.9 CCR3 IL1B MMP9
25 10.82 CCL11 CCR3 IL1B MMP2 MMP9

GO Terms for Corneal Ulcer

Cellular components related to Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 CCL11 IL1B MMP2 MMP3 MMP9 NGF

Biological processes related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.63 CCL11 CCR1 CCR3
2 positive regulation of angiogenesis GO:0045766 9.61 CCL11 CCR3 IL1B
3 extracellular matrix disassembly GO:0022617 9.54 MMP2 MMP3 MMP9
4 endodermal cell differentiation GO:0035987 9.52 MMP2 MMP9
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.51 MMP2 MMP9
6 chemokine-mediated signaling pathway GO:0070098 9.5 CCL11 CCR1 CCR3
7 positive regulation of interleukin-6 secretion GO:2000778 9.49 DHX9 IL1B
8 positive regulation of innate immune response GO:0045089 9.48 DHX9 MMP2
9 positive regulation of cell migration GO:0030335 9.46 CCL11 CCR1 IL1B MMP9
10 collagen catabolic process GO:0030574 9.43 MMP2 MMP3 MMP9
11 regulation of defense response to virus by host GO:0050691 9.4 DHX9 IL1B
12 embryo implantation GO:0007566 9.13 IL1B MMP2 MMP9
13 inflammatory response GO:0006954 9.02 CCL11 CCR1 CCR3 DHX9 IL1B

Molecular functions related to Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.54 MMP2 MMP3 MMP9
2 metallopeptidase activity GO:0008237 9.43 MMP2 MMP3 MMP9
3 chemokine receptor activity GO:0004950 9.32 CCR1 CCR3
4 C-C chemokine receptor activity GO:0016493 9.16 CCR1 CCR3
5 metalloendopeptidase activity GO:0004222 9.13 MMP2 MMP3 MMP9
6 C-C chemokine binding GO:0019957 8.62 CCR1 CCR3

Sources for Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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