MCID: CRN028
MIFTS: 55

Corneal Ulcer malady

Eye diseases category
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Summaries for Corneal Ulcer

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Wikipedia:65 Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the... more...

MalaCards based summary: Corneal Ulcer is related to keratoconjunctivitis and keratitis. An important gene associated with Corneal Ulcer is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and A-beta Uptake and Degradation. The drugs sulfacetamide and sulfisoxazole diolamine and the compounds ilomastat and hcec have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and liver, and related mouse phenotypes are tumorigenesis and skeleton.

Aliases & Classifications for Corneal Ulcer

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Corneal Ulcer, Aliases & Descriptions:

Name: Corneal Ulcer 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:8463
NCIt39 C50515
ICD9CM27 370.0, 370.00
MeSH34 D003320
ICD1025 H16.0

Related Diseases for Corneal Ulcer

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Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis31.5CCL11
2keratitis30.7MMP9, TAT, MMP2
3vernal keratoconjunctivitis30.3NGF, CCL11, MMP9
4keratoconus30.1MMP2, MMP3
5pneumonia29.9IL10, IL1B, CCL11
6diabetes mellitus29.6MMP9, MMP3, IL1B, NGF
7mycotic corneal ulcer10.5
8eosinophilic gastroenteritis10.5CCL11
9perforated corneal ulcer10.5
10endophthalmitis10.4
11rhinitis10.4PRG2, CCL11
12conjunctivitis10.4
13hypereosinophilic syndrome10.4PRG2, CCL11
14cataract10.4
15marginal corneal ulcer10.4
16hypopyon10.4
17sinusitis10.3CCL11, PRG2
18dermatitis herpetiformis10.3CCL11, MMP3
19degenerative disc disease10.3IL1B
20central corneal ulcer10.3
21ring corneal ulcer10.3
22herpes simplex10.3
23atopic keratoconjunctivitis10.3
24bronchitis10.3CCL11, CCR3
25poems syndrome10.3IL1B
26blau syndrome10.3IL1B
27factor vii deficiency10.3MUC5AC, NGF
28malaria10.3IL10, TAT
29pulmonary eosinophilia10.3PRG2, CCR3, CCL11
30esophagitis10.3CCR3, CCL11, PRG2
31keratoconjunctivitis sicca10.3
32influenza10.3
33haemophilus influenzae10.3
34mycobacterium fortuitum10.3
35respiratory failure10.2CCL11, CCR3, MUC5AC
36bullous pemphigoid10.2PRG2, CCL11
37periodontal disease10.2MMP2, MMP3
38kawasaki disease10.2MMP9, MMP3
39atopic dermatitis10.2NGF, CCL11, CCR3
40demyelinating disease10.2NGF, IL10
41relapsing-remitting multiple sclerosis10.2IL10, MMP9
42cholesteatoma10.2MMP3, MMP9
43burns10.2
44graft versus host disease10.2
45keratopathy10.2
46exophthalmos10.2
47cicatricial pemphigoid10.2
48keratomalacia10.2
49ectropion10.2
50entropion10.2

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to corneal ulcer

Symptoms for Corneal Ulcer

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Drugs & Therapeutics for Corneal Ulcer

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Drug clinical trials:

Search ClinicalTrials for Corneal Ulcer

Search NIH Clinical Center for Corneal Ulcer

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Corneal Ulcer

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Anatomical Context for Corneal Ulcer

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MalaCards organs/tissues related to Corneal Ulcer:

32
Eye, Bone, Liver, Testes

Animal Models for Corneal Ulcer or affiliated genes

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MGI Mouse Phenotypes related to Corneal Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IL1B, IL10, MMP2, MMP9
2MP:00053908.0MMP9, MMP2, MMP3, IL10, IL1B
3MP:00053887.6MMP9, MMP2, PRG2, CCR3, CCL11, IL10
4MP:00036317.5NGF, MMP9, MMP2, MMP3, IL10, IL1B
5MP:00053767.0NGF, MUC5AC, MMP9, MMP2, MMP3, CCR3
6MP:00053976.8MMP9, MMP2, MMP3, PRG2, CCR3, CCL11
7MP:00053876.3IL1B, MUC5AC, MMP9, MMP2, MMP3, PRG2

Publications for Corneal Ulcer

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Articles related to Corneal Ulcer:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
The corneal ulcer one-touch study: a simplified microbiological specimen collection method. (25244977)
2014
2
Repositioning of pedicle conjunctival flap performed for refractory corneal ulcer. (24669154)
2014
3
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
4
Cost evaluation of corneal ulcer treatment. (23691700)
2013
5
Evaluation of risk factors for development of corneal ulcer after nonocular surgery in dogs: 14 cases (2009-2011). (23683020)
2013
6
Etiological agents of corneal ulcer: five years prospective study in eastern Nepal. (24047020)
2012
7
Bilateral corneal ulceration in keratoconus. (23034295)
2012
8
Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea. (22531699)
2012
9
Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). (21987582)
2012
10
Role of voriconazole in combined acanthamoeba and fungal corneal ulcer. (21733740)
2011
11
Late-onset Klebsiella oxytoca flap-margin-related corneal ulcer following laser in situ keratomileusis. (21782101)
2011
12
Efficacy and safety of bromfenac for the treatment of corneal ulcer pain. (20845001)
2010
13
Corneal ulceration due to vitamin A deficiency in Zellweger syndrome. (19541270)
2009
14
Use of grid keratotomy for the treatment of indolent corneal ulcer in a llama. (17494370)
2007
15
Isolation, vancomycin resistance and biofilm production of Staphylococcus epidermidis from patients with conjunctivitis, corneal ulcers, and endophthalmitis. (18293657)
2006
16
Fungal keratitis in patients with corneal ulcer in Sari, Northern Iran. (16859055)
2006
17
Corneal ulcer in a young child with autosomal recessive epidermolysis bullosa. (17162976)
2006
18
Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses. (16178841)
2005
19
Aeromonas sobria corneal ulcer. (12579184)
2003
20
Active form of gelatinases in tear fluidin patients with corneal ulcer or ocular burn. (12967855)
2003
21
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
22
Serratia Marcescens corneal ulcer as a complication of orthokeratology. (11476690)
2001
23
Multilayer vs. monolayer amniotic membrane transplantation for deep corneal ulcer treatment. (11817009)
2001
24
Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis--a case report of corneal ulcer. (9348738)
1997
25
Corneal ulcer associated with contamination of aerosol saline spray tip. (9439366)
1997
26
Therapy-resistant corneal ulcer in a six-year old patient. (9009360)
1996
27
Corneal ulcer in a child caused by Nocardia asteroides following corneal perforation. (7752036)
1995
28
History and clinical signs. Bilateral exophthalmos, and left lagophthalmos and corneal ulceration. (7648545)
1995
29
Corneal ulceration in a patient with alpha 1 antitrypsin deficiency. (7918295)
1994
30
CMDBS, functional analogue of heparin sulfate as a new class of corneal ulcer healing agents. (7536320)
1994
31
Human infectious corneal ulcer caused by Pythium insidiosum. (8458239)
1993
32
Isolation of Kingella kingae from a corneal ulcer. (1401031)
1992
33
Pseudomonas corneal ulcer associated with rigid, gas-permeable, daily-wear lenses in a patient infected with human immunodeficiency virus. (1543232)
1992
34
Acinetobacter corneal ulcer after penetrating keratoplasty. (2658621)
1989
35
Topical antibiotics in the management of corneal ulcer. (3069735)
1988
36
Pseudomonas aeruginosa corneal ulcer associated with an aerosol can of preservative-free saline. Case report. (3142448)
1988
37
Spontaneous fungal corneal ulcer as an ocular manifestation of AIDS. (3631189)
1987
38
A new rapid immunoperoxidase diagnostic staining of herpes simplex virus 1 indolent corneal ulcer. (6100242)
1984
39
Pseudomonas corneal ulcer treated by full-thickness graft in a lamellar bed. (7018342)
1981
40
Lysozyme in corneal ulcer. (1200558)
1975
41
Colistin and genticyn in the treatment of Pseudomonas corneal ulcer. (4429309)
1974
42
Hypopyon corneal ulcers in rural Bengal. (4401770)
1972
43
Corneal ulcer due to Pseudomonas aeruginosa. A comparison of the disease in California and El Salvador. (4995262)
1971
44
Intractable Mycobacterium fortuitum corneal ulcer in man. (5547533)
1971
45
Corneal ulcer and its management. (5446075)
1970
46
Corneal ulcer. (13110464)
1953
47
B. pyocyaneus corneal ulcer treated with penicillin. (18872482)
1948
48
A case of corneal ulcer treated with penicillin solution. (20285503)
1947
49
Corneal ulcer. (20997126)
1946
50
Treatment of corneal ulcer. (20273942)
1946

Variations for Corneal Ulcer

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Expression for genes affiliated with Corneal Ulcer

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Expression patterns in normal tissues for genes affiliated with Corneal Ulcer

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Pathways for genes affiliated with Corneal Ulcer

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Pathways related to Corneal Ulcer according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP9, MMP3
29.6MMP9, MMP2
39.6MMP9, MMP2
49.6MMP9, MMP2
59.6MMP2, MMP9
69.6MMP2, MMP9
79.6MMP9, MMP2
89.3IL10, IL1B
99.3IL10, IL1B
109.3IL10, IL1B
119.3IL10, IL1B
129.3IL1B, IL10
13
Show member pathways
9.3MMP3, MMP2, MMP9
14
Show member pathways
9.3MMP9, MMP2, MMP3
15
Show member pathways
9.3MMP3, MMP2, MMP9
169.2IL1B, MMP3, MMP9
179.0IL1B, IL10, NGF
18
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.9IL1B, IL10, MMP9
19
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.9MMP2, IL10, IL1B
20
Show member pathways
8.8NGF, MMP9, MMP3, CCR3, CCL11
21
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.8NGF, MMP9, MMP2, IL1B
22
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
23
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
24
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
25
Show member pathways
8.2PRG2, CCL11, IL10, IL1B
26
Show member pathways
7.9PRG2, CCR3, CCL11, IL10, IL1B
27
Show member pathways
7.8CCL11, CCR3, PRG2, MMP3, MMP2, MMP9

Compounds for genes affiliated with Corneal Ulcer

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Compounds related to Corneal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1ilomastat449.6MMP3, MMP2, MMP9
2hcec449.6NGF, MMP2, MMP3
3latanoprost44 1110.6MMP3, MMP2, MMP9
4(4-aminophenyl)mercuric acetate449.5MMP3, MMP2, MMP9
5gm 6001619.4MMP9, MMP2, MMP3
6uk 383367619.4MMP9, MMP3, MMP2
7gi 254023x619.3MMP3, MMP2, MMP9
8doxycycline44 1110.2TAT, MMP3, MMP9, MMP2
9pdtc449.1NGF, MMP9, IL1B, MMP2
10celecoxib44 61 28 50 24 1114.0IL1B, MMP3, MMP2, MMP9
11butyrate449.0MMP9, CCR3, MMP3, TAT, CCL11
12matrigel449.0NGF, MMP9, MMP2, CCL11, MMP3
13hydroxamate449.0MMP2, MMP3, MMP9
14ibuprofen44 28 50 24 1112.9IL1B, IL10, MMP3, MMP2
15pentoxifylline44 119.9MMP2, IL1B, TAT, IL10
16troglitazone44 28 61 1111.9IL1B, MMP2, MMP3, MMP9, CCL11
17hyaluronic acid44 249.8MMP3, IL1B, CCL11, MMP9, MMP2
18ivig448.8IL10, MMP2, MMP9, IL1B
19prostaglandin448.8IL1B, MUC5AC, MMP9, MMP3, CCL11
20hematoxylin448.7MUC5AC, MMP3, PRG2, MMP9
21hydrocortisone44 2 61 1111.7TAT, IL1B, IL10, MMP2
22herbimycin a44 619.6NGF, CCR3, MMP2, IL1B, CCL11, MMP9
23prednisolone44 28 1110.5MMP3, MMP2, TAT, IL10, CCL11, NGF
24ribonucleic acid448.5MUC5AC, MMP9, MMP3, IL1B, MMP2
25cyclosporin a44 28 6110.5MMP9, MMP3, CCL11, TAT, IL10, NGF
26tgf beta1448.5MMP3, IL1B, IL10, MMP2, MMP9
27thymidine44 249.4NGF, CCR3, IL10, IL1B, CCL11
28ccl344 289.4MMP9, IL1B, CCR3, CCL11, TAT, IL10
29alanine448.4NGF, MMP9, MMP2, MMP3, CCR3, CCL11
30n acetylcysteine448.3IL1B, CCL11, MMP3, MMP2, MMP9, MUC5AC
31paraffin448.3MUC5AC, MMP9, IL10, MMP3, MMP2
32pd 98,059448.3NGF, MMP2, MMP9, MMP3, IL1B, MUC5AC
33ly294002448.3IL10, CCL11, IL1B, MMP2, MMP9, NGF
34indomethacin44 28 61 1111.2IL1B, TAT, PRG2, MMP3, NGF, CCL11
35rantes448.0CCR3, CCL11, IL10, IL1B, MMP3, MMP9
36actinomycin d447.9CCL11, TAT, IL1B, NGF, MMP9, PRG2
37cycloheximide447.9NGF, MMP2, MMP3, TAT, MMP9, IL1B
38oxygen44 248.8MUC5AC, MMP3, TAT, CCL11, CCR3, PRG2
39pge2447.7IL1B, IL10, CCL11, MMP3, MMP2, MMP9
40methotrexate50 44 119.7IL1B, MUC5AC, MMP9, MMP3, IL10, MMP2
41vegf447.6TAT, IL10, CCL11, IL1B, MMP2, NGF
42sb 20358044 618.5MMP9, CCL11, MMP2, MMP3, MUC5AC, NGF
43estrogen447.4TAT, MMP9, MMP2, MMP3, PRG2, MUC5AC
44cysteine447.3MMP2, MMP9, PRG2, MMP3, MUC5AC, NGF
45calcium44 50 24 1110.3MMP9, MUC5AC, MMP2, MMP3, PRG2, CCR3
46dexamethasone44 50 28 1110.2NGF, MMP3, TAT, IL1B, CCL11, MUC5AC
47genistein44 28 61 2 24 1112.1CCL11, CCR3, MMP2, MMP3, MMP9, PRG2
48tyrosine447.1NGF, MMP3, MUC5AC, MMP9, MMP2, TAT
49histamine44 28 248.8MMP3, CCR3, CCL11, PRG2, MUC5AC, IL10
50retinoic acid44 247.6TAT, IL1B, CCL11, CCR3, PRG2, MMP3

GO Terms for genes affiliated with Corneal Ulcer

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Cellular components related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.3MMP3, MMP2, MMP9
2extracellular spaceGO:0056157.4IL1B, NGF, MMP9, MMP2, MMP3, CCL11
3extracellular regionGO:0055767.0NGF, MMP9, MMP2, MMP3, PRG2, CCL11

Biological processes related to Corneal Ulcer according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:00931410.0CCL11, NGF
2extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7NGF, IL1B
3cellular response to amino acid stimulusGO:0712309.6MMP3, MMP2
4positive regulation of angiogenesisGO:0457669.6IL1B, CCL11, CCR3
5collagen catabolic processGO:0305749.5MMP3, MMP2, MMP9
6response to glucocorticoidGO:0513849.4NGF, IL10, TAT
7extracellular matrix disassemblyGO:0226179.4MMP3, MMP2, MMP9
8proteolysisGO:0065089.4MMP9, MMP2, MMP3
9embryo implantationGO:0075669.3IL1B, MMP2, MMP9
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2NGF, IL10, IL1B
11extracellular matrix organizationGO:0301989.0MMP3, MMP2, MMP9
12immune responseGO:0069558.8IL1B, CCL11, PRG2
13inflammatory responseGO:0069548.7IL1B, IL10, CCL11, CCR3, NGF

Molecular functions related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.3MMP3, MMP2, MMP9

Products for genes affiliated with Corneal Ulcer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Corneal Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet