MCID: CRN028
MIFTS: 55

Corneal Ulcer malady

Eye diseases category

Summaries for Corneal Ulcer

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66Wikipedia, 34MalaCards
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Wikipedia:66 Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the... more...

MalaCards: Corneal Ulcer is related to keratoconjunctivitis and keratitis. An important gene associated with Corneal Ulcer is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and A-beta Uptake and Degradation. The drugs sulfacetamide and sulfisoxazole diolamine and the compounds ilomastat and hcec have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and liver, and related mouse phenotypes are tumorigenesis and skeleton.

Aliases & Classifications for Corneal Ulcer

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9Disease Ontology, 46Novoseek, 63UMLS, 41NCIt, 36MeSH, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal ulcer 9 46 63


External Ids:

Disease Ontology9 DOID:8463
NCIt41 C50515
MeSH36 D003320
ICD9CM28 370.00, 370.0
ICD1026 H16.0

Related Diseases for Corneal Ulcer

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18GeneCards, 19GeneDecks
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Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis30.9CCL11
2keratitis30.7MMP9, TAT, MMP2
3vernal keratoconjunctivitis30.1NGF, CCL11, MMP9
4keratoconus30.0MMP2, MMP3
5pneumonia30.0IL10, IL1B, CCL11
6diabetes mellitus29.9MMP9, MMP3, IL1B, NGF
7mycotic corneal ulcer10.5
8perforated corneal ulcer10.5
9endophthalmitis10.4
10conjunctivitis10.4
11marginal corneal ulcer10.3
12cataract10.3
13hypopyon10.3
14central corneal ulcer10.3
15ring corneal ulcer10.3
16herpes simplex10.3
17atopic keratoconjunctivitis10.3
18keratoconjunctivitis sicca10.2
19influenza10.2
20mycobacterium fortuitum10.2
21graft versus host disease10.2
22burns10.2
23exophthalmos10.2
24cicatricial pemphigoid10.2
25keratomalacia10.2
26ectropion10.2
27entropion10.2
28keratopathy10.2
29myopia10.2
30uveitis10.2
31lymphedema-distichiasis syndrome10.2
32anterior uveitis10.2
33klebsiella10.2
34epidermolysis bullosa dystrophica, ar10.2
35tarsal kink syndrome10.2
36eosinophilic gastroenteritis10.1CCL11
37rhinitis10.1PRG2, CCL11
38hypereosinophilic syndrome10.1PRG2, CCL11
39sinusitis10.1CCL11, PRG2
40dermatitis herpetiformis10.1CCL11, MMP3
41degenerative disc disease10.1IL1B
42bronchitis10.1CCL11, CCR3
43poems syndrome10.1IL1B
44blau syndrome10.1IL1B
45factor vii deficiency10.1MUC5AC, NGF
46malaria10.1IL10, TAT
47pulmonary eosinophilia10.1PRG2, CCR3, CCL11
48esophagitis10.1CCR3, CCL11, PRG2
49respiratory failure10.1CCL11, CCR3, MUC5AC
50bullous pemphigoid10.1PRG2, CCL11

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to corneal ulcer

Symptoms for Corneal Ulcer

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Drugs & Therapeutics for Corneal Ulcer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Corneal Ulcer

Drug clinical trials:

Search ClinicalTrials for Corneal Ulcer

Search NIH Clinical Center for Corneal Ulcer

Search CenterWatch for Corneal Ulcer

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Corneal Ulcer

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Anatomical Context for Corneal Ulcer

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34MalaCards
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MalaCards organs/tissues related to Corneal Ulcer:

34
Eye, Bone, Liver, Testes

Animal Models for Corneal Ulcer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Corneal Ulcer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IL1B, IL10, MMP2, MMP9
2MP:00053908.0MMP9, MMP2, MMP3, IL10, IL1B
3MP:00053887.6MMP9, MMP2, PRG2, CCR3, CCL11, IL10
4MP:00036317.5NGF, MMP9, MMP2, MMP3, IL10, IL1B
5MP:00053767.0NGF, MUC5AC, MMP9, MMP2, MMP3, CCR3
6MP:00053976.8MMP9, MMP2, MMP3, PRG2, CCR3, CCL11
7MP:00053876.3IL1B, MUC5AC, MMP9, MMP2, MMP3, PRG2

Publications for Corneal Ulcer

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Sources:
53PubMed
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Articles related to Corneal Ulcer:

(show top 50)    (show all 309)
idTitleAuthorsYear
1
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. (23448560)
2013
2
Cost evaluation of corneal ulcer treatment. (23691700)
2013
3
Evaluation of risk factors for development of corneal ulcer after nonocular surgery in dogs: 14 cases (2009-2011). (23683020)
2013
4
Etiological agents of corneal ulcer: five years prospective study in eastern Nepal. (24047020)
2012
5
Bilateral corneal ulceration in keratoconus. (23034295)
2012
6
Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea. (22531699)
2012
7
Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). (21987582)
2012
8
Role of voriconazole in combined acanthamoeba and fungal corneal ulcer. (21733740)
2011
9
Late-onset Klebsiella oxytoca flap-margin-related corneal ulcer following laser in situ keratomileusis. (21782101)
2011
10
Efficacy and safety of bromfenac for the treatment of corneal ulcer pain. (20845001)
2010
11
Corneal ulceration due to vitamin A deficiency in Zellweger syndrome. (19541270)
2009
12
Streptococcus bovis causing perforating corneal ulcer. (19092424)
2009
13
Use of grid keratotomy for the treatment of indolent corneal ulcer in a llama. (17494370)
2007
14
Isolation, vancomycin resistance and biofilm production of Staphylococcus epidermidis from patients with conjunctivitis, corneal ulcers, and endophthalmitis. (18293657)
2006
15
Fungal keratitis in patients with corneal ulcer in Sari, Northern Iran. (16859055)
2006
16
Corneal ulcer in a young child with autosomal recessive epidermolysis bullosa. (17162976)
2006
17
Equine amniotic membrane transplantation for corneal ulceration and keratomalacia in three horses. (16178841)
2005
18
Aeromonas sobria corneal ulcer. (12579184)
2003
19
Active form of gelatinases in tear fluidin patients with corneal ulcer or ocular burn. (12967855)
2003
20
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
21
Serratia Marcescens corneal ulcer as a complication of orthokeratology. (11476690)
2001
22
Multilayer vs. monolayer amniotic membrane transplantation for deep corneal ulcer treatment. (11817009)
2001
23
Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis--a case report of corneal ulcer. (9348738)
1997
24
Nigrospora causing corneal ulcer--a case report. (9444870)
1997
25
Therapy-resistant corneal ulcer in a six-year old patient. (9009360)
1996
26
Corneal ulcer in a child caused by Nocardia asteroides following corneal perforation. (7752036)
1995
27
History and clinical signs. Bilateral exophthalmos, and left lagophthalmos and corneal ulceration. (7648545)
1995
28
Corneal ulceration in a patient with alpha 1 antitrypsin deficiency. (7918295)
1994
29
CMDBS, functional analogue of heparin sulfate as a new class of corneal ulcer healing agents. (7536320)
1994
30
Human infectious corneal ulcer caused by Pythium insidiosum. (8458239)
1993
31
Isolation of Kingella kingae from a corneal ulcer. (1401031)
1992
32
Pseudomonas corneal ulcer associated with rigid, gas-permeable, daily-wear lenses in a patient infected with human immunodeficiency virus. (1543232)
1992
33
Acinetobacter corneal ulcer after penetrating keratoplasty. (2658621)
1989
34
Topical antibiotics in the management of corneal ulcer. (3069735)
1988
35
Pseudomonas aeruginosa corneal ulcer associated with an aerosol can of preservative-free saline. Case report. (3142448)
1988
36
Spontaneous fungal corneal ulcer as an ocular manifestation of AIDS. (3631189)
1987
37
A new rapid immunoperoxidase diagnostic staining of herpes simplex virus 1 indolent corneal ulcer. (6100242)
1984
38
Herpetic corneal ulcer following radial keratotomy. (6402972)
1983
39
Pseudomonas corneal ulcer treated by full-thickness graft in a lamellar bed. (7018342)
1981
40
Lysozyme in corneal ulcer. (1200558)
1975
41
Colistin and genticyn in the treatment of Pseudomonas corneal ulcer. (4429309)
1974
42
Hypopyon corneal ulcers in rural Bengal. (4401770)
1972
43
Corneal ulcer due to Pseudomonas aeruginosa. A comparison of the disease in California and El Salvador. (4995262)
1971
44
Intractable Mycobacterium fortuitum corneal ulcer in man. (5547533)
1971
45
Corneal ulcer and its management. (5446075)
1970
46
Corneal ulcer. (13110464)
1953
47
B. pyocyaneus corneal ulcer treated with penicillin. (18872482)
1948
48
A case of corneal ulcer treated with penicillin solution. (20285503)
1947
49
Corneal ulcer. (20997126)
1946
50
Treatment of corneal ulcer. (20273942)
1946

Variations for Corneal Ulcer

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Expression for genes affiliated with Corneal Ulcer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Ulcer

Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for genes affiliated with Corneal Ulcer

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Sources:
51PathCards, 61Thomson Reuters, 55R&D Systems, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 56Reactome, 13EMD Millipore
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Pathways related to Corneal Ulcer according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP9, MMP3
29.6MMP9, MMP2
39.6MMP9, MMP2
49.6MMP9, MMP2
59.6MMP2, MMP9
69.6MMP2, MMP9
79.6MMP9, MMP2
89.3IL10, IL1B
99.3IL10, IL1B
109.3IL10, IL1B
119.3IL10, IL1B
129.3IL1B, IL10
13
Show member pathways
9.3MMP3, MMP2, MMP9
14
Show member pathways
9.3MMP9, MMP2, MMP3
15
Show member pathways
9.3MMP3, MMP2, MMP9
169.2IL1B, MMP3, MMP9
179.0IL1B, IL10, NGF
18
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.9IL1B, IL10, MMP9
19
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.9MMP2, IL10, IL1B
20
Show member pathways
8.8NGF, MMP9, MMP3, CCR3, CCL11
21
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.8NGF, MMP9, MMP2, IL1B
22
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
23
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
24
Show member pathways
8.7CCR3, CCL11, IL10, IL1B
25
Show member pathways
8.2PRG2, CCL11, IL10, IL1B
26
Show member pathways
7.9PRG2, CCR3, CCL11, IL10, IL1B
27
Show member pathways
7.8CCL11, CCR3, PRG2, MMP3, MMP2, MMP9

Compounds for genes affiliated with Corneal Ulcer

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Corneal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1ilomastat469.6MMP3, MMP2, MMP9
2hcec469.6NGF, MMP2, MMP3
3latanoprost46 1210.6MMP3, MMP2, MMP9
4(4-aminophenyl)mercuric acetate469.5MMP3, MMP2, MMP9
5gm 6001629.4MMP9, MMP2, MMP3
6uk 383367629.4MMP9, MMP3, MMP2
7gi 254023x629.3MMP3, MMP2, MMP9
8doxycycline46 1210.2TAT, MMP3, MMP9, MMP2
9pdtc469.1NGF, MMP9, IL1B, MMP2
10celecoxib46 62 30 52 25 1214.0IL1B, MMP3, MMP2, MMP9
11butyrate469.0MMP9, CCR3, MMP3, TAT, CCL11
12matrigel469.0NGF, MMP9, MMP2, CCL11, MMP3
13hydroxamate469.0MMP2, MMP3, MMP9
14ibuprofen46 30 52 25 1212.9IL1B, IL10, MMP3, MMP2
15pentoxifylline46 129.9MMP2, IL1B, TAT, IL10
16troglitazone46 30 62 1211.9IL1B, MMP2, MMP3, MMP9, CCL11
17hyaluronic acid46 259.8MMP3, IL1B, CCL11, MMP9, MMP2
18ivig468.8IL10, MMP2, MMP9, IL1B
19prostaglandin468.8IL1B, MUC5AC, MMP9, MMP3, CCL11
20hematoxylin468.7MUC5AC, MMP3, PRG2, MMP9
21hydrocortisone46 3 62 1211.7TAT, IL1B, IL10, MMP2
22herbimycin a46 629.6NGF, CCR3, MMP2, IL1B, CCL11, MMP9
23prednisolone46 30 1210.5MMP3, MMP2, TAT, IL10, CCL11, NGF
24ribonucleic acid468.5MUC5AC, MMP9, MMP3, IL1B, MMP2
25cyclosporin a46 30 6210.5MMP9, MMP3, CCL11, TAT, IL10, NGF
26tgf beta1468.5MMP3, IL1B, IL10, MMP2, MMP9
27thymidine46 259.4NGF, CCR3, IL10, IL1B, CCL11
28ccl346 309.4MMP9, IL1B, CCR3, CCL11, TAT, IL10
29alanine468.4NGF, MMP9, MMP2, MMP3, CCR3, CCL11
30n acetylcysteine468.3IL1B, CCL11, MMP3, MMP2, MMP9, MUC5AC
31paraffin468.3MUC5AC, MMP9, IL10, MMP3, MMP2
32pd 98,059468.3NGF, MMP2, MMP9, MMP3, IL1B, MUC5AC
33ly294002468.3IL10, CCL11, IL1B, MMP2, MMP9, NGF
34indomethacin46 30 62 1211.2IL1B, TAT, PRG2, MMP3, NGF, CCL11
35rantes468.0CCR3, CCL11, IL10, IL1B, MMP3, MMP9
36actinomycin d467.9CCL11, TAT, IL1B, NGF, MMP9, PRG2
37cycloheximide467.9NGF, MMP2, MMP3, TAT, MMP9, IL1B
38oxygen46 258.8MUC5AC, MMP3, TAT, CCL11, CCR3, PRG2
39pge2467.7IL1B, IL10, CCL11, MMP3, MMP2, MMP9
40methotrexate52 46 129.7IL1B, MUC5AC, MMP9, MMP3, IL10, MMP2
41vegf467.6TAT, IL10, CCL11, IL1B, MMP2, NGF
42sb 20358046 628.5MMP9, CCL11, MMP2, MMP3, MUC5AC, NGF
43estrogen467.4TAT, MMP9, MMP2, MMP3, PRG2, MUC5AC
44cysteine467.3MMP2, MMP9, PRG2, MMP3, MUC5AC, NGF
45calcium46 52 25 1210.3MMP9, MUC5AC, MMP2, MMP3, PRG2, CCR3
46dexamethasone46 52 30 1210.2NGF, MMP3, TAT, IL1B, CCL11, MUC5AC
47genistein46 30 62 3 25 1212.1CCL11, CCR3, MMP2, MMP3, MMP9, PRG2
48tyrosine467.1NGF, MMP3, MUC5AC, MMP9, MMP2, TAT
49histamine46 30 258.8MMP3, CCR3, CCL11, PRG2, MUC5AC, IL10
50retinoic acid46 257.6TAT, IL1B, CCL11, CCR3, PRG2, MMP3

GO Terms for genes affiliated with Corneal Ulcer

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Sources:
17Gene Ontology
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Cellular components related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.3MMP3, MMP2, MMP9
2extracellular spaceGO:0056157.4IL1B, NGF, MMP9, MMP2, MMP3, CCL11
3extracellular regionGO:0055767.0NGF, MMP9, MMP2, MMP3, PRG2, CCL11

Biological processes related to Corneal Ulcer according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to radiationGO:00931410.0CCL11, NGF
2extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7NGF, IL1B
3cellular response to amino acid stimulusGO:0712309.6MMP3, MMP2
4positive regulation of angiogenesisGO:0457669.6IL1B, CCL11, CCR3
5collagen catabolic processGO:0305749.5MMP3, MMP2, MMP9
6response to glucocorticoidGO:0513849.4NGF, IL10, TAT
7extracellular matrix disassemblyGO:0226179.4MMP3, MMP2, MMP9
8proteolysisGO:0065089.4MMP9, MMP2, MMP3
9embryo implantationGO:0075669.3IL1B, MMP2, MMP9
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.2NGF, IL10, IL1B
11extracellular matrix organizationGO:0301989.0MMP3, MMP2, MMP9
12immune responseGO:0069558.8IL1B, CCL11, PRG2
13inflammatory responseGO:0069548.7IL1B, IL10, CCL11, CCR3, NGF

Molecular functions related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.3MMP3, MMP2, MMP9

Products for genes affiliated with Corneal Ulcer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corneal Ulcer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet