MCID: CRN028
MIFTS: 52

Corneal Ulcer malady

Eye diseases category

Summaries for Corneal Ulcer

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63Wikipedia, 32MalaCards
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Wikipedia:63 Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the... more...

MalaCards: Corneal Ulcer is related to keratoconjunctivitis and keratitis. An important gene associated with Corneal Ulcer is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Degradation of collagen and A-beta Plaque Formation & APP Metabolism . The drugs sulfacetamide and sulfisoxazole diolamine and the compounds cycloheximide and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and liver, and related mouse phenotypes are homeostasis/metabolism and respiratory system.

Aliases & Classifications for Corneal Ulcer

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal ulcer 8 44 60


External Ids:

Disease Ontology8 DOID:8463
ICD9CM27 370.00, 370.0
MeSH34 D003320
NCIt39 C50515
ICD1025 H16.0

Related Diseases for Corneal Ulcer

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to corneal ulcer

Clinical Features for Corneal Ulcer

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Drugs & Therapeutics for Corneal Ulcer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Corneal Ulcer

Drug clinical trials:

Search ClinicalTrials for Corneal Ulcer

Search NIH Clinical Center for Corneal Ulcer

Search CenterWatch for Corneal Ulcer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Corneal Ulcer

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Anatomical Context for Corneal Ulcer

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32MalaCards
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MalaCards organs/tissues related to Corneal Ulcer:

32
Eye, Bone, Liver, Skin, Testes, Endothelial

Animal Models for Corneal Ulcer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Corneal Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.1MUC5AC, NGF, CCR3
2MP:00053888.5CCL11, PRG2, MMP2, MMP9
3MP:00053876.3MMP9, CCL11, CCR3, PRG2, MUC5AC, IL10

Publications for Corneal Ulcer

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50PubMed
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Articles related to Corneal Ulcer:

(show top 50)    (show all 332)
idTitleAuthorsYear
1
Peripheral ulcerative keratitis and corneal melt: a 10-year single center review with historical comparison. (24240486)
2014
2
Cost evaluation of corneal ulcer treatment. (23691700)
2013
3
An environmental Sporothrix as a cause of corneal ulcer. (24432225)
2013
4
Abiotrophia defectiva causing infectious crystalline keratopathy and corneal ulcer after penetrating keratoplasty: a case report. (23514629)
2013
5
Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea. (22531699)
2012
6
Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). (21987582)
2012
7
Organism, minimum inhibitory concentration, and outcome in a fungal corneal ulcer clinical trial. (22333662)
2012
8
Role of voriconazole in combined acanthamoeba and fungal corneal ulcer. (21733740)
2011
9
Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial. (21283156)
2011
10
Presumed sterile corneal ulcer following autologous limbal stem cell and amniotic membrane transplantation: report of an unusual complication. (21599748)
2011
11
Prospective comparison of microbial culture and polymerase chain reaction in the diagnosis of corneal ulcer. (18707670)
2008
12
Corneal ulcer in a young child with autosomal recessive epidermolysis bullosa. (17162976)
2006
13
Incidence of corneal ulcer in hydrogel contact lens wearers and post-cataract endophthalmitis. Do they Compare? (16303528)
2004
14
Active form of gelatinases in tear fluidin patients with corneal ulcer or ocular burn. (12967855)
2003
15
Investigation of an anaerobic microbial community associated with a corneal ulcer by denaturing gradient gel electrophoresis and 16S rDNA sequence analysis. (12106952)
2002
16
Enzymatic mechanisms in corneal ulceration with specific reference to familial dysautonomia: potential for genetic approaches. (12613971)
2002
17
Atypical Herpes simplex keratitis (HSK) presenting as a perforated corneal ulcer with a large infiltrate in a contact lens wearer: multinucleated giant cells in the Giemsa smear offered a clue to the diagnosis. (11325340)
2001
18
Amniotic membrane transplantation in infectious corneal ulcer. (11588424)
2001
19
Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study. (15887725)
2001
20
Corneal ulcer: diagnosis and management. (17491983)
1999
21
Comparative studies on topical lomefloxacin and ciprofloxacin on ocular kinetic and experimental corneal ulcer. (10609773)
1999
22
Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis--a case report of corneal ulcer. (9348738)
1997
23
Congenital entropion and congenital corneal ulcer. (8597283)
1996
24
CMDBS, functional analogue of heparin sulfate as a new class of corneal ulcer healing agents. (7536320)
1994
25
Pseudomonas corneal ulcer associated with rigid, gas-permeable, daily-wear lenses in a patient infected with human immunodeficiency virus. (1543232)
1992
26
Infectious corneal ulcer with overextended wearing of disposable contact lenses. (2604765)
1989
27
Clinical and experimental mycotic corneal ulcer caused by Aspergillus fumigatus and the effect of oral ketoconazole in the treatment. (2682246)
1989
28
Pseudomonas corneal ulcer associated with colored cosmetic contact lenses in an emmetropic individual. (3341438)
1988
29
Inferior corneal ulcers associated with palpebral vernal conjunctivitis. (3134817)
1988
30
Corneal ulcer due to Listeria monocytogenes. (3608514)
1987
31
Mycobacterium avium-intracellulare corneal ulcer. (3677722)
1987
32
A comparative study of anti-fungal drugs in mycotic corneal ulcer. (3508765)
1987
33
Sulfonamide-associated keratoconjunctivitis sicca and corneal ulceration in a dysuric dog. (3490464)
1986
34
Corneal ulcer-infiltrate associated with soft contact lens use following penetrating keratoplasty. (6399234)
1984
35
Corneal ulcer disease in Bangladesh. (6362524)
1983
36
Amikacin treatment of Pseudomonas-caused corneal ulcer. (6776941)
1980
37
Marginal corneal ulcers with acute beta streptococcal conjunctivitis and chronic dacryocystitis. (375740)
1979
38
Effect of dehydration on the healing of experimental corneal ulcer. (134359)
1976
39
Corneal ulcer due to Bacterium anitratum. (5642910)
1968
40
The corneal ulcer. VI. Surgical treatment. (5949549)
1966
41
Symposium: the corneal ulcer. I. Anatomy and physiology of the cornea of the dog. (5949545)
1966
42
The corneal ulcer. IV. Causes--miscellaneous. (5949548)
1966
43
MYCOBACTERIUM FORTUITUM; AS A CAUSE OF CORNEAL ULCER. (14333989)
1965
44
FUNGUS CORNEAL ULCER. (14077191)
1963
45
Corneal ulcer due to prolonged wearing of corneal contact lenses. (14478573)
1962
46
Amniotic membrane grafts in corneal ulcer. (13988766)
1962
47
Corneal ulcer due to Candida parapsilosis (C. parakrusei). (14420497)
1959
48
Peculiar type of corneal ulcer, associated with Candida mycoderma. (13559350)
1958
49
Streptokinase-streptodornase in the treatment of sloughing hypopyon corneal ulcers. (13313679)
1956
50
Corneal ulcer treated with streptomycin. (20997651)
1946

Genetic Variations for Corneal Ulcer

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Expression for genes affiliated with Corneal Ulcer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Ulcer

Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for genes affiliated with Corneal Ulcer

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53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Corneal Ulcer

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Corneal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5TAT
2(4-aminophenyl)mercuric acetate4410.4MMP3
3matrigel4410.2MMP3, CCL11
4rantes4410.2IL1B, CCL11
5butyrate4410.2CCL11, CCR3
6cyclosporin a44 28 5912.0NGF, CCL11, TAT
7hydrocortisone44 2 59 1112.9TAT, MMP2
8hematoxylin449.9MMP3, PRG2
9pge2449.8CCL11, MMP2, MMP9
10ilomastat449.7MMP3, MMP2, MMP9
11latanoprost44 1110.7MMP2, MMP3, MMP9
12hcec449.7MMP2, MMP3, NGF
13indomethacin44 59 28 1112.6PRG2, NGF, TAT
14uk 383367599.6MMP3, MMP2, MMP9
15gi 254023x599.6MMP3, MMP2, MMP9
16gm 6001599.6MMP2, MMP3, MMP9
17hydroxamate449.5MMP9, MMP2, MMP3
18marimastat44 59 1111.4MMP9, MMP2, MMP3
19doxycycline44 1110.4TAT, MMP9, MMP2, MMP3
20pdtc449.3MMP9, NGF, IL1B, MMP2
21celecoxib44 59 28 49 11 2414.2MMP9, MMP2, MMP3, IL1B
22groalpha449.2IL1B, IL10, CCL11
23ciglitazone44 2810.1IL1B, MMP2, MMP9
24ibuprofen44 28 49 11 2413.1MMP2, IL1B, IL10, MMP3
25pentoxifylline44 1110.1MMP2, TAT, IL1B, IL10
26troglitazone44 28 59 1112.1MMP9, MMP2, MMP3, IL1B, CCL11
27hyaluronic acid44 2410.0IL1B, MMP3, CCL11, MMP2, MMP9
28herbimycin a44 599.8IL1B, MMP9, CCL11, MMP2, NGF, CCR3
29dexamethasone44 49 28 1111.8TAT, CCL11, CCR3, MUC5AC, MMP9
30tgf beta1448.8MMP9, IL10, MMP3, MMP2, IL1B
31prednisolone44 28 1110.8MMP3, CCL11, NGF, IL10, TAT, MMP2
32ccl344 289.7CCL11, TAT, CCR3, MMP9, IL10, IL1B
33curcumin448.6MMP9, MMP3, IL1B, MMP2
34prostaglandin448.6IL1B, MUC5AC, MMP9, MMP3, CCL11
35ly294002448.6NGF, IL10, CCL11, MMP9, IL1B, MMP2
36alanine448.5CCL11, MMP9, CCR3, NGF, TAT, MMP3
37ribonucleic acid448.4IL1B, MMP9, MMP2, MMP3, MUC5AC
38actinomycin d448.3NGF, TAT, MMP9, IL1B, CCL11, CCR3
39n acetylcysteine448.2CCL11, MMP2, MMP3, MMP9, IL1B, MUC5AC
40pd 98,059448.2MMP3, MUC5AC, MMP9, MMP2, IL1B, NGF
41paraffin448.1MMP3, IL10, MMP2, MMP9, MUC5AC
42vegf447.9MMP9, NGF, IL10, IL1B, CCL11, TAT
43methotrexate44 49 119.7MMP2, MUC5AC, IL10, MMP9, TAT, IL1B
44genistein44 28 59 2 11 2412.5MMP9, MMP2, MMP3, TAT, IL1B, NGF
45sb 20358044 598.5CCL11, IL1B, MUC5AC, IL10, MMP3, MMP9
46cysteine447.4MMP2, CCR3, PRG2, NGF, MUC5AC, TAT
47tyrosine447.1PRG2, CCR3, CCL11, MUC5AC, TAT, MMP3
48calcium44 49 11 2410.1MMP2, MMP3, MUC5AC, NGF, PRG2, CCR3
49histamine44 28 249.0IL1B, CCL11, CCR3, PRG2, NGF, MMP3
50retinoic acid44 247.7MMP3, MMP9, MUC5AC, TAT, MMP2, NGF

GO Terms for genes affiliated with Corneal Ulcer

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16Gene Ontology
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Cellular components related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7PRG2, NGF, IL1B, MMP3, MMP2, MMP9
2extracellular spaceGO:0056157.2MMP9, CCL11, CCR3, NGF, IL10, IL1B

Biological processes related to Corneal Ulcer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.1CCR3, CCL11
2response to radiationGO:0093149.9NGF, CCL11
3eosinophil chemotaxisGO:0482459.8CCR3, CCL11
4ERK1 and ERK2 cascadeGO:0703719.6CCR3, CCL11
5collagen catabolic processGO:0305749.5MMP3, MMP2, MMP9
6response to glucocorticoid stimulusGO:0513849.5TAT, IL10, NGF
7embryo implantationGO:0075669.5IL1B, MMP2, MMP9
8positive regulation of angiogenesisGO:0457669.5CCL11, CCR3, IL1B
9extracellular matrix disassemblyGO:0226179.4MMP9, MMP2, MMP3
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL1B, IL10, NGF
11inflammatory responseGO:0069548.9IL1B, IL10, NGF, CCR3, CCL11

Molecular functions related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.4MMP9, MMP2, MMP3

Products for genes affiliated with Corneal Ulcer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corneal Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet