MCID: CRN028
MIFTS: 52

Corneal Ulcer malady

Eye diseases category

Summaries for Corneal Ulcer

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63Wikipedia, 32MalaCards
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Wikipedia:63 Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the... more...

MalaCards: Corneal Ulcer is related to keratoconjunctivitis and keratitis. An important gene associated with Corneal Ulcer is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Degradation of collagen and A-beta Plaque Formation & APP Metabolism . The drugs sulfacetamide and sulfisoxazole diolamine and the compounds cycloheximide and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and liver, and related mouse phenotypes are homeostasis/metabolism and respiratory system.

Aliases & Classifications for Corneal Ulcer

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

corneal ulcer 8 44 60


External Ids:

Disease Ontology8 DOID:8463
ICD9CM27 370.00, 370.0
MeSH34 D003320
NCIt39 C50515
ICD1025 H16.0

Related Diseases for Corneal Ulcer

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to corneal ulcer

Clinical Features for Corneal Ulcer

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Drugs & Therapeutics for Corneal Ulcer

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Corneal Ulcer

Drug clinical trials:

Search ClinicalTrials for Corneal Ulcer

Search NIH Clinical Center for Corneal Ulcer

Search CenterWatch for Corneal Ulcer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Corneal Ulcer

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Anatomical Context for Corneal Ulcer

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32MalaCards
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MalaCards organs/tissues related to Corneal Ulcer:

32
Eye, Bone, Liver, Skin, Testes, Endothelial

Animal Models for Corneal Ulcer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Corneal Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.1MUC5AC, NGF, CCR3
2MP:00053888.5CCL11, PRG2, MMP2, MMP9
3MP:00053876.3MMP9, CCL11, CCR3, PRG2, MUC5AC, IL10

Publications for Corneal Ulcer

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50PubMed
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Articles related to Corneal Ulcer:

(show top 50)    (show all 332)
idTitleAuthorsYear
1
Etiological agents of corneal ulcer: five years prospective study in eastern Nepal. (24047020)
2012
2
Contact-lens-related corneal ulcer caused by Klebsiella pneumoniae. (21915511)
2011
3
Outcome of penetrating keratoplasty in corneal ulcer: a single-center experience. (21966198)
2011
4
Contact lens--related corneal ulcer: a two-year review. (21488471)
2010
5
Detection and quantification of pathogenic bacteria and fungi using real-time polymerase chain reaction by cycling probe in patients with corneal ulcer. (20457973)
2010
6
Gatifloxacin, moxifloxacin, and balofloxacin resistance due to mutations in the gyrA and parC genes of Staphylococcus epidermidis strains isolated from patients with endophthalmitis, corneal ulcers and conjunctivitis. (19478540)
2009
7
Anti-inflammatory effects of topical supernatant from human amniotic membrane cell culture on canine deep corneal ulcer after human amniotic membrane transplantation. (19152595)
2009
8
Epidemiological characteristics, predisposing factors and microbiological profiles of infectious corneal ulcers: the Portsmouth corneal ulcer study. (19502241)
2009
9
Use of grid keratotomy for the treatment of indolent corneal ulcer in a llama. (17494370)
2007
10
Corneal ulcer as an atypical presentation of ocular cicatricial pemphigoid. (17294392)
2007
11
Isolation, vancomycin resistance and biofilm production of Staphylococcus epidermidis from patients with conjunctivitis, corneal ulcers, and endophthalmitis. (18293657)
2006
12
Fungal keratitis in patients with corneal ulcer in Sari, Northern Iran. (16859055)
2006
13
Rothia dentocariosa isolated from a corneal ulcer. (17133072)
2006
14
Effect of topical FK506 used alone or combined with keratoplasty on patients with recurrent Mooren's corneal ulcer. (17378150)
2006
15
Efficacy of two chondroitin sulfate ophthalmic solutions in the therapy of spontaneous chronic corneal epithelial defects and ulcerative keratitis associated with bullous keratopathy in dogs. (16497231)
2006
16
Amniotic membrane transplantation for reconstruction of corneal ulcer in graves ophthalmopathy. (15220741)
2004
17
Serratia Marcescens corneal ulcer as a complication of orthokeratology. (11476690)
2001
18
Conjunctival intraepithelial neoplasia presenting as corneal ulcer. (10653420)
2000
19
Moisture chamber for management of corneal ulcer due to Graves' ophthalmopathy. (11201860)
2000
20
Melting corneal ulcer management in a greater one-horned rhinoceros (Rhinoceros unicornis). (10884136)
2000
21
Use of Traditional Eye Medicines by corneal ulcer patients presenting to a hospital in South India. (16130279)
1999
22
Corneal ulcer caused by Nocardia asteroides in a patient with leprosy. (9542960)
1998
23
Acute onset transient ectropion associated with corneal ulcer. (9869340)
1997-1998
24
Therapy-resistant corneal ulcer in a six-year old patient. (9009360)
1996
25
Comparative study on topical and oral administration of ofloxacin for Pseudomonas corneal ulcer in rabbits. (7630623)
1995
26
Isolation of Kingella kingae from a corneal ulcer. (1401031)
1992
27
Candida albicans corneal ulcer associated with crack cocaine. (1992751)
1991
28
Corneal ulcer caused by Pseudomonas pseudomallei: report of three cases. (2041966)
1991
29
Serum zinc in corneal ulcer--a preliminary report. (1841890)
1991
30
Pseudomonas corneal ulcer after use of extended-wear rigid gas-permeable contact lens. (2501068)
1989
31
Pseudomonas corneal ulcer associated with disposable soft contact lenses. (2805313)
1989
32
Pseudomonas aeruginosa corneal ulcer associated with an aerosol can of preservative-free saline. Case report. (3142448)
1988
33
Comparative study of acyclovir and 5 I.D.U. in the management of viral corneal ulcer. (3508764)
1987
34
Corneal ulcer caused by Shigella flexneri in an infant. (3300355)
1987
35
Application of betadine (povidone iodine) to infected corneal ulcer. (3508763)
1987
36
Haemophilus influenzae corneal ulcer in a therapeutic contact lens wearer. (6607742)
1984
37
Norfloxacin and silver norfloxacin in the treatment of Pseudomonas corneal ulcer in the rabbit. (6242083)
1984
38
Corneal ulcer caused by a biologic insecticide (Bacillus thuringiensis). (6824057)
1983
39
Herpes simplex corneal ulcer. (6876890)
1983
40
Nocardia asteroides corneal ulcer. (7046451)
1982
41
Conjunctival, corneal involvement accompanying erosive-ulcerative blepharitis. (7213175)
1981
42
Pseudomonas corneal ulcer. The causative role of contaminated eye cosmetics. (112953)
1979
43
Lysozyme in corneal ulcer. (1200558)
1975
44
Subconjunctival nodules after amphotericin B injection. Medical therapy for Aspergillus corneal ulcer. (4126867)
1973
45
Shigella sonnei corneal ulcer. (4909699)
1970
46
DANGERS OF STEROIDS IN OPHTHALMOLOGY WITH REPORT OF A CASE OF MYCOTIC PERFORATING CORNEAL ULCER. (14125128)
1964
47
Pseudomonas corneal ulcer in a child. (13866171)
1961
48
Survey of the treatment of traumatic corneal ulcer, 1941-1944, Royal Hospital, Sheffield. (21018070)
1946
49
SURVEY OF THE TREATMENT OF TRAUMATIC CORNEAL ULCER: 1941-1944, Royal Hospital, Sheffield. (18170202)
1946
50
Corneal Ulcer - Its Treatment. (18742624)
1933

Genetic Variations for Corneal Ulcer

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Expression for genes affiliated with Corneal Ulcer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corneal Ulcer

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Pathways for genes affiliated with Corneal Ulcer

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53Reactome, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Corneal Ulcer

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Corneal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5TAT
2(4-aminophenyl)mercuric acetate4410.4MMP3
3matrigel4410.2MMP3, CCL11
4rantes4410.2IL1B, CCL11
5butyrate4410.2CCL11, CCR3
6cyclosporin a44 28 5912.0NGF, CCL11, TAT
7hydrocortisone44 2 59 1112.9TAT, MMP2
8hematoxylin449.9MMP3, PRG2
9pge2449.8CCL11, MMP2, MMP9
10ilomastat449.7MMP3, MMP2, MMP9
11latanoprost44 1110.7MMP2, MMP3, MMP9
12hcec449.7MMP2, MMP3, NGF
13indomethacin44 59 28 1112.6PRG2, NGF, TAT
14uk 383367599.6MMP3, MMP2, MMP9
15gi 254023x599.6MMP3, MMP2, MMP9
16gm 6001599.6MMP2, MMP3, MMP9
17hydroxamate449.5MMP9, MMP2, MMP3
18marimastat44 59 1111.4MMP9, MMP2, MMP3
19doxycycline44 1110.4TAT, MMP9, MMP2, MMP3
20pdtc449.3MMP9, NGF, IL1B, MMP2
21celecoxib44 59 28 49 11 2414.2MMP9, MMP2, MMP3, IL1B
22groalpha449.2IL1B, IL10, CCL11
23ciglitazone44 2810.1IL1B, MMP2, MMP9
24ibuprofen44 28 49 11 2413.1MMP2, IL1B, IL10, MMP3
25pentoxifylline44 1110.1MMP2, TAT, IL1B, IL10
26troglitazone44 28 59 1112.1MMP9, MMP2, MMP3, IL1B, CCL11
27hyaluronic acid44 2410.0IL1B, MMP3, CCL11, MMP2, MMP9
28herbimycin a44 599.8IL1B, MMP9, CCL11, MMP2, NGF, CCR3
29dexamethasone44 49 28 1111.8TAT, CCL11, CCR3, MUC5AC, MMP9
30tgf beta1448.8MMP9, IL10, MMP3, MMP2, IL1B
31prednisolone44 28 1110.8MMP3, CCL11, NGF, IL10, TAT, MMP2
32ccl344 289.7CCL11, TAT, CCR3, MMP9, IL10, IL1B
33curcumin448.6MMP9, MMP3, IL1B, MMP2
34prostaglandin448.6IL1B, MUC5AC, MMP9, MMP3, CCL11
35ly294002448.6NGF, IL10, CCL11, MMP9, IL1B, MMP2
36alanine448.5CCL11, MMP9, CCR3, NGF, TAT, MMP3
37ribonucleic acid448.4IL1B, MMP9, MMP2, MMP3, MUC5AC
38actinomycin d448.3NGF, TAT, MMP9, IL1B, CCL11, CCR3
39n acetylcysteine448.2CCL11, MMP2, MMP3, MMP9, IL1B, MUC5AC
40pd 98,059448.2MMP3, MUC5AC, MMP9, MMP2, IL1B, NGF
41paraffin448.1MMP3, IL10, MMP2, MMP9, MUC5AC
42vegf447.9MMP9, NGF, IL10, IL1B, CCL11, TAT
43methotrexate44 49 119.7MMP2, MUC5AC, IL10, MMP9, TAT, IL1B
44genistein44 28 59 2 11 2412.5MMP9, MMP2, MMP3, TAT, IL1B, NGF
45sb 20358044 598.5CCL11, IL1B, MUC5AC, IL10, MMP3, MMP9
46cysteine447.4MMP2, CCR3, PRG2, NGF, MUC5AC, TAT
47tyrosine447.1PRG2, CCR3, CCL11, MUC5AC, TAT, MMP3
48calcium44 49 11 2410.1MMP2, MMP3, MUC5AC, NGF, PRG2, CCR3
49histamine44 28 249.0IL1B, CCL11, CCR3, PRG2, NGF, MMP3
50retinoic acid44 247.7MMP3, MMP9, MUC5AC, TAT, MMP2, NGF

GO Terms for genes affiliated with Corneal Ulcer

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16Gene Ontology
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Cellular components related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7CCL11, PRG2, NGF, IL1B, MMP3, MMP2
2extracellular spaceGO:0056157.2CCL11, CCR3, NGF, IL10, IL1B, MMP3

Biological processes related to Corneal Ulcer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.1CCR3, CCL11
2response to radiationGO:0093149.9CCL11, NGF
3eosinophil chemotaxisGO:0482459.8CCR3, CCL11
4ERK1 and ERK2 cascadeGO:0703719.6CCR3, CCL11
5collagen catabolic processGO:0305749.5MMP3, MMP2, MMP9
6response to glucocorticoid stimulusGO:0513849.5NGF, IL10, TAT
7embryo implantationGO:0075669.5MMP9, IL1B, MMP2
8positive regulation of angiogenesisGO:0457669.5CCL11, CCR3, IL1B
9extracellular matrix disassemblyGO:0226179.4MMP9, MMP3, MMP2
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL1B, NGF, IL10
11inflammatory responseGO:0069548.9IL1B, IL10, NGF, CCR3, CCL11

Molecular functions related to Corneal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.4MMP9, MMP2, MMP3

Products for genes affiliated with Corneal Ulcer

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Corneal Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet