MCID: CRN028
MIFTS: 45

Corneal Ulcer malady

Categories: Eye diseases

Aliases & Classifications for Corneal Ulcer

Aliases & Descriptions for Corneal Ulcer:

Name: Corneal Ulcer 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8463
ICD10 33 H16.0 H16.00
ICD9CM 35 370.0 370.00
MeSH 42 D003320
NCIt 47 C50515
UMLS 69 C0010043

Summaries for Corneal Ulcer

MalaCards based summary : Corneal Ulcer is related to ectropion and cellulitis. An important gene associated with Corneal Ulcer is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Akt Signaling and Integrin Pathway. The drugs Miconazole and Natamycin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and bone, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the... more...

Related Diseases for Corneal Ulcer

Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
id Related Disease Score Top Affiliating Genes
1 ectropion 29.9 CCR1 MMP9
2 cellulitis 29.8 MMP3 MMP9
3 perforated corneal ulcer 12.1
4 central corneal ulcer 12.1
5 mycotic corneal ulcer 12.1
6 marginal corneal ulcer 12.1
7 ring corneal ulcer 12.1
8 dacryocystitis 11.1
9 corneal dystrophy, lattice type i 10.8
10 tyrosinemia, type ii 10.8
11 lymphedema-distichiasis syndrome 10.8
12 barre-lieou syndrome 10.8
13 neurotrophic keratopathy 10.8
14 keratomalacia 10.4
15 facio skeletal genital syndrome rippberger type 10.3 MMP2 MMP9
16 acute tricyclic antidepressant poisoning 10.3 MMP2 MMP9
17 leukoencephalopathy palmoplantar keratoderma 10.3 MMP2 MMP9
18 thymus adenocarcinoma 10.3 MMP2 MMP9
19 spinal meninges cancer 10.3 MMP2 MMP9
20 neonatal hypoxic and ischemic brain injury 10.3 MMP2 MMP9
21 senile atrophy of choroid 10.3 MMP2 MMP9
22 tinea profunda 10.3 MMP2 MMP9
23 toxic optic neuropathy 10.3 IL1B MMP9
24 viral meningitis 10.3 MMP2 MMP9
25 lymphocytic colitis 10.2 MMP2 MMP9
26 adenocarcinoma in situ 10.2 MMP2 MMP9
27 corneal staphyloma 10.2 MMP2 MMP9
28 linear porokeratosis 10.2 MMP2 MMP9
29 striated muscle rhabdoid tumor 10.2 MMP2 MMP9
30 maxillary neoplasm 10.2 MMP2 MMP9
31 breast papillary carcinoma 10.2 MMP2 MMP9
32 tinea capitis 10.2 IL1B NGF
33 adenoid squamous cell carcinoma 10.2 MMP2 MMP9
34 onychocytic matricoma 10.2 MMP2 MMP9
35 trichomalacia 10.2 MMP2 MMP9
36 gastroduodenal crohn's disease 10.2 IL1B NGF
37 right atrium familial dilatation 10.2 MMP3 MMP9
38 central nervous system adult germ cell tumor 10.2 MMP3 MMP9
39 mikulicz disease 10.2 IL1B NGF
40 retinal drusen 10.2 MMP2 MMP9
41 severe acute respiratory syndrome 10.1 MMP2 MMP9
42 cystic lymphangioma 10.1 MMP3 MMP9
43 appendix carcinoid tumor 10.1 MMP2 MMP9 NGF
44 adult neuronal ceroid lipofuscinosis 10.1 MMP2 MMP9 NGF
45 angiomyoma 10.1 MMP2 MMP3
46 bulbomembranous urethral cancer 10.1 IL1B MMP2 MMP9
47 urea cycle disorder 10.1 IL1B NGF
48 laryngostenosis 10.1 MMP2 MMP9
49 natural killer cell leukemia 10.1 CCL11 MMP9
50 thelaziasis 10.1 CCL11 MMP9

Comorbidity relations with Corneal Ulcer via Phenotypic Disease Network (PDN):


Bullous Keratopathy Cicatricial Pemphigoid
Hypertension, Essential Hypopyon Ulcer
Perforated Corneal Ulcer Purulent Endophthalmitis

Graphical network of the top 20 diseases related to Corneal Ulcer:



Diseases related to Corneal Ulcer

Symptoms & Phenotypes for Corneal Ulcer

MGI Mouse Phenotypes related to Corneal Ulcer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 CCR1 IFT122 IL1B MMP2 MMP9 NGF
2 hematopoietic system MP:0005397 9.8 CCL11 CCR1 CCR3 IL1B MMP2 MMP3
3 homeostasis/metabolism MP:0005376 9.76 CCR1 CCR3 IFT122 IL1B MMP2 MMP3
4 immune system MP:0005387 9.5 CCL11 CCR1 CCR3 IL1B MMP2 MMP3
5 respiratory system MP:0005388 9.02 CCL11 CCR1 CCR3 MMP2 MMP9

Drugs & Therapeutics for Corneal Ulcer

Drugs for Corneal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 189)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
2
Natamycin Approved Phase 4,Phase 3,Phase 1,Phase 2 7681-93-8 5281099
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
5
Ephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 299-42-3 9294
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
7
Moxifloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 354812-41-2, 151096-09-2 152946
8
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 90-82-4 7028
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
10
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
11
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
12
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 83-88-5 493570
13 Tetrahydrozoline Phase 4,Phase 3,Phase 1,Phase 2
14 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
15 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
16 Hormones Phase 4,Phase 3,Phase 1,Phase 2
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2
19 Vasoconstrictor Agents Phase 4,Phase 3,Phase 1,Phase 2
20 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
21 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1
24 Antifungal Agents Phase 4,Phase 3,Phase 1,Phase 2
25 Respiratory System Agents Phase 4,Phase 3,Phase 1,Phase 2
26 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1
27 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2
28 Antiparasitic Agents Phase 4,Phase 2,Phase 3
29 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
30 Prednisolone acetate Phase 4,Phase 3
31 Dexamethasone acetate Phase 4 1177-87-3
32 glucocorticoids Phase 4,Phase 3,Phase 2
33
protease inhibitors Phase 4,Phase 2,Phase 3
34 Mitogens Phase 4,Phase 1,Phase 2
35 Nasal Decongestants Phase 4,Phase 3,Phase 1,Phase 2
36 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
37 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
38 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3,Phase 2
39 Dermatologic Agents Phase 4,Phase 3,Phase 1,Phase 2
40 Dexamethasone 21-phosphate Phase 4
41 Prednisolone hemisuccinate Phase 4,Phase 3
42 Prednisolone phosphate Phase 4,Phase 3
43 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
44 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Antiemetics Phase 4,Phase 3
46 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
47 Lubricant Eye Drops Phase 4,Phase 1
48 Methylprednisolone acetate Phase 4,Phase 3
49 Methylprednisolone Hemisuccinate Phase 4,Phase 3
50 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 85)
id Name Status NCT ID Phase
1 Steroids for Corneal Ulcers Trial Completed NCT00324168 Phase 4
2 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4
3 Cross-linking for Corneal Ulcers Treatment Trial Recruiting NCT02570321 Phase 4
4 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4
5 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4
6 Low Dose Doxycycline in the Treatment of Corneal Burn Unknown status NCT01886560 Phase 2, Phase 3
7 Mycotic Ulcer Treatment Trial I Completed NCT00996736 Phase 3
8 Comparison Between Bandage Contact Lens and Pressure Patching for The Erosion Area and Pain Scale in Corneal Erosion Patients Completed NCT01809483 Phase 3
9 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3
10 Study of Rebamipide Eye Drops to Treat Dry Eye Completed NCT00201981 Phase 3
11 Study of Rebamipide Eye Drops to Treat Dry Eye Completed NCT00201955 Phase 3
12 Efficacy and Safety of Rebamipide in Subjects With Dry Eye Syndrome Completed NCT01632137 Phase 3
13 Long Term Administration Study of OPC-12759 Ophthalmic Suspension Completed NCT00818324 Phase 3
14 Confirmatory Study of OPC-12759 Ophthalmic Suspension Completed NCT00885079 Phase 3
15 Confirmatory Study of OPC-12759 Ophthalmic Solution Completed NCT01660256 Phase 3
16 Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome Completed NCT00198536 Phase 2, Phase 3
17 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Recruiting NCT01794312 Phase 3
18 Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis Recruiting NCT02717871 Phase 3
19 Effectiveness of Corneal Accelerated Crosslinking for Infectious Keratitis Recruiting NCT02865876 Phase 3
20 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3
21 Mycotic Ulcer Treatment Trial II Active, not recruiting NCT00997035 Phase 3
22 Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis Active, not recruiting NCT01751126 Phase 3
23 Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood Enrolling by invitation NCT02153515 Phase 3
24 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Enrolling by invitation NCT02731638 Phase 3
25 A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine Terminated NCT00516399 Phase 3
26 Effect of Tetracaine on Pain Management and Corneal Healing in Patients With Acute Corneal Abrasion Terminated NCT02483897 Phase 3
27 Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease Withdrawn NCT01753596 Phase 3
28 A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers Completed NCT00386958 Phase 2
29 Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers Completed NCT00651586 Phase 2
30 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed NCT01756456 Phase 1, Phase 2
31 Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer Completed NCT00557362 Phase 1, Phase 2
32 Collagen Cross-linking in Infectious Keratitis Trial Completed NCT01831206 Phase 2
33 Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye Completed NCT01393132 Phase 2
34 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2
35 NSAID Phase II for Non-central Involved Diabetic Macular Edema (DME) Completed NCT01331005 Phase 2
36 Late Phase 2 Study of OPC-12759 Ophthalmic Suspension Completed NCT00475319 Phase 2
37 Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Subjects With Dry Eye - Effects on Central Cornea Completed NCT01057147 Phase 2
38 Dose-response Study of OPC-12759 Ophthalmic Suspension Completed NCT00234078 Phase 2
39 Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye Completed NCT01027013 Phase 2
40 Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease Completed NCT00667004 Phase 2
41 Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome Completed NCT00370747 Phase 2
42 Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment Recruiting NCT01765244 Phase 1, Phase 2
43 Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 Neurotrophic Keratitis Recruiting NCT02227147 Phase 2
44 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis Recruiting NCT01582880 Phase 1, Phase 2
45 Corneal Collagen Crosslinking to Increase the Resistance of the Support Graft of the KPro Type I Against Corneal Melting Recruiting NCT03041883 Phase 1, Phase 2
46 Autologous Platelet Lysate in Corneal Epithelial Defects Recruiting NCT02979912 Phase 1, Phase 2
47 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2
48 A Comparison of Three Fluoroquinolone Topical Eyedrops in the Treatment of Infectious Corneal Ulcers. Terminated NCT01928693 Phase 2
49 Infliximab to Improve Retention of the Boston Keratoprosthesis in Patients After Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis (SJS/TENS) Withdrawn NCT01256489 Phase 1, Phase 2
50 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1

Search NIH Clinical Center for Corneal Ulcer

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: corneal ulcer

Genetic Tests for Corneal Ulcer

Anatomical Context for Corneal Ulcer

MalaCards organs/tissues related to Corneal Ulcer:

39
Eye, Testes, Bone, Liver

Publications for Corneal Ulcer

Articles related to Corneal Ulcer:

(show top 50) (show all 346)
id Title Authors Year
1
Spontaneous Corneal Hydrops in a Patient with a Corneal Ulcer. ( 26889160 )
2016
2
Corneal Ulcer Leading to Evisceration or Enucleation in a Tertiary Eye Care Center in Thailand: Clinical and Microbiological Characteristics. ( 27266225 )
2016
3
Orbital cellulitis and corneal ulcer due to Cedecea: First reported case and review of the literature. ( 27070554 )
2016
4
An unusual case of spontaneous Mycobacterium chelonae corneal ulcer in a healthy middle-aged adult. ( 27274315 )
2016
5
Acacia honey accelerates in vitro corneal ulcer wound healing model. ( 27473120 )
2016
6
Bacterial corneal ulcer associated with common variable immune deficiency. ( 27491761 )
2016
7
Outcome of Urgent Penetrating Keratoplasty for Corneal Ulcer at Thammasat University Hospital. ( 27455827 )
2016
8
A Novel Tectonic Keratoplasty with Femtosecond Laser Intrastromal Lenticule for Corneal Ulcer and Perforation. ( 27453231 )
2016
9
Rare case of bilateral perforated corneal ulcer due to gonococcal infection, managed with temporary periosteal graft. ( 26907819 )
2016
10
Diagnosis and Treatment of Pythium Insidiosum Corneal Ulcer in a Chinese Child: A Case Report and Literature Review. ( 28025573 )
2016
11
Fungal keratitis in patients with corneal ulcer attending Minilik II Memorial Hospital, Addis Ababa, Ethiopia. ( 27576913 )
2016
12
Acquired anterior staphyloma after corneal ulcer associated with the use of crack. ( 27626156 )
2016
13
Microbiological profile of corneal ulcer cases diagnosed in a tertiary care ophthalmological institute in Nepal. ( 27899093 )
2016
14
Management of Infective Corneal Ulcer: Epidemiology Needs To Be Evaluated As Priority Basis. ( 27612884 )
2016
15
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )
2016
16
Epidemiological Aspect and common Bacterial and Fungal isolates from Suppurative Corneal Ulcer in Mymensingh Region. ( 26007250 )
2015
17
Experimental study on cryotherapy for fungal corneal ulcer. ( 25880872 )
2015
18
Pink hypopyon in a patient with Serratia marcescens corneal ulceration. ( 25861400 )
2015
19
Bilateral sterile perforated corneal ulcer in an HIV case. ( 26265852 )
2015
20
Night market contact lens-related corneal ulcer: Should we increase public awareness? ( 26425295 )
2015
21
Community practice patterns for bacterial corneal ulcer evaluation and treatment. ( 25536529 )
2015
22
Corneal ulcer? Think beyond only a bacterial etiology. ( 25609872 )
2015
23
Treatment of Acanthamoeba neurotrophic corneal ulcer with topical matrix therapy. ( 26101555 )
2015
24
Long-term efficacy of glycerine-processed amniotic membrane transplantation in patients with corneal ulcer. ( 25773445 )
2015
25
Alpha-1-antitrypsin associated panniculitis and corneal ulcer with a rare allelic variant (PiFZ): a case report. ( 26474730 )
2015
26
Corneal ulcer caused by nocardia brasiliensis in a patient with diabetes. ( 24790888 )
2014
27
The corneal ulcer one-touch study: a simplified microbiological specimen collection method. ( 25244977 )
2014
28
Acinetobacter junii as an aetiological agent of corneal ulcer. ( 25056128 )
2014
29
In Vitro Antibiotic Susceptibility of Pseudomonas aeruginosa Corneal Ulcer Isolates. ( 24564536 )
2014
30
Simultaneous study of matrix metalloproteinases, proinflammatory cytokines, and soluble cytokine receptors in the tears of noninfectious corneal ulcer patients. ( 25005620 )
2014
31
Repositioning of pedicle conjunctival flap performed for refractory corneal ulcer. ( 24669154 )
2014
32
Antibiotic susceptibility pattern of bacteria isolated from corneal ulcer in a tertiary level eye hospital. ( 26402978 )
2014
33
In vitro susceptibility of filamentous fungal isolates from a corneal ulcer clinical trial. ( 24439440 )
2014
34
Complementary treatment of contact lens-induced corneal ulcer using honey: A case report. ( 25278429 )
2014
35
Cunninghamella spinosum fungal corneal ulcer- first case report. ( 24722275 )
2014
36
Efficacy of Gatifloxacin in Acute Bacterial Corneal ulcer. ( 24550957 )
2013
37
Cost evaluation of corneal ulcer treatment. ( 23691700 )
2013
38
Evaluation of risk factors for development of corneal ulcer after nonocular surgery in dogs: 14 cases (2009-2011). ( 23683020 )
2013
39
Fungal corneal ulcer and bacterial orbital cellulitis occur as complications of bacterial endophthalmitis after cataract surgery in an immunocompetent patient. ( 23448560 )
2013
40
Ultraviolet A and riboflavin therapy as an adjunct in corneal ulcer refractory to medical treatment. ( 24172067 )
2013
41
Collagen cross-linking for resistant corneal ulcer. ( 23015020 )
2013
42
A clinical microbiological study of corneal ulcer patients at western Gujarat, India. ( 23852845 )
2013
43
Demographic patterns of ED patients diagnosed as having corneal ulcer. ( 23688560 )
2013
44
Bilateral corneal ulceration in ocular graft-versus-host disease. ( 24204119 )
2013
45
Abiotrophia defectiva causing infectious crystalline keratopathy and corneal ulcer after penetrating keratoplasty: a case report. ( 23514629 )
2013
46
An environmental Sporothrix as a cause of corneal ulcer. ( 24432225 )
2013
47
Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). ( 21987582 )
2012
48
Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea. ( 22531699 )
2012
49
Organism isolation in corneal ulcer: utility of different techniques. ( 23279767 )
2012
50
Streptococcal pharyngitis leading to corneal ulceration. ( 22360434 )
2012

Variations for Corneal Ulcer

Expression for Corneal Ulcer

Search GEO for disease gene expression data for Corneal Ulcer.

Pathways for Corneal Ulcer

Pathways related to Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 CCL11 CCR1 CCR3 IL1B NGF
2
Show member pathways
13.05 CCL11 CCR1 CCR3 MMP2 MMP3 MMP9
3
Show member pathways
13.02 CCL11 CCR1 CCR3 IL1B NGF
4
Show member pathways
12.99 CCL11 CCR1 IL1B MMP2 MMP3 MMP9
5
Show member pathways
12.53 IL1B MMP2 MMP9 NGF
6
Show member pathways
11.96 CCL11 IL1B MMP3 MMP9
7 11.86 IL1B MMP2 MMP9
8
Show member pathways
11.79 CCL11 CCR1 CCR3
9 11.73 MMP2 MMP3 MMP9
10 11.7 IL1B MMP3 MMP9
11
Show member pathways
11.65 MMP2 MMP3 MMP9
12 11.57 MMP2 MMP3 MMP9
13 11.41 CCL11 IL1B MMP2 MMP3 MMP9
14 11.33 MMP2 MMP3 MMP9
15 11.31 CCR1 IL1B
16 11.3 MMP2 MMP9
17
Show member pathways
11.26 MMP2 MMP9
18
Show member pathways
11.26 IL1B MMP2 MMP3 MMP9
19 11.2 MMP3 MMP9
20 11.14 MMP2 MMP9
21 11.12 MMP2 MMP9
22 10.99 MMP2 MMP9
23 10.98 MMP2 MMP9
24 10.83 CCR3 IL1B MMP9
25 10.82 CCL11 CCR3 IL1B MMP2 MMP9

GO Terms for Corneal Ulcer

Cellular components related to Corneal Ulcer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CCL11 IL1B MMP2 MMP3 MMP9
2 extracellular region GO:0005576 9.1 CCL11 IL1B MMP2 MMP3 MMP9 NGF

Biological processes related to Corneal Ulcer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.63 CCL11 CCR1 MMP9
2 inflammatory response GO:0006954 9.62 CCL11 CCR1 CCR3 IL1B
3 chemotaxis GO:0006935 9.61 CCL11 CCR1 CCR3
4 positive regulation of angiogenesis GO:0045766 9.54 CCL11 CCR3 IL1B
5 endodermal cell differentiation GO:0035987 9.48 MMP2 MMP9
6 extracellular matrix disassembly GO:0022617 9.43 MMP2 MMP3 MMP9
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.4 MMP2 MMP9
8 chemokine-mediated signaling pathway GO:0070098 9.33 CCL11 CCR1 CCR3
9 collagen catabolic process GO:0030574 9.13 MMP2 MMP3 MMP9
10 embryo implantation GO:0007566 8.8 IL1B MMP2 MMP9

Molecular functions related to Corneal Ulcer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.54 MMP2 MMP3 MMP9
2 metallopeptidase activity GO:0008237 9.5 MMP2 MMP3 MMP9
3 metalloendopeptidase activity GO:0004222 9.33 MMP2 MMP3 MMP9
4 chemokine receptor activity GO:0004950 9.26 CCR1 CCR3
5 C-C chemokine receptor activity GO:0016493 8.96 CCR1 CCR3
6 C-C chemokine binding GO:0019957 8.62 CCR1 CCR3

Sources for Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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