MCID: CRN006
MIFTS: 48

Coronary Aneurysm malady

Cardiovascular diseases category

Summaries for Coronary Aneurysm

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66Wikipedia, 34MalaCards
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Wikipedia:66 Coronary artery aneurysm is an abnormal dilatation of part of the coronary artery. more...

MalaCards: Coronary Aneurysm, also known as arteriovenous aneurysm of coronary vessels, is related to systemic lupus erythematosus and pneumonia. An important gene associated with Coronary Aneurysm is LDB3 (LIM domain binding 3), and among its related pathways are TRAF Pathway and Cellular Transformation by HTLV1. The compounds rantes and d-galactosamine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and lymph node, and related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Aliases & Classifications for Coronary Aneurysm

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9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

coronary aneurysm 9 11 63
arteriovenous aneurysm of coronary vessels 9
aneurysmal lesion of coronary artery 9
aneurysm of coronary vessels 9


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Disease Ontology9 DOID:3362
ICD9CM28 414.11
SNOMED-CT59 50570003, 373139003
MeSH36 D003323

Related Diseases for Coronary Aneurysm

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18GeneCards, 19GeneDecks
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Diseases related to Coronary Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.2LTA, IL10, TNF
2pneumonia30.0IL10, TNF
3arthritis29.9LTA, IL10, TNF
4rheumatoid arthritis29.9TNF, IL10, LTA
5aneurysm11.2
6kawasaki disease10.9
7myocardial infarction10.7
8acute myocardial infarction10.6
9polyarteritis nodosa10.3
10arteriovenous fistula10.2
11polycystic kidney disease10.2
12churg-strauss syndrome10.2
13kidney disease10.2
14lupus erythematosus10.2
15hypereosinophilic syndrome10.2
16blau syndrome10.1TNF
17psoriatic arthritis10.1TNF
18leishmaniasis10.1IL10
19toxic shock syndrome10.0TNF, LTA
20pulmonary sarcoidosis10.0LTA, TNF
21juvenile rheumatoid arthritis10.0TNF, LTA
22adult respiratory distress syndrome10.0TNF, LTA
23behcet's disease10.0TNF, LTA
24alcoholic hepatitis10.0GPT, TNF
25hypertriglyceridemia10.0GPT, LTA
26sarcoidosis10.0LTA, TNF
27primary biliary cirrhosis10.0LTA, GPT
28galactosemia10.0TNF, IL10
29selective iga deficiency disease10.0LTA, IL10
30lepromatous leprosy10.0IL10, LTA
31neurofibromatosis10.0
32cardiac tamponade10.0
33supravalvular aortic stenosis10.0
34intracranial aneurysm10.0
35takayasu's arteritis10.0
36lyme disease10.0
37hemopericardium10.0
38silent myocardial infarction10.0
39pericardial effusion10.0
40pericarditis10.0
41aortic coarctation10.0
42chronic active epstein-barr virus infection10.0
43fibromuscular dysplasia10.0
44microscopic polyangiitis10.0
45syncope10.0
46endotheliitis10.0
47coronary arterial fistulas10.0
48visceral leishmaniasis10.0IL10, LTA
49cerebral malaria10.0TNF, IL10
50coronary artery disease10.0LTA, LDB3

Graphical network of the top 20 diseases related to Coronary Aneurysm:



Diseases related to coronary aneurysm

Symptoms for Coronary Aneurysm

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Drugs & Therapeutics for Coronary Aneurysm

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Coronary Aneurysm

Drug clinical trials:

Search ClinicalTrials for Coronary Aneurysm

Search NIH Clinical Center for Coronary Aneurysm

Search CenterWatch for Coronary Aneurysm

Genetic Tests for Coronary Aneurysm

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Anatomical Context for Coronary Aneurysm

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34MalaCards
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MalaCards organs/tissues related to Coronary Aneurysm:

34
Heart, Kidney, Lymph node, Endothelial

Animal Models for Coronary Aneurysm or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Coronary Aneurysm:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6LTA, IL10, TNF
2MP:00053708.3LTA, IL10, TNF
3MP:00053888.3LTA, IL10, LDB3, TNF
4MP:00053858.2TNF, LDB3, IL10, LTA
5MP:00053788.2LTA, IL10, LDB3, TNF
6MP:00053868.1TNF, LDB3, IL10, LTA

Publications for Coronary Aneurysm

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Sources:
53PubMed
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Articles related to Coronary Aneurysm:

(show top 50)    (show all 217)
idTitleAuthorsYear
1
Bilateral giant coronary aneurysms in Kawasaki disease: how difficult can it be? (24218442)
2013
2
Bentall procedure for an adult patient with supravalvular aortic stenosis and coronary aneurysms. (23879341)
2013
3
Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in a Pediatric Patient with Giant Coronary Aneurysm Due to Kawasaki Disease. (23601472)
2013
4
Coronary Artery Bypass Grafting in a Patient with Polyarteritis Nodosa Presenting with Acute Myocardial Infarction and Multiple Coronary Aneurysms. (23995351)
2013
5
National Japanese survey of thrombolytic therapy selection for coronary aneurysm: Intracoronary thrombolysis or intravenous coronary thrombolysis in patients with Kawasaki disease. (23919576)
2013
6
Intracoronary thrombus in an infant with Kawasaki disease and giant coronary aneurysm. (23368954)
2013
7
Rare insight into the rapid evolution of a coronary aneurysm and fistula. (24076292)
2013
8
Reversible stenosis of the saphenous vein graft compressed by giant coronary aneurysm in Kawasaki disease. (23660427)
2013
9
Coronary aneurysm formation following biodegradable polymer drug-eluting stent implantation. (22257689)
2012
10
Rapidly evolving coronary aneurysm in a patient with rheumatoid arthritis. (21403892)
2011
11
Myocardial infarction in a youngster due to giant coronary aneurysm. (21351229)
2011
12
Coronary aneurysm with double right coronary artery and fistula. (21241866)
2011
13
Very late coronary aneurysm formation with subsequent stent thrombosis secondary to drug-eluting stent. (22088549)
2011
14
Case images: giant coronary aneurysm accompanied by a coronary artery fistula. (20935441)
2010
15
Impressive combination of multiple sinus valsalvae and coronary aneurysms due to hypereosinophilic syndrome. (20971227)
2010
16
Usefulness of cardio MRI on thrombosis of coronary aneurysm as an infrequent cause of ST-elevation coronary syndrome. (19278742)
2010
17
Natural history of a giant coronary aneurysm with spontaneous dissection. (20014206)
2009
18
Giant coronary aneurysm in a patient with systemic lupus erythematosus. (19687588)
2009
19
Left anterior descending coronary aneurysm. (19515889)
2009
20
Cardiovascular images. Giant right coronary aneurysm to left ventricular fistula. (19808583)
2009
21
Case report: Giant coronary aneurysm caused by Kawasaki disease: follow-up with echocardiography and multidetector CT angiography. (18344266)
2008
22
Coronary aneurysm in Lyme Disease: treatment by covered stent. (17692941)
2008
23
Coronary aneurysm formation in a patient early after everolimus-eluting stent implantation. (18460723)
2008
24
Rapid development of late stent malappositon and coronary aneurysm following implantation of a paclitaxel-eluting coronary stent. (17442215)
2007
25
Late stent thrombosis associated with coronary aneurysm formation after sirolimus-eluting stent implantation. (17404416)
2007
26
Development of coronary aneurysm after drug-eluting stent implantation. (17283357)
2007
27
Giant coronary aneurysm following drug-eluting stent implantation presenting as fever of unknown origin. (17620677)
2007
28
Images in cardiovascular medicine. The use of 2 contrast filling patterns in the diagnosis of a giant coronary aneurysm. (17502579)
2007
29
Noninvasive evaluation of left circumflex coronary aneurysm by real-time three-dimensional echocardiography. (15908280)
2006
30
Images in cardiology: giant coronary aneurysm in the septal branch. (16287752)
2005
31
Polytetrafluoroethylene stent deployment for a left anterior descending coronary aneurysm complicated by late acute anterior myocardial infarction. (16061748)
2005
32
Percutaneous treatment of a large coronary aneurysm using the self-expandable Symbiot PTFE-covered stent. (15302758)
2004
33
Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study. (15482602)
2004
34
Stent implantation for coronary aneurysm with edge stenosis: angiographic and intravascular analysis. (15152166)
2004
35
Treatment of coronary aneurysm in acute myocardial infarction with AngioJet thrombectomy and JoStent coronary stent graft. (15152122)
2004
36
Surgical treatment of annuloaortic ectasia with coronary aneurysm and fistula. (11426789)
2001
37
Large atherosclerotic left main coronary aneurysm--a case report and review of the literature. (11515991)
2001
38
A coronary aneurysm complicated by acute myocardial infarction. A case report. (11292909)
2001
39
Intraseptal coronary aneurysm. (10969706)
2000
40
Transthoracic ultrasonic visualisation of coronary aneurysm, stenosis, and occlusion in Kawasaki disease. (10722537)
2000
41
Morphologic and functional assessment of coronary aneurysm after Kawasaki disease by repeated dipyridamole-loading coronary angiography. (9708673)
1998
42
Recurrent myocardial infarction caused by a giant coronary aneurysm. (9578359)
1998
43
Coronary aneurysm after bailout stent implantation: diagnosis of a false lumen with intravascular ultrasound. (9258484)
1997
44
Anticoagulant therapy during successful pregnancy and delivery in a Kawasaki disease patient with coronary aneurysm--a case report. (9070977)
1997
45
Plaque rupture as a cause of apparent coronary aneurysm formation following directional coronary atherectomy. (9143766)
1997
46
Development of a coronary aneurysm 6 months after stent implantation assessed by intracoronary ultrasound. (8721665)
1996
47
Long-term prognosis of giant coronary aneurysm in Kawasaki disease: an angiographic study. (3668739)
1987
48
Predictive factors of coronary aneurysm in Kawasaki disease--correlation between coronary arterial lesions and serum albumin, cholinesterase activity, prealbumin, retinol-binding protein and immature neutrophils. (3423065)
1987
49
Coronary aneurysm: isolated necrotizing angitis of a major coronary artery. Report of a case. (4149915)
1974
50
Coronary aneurysm with arteriovenous fistula. (13180479)
1954

Variations for Coronary Aneurysm

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Expression for genes affiliated with Coronary Aneurysm

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coronary Aneurysm

Search GEO for disease gene expression data for Coronary Aneurysm.

Pathways for genes affiliated with Coronary Aneurysm

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters, 55R&D Systems, 58SinoBiological
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Pathways related to Coronary Aneurysm according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4TNF, LTA
2
Show member pathways
9.4LTA, TNF
3
Show member pathways
9.4LTA, TNF
4
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.4LTA, TNF
59.4LTA, TNF
6
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.4LTA, TNF
7
Show member pathways
9.4LTA, TNF
8
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.4LTA, TNF
9
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.4TNF, LTA
10
Show member pathways
9.4LTA, TNF
119.4LTA, TNF
129.1LTA, IL10
139.1LTA, IL10
149.1TNF, IL10
15
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.1IL10, TNF
169.1IL10, TNF
179.1TNF, IL10
189.1TNF, IL10
19
Show member pathways
9.1IL10, TNF
209.1IL10, TNF
219.1IL10, TNF
229.1TNF, IL10
23
Show member pathways
8.6TNF, IL10, LTA
24
Show member pathways
IL27-mediated signaling events39
8.6LTA, IL10, TNF
25
Show member pathways
8.6LTA, IL10, TNF
268.6LTA, IL10, TNF
27
Show member pathways
8.6LTA, IL10, TNF
28
Show member pathways
8.6LTA, IL10, TNF
29
Show member pathways
8.6LTA, IL10, TNF
30
Show member pathways
8.6TNF, IL10, LTA

Compounds for genes affiliated with Coronary Aneurysm

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Coronary Aneurysm according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1rantes4610.0IL10
2d-galactosamine469.7TNF, GPT
3nash469.7GPT, TNF
4cdp571469.5IL10, TNF
5interferon gamma469.5IL10, TNF
6blys469.5IL10, TNF
7gabexate mesilate469.5IL10, TNF
8ulinastatin469.5IL10, TNF
9mip 1alpha469.5IL10, TNF
10natalizumab46 1210.5IL10, TNF
115 aminosalicylic acid469.4TNF, IL10
12il-12469.4TNF, IL10
13adalimumab46 52 1211.4IL10, TNF
14indoleamine469.4IL10, TNF
15imiquimod46 62 30 1212.4TNF, IL10
16polymyxin b469.4IL10, TNF
176 mercaptopurine469.3IL10, GPT
18groalpha469.3IL10, TNF
19gm-csf46 3010.3TNF, IL10
208-isoprostane469.2IL10, TNF
21lamivudine46 52 1211.2IL10, GPT
22toxin-1469.1TNF, IL10, LTA
23cyclosporine52 1210.1LTA, IL10, TNF
24okt3469.0LTA, IL10, TNF
25lipoteichoic acid469.0TNF, IL10, LTA
26etanercept46 52 1211.0TNF, IL10, LTA
27il 10469.0LTA, IL10, TNF
28infliximab46 52 1211.0LTA, IL10, TNF
29polyinosinic-polycytidylic acid469.0IL10, TNF
30risperidone46 52 30 62 25 1214.0IL10, GPT
31pentoxifylline46 1210.0TNF, IL10, LTA
32tgf beta1469.0TNF, IL10, LTA
33endotoxin469.0TNF, IL10, LTA
34ionomycin469.0LTA, IL10, TNF
35calcitriol46 62 25 1212.0TNF, IL10, LTA
362,5-oligoadenylate468.9IL10, TNF, GPT
37atorvastatin46 52 30 25 1212.9GPT, TNF, IL10
38simvastatin46 52 62 30 25 1213.9IL10, TNF, GPT
39thyroxine46 259.9LTA, IL10, GPT
40tacrolimus46 52 1210.9IL10, TNF, GPT
41methotrexate52 46 1210.9GPT, TNF, IL10
42rolipram46 62 3010.8IL10, TNF
43vitamin d468.8LTA, IL10, GPT
44lactate468.8GPT, TNF, LTA
45pge2468.7LTA, IL10, TNF
46mycophenolate mofetil46 52 1210.4LTA, IL10, TNF, GPT
47ivig468.4GPT, TNF, IL10, LTA
48neopterin468.4GPT, TNF, IL10, LTA
49prednisolone46 30 1210.4LTA, IL10, TNF, GPT
50cyclosporin a46 30 6210.4LTA, IL10, TNF, GPT

GO Terms for genes affiliated with Coronary Aneurysm

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17Gene Ontology
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Cellular components related to Coronary Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6LTA, IL10, TNF

Biological processes related to Coronary Aneurysm according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.7LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.7LTA, TNF
3cellular amino acid biosynthetic processGO:0086529.6TNF, GPT
4defense response to Gram-positive bacteriumGO:0508309.5LTA, TNF
5positive regulation of interferon-gamma productionGO:0327299.5TNF, LTA
6humoral immune responseGO:0069599.4LTA, TNF
7response to hypoxiaGO:0016669.4LTA, TNF
8receptor biosynthetic processGO:0328009.4IL10, TNF
9negative regulation of cytokine secretion involved in immune responseGO:0027409.4TNF, IL10
10negative regulation of interleukin-6 productionGO:0327159.4IL10, TNF
11positive regulation of cytokine secretionGO:0507159.3IL10, TNF
12response to activityGO:0148239.3IL10, TNF
13response to glucocorticoidGO:0513849.0IL10, TNF
14negative regulation of growth of symbiont in hostGO:0441308.9LTA, IL10, TNF
15positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.8IL10, TNF
16response to drugGO:0424938.8TNF, IL10, LTA

Molecular functions related to Coronary Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.4LTA, TNF
2cytokine activityGO:0051258.3LTA, IL10, TNF

Products for genes affiliated with Coronary Aneurysm

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coronary Aneurysm

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet