MCID: CRN029
MIFTS: 45

Coronary Arteriosclerosis malady

Summaries for Coronary Arteriosclerosis

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of... more...

MalaCards: Coronary Arteriosclerosis is related to arteriosclerosis and coronary heart disease. An important gene associated with Coronary Arteriosclerosis is VCL (vinculin), and among its related pathways are Syndecan-1-mediated signaling events and Scavenging by Class B Receptors. The compounds cycloheximide and herbimycin a have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and muscle.

Aliases & Classifications for Coronary Arteriosclerosis

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

coronary arteriosclerosis 8 61


External Ids:

Disease Ontology8 DOID:3363
NCIt40 C35505
MeSH35 D003324
ICD9CM27 414.0

Related Diseases for Coronary Arteriosclerosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Coronary Arteriosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis31.7CCL2, APOA1, APOB, EDN1, HGF
2coronary heart disease30.3CCR5, SELE, APOA1, IL6, EDN1, APOB
3coronary artery disease,30.3IL6, EDN1, SELE, APOB, APOA1, CCL2
4atherosclerosis30.3SELE, IL6, CXCL12, EDN1, APOB, APOE
5vasculitis30.1SELE, CCL2
6arteriosclerosis obliterans30.1HGF
7hyperhomocysteinemia30.1CCL2, APOE, SELE
8acute myocardial infarction30.1SELE, EDN1, APOB, APOA1, CCL5
9coronary thrombosis10.3
10angina pectoris10.1
11subacute bacterial endocarditis10.1
12cerebral arteriosclerosis10.1
13craniosynostosis with radiohumeral fusions and other skeletal and craniofacial anomalies10.1
14coronary heart disease 210.1
15coronary heart disease 710.1
16coronary heart disease 910.1
17coronary heart disease 810.1
18coronary heart disease 610.1
19coronary heart disease 410.1
20craniodiaphyseal dysplasia, autosomal dominant10.1
21coronary heart disease 310.1
22malaria10.0CCL5
23sarcoma10.0VCL
24bronchiolitis10.0CCL5
25polymyalgia rheumatica10.0CCL5
26rhinitis10.0CCL5
27dermatitis10.0SELE
28stomach cancer10.0HGF
29chondrosarcoma10.0VCL
30biliary atresia10.0HGF
31atopy10.0CCL5
32thromboembolism10.0APOA1
33hepatitis b10.0APOA1
34gastric ulcer10.0HGF
35schistosomiasis10.0CCR5
36myasthenia gravis10.0CCR5
37antiphospholipid syndrome10.0SELE
38cholangiocarcinoma10.0HGF
39diabetic retinopathy10.0CXCL12
40polycystic ovary syndrome10.0APOA1
41malignant glioma10.0HGF
42herpes simplex10.0CCL5
43gastritis10.0CCL5
44glaucoma10.0EDN1
45chagas disease10.0CCR5
46guillain-barre syndrome10.0CCR5
47thrombophilia10.0SELE
48neuritis10.0CCL5
49uremia10.0TF
50severe combined immunodeficiency10.0CXCL12

Graphical network of the top 20 diseases related to Coronary Arteriosclerosis:



Diseases related to coronary arteriosclerosis

Clinical Features for Coronary Arteriosclerosis

Drugs & Therapeutics for Coronary Arteriosclerosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Coronary Arteriosclerosis

Drug clinical trials:

Search ClinicalTrials for Coronary Arteriosclerosis

Search NIH Clinical Center for Coronary Arteriosclerosis

Search CenterWatch for Coronary Arteriosclerosis

Genetic Tests for Coronary Arteriosclerosis

Anatomical Context for Coronary Arteriosclerosis

Animal Models for Coronary Arteriosclerosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Coronary Arteriosclerosis

Sources:
51PubMed
See all sources

Articles related to Coronary Arteriosclerosis:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Response letter regarding the article "significance of the presence of metabolic syndrome in patients with asymptomatic arteriosclerosis affecting the aorta and the cerebral, extra-cranial carotid and coronary arteries". (24126413)
2013
2
The influence of obesity on progression of coronary arteriosclerosis and clinical course after ST elevation acute myocardial infarction treated with primary coronary interventions. (22119914)
2011
3
Why are the intramyocardial portions of the coronary arteries spared from arteriosclerosis? Clinical implications. (22477493)
2009
4
Chronic myocardial infarction due to arteriosclerosis of coronary arteries followed by acute thromboembolism of caudal abdominal aorta in a cat. (15997196)
2005
5
Effect of tobacco smoking on endothelial function in patients with coronary arteriosclerosis]. (15088418)
2004
6
In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs. (11795302)
2001
7
Myocardial scintigraphy correlates poorly with coronary angiography in the screening of transplant arteriosclerosis. (11521129)
2001
8
Contribution of proliferating leukocytes to phenotypic change in smooth muscle cells during the development of coronary arteriosclerosis in transplanted hearts. (10720843)
2000
9
Gene therapy for heart transplantation-associated coronary arteriosclerosis. (10865827)
2000
10
Accelerated coronary atherosclerosis and arteriosclerosis in young human-immunodeficiency-virus-positive patients. (10715805)
2000
11
Internal mammary artery perfusing Leriche's syndrome in association with significant coronary arteriosclerosis: four case reports and review of literature. (10751774)
2000
12
Insulin-like growth factor-binding protein-3 is associated with the presence and extent of coronary arteriosclerosis (10764692)
2000
13
Chlamydia pneumoniae infection is frequent but not associated with coronary arteriosclerosis in cardiac transplant recipients. (9874051)
1998
14
Inhibitory effect of Multiglycosidorum tripterygii on coronary arteriosclerosis after heart transplantation. (9645800)
1998
15
Failure to confirm ferritin and caeruloplasmin as risk factors for the angiographic extent of coronary arteriosclerosis. (9647413)
1998
16
Inducible nitric oxide synthase expression in coronary arteries of transplanted human hearts with accelerated graft arteriosclerosis. (9327724)
1997
17
Graft coronary arteriosclerosis in rat heart transplant model with FK 506 short-term administration. (7533425)
1995
18
Expression of meta-vinculin in human coronary arteriosclerosis is related to the histological grade of plaque formation. (7840806)
1994
19
Comparison of dietary casein and soybean protein effects on plasma lipid and gastrin levels, hepatic delta 6-desaturase activity and coronary arteriosclerosis in male Sprague-Dawley rats. A 9-month study. (8109889)
1993
20
Lipid peroxides and antioxidant defenses in accelerated transplantation-associated coronary arteriosclerosis. (8465769)
1993
21
Immunopathology of coronary arteriosclerosis in transplanted hearts. (1622999)
1992
22
Biochemical indicators of coronary arteriosclerosis]. (1800821)
1991
23
Accelerated posttransplant coronary arteriosclerosis in combined heart-lung transplantation. (1989196)
1991
24
Coronary arteriosclerosis in pediatric heart transplant survivors: limitation of long-term survival. (2299487)
1990
25
Relationship of plasma levels of estradiol to the severity of coronary arteriosclerosis. (3689480)
1987
26
Radiation-induced accelerated coronary arteriosclerosis. (3728547)
1986
27
Coronary arteriosclerosis and atherosclerosis in fast neutron or photon irradiated dogs. (7298403)
1981
28
Arterialization of the coronary veins in diffuse coronary arteriosclerosis. (404)
1975
29
The evolution of the surgical treatment of coronary arteriosclerosis]. (4567456)
1972
30
Muscular cushions of intramyocardial arteries: their relationship to coronary arteriosclerosis. (5089889)
1971
31
Reserpine inhibition of coronary arteriosclerosis. (5761839)
1969
32
Problems in the quantitation of coronary arteriosclerosis. (5913008)
1966
33
SIGNIFICANCE OF CORONARY ARTERIOSCLEROSIS IN THE INTRAMUSCULAR CORONARY ARTERIES. (14261244)
1965
34
SPONTANEOUS CORONARY ARTERIOSCLEROSIS IN REPEATEDLY BRED MALE AND FEMALE RATS. (14104162)
1964
35
DIFFUSE CORONARY ARTERIOSCLEROSIS VERSUS ISOLATED PLAQUES IN THE ETIOLOGY OF MYOCARDIAL INFARCTION. (14176894)
1964
36
A PERSPECTIVE OF BIOLOGICAL AND OTHER FACTORS CONTRIBUTING TO CORONARY ARTERIOSCLEROSIS. (14181736)
1964
37
Experimental production of coronary arteriosclerosis in normotensive animals. (13916933)
1962
38
Clinical treatment of circumscribed coronary occlusion & therapy of coronary sclerosis with the inclusion of adjuvant surgery. II. Therapy & prophylaxis of coronary arteriosclerosis]. (13551802)
1958
39
Clinical aspects of coronary arteriosclerosis. (13418385)
1957
40
Coronary (ischaemic) heart disease in patients with arteriosclerosis obliterans. (13394194)
1956
41
Effect of estrogenic hormone on serum lipids in patients with coronary arteriosclerosis. (14364754)
1955
42
The increasing incidence of coronary arteriosclerosis in diabetes mellitus; preliminary manuscript. (13011668)
1953
43
Histogenesis of coronary arteriosclerosis. (12979061)
1952
44
Coronary arteriosclerosis in diabetics. (14902743)
1952
45
Coronary arteriosclerosis. (14793683)
1951
46
WEEKLY clinicopathological exercises: healed subacute bacterial endocarditis, mitral valve; rheumatic endocarditis, aortic valve, chronic; coronary arteriosclerosis, marked; myocardial infarction, left ventricle, recent massive. (14785792)
1951
47
Coronary arteriosclerosis, with thrombosis. (18886968)
1948
48
Significance of cholesterol in coronary arteriosclerosis. (18876023)
1948
49
Coronaries; coronary arteriosclerosis with special reference to its etiology and pathogenesis; experimental studies. (20267062)
1947
50
Coronaries; coronary arteriosclerosis with special reference to its etiology and pathogenesis (histo-pathological studies). (20251825)
1947

Genetic Variations for Coronary Arteriosclerosis

Expression for genes affiliated with Coronary Arteriosclerosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Coronary Arteriosclerosis

Search GEO for disease gene expression data for Coronary Arteriosclerosis.

Pathways for genes affiliated with Coronary Arteriosclerosis

Sources:
38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Coronary Arteriosclerosis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL5, HGF
29.5APOB, APOA1
3
Hide members
9.5CCR5, CXCL12, HGF
4
Hide members
9.4CCL2, VCL, SELE
59.3SELE, IL6, APOA1
6
Hide members
9.2VCL, CXCL12, CCR5, HGF
79.2CXCL12, TF, EDN1
8
Hide members
9.2CCL2, IL6, CCL5
9
Hide members
9.1HGF, APOA1, TF, VCL
109.1IL6, EDN1, TF
119.0CCL5, CCR5, CCL2, CXCL12
12
Hide members
9.0CCL5, CXCL12, CCL2, CCR5
13
Hide members
9.0CXCL12, CCR5, CCL5, HGF, VCL
14
Hide members
8.8CCL5, IL6, CCL2, CCR5
15
Hide members
8.8APOB, TF, APOA1, HGF
16
Hide members
8.7CXCL12, CCL2, CCR5, CCL5, VCL
17
Hide members
8.7APOA1, APOB, APOE
18
Hide members
8.7APOB, APOE, APOA1
19
Hide members
8.7APOE, APOB, APOA1
208.7APOE, APOB, APOA1
21
Hide members
8.7APOB, APOE, APOA1
22
Hide members
8.6CCL5, CCL2, CCR5, CXCL12, EDN1
23
Hide members
8.5HGF, CXCL12, IL6, CCL2, CCL5
248.5IL6, CCL2, APOB, APOA1
258.5IL6, CCL5, SELE, EDN1, CCL2
26
Hide members
8.2HGF, IL6, CXCL12, CCL2, CCR5, CCL5
27
Hide members
6.8APOA1, CXCL12, APOB, CCL2, CCR5, CCL5

Compounds for genes affiliated with Coronary Arteriosclerosis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Coronary Arteriosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.3HGF, CXCL12
2herbimycin a45 6010.9HGF, CXCL12, SELE
3palmitate459.8SELE, CCR5, TF
4cyclosporin a45 29 6011.6CCL5, TF, EDN1
5vitamin a45 11 2411.4APOB, APOA1, HGF
6glutamate459.4APOB, APOA1
7sdf 1459.4CCR5, CCL2, CXCL12, CCL5
8heparin45 29 11 2412.3VCL, SELE, CCL5, CCR5, CXCL12
9dexamethasone45 50 29 1112.3HGF, CCL5, CXCL12, IL6
10rantes459.3CXCL12, IL6
11mdms459.2CCL5, CCR5, CXCL12, CCL2
12larc459.2CXCL12, CCL5, CCR5, CCL2
13serine459.1CCL2, CCL5, CCR5, SELE, VCL
14mip 1alpha459.1CCL2, CCL5, CCR5, IL6
15ccl445 2910.0CXCL12, CCL2, CCR5, CCL5, HGF
16dextran sulfate458.8IL6, APOB, APOA1, CCR5, HGF
17ccl345 299.8CCL5, CCR5, CCL2, CXCL12, IL6
18losartan45 50 29 1111.7HGF, APOE, EDN1, SELE
19pdtc458.7CCL5, IL6, CCL2, HGF, SELE
20tibolone458.7SELE, CCL2, APOA1, APOB
218-isoprostane458.6IL6, EDN1, CCL2, TF, SELE
22groalpha458.6CXCL12, IL6, CCL2, SELE, CCL5, CCR5
23cytochalasin d45 609.4SELE, TF, CCL2, CCR5, CCL5, VCL
24polysaccharide458.4SELE, CCR5, CCL2, APOB, CXCL12, HGF
25creatinine458.4SELE, TF, APOB, APOE, APOA1
26fenofibrate45 50 1110.3SELE, IL6, APOB, CCL2, CCL5, APOA1
27sb 20358045 609.2SELE, CXCL12, EDN1, CCL2, CCL5, HGF
28folate458.0APOB, APOE, SELE, CCL5, HGF, TF
29vitamin b12458.0APOE, APOA1, CCL2, TF, APOB
30aspirin45 50 29 2411.0CCL5, SELE, APOA1, APOE, APOB, HGF
31homocysteine45 249.0CCL5, SELE, APOA1, APOB, CCL2, APOE
32epinephrine45 11 249.9CCL5, SELE, IL6, APOB, TF, EDN1
33probucol45 118.9APOE, APOB, EDN1, SELE, APOA1, CCL2
34histamine45 29 249.8HGF, SELE, IL6, EDN1, CCL2, CCR5
35fluvastatin45 50 29 1110.8SELE, IL6, APOB, APOE, APOA1, CCL2
36prostacyclin457.7TF, APOE, APOA1, CCL2, HGF, SELE
37pravastatin45 50 29 11 2411.7APOA1, CCL2, APOE, APOB, IL6, SELE
38lactate457.7APOA1, SELE, IL6, TF, CCL5, HGF
39n acetylcysteine457.7SELE, CCL5, CCL2, APOE, TF, IL6
40fibrinogen457.5VCL, IL6, CXCL12, APOB, TF, CCL2
41glutamine457.4HGF, CCR5, CCL2, APOB, APOE, TF
42atorvastatin45 50 29 11 2411.4APOB, EDN1, IL6, SELE, APOE, APOA1
43actinomycin d457.3HGF, CCR5, CCL2, APOE, EDN1, CXCL12
44genistein45 29 60 2 11 2412.3CCL5, HGF, APOA1, APOB, EDN1, CXCL12
45simvastatin45 50 60 29 11 2412.2CCL5, CCR5, SELE, IL6, APOB, APOE
46testosterone45 60 11 2410.1APOA1, VCL, IL6, APOB, APOE, SELE
47alanine456.9APOA1, IL6, TF, APOB, APOE, CCR5
48lipid456.6IL6, CXCL12, APOB, APOE, APOA1, CCL2
49cholesterol45 29 11 249.4CXCL12, TF, APOA1, CCL2, CCR5, IL6
50vegf456.1CCL5, IL6, CXCL12, EDN1, TF, APOB

GO Terms for genes affiliated with Coronary Arteriosclerosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Coronary Arteriosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.6APOA1, TF
2high-density lipoprotein particleGO:0343649.3APOE, APOA1
3intermediate-density lipoprotein particleGO:0343639.1APOB, APOE
4chylomicronGO:0426279.0APOE, APOB
5endocytic vesicle lumenGO:0716828.9APOA1, APOE, APOB
6very-low-density lipoprotein particleGO:0343618.8APOB, APOE, APOA1
7low-density lipoprotein particleGO:0343628.7APOB, APOE
8early endosomeGO:0057698.3APOA1, APOE, APOB, TF
9extracellular spaceGO:0056156.2SELE, HGF, CCL5, CCL2, APOA1, APOE
10extracellular regionGO:0055765.8HGF, CCL5, CCL2, APOA1, APOE, APOB

Biological processes related to Coronary Arteriosclerosis according to GeneCards/GeneDecks:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of monocyte chemotaxisGO:09002610.1CXCL12, CCL5
2positive regulation of macrophage chemotaxisGO:01075910.0CCL5, CCL2
3macrophage chemotaxisGO:0482469.9CCL5, CCL2
4dendritic cell chemotaxisGO:0024079.9CCL5, CCR5
5maternal process involved in parturitionGO:0601379.9CCL2, EDN1
6positive regulation of JAK-STAT cascadeGO:0464279.9CCL5, IL6
7calcium-mediated signalingGO:0197229.8CCR5, EDN1, SELE
8negative regulation of hormone secretionGO:0468889.8IL6, EDN1
9regulation of vascular endothelial growth factor productionGO:0105749.8CCL2, IL6
10organ regenerationGO:0311009.7HGF, CCL2, APOA1
11MAPK cascadeGO:0001659.7CCL5, CCR5, CCL2
12regulation of Cdc42 protein signal transductionGO:0324899.7APOA1, APOE
13positive regulation of smooth muscle cell proliferationGO:0486619.7IL6, EDN1, CCL5
14peripheral nervous system axon regenerationGO:0140129.7APOE, APOA1
15high-density lipoprotein particle assemblyGO:0343809.7APOE, APOA1
16positive regulation of cell migrationGO:0303359.7EDN1, CCL5, HGF
17high-density lipoprotein particle clearanceGO:0343849.6APOA1, APOE
18positive regulation of cholesterol esterificationGO:0108739.6APOA1, APOE
19phospholipid effluxGO:0337009.6APOE, APOA1
20monocyte chemotaxisGO:0025489.6IL6, CCL2, CCL5
21cholesterol transportGO:0303019.6APOA1, APOB
22platelet degranulationGO:0025769.6HGF, APOA1, TF, VCL
23response to virusGO:0096159.5CXCL12, APOB, CCL5
24chemokine-mediated signaling pathwayGO:0700989.4CXCL12, CCL2, CCR5, CCL5
25response to amino acid stimulusGO:0432009.4IL6, EDN1, CCL2
26lipoprotein catabolic processGO:0421599.4APOE, APOB
27negative regulation of blood coagulationGO:0301959.4APOE, EDN1
28high-density lipoprotein particle remodelingGO:0343759.4APOA1, APOE
29chemotaxisGO:0069359.4CCL5, CCR5, CCL2, CXCL12
30retinoid metabolic processGO:0015239.4APOE, APOB
31cellular response to fibroblast growth factor stimulusGO:0443449.4CCL5, CCL2
32low-density lipoprotein particle remodelingGO:0343749.3APOE, APOB
33cell surface receptor signaling pathwayGO:0071669.2EDN1, CCL2, CCR5
34reverse cholesterol transportGO:0436919.2APOE, APOA1
35lipoprotein biosynthetic processGO:0421589.1APOA1, APOE, APOB
36cholesterol effluxGO:0333449.1APOB, APOE, APOA1
37cellular response to tumor necrosis factorGO:0713569.1CCL5, CCL2, APOB, EDN1
38lipoprotein metabolic processGO:0421579.1APOA1, APOE, APOB
39cholesterol homeostasisGO:0426329.1APOA1, APOE, APOB
40platelet activationGO:0301689.1HGF, APOA1, TF, IL6, VCL
41response to lipopolysaccharideGO:0324969.0APOB, EDN1, IL6, SELE
42cholesterol metabolic processGO:0082039.0APOB, APOE, APOA1
43phototransduction, visible lightGO:0076039.0APOB, APOE, APOA1
44inflammatory responseGO:0069549.0CCL5, CCR5, CCL2, IL6, SELE
45cellular calcium ion homeostasisGO:0068748.9CCL5, CCL2, APOE, CXCL12
46agingGO:0075688.9CCL2, APOE, IL6
47cellular response to interleukin-1GO:0713478.9EDN1, APOE, CCL2, CCL5
48blood coagulationGO:0075968.6HGF, APOA1, APOB, TF, VCL, SELE
49G-protein coupled receptor signaling pathwayGO:0071868.1CXCL12, EDN1, APOE, APOA1, CCL2, CCR5

Molecular functions related to Coronary Arteriosclerosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.9CCL5, HGF
2chemokine activityGO:0080099.4CXCL12, CCL2, CCL5
3phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.4APOA1, APOE
4low-density lipoprotein particle receptor bindingGO:0507508.9APOE, APOB
5cholesterol transporter activityGO:0171278.8APOB, APOE, APOA1
6heparin bindingGO:0082018.2APOB, APOE, CCL2
7protein bindingGO:0055156.4HGF, CCL5, CCR5, APOA1, APOE, APOB

Products for genes affiliated with Coronary Arteriosclerosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coronary Arteriosclerosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet