MCID: CRN074
MIFTS: 45

Coronary Artery Aneurysm malady

Cardiovascular category

Summaries for Coronary Artery Aneurysm

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Coronary artery aneurysm is an abnormal dilatation of part of the coronary artery. more...

MalaCards: Coronary Artery Aneurysm is related to kawasaki disease and coronary heart disease. An important gene associated with Coronary Artery Aneurysm is ITPKC (inositol-trisphosphate 3-kinase C), and among its related pathways are Rheumatoid arthritis and Apoptosis and survival Caspase cascade. The compounds endotoxin and tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include lymph node, whole blood and heart, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Coronary Artery Aneurysm

Sources:
43NIH Rare Diseases, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

coronary artery aneurysm 43


External Ids:

ICD1025 I25.4

Related Diseases for Coronary Artery Aneurysm

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Coronary Artery Aneurysm family:

congenital coronary artery aneurysm

Diseases related to Coronary Artery Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1kawasaki disease31.6CCL2, TIMP1, ITPKC
2coronary heart disease30.5VCAM1
3atherosclerosis30.4CCL2, VCAM1, TIMP1, GZMB, TNF
4systemic lupus erythematosus30.4HLA-DRB1, HLA-DPB1, HLA-A, CCL2, TNF, VCAM1
5mixed connective tissue disease30.2HLA-A
6vascular disease30.2TNF, HLA-C, TIMP1
7arthritis30.2HLA-A, HLA-DRB1, HLA-B, HLA-C, GZMB, CCL2
8coronary aneurysm11.5
9coronary artery disease,11.1
10aneurysm disease11.1
11congenital coronary artery aneurysm10.8
12acute myocardial infarction10.7
13aortic aneurysm10.6
14coronary thrombosis10.6
15heart aneurysm10.6
16cardiac tamponade10.5
17neurofibromatosis10.4
18cardiac rupture10.4
19marfan syndrome10.3
20coronary artery vasospasm10.3
21coronary restenosis10.3
22n syndrome10.3
23patent ductus arteriosus10.3
24aortic disease10.3
25mitral valve prolapse10.1
26pyuria10.1
27wolff-parkinson-white syndrome10.1
28supravalvular aortic stenosis10.1
29aortitis10.1
30polyarteritis nodosa10.1
31splenic infarction10.1
32abdominal aortic aneurysm10.1
33myocardial stunning10.1
34cocaine abuse10.1
35aortic valve prolapse10.1
36anteroseptal myocardial infarction10.1
37splenic artery aneurysm10.1
38osteogenesis imperfecta10.1
39hemopericardium10.1
40splenic disease10.1
41chronic active epstein-barr virus infection10.1
42hypereosinophilic syndrome10.1
43superior vena cava syndrome10.1
44image syndrome10.1
45cerebral aneurysms10.1
46congenital patent ductus arteriosus aneurysm10.1
47myocarditis10.0PRF1
48toxic epidermal necrolysis10.0GZMB
49sjogren's syndrome10.0GZMB
50alopecia areata10.0GZMB

Graphical network of the top 20 diseases related to Coronary Artery Aneurysm:



Diseases related to coronary artery aneurysm

Clinical Features for Coronary Artery Aneurysm

Drugs & Therapeutics for Coronary Artery Aneurysm

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Coronary Artery Aneurysm

Drug clinical trials:

Search ClinicalTrials for Coronary Artery Aneurysm

Search NIH Clinical Center for Coronary Artery Aneurysm

Search CenterWatch for Coronary Artery Aneurysm

Genetic Tests for Coronary Artery Aneurysm

Anatomical Context for Coronary Artery Aneurysm

Sources:
33MalaCards
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MalaCards organs/tissues related to Coronary Artery Aneurysm:

33
Lymph node, Whole blood, Heart, Prostate, T cells, B cells, Endothelial, Trachea

Animal Models for Coronary Artery Aneurysm or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Coronary Artery Aneurysm:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.6CCL2, GZMB, TNF, HLA-E, ITPR3, PRF1
2MP:00053878.5VCAM1, TIMP1, CCL2, GZMB, TNF, HLA-B
3MP:00053978.5TIMP1, CCL2, GZMB, TNF, HLA-B, ITPKC

Publications for Coronary Artery Aneurysm

Sources:
51PubMed
See all sources

Articles related to Coronary Artery Aneurysm:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Mycotic left main coronary artery aneurysm following double-valve replacement for active infective endocarditis. (22673548)
2013
2
Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis. (23677057)
2013
3
Combined Coronary Artery Bypass Grafting and Open Abdominal Aortic Aneurysm Repair Is a Reasonable Treatment Approach: A Systematic Review. (24078517)
2013
4
An apparent case of undiagnosed donor Kawasaki disease manifesting as coronary artery aneurysm in a pediatric heart transplant recipient. (23134325)
2013
5
Very Late Development of Coronary Artery Aneurysm with Total Occlusion following Sirolimus-Eluting Stent Implantation. (24293982)
2012
6
Typical coronary artery aneurysm exactly within drug-eluting stent implantation region in a patient with rheumatoid arthritis. (23233781)
2012
7
Cardiac computed tomography as a diagnostic tool for coronary artery aneurysm following percutaneous coronary intervention. (22508210)
2012
8
Surgical management of left main coronary artery aneurysm. (22897376)
2012
9
An unusual case of left main coronary artery aneurysm with right ventricle fistula. (22529606)
2012
10
Acute myocardial infarction in a patient with coronary artery aneurysm and Crohn's disease. (22995613)
2012
11
Coronary aneurysm with double right coronary artery and fistula. (21241866)
2011
12
Successful correction of congenital giant right coronary artery aneurysm with fistula to left ventricle. (21220413)
2011
13
Association of sterile pyuria and coronary artery aneurysm in Kawasaki syndrome. (22052144)
2011
14
Detection of a large left anterior descending coronary artery aneurysm using low-dose coronary multidetector computed tomography. (20093946)
2011
15
Segmented coronary artery aneurysms and kawasaki disease. (23074612)
2011
16
Case images: giant coronary aneurysm accompanied by a coronary artery fistula. (20935441)
2010
17
Significant coronary artery disease associated with coronary artery aneurysm and elevation of prostate-specific antigen during acute myocardial infarction. (19138808)
2010
18
Giant right coronary artery aneurysm mimicking pericardial mass. (20705225)
2010
19
Resection and patch repair of a large saccular coronary artery aneurysm at the left main bifurcation. (19101318)
2009
20
Usefulness of 64-slice MDCT for follow-up of young children with coronary artery aneurysm due to Kawasaki disease: initial experience. (18164157)
2009
21
Neutropenia in the acute phase of Kawasaki disease and prevention of coronary artery aneurysm. (19674356)
2009
22
Surgical treatment of left main coronary artery aneurysm: a case report. (19075521)
2009
23
Detectable silent calcification in a regressed coronary artery aneurysm of a young adult with a history of Kawasaki disease. (17828569)
2008
24
Giant coronary artery aneurysm: an unusual cause of a mediastinal mass (2008: 9b). (19002468)
2008
25
Assessment of coronary artery aneurysm after stent placement for myocardial infarction: evaluation by multidetector computed tomography. (19083932)
2008
26
Giant Kawasaki coronary artery aneurysm: cardiac imaging evolution. (18606613)
2008
27
Giant left main coronary artery aneurysm. (17622400)
2007
28
Unruptured left main coronary artery aneurysm presented with acute cerebral infarction. (17307764)
2007
29
Giant coronary artery aneurysm in Behcet's disease. (17933996)
2007
30
Hyperimmunoglobulinemia E syndrome associated with coronary artery aneurysms: deficiency of central memory CD4+ T cells and expansion of effector memory CD4+ T cells. (17458437)
2007
31
Rapidly expanding right coronary artery aneurysm. (16733178)
2006
32
Surgical treatment of giant coronary artery aneurysm. (16153934)
2005
33
Effect of initial corticosteroid therapy on coronary artery aneurysm formation in Kawasaki disease: a meta-analysis of 862 children. (16199713)
2005
34
Giant left main coronary artery aneurysm: an unusual cause of acute myocardial infarction. (12512756)
2002
35
Coronary artery aneurysm after stent implantation: acute and long-term results after percutaneous treatment with a stent graft. (11974666)
2002
36
Unusual coronary artery aneurysm and acute myocardial infarction in a middle-aged man with systemic lupus erythematosus. (11570783)
2001
37
Three-dimensional densimetric analysis of coronary artery aneurysm. (10831534)
2000
38
Neurofibromatosis associated with a coronary artery aneurysm. (11144803)
2000
39
Coronary artery aneurysm after stent implantation. (10481393)
1999
40
Repair of a coronary artery aneurysm by implantation of a coronary stent. (9699939)
1998
41
Coronary artery aneurysm: a review. (9247557)
1997
42
Frequency and outcome of development of coronary artery aneurysm after intracoronary stent placement and angioplasty. STRESS Trial Investigators. (9114773)
1997
43
Giant right coronary artery aneurysm with fistulous connection to the coronary sinus: diagnosis and management. (8903543)
1996
44
Transcatheter embolization in treatment of congenital coronary artery aneurysm. (8579039)
1996
45
Coronary artery aneurysm formation following directional coronary atherectomy. (1446330)
1992
46
Vasospasm in a coronary artery aneurysm. (1901244)
1991
47
Coronary artery aneurysm without stenosis in association with Osler-Weber-Rendu disease--a case report. (1992858)
1991
48
Ruptured aneurysm of sinus of Valsalva co-existing with a single coronary artery. (2924786)
1989
49
Congenital aneurysm of the left ventricle associated with supravalvular aortic stenosis and aneurysm of the left main coronary artery: case report and review of the literature. (1115410)
1975
50
Coronary artery aneurysm. (13700684)
1960

Genetic Variations for Coronary Artery Aneurysm

Expression for genes affiliated with Coronary Artery Aneurysm

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Coronary Artery Aneurysm

Search GEO for disease gene expression data for Coronary Artery Aneurysm.

Pathways for genes affiliated with Coronary Artery Aneurysm

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 54Reactome, 56SinoBiological, 53R&D Systems
See all sources

Pathways related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HLA-DPB1
2
Apoptosis and survival Caspase cascade
Hide members
10.0PRF1, TNF, GZMB
39.9C2, HLA-DRB1, HLA-DPB1
4
Hide members
9.9PRF1, HLA-A, HLA-DRB1
5
Hide members
9.9GZMB, HLA-DRB1, HLA-A
69.9CCL2, TNF, VCAM1
79.8HLA-A, HLA-B, HLA-C
8
Hide members
9.8HLA-DRB1, HLA-DPB1, HLA-DQB2
9
Hide members
9.8HLA-DRB1, HLA-DPB1, HLA-DQB2
10
Hide members
9.8HLA-DQB2, HLA-DPB1, HLA-DRB1
11
Immune response Antigen presentation by MHC class II
Hide members
9.8HLA-DRB1, HLA-DPB1, HLA-DQB2
129.8HLA-DQB2, HLA-DPB1, HLA-DRB1
139.8GZMB, TNF, HLA-A, PRF1
149.7HLA-C, HLA-B, HLA-DPB1, HLA-E
15
Hide members
9.7C2, HLA-DRB1, HLA-DPB1, TNF
169.7HLA-C, HLA-B, HLA-E, HLA-A
17
Hide members
9.7HLA-C, HLA-B, HLA-E, HLA-A
18
Immune response IFN alpha/beta signaling pathway
Hide members
9.7HLA-C, HLA-B, HLA-E, HLA-A
199.7HLA-C, HLA-B, HLA-E, HLA-A
209.7HLA-C, HLA-B, HLA-E, HLA-A
21
Hide members
9.7HLA-A, HLA-E, HLA-B, HLA-C
229.6HLA-DQB2, HLA-DPB1, HLA-DRB1, ITPR3
239.6HLA-DQB2, HLA-DPB1, HLA-DRB1, ITPR3
24
Immune response ICOS pathway in T-helper cell
Hide members
9.6HLA-DQB2, HLA-DPB1, HLA-DRB1, ITPR3
25
Hide members
9.5HLA-A, HLA-E, HLA-DPB1, HLA-C, TNF
26
Hide members
9.5HLA-C, HLA-B, HLA-DRB1, HLA-E, HLA-A
27
Immune response NFAT in immune response
Hide members
9.4HLA-DQB2, HLA-DPB1, HLA-DRB1, ITPR3, IGHE
28
Hide members
9.3GZMB, TNF, HLA-C, HLA-B, HLA-E, HLA-A
299.3HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E, HLA-A
309.3HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E, HLA-A
31
Hide members
9.2HLA-C, HLA-B, HLA-E, HLA-A, ITPR3, IGHE
329.1HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E, HLA-A
33
Hide members
8.9CCL2, TNF, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1
34
Hide members
8.8HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E
35
Hide members
8.8PRF1, GZMB, TNF, HLA-C, HLA-B, HLA-DPB1
36
Hide members
8.7GZMB, TNF, HLA-C, HLA-B, HLA-E, HLA-A
37
Hide members
8.4HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E

Compounds for genes affiliated with Coronary Artery Aneurysm

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.6VCAM1
2tacrolimus45 50 1112.6GZMB, TIMP1
3dr-104510.5HLA-A, HLA-DRB1
4dpa 14510.4HLA-DPB1, HLA-DRB1
5chromium4510.4PRF1, GZMB, TIMP1
6listeriolysin4510.4HLA-B, PRF1
7ro 31-75494510.3TNF, VCAM1
8magnolol4510.3VCAM1, CCL2
9rantes4510.3HLA-B, TNF, GZMB
10dexamethasone45 50 29 1113.3IGHE, GZMB, TIMP1
11polymyxin b4510.3VCAM1, TNF, CCL2
12groalpha4510.3CCL2, TNF, VCAM1
13parthenolide45 211.3CCL2, TNF, VCAM1
148-isoprostane4510.2CCL2, TNF, VCAM1
15lipoteichoic acid4510.2HLA-B, TNF, CCL2
16alpha lipoic acid4510.2CCL2, TNF, VCAM1
17polyinosinic-polycytidylic acid4510.2VCAM1, HLA-B, TNF
18budesonide45 50 1112.2TNF, IGHE, VCAM1
19fluticasone propionate45 50 60 1113.1TNF, IGHE, VCAM1
20carbamazepine45 50 1112.1TNF, HLA-B, PRRC2A, BAG6
21pioglitazone45 50 29 1113.1TIMP1, CCL2, TNF, VCAM1
22diphenyleneiodonium4510.1CCL2, TNF, VCAM1
23atorvastatin45 50 29 11 2414.1TIMP1, CCL2, TNF, VCAM1
24rosiglitazone45 50 29 11 2414.1TIMP1, CCL2, TNF, VCAM1
25tgf beta14510.1TIMP1, CCL2, TNF, VCAM1
26prednisolone45 29 1112.0VCAM1, IGHE, TNF, GZMB
27herbimycin a45 6011.0VCAM1, TNF, CCL2, TIMP1
28l-nmma4510.0TNF, IGHE, VCAM1
29fenofibrate45 50 1112.0CCL2, TNF, VCAM1
30infliximab45 50 1112.0TIMP1, TNF, IGHE
31curcumin4510.0TIMP1, CCL2, TNF, VCAM1
32prostacyclin4510.0TIMP1, CCL2, TNF, VCAM1
33tarc4510.0CCL2, TNF, IGHE
34ly294002459.9VCAM1, TNF, GZMB, CCL2, TIMP1
35paraffin459.9TIMP1, CCL2, GZMB, HLA-B, VCAM1
36ivig459.9IGHE, TNF, GZMB
37aspartate459.9CCL2, HLA-B, ITPR3, IGHE, VCAM1
3815-deoxy-delta-12,14-prostaglandin j2459.9VCAM1, TNF, CCL2
39n acetylcysteine459.8TIMP1, CCL2, TNF, IGHE, VCAM1
40histamine45 29 2411.8TIMP1, CCL2, TNF, IGHE, VCAM1
41superoxide45 2410.7CCL2, GZMB, TNF, PRF1, VCAM1
42serine459.7TIMP1, CCL2, GZMB, TNF, HLA-B, C2
43lactate459.6TIMP1, GZMB, TNF, HLA-B, IGHE, VCAM1
44cyclosporin a45 29 6011.6TIMP1, GZMB, TNF, HLA-B, HLA-A, IGHE
45methotrexate45 50 1111.5TIMP1, TNF, HLA-DRB1, IGHE
46vegf459.5TIMP1, CCL2, GZMB, TNF, IGHE, VCAM1
47heparin45 29 11 2412.5TIMP1, GZMB, ITPR3, VCAM1
48nitric oxide45 11 2411.4TIMP1, CCL2, GZMB, TNF, HLA-B, VCAM1
49arginine459.3TIMP1, CCL2, GZMB, HLA-B, HLA-DRB1, HLA-A
50alanine459.2TIMP1, GZMB, HLA-DRB1, HLA-A, IGHE, VCAM1

GO Terms for genes affiliated with Coronary Artery Aneurysm

Sources:
16Gene Ontology
See all sources

Cellular components related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.0HLA-DRB1, HLA-DPB1, HLA-DQB2
2clathrin-coated endocytic vesicle membraneGO:0306699.9HLA-DRB1, HLA-DPB1, HLA-DQB2
3MHC class I protein complexGO:0426129.9HLA-C, HLA-B, HLA-E, HLA-A
4phagocytic vesicle membraneGO:0306709.9HLA-C, HLA-B, HLA-E, HLA-A
5transport vesicle membraneGO:0306589.9HLA-DRB1, HLA-DPB1, HLA-DQB2
6early endosome membraneGO:0319019.8HLA-C, HLA-B, HLA-E, HLA-A
7trans-Golgi network membraneGO:0325889.8HLA-DQB2, HLA-DPB1, HLA-DRB1
8endocytic vesicle membraneGO:0306669.5HLA-DQB2, HLA-DPB1, HLA-DRB1
9integral to lumenal side of endoplasmic reticulum membraneGO:0715569.3HLA-A, HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1
10ER to Golgi transport vesicle membraneGO:0125079.3HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E
11Golgi membraneGO:0001399.2HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E
12extracellular regionGO:0055769.1C2, IGHE, PRF1, HLA-C, TNF, CCL2
13plasma membraneGO:0058868.2TNF, HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1

Biological processes related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.1TNF, VCAM1
2detection of bacteriumGO:01604510.1HLA-A, HLA-DRB1, HLA-B
3positive regulation of synaptic transmissionGO:05080610.0CCL2, TNF
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.0HLA-C, HLA-B, HLA-E, HLA-A
5positive regulation of T cell mediated cytotoxicityGO:00191610.0HLA-A, HLA-E, HLA-B, HLA-C
6type I interferon-mediated signaling pathwayGO:0603379.9HLA-C, HLA-B, HLA-E, HLA-A
7T cell costimulationGO:0312959.9HLA-DRB1, HLA-DPB1, HLA-DQB2
8agingGO:0075689.9VCAM1, CCL2, TIMP1
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.9HLA-C, HLA-B, HLA-E, HLA-A
10antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.9HLA-C, HLA-B, HLA-E, HLA-A
11antigen processing and presentation of peptide antigen via MHC class IGO:0024749.9HLA-A, HLA-E, HLA-B, HLA-C
12regulation of immune responseGO:0507769.8HLA-C, HLA-B, HLA-E, HLA-A, VCAM1
13T cell receptor signaling pathwayGO:0508529.7HLA-DRB1, HLA-DPB1, HLA-DQB2
14antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.5HLA-DQB2, HLA-DPB1, HLA-DRB1
15innate immune responseGO:0450879.4HLA-C, HLA-B, HLA-E, ITPR3, IGHE, C2
16immune responseGO:0069559.3HLA-DQB2, HLA-C, HLA-B, HLA-DRB1, HLA-A, IGHE
17interferon-gamma-mediated signaling pathwayGO:0603339.2VCAM1, HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1
18cytokine-mediated signaling pathwayGO:0192219.0CCL2, HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1

Molecular functions related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.0HLA-DRB1, HLA-DQB2
2peptide antigen bindingGO:0426059.4HLA-A, HLA-E, HLA-DRB1, HLA-B, HLA-C
3receptor bindingGO:0051029.2CCL2, HLA-C, HLA-B, HLA-E, HLA-A

Products for genes affiliated with Coronary Artery Aneurysm

  • Antibodies
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  • Lysates
  • Antibodies

Sources for Coronary Artery Aneurysm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet