MCID: CRN074
MIFTS: 47

Coronary Artery Aneurysm

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Coronary Artery Aneurysm

MalaCards integrated aliases for Coronary Artery Aneurysm:

Name: Coronary Artery Aneurysm 49
Coronary Artery Aneurysms 51
Coronary Aneurysm 69

Classifications:



External Ids:

ICD10 32 I25.4

Summaries for Coronary Artery Aneurysm

MalaCards based summary : Coronary Artery Aneurysm, also known as coronary artery aneurysms, is related to myocardial infarction and arteries, anomalies of. An important gene associated with Coronary Artery Aneurysm is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and t cells, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 72 Coronary artery aneurysm is an abnormal dilatation of part of the coronary... more...

Related Diseases for Coronary Artery Aneurysm

Diseases in the Coronary Artery Aneurysm family:

Congenital Coronary Artery Aneurysm

Diseases related to Coronary Artery Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 30.0 ADIPOQ CCL2 MMP1 MMP3 RETN
2 arteries, anomalies of 29.5 ADIPOQ CCL2 LEP VCAM1
3 arthritis 29.5 CCL2 MMP1 MMP13 MMP3
4 aortic aneurysm, familial abdominal, 1 29.4 CCL2 MMP1 MMP12 MMP13 MMP3
5 rheumatoid arthritis 29.3 CCL2 MMP1 MMP13 MMP3 VCAM1
6 congenital coronary artery aneurysm 12.3
7 kawasaki disease 11.7
8 chronic active epstein-barr virus infection 11.5
9 aneurysm 11.1
10 superior limbic keratoconjunctivitis 10.5 MMP1 MMP3
11 hypogonadism, male 10.4 KLK3 LEP
12 squamous cell carcinoma of the hypopharynx 10.4 MMP1 MMP3
13 mid-dermal elastolysis 10.4 MMP12 MMP7
14 spastic entropion 10.4 MMP1 MMP3 MMP7
15 prostate rhabdomyosarcoma 10.3 KLK3 MMP1
16 adult astrocytic tumour 10.3 MMP1 MMP3 MMP7
17 coronary artery dissection, spontaneous 10.3
18 light chain deposition disease 10.3 MMP1 MMP12 MMP7
19 varicose veins 10.3 MMP1 MMP3 MMP7
20 acute myocardial infarction 10.3
21 synovitis 10.3 MMP1 MMP13 MMP3 VCAM1
22 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.2
23 arteriovenous fistula 10.2
24 thrombosis 10.2
25 severe pre-eclampsia 10.2 ADIPOQ LEP VCAM1
26 coronary arterial fistulas 10.2
27 chondrosarcoma 10.1 MMP1 MMP13 MMP3
28 cardiac tamponade 10.1
29 internal hemorrhoid 10.1 MMP1 MMP7
30 acquired generalized lipodystrophy 10.1 ADIPOQ LEP RETN
31 obesity-hypoventilation syndrome 10.1 ADIPOQ LEP RETN
32 idiopathic recurrent pericarditis 10.1 ADIPOQ LEP RETN
33 lutheran suppressor, x-linked 10.1 ADIPOQ LEP RETN
34 nonalcoholic steatohepatitis 10.1 ADIPOQ LEP RETN
35 periodontitis 10.1 CCL2 MMP1 MMP3
36 mediastinitis 10.1
37 bulimia nervosa 2 10.0 ADIPOQ LEP RETN
38 morbid obesity 10.0 ADIPOQ LEP RETN
39 lipid metabolism disorder 10.0 ADIPOQ LEP RETN
40 bone inflammation disease 10.0 CCL2 MMP1 MMP13 MMP3
41 glucose metabolism disease 10.0 ADIPOQ LEP RETN
42 aging 10.0
43 episodic pain syndrome, familial, 1 10.0
44 endocarditis 10.0
45 gestational diabetes 10.0 ADIPOQ LEP RETN
46 multiple symmetrical lipomatosis 10.0 ADIPOQ LEP RETN VCAM1
47 autoinflammation, lipodystrophy, and dermatosis syndrome 10.0 ADIPOQ CCL2 VCAM1
48 neurofibromatosis, type iv, of riccardi 10.0
49 polyarteritis nodosa, childhood-onset 10.0
50 polyarteritis nodosa 10.0

Comorbidity relations with Coronary Artery Aneurysm via Phenotypic Disease Network (PDN):


Chronic Myocardial Ischemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Coronary Artery Aneurysm:



Diseases related to Coronary Artery Aneurysm

Symptoms & Phenotypes for Coronary Artery Aneurysm

MGI Mouse Phenotypes related to Coronary Artery Aneurysm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 LEP MMP1 MMP12 MMP13 MMP3 MMP7
2 immune system MP:0005387 9.36 ABHD16A ADIPOQ CCL17 CCL2 LEP MMP1

Drugs & Therapeutics for Coronary Artery Aneurysm

Drugs for Coronary Artery Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
2
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
3
Ticlopidine Approved Phase 4 55142-85-3 5472
4 Antirheumatic Agents Phase 4,Phase 2
5 Analgesics Phase 4
6 Fibrinolytic Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Cyclooxygenase Inhibitors Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Platelet Aggregation Inhibitors Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Purinergic P2 Receptor Antagonists Phase 4
16 Purinergic P2Y Receptor Antagonists Phase 4
17 Antipyretics Phase 4
18
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
19 Albumin-Bound Paclitaxel Phase 2, Phase 3
20 Antimitotic Agents Phase 2, Phase 3
21 Antineoplastic Agents, Phytogenic Phase 2, Phase 3
22
Infliximab Approved Phase 2 170277-31-3
23
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
24 Atorvastatin Calcium Phase 2 134523-03-8
25 Rho(D) Immune Globulin Phase 2
26 gamma-Globulins Phase 2
27 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
28 Anticholesteremic Agents Phase 2
29 Hypolipidemic Agents Phase 2
30 Immunoglobulins Phase 2
31 Immunoglobulins, Intravenous Phase 2
32 Antimetabolites Phase 2
33 Interleukin 1 Receptor Antagonist Protein Phase 2
34 Lipid Regulating Agents Phase 2
35 Antibodies Phase 2
36 Calcium, Dietary Phase 2
37 Gastrointestinal Agents Phase 2
38 Dermatologic Agents Phase 2
39 Anti-Bacterial Agents Phase 2
40 Anti-Infective Agents Phase 2
41 Antimalarials Phase 2
42 Antiprotozoal Agents Phase 2
43 Antiparasitic Agents Phase 2
44
Diltiazem Approved, Investigational 42399-41-7 39186
45
Adenosine Approved, Investigational 58-61-7 60961
46
Dobutamine Approved 34368-04-2 36811
47 calcium channel blockers
48 Vasodilator Agents
49 Antihypertensive Agents

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Trial to Assess the Efficacy of Combination Formula of Aspirin Plus Clopidogrel in Patients With Coronary Stent Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
2 Trial of Pulse Steroid Therapy in Kawasaki Disease--Pediatric Heart Network Completed NCT00132080 Phase 3 Steroids
3 Randomized Trial Evaluating Slow-Release Formulation TAXUS Paclitaxel-Eluting Coronary Stents to Treat De Novo Coronary Lesions Completed NCT00301522 Phase 2, Phase 3
4 Randomized Trial Evaluating Slow-Release Formulation TAXUS Paclitaxel-Eluting Coronary Stent in the Treatment of In-Stent Restenosis Completed NCT00287573 Phase 2, Phase 3
5 Trial of Atorvastatin on the Persistent Coronary Aneurysm in Children With Kawasaki Disease Unknown status NCT02114099 Phase 2 Atorvastatin
6 Anakinra and Kawasaki Disease Unknown status NCT02390596 Phase 2 Anakinra
7 Prevention of Coronary Aneurysms in Kawasaki Syndrome Completed NCT00000520 Phase 2 immunoglobulins, intravenous;aspirin
8 Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease Recruiting NCT01917721 Phase 2 Doxycycline;Standard care
9 Study of Efficacy and Safety of Canakinumab in Pediatric Patients With Kawasaki Disease Withdrawn NCT02980263 Phase 2 Canakinumab
10 Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries Unknown status NCT00548457
11 Coronary Artery Aneurysm Registry Completed NCT02563626
12 Effect of Diltiazem on Coronary Artery Ectasia Completed NCT02024919 intracoronary administration of diltiazem;intracoronary injection of 5 mL saline
13 Prevalence and Early Markers of Atherosclerosis in Adults With a History of Kawasaki Disease Completed NCT01440075
14 Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method (TCCT-TIMI) Recruiting NCT02818127
15 Etiology Study of Kawasaki Disease Recruiting NCT00154596
16 Evaluation of Emotional Status and Coronary Flow Characteristics by TIMI Frame Count Method Recruiting NCT02831153

Search NIH Clinical Center for Coronary Artery Aneurysm

Genetic Tests for Coronary Artery Aneurysm

Anatomical Context for Coronary Artery Aneurysm

MalaCards organs/tissues related to Coronary Artery Aneurysm:

38
Heart, Endothelial, T Cells, Lymph Node, Prostate

Publications for Coronary Artery Aneurysm

Articles related to Coronary Artery Aneurysm:

(show top 50) (show all 598)
# Title Authors Year
1
Thrombotic Occlusion and Revascularization of a Left Main Coronary Artery Aneurysm Years After Surgical Closure of LeftA Coronary-to-Right Ventricle Fistula. ( 29361450 )
2018
2
Surgery of giant right coronary artery aneurysm complicated with coronary artery fistula to left ventricle. ( 29415369 )
2018
3
Case Image: Percutaneous approach to giant coronary artery aneurysm: successful implantation of covered stent graft. ( 29339680 )
2018
4
Coronary Artery Aneurysm Formation: Kawasaki Disease versus Atherosclerosis. ( 29320319 )
2018
5
Coronary artery aneurysm regression after Kawasaki disease and associated risk factors: a 3-year follow-up study in East China. ( 29330741 )
2018
6
Self-apposing stent-assisted coil embolization for the treatment of coronary artery aneurysm. ( 28988417 )
2018
7
Coronary Artery Aneurysm Caused by a Stent Fracture. ( 29375112 )
2018
8
Ruptured coronary artery aneurysm with pulmonary artery fistulae. ( 29169210 )
2017
9
Endovascular coil treatment of a coronary artery aneurysm related to polyarteritis nodosa. ( 29145218 )
2017
10
Coronary Artery Aneurysm Presenting as Non-ST Elevation Myocardial Infarction. ( 29104831 )
2017
11
Coronary Artery Aneurysm After Bioresorbable Scaffold Implantation. ( 28667809 )
2017
12
Giant coronary artery aneurysm presenting as a right paracardial mass. ( 29169215 )
2017
13
Effectiveness of Bare Metal Stent Implantation for the Treatment of Coronary Artery Aneurysm: A Multimodality Imaging Evaluation. ( 29021434 )
2017
14
Coronary Artery Aneurysm After Bioresorbable Vascular Scaffold Implantation With Post-Dilation: Is Less More? ( 28017314 )
2017
15
Case 6/2017 - Extensive Giant Left Coronary Artery Aneurysm Due to Kawasaki Vasculitis in Asymptomatic 48-Year-Old Man. ( 29267630 )
2017
16
Multiple spontaneous intimal dissections with single left coronary artery and coronary artery aneurysm. ( 28433960 )
2017
17
Epidemiology and risk factors of coronary artery aneurysm in Taiwan: a population based case control study. ( 28667203 )
2017
18
Clinical outcomes of patients with coronary artery aneurysm after the first generation drug-eluting stent implantation. ( 29164770 )
2017
19
Difficult diagnosis of Kawasaki disease in a patient with giant coronary artery aneurysms. ( 28895991 )
2017
20
Surgical Repair of Bland-White-Garland Syndrome With Giant Right Coronary Artery Aneurysm. ( 29054232 )
2017
21
Computed tomography predict regression of coronary artery aneurysm in patients with Kawasaki disease. ( 28734587 )
2017
22
Multi-vessel giant coronary artery aneurysm in an elderly female. ( 28603725 )
2017
23
Transcatheter Closure of Congenital Coronary Artery Fistulas with a Giant Coronary Artery Aneurysm in Children: Experiences from a Single Center. ( 28776543 )
2017
24
Giant right coronary artery aneurysm mimicking sinus Valsalva aneurysm of the aorta. ( 29145232 )
2017
25
A case of ruptured infective coronary artery aneurysm. ( 28593611 )
2017
26
Rapidly growing coronary artery aneurysm associated with pericarditis. ( 28727582 )
2017
27
Repair of a coronary artery aneurysm in close proximity to the left main trunk. ( 28417513 )
2017
28
Giant Coronary Artery Aneurysm in a Middle-Aged Woman. ( 28359485 )
2017
29
Hybrid Management of a Giant Left Main Coronary Artery Aneurysm. ( 28007286 )
2017
30
Factors associated with development of coronary artery aneurysms after Kawasaki disease are similar for those treated promptly and those with delayed or no treatment. ( 28089146 )
2017
31
Giant left circumflex coronary artery aneurysm with fistula to the right atrium. ( 28745134 )
2017
32
Coronary-Artery Aneurysm in Tocilizumab-Treated Children with Kawasaki's Disease. ( 29117496 )
2017
33
Coronary artery aneurysm combined with other multiple aneurysms at multiple locations: A case report and systematic review. ( 29390352 )
2017
34
Coronary Artery Aneurysm With Thrombosis After Implantation of a Bioresorbable Coronary Artery Scaffold. ( 28935086 )
2017
35
A Giant Coronary Artery Aneurysm Treated Using Multiple Overlapping Covered Stents. ( 28624384 )
2017
36
Coronary Artery Aneurysm After Mini-Crush Drug-Eluting Stent Technique in a Chronic Total Occlusion. ( 28667810 )
2017
37
Infantile incomplete Kawasaki disease mimicking cervical purulent lymphadenitis with coronary artery aneurysm. ( 28786205 )
2017
38
Coronary artery aneurysm formation following implantation of a bioresorbable vascular scaffold for in-stent restenosis. ( 28579092 )
2017
39
Coronary Artery Aneurysm After Bioresorbable Scaffold Implantation in a Woman With an Acute Coronary Syndrome. ( 28667808 )
2017
40
Complex coronary artery aneurysm. ( 27862313 )
2017
41
Giant left main coronary artery aneurysm revealed by a myocardial infarction. ( 28819955 )
2017
42
Nonsurgical Management of a Giant Coronary Artery Aneurysm. ( 28944117 )
2017
43
Giant left anterior descending coronary artery aneurysm in an adult male patient with ST elevation myocardial infarction. ( 27021297 )
2016
44
Right Coronary Artery Aneurysm with Fistula to the Coronary Sinus, Persistent Left Superior Vena Cava, Ruptured Anterior Leaflet Chordae Tendineae with Severe Mitral Regurgitation. ( 26593222 )
2016
45
Giant Right Coronary Artery Aneurysm Associated with a Fistula Draining into the Superior Vena Cava. ( 27547153 )
2016
46
Giant Right Coronary Artery Aneurysm Mimicking a Mediastinal Cyst With Compression Effects: A Case Report. ( 27800453 )
2016
47
How should I treat a patient with giant left main coronary artery aneurysm without associated stenosis? ( 26788711 )
2016
48
Role of gender in types and frequency of coronary artery aneurysm and ectasia. ( 27495054 )
2016
49
From Small Coronary Artery Aneurysm to Giant Left Ventricle Aneurysm. ( 27603926 )
2016
50
Cardiac Complications in 38 Cases of Kawasaki Disease with Coronary Artery Aneurysm Diagnosed by Echocardiography. ( 26711003 )
2016

Variations for Coronary Artery Aneurysm

Expression for Coronary Artery Aneurysm

Search GEO for disease gene expression data for Coronary Artery Aneurysm.

Pathways for Coronary Artery Aneurysm

Pathways related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 ITPR3 MMP1 MMP12 MMP13 MMP3 MMP7
2
Show member pathways
12.54 MMP1 MMP12 MMP13 MMP3 MMP7 VCAM1
3
Show member pathways
12.46 ITPR3 MMP1 MMP13 PLCB1 PLCB4
4
Show member pathways
12.13 CCL2 MMP1 MMP13 MMP3
5
Show member pathways
12.05 CCL17 CCL2 MMP1 MMP13 MMP3
6 11.91 CCL2 LEP MMP12
7 11.87 ITPR3 PLCB1 PLCB4
8 11.86 KLK3 MMP13 MMP3 VCAM1
9 11.85 ITPR3 PLCB1 PLCB4
10 11.83 CCL2 MMP3 VCAM1
11 11.81 CCL2 MMP1 MMP3 VCAM1
12 11.8 ITPR3 PLCB1 PLCB4
13 11.76 ADIPOQ LEP VCAM1
14 11.76 ITPR3 PLCB1 PLCB4
15 11.73 CCL2 PLCB1 PLCB4 VCAM1
16 11.72 CCL2 MMP1 MMP3
17
Show member pathways
11.71 CCL17 CCL2 ITPR3 MMP1 MMP12 MMP13
18 11.7 ITPR3 PLCB1 PLCB4
19 11.61 CCL2 MMP13 MMP3 MMP7
20 11.56 ITPR3 PLCB1 PLCB4
21
Show member pathways
11.55 MMP1 MMP12 MMP13 MMP3 MMP7
22
Show member pathways
11.53 MMP1 MMP3 VCAM1
23 11.5 ITPR3 PLCB1 PLCB4
24 11.29 MMP13 PLCB1 PLCB4
25 11.23 PLCB1 PLCB4 VCAM1
26 11.21 ITPR3 PLCB1 PLCB4
27 11.18 ITPR3 PLCB1 PLCB4
28 10.92 CCL2 MMP1
29 10.89 KLK3 MMP1 MMP12 MMP13 MMP3 MMP7
30 10.86 MMP1 MMP7
31 10.82 CCL2 VCAM1

GO Terms for Coronary Artery Aneurysm

Cellular components related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ADIPOQ BAG6 CCL17 CCL2 KLK3 LEP
2 extracellular matrix GO:0031012 9.65 MMP1 MMP12 MMP13 MMP3 MMP7
3 proteinaceous extracellular matrix GO:0005578 9.55 MMP1 MMP12 MMP13 MMP3 MMP7
4 extracellular space GO:0005615 9.36 ADIPOQ CCL17 CCL2 KLK3 LEP MMP12

Biological processes related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.8 KLK3 MMP1 MMP12 MMP13 MMP3 MMP7
2 regulation of receptor activity GO:0010469 9.77 ADIPOQ CCL17 CCL2 LEP RETN
3 response to ethanol GO:0045471 9.65 ADIPOQ LEP VCAM1
4 response to nutrient GO:0007584 9.58 ADIPOQ LEP VCAM1
5 leukocyte tethering or rolling GO:0050901 9.46 LEP VCAM1
6 positive regulation of protein oligomerization GO:0032461 9.43 MMP1 MMP3
7 response to nutrient levels GO:0031667 9.43 ADIPOQ LEP MMP7
8 extracellular matrix disassembly GO:0022617 9.35 MMP1 MMP12 MMP13 MMP3 MMP7
9 positive regulation of developmental growth GO:0048639 9.16 LEP PLCB1
10 collagen catabolic process GO:0030574 9.02 MMP1 MMP12 MMP13 MMP3 MMP7

Molecular functions related to Coronary Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.97 ABHD16A KLK3 MMP1 MMP12 MMP13 MMP3
2 peptidase activity GO:0008233 9.85 KLK3 MMP1 MMP12 MMP13 MMP3 MMP7
3 receptor binding GO:0005102 9.8 ADIPOQ BAG6 CCL17 CCL2 LEP
4 hormone activity GO:0005179 9.63 ADIPOQ LEP RETN
5 endopeptidase activity GO:0004175 9.56 KLK3 MMP1 MMP12 MMP3
6 metallopeptidase activity GO:0008237 9.55 MMP1 MMP12 MMP13 MMP3 MMP7
7 phospholipase C activity GO:0004629 9.43 PLCB1 PLCB4
8 serine-type endopeptidase activity GO:0004252 9.43 KLK3 MMP1 MMP12 MMP13 MMP3 MMP7
9 metalloendopeptidase activity GO:0004222 9.02 MMP1 MMP12 MMP13 MMP3 MMP7

Sources for Coronary Artery Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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