MCID: CRN074
MIFTS: 34

Coronary Artery Aneurysm malady

Cardiovascular diseases category

Summaries for Coronary Artery Aneurysm

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63Wikipedia, 32MalaCards
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Wikipedia:63 Coronary artery aneurysm is an abnormal dilatation of part of the coronary artery. more...

MalaCards: Coronary Artery Aneurysm is related to kawasaki disease and endocarditis. An important gene associated with Coronary Artery Aneurysm is ITPKC (inositol-trisphosphate 3-kinase C), and among its related pathways are Rheumatoid arthritis and Apoptosis and survival Caspase cascade. The compounds endotoxin and tacrolimus have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Coronary Artery Aneurysm

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42NIH Rare Diseases, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

coronary artery aneurysm 42


External Ids:

ICD1025 I25.4

Related Diseases for Coronary Artery Aneurysm

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17GeneCards, 18GeneDecks
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Diseases in the Coronary Artery Aneurysm family:

Congenital Coronary Artery Aneurysm

Diseases related to Coronary Artery Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1kawasaki disease31.5CCL2, TIMP1, ITPKC
2endocarditis30.5PRF1
3atherosclerosis30.4CCL2, VCAM1, TIMP1, GZMB, TNF
4systemic lupus erythematosus30.4HLA-DRB1, HLA-DPB1, HLA-A, CCL2, TNF, VCAM1
5mixed connective tissue disease30.2HLA-A
6crohn's disease30.2TNF
7neutropenia30.2GZMB
8obesity30.2CCL2, TNF
9pneumonia30.2PRF1, TNF, CCL2
10vascular disease30.2TNF, HLA-C, TIMP1
11behcet's disease30.2HLA-C, HLA-B, HLA-A, TNF
12sarcoidosis30.1HLA-A, HLA-DRB1, HLA-C, TNF, GZMB, CCL2
13connective tissue disease30.1HLA-C, HLA-DRB1, HLA-A, TNF, CCL2, VCAM1
14rheumatoid arthritis30.1VCAM1, TIMP1, CCL2, GZMB, TNF, HLA-DPB1
15arthritis30.1HLA-A, HLA-DRB1, HLA-B, HLA-C, GZMB, CCL2
16coronary aneurysm11.5
17coronary artery disease11.1
18aneurysm disease11.1
19myocardial infarction10.9
20acute myocardial infarction10.7
21arteriovenous fistula10.6
22aortic aneurysm10.6
23coronary thrombosis10.6
24heart aneurysm10.5
25cardiac tamponade10.5
26coronary stenosis10.4
27mediastinitis10.4
28neurofibromatosis10.4
29dissecting aortic aneurysm10.4
30marfan syndrome10.3
31cerebritis10.3
32takayasu's arteritis10.3
33coronary artery vasospasm10.3
34coronary restenosis10.3
35patent ductus arteriosus10.3
36aortic disease10.3
37infective endocarditis10.3
38lupus erythematosus10.3
39congenital coronary artery aneurysm10.3
40mitral valve prolapse10.1
41pyuria10.1
42wolff-parkinson-white syndrome10.1
43supravalvular aortic stenosis10.1
44wegener's granulomatosis10.1
45aortitis10.1
46polyarteritis nodosa10.1
47splenic infarction10.1
48abdominal aortic aneurysm10.1
49tetralogy of fallot10.1
50myocardial stunning10.1

Graphical network of the top 20 diseases related to Coronary Artery Aneurysm:



Diseases related to coronary artery aneurysm

Clinical Features for Coronary Artery Aneurysm

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Drugs & Therapeutics for Coronary Artery Aneurysm

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Coronary Artery Aneurysm

Drug clinical trials:

Search ClinicalTrials for Coronary Artery Aneurysm

Search NIH Clinical Center for Coronary Artery Aneurysm

Search CenterWatch for Coronary Artery Aneurysm

Genetic Tests for Coronary Artery Aneurysm

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Anatomical Context for Coronary Artery Aneurysm

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Animal Models for Coronary Artery Aneurysm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Coronary Artery Aneurysm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.6CCL2, GZMB, TNF, HLA-E, ITPR3, PRF1
2MP:00053878.5VCAM1, TIMP1, CCL2, GZMB, TNF, HLA-B
3MP:00053978.5TIMP1, CCL2, GZMB, TNF, HLA-B, ITPKC

Publications for Coronary Artery Aneurysm

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Genetic Variations for Coronary Artery Aneurysm

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Expression for genes affiliated with Coronary Artery Aneurysm

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coronary Artery Aneurysm

Search GEO for disease gene expression data for Coronary Artery Aneurysm.

Pathways for genes affiliated with Coronary Artery Aneurysm

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Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 53Reactome, 55SinoBiological, 52R&D Systems
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Pathways related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HLA-DPB1
2
Apoptosis and survival Caspase cascade
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10.0PRF1, TNF, GZMB
39.9C2, HLA-DRB1, HLA-DPB1
4
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9.9PRF1, HLA-A, HLA-DRB1
5
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9.9GZMB, HLA-DRB1, HLA-A
69.9CCL2, TNF, VCAM1
79.8HLA-A, HLA-B, HLA-C
8
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9.8HLA-DRB1, HLA-DPB1, HLA-DQB2
9
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9.8HLA-DRB1, HLA-DPB1, HLA-DQB2
10
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9.8HLA-DQB2, HLA-DPB1, HLA-DRB1
11
Immune response Antigen presentation by MHC class II
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9.8HLA-DRB1, HLA-DPB1, HLA-DQB2
129.8HLA-DQB2, HLA-DPB1, HLA-DRB1
139.8GZMB, TNF, HLA-A, PRF1
149.7HLA-C, HLA-B, HLA-DPB1, HLA-E
15
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9.7C2, HLA-DRB1, HLA-DPB1, TNF
169.7HLA-C, HLA-B, HLA-E, HLA-A
17
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9.7HLA-C, HLA-B, HLA-E, HLA-A
18
Immune response IFN alpha/beta signaling pathway
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9.7HLA-C, HLA-B, HLA-E, HLA-A
199.7HLA-C, HLA-B, HLA-E, HLA-A
209.7HLA-C, HLA-B, HLA-E, HLA-A
21
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9.7HLA-A, HLA-E, HLA-B, HLA-C
229.6HLA-DQB2, HLA-DPB1, HLA-DRB1, ITPR3
239.6HLA-DQB2, HLA-DPB1, HLA-DRB1, ITPR3
24
Immune response ICOS pathway in T-helper cell
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9.6HLA-DQB2, HLA-DPB1, HLA-DRB1, ITPR3
25
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9.5HLA-A, HLA-E, HLA-DPB1, HLA-C, TNF
26
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9.5HLA-C, HLA-B, HLA-DRB1, HLA-E, HLA-A
27
Immune response NFAT in immune response
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9.4HLA-DQB2, HLA-DPB1, HLA-DRB1, ITPR3, IGHE
28
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9.3GZMB, TNF, HLA-C, HLA-B, HLA-E, HLA-A
299.3HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E, HLA-A
309.3HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E, HLA-A
31
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9.2HLA-C, HLA-B, HLA-E, HLA-A, ITPR3, IGHE
329.1HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E, HLA-A
33
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8.9CCL2, TNF, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1
34
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8.8HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E
35
Hide members
8.8PRF1, GZMB, TNF, HLA-C, HLA-B, HLA-DPB1
36
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8.7GZMB, TNF, HLA-C, HLA-B, HLA-E, HLA-A
37
Hide members
8.4HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E

Compounds for genes affiliated with Coronary Artery Aneurysm

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.6VCAM1
2tacrolimus44 49 1112.6TIMP1, GZMB
3dr-104410.5HLA-A, HLA-DRB1
4dpa 14410.4HLA-DRB1, HLA-DPB1
5chromium4410.4PRF1, GZMB, TIMP1
6listeriolysin4410.4PRF1, HLA-B
7ro 31-75494410.3TNF, VCAM1
8magnolol4410.3VCAM1, CCL2
9rantes4410.3HLA-B, GZMB, TNF
10dexamethasone44 49 28 1113.3TIMP1, GZMB, IGHE
11polymyxin b4410.3TNF, CCL2, VCAM1
12groalpha4410.3CCL2, TNF, VCAM1
13parthenolide44 211.3VCAM1, CCL2, TNF
148-isoprostane4410.2TNF, CCL2, VCAM1
15lipoteichoic acid4410.2TNF, HLA-B, CCL2
16alpha lipoic acid4410.2VCAM1, TNF, CCL2
17polyinosinic-polycytidylic acid4410.2VCAM1, HLA-B, TNF
18budesonide44 49 1112.2TNF, VCAM1, IGHE
19fluticasone propionate44 49 59 1113.1IGHE, TNF, VCAM1
20carbamazepine44 49 1112.1TNF, HLA-B, BAG6, PRRC2A
21pioglitazone44 49 28 1113.1TNF, CCL2, VCAM1, TIMP1
22diphenyleneiodonium4410.1CCL2, VCAM1, TNF
23atorvastatin44 49 28 11 2414.1CCL2, TIMP1, TNF, VCAM1
24rosiglitazone44 49 28 11 2414.1TIMP1, TNF, CCL2, VCAM1
25tgf beta14410.1TIMP1, TNF, VCAM1, CCL2
26prednisolone44 28 1112.0GZMB, TNF, IGHE, VCAM1
27herbimycin a44 5911.0CCL2, TIMP1, TNF, VCAM1
28l-nmma4410.0IGHE, VCAM1, TNF
29fenofibrate44 49 1112.0VCAM1, TNF, CCL2
30infliximab44 49 1112.0TIMP1, IGHE, TNF
31curcumin4410.0TIMP1, TNF, VCAM1, CCL2
32prostacyclin4410.0CCL2, VCAM1, TNF, TIMP1
33tarc4410.0IGHE, CCL2, TNF
34ly294002449.9CCL2, TIMP1, VCAM1, TNF, GZMB
35paraffin449.9TIMP1, GZMB, CCL2, HLA-B, VCAM1
36ivig449.9IGHE, TNF, GZMB
37aspartate449.9IGHE, ITPR3, VCAM1, HLA-B, CCL2
3815-deoxy-delta-12,14-prostaglandin j2449.9CCL2, TNF, VCAM1
39n acetylcysteine449.8VCAM1, IGHE, TNF, CCL2, TIMP1
40histamine44 28 2411.8CCL2, TIMP1, TNF, IGHE, VCAM1
41superoxide44 2410.7VCAM1, GZMB, CCL2, PRF1, TNF
42serine449.7GZMB, TIMP1, TNF, CCL2, HLA-B, C2
43lactate449.6IGHE, HLA-B, TNF, GZMB, TIMP1, VCAM1
44cyclosporin a44 28 5911.6HLA-A, HLA-B, TNF, TIMP1, IGHE, GZMB
45methotrexate44 49 1111.5TIMP1, TNF, HLA-DRB1, IGHE
46vegf449.5IGHE, TIMP1, GZMB, CCL2, TNF, VCAM1
47heparin44 28 11 2412.5ITPR3, GZMB, TIMP1, VCAM1
48nitric oxide44 11 2411.4TNF, HLA-B, VCAM1, GZMB, CCL2, TIMP1
49arginine449.3IGHE, TIMP1, CCL2, GZMB, HLA-B, HLA-DRB1
50alanine449.2GZMB, HLA-DRB1, HLA-A, TIMP1, IGHE, VCAM1

GO Terms for genes affiliated with Coronary Artery Aneurysm

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16Gene Ontology
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Cellular components related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.0HLA-DRB1, HLA-DPB1, HLA-DQB2
2clathrin-coated endocytic vesicle membraneGO:0306699.9HLA-DRB1, HLA-DPB1, HLA-DQB2
3MHC class I protein complexGO:0426129.9HLA-C, HLA-B, HLA-E, HLA-A
4phagocytic vesicle membraneGO:0306709.9HLA-C, HLA-B, HLA-E, HLA-A
5transport vesicle membraneGO:0306589.9HLA-DRB1, HLA-DPB1, HLA-DQB2
6early endosome membraneGO:0319019.8HLA-C, HLA-B, HLA-E, HLA-A
7trans-Golgi network membraneGO:0325889.8HLA-DQB2, HLA-DPB1, HLA-DRB1
8endocytic vesicle membraneGO:0306669.5HLA-DQB2, HLA-DPB1, HLA-DRB1
9integral to lumenal side of endoplasmic reticulum membraneGO:0715569.3HLA-A, HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1
10ER to Golgi transport vesicle membraneGO:0125079.3HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E
11Golgi membraneGO:0001399.2HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1, HLA-E
12extracellular regionGO:0055769.1C2, IGHE, PRF1, HLA-C, TNF, CCL2
13plasma membraneGO:0058868.2TNF, HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1

Biological processes related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.1TNF, VCAM1
2detection of bacteriumGO:01604510.1HLA-A, HLA-DRB1, HLA-B
3positive regulation of synaptic transmissionGO:05080610.0CCL2, TNF
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.0HLA-C, HLA-B, HLA-E, HLA-A
5positive regulation of T cell mediated cytotoxicityGO:00191610.0HLA-A, HLA-E, HLA-B, HLA-C
6type I interferon-mediated signaling pathwayGO:0603379.9HLA-C, HLA-B, HLA-E, HLA-A
7T cell costimulationGO:0312959.9HLA-DRB1, HLA-DPB1, HLA-DQB2
8agingGO:0075689.9VCAM1, CCL2, TIMP1
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.9HLA-C, HLA-B, HLA-E, HLA-A
10antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.9HLA-C, HLA-B, HLA-E, HLA-A
11antigen processing and presentation of peptide antigen via MHC class IGO:0024749.9HLA-A, HLA-E, HLA-B, HLA-C
12regulation of immune responseGO:0507769.8HLA-C, HLA-B, HLA-E, HLA-A, VCAM1
13T cell receptor signaling pathwayGO:0508529.7HLA-DRB1, HLA-DPB1, HLA-DQB2
14antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.5HLA-DQB2, HLA-DPB1, HLA-DRB1
15innate immune responseGO:0450879.4HLA-C, HLA-B, HLA-E, ITPR3, IGHE, C2
16immune responseGO:0069559.3HLA-DQB2, HLA-C, HLA-B, HLA-DRB1, HLA-A, IGHE
17interferon-gamma-mediated signaling pathwayGO:0603339.2VCAM1, HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1
18cytokine-mediated signaling pathwayGO:0192219.0CCL2, HLA-DQB2, HLA-C, HLA-B, HLA-DPB1, HLA-DRB1

Molecular functions related to Coronary Artery Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.0HLA-DRB1, HLA-DQB2
2peptide antigen bindingGO:0426059.4HLA-A, HLA-E, HLA-DRB1, HLA-B, HLA-C
3receptor bindingGO:0051029.2CCL2, HLA-C, HLA-B, HLA-E, HLA-A

Products for genes affiliated with Coronary Artery Aneurysm

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  • Antibodies
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Sources for Coronary Artery Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet