CHD
MCID: CRN018
MIFTS: 63

Coronary Artery Anomaly (CHD) malady

Cardiovascular diseases category
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Summaries for Coronary Artery Anomaly

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MedlinePlus:33 Coronary artery disease (cad) is the most common type of heart disease. it is the leading cause of death in the united states in both men and women. cad happens when the arteries that supply blood to heart muscle become hardened and narrowed. this is due to the buildup of cholesterol and other material, called plaque, on their inner walls. this buildup is called atherosclerosis. as it grows, less blood can flow through the arteries. as a result, the heart muscle can't get the blood or oxygen it needs. this can lead to chest pain (angina) or a heart attack. most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage. over time, cad can also weaken the heart muscle and contribute to heart failure and arrhythmias. heart failure means the heart can't pump blood well to the rest of the body. arrhythmias are changes in the normal beating rhythm of the heart. nih: national heart, lung, and blood institute

MalaCards based summary: Coronary Artery Anomaly, also known as coronary artery disease, is related to arteriosclerosis and insulin resistance. An important gene associated with Coronary Artery Anomaly is KL (klotho), and among its related pathways are Phase I, non P450 and Id Signaling Pathway. The drugs tirofiban and eptifibatide and the compounds paraoxon and phenol have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and bone, and related mouse phenotypes are cardiovascular system and immune system.

Disease Ontology:8 An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.

Wikipedia:65 Coronary artery anomalies (or malformation of coronary vessels) are congenital abnormalities in the... more...

Description from OMIM:46 607339

Aliases & Classifications for Coronary Artery Anomaly

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Coronary Artery Anomaly, Aliases & Descriptions:

Name: Coronary Artery Anomaly 30 8
Coronary Artery Disease 30 8 9 46 44 33
Coronary Heart Disease 8 46 10 44
Chd - Coronary Heart Disease 8 62
Chronic Myocardial Ischaemia 8 62
Coronary Arteriosclerosis 8 62
Myocardial Ischemia 8 44
Coronary Disease 8 62
Chd 8 38
 
Coronary Artery Disease, Susceptibility to 9
Coronary Heart Disease, Susceptibility to 9
Congenital Anomaly of Coronary Artery 8
Coronary Artery Anomaly, Congenital 8
Coronary Artery Anomaly Nos 8
Coronary Artery Abnormality 8
Ischaemic Heart Disease 62
Ischemic Heart Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Coronary Artery Anomaly

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Diseases related to Coronary Artery Anomaly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 350)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis31.2PON1
2insulin resistance31.1LPA, IRS1, PON1
3coronary stenosis31.0LPA, PON1
4diabetes mellitus31.0PON2, PON1, IRS1, LPA
5hypercholesterolemia30.9LPA, PON1, PON2
6hyperhomocysteinemia30.8PON1, LPA
7cerebrovascular disease30.8CX3CR1, PON1
8familial hypercholesterolemia30.8LPA, PON1, PON2
9type 2 diabetes mellitus30.8LPA, IRS1, PON1, PON2
10age related macular degeneration30.7CX3CR1
11myocardial infarction30.6LPA, PON1, PON2
12obesity30.5PON1, IRS1, LPA
13hypertriglyceridemia30.4LPA, IRS1, PON1
14polycystic ovary syndrome30.4PON1, IRS1
15glucose intolerance30.2IRS1, PON1
16hyperglycemia30.2LPA, IRS1, PON1
17breast cancer30.2LPA, IRS1, TERT
18hepatitis c30.2PON1, IRS1, CX3CR1
19hypothyroidism30.1LPA, PON1
20diabetic nephropathy30.0PON2, PON1, LPA
21uremia30.0PON1, LPA
22nephrotic syndrome29.9LPA, PON1
23familial hyperlipidemia29.7LPA, PON1
24prostate cancer29.7TERT, PON1, IRS1, CX3CR1
25rheumatoid arthritis29.5TERT, PON1, CX3CR1, LPA
26atherosclerosis29.4PON2, PON1, IRS1, CX3CR1, LPA
27endotheliitis11.1
28hypertension10.9
29chronic myocardial ischemia10.8
30hepatitis10.7
31peripheral vascular disease10.6
32vascular disease10.6
33aneurysm10.6
34blindness10.6
35aortic valve stenosis10.6
36aortic atherosclerosis10.5
37periodontitis10.5
38pneumonia10.5
39peripheral artery disease10.5
40congestive heart failure10.5
41familial combined hyperlipidemia10.5
42systolic heart failure10.5
43cerebritis10.5
44coronary thrombosis10.4
45aortic aneurysm10.4
46essential hypertension10.4
47influenza10.4
48carotid stenosis10.4
49kidney disease10.4
50generalized anxiety disorder10.3

Graphical network of the top 20 diseases related to Coronary Artery Anomaly:



Diseases related to coronary artery anomaly

Symptoms for Coronary Artery Anomaly

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Clinical features from OMIM:

607339

Drugs & Therapeutics for Coronary Artery Anomaly

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Drug clinical trials:

Search ClinicalTrials for Coronary Artery Anomaly

Search NIH Clinical Center for Coronary Artery Anomaly

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Coronary Artery Anomaly cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Coronary Artery Anomaly:
Enriched bone marrow-derived progenitor cells for heart diseases
Embryonic/Adult Cultured Cells Related to Coronary Artery Anomaly:
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868

Genetic Tests for Coronary Artery Anomaly

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Anatomical Context for Coronary Artery Anomaly

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MalaCards organs/tissues related to Coronary Artery Anomaly:

32
Heart, Lung, Bone

Animal Models for Coronary Artery Anomaly or affiliated genes

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MGI Mouse Phenotypes related to Coronary Artery Anomaly:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3PON2, PON1, IRS1, CX3CR1, KL
2MP:00053878.2KL, CX3CR1, IRS1, PON2, TERT
3MP:00053977.9TERT, PON2, IRS1, CX3CR1, KL
4MP:00053847.8KL, CX3CR1, IRS1, PON1, PON2, TERT
5MP:00053767.7TERT, PON2, PON1, IRS1, CX3CR1, KL

Publications for Coronary Artery Anomaly

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Articles related to Coronary Artery Anomaly:

(show top 50)    (show all 105)
idTitleAuthorsYear
1
Coronary artery anomaly: what does not fit the patient or the interpretation? (24943984)
2014
2
Reverse Anastomosis Technique for the Treatment of a Rare Coronary Artery Anomaly in D-Transposition of the Great Arteries. (24420677)
2014
3
Transcatheter coil embolization of a coronary artery-left ventricular fistula associated with single coronary artery anomaly. (24744954)
2014
4
Surgical Correction of an Aortico-Left Ventricular Tunnel Originating from the Left Aortic Sinus with a Left Coronary Artery Anomaly. (25395189)
2014
5
The prevalence and characteristics of intra-atrial right coronary artery anomaly in 9,284 patients referred for coronary computed tomography angiography. (24840476)
2014
6
Single coronary artery anomaly without previous myocardial infarction does not cause ischemic mitral insufficiency. (25122723)
2014
7
A rare case of a coronary artery anomaly detected on multidetector computed tomography. (24042514)
2013
8
Left descending coronary artery arising from anomalous distal circumflex coronary artery: a previously unreported coronary artery anomaly. (24089238)
2013
9
Interarterial course of coronary artery anomaly presenting as Brugada-like ECG and aborted cardiac death-Multidisciplinary images facilitate the diagnosis. (23958030)
2013
10
Novel coronary artery anomaly in an English Bulldog with pulmonic stenosis. (23869559)
2013
11
A young patient with coronary artery anomaly, whose left anterior descending artery originated from the pulmonary artery, underwent cardiac arrest. (23044527)
2012
12
Non-invasive detection of concomitant coronary artery anomaly and atherosclerotic coronary disease using transthoracic Doppler echocardiography. (22457690)
2012
13
Detection of a coronary artery anomaly after a sudden cardiac arrest in a 17 Year-old with D-transposition of the great arteries status post arterial switch operation: a case report. (21453426)
2011
14
Combined congenital coronary artery anomaly: dual left anterior descending coronary artery and absence of left circumflex artery. (21362600)
2011
15
Coronary artery bypass in a patient with complex coronary artery anomaly. (21885562)
2011
16
Diagnostic accuracy of dual-source multislice computed tomographic analysis for the preoperative detection of coronary artery anomalies in 100 patients with tetralogy of Fallot. (21292283)
2011
17
Single coronary artery anomaly: right coronary artery originating from the mid left anterior descending artery. (21646655)
2011
18
Single coronary artery but dual left anterior descending coronary artery anomaly. (21241975)
2011
19
Association of aortic coarctation and malignant right coronary artery anomaly: an unusual cause of angina pectoris. (23754906)
2011
20
Anomalous right coronary artery originating from the distal left circumflex artery: a novel coronary artery anomaly viewed by computed tomography and invasive angiography. (20548986)
2010
21
Malignant coronary artery anomaly in a survivor of Hodgkin's lymphoma. (20140607)
2010
22
A coronary artery anomaly: type IV dual left anterior descending artery. (20838724)
2010
23
Extremely rare R-I subtype coronary artery anomaly and accompanying incomplete myocardial bridging on the left anterior descending artery in a symptomatic patient: multidetector computed tomography and coronary angiography findings. (19626472)
2009
24
Sudden cardiac death associated with a coronary artery anomaly considered benign. (18178270)
2009
25
Percutaneous coronary intervention for acute myocardial infarction in a single coronary artery anomaly. (19816872)
2009
26
Single coronary artery anomaly: a report of three cases. (19155663)
2008
27
Coronary artery anomaly with congenital factor V deficiency. (19024144)
2008
28
Anomalous origin of the right coronary artery arising from the left anterior descending artery in a case with single coronary artery anomaly: multi-detector computer tomography imaging. (18849235)
2008
29
Anomalous origin of the right coronary artery from the left anterior descending artery in a patient with single left coronary artery: a rare coronary artery anomaly and review of the literature. (17658630)
2008
30
Incidental discovery of a rare single coronary artery anomaly by cardiac multidetector computed tomography. (19083920)
2008
31
A very rare case of single coronary artery anomaly, with left anterior descending and left circumflex arteries originating separately from proximal right coronary artery. (18290893)
2008
32
Right coronary artery arising as a terminal extension of the circumflex artery (a rare coronary artery anomaly). (17622398)
2007
33
Rare coronary artery anomaly: a single coronary artery arising from the right sinus of Valsalva. (17347101)
2007
34
Fatal coronary artery anomaly presenting as bronchiolitis. (16602012)
2006
35
Anomalous origin of the right coronary artery from the left anterior descending artery: a rare subtype of single coronary artery anomaly. (17040365)
2006
36
An unusual coronary artery anomaly in tetralogy of Fallot shown on MDCT. (16554603)
2006
37
A rare and potentially lethal coronary artery anomaly. (16844878)
2006
38
Fatal coronary artery anomaly presenting as bronchiolitis. (15889276)
2005
39
An unusual type of single coronary artery anomaly in a patient with hypertrophic obstructive cardiomyopathy. (16140658)
2005
40
Exercise-related sudden death due to an unusual coronary artery anomaly. (14767237)
2004
41
Double left anterior descending coronary artery arising from the left and right coronary arteries: a rare congenital coronary artery anomaly. (15278394)
2004
42
Congenital coronary artery anomaly simulating an acute aortic dissection. (14966072)
2004
43
Double left anterior descending artery arising from the left main stem and right sinus of Valsalva: an extremely rare coronary artery anomaly. (14609307)
2003
44
Silent single coronary artery anomaly depicted by magnetic resonance angiography. (12042625)
2002
45
Detection of malignant right coronary artery anomaly by multi-slice CT coronary angiography. (12522635)
2002
46
Images in cardiovascular medicine. Malignant right coronary artery anomaly detected by magnetic resonance coronary angiography. (12356645)
2002
47
Unusual right coronary artery anomaly with major implication during cardiac operations. (9307486)
1997
48
Isolated corrected transposition of great arteries and double left anterior descending artery originating from the left and right coronary artery. A rate combination of coronary artery anomaly and congenital heart disease. (8546348)
1996
49
A new double coronary artery anomaly: the right coronary artery originating above the coronary sinus giving off the circumflex artery. (6501733)
1984
50
Fatal myocardial infarction in an 11 year old boy associated with a unique coronary artery anomaly. (6020311)
1967

Variations for Coronary Artery Anomaly

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Expression for genes affiliated with Coronary Artery Anomaly

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Expression patterns in normal tissues for genes affiliated with Coronary Artery Anomaly

Search GEO for disease gene expression data for Coronary Artery Anomaly.

Pathways for genes affiliated with Coronary Artery Anomaly

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Pathways related to Coronary Artery Anomaly according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5PON1, PON2
29.4IRS1, TERT

Compounds for genes affiliated with Coronary Artery Anomaly

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Compounds related to Coronary Artery Anomaly according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1paraoxon44 2410.8PON1, PON2
2phenol44 2410.7PON1, PON2
3parathion44 2410.7PON1, PON2
41-Hexanol249.5KL, PON2, PON1
5Propyl alcohol249.5PON2, PON1, KL
6Isopropyl alcohol249.5PON2, PON1, KL
7Isobutanol249.5PON2, PON1, KL
81-Pentanol249.5PON2, PON1, KL
91-Butanol249.5PON2, PON1, KL
10hocl449.5PON1, LPA
11gemfibrozil28 44 1111.5PON1, LPA
12cholesterol ester449.4PON1, LPA
13fenofibrate44 50 1111.4PON1, LPA
14vitamin b12449.3LPA, PON1
15phospholipid449.3IRS1, PON1, PON2
16malondialdehyde449.3LPA, PON1
17uric acid44 2410.3PON1, LPA
18vitamin-e449.2LPA, PON1
19lovastatin44 50 61 28 1113.1PON1, IRS1, LPA
20rosiglitazone28 44 50 24 1113.1LPA, IRS1, PON1
21aspirin44 50 28 2412.1LPA, IRS1, PON1
22pravastatin44 50 28 24 1113.1LPA, PON1
23ethanol44 50 24 1111.7KL, LPA, PON1, PON2
24testosterone44 61 24 1111.7TERT, PON1, IRS1
25cholesterol44 28 24 1111.7LPA, PON1, PON2
26vegf448.6KL, LPA, CX3CR1, TERT
27glucose448.5LPA, IRS1, PON1, PON2
28h2o2448.5TERT, PON1, IRS1, LPA
29arginine448.5TERT, PON1, IRS1, LPA
30estrogen448.5TERT, PON1, IRS1, LPA
31lipid448.0TERT, PON2, PON1, IRS1, LPA

GO Terms for genes affiliated with Coronary Artery Anomaly

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Cellular components related to Coronary Artery Anomaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.3KL, LPA, PON1, PON2

Biological processes related to Coronary Artery Anomaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5CX3CR1, TERT
2aromatic compound catabolic processGO:0194399.2PON1, PON2

Molecular functions related to Coronary Artery Anomaly according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1arylesterase activityGO:0040649.5PON1, PON2

Products for genes affiliated with Coronary Artery Anomaly

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  • Antibodies
  • Proteins
  • Lysates

Sources for Coronary Artery Anomaly

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet