CHD
MCID: CRN211
MIFTS: 84

Coronary Artery Disease (CHD) malady

Cardiovascular diseases category
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Summaries for Coronary Artery Disease

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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Fully expand this MalaCard
MedlinePlus:34 Coronary artery disease (cad) is the most common type of heart disease. it is the leading cause of death in the united states in both men and women. cad happens when the arteries that supply blood to heart muscle become hardened and narrowed. this is due to the buildup of cholesterol and other material, called plaque, on their inner walls. this buildup is called atherosclerosis. as it grows, less blood can flow through the arteries. as a result, the heart muscle can't get the blood or oxygen it needs. this can lead to chest pain (angina) or a heart attack. most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage. over time, cad can also weaken the heart muscle and contribute to heart failure and arrhythmias. heart failure means the heart can't pump blood well to the rest of the body. arrhythmias are changes in the normal beating rhythm of the heart. nih: national heart, lung, and blood institute

MalaCards: Coronary Artery Disease, also known as coronary heart disease, is related to myocardial infarction and diabetes mellitus. An important gene associated with Coronary Artery Disease is PON1 (paraoxonase 1), and among its related pathways are Phase I, non P450 and Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF . The compounds cholesterol ester and lovastatin have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and endothelial, and related mouse phenotypes are renal/urinary system and adipose tissue.

Disease Ontology:8 An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.

Wikipedia:65 Coronary artery disease (CAD) also known as atherosclerotic heart disease,coronary heart disease, or... more...

Description from OMIM:47 607339

Aliases & Classifications for Coronary Artery Disease

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Sources:
31LifeMap Discovery™, 8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 39NCBI Bookshelf, 34MedlinePlus, 58SNOMED-CT, 27ICD9CM, 62UMLS, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

coronary artery disease 31 8 9 47 45 34
coronary heart disease 8 47 10 45
ischemic heart disease 8 10
myocardial ischemia 8 45
chd 8 39
coronary artery disease, susceptibility to 9
coronary heart disease, susceptibility to 9
congenital anomaly of coronary artery 8
coronary artery anomaly, congenital 8
chronic myocardial ischaemia 8
chd - coronary heart disease 8
coronary artery abnormality 8
coronary artery anomaly nos 8
coronary arteriosclerosis 8
coronary artery anomaly 8
coronary disease 8
ihd 39


Related Diseases for Coronary Artery Disease

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Coronary Artery Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 358)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.7APOA1, ABCA1, CYBA, P2RY12, APOA5, PON2
2diabetes mellitus31.5CCL2, APOA1, APOA5, PON2, PON1, IRS1
3atherosclerosis31.5CX3CR1, P2RY12, IRS1, PON1, PON2, APOA5
4hypertension31.5CYBA, LPA, CCL2, ACE, APOA1
5insulin resistance31.5MEF2A, LPA, PON1, CCL2, ACE, IRS1
6type 2 diabetes mellitus31.3PON2, APOA1, ABCA1, PON1, IRS1, LPA
7hypercholesterolemia31.3LPA, ACE, APOA1, CYBA, ABCA1, PON1
8acute myocardial infarction31.1LPA, APOA1, PON1, ACE
9coronary stenosis31.1LPA, PON1, APOA1
10familial hypercholesterolemia31.1PON2, PON1, LPA, APOA1
11peripheral vascular disease31.1APOA1, ACE, LPA
12hyperhomocysteinemia31.1CCL2, PON1, LPA
13obesity31.0LPA, APOA1, PON1, CCL2, APOA5, ABCA1
14vascular disease31.0HP
15familial combined hyperlipidemia30.9APOA1, PON1, APOA5
16arteriosclerosis30.8PON1, APOA1, CCL2
17essential hypertension30.8HP, CYBA, APOA1, PON1, LPA, ACE
18cerebrovascular disease30.7ACE, PON1, APOA1, CX3CR1
19hypertriglyceridemia30.7APOA5, APOA1, PON1, IRS1, ABCA1, LPA
20hypoalphalipoproteinemia30.6APOA1, ABCA1
21tangier disease30.6APOA1, LPA, ABCA1
22alzheimer's disease30.6PON1, ABCA1, PON2, LPA, MEF2A
23hyperglycemia30.5IRS1, LPA, ACE, PON1
24diabetic nephropathy30.5PON2, APOA1, LPA, CCL2, ACE, HP
25polycystic ovary syndrome30.4IRS1, PON1, APOA1
26cerebral atherosclerosis30.3APOA1
27hyperlipidemia type 330.2LPA, APOA1, APOA5
28familial hyperlipidemia30.2LPA, APOA5, APOA1
29multiple sclerosis30.2CCL2, CX3CR1, PON1, APOA1
30nephrotic syndrome30.2PON1, HP, LPA, APOA1, ACE
31proteinuria30.2CCL2, LPA, ACE, APOA1, HP
32familial hypertriglyceridemia30.2APOA1, APOA5
33hyperalphalipoproteinemia30.2ABCA1, APOA1
34glomerulonephritis30.2PON1, LPA, CCL2
35congenital heart disease30.2CCL2, ACE, HP
36systemic scleroderma30.2CX3CR1, ACE, CCL2
37hypothyroidism30.2LPA, PON1
38hepatitis c30.2IRS1, CX3CR1, HP, PON1
39glucose intolerance30.2PON1, IRS1, APOA1
40rheumatoid arthritis30.1PON1, APOA1, TERT, LPA, CCL2, HP
41prostate cancer30.0TERT, PON1, IRS1, CX3CR1, ABCA1
42artery disease11.7
43endotheliitis11.1
44ischemia10.8
45angina pectoris10.7
46hepatitis10.6
47blindness10.6
48aneurysm10.5
49aortic valve stenosis10.5
50pneumonia10.5

Graphical network of the top 20 diseases related to Coronary Artery Disease:



Diseases related to coronary artery disease

Symptoms for Coronary Artery Disease

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Sources:
47OMIM
See all sources


Clinical features from OMIM:

607339

Drugs & Therapeutics for Coronary Artery Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Coronary Artery Disease

Search NIH Clinical Center for Coronary Artery Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Coronary Artery Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Coronary Artery Disease:
ACT34-CMI, bone marrow-derived cells for ischemic heart diseases
Adipocell
Adipose-derived mesenchymal stromal stem cells for ischemic heart disease
ADRCs, adipose-derived regenerative cells for treatment of cardiovascular disease
AMDC, autologous muscle-derived cells for ischemic heart failure
Autologous bone marrow-derived mesenchymal stem cells for treatment of heart muscle damage
Bone marrow-derived CD133+ stem cells for treatment of ischemic heart disease
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mesenchymal stem cells for treatment of ischemic heart disease
Bone marrow-derived mononuclear cells for ischemic cardiomyopathy
Bone marrow-derived mononucleated cells for heart disease
Bone marrow-derived stem cells for treatment of chronic ischemic heart failure
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived stem cells for treatment of severe chronic ischemic heart disease
Cardiac stem cells for treatment of ischemic cardiomyopathy
Cardiocell
CD34+ stem cells for treatment of congestive heart failure
Combination therapy of mononuclear cells with laser for coronary disease
Embryonic stem cell-derived cardiomyocytes for ischemic myocardium
Enriched bone marrow-derived progenitor cells for heart diseases
Enriched bone marrow-derived progenitor cells for heart diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
Peripheral mononuclear cells CD34+ stem cells for treatment of myocardial ischemia
Peripheral or bone marrow-derived stem cells for chronic heart failure
StempeucelICM
Embryonic/Adult Cultured Cells Related to Coronary Artery Disease:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 11283669, 12551872, 22163120, 20448213, 9020076, 17562958, 21737787
VEGF-A165-stimulated ADSCs
Adipose-derived stem and regenerative cell, PMIDs: 21082397, 22281257
Autologous muscle-derived cells
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived CD133+ cells
Bone marrow-derived mesenchymal stem cells , PMID: 22940024
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21052537, 19591227
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived stem cells
Bone marrow-derived mesenchymal stem cells , PMIDs: 21392602, 22940024
Bone marrow-derived mononuclear cells (family), PMIDs: 21392602, 22940024
Porcine bone marrow-derived mesenchymal stem cells, PMIDs: 21392602, 22940024
Human cardiac stem cells, PMIDs: 22088800, 22965994
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived hematopoietic stem cells (family), PMID: 22163120
Bone marrow-derived mononuclear cells (family)
Cardiomyocyte-like cells, PMID: 18941512
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Bone marrow-derived mononuclear cells, PMIDs: 21323410, 20631864
Bone marrow-derived mesenchymal stem cells, PMIDs: 21323410, 20631864
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Coronary Artery Disease

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Anatomical Context for Coronary Artery Disease

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Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Coronary Artery Disease:

33
Heart, Bone, Endothelial, Monocytes, Lung, Testes, Kidney, Brain, Liver, Bone marrow, Adipocyte, Smooth muscle, Pons, Thyroid, Prostate, Ovary, T cells, Whole blood, Pituitary, B cells, Breast, Colon, Skeletal muscle, Skin

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Coronary Artery Disease:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Coronary Artery Disease or affiliated genes

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Sources:
37MGI
See all sources

Publications for Coronary Artery Disease

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Sources:
52PubMed
See all sources

Articles related to Coronary Artery Disease:

(show top 50)    (show all 2789)
idTitleAuthorsYear
1
Relationship between cytochrome P450 2C19*17 genotype distribution, platelet aggregation and bleeding risk in patients with blood stasis syndrome of coronary artery disease treated with clopidogrel. (22704413)
2012
2
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. (21701070)
2011
3
Association of 25 bp deletion in MYBPC3 gene with left ventricle dysfunction in coronary artery disease patients. (21915287)
2011
4
Association of serum TRAIL level with coronary artery disease. (20034655)
2010
5
Associations between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and coronary artery disease in a Tunisian population. (21130966)
2010
6
Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease. (20009357)
2010
7
Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease. (19562259)
2010
8
Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. (19074676)
2009
9
Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease. (19429918)
2009
10
Interleukin-3 is elevated in patients with coronary artery disease and predicts restenosis after percutaneous coronary intervention. (18378332)
2009
11
The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease. (19217458)
2009
12
Insulin response to oral glucose load is associated with coronary artery disease in subjects with normal glucose tolerance. (18270458)
2008
13
Human paraoxonase gene polymorphisms and coronary artery disease risk. (19280995)
2008
14
Five-year follow-up of drug utilization for secondary prevention in coronary artery disease. (18563622)
2008
15
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (18193043)
2008
16
The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. (18068006)
2008
17
Myeloperoxidase level in patients with stable coronary artery disease and acute coronary syndromes. (18226042)
2008
18
Homocysteinemia as an independent risk factor in the Chinese population at a high risk of coronary artery disease. (17659928)
2007
19
Factors influencing thrombin generation measured as thrombin-antithrombin complexes levels and using calibrated automated thrombogram in patients with advanced coronary artery disease]. (17966595)
2007
20
The value of percutaneous coronary intervention in aortic valve stenosis with coronary artery disease. (17275462)
2007
21
Association of the MspI polymorphism of cytochrome P4501A1 gene and smoking to the susceptibility to coronary artery disease]. (17711714)
2007
22
DNA repair gene XRCC1 and XPD polymorphisms and their association with coronary artery disease risks and micronucleus frequency. (18043991)
2007
23
Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. (17259397)
2007
24
Angiotensin-I-converting enzyme (ACE) insertion/deletion polymorphism in Mexican patients with coronary artery disease. Association with the disease but not with lipid levels. (16764852)
2006
25
The CAREGENE study: ACE gene I/D polymorphism and effect of physical training on aerobic power in coronary artery disease. (16085717)
2006
26
ACE inhibition in stable coronary artery disease. (15751129)
2005
27
High serum interleukin-18 concentrations in patients with coronary artery disease and type 2 diabetes mellitus. (16266856)
2005
28
Usefulness of high-sensitivity IL-6 measurement for clinical characterization of patients with coronary artery disease. (15900566)
2005
29
Association of plasma cholesteryl ester transfer protein activity and polymorphism with coronary artery disease extent in Tunisian type II diabetic patients. (15766738)
2005
30
Association of oestrogen receptor alpha gene polymorphism with the angiographic extent of coronary artery disease. (14972425)
2004
31
Role of angiogenic growth factors in transplant coronary artery disease. (15181974)
2004
32
Effects of statins on coronary artery disease. Review of the recent publications]. (12884643)
2003
33
Molecular analysis of the estrogen receptor alpha gene in men with coronary artery disease: association with disease status. (12691862)
2003
34
Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. (12454802)
2003
35
Enhanced bridging function and augmented monocyte adhesion by lipoprotein lipase N9: insights into increased risk of coronary artery disease in N9 carriers. (12535736)
2003
36
Relation of markers of inflammation (C-reactive protein, fibrinogen, von Willebrand factor, and leukocyte count) and statin therapy to long-term mortality in patients with angiographically proven coronary artery disease. (11950425)
2002
37
Coronary artery disease in systemic lupus erythematosus: A review of the literature. (11404827)
2001
38
Soluble adhesion molecules and unstable coronary artery disease. (11395039)
2001
39
Lack of evidence for association between endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in the Australian Caucasian population. (11551002)
2001
40
Effects of fluvastatin and bezafibrate combination on plasma fibrinogen, t-plasminogen activator inhibitor and C reactive protein levels in coronary artery disease patients with mixed hyperlipidaemia (FACT Study)--a rebuttal. (11204580)
2001
41
Low apolipoprotein A-IV plasma concentrations in men with coronary artery disease. (10987595)
2000
42
Relevance of apolipoprotein E polymorphism for coronary artery disease in the Saudi population. (10583930)
1999
43
The prothrombin 20210A allele and the factor V Leiden are associated with venous thrombosis but not with early coronary artery disease. (10070834)
1999
44
Mechanism by which quinapril improves vascular function in coronary artery disease. (10072217)
1999
45
Pharmacology of carvedilol: rationale for use in hypertension, coronary artery disease, and congestive heart failure. (9211017)
1997
46
Recombinant hirudin in patients with chronic, stable coronary artery disease. Safety, half-life, and effect on coagulation parameters. (8222093)
1993
47
Familial hypoalphalipoproteinemia in premature coronary artery disease. (8241092)
1993
48
Thrombolysis with recombinant human tissue-type plasminogen activator during instability in coronary artery disease: effect on myocardial ischemia and need for coronary revascularization. TRIC Study Group. (1462894)
1992
49
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. (3081805)
1986
50
Fibrinolytic activity in coronary artery disease and myocardial infarction, and the role of fibrinolytic therapy in coronary thrombosis. (5648576)
1968

Variations for Coronary Artery Disease

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Sources:
1 National Center for Biotechnology Information (Clinvar)
See all sources

Clinvar genetic disease variations for Coronary Artery Disease:

1
id Gene Name Type Significance SNP ID Assembly Location
1APOC3NM_000040.1(APOC3): c.55C> T (p.Arg19Ter)single nucleotide variantPathogenic, protectivers76353203GRCh37Chr 11, 116701353: 116701353

Expression for genes affiliated with Coronary Artery Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Coronary Artery Disease

Search GEO for disease gene expression data for Coronary Artery Disease.

Pathways for genes affiliated with Coronary Artery Disease

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 54R&D Systems, 12EMD Millipore, 55Reactome, 51PharmGKB, 30KEGG
See all sources

Compounds for genes affiliated with Coronary Artery Disease

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Sources:
45Novoseek, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 3BitterDB
See all sources

Compounds related to Coronary Artery Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1cholesterol ester4510.8HP, ABCA1, APOA1, PON1, LPA
2lovastatin45 51 61 29 1114.7APOA1, IRS1, PON1, LPA, APOA5
3probucol45 1111.7APOA1, ABCA1, HP, CCL2
4vitamin b124510.7LPA, APOA1, PON1, CCL2, HP
5vitamin-e4510.7LPA, ABCA1, CYBA, PON1, HP
6rosiglitazone29 45 51 24 1114.7PON1, ABCA1, IRS1, CCL2, LPA
7hocl4510.7CYBA, PON1, LPA
8niacin45 1111.7ABCA1, APOA1, HP, LPA
9dimyristoylphosphatidylcholine4510.7APOA5, LPA, APOA1
10fenofibrate45 51 1112.7CCL2, APOA1, APOA5, ABCA1, LPA, PON1
11homocysteine45 2411.7APOA1, LPA, CCL2, HP, PON1
12fluvastatin45 51 29 1113.7ACE, CYBA, APOA1, PON1, CCL2
13hind iii4510.7ABCA1, HP, LPA
141-Pentanol2410.7KL, PON1, PON2
15uric acid45 2411.7APOA1, PON1, LPA, HP
16pravastatin45 51 29 24 1114.7PON1, ABCA1, LPA, ACE, APOA1, CCL2
171-Hexanol2410.7PON2, PON1, KL
18phospholipid4510.7PON1, APOA1, IRS1, ABCA1, HP, PON2
19pioglitazone29 45 51 1113.7ABCA1, APOA1, CCL2, IRS1
20Propyl alcohol2410.7PON2, KL, PON1
21phosphatidylcholine4510.7PON1, LPA, ABCA1, CCL2, APOA1
22atorvastatin45 51 29 24 1114.7PON1, APOA5, CCL2, ACE, ABCA1, LPA
23ethanol45 51 24 1113.7KL, HP, PON2, LPA, PON1
24Isobutanol2410.7KL, PON1, PON2
25simvastatin45 51 61 29 24 1115.7CYBA, APOA1, ABCA1, LPA, APOA5, PON1
26Isopropyl alcohol2410.7KL, PON1, PON2
27aspirin45 51 29 2413.7LPA, ACE, HP, P2RY12, IRS1, PON1
28fibrinogen4510.7LPA, HP, PON1, ABCA1, APOA1, P2RY12
29h2o24510.7IRS1, PON1, APOA1, CYBA, TERT, LPA
301-Butanol2410.7PON2, PON1, KL
31testosterone45 61 24 1113.6PON1, HP, CCL2, ABCA1, IRS1, TERT
32creatinine4510.6CCL2, PON1, P2RY12, HP, ACE, MEF2A
33phosphatidylinositol4510.6CCL2, MEF2A, CX3CR1, P2RY12, IRS1, ABCA1
34ly2940024510.6IRS1, MEF2A, CCL2, P2RY12, TERT
35nitric oxide45 24 1112.6CYBA, LPA, ABCA1, CCL2, ACE, HP
36cholesterol45 29 24 1113.6LPA, PON1, APOA1, APOA5, CYBA, ABCA1
37gemfibrozil29 45 1112.6LPA, APOA1, PON1
38serine4510.6ABCA1, TERT, APOA1, PON1, IRS1, MEF2A
39glucose4510.6LPA, IRS1, MEF2A, CCL2, ACE, HP
40calcium45 51 24 1113.5TERT, ABCA1, CYBA, P2RY12, CX3CR1, LPA
41lipid4510.5APOA1, ABCA1, CYBA, APOA5, PON2, IRS1
42thyroxine45 2411.5LPA, APOA1, PON1, HP
43dexamethasone45 51 29 1113.5CCL2, APOA1, HP, ABCA1, CYBA, IRS1
44genistein45 29 61 3 24 1115.4ABCA1, TERT, APOA1, IRS1, CCL2
45tyrosine4510.4CYBA, TERT, ABCA1, IRS1, P2RY12, HP
468-isoprostane4510.4HP, CCL2, PON1
47vegf4510.4HP, CCL2, LPA, CX3CR1, TERT, KL
48fatty acid4510.3LPA, APOA5, IRS1, ABCA1, MEF2A
49arginine4510.2TERT, PON1, IRS1, LPA, MEF2A, CCL2
50clopidogrel45 51 24 1113.1P2RY12, PON1, ACE

GO Terms for genes affiliated with Coronary Artery Disease

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Sources:
16Gene Ontology
See all sources

Cellular components related to Coronary Artery Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:03436410.6PON1, APOC4, APOA5, APOA1
2very-low-density lipoprotein particleGO:03436110.5APOA1, APOA5, APOC4
3caveolaGO:00590110.4P2RY12, IRS1, LRP6
4spherical high-density lipoprotein particleGO:03436610.4APOA1, PON1
5extracellular regionGO:00557610.4APOA1, APOA5, PON2, PON1, LPA, CCL2
6blood microparticleGO:07256210.4HP, PON1, APOA1
7extracellular spaceGO:00561510.4APOA1, APOA5, PON1, CCL2, ACE, HP
8endocytic vesicle lumenGO:07168210.1HP, APOA1
9plasma membraneGO:00588610.1ABCA1, LRP6, APOA1, PON2, IRS1, P2RY12

Biological processes related to Coronary Artery Disease according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1aromatic compound catabolic processGO:01943910.7PON2, PON1
2regulation of Cdc42 protein signal transductionGO:03248910.7ABCA1, APOA1
3triglyceride homeostasisGO:07032810.7APOA1, APOA5, APOC4
4protein kinase B signalingGO:04349110.7CCL2, P2RY12, IRS1
5high-density lipoprotein particle assemblyGO:03438010.7APOA1, ABCA1
6lipoprotein metabolic processGO:04215710.7LPA, APOA5, APOA1, ABCA1
7organ regenerationGO:03110010.7APOA1, APOA5, CCL2
8cerebral cortex cell migrationGO:02179510.7CX3CR1, LRP6
9cellular response to lipopolysaccharideGO:07122210.7CCL2, CX3CR1, ABCA1
10cholesterol homeostasisGO:04263210.6ABCA1, APOA1, APOA5
11phospholipid effluxGO:03370010.6APOA1, ABCA1
12phospholipid homeostasisGO:05509110.6APOA1, ABCA1
13positive regulation of cholesterol effluxGO:01087510.6PON1, ABCA1
14response to drugGO:04249310.6ABCA1, CYBA, APOA1, CCL2
15cellular response to cholesterolGO:07139710.5ABCA1, LRP6
16G-protein coupled receptor signaling pathwayGO:00718610.5ABCA1, APOA1, CX3CR1, CCL2
17macrophage chemotaxisGO:04824610.5CCL2, CX3CR1
18chemokine-mediated signaling pathwayGO:07009810.4CCL2, CX3CR1
19reverse cholesterol transportGO:04369110.4APOA1, ABCA1
20cellular lipid metabolic processGO:04425510.3ABCA1, APOA1, APOA5
21cholesterol effluxGO:03334410.1APOA1, ABCA1

Molecular functions related to Coronary Artery Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:00554310.5PON1, APOA5, APOA1, ABCA1
2apolipoprotein bindingGO:03418510.4LPA, LRP6, ABCA1
3arylesterase activityGO:00406410.4PON2, PON1
4heparin bindingGO:00820110.4CCL2, LPA, APOA5
5phospholipid transporter activityGO:00554810.3APOA1, ABCA1
6cholesterol transporter activityGO:01712710.1APOA1, ABCA1

Products for genes affiliated with Coronary Artery Disease

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  • Antibodies
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Sources for Coronary Artery Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet