Coronary Artery Disease, Modifier of malady

MalaCards: Coronary Artery Disease, Modifier of, also known as coronary arteriosclerosis, is related to arteriosclerosis and ischemic heart disease. An important gene associated with Coronary Artery Disease, Modifier of is CCL2 (chemokine (C-C motif) ligand 2), and among its related pathways are Renin-Angiotensin Pathway and Chagas disease (American trypanosomiasis). The compounds olmesartan and valsartan have been mentioned in the context of this disorder.

coronary artery disease, modifier of 33 coronary arteriosclerosis 43

Diseases related to coronary artery disease, modifier of by text searches and GeneDecks gene sharing:

(show top 50)    (show all 110)

id	Related Disease	Score	Top Affiliating Genes
1	arteriosclerosis	33.0	ACE, CCL2
2	ischemic heart disease	28.7	CCL2, ACE
3	coronary artery anomaly	28.6	ACE, CCL2
4	carotid artery disease	12.7	ACE, CCL2
5	steroid-resistant nephrotic syndrome	12.7	ACE, CCL2
6	nephrosclerosis	12.7	ACE, CCL2
7	peripheral arterial occlusive disease	12.7	ACE, CCL2
8	eosinophilic pneumonia	12.7	ACE, CCL2
9	retinal vein occlusion	12.6	CCL2, ACE
10	arterial occlusive disease	12.6	ACE, CCL2
11	pulmonary plasma cell granuloma	12.6	ACE, CCL2
12	aortic valve stenosis	12.6	CCL2, ACE
13	primary pulmonary hypertension	12.6	ACE, CCL2
14	iga glomerulonephritis	12.6	ACE, CCL2
15	pyelonephritis	12.6	ACE, CCL2
16	glomerulopathy	12.6	ACE, CCL2
17	paine syndrome	12.6	ACE, CCL2
18	gaucher's disease	12.6	ACE, CCL2
19	arterial calcification	12.6	ACE, CCL2
20	juvenile rheumatoid arthritis	12.6	ACE, CCL2
21	bronchopulmonary dysplasia	12.6	CCL2, ACE
22	aggressive periodontitis	12.6	ACE, CCL2
23	pulmonary sarcoidosis	12.6	ACE, CCL2
24	cerebral malaria	12.6	ACE, CCL2
25	headache	12.6	CCL2, ACE
26	retinol binding protein	12.6	CCL2, ACE
27	proliferative diabetic retinopathy	12.6	CCL2, ACE
28	obesity, association with	12.6	CCL2, ACE
29	hepatopulmonary syndrome	12.6	CCL2, ACE
30	hyperhomocysteinemia	12.6	ACE, CCL2
31	glucose intolerance	12.6	ACE, CCL2
32	interstitial lung disease	12.6	ACE, CCL2
33	hemochromatosis	12.6	CCL2, ACE
34	severe acute respiratory syndrome	12.6	ACE, CCL2
35	hernia	12.6	CCL2, ACE
36	urticaria	12.6	CCL2, ACE
37	cerebrovascular accident	12.6	ACE, CCL2
38	focal segmental glomerulosclerosis	12.6	CCL2, ACE
39	sleep apnea	12.6	CCL2, ACE
40	traumatic brain injury	12.6	CCL2, ACE
41	connective tissue disease	12.6	ACE, CCL2
42	trypanosomiasis	12.6	ACE, CCL2
43	psoriatic arthritis	12.6	CCL2, ACE
44	gestational diabetes	12.6	ACE, CCL2
45	myasthenia gravis	12.6	CCL2, ACE
46	apnea	12.6	CCL2, ACE
47	uveitis	12.6	ACE, CCL2
48	lupus nephritis	12.6	ACE, CCL2
49	congestive heart failure	12.6	CCL2, ACE
50	morbid obesity	12.6	ACE, CCL2

Approved drugs:

Drug clinical trials:

Articles related to coronary artery disease, modifier of:

id	Title	Authors	Year	Affiliating Genes
1	The cardioprotective effects of the angiotensin-converting enzyme inhibitor perindopril in patients with stable coronary artery disease are not modified by mild to moderate renal insufficiency: insights from the EUROPA trial. (18036453)	Brugts J.J.... Simoons M.L.	2007	ACE

Genes related to coronary artery disease, modifier of according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CCL2	chemokine (C-C motif) ligand 2	11.0
2	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications

Pathways related to coronary artery disease, modifier of according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Renin-Angiotensin Pathway36	9.1	CCL2, ACE
2	Chagas disease (American trypanosomiasis)20	8.8	CCL2, ACE

Compounds related to coronary artery disease, modifier of according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	olmesartan32 9 9	11.4	ACE, CCL2
2	valsartan32 42 9 9	12.3	ACE, CCL2
3	irbesartan32 9 9	11.3	ACE, CCL2
4	telmisartan32 9 9	11.3	ACE, CCL2
5	candesartan32 9 9	11.2	ACE, CCL2
6	ang ii32	9.2	ACE, CCL2
7	losartan32 34 9 9	12.1	CCL2, ACE
8	norepinephrine32 9 18 9	12.1	CCL2, ACE
9	verapamil32 34 9 18 9	13.0	ACE, CCL2
10	prostacyclin32	8.8	ACE, CCL2