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MCID: CRN019
MIFTS: 42

Coronary Artery Vasospasm

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Coronary Artery Vasospasm

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MalaCards integrated aliases for Coronary Artery Vasospasm:

Name: Coronary Artery Vasospasm 12 14 69
Coronary Vasospasm 12 51 41
Coronary Artery Spasm 12 28

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11840
MeSH 41 D003329
NCIt 46 C34515
SNOMED-CT 64 23687008
UMLS 69 C0010073
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Summaries for Coronary Artery Vasospasm

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MalaCards based summary : Coronary Artery Vasospasm, also known as coronary vasospasm, is related to prinzmetal's variant angina and ischemia, and has symptoms including angina pectoris An important gene associated with Coronary Artery Vasospasm is EDN1 (Endothelin 1), and among its related pathways/superpathways are ACE Inhibitor Pathway, Pharmacodynamics and Calcium signaling pathway. The drugs Bisoprolol and Doxazosin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, testes and bone.

Wikipedia : 72 Coronary vasospasm is a sudden, intense vasoconstriction of an epicardial coronary artery that causes... more...

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Related Diseases for Coronary Artery Vasospasm

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Diseases related to Coronary Artery Vasospasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 prinzmetal's variant angina 32.7 EDN1 NOS3
2 ischemia 29.7 EDN1 KNG1 NOS3
3 chronic mountain sickness 10.3 EDN1 NOS3
4 acute chest syndrome 10.3 EDN1 NOS3
5 aortic coarctation 10.3 EDN1 NOS3
6 persistent fetal circulation syndrome 10.3 EDN1 NOS3
7 sexual disorder 10.3 EDN1 NOS3
8 hepatic vascular disease 10.3 EDN1 NOS3
9 chronic pulmonary heart disease 10.3 EDN1 HTR7
10 renovascular hypertension 10.3 EDN1 NOS3
11 malignant secondary hypertension 10.2 EDN1 KNG1
12 diffuse scleroderma 10.2 EDN1 KNG1
13 acute mountain sickness 10.2 EDN1 NOS3
14 ischemic optic neuropathy 10.2 EDN1 NOS3
15 hepatopulmonary syndrome 10.2 EDN1 NOS3
16 nonarteritic anterior ischemic optic neuropathy 10.2 EDN1 NOS3
17 renal hypertension 10.2 EDN1 KNG1
18 psychosexual disorder 10.2 HTR2A HTR7
19 apnea, obstructive sleep 10.1 EDN1 HTR2A
20 dysthymic disorder 10.1 HTR2A HTR7
21 limb ischemia 10.1 EDN1 NOS3
22 myocardial infarction 10.1
23 acute myocardial infarction 10.1
24 drug-induced mental disorder 10.1 HTR2A HTR7
25 drug psychosis 10.1 HTR2A HTR7
26 pulmonary edema 10.1 EDN1 NOS3
27 portal hypertension 10.0 EDN1 NOS3
28 ventricular fibrillation, paroxysmal familial, 1 10.0
29 acute myocarditis 10.0
30 myocarditis 10.0
31 impotence 10.0 EDN1 KNG1 NOS3
32 sleep apnea 10.0 EDN1 HTR2A NOS3
33 mental depression 10.0 HTR2A HTR7
34 arteries, anomalies of 10.0 EDN1 KNG1 NOS3
35 coronary artery anomaly 10.0 EDN1 KNG1 NOS3
36 vascular disease 9.9 EDN1 KNG1 NOS3
37 bulimia nervosa 1 9.9 HTR2A HTR7
38 osmotic diarrhea 9.9 HTR7 MGAM
39 pre-eclampsia 9.9 EDN1 KNG1 NOS3
40 graves disease 1 9.8
41 brugada syndrome 9.8
42 churg-strauss syndrome 9.8
43 thyroiditis 9.8
44 vasculitis 9.8
45 cantu syndrome 9.8 ABCC9 MGAM
46 orthostatic intolerance 9.7 EDN1 MGAM NOS3
47 perinephritis 9.7 EDN1 HTR7 MGAM
48 disease of mental health 9.6 HTR2A HTR7
49 hypertension, essential 9.4 EDN1 KNG1 MGAM NOS3

Graphical network of the top 20 diseases related to Coronary Artery Vasospasm:



Diseases related to Coronary Artery Vasospasm
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Symptoms & Phenotypes for Coronary Artery Vasospasm

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UMLS symptoms related to Coronary Artery Vasospasm:


angina pectoris
Sources

Drugs & Therapeutics for Coronary Artery Vasospasm

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Drugs for Coronary Artery Vasospasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bisoprolol Approved Phase 4 66722-44-9 2405
2
Doxazosin Approved Phase 4 74191-85-8 3157
3
Spironolactone Approved Phase 4,Phase 3 1952-01-7, 52-01-7 5833
4
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
5
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
6
Losartan Approved Phase 4 114798-26-4 3961
7
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
8
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
9
Oxytocin Approved, Vet_approved Phase 4 50-56-6 53477758 439302
10
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
11
Simvastatin Approved Phase 4 79902-63-9 54454
12
Amiloride Approved Phase 4 2609-46-3, 2016-88-8 16231
13
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
14
Ramipril Approved Phase 4 87333-19-5 5362129
15
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
16
Indapamide Approved Phase 4 26807-65-8 3702
17
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
18
Prazosin Approved Phase 4 19216-56-9 4893
19
Rilmenidine Approved, Investigational Phase 4 54187-04-1
20 Tocopherol Approved, Investigational, Nutraceutical Phase 4
21
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
22
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
23
Sarpogrelate Investigational Phase 4 125926-17-2 5160
24 Anticholesteremic Agents Phase 4,Phase 3
25 Antimetabolites Phase 4,Phase 3
26 Atorvastatin Calcium Phase 4,Phase 3 134523-03-8
27 Calcium, Dietary Phase 4,Phase 3,Phase 2
28 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3
29 Hypolipidemic Agents Phase 4,Phase 3
30 Lipid Regulating Agents Phase 4,Phase 3
31 Adrenergic Agents Phase 4,Early Phase 1
32 Adrenergic alpha-1 Receptor Antagonists Phase 4
33 Adrenergic alpha-Antagonists Phase 4
34 Adrenergic Antagonists Phase 4,Early Phase 1
35 Adrenergic beta-1 Receptor Antagonists Phase 4
36 Adrenergic beta-Antagonists Phase 4,Early Phase 1
37 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Autonomic Agents Phase 4,Phase 3,Phase 2
39 diuretics Phase 4,Phase 3,Early Phase 1
40 Diuretics, Potassium Sparing Phase 4,Phase 3
41 Hormone Antagonists Phase 4,Phase 3
42 Hormones Phase 4,Phase 3
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
44 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3
45 Mineralocorticoids Phase 4,Phase 3
46 Natriuretic Agents Phase 4,Phase 3,Early Phase 1
47 Neurotransmitter Agents Phase 4,Phase 3,Early Phase 1
48 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
49 Sympatholytics Phase 4
50 Angiotensin II Type 1 Receptor Blockers Phase 4

Interventional clinical trials:

(show top 50) (show all 72)

# Name Status NCT ID Phase Drugs
1 Efficacy Study of Atorvastatin to Treat Variant Angina Unknown status NCT00620204 Phase 4 atorvastatin
2 Optimum Treatment for Drug-Resistant Hypertension Unknown status NCT02369081 Phase 4 Spironolactone;Bisoprolol;Doxazosin;Placebo
3 Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension Unknown status NCT00994617 Phase 4 Losartan and hydrochlorothiazide;Hydrochlorothiazide switched over with Losartan at 8 weeks
4 Cardiac Effects of Oxytocin Administrated During Cesarean Section, Signs of Myocardial Ischemia Completed NCT00777166 Phase 4 oxytocin;oxytocin
5 Efficacy of Spironolactone in Cameroonian Diabetic Patients With Resistant Hypertension Completed NCT02426099 Phase 4 Low dose spironolactone
6 Carvedilol Post-intervention Long-term Administration in Large-scale Trial Completed NCT01155635 Phase 4 Carvedilol;No Carvedilol
7 ANti-Oxidant in Variant Angina (ANOVA) Trial Recruiting NCT03228238 Phase 4 Vitamin C and Vitamin E;Statin;Standard medication for variant angina
8 The Effect of Sarpogrelate and High Dose Statin on the Reduction of Coronary Spasm Recruiting NCT01674686 Phase 4 Sarpogrelate;Atorvastatin
9 Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death Recruiting NCT02845531 Phase 4 Optimal Medical Therapy
10 Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension Recruiting NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
11 Renal Denervation in Hypertension Active, not recruiting NCT01570777 Phase 4
12 BVS Implantation in Patients With Variant Angina and MODerate Coronary Artery Disease Enrolling by invitation NCT02932553 Phase 4
13 Effect of Amlodipine Versus Amlodipine Combined With Atorvastatin on the Coronary Vasospastic Angina Not yet recruiting NCT03054467 Phase 4 Caduet 10Mg-20Mg Tablet;NorvasC® 10 mg Tablets
14 Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA) Terminated NCT02539810 Phase 4 Anti hypertensive, statin and antiplatelet medication.
15 Statin Therapy In Patients With Vasospastic Angina Withdrawn NCT02790528 Phase 4 Atorvastatin;Placebo
16 Clopidogrel Versus Adenosin in Non Urgent Percutaneous Coronary Intervention (PCI) Unknown status NCT00751491 Phase 3 Adenosin;Clopidogrel
17 Continued Safety and Performance of the TIVUS System Unknown status NCT01835535 Phase 2, Phase 3
18 Safety and Efficacy Study of Cilostazol to Treat Vasospastic Angina Completed NCT02094469 Phase 3 Cilostazol
19 A Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of Cilostazol in Subjects With Vasospastic Angina Completed NCT02087007 Phase 3 Cilostazol;placebo
20 Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans Completed NCT01067339 Phase 3 darapladib;placebo
21 Rosuvastatin in Preventing Myonecrosis in Elective Percutaneous Coronary Interventions (PCIs) Completed NCT01007279 Phase 3 ROSUVASTATIN
22 ROsuvastatin Pretreatment to Reduce MyocArdial Periprocedural Necrosis:Comparison With Atorvastatin Reloading Completed NCT01228227 Phase 3 ATORVASTATIN 80 mg;ROSUVASTATIN 40 mg
23 The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant Hypertension Completed NCT01062763 Phase 3 spironolactone;placebo
24 Therapeutic Effect of Sildenafil in Patients With Coronary Vasospasm Withdrawn NCT00454714 Phase 3 single dose Sildenafil;Single dose placebo
25 Evaluate the Efficacy and Safety of Pletaal (Cilostazol) in Subjects With Vasospastic Angina Completed NCT01444885 Phase 2 Placebo
26 Addition of Homeopathy in Patients With Resistant Arterial Hypertension Completed NCT02124473 Phase 2
27 Rapid Renal Sympathetic Denervation for Resistant Hypertension Completed NCT01520506 Phase 2
28 Combined Treatment of Resistant Hypertension and Atrial Fibrillation Completed NCT01117025 Phase 2
29 Remote Ischaemic Conditioning and Coronary Endothelial Function (RIC-COR) Completed NCT02666235 Phase 2
30 Chemical Renal Ethanol Sympatholysis Under CT Guidance Use for the Control of Therapy-Resistant Hypertension Recruiting NCT02653222 Phase 2
31 Distal Renal Denervation Active, not recruiting NCT02667912 Phase 1, Phase 2
32 Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography Active, not recruiting NCT01673516 Phase 2
33 Safety and Efficacy Study of Extracorporeal Shockwave Therapy in the Treatment of Patients With Resistant Hypertension Unknown status NCT02042066 Phase 1
34 The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme Inhibitors Recruiting NCT02623036 Phase 1 Equivalent dose enalapril;Equivalent dose lisinopril
35 Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries Unknown status NCT01162824 Acetylcholine;Adenosine
36 Panic Disorder and Cardiac Risk Unknown status NCT00168506 SSRI;CBT;CBT/SSRI
37 Effect Baroreflex Activation Therapy on the Carotid Body Unknown status NCT02210923
38 Medication Adherence and "True" Resistance in Patients With Resistant Hypertension Unknown status NCT02128386
39 Resistant Hypertension and Physical Activity Performed in a Heated Pool Unknown status NCT01863082
40 Physical Activity Program for Reducing Blood Pressure in Sleep Apnea Patients With Resistant Hypertension Unknown status NCT02057783
41 CPAP Effect on Blood Pressure and Arterial Stiffness in Obstructive Sleep Apnea Patients With Resistant Hypertension Unknown status NCT02385864
42 Coronary Spasm Presenting Aborted Sudden Cardiac Death, the Multicenter Registry Completed NCT02298543
43 Endothelial Dysfunction and Coronary Artery Spasm Completed NCT00619294
44 The Prevalence of Coronary Spasm in Hypertensive Patients Treated With Antihypertensive Medication Completed NCT01882790
45 The Effect of Autonomic Function on Coronary Vasomotion Completed NCT01877993
46 Effect of Glucose on Ocular Blood Flow Completed NCT00350129
47 Uric Acid Levels and Endothelial Functions Completed NCT02862522
48 Bioequivalency Study of Amlodipine Tablets Under Fasting Conditions Completed NCT00602017 Amlodipine
49 Bioequivalency Study of Amlodipine Tablets Under Fed Conditions Completed NCT00601302 Amlodipine
50 Prevalence of Extracardiac Coronary Collateral Supply Via the Internal Mammary Arteries Completed NCT01676207

Search NIH Clinical Center for Coronary Artery Vasospasm

Cochrane evidence based reviews: coronary vasospasm

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Genetic Tests for Coronary Artery Vasospasm

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Genetic tests related to Coronary Artery Vasospasm:

# Genetic test Affiliating Genes
1 Coronary Artery Spasm 28
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Anatomical Context for Coronary Artery Vasospasm

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MalaCards organs/tissues related to Coronary Artery Vasospasm:

38
Endothelial, Testes, Bone, Heart, Brain, Thyroid
Sources

Publications for Coronary Artery Vasospasm

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Articles related to Coronary Artery Vasospasm:

(show top 50) (show all 51)
# Title Authors Year
1
Catastrophic catheter-induced coronary artery vasospasm successfully rescued using intravascular ultrasound imaging guidance. ( 29222206 )
2017
2
Case series of patients treated with the oral fluoropyrimidine S-1 after capecitabine-induced coronary artery vasospasm. ( 28623776 )
2017
3
Coronary-Artery Vasospasm. ( 28636863 )
2017
4
Outcomes of Brugada Syndrome Patients with Coronary Artery Vasospasm. ( 28090040 )
2017
5
Coronary Artery Vasospasm ( 29261899 )
2017
6
Capecitabine-induced coronary artery vasospasm in a patient who previously experienced a similar episode with fluorouracil therapy. ( 26875134 )
2016
7
Life Threatening Complication of Self-made Remedy for Controlling High Blood Pressure-Coronary Artery Vasospasm Associated with Iatrogenic Thyrotoxicosis. ( 27826349 )
2016
8
Coronary artery vasospasm during catheter cryoablation of left ventricular summit nonsustained ventricular tachycardia. ( 28491744 )
2016
9
IMAGES IN CLINICAL MEDICINE. Cocaine-Induced Coronary-Artery Vasospasm. ( 26840152 )
2016
10
Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease. ( 27396680 )
2016
11
Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig. ( 26806564 )
2016
12
Scombroid fish poisoning illness and coronary artery vasospasm. ( 25870660 )
2015
13
Unraveling of the Effect of Nodose Ganglion Degeneration on the Coronary Artery Vasospasm after Subarachnoid Hemorrhage; an Experimental Study. ( 26365883 )
2015
14
Organophosphate poisoning with coronary artery vasospasm confirmed by angiography. ( 25302727 )
2014
15
Patients with left main coronary artery vasospasm inadvertently undergoing coronary artery bypass grafting surgery. ( 23428222 )
2013
16
Amiodarone-induced destructive thyroiditis associated with coronary artery vasospasm and recurrent ventricular fibrillation. ( 24783040 )
2013
17
Capecitabine may induce coronary artery vasospasm. ( 22796820 )
2012
18
A case of caffeine-induced coronary artery vasospasm of a 17-year-old male. ( 22231478 )
2012
19
A Case of Acute Myocardial Infarction With ST-Segment Elevation in a Lead Augmented Right Vector Caused by a Left Main Coronary Artery Vasospasm. ( 22363384 )
2012
20
Intraoperative coronary artery vasospasm: a twist in the tale! ( 22435284 )
2011
21
Reversible ischemia on treadmill exercise in left main coronary artery vasospasm. ( 22340417 )
2011
22
Sorafenib-associated multivessel coronary artery vasospasm. ( 21584715 )
2011
23
A case report of 5-fluorouracil-induced coronary artery vasospasm. ( 22375089 )
2010
24
Coronary artery vasospasm and acute myocarditis: a rare association. ( 21428143 )
2010
25
Acute coronary artery vasospasm associated with misoprostol for termination of pregnancy. ( 20224253 )
2010
26
Coronary artery vasospasm. A sudden spasm of the coronary arteries can feel like a heart attack. ( 20583353 )
2010
27
Early recognition of catheter-induced left main coronary artery vasospasm: implications for revascularization. ( 20665882 )
2010
28
Multifocal severe coronary artery vasospasm mistaken for diffuse atherosclerosis: a case report. ( 20862333 )
2010
29
Rare manifestations of Churg-Strauss syndrome: coronary artery vasospasm, temporal artery vasculitis, and reversible monocular blindness-a case report. ( 19034601 )
2009
30
Coronary artery vasospasm causing ventricular fibrillation - an external loop recording. ( 19195763 )
2009
31
ST-segment elevation in lead augmented vector right may also be caused by diffuse left main coronary artery vasospasm without fixed stenosis. ( 18404728 )
2008
32
Coronary artery vasospasm or true transient left ventricular apical ballooning? Differentiation by nuclear imaging. ( 18674728 )
2008
33
Eosinophilia and coronary artery vasospasm. ( 18718813 )
2008
34
Coronary artery vasospasm during awake deep brain stimulation surgery. ( 18534972 )
2008
35
Coronary artery vasospasm with iron sucrose. ( 17327282 )
2007
36
Coronary artery vasospasm causing acute myocardial infarction in a heart transplant recipient. ( 15737767 )
2005
37
Coronary artery vasospasm during dobutamine stress echocardiography. ( 15891761 )
2005
38
5-flurouracil induced coronary artery vasospasm. ( 15020524 )
2004
39
Secondary coronary artery vasospasm promotes cardiomyopathy progression. ( 14982859 )
2004
40
Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP) channels. ( 12122112 )
2002
41
Acute myocardial infarction associated with myocardial bridge and coronary artery vasospasm. ( 12469991 )
2002
42
Amine metabolism: a novel path to coronary artery vasospasm. ( 11543647 )
2001
43
Use of exercise myocardial perfusion imaging to guide and assess the effectiveness of medical therapy in coronary artery vasospasm. ( 9588677 )
1998
44
Ephedrine-induced coronary artery vasospasm in a patient with prior cocaine use. ( 9085987 )
1997
45
Positron emission tomography with oxygen-15 of stunned myocardium caused by coronary artery vasospasm after recovery. ( 7888266 )
1995
46
Coronary artery vasospasm complicating acute myocarditis. A rare association. ( 3176473 )
1988
47
Observations on increased susceptibility to coronary artery vasospasm during beta blockade. ( 2886035 )
1987
48
The importance of excluding coronary artery vasospasm before percutaneous transluminal coronary angioplasty. A case report. ( 2946085 )
1986
49
Coronary artery vasospasm during treatment with intravenous nitroglycerin. ( 3930071 )
1985
50
Coronary artery vasospasm and emotional stress: a hypothetical link to atherosclerosis. ( 6270513 )
1981
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Variations for Coronary Artery Vasospasm

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Expression for Coronary Artery Vasospasm

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Search GEO for disease gene expression data for Coronary Artery Vasospasm.
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Pathways for Coronary Artery Vasospasm

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Pathways related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
ACE Inhibitor Pathway, Pharmacodynamics 57
Show member pathways
 11.22 KNG1 NOS3
2
Calcium signaling pathway 36
Show member pathways
 11.07 HTR2A HTR7 NOS3
3
HIF1Alpha Pathway 60
10.99 EDN1 NOS3
4
Endothelin Pathways 1
10.69 EDN1 NOS3
5
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 57
10.4 HTR2A HTR7
Sources

GO Terms for Coronary Artery Vasospasm

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Cellular components related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 HTR2A NOS3

Biological processes related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.85 EDN1 HTR2A HTR7 KNG1
2 response to drug GO:0042493 9.67 ABCC9 EDN1 HTR2A
3 regulation of blood pressure GO:0008217 9.54 EDN1 NOS3
4 positive regulation of MAP kinase activity GO:0043406 9.52 EDN1 HTR2A
5 sensory perception of pain GO:0019233 9.51 EDN1 HTR2A
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.5 EDN1 HTR2A KNG1
7 phosphatidylinositol 3-kinase signaling GO:0014065 9.48 EDN1 HTR2A
8 vasodilation GO:0042311 9.46 KNG1 NOS3
9 smooth muscle contraction GO:0006939 9.43 HTR2A HTR7
10 vasoconstriction GO:0042310 9.4 EDN1 HTR7
11 negative regulation of blood coagulation GO:0030195 9.37 EDN1 KNG1
12 negative regulation of potassium ion transport GO:0043267 9.26 HTR2A NOS3
13 artery smooth muscle contraction GO:0014824 9.16 EDN1 HTR2A
14 regulation of systemic arterial blood pressure by endothelin GO:0003100 8.96 EDN1 NOS3
15 regulation of blood vessel size GO:0050880 8.8 EDN1 KNG1 NOS3

Molecular functions related to Coronary Artery Vasospasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.16 HTR2A HTR7
2 G-protein coupled serotonin receptor activity GO:0004993 8.96 HTR2A HTR7
3 serotonin binding GO:0051378 8.62 HTR2A HTR7
Sources

Sources for Coronary Artery Vasospasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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