Coronary Heart Disease malady

MalaCards: Coronary Heart Disease, also known as coronary arteriosclerosis, is related to cholesterol and type 2 diabetes mellitus. An important gene associated with Coronary Heart Disease is CHDS9 (Coronary heart disease, suscpetibility to, 9), and among its related pathways are Metabolism of lipids and lipoproteins and Statin Pathway, Pharmacodynamics. The compounds fibrinogen and atp have been mentioned in the context of this disorder. Affiliated tissues include spleen, brain and spinal cord, and related mouse phenotypes are behavior/neurological and growth/size.

coronary heart disease 8 33 32 coronary arteriosclerosis 43

chd 26

Disease types for coronary heart disease family:

coronary heart disease 3	coronary heart disease 8
coronary heart disease 2	coronary heart disease 4
coronary heart disease 9	coronary heart disease 7
coronary heart disease 6

Diseases related to coronary heart disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 985)

id	Related Disease	Score	Top Affiliating Genes
1	cholesterol	48.3	ZNF568, ZNF202, PIK3C2A, LRP1, LRP5, COG2
2	type 2 diabetes mellitus	45.3	COG2, RETN, VWF, GCKR, GCG, SELE
3	diabetes mellitus	44.9	PIK3C2A, LRP5, COG2, RETN, CNDP1, VWF
4	obesity	44.7	PIK3C2A, LRP1, LRP5, COG2, RETN, VWF
5	hyperlipidemia	44.3	PIK3C2A, LRP1, COG2, RETN, VWF, PCSK9
6	coronary artery anomaly	43.9	PIK3C2A, LRP1, COG2, RETN, VWF, GCG
7	carcinoma	42.9	ZNF202, PIK3C2A, LRP1, LRP5, RETN, CNDP1
8	insulin resistance	42.9	LRP1, COG2, RETN, VWF, GCKR, GCG
9	hypercholesterolemia	42.6	PIK3C2A, LRP1, COG2, RETN, VWF, PCSK9
10	hypertriglyceridemia	42.0	LRP1, COG2, GCKR, SELE, SELP, SERPINE1
11	essential hypertension	39.7	COG2, RETN, VWF, SELE, SELL, SELP
12	acute myocardial infarction	39.1	PIK3C2A, COG2, RETN, KIF6, KIF2C, VWF
13	atherosclerosis	38.5	SELE, LCAT, CETP, MMP3, FABP12, ANGPTL3
14	homocysteine	38.5	PIK3C2A, COG2, RETN, VWF, GCG, SELE
15	thrombosis	38.3	PIK3C2A, LRP1, COG2, RETN, VWF, SELE
16	familial hypercholesterolemia	38.0	COG2, PCSK9, LPA, LPL, LIPC, LDLR
17	hypertension	37.8	GNB3, CYP11B2, NOS2, NOS3, ACE, AGT
18	arteriosclerosis	37.8	COG2, SELE, SELP, SERPINE1, LPA, LPL
19	ischemia	37.2	PIK3C2A, COG2, RETN, VWF, GCG, SELE
20	familial combined hyperlipidemia	36.8	COG2, LPL, LIPE, LIPC, USF1, LEPR
21	vascular disease	36.8	LRP1, RETN, VWF, SELE, SELP, SERPINC1
22	coronary arteriosclerosis	36.7	SELE, IL6, APOA1, APOB, APOE, CCL2
23	myocardial infarction	36.6	LGALS2, ESR1, TNFSF4, OLR1, LTA, ACE
24	alcoholism	36.6	GSR, IL1RN, GPT, HTR3A, ALDH2, AKR1A1
25	nephropathy	35.8	LRP1, COG2, RETN, CNDP1, VWF, GCG
26	ischemic heart disease	35.7	PIK3C2A, COG2, RETN, SELP, SERPINE1, LPA
27	hepatocellular carcinoma	35.5	CNDP1, VWF, SELE, SELP, SERPINC1, SERPINA6
28	hyperhomocysteinemia	34.9	VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
29	thrombophilia	34.8	VWF, SELE, SELP, SERPINC1, SERPINF2, SERPINE1
30	tangier disease	34.8	SELP, LPA, LPL, CLU, LCAT, CETP
31	hepatitis	34.4	SELP, SERPINA1, GSR, GPT, F2, ALB
32	apnea	34.2	RETN, VWF, SELE, SELP, SERPINE1, NAMPT
33	cetp deficiency	34.0	LPL, LIPC, SCARB1, LDLR, LCAT, CETP
34	prostatitis	34.0	PIK3C2A, LRP1, LRP5, RETN, KIF2C, VWF
35	periodontitis	33.8	MPO, CD36, CD14, MMP1, MMP3, MMP8
36	pneumonia	33.3	PIK3C2A, COG2, CNDP1, SELE, SELL, SERPINC1
37	neuronitis	33.3	PIK3C2A, LRP1, NCAN, RETN, CNDP1, VWF
38	proteinuria	33.3	PIK3C2A, COG2, VWF, SELL, SELP, SERPINC1
39	hyperglycemia	33.1	PIK3C2A, COG2, RETN, CNDP1, VWF, GCKR
40	twinning	32.9	LRP1, COG2, RETN, VWF, GCKR, GCG
41	aldosteronism	32.9	RETN, SERPINA6, SERPINE1, NAMPT, VEGFA, UTS2
42	thyroiditis	32.8	PIK3C2A, LRP1, COG2, RETN, VWF, GCG
43	carotid intimal medial thickness	32.8	SERPINE1, LPL, MTHFR, CETP, ITGB3, INS
44	lupus erythematosus	32.7	PIK3C2A, COG2, RETN, VWF, SELE, SELL
45	arterial calcification	32.6	VWF, SELE, BGLAP, KCNJ11, LEP, CETP
46	protein s deficiency	32.6	PIK3C2A, LRP1, SERPINC1, SERPINE1, LDLR, MTHFR
47	malaria	32.3	LRP1, KIF2C, VWF, SELE, SELP, SERPINC1
48	polycystic ovary syndrome	32.3	LEP, IRS1, INS, INSR, IGFBP1, IGF2
49	pulmonary disease	31.9	LRP5, RETN, VWF, SELE, SELL, SELP
50	systemic lupus erythematosus	31.8	VWF, SELE, VCAM1, CLU, LCN2, S100A8

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to coronary heart disease:

²²

MGI Mouse Phenotypes related to coronary heart disease:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	INF	LRP1, LRP5, SELE, SELP, SERPINA6, SEZ6L
2	growth/size phenotype	MP:0005378	16.8	PIK3C2A, LRP1, GCG, SELE, SELP, SERPINE1
3	immune system phenotype	MP:0005387	14.3	LRP1, LRP5, VWF, SELL, SELP, SELPLG
4	liver/biliary system phenotype	MP:0005370	13.2	LRP5, RETN, PCSK9, SERPINC1, SERPINA6, VEGFA
5	renal/urinary system phenotype	MP:0005367	12.5	SELP, SELPLG, SERPINA6, VAMP8, MYD88, CLU
6	cardiovascular system phenotype	MP:0005385	12.4	LRP1, LRP5, VWF, SELE, SELL, SELP
7	adipose tissue phenotype	MP:0005375	12.3	PIK3C2A, LRP1, RETN, SERPINE1, LPL, MYD88
8	respiratory system phenotype	MP:0005388	12.0	SELL, SELP, LPL, LEPR, UCP2, CD14
9	hematopoietic system phenotype	MP:0005397	11.5	VAMP8, MYD88, LCN2, CD28, CDKN2B, ITGA2
10	digestive/alimentary phenotype	MP:0005381	11.3	VWF, GCG, VEGFA, VAMP8, LIPE, LEP
11	limbs/digits/tail phenotype	MP:0005371	10.8	LRP5, VEGFA, LEP, CHKB, MTHFR, MMP14
12	cellular phenotype	MP:0005384	10.7	LRP5, VWF, SELE, SELL, SELP, SELPLG
13	skeleton phenotype	MP:0005390	10.5	LRP1, VEGFA, MYD88, KDR, LEP, LEPR
14	endocrine/exocrine gland phenotype	MP:0005379	10.3	LRP5, SELL, VAMP8, KCNJ11, LDLR, CDKN2B
15	embryogenesis phenotype	MP:0005380	10.3	LRP5, SERPINC1, SCARB1, BAZ1B, FDFT1, IL6ST
16	other phenotype	MP:0005395	10.2	CLU, KDR, LEPR, LDLR, MSR1, CDKN2A
17	integument phenotype	MP:0010771	9.9	SELP, SELPLG, LIPE, KCNJ11, LEPR, LDLR
18	vision/eye phenotype	MP:0005391	9.4	LRP5, SELE, SELP, SERPINC1, VEGFA, MYD88
19	reproductive system phenotype	MP:0005389	9.3	VEGFA, LIPE, LIPC, SCARB1, LEP, LEPR
20	muscle phenotype	MP:0005369	9.0	LRP1, VEGFA, LPL, LIPE, CLU, KDR
21	tumorigenesis	MP:0002006	7.9	SELL, SERPINE1, MYD88, LEP, LEPR, CDKN2B
22	no phenotypic analysis	MP:0003012	INF	SERPINA6, VEGFA, VCAM1, MYD88, LIPG, CLEC4A
23	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, LRP1, LRP5, RETN, VWF, PCSK9
24	mortality/aging	MP:0010768	INF	PIK3C2A, LRP1, LRP5, VWF, GCG, SELE
25	normal phenotype	MP:0002873	INF	LRP1, LRP5, SELE, VEGFA, , KDR
26	nervous system phenotype	MP:0003631	INF	LRP1, LRP5, VWF, SELP, SERPINC1, SEZ6L

Articles related to coronary heart disease:

(show top 50)    (show all 1090)

id	Title	Authors	Year	Affiliating Genes
1	Genetic variation of the ATP-binding cassette transpo rter A1 and susceptibility to coronary heart disease. (21300560)	Jiang Z.... Zhou Y.	2011	ABCA1
2	Common genetic variation in multiple metabolic pathwa ys influences susceptibility to low HDL-cholesterol and coronary heart disease. (20855565)	Peloso G.M.... Brousseau M.E.	2010	INSR, CTSD, LPL
3	Haplotype and genotype effects of the F7 gene on circ ulating factor VII, coagulation activation markers and incident coronary heart disease in UK men. (20735728)	Ken-Dror G.... Ireland H.A.	2010	F7
4	Role of BMI in the Association of the TCF7L2 rs790314 6 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. (20798759)	Kucharska-Newton A.M.... North K.E.	2010	TCF7L2
5	NT-proBNP is associated with coronary heart disease r isk in healthy older women but fails to enhance prediction beyond established r isk factors: results from the British Women's Heart and Health Study. (19815210)	Sattar N.... Lawlor D.A.	2010	NPPB
6	Multimarker prediction of coronary heart disease risk : the Women's Health Initiative. (20447530)	Kim H.C.... Robinson J.G.	2010	F8
7	Effect of statin therapy on leptin levels in patients with coronary heart disease. (20338208)	Sun Y.M.... Wang L.F.	2010	LEP, LSL
8	Genetic polymorphisms of glutathione S-transferase ge nes GSTM1, GSTT1 and risk of coronary heart disease. (20354063)	Wang J.... Xu Z.	2010	GSTT1, GSTM1
9	Insulin-resistance and metabolic syndrome in patient s with coronary heart disease defined by angiography (19435694)	Benozzi S.... Coniglio R.I.	2009	INS
10	Interleukin-10 concentration and coronary heart disease (CHD) event risk in the estrogen replacement and atherosclerosis (ERA) study. (17706223)	Lakoski S.G.... Herrington D.M.	2008	IL10
11	Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study. (18799872)	Morrison A.C.... Boerwinkle E.	2008	SERPINA9
12	A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. (18222354)	Shiffman D.... Ridker P.M.	2008	KIF6
13	The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, double-blind, placebo-controlled study. (18436114)	Mohler E.R.... Zalewski A.	2008	SELP
14	The role of mercury and cadmium heavy metals in vascu lar disease, hypertension, coronary heart disease, and myocardial infarction. (17405690)	Houston M.C.	2007	COMT
15	Cholesteryl ester transfer protein gene and coronary heart disease mortality: the Rotterdam study. (17767699)	Silva M.C.... Van Duijn C.M.	2007	CETP
16	Role of novel biomarkers of inflammation in patients with stable coronary heart disease. (17495262)	Oren H.... Cehreli S.	2007	CSF1
17	The C-480T hepatic lipase polymorphism is associated with HDL-C but not with risk of coronary heart disease. (16879193)	McCaskie P.A.... Beilby J.P.	2006	LIPC
18	Relation of depressive mood to plasminogen activator inhibitor, tissue plasminogen activator, and fibrinogen levels in patients with versus without coronary heart disease. (16635597)	Lahlou-Laforet K.... Consoli S.M.	2006	SERPINE1
19	Importance of blood cellular genomic profile in coronary heart disease. (16252156)	Baba M.I.... Grover A.	2006	LDLR, NR1H3
20	Salivary matrix metalloproteinase-8 in patients with and without coronary heart disease may indicate an increased susceptibility to periodontal disease. (16953826)	Furuholm J.... Meurman J.H.	2006	MMP8
21	Serum gamma-glutamyltransferase predicts non-fatal my ocardial infarction and fatal coronary heart disease among 28,838 middle-aged m en and women. (16772340)	Lee D.H.... Tuomilehto J.	2006	GGT1
22	Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women. (16906219)	Aberle J.... Seedorf U.	2006	PPARD
23	Relationship between interleukin-6 gene polymorphism and coronary heart disease and its effect on plasma lipid levels (16647016)	Wei Y.S.... Lan J.S.	2006	IL6
24	Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease. (15585208)	Abramson J.L.... Vaccarino V.	2005	CRP
25	Multidirectional effects of exercise of various type and intensity on lipid transport system of blood in healthy subjects and patie nts with coronary heart disease (16281489)	Aronov D.M.... Bondarenko I.Z.	2005	LPXN
26	Allelic variants of the human scavenger receptor class B type 1 and paraoxonase 1 on coronary heart disease: genotype-phenotype correlations. (15681296)	Rodriguez-Esparragon F.... Ferrario C.M.	2005	PON1, SCARB1
27	Insulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in Type 2 diabetic men with and without coronary heart disease. (15365613)	Wannamethee S.G.... Whincup P.H.	2004	INS
28	Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. (14641801)	Skogsberg J.... Ehrenborg E.	2003	PPARA, PPARD, COG2
29	Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease. (11911915)	Ozkan Y.... SimA9ek B.	2002	ALB
30	Treatment with atorvastatin to the National Cholesterol Educational Program goal versus 'usual' care in secondary coronary heart disease prevention. The GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study. (12201623)	Athyros V.G.... Kontopoulos A.G.	2002	COG2
31	Perindopril alters vascular angiotensin-converting enzyme, AT(1) receptor, and nitric oxide synthase expression in patients with coronary heart disease. (11882622)	Zhuo J.L.... Ohishi M.	2002	ACE, NOS2
32	Relation between insulin resistance and A1166C molecular variant of type 1 angiotensin II receptor gene in patients with coronary heart disease (12575209)	Deng J.... Huang D.	2002	INSR, AGTR1
33	Association of plasminogen activator inhibitor-1 gene 4G/5G polymorphism and coronary heart disease in Chinese patients (12362314)	Guan L.... Zhao L.	2002	SERPINE1
34	Association of apolipoprotein E gene polymorphism with early-onset coronary heart disease and its effect on plasma lipid levels (11592046)	Peng S.... Gong W.	2001	APOE
35	Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease. (11498464)	Kareinen A.... Laakso M.	2001	INS
36	Apolipoprotein E polymorphism in the early onset of coronary heart disease. (11780396)	Yang Z.... Ma W.	2001	APOE
37	Physician-prompting statin therapy intervention impro ves outcomes in patients with coronary heart disease. (11714215)	Hilleman D.E.... Amato C.M.	2001	HMGCR
38	Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. (11302007)	Nenseter M.S.... Ose L.	2000	PLAT, SELP
39	Identification and treatment of hypertriglyceridemia as a risk factor for coronary heart disease. (10980847)	Ginsberg H.N.	1999	HMGCR
40	An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E. (9760210)	Stengard J.H.... Sing C.F.	1998	APOE
41	The codon 55 polymorphism in the paraoxonase 1 gene is not associated with the risk of coronary heart disease in Asian Indians and Chinese. (9543091)	Sanghera D.K.... Kamboh M.I.	1998	PON1
42	Interethnic differences in coronary heart disease mortality in 25 populations: association with the angiotensin-converting enzyme DD genotype frequency. (9920000)	Young R.P.... Sanderson J.E.	1998	ACE
43	Apolipoprotein E as a risk factor for coronary heart disease: a genetic and molecular biology approach. (8743896)	de Knijff P.... Havekes L.M.	1996	APOE
44	Analysis of a new polymorphism in the human apolipoprotein A-I gene: association with serum lipoprotein levels and coronary heart disease. (8934336)	Bai H.... Arakawa K.	1996	APOA1
45	Sibling correlations of coronary heart disease risk factors in a sample of Israeli offspring with parental history of myocardial infarction. (7605365)	Friedlander Y.	1995	APOA1
46	Management of thrombosis in coronary heart disease. (7804737)	De Bono D.	1994	SERPINC1
47	Effects of sex hormones on plasma lipoproteins in middle older age non-diabetes, diabetes and coronary heart disease (8269788)	Yang W.Y.... Pan X.R.	1993	APOA1
48	Demonstration of a relationship between white blood cell count, insulin resistance, and several risk factors for coronary heart disease in women. (1402624)	Facchini F.... Reaven G.M.	1992	INS
49	Glucose tolerance, plasma insulin, HDL cholesterol an d obesity: 12-year follow-up and development of coronary heart disease in Edinb urgh men. (1632860)	Hargreaves A.D.... Riemersma R.A.	1992	INS
50	Lp(a) as a marker for coronary heart disease risk. (1828399)	Scanu A.M.	1991	APOB

Genes related to coronary heart disease according to GeneCards:

(show top 50)    (show all 415)

id	Symbol	Description	Score	GeneCards Section Context
1	CHDS9	Coronary heart disease, suscpetibility to, 9	11.1	Aliases & Descriptions
2	CHDS8	Coronary heart disease, susceptibility to, 8	11.1	Aliases & Descriptions
3	CHDS4	Coronary heart disease, susceptibility to, 4	11.1	Aliases & Descriptions
4	CHDS2	Coronary heart disease, susceptibility to, 2	11.1	Publications, Aliases & Descriptions
5	CHDS3	Coronary heart disease, susceptibility to, 3	11.1	Publications, Aliases & Descriptions
6	CHDS1	Coronary heart disease, susceptibility to, 1	11.1	Publications, Aliases & Descriptions
7	NPC1L1	NPC1 (Niemann-Pick disease, type C1, gene)-like 1	11.1	Summaries, Publications
8	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
9	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
10	PON2	paraoxonase 2	11.0	Functions, Publications
11	COG2	component of oligomeric golgi complex 2	11.0	Publications
12	PON1	paraoxonase 1	11.0	Publications, Functions
13	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
14	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
15	APOA4	apolipoprotein A-IV	11.0	Publications
16	APOC3	apolipoprotein C-III	11.0	Publications
17	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
18	CYBA	cytochrome b-245, alpha polypeptide	11.0	Publications
19	APOA1	apolipoprotein A-I	11.0	Publications
20	MGP	matrix Gla protein	11.0	Publications
21	APOA5	apolipoprotein A-V	11.0	Publications
22	PON3	paraoxonase 3	11.0	Publications
23	APOC1	apolipoprotein C-I	11.0	Publications
24	APOC2	apolipoprotein C-II	11.0	Publications
25	APOE	apolipoprotein E	11.0	Functions, Publications
26	SOAT2	sterol O-acyltransferase 2	11.0	Publications
27	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0	Publications
28	RETN	resistin	11.0	Publications
29	APOA2	apolipoprotein A-II	11.0	Publications
30	LIPG	lipase, endothelial	11.0	Publications
31	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	11.0	Publications
32	THBD	thrombomodulin	11.0	Publications
33	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications
34	VKORC1	vitamin K epoxide reductase complex, subunit 1	11.0	Publications
35	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
36	PLAT	plasminogen activator, tissue	11.0	Publications
37	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
38	ADRB3	adrenoceptor beta 3	11.0	Publications
39	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
40	FABP12	fatty acid binding protein 12	11.0	Publications
41	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
42	FABP2	fatty acid binding protein 2, intestinal	11.0	Publications
43	ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	11.0	Publications
44	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Publications
45	LIPC	lipase, hepatic	11.0	Publications
46	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
47	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
48	GDF15	growth differentiation factor 15	11.0	Publications
49	PROCR	protein C receptor, endothelial	11.0	Publications
50	PCSK9	proprotein convertase subtilisin/kexin type 9	11.0	Publications

Pathways related to coronary heart disease according to GeneDecks:

(show top 50)    (show all 86)

id	Pathway	Score	Top Affiliating Genes
1	Metabolism of lipids and lipoproteins38	13.0	LPL, LIPE, KDSR, SCAP, SCARB1, CHKA
2	Statin Pathway, Pharmacodynamics34	12.9	LRP1, LPL, LIPC, SCARB1, LDLR, LCAT
3	PPAR signaling pathway20	12.5	LPL, CD36, MMP1, APOA1, APOA2, APOA5
4	Fat digestion and absorption20	12.2	SCARB1, MTTP, CEL, CD36, APOA1, APOA4
5	Complement and coagulation cascades20	12.1	VWF, SERPINC1, SERPINF2, SERPINA1, SERPINE1, CFB
6	Selected targets of HNF110	11.8	SERPINA1, LPA, UCP2, INS, APOA1, APOA2
7	Blood Coagulation Signaling Pathways37	11.7	VWF, SERPINC1, SERPINF2, SERPINE1, FGB, GP1BA
8	Transendothelial Migration of Leukocytes36	11.5	VCAM1, ITGA2, ITGA2B, ITGAL, ITGAM, ITGB3
9	Phagosome20	11.4	SCARB1, MSR1, MPO, CD36, CD14, ITGA2
10	Selected targets of C/EBPalpha10	11.3	RETN, SERPINC1, CETP, CD36, MMP8, APOB
11	Extrinsic Prothrombin Activation Pathway36	11.3	SERPINC1, FGA, FGB, F7, F5, F2
12	Blood Coagulation Cascade36	11.1	SERPINC1, FGA, FGB, F9, F8, F7
13	Akt Signaling36	11.1	UTS2, CD28, ITGA2, ITGA2B, ITGAL, ITGAM
14	Staphylococcus aureus infection20	11.1	SELP, SELPLG, CFB, CFD, CFH, ITGAL
15	ACE Inhibitor Pathway, Pharmacodynamics34	11.0	CMA1, CTSG, ACE2, AGTR1, AGTR2
16	Hematopoietic cell lineage20	11.0	CD36, CD14, CD59, ITGA2, ITGA2B, ITGAM
17	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.9	CMA1, CYP11B2, CTSG, NOS3, ACE, ACE2
18	RAR-Gamma-RXR-Alpha Degradation36	10.8	IL15, IL7, CCL11, CCL3, RXRA, PF4
19	PPAR Pathway36	10.8	UTS2, ITGA2, ITGA2B, ITGAL, ITGAM, ITGB3
20	Selected targets of GCR-alpha10	10.8	LEP, UCP3, INS, INSR, IL1B, IL4
21	STAT3 Pathway36	10.7	CD28, IL10, IL15, IL18, IL18R1, IL1A
22	Molecular Mechanisms of Cancer36	10.7	LRP5, UTS2, KDR, CDKN2B, CDKN2A, ITGA2
23	MIF Mediated Glucocorticoid Regulation36	10.7	CD14, MIF, IL10, IL15, IL18, IL1A
24	PEDF Induced Signaling36	10.6	IL10, IL15, IL18, IL1A, IL1B, IL4
25	MIF Regulation of Innate Immune Cells36	10.6	CD14, MIF, IL10, IL15, IL18, IL1A
26	Malaria20	10.6	LRP1, SELE, SELP, VCAM1, MYD88, CD36
27	Endothelin-1 Signaling Pathway36	10.5	FLT1, INSR, IL10, IL18, IL1A, IL1B
28	LDL Oxidation in Atherogenesis36	10.4	VCAM1, MSR1, MPO, CD36, IL1B, CCL2
29	IL-6 Pathway36	10.4	IL10, IL15, IL18, IL1A, IL1B, IL4
30	all-trans-Retinoic Acid Signaling in Brain36	10.3	IL10, IL15, IL18, IL1A, IL1B, IL4
31	Activation of Matrix Metalloproteinases38	10.1	CMA1, MMP1, MMP14, MMP2, MMP3, MMP8
32	PGC1Alpha Pathway36	10.1	INSR, IL15, IL18, IL1A, IL1B, IL1R1
33	Tec Kinases Signaling36	10.0	MYD88, UTS2, CD28, ITGA2, ITGA2B, ITGAL
34	MSP-RON Signaling36	9.8	ITGAM, IL18, IL1B, CCR2, CCL2, IFNG
35	Tuberculosis20	9.8	MYD88, CD14, ITGAM, FCGR2A, IL10, IL18
36	ERK Signaling36	9.7	UTS2, ITGA2B, ITGAL, ITGAM, FN1, FLT1
37	Antioxidant Action of Vitamin-C36	9.5	UTS2, KDR, CD28, FLT1, FGF2, IL10
38	Rho Family GTPases36	9.3	UTS2, KDR, ITGA2, ITGA2B, ITGAL, ITGAM
39	p38 Signaling36	9.3	UTS2, KDR, CD28, FLT1, INSR, FGF2
40	NF-KappaB (p50-p65) Pathway36	9.2	MYD88, UTS2, KDR, FLT1, FGF2, IL1A
41	Chagas disease (American trypanosomiasis)20	9.2	SERPINE1, MYD88, IL10, IL1B, IL6, IL8
42	Cytokine-cytokine receptor interaction20	9.2	VEGFA, KDR, LEP, LEPR, CD40LG, FLT1
43	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.1	BGLAP, IL1A, IL1B, IL6, APOE, IGF1
44	Rheumatoid arthritis20	9.1	VEGFA, CD28, ITGAL, MMP1, MMP3, FLT1
45	Leishmaniasis20	9.1	MYD88, ITGAM, FCGR2A, IL10, IL1A, IL1B
46	PAK Pathway36	9.0	UTS2, KDR, FLT1, FGF2, IL10, IL15
47	MAPK Family Pathway36	8.9	UTS2, KDR, FLT1, FGF2, IL10, IL15
48	NF-KappaB Family Pathway36	8.8	MYD88, UTS2, KDR, FLT1, FGF2, IL1A
49	TGF-Beta Pathway36	8.6	UTS2, KDR, FLT1, FGF2, IL10, IL15
50	JAK-STAT Pathway36	8.2	UTS2, KDR, FLT1, INSR, FGF2, IL10

Compounds related to coronary heart disease according to GeneDecks:

(show top 50)    (show all 544)

id	Compound	Score	Top Affiliating Genes
1	fibrinogen32	16.9	PIK3C2A, COG2, RETN, SELE, SELP, SELPLG
2	atp32	15.0	ZNF202, PIK3C2A, KIF2C, MYD88, LIPC, CLU
3	alanine32	14.9	PIK3C2A, COG2, RETN, VWF, GCG, SELE
4	arginine32	13.9	PIK3C2A, COG2, VWF, GCG, SERPINC1, SERPINF2
5	fenofibrate32 9 9	15.7	PIK3C2A, COG2, RETN, SELE, SELP, SERPINE1
6	heparin32 9 18 9	16.7	PIK3C2A, LRP1, COG2, VWF, GCG, SELPLG
7	hydrogen32 18	14.7	PCSK9, SELPLG, CHKB, UCP2, UCP3, MTR
8	oxygen32 18	14.3	PIK3C2A, SELPLG, SERPINF2, SERPINA1, UTS2, LIPG
9	ethanol32 34 9 18 9	16.9	SERPINA1, LPA, LIPE, LIPC, CLU, LEPR
10	bezafibrate32 9 9	14.9	PIK3C2A, COG2, SERPINE1, LPA, LPL, LIPC
11	glycogen32 18	13.8	PIK3C2A, LRP1, RETN, GCKR, GCG, LIPE
12	dexamethasone32 42 34 9 9	16.4	LRP1, RETN, VWF, SELL, SELP, SELPLG
13	glycerol32 9 18 9	15.2	PIK3C2A, VWF, GCG, SERPINC1, LPL, LIPE
14	thiazolidinedione32	12.0	RETN, SERPINE1, LPL, SCARB1, LEP, UCP2
15	lysine32	12.0	SERPINF2, SERPINA1, PAPPA, KCNJ11, CHKA, CHKB
16	acetylcholine32 9 18 9	14.6	PIK3C2A, VWF, GCG, LPL, UTS2, KCNJ5
17	c-peptide32	11.5	RETN, GCG, KCNJ11, LEP, IRS1, INSR
18	cocaine32 9 9	13.5	PIK3C2A, GCG, SELE, SELP, VCAM1, LEP
19	streptozotocin32	11.4	GCG, LPL, KDR, LDLR, UCP2, CETP
20	vitamin b1232	11.3	VWF, LPA, MTHFR, MTR, MPO, CD79A
21	vitamin d32	11.3	LRP1, LRP5, SERPINE1, LPL, CLU, BGLAP
22	glutamate32	11.3	GCG, VKORC1, CLU, KDR, KCNJ11, KCNJ5
23	sodium dodecylsulfate32	11.3	LRP1, VWF, SERPINF2, SERPINE1, LPA, LPL
24	prostaglandin32	11.2	KCNJ5, UCP2, MMP1, MMP3, MMP9, IL18R1
25	guanidine hydrochloride32	11.1	VWF, LPL, BGLAP, CHKB, FN1, MGAM
26	manganese superoxide32	11.1	VCAM1, UCP2, MTTP, CD14, GSR, GSTM1
27	dextran sulfate32	11.1	SELE, SELL, SELP, SERPINC1, LPL, LDLR
28	perindopril32 34 9 9	14.1	VWF, SERPINE1, VEGFA, ALB, CRP, PLAT
29	cuprophan32	10.9	SELL, SELP, SERPINF2, VCAM1, CD14, ITGAL
30	verapamil32 34 9 18 9	14.9	LRP1, UTS2, KCNJ11, LDLR, MTTP, INSR
31	irbesartan32 9 9	12.8	COG2, SERPINE1, MMP9, CCL2, ALB, PTGS1
32	progestin32	10.8	SERPINC1, VEGFA, PAPPA, KDR, INSR, APOA1
33	12-o-tetradecanoylphorbol 13-acetate32	10.7	MSR1, ITGA2, ITGA2B, ITGAM, MMP14, MMP2
34	cyclosporin a32 42	11.3	PIK3C2A, COG2, VWF, SELP, LPL, LIPC
35	propranolol32 34 9 18 9	14.3	LIPE, LDLR, MPO, ITGAL, MMP2, APP
36	acetaldehyde32 18	11.3	LCAT, CETP, FN1, IL10, IL4, APOA1
37	lipoteichoic acid32	10.2	SELE, MYD88, SCARB1, CD14, IL10, IL18
38	4-hydroxynonenal32 18	11.2	CHKA, UCP2, UCP3, LCAT, MPO, MMP1
39	procollagen32	10.0	CMA1, BGLAP, CD36, MMP1, MMP14, MMP2
40	prednisolone32 9 9	11.8	PIK3C2A, VWF, SELL, SERPINA6, VCAM1, BGLAP
41	ns 39832 42	10.6	BGLAP, MMP1, FGF2, IL1A, IL1B, IL8
42	15-deoxy-delta-12,14-prostaglandin j232	9.4	SERPINE1, VEGFA, VCAM1, CD36, FGF2, IL10
43	curcumin32	9.2	VEGFA, VCAM1, UGT1A1, LDLR, MMP1, MMP14
44	doxorubicin32 34 9 9	12.1	PIK3C2A, SELE, CLU, KDR, CHKA, CD40LG
45	thalidomide32 42 9 9	12.1	SELL, VEGFA, KDR, CD36, CD40LG, FGF2
46	il 1032	8.9	IL10, IL15, IL18, IL1A, IL1B, IL1R1
47	paclitaxel32 34 9 9	10.8	VEGFA, CLU, KDR, CDKN2A, MMP1, FN1
48	chloramphenicol32 9 9	INF	SELE, SERPINC1, SERPINE1, LPL, , UGT1A1
49	leucine32	INF	LRP1, COG2, LPA, , KCNJ11, SCARB1
50	cholesterol32 9 18 9	INF	ZNF202, PIK3C2A, LRP1, LRP5, COG2, RETN

Cellular components related to coronary heart disease according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	14.2	ABCB11, PROC, CX3CL1, CXCL16, CXCR3, CXCR4
2	extracellular region	GO:005576	13.4	IGF1, CTSS, CTSG, CTSL1, PPBP, NRG1
3	high-density lipoprotein particle	GO:034364	12.3	LIPC, LCAT, SAA1, SAA4, CETP, APOA1
4	extracellular space	GO:005615	12.3	PCSK9, GCG, TGFB3, LTA, PF4, PLA2G2A
5	integral to plasma membrane	GO:005887	12.2	CD40LG, ITGA2B, ITGB3, MMP14, FOLH1, FLT1
6	very-low-density lipoprotein particle	GO:034361	11.5	APOL1, APOM, APOE, APOC4, VIMP, LPL
7	chylomicron	GO:042627	11.4	APOE, LPL, APOA2, APOA4, APOA5, APOB
8	cell surface	GO:009986	11.2	APP, CXCR4, SORT1, ADAMTS13, CX3CL1, PVRL2
9	spherical high-density lipoprotein particle	GO:034366	10.9	APOA2, APOA1, CLU, APOC3, APOM, PON1
10	secretory granule	GO:030141	10.9	APOA1, HSPD1, GCG, TF, ELANE, AVP
11	low-density lipoprotein particle	GO:034362	10.8	PLA2G7, VIMP, APOM, APOF, APOE, LDLR
12	platelet alpha granule lumen	GO:031093	10.6	VWF, SERPINF2, SERPINA1, SERPINE1, VEGFA, CLU
13	external side of plasma membrane	GO:009897	10.4	VWF, SELL, SELP, VCAM1, KDR, KCNJ5
14	caveola	GO:005901	10.2	SELE, NOS3, IRS1, PTGS2, HMOX1, CAV1

Biological processes related to coronary heart disease according to GeneDecks:

(show top 50)    (show all 84)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	14.7	PIK3C2A, NCAN, GCKR, GCG, NAMPT, LPA
2	lipid metabolic process	GO:006629	13.6	ZNF202, LPA, LPL, LIPG, LIPE, CLU
3	cholesterol homeostasis	GO:042632	13.4	LRP5, PCSK9, LIPG, LIPC, SCARB1, LDLR
4	lipoprotein metabolic process	GO:042157	13.2	PCSK9, LPA, LPL, SCARB1, LDLR, LCAT
5	blood coagulation	GO:007596	13.0	KIF2C, VWF, SELL, SELP, SELPLG, SERPINC1
6	cholesterol metabolic process	GO:008203	12.5	PCSK9, LIPE, LIPC, SCAP, LEP, LEPR
7	reverse cholesterol transport	GO:043691	12.4	LIPG, LIPC, CLU, SCARB1, LCAT, CETP
8	triglyceride homeostasis	GO:070328	12.2	GCKR, LPL, LIPC, SCARB1, CETP, MLXIPL
9	high-density lipoprotein particle remodeling	GO:034375	12.2	LIPG, LIPC, SCARB1, LCAT, CETP, APOA1
10	cholesterol efflux	GO:033344	12.2	SCARB1, APOA1, APOA2, APOA4, APOC1, APOC2
11	platelet activation	GO:030168	12.2	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
12	proteolysis	GO:006508	11.9	CNDP1, LPA, CMA1, PAPPA, CFB, CFD
13	cholesterol transport	GO:030301	11.6	LDLR, LCAT, CETP, MSR1, CD36, APOA1
14	positive regulation of macrophage derived foam cell differentiation	GO:010744	11.6	LPL, MSR1, CD36, APOB, PLA2G10, PLA2G2A
15	triglyceride metabolic process	GO:006641	11.5	PCSK9, LPL, CEL, CETP, INSIG1, INSIG2
16	platelet degranulation	GO:002576	11.5	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
17	low-density lipoprotein particle remodeling	GO:034374	11.5	LIPC, CETP, MPO, APOA2, APOB, PLA2G7
18	positive regulation of inflammatory response	GO:050729	11.4	SERPINE1, IL15, IL18, CCR2, CCL3, TNFRSF1A
19	acute-phase response	GO:006953	11.3	SERPINF2, SERPINA1, SAA1, SAA4, CD163, FN1
20	leukocyte migration	GO:050900	11.3	SELL, SELP, SELPLG, ITGAL, ITGAM, ITGB3
21	positive regulation of interleukin-6 production	GO:032755	11.3	MYD88, CD36, IL1A, IL1B, IL6, IL6R
22	innate immune response	GO:045087	11.3	MYD88, CLU, CLEC4A, LCN2, CFB, CFD
23	response to lipopolysaccharide	GO:032496	11.2	SELE, SELP, SERPINA1, UGT1A1, S100A8, MMP9
24	aging	GO:007568	11.1	VCAM1, SCAP, UCP3, GSN, IL15, IL1B
25	negative regulation of apoptotic process	GO:043066	11.1	GCG, SERPINE1, VEGFA, CLU, KDR, LEP
26	negative regulation of macrophage derived foam cell differentiation	GO:010745	11.1	CETP, ITGB3, PPARG, PPARA, NR1H2, NR1H3
27	positive regulation of MAPK cascade	GO:043410	10.9	KDR, LEP, CD36, FLT1, INS, INSR
28	cell surface receptor signaling pathway	GO:007166	10.9	MYD88, CLEC4A, LEPR, CD28, CD36, CD14
29	response to nutrient	GO:007584	10.9	SERPINC1, VCAM1, LIPG, UGT1A1, UCP3, MGP
30	inflammatory response	GO:006954	10.9	SELE, SELP, MYD88, S100A8, CD14, CD40LG
31	response to glucocorticoid stimulus	GO:051384	10.8	SERPINE1, BGLAP, UCP3, LCAT, INSR, IL10
32	xenobiotic metabolic process	GO:006805	10.8	UGT1A1, MTR, GSTM1, GSTM4, GSTM5, ALDH2
33	positive regulation of vasodilation	GO:045909	10.8	UTS2, INS, CALCA, HMOX1, NOS1, NOS3
34	positive regulation of cellular protein metabolic process	GO:032270	10.7	INS, NR1H2, NR1H3, PLA2G10, AGT, AGTR1
35	regulation of blood pressure	GO:008217	10.6	LRP5, UTS2, LEP, GNB3, CALCA, HMOX1
36	response to ethanol	GO:045471	10.5	BGLAP, S100A8, AVP, MMP9, INSR, GSN
37	response to drug	GO:042493	10.4	LPL, UTS2, LIPE, BGLAP, KCNJ11, UGT1A1
38	wound healing	GO:042060	10.4	SCARB1, S100A8, ITGB3, MIA3, INS, FGF2
39	negative regulation of smooth muscle cell proliferation	GO:048662	10.3	IL15, APOD, IGFBP5, IGFBP3, IFNG, HMOX1
40	positive regulation of angiogenesis	GO:045766	10.3	SERPINE1, VEGFA, UTS2, KDR, MMP9, FLT1
41	positive regulation of cell proliferation	GO:008284	10.3	LRP5, NAMPT, VEGFA, KDR, LEP, AVP
42	positive regulation of tumor necrosis factor production	GO:032760	10.2	MYD88, CD36, CD14, IL18, CCL3, IFNG
43	lipopolysaccharide-mediated signaling pathway	GO:031663	10.1	MYD88, SCARB1, IL18, IL1B, CCL2, CCL3
44	negative regulation of growth of symbiont in host	GO:044130	9.9	MYD88, CD36, IL10, MBL2, IFNG, TNF
45	positive regulation of cell migration	GO:030335	9.9	VEGFA, KDR, CDH13, MMP14, IRS1, FLT1
46	cellular response to lipopolysaccharide	GO:071222	9.7	SERPINE1, VIMP, CD36, CD14, IL10, IL8
47	positive regulation of smooth muscle cell proliferation	GO:048661	9.6	SERPINF2, MYD88, CDH13, FLT1, IL6, IL6R
48	positive regulation of nitric oxide biosynthetic process	GO:045429	9.4	INS, INSR, IL1B, IFNG, ICAM1, ESR1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	LRP5, SERPINF2, SERPINE1, VEGFA, MYD88,
50	response to hypoxia	GO:001666	INF	SERPINA1, VEGFA, VCAM1, UTS2, , SCAP

Molecular functions related to coronary heart disease according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol binding	GO:015485	11.8	APOA1, CRP, APOC3, APOD, APOF, CAV1
2	lipid transporter activity	GO:005319	11.6	APOC4, MTTP, CETP, APOA2, APOA4, APOD
3	cholesterol transporter activity	GO:017127	11.4	ABCG8, APOA4, APOA2, APOA1, CETP, ABCA1
4	heparin binding	GO:008201	11.2	SELL, SELP, SERPINC1, VEGFA, LPA, LPL
5	lipid binding	GO:008289	11.2	PPARD, PLTP, APOE, PTGS1, PPARA, PTGS2
6	serine-type endopeptidase activity	GO:004252	11.0	PROC, F12, CTSG, PLAT, KLK3, KLKB1
7	hormone activity	GO:005179	11.0	NPPC, ADIPOQ, UTS2, INS, IGF2, IGF1
8	protease binding	GO:002020	11.0	SERPINE1, SERPINA1, SERPINF2, TNF, INS, IL1R1
9	eukaryotic cell surface binding	GO:043499	10.7	TGFB1, THBS1, MBL2, APOA4, ADIPOQ, SELP
10	low-density lipoprotein particle binding	GO:030169	10.6	THBS1, CDH13, CRP, CD36, MSR1, SCARB1
11	receptor binding	GO:005102	10.6	APOF, FGL1, FGB, FGA, MIF, AVP
12	steroid hormone receptor activity	GO:003707	10.3	NR1H3, THRA, RXRB, RXRA, PPARA, ESR1
13	growth factor activity	GO:008083	9.6	IGF2, IL6, IL4, IL1B, IL10, FGF2
14	heme binding	GO:020037	9.6	CYP2J2, NOS1, NOS2, NOS3, FADS2, PTGS1
15	cytokine activity	GO:005125	9.2	TNFSF4, NRG1, LTA, EDN1, CSF1, ADIPOQ
16	protein heterodimerization activity	GO:046982	INF	ADRB1, VEGFA, , ADD1, CYBA, EXT2
17	protein binding	GO:005515	INF	NR1H2, RXRA, RXRB, PDZK1, KLK3, KLKB1
18	protein homodimerization activity	GO:042803	INF	UGT1A1, CCR2, ALOX5AP, CBS, CAT, EXT2
19	enzyme binding	GO:019899	INF	ALOX5AP, PTGS2, TGFB1, APOB, HMOX1, APOA5