MCID: CRN030
MIFTS: 43

Coronary Stenosis malady

Cardiovascular diseases category
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Summaries for Coronary Stenosis

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MalaCards based summary: Coronary Stenosis, also known as coronary artery stenosis, is related to ischemia and acute myocardial infarction. An important gene associated with Coronary Stenosis is OLR1 (oxidized low density lipoprotein (lectin-like) receptor 1), and among its related pathways are Cell surface interactions at the vascular wall and Selected targets of C EBPbeta. The compounds fucoidan and pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related mouse phenotype immune system.

Aliases & Classifications for Coronary Stenosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH
See all sources

Coronary Stenosis, Aliases & Descriptions:

Name: Coronary Stenosis 8 10 44 62
 
Coronary Artery Stenosis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:4248
NCIt39 C80427
SNOMED-CT57 233970002
MeSH34 D023921

Related Diseases for Coronary Stenosis

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Diseases related to Coronary Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.6PECAM1, OLR1, FGA
2acute myocardial infarction30.4OLR1, SOD3, PECAM1, FGA
3insulin resistance30.1SOD3, CETP, CCL11
4myocardial infarction29.8SOD3, FGA, OLR1, PECAM1, CETP, CCL11
5hypercholesterolemia29.8FGA, CETP, OLR1
6pneumonia29.7SOD3, CCL11, FGA
7atherosclerosis29.5OLR1, CETP, CCL11, FGA, SOD3, PECAM1
8diabetes mellitus29.5PECAM1, CETP, OLR1, FGA
9artery disease10.6
10angina pectoris10.5
11takayasu's arteritis10.4
12kawasaki disease10.4
13endotheliitis10.4
14relapsing polychondritis10.3
15hyperphosphatemia10.3
16cardiogenic shock10.3
17mediastinitis10.3
18aneurysm10.3
19hypertension10.2
20familial hyperlipidemia10.2OLR1, CETP
21cerebrovascular disease10.2CETP, SOD3
22williams-beuren syndrome10.2
23subendocardial myocardial infarction10.2
24coronary aneurysm10.2
25periodontitis10.2
26pulmonary embolism10.2
27coronary artery aneurysm10.2
28syncope10.2
29hypertrophic cardiomyopathy10.2
30vascular disease10.1SOD3
31congenital heart disease10.1CETP, SOD3
32food allergy10.1CETP, CCL11
33chronic obstructive pulmonary disease10.1CCL11, SOD3
34crohn's disease10.0
35familial hypercholesterolemia10.0
36ischemic heart disease10.0
37neutropenia10.0
38non-hodgkin lymphoma10.0
39obesity10.0
40type 2 diabetes mellitus10.0
41pseudoxanthoma elasticum10.0
42abdominal aortic aneurysm10.0
43supravalvular aortic stenosis10.0
44aortitis10.0
45moyamoya disease10.0
46myocardial stunning10.0
47churg-strauss syndrome10.0
48cerebritis10.0
49aortic aneurysm10.0
50aortic valve stenosis10.0

Graphical network of the top 20 diseases related to Coronary Stenosis:



Diseases related to coronary stenosis

Symptoms for Coronary Stenosis

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Drugs & Therapeutics for Coronary Stenosis

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Drug clinical trials:

Search ClinicalTrials for Coronary Stenosis

Search NIH Clinical Center for Coronary Stenosis

Genetic Tests for Coronary Stenosis

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Anatomical Context for Coronary Stenosis

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MalaCards organs/tissues related to Coronary Stenosis:

32
Heart, Testes, Endothelial, Brain, Bone marrow, Bone, Liver, Monocytes, Neutrophil

Animal Models for Coronary Stenosis or affiliated genes

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MGI Mouse Phenotypes related to Coronary Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6FGA, OLR1, CCL11, SOD3, PECAM1

Publications for Coronary Stenosis

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Articles related to Coronary Stenosis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Fractional flow reserve or optical coherence tomography guidance to revascularize intermediate coronary stenosis using angioplasty (FORZA) trial: study protocol for a randomized controlled trial. (24758510)
2014
2
Shoulder technique: A modified sleeve technique devised for treating isolated coronary stenosis at side branch ostium. (24342408)
2014
3
Non-contrast 1.5T FIESTA magnetic resonance angiography and 64-multidetector computed tomographic angiography have a similar accuracy for the detection of proximal coronary stenosis. (23706328)
2013
4
Side branch ostium stenting with main vessel drug-eluting balloon kissing (BOMB): an innovative approach for isolated coronary stenosis at side branch ostium. (23907034)
2013
5
Beyond Coronary Stenosis: Coronary Computed Tomographic Angiography for the Assessment of Atherosclerotic Plaque Burden. (23524381)
2013
6
Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters. (24368093)
2013
7
Visceral adipose tissue area is associated with coronary stenosis and noncalcified plaques. (23748189)
2013
8
Propensity score matched lesion-based comparison of long-term clinical and angiographic outcomes after placement of sirolimus (Cypher Bx Velocity) and paclitaxel (TAXUS Express)-eluting stents for de novo native coronary stenosis. (24122399)
2013
9
Dual-source computed tomography for evaluating coronary stenosis and left ventricular function. (24137298)
2013
10
The exercise treadmill test: predictors of true presence of significant coronary stenosis in patients with severe ST-segment depression. (22870737)
2012
11
Angina without significant coronary stenosis of non vasospastic origin. Clinical profile and long-term follow-up of patients with vs patients without stress induced ST segment depression. (22748501)
2012
12
Incremental value of myocardial perfusion over regional left ventricular function and coronary stenosis by cardiac CT for the detection of acute coronary syndromes in high-risk patients: a subgroup analysis of the ROMICAT trial. (22146497)
2011
13
The case of disappearing coronary stenosis. (21180043)
2010
14
Power changes with treatment of coronary stenosis in a highly trained cyclist. (20606521)
2010
15
Left main coronary stenosis as a consequence of bentall operation: percutaneous treatment. (19946628)
2009
16
Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US. (19130178)
2009
17
Surgery, not percutaneous revascularization, is the preferred strategy for patients with significant left main coronary stenosis. (19237672)
2009
18
What coronary stenosis needs PCI/stent? (17680615)
2007
19
Attenuation of heart failure due to coronary stenosis by ACE inhibitor and angiotensin receptor blocker. (12649073)
2003
20
Impact of diabetes on coronary stenosis and coronary artery calcification detected by electron-beam computed tomography in symptomatic patients. (11919127)
2002
21
Transesophageal echocardiographic assessment of coronary stenosis: a decade of experience. (11182783)
2001
22
A comparison of quantitative coronary angiography systems using a unique set of in vivo coronary stenosis images. (11468645)
2001
23
How to define coronary stenosis severity? (11387604)
2001
24
Quantitative evaluation of coronary stenosis by coronary magnetic resonance angiography. (11471654)
2000
25
Transesophageal echocardiography assessment of severe ostial left main coronary stenosis. (10887358)
2000
26
Transesophageal Echocardiographic Diagnosis of Coronary Stenosis in a Stroke Patient. (11175195)
1999
27
Clinical validation of intravascular ultrasound imaging for assessment of coronary stenosis severity: comparison with stress myocardial perfusion imaging. (10362187)
1999
28
A comparative study of eccentric and concentric coronary stenosis vasomotion in patients with Prinzmental's variant angina and patients with stable angina pectoris. (9755380)
1998
29
Sialic acid content of LDL in coronary artery disease: no evidence of desialylation in subjects with coronary stenosis and increased levels in subjects with extensive atherosclerosis and acute myocardial infarction: relation between desialylation and in vitro peroxidation. (9633926)
1998
30
Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging. (9529285)
1998
31
Unusual case of coronary stenosis caused by an external compression. (9431869)
1997
32
Low- and high-blood flow regions in the normal pig heart are equally vulnerable to ischaemia during partial coronary stenosis. (9306013)
1997
33
Identifying coronary stenosis using an image-recognition neural network. (9313092)
1997
34
Cardiac contractile function during coronary stenosis in dogs: association of adenosine in glycolytic dependence. (9176286)
1997
35
Coronary stenosis vasoconstriction: impact on myocardial ischaemia. (9447311)
1997
36
Coronary stenosis progression differs in patients with stable angina pectoris with and without a previous history of unstable angina. (8909904)
1996
37
Transesophageal dobutamine-atropine stress echocardiography: diagnostic accuracy for coronary stenosis detection and localization. (8894791)
1996
38
Evaluation of intramyocardial coronary blood flow waveform during intraaortic balloon pumping in the absence or presence of coronary stenosis. (8712964)
1996
39
Effects of dobutamine on myocardial blood flow, contractile function, and bioenergetic responses distal to coronary stenosis: implications with regard to dobutamine stress testing. (7832107)
1995
40
Role of coronary artery spasm in progression of organic coronary stenosis and acute myocardial infarction in a swine model. Importance of mode of onset and duration of coronary artery spasm. (8425301)
1993
41
Coronary angioplasty in high-risk patients with left main coronary stenosis: results from the National Registry of Elective Supported Angioplasty. (1571971)
1992
42
Relation of perfusion defects observed with myocardial contrast echocardiography to the severity of coronary stenosis: correlation with thallium-201 single-photon emission tomography. (1564236)
1992
43
Residual critical coronary stenosis during myocardial reperfusion is deleterious to myocardial salvage in dogs. (1404847)
1992
44
Coronary stenosis after successful angioplasty: clinical observations. (1764820)
1991
45
Effect of coronary stenosis on myocardial blood flow during exercise in the chronically pressure-overloaded hypertrophied left ventricle. (2140541)
1990
46
Effects of dipyridamole and aminophylline on hemodynamics, regional myocardial blood flow and thallium-201 washout in the setting of a critical coronary stenosis. (2254563)
1990
47
Effects of propranolol on coronary vasculature and cardiac performance in dogs with fixed and dynamic coronary stenosis. (2632837)
1989
48
Role of endogenous prostacyclin in myocardial blood flow regulation distal to a severe coronary stenosis. (3075513)
1988
49
Absence of coronary vascular reserve in myocardium distal to a fixed coronary stenosis. (3664547)
1987
50
Postperfusion coronary stenosis. (3662692)
1987

Variations for Coronary Stenosis

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Expression for genes affiliated with Coronary Stenosis

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Expression patterns in normal tissues for genes affiliated with Coronary Stenosis

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Pathways for genes affiliated with Coronary Stenosis

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Pathways related to Coronary Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5OLR1, PECAM1
29.5CETP, SOD3
3
Show member pathways
9.1FGA, PECAM1
49.1PECAM1, FGA
5
Show member pathways
8.7FGA, OLR1, PECAM1

Compounds for genes affiliated with Coronary Stenosis

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Compounds related to Coronary Stenosis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1fucoidan449.9PECAM1, OLR1
2pioglitazone28 44 50 1112.9OLR1, SOD3
3losartan44 50 28 1112.9OLR1, SOD3
4fenofibrate44 50 1111.9CETP, OLR1
5pravastatin44 50 28 24 1113.8CETP, OLR1
6linoleic acid28 44 2411.8OLR1, CETP
7inosine monophosphate449.8OLR1, CCL11
8alpha tocopherol449.8CETP, SOD3
9nitrate449.7CCL11, SOD3
10atorvastatin44 50 28 24 1113.7CETP, OLR1
11homocysteine44 2410.7CETP, SOD3
12allergens449.6CCL11, CETP
13simvastatin44 50 61 28 24 1114.6OLR1, CETP
14malondialdehyde449.5SOD3, FGA
15ascorbic acid44 2410.5OLR1, CETP, SOD3
16cgmp44 2810.4PECAM1, CCL11
17phospholipid449.4OLR1, CETP, PECAM1
18arginine449.3OLR1, CETP, SOD3
19peroxynitrite449.3CCL11, SOD3, PECAM1
20cyclosporin a44 28 6111.2PECAM1, CETP, CCL11
21prostacyclin449.1FGA, PECAM1
22vegf449.1PECAM1, SOD3, CCL11
23endotoxin449.0CCL11, FGA
24alanine449.0CCL11, CETP, SOD3
25cysteine448.9PECAM1, SOD3, CETP, OLR1
26superoxide44 249.9PECAM1, SOD3, CCL11, OLR1
27nitric oxide44 24 1110.9OLR1, CCL11, SOD3, PECAM1
28thymidine44 249.9FGA, CCL11, PECAM1
29oxygen44 249.9PECAM1, SOD3, CCL11, OLR1
30retinoic acid44 249.7PECAM1, CETP, CCL11
31histamine44 28 2410.5PECAM1, CCL11, OLR1, FGA
32serine448.5FGA, CETP, SOD3, PECAM1
33atp44 289.4FGA, OLR1, PECAM1
34aspirin44 50 28 2411.4FGA, CCL11, CETP, PECAM1
35cholesterol44 28 24 1111.2PECAM1, SOD3, CETP, OLR1, FGA
36heparin44 28 24 1110.9PECAM1, SOD3, CETP, CCL11, FGA
37lipid447.5FGA, OLR1, CCL11, CETP, SOD3, PECAM1

GO Terms for genes affiliated with Coronary Stenosis

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Cellular components related to Coronary Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6CETP, CCL11, OLR1, FGA, SOD3
2extracellular spaceGO:0056157.2FGA, CCL11, CETP, SOD3, PECAM1

Biological processes related to Coronary Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:0421579.6OLR1, CETP
2leukocyte migrationGO:0509009.2OLR1, PECAM1
3platelet degranulationGO:0025769.0PECAM1, FGA
4blood coagulationGO:0075968.7FGA, OLR1, PECAM1
5signal transductionGO:0071658.5FGA, CCL11, PECAM1

Products for genes affiliated with Coronary Stenosis

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Sources for Coronary Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet