MCID: CRN030
MIFTS: 47

Coronary Stenosis malady

Summaries for Coronary Stenosis

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Coronary Stenosis, also known as coronary artery stenosis, is related to acute myocardial infarction and coronary artery disease,. An important gene associated with Coronary Stenosis is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are LDL-mediated lipid transport and PPAR signaling pathway. The compounds uric acid and alpha tocopherol have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Coronary Stenosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
See all sources

Aliases & Descriptions:

coronary stenosis 8 10 45 61
coronary artery stenosis 8


External Ids:

Disease Ontology8 DOID:4248
NCIt40 C80427
SNOMED-CT57 233970002
MeSH35 D023921

Related Diseases for Coronary Stenosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Coronary Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction30.8PECAM1, SELP, OLR1, FGA, PON1, ITGAL
2coronary artery disease,30.8ADIPOQ, ADAMTSL1, CETP, PECAM1, SELP, OLR1
3atherosclerosis30.6ADIPOQ, ADAMTSL1, CETP, PECAM1, SELP, OLR1
4carotid stenosis30.2SELP, PON1
5insulin resistance30.1ADIPOQ, CETP, PON1, LIPC, LPA, SCARB1
6familial hypercholesterolemia29.9CETP, APOB
7hypercholesterolemia29.9ADIPOQ, CETP, SELP, OLR1, FGA, PON1
8coronary heart disease29.9ADIPOQ, CETP, PECAM1, SELP, OLR1, FGA
9angina pectoris10.5
10takayasu's arteritis10.4
11coronary aneurysm10.3
12kawasaki disease10.3
13hyperphosphatemia10.3
14coronary artery aneurysm10.3
15cardiogenic shock10.3
16coronary restenosis10.2
17aortic valve stenosis10.2
18lip disease10.2
19relapsing polychondritis10.1
20williams-beuren syndrome10.1
21subendocardial myocardial infarction10.1
22inferior myocardial infarction10.1
23brain disease10.1
24williams syndrome10.1
25pulmonary supravalvular stenosis10.1
26syncope10.1
27tako-tsubo cardiomyopathy10.1
28coronary sinus stenosis10.1
29hypertrophic cardiomyopathy10.1
30myocardial stunning10.1
31apical myocardial infarction10.1
32n syndrome10.1
33cogan's syndrome10.1
34hepatitis10.0CCL11
35diabetic retinopathy10.0PON1
36pancreatitis10.0SELP
37protein s deficiency10.0FGA
38infertility10.0PON1
39age related macular degeneration10.0LIPC
40ovarian cancer10.0FGA
41colorectal cancer10.0SELP
42growth hormone deficiency10.0ADIPOQ
43xanthomatosis10.0APOB
44periodontitis10.0TLR4
45acute pancreatitis10.0TLR4
46neuropathy10.0PIK3C2A
47chylomicron retention disease10.0APOB
48sarcoidosis10.0SELP, CCL11
49cholestasis10.0CETP, LIPC
50amyotrophic lateral sclerosis10.0ADAMTSL1, PON1

Graphical network of the top 20 diseases related to Coronary Stenosis:



Diseases related to coronary stenosis

Clinical Features for Coronary Stenosis

Drugs & Therapeutics for Coronary Stenosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Coronary Stenosis

Drug clinical trials:

Search ClinicalTrials for Coronary Stenosis

Search NIH Clinical Center for Coronary Stenosis

Search CenterWatch for Coronary Stenosis

Genetic Tests for Coronary Stenosis

Anatomical Context for Coronary Stenosis

Animal Models for Coronary Stenosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Coronary Stenosis

Sources:
51PubMed
See all sources

Articles related to Coronary Stenosis:

(show top 50)    (show all 722)
idTitleAuthorsYear
1
Beyond Coronary Stenosis: Coronary Computed Tomographic Angiography for the Assessment of Atherosclerotic Plaque Burden. (23524381)
2013
2
Carotid artery stenting in patients with acute coronary syndrome: a possible primary therapy for symptomatic carotid stenosis. (23914865)
2013
3
Echocardiographic assessment of right ventricular function in inferior wall myocardial infarction and angiographic correlation to proximal right coronary artery stenosis. (24206875)
2013
4
CT coronary angiography: impact of adapted statistical iterative reconstruction (ASIR) on coronary stenosis and plaque composition analysis. (23053859)
2013
5
Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease. (23670230)
2013
6
Single coronary artery associated with severe bicuspid aortic valve stenosis. (24198454)
2013
7
Optical coherence tomography-derived anatomical criteria for functionally significant coronary stenosis assessed by fractional flow reserve. (22785153)
2012
8
Coronary stenosis, Crohn's disease and epicardial adipose tissue. (22293813)
2012
9
Extracranial carotid stenosis and peripheral arterial disease in Thai patients with coronary artery disease. (20483809)
2010
10
Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US. (19130178)
2009
11
Cerebral hemodynamics during coronary artery bypass graft surgery: the effect of carotid stenosis. (19540657)
2009
12
Progressive left coronary stenosis after rotablator ablation appreciated by Doppler echocardiography. (19784696)
2009
13
Influence of genetic polymorphism in matrix metalloproteinase-3 on extent of coronary atherosclerosis and risk of coronary artery stenosis. (20082876)
2009
14
Is there any difference in carotid stenosis between male and female patients undergoing coronary artery bypass grafting? (19687046)
2009
15
Does metabolic syndrome predict silent carotid stenosis in coronary patients? (18283528)
2008
16
Comparison of quantitative coronary angiography and first-pass perfusion magnetic resonance imaging for the detection of an impaired coronary perfusion in nonsevere coronary stenosis. (18425839)
2008
17
Assessment of coronary stenosis by a 16-slice MDCT scanner in asymptomatic diabetic patients starting dialysis therapy. (18560241)
2008
18
Effect of obesity on the relationship between plasma C-reactive protein and coronary artery stenosis in patients with stable angina. (16024024)
2006
19
Percutaneous transluminal coronary angioplasty in a two-month old with coronary stenosis presenting as congenital cardiomyopathy: acute results and intermediate follow-up. (16969876)
2006
20
Dual coronary artery fistula in a patient with aortic valve stenosis. (16520126)
2006
21
Sudden onset of "cardiac" symptoms, (?) mild or severe aortic valve stenosis involving a congenitally bicuspid aortic valve, and nearly normal coronary arteries in an octogenarian. (16687972)
2006
22
Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions. (17101559)
2006
23
Successful management of left main coronary artery stenosis with a paclitaxel-eluting stent in Takayasu's arteritis. (16516707)
2006
24
Increased expression of monocyte CD11a and intracellular adhesion molecule-1 in patients with initial atherosclerotic coronary stenosis. (14695458)
2004
25
Supravalvular aortic stenosis and coronary ostial stenosis in homozygous familial hypercholesterolemia. (15377140)
2004
26
TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis. (12957699)
2003
27
Inflammatory parameters are independent predictors of severe epicardial coronary stenosis in asymptomatic diabetic patients with silent myocardial ischemia. (12547901)
2003
28
Association of severe coronary stenosis with subclinical left ventricular dysfunction in the absence of infarction. (14608288)
2003
29
Polymorphism in the gelatinase B gene and the severity of coronary arterial stenosis. (11410119)
2001
30
The relationship of oxidized lipids to coronary artery stenosis. (10704630)
2000
31
Preperitoneal fat thickness determined by ultrasonography is correlated with coronary stenosis and lipid disorders in non-obese male subjects. (10805509)
2000
32
Sex steroids versus lipid profile and the degree of coronary artery stenosis in men with angiographically documented coronary artery disease]. (11291607)
2000
33
A comparative study of eccentric and concentric coronary stenosis vasomotion in patients with Prinzmental's variant angina and patients with stable angina pectoris. (9755380)
1998
34
Low- and high-blood flow regions in the normal pig heart are equally vulnerable to ischaemia during partial coronary stenosis. (9306013)
1997
35
Aortitis, aortic valve incompetence, and left coronary ostium stenosis in a patient with C-ANCA-associated necrotizing vasculitis. (9175229)
1997
36
Coronary stenosis dilatation induced by L-arginine. (9269220)
1997
37
Myocardial uptake and washout kinetics of T1-201 with the VEX (vasodilator plus exercise) test: contribution of stress mode components and coronary stenosis severity. (8689535)
1996
38
Primary melanoma of the heart: case report of an association with coronary stenosis. (8855436)
1996
39
Failure of calcium channel blockade to reduce platelet-mediated cyclic flow variations in dogs with coronary stenosis and endothelial injury. (8569218)
1995
40
Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis. (7697839)
1995
41
Coronary stenosis significance: lessons learned from recent trials. (7819630)
1994
42
Sudden death, right ventricular infarction, and abnormal right ventricular intramural coronary arteries in isolated congenital valvular pulmonic stenosis. (8342524)
1993
43
Clinically isolated left coronary ostial stenosis: a manifestation of cardiovascular syphilis--case history. (8239065)
1993
44
Effect of coronary stenosis on myocardial blood flow during exercise in the chronically pressure-overloaded hypertrophied left ventricle. (2140541)
1990
45
Aorta-coronary bypass grafting for bilateral coronary ostial stenosis caused by Takayasu's aortitis. (1970368)
1990
46
Coronary stenosis dilation by low dose intravenous nitroglycerin. (2515967)
1989
47
Assessment of regional myocardial perfusion by contrast echocardiography. II. Detection of changes in transmural and subendocardial perfusion during dipyridamole-induced hyperemia in a model of critical coronary stenosis. (2681325)
1989
48
Characteristics of regional myocardial stunning after exercise in dogs with chronic coronary stenosis. (2750931)
1989
49
Value of fluoroscopy in the detection of coronary stenosis: influence of age, sex, and number of vessels calcified on diagnostic efficacy. (3341167)
1988
50
Dynamic behaviour of coronary stenosis in response to increasing heart rate in the dog. (3256415)
1988

Genetic Variations for Coronary Stenosis

Expression for genes affiliated with Coronary Stenosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Coronary Stenosis

Search GEO for disease gene expression data for Coronary Stenosis.

Pathways for genes affiliated with Coronary Stenosis

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Coronary Stenosis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0APOB, LPA, CETP
210.0ADIPOQ, OLR1, APOA1
310.0SOD3, APOA1, SCARB1
410.0APOB, CETP, ADIPOQ
510.0LPA, APOB, APOA1
610.0APOB, LPA, SELP
79.9APOB, APOA1, COL3A1
89.9APOA1, APOB, SCARB1
99.9SCARB1, APOB, APOA1
109.9SCARB1, APOB, APOA1
119.9PECAM1, ITGAL, TLR4
12
Hide members
9.9FGA, OLR1, SELP, PECAM1
13
Hide members
9.9APOA1, FGA, SELP, PECAM1
149.9SOD3, APOB, CETP, ADIPOQ
159.8SOD3, APOA1, APOB, SCARB1
16
Hide members
9.8COL3A1, ITGAL, FGA, PECAM1
17
Hide members
9.7COL3A1, APOA1, APOB, SCARB1
18
Hide members
9.7APOA1, APOB, SCARB1, LPA, CETP
19
Hide members
9.6CETP, LIPC, SCARB1, APOB, APOA1
209.6APOB, ITGAL, OLR1, SELP, PECAM1
21
Hide members
9.2APOA1, APOB, SCARB1, PIK3C2A, LPA, LIPC
22
Hide members
9.1COL3A1, CCL11, HTR2A, APOA1, APOB, ITGAL

Compounds for genes affiliated with Coronary Stenosis

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Coronary Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1uric acid45 2411.5PIK3C2A, SOD3
2alpha tocopherol4510.4ITGAL, SCARB1
3superoxide45 2411.2LPA, ITGAL, OLR1, SOD3
4estrogen4510.2LPA, ADAMTSL1, CETP, LIPC
5acipimox45 2911.0APOB, ADIPOQ, CETP, APOA1
6glucose4510.0APOA1, SCARB1, PIK3C2A, LPA, OLR1
7probucol45 1111.0CETP, SCARB1, APOB, APOA1, LIPC
8ezetimibe45 1111.0SCARB1, APOA1, ADIPOQ, APOB, CETP
9warfarin45 50 11 2412.9PIK3C2A, LPA, FGA, SELP
10dextran sulfate459.9SELP, APOB, CETP, ADAMTSL1, APOA1
11niacin45 1110.9SCARB1, LPA, CETP, APOB, APOA1, ADIPOQ
12aspartate459.8PIK3C2A, APOA1, COL3A1, CETP, ADAMTSL1
13h2o2459.8ADIPOQ, ADAMTSL1, PON1, ITGAL, PECAM1, LPA
14cholesterol ester459.8CETP, LIPC, PON1, LPA, APOB, APOA1
15gemfibrozil45 29 1111.7LPA, LIPC, CETP, PON1, APOA1, APOB
16pioglitazone45 50 29 1112.7SCARB1, SOD3, APOB, ADIPOQ, OLR1, LIPC
17bezafibrate45 29 1111.7CETP, ADIPOQ, LPA, PIK3C2A, APOB, APOA1
18ascorbic acid45 2410.7PON1, ADIPOQ, SOD3, PIK3C2A, OLR1, CETP
19phosphatidylcholine459.7APOA1, SCARB1, LIPC, APOB, CETP, PON1
20triacylglycerol459.7CETP, LIPC, APOB, APOA1, ADIPOQ
21fluvastatin45 50 29 1112.6PON1, CETP, SELP, PIK3C2A, APOB, APOA1
22carbohydrates459.6TLR4, SCARB1, LIPC, CETP, ADIPOQ, SELP
23prostacyclin459.6SELP, ADAMTSL1, FGA, PIK3C2A, APOA1, PECAM1
24malondialdehyde459.6FGA, LPA, PIK3C2A, SOD3, PON1
25intralipid459.5CETP, LIPC, APOB, APOA1
26vitamin a45 11 2411.5LIPC, APOA1, APOB, SCARB1, ADIPOQ, LPA
27thyroxine45 2410.5APOA1, LPA, APOB, PON1, LIPC, ADIPOQ
28serine459.5LIPC, TLR4, ADIPOQ, PECAM1, FGA, CETP
29lovastatin45 50 60 29 1113.5LPA, ITGAL, PIK3C2A, APOB, LIPC, PON1
30sterol459.5LIPC, CETP, ADIPOQ, SCARB1, APOB, APOA1
31homocysteine45 2410.5SOD3, APOA1, APOB, ADIPOQ, CETP, SELP
32creatinine459.4APOA1, APOB, LPA, PON1, PIK3C2A, SELP
33acetylcholine45 50 29 11 2413.4ADIPOQ, FGA, PON1, PIK3C2A, TLR4, APOA1
34fatty acid459.3APOB, SCARB1, PIK3C2A, LPA, LIPC, ADIPOQ
35arginine459.2PIK3C2A, LIPC, SOD3, CETP, SELP, ADIPOQ
36pravastatin45 50 29 11 2413.2ITGAL, LPA, PIK3C2A, OLR1, SELP, CETP
37vegf459.2SELP, ADAMTSL1, APOB, LPA, PIK3C2A, SOD3
38cysteine459.1TLR4, SELP, PECAM1, OLR1, PON1, ITGAL
39nitric oxide45 11 2411.1OLR1, PECAM1, SOD3, CCL11, TLR4, SELP
40fenofibrate45 50 1111.1ADIPOQ, CETP, SELP, OLR1, PON1, LIPC
41cyclosporin a45 29 6011.1CETP, ADAMTSL1, PIK3C2A, ITGAL, CCL11, LIPC
42phospholipid459.1ADIPOQ, ADAMTSL1, CETP, PECAM1, PON1, LIPC
43alanine458.9CCL11, CETP, PON1, ADIPOQ, ITGAL, PIK3C2A
44atorvastatin45 50 29 11 2412.8APOB, SCARB1, PIK3C2A, LPA, LIPC, PON1
45simvastatin45 50 60 29 11 2413.8CETP, SELP, OLR1, TLR4, APOA1, APOB
46heparin45 29 11 2411.8SOD3, LPA, ITGAL, PON1, FGA, PECAM1
47fibrinogen458.6TLR4, ADIPOQ, ADAMTSL1, PECAM1, APOA1, APOB
48aspirin45 50 29 2411.6CCL11, TLR4, APOA1, APOB, SCARB1, LPA
49lipid458.1FGA, OLR1, PECAM1, CETP, ADAMTSL1, ADIPOQ
50cholesterol45 29 11 2411.0ADIPOQ, LPA, ITGAL, LIPC, PON1, FGA

GO Terms for genes affiliated with Coronary Stenosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Coronary Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.1APOB, APOA1
2platelet alpha granule membraneGO:03109210.1SELP, PECAM1
3high-density lipoprotein particleGO:03436410.0LIPC, CETP, PON1, APOA1
4spherical high-density lipoprotein particleGO:0343669.9PON1, APOA1
5external side of plasma membraneGO:0098979.7FGA, SELP, TLR4, ITGAL
6extracellular regionGO:0055769.1ADIPOQ, CETP, OLR1, FGA, PON1, LPA
7extracellular spaceGO:0056158.8ADIPOQ, SELP, FGA, PON1, LIPC, APOB
8plasma membraneGO:0058868.6TLR4, HTR2A, APOA1, APOB, SCARB1, OLR1

Biological processes related to Coronary Stenosis according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:04215810.5APOA1, APOB
2cholesterol importGO:07050810.4SCARB1, APOA1
3very-low-density lipoprotein particle remodelingGO:03437210.4LIPC, CETP
4positive regulation of platelet activationGO:01057210.4TLR4, SELP
5negative regulation of heterotypic cell-cell adhesionGO:03411510.4APOA1, ADIPOQ
6high-density lipoprotein particle clearanceGO:03438410.4APOA1, SCARB1
7detection of lipopolysaccharideGO:03249710.4SCARB1, TLR4
8cholesterol transportGO:03030110.4CETP, APOB, APOA1
9phosphatidylcholine metabolic processGO:04647010.4CETP, PON1
10low-density lipoprotein particle remodelingGO:03437410.4APOB, LIPC, CETP
11negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.3APOA1, ADIPOQ
12phospholipid transportGO:01591410.3CETP, SCARB1
13phospholipid homeostasisGO:05509110.3APOA1, CETP
14positive regulation of cholesterol storageGO:01088610.3APOB, SCARB1
15receptor-mediated endocytosisGO:00689810.3CETP, LPA, APOB
16leukocyte cell-cell adhesionGO:00715910.3ITGAL, OLR1, SELP
17low-density lipoprotein particle clearanceGO:03438310.3ADIPOQ, SCARB1, APOB
18cholesterol effluxGO:03334410.3SCARB1, APOB, APOA1
19platelet degranulationGO:00257610.2APOA1, FGA, SELP, PECAM1
20high-density lipoprotein particle remodelingGO:03437510.2APOA1, SCARB1, LIPC, CETP
21reverse cholesterol transportGO:04369110.2APOA1, SCARB1, LIPC, CETP
22triglyceride homeostasisGO:07032810.2CETP, LIPC, SCARB1, APOA1
23blood vessel endothelial cell migrationGO:04353410.2APOA1, SCARB1
24positive regulation of cholesterol effluxGO:01087510.2ADIPOQ, PON1
25cholesterol metabolic processGO:00820310.1APOA1, APOB, LIPC, PON1, CETP
26negative regulation of macrophage derived foam cell differentiationGO:01074510.1CETP, ADIPOQ
27platelet activationGO:03016810.1COL3A1, APOA1, FGA, SELP, PECAM1
28cholesterol homeostasisGO:04263210.0CETP, LIPC, SCARB1, APOB, APOA1
29leukocyte migrationGO:05090010.0APOB, ITGAL, OLR1, SELP, PECAM1
30lipoprotein metabolic processGO:0421579.9CETP, OLR1, LPA, SCARB1, APOB, APOA1
31cell adhesionGO:0071559.9CCL11, SCARB1, ITGAL, SELP, PECAM1
32endothelial cell proliferationGO:0019359.8APOA1, SCARB1
33inflammatory responseGO:0069549.8SELP, OLR1, ITGAL, CCL11
34blood coagulationGO:0075969.7APOA1, APOB, ITGAL, FGA, OLR1, SELP

Molecular functions related to Coronary Stenosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1phospholipid transporter activityGO:00554810.2APOA1, CETP
2cholesterol transporter activityGO:01712710.2APOA1, APOB, CETP
3lipopolysaccharide receptor activityGO:00187510.1SCARB1, TLR4
4low-density lipoprotein particle bindingGO:03016910.1LIPC, SCARB1
5apolipoprotein bindingGO:03418510.1SCARB1, LPA, LIPC
6high-density lipoprotein particle bindingGO:00803510.0SCARB1, APOA1
7lipopolysaccharide bindingGO:00153010.0TLR4, SCARB1, SELP
8heparin bindingGO:0082019.9SELP, LIPC, LPA, APOB, SOD3
9sialic acid bindingGO:0336919.8ADIPOQ, SELP

Products for genes affiliated with Coronary Stenosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coronary Stenosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet