MCID: CRN030
MIFTS: 43

Coronary Stenosis malady

Cardiovascular diseases category
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Summaries for Coronary Stenosis

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33MalaCards
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MalaCards: Coronary Stenosis, also known as coronary artery stenosis, is related to ischemia and coronary artery disease. An important gene associated with Coronary Stenosis is OLR1 (oxidized low density lipoprotein (lectin-like) receptor 1), and among its related pathways are Cell surface interactions at the vascular wall and Selected targets of C EBPbeta. The compounds fucoidan and pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related mouse phenotype immune system.

Aliases & Classifications for Coronary Stenosis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

coronary stenosis 8 10 45 62
coronary artery stenosis 8


External Ids:

Disease Ontology8 DOID:4248
NCIt40 C80427
SNOMED-CT58 233970002
MeSH35 D023921

Related Diseases for Coronary Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Coronary Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.8PECAM1, OLR1, FGA
2coronary artery disease30.7FGA, OLR1, CETP, PECAM1
3myocardial infarction30.7SOD3, FGA, OLR1, PECAM1, CETP, CCL11
4acute myocardial infarction30.7OLR1, SOD3, PECAM1, FGA
5atherosclerosis30.4OLR1, CETP, CCL11, FGA, SOD3, PECAM1
6insulin resistance30.2SOD3, CETP, CCL11
7hypercholesterolemia29.9FGA, CETP, OLR1
8pneumonia29.9SOD3, CCL11, FGA
9diabetes mellitus29.9PECAM1, CETP, OLR1, FGA
10artery disease10.6
11angina pectoris10.5
12takayasu's arteritis10.4
13kawasaki disease10.3
14aneurysm10.3
15endotheliitis10.3
16hyperphosphatemia10.3
17cardiogenic shock10.3
18mediastinitis10.3
19williams-beuren syndrome10.1
20relapsing polychondritis10.1
21hypertrophic cardiomyopathy10.1
22coronary aneurysm10.1
23subendocardial myocardial infarction10.1
24hypertension10.1
25periodontitis10.1
26pulmonary embolism10.1
27cogan's syndrome10.1
28coronary artery aneurysm10.1
29syncope10.1
30familial hyperlipidemia10.0OLR1, CETP
31cerebrovascular disease10.0CETP, SOD3
32vascular disease10.0SOD3
33congenital heart disease10.0CETP, SOD3
34food allergy10.0CETP, CCL11
35pulmonary disease, chronic obstructive10.0CCL11, SOD3
36venous thrombosis10.0CETP, FGA
37crohn's disease10.0
38supravalvular aortic stenosis10.0
39pseudoxanthoma elasticum10.0
40aortitis10.0
41abdominal aortic aneurysm10.0
42myocardial stunning10.0
43churg-strauss syndrome10.0
44cerebritis10.0
45familial hypercholesterolemia10.0
46moyamoya disease10.0
47aortic aneurysm10.0
48aortic valve stenosis10.0
49dermatomyositis10.0
50ehlers-danlos syndrome10.0

Graphical network of the top 20 diseases related to Coronary Stenosis:



Diseases related to coronary stenosis

Symptoms for Coronary Stenosis

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Drugs & Therapeutics for Coronary Stenosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Coronary Stenosis

Search NIH Clinical Center for Coronary Stenosis

Genetic Tests for Coronary Stenosis

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Anatomical Context for Coronary Stenosis

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33MalaCards
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MalaCards organs/tissues related to Coronary Stenosis:

33
Heart, Testes, Endothelial, Brain, Bone marrow, Bone, Liver, Monocytes

Animal Models for Coronary Stenosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Coronary Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6FGA, OLR1, CCL11, SOD3, PECAM1

Publications for Coronary Stenosis

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52PubMed
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Articles related to Coronary Stenosis:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
Shoulder technique: A modified sleeve technique devised for treating isolated coronary stenosis at side branch ostium. (24342408)
2014
2
Non-contrast 1.5T FIESTA magnetic resonance angiography and 64-multidetector computed tomographic angiography have a similar accuracy for the detection of proximal coronary stenosis. (23706328)
2013
3
Side branch ostium stenting with main vessel drug-eluting balloon kissing (BOMB): an innovative approach for isolated coronary stenosis at side branch ostium. (23907034)
2013
4
Beyond Coronary Stenosis: Coronary Computed Tomographic Angiography for the Assessment of Atherosclerotic Plaque Burden. (23524381)
2013
5
Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters. (24368093)
2013
6
Visceral adipose tissue area is associated with coronary stenosis and noncalcified plaques. (23748189)
2013
7
Propensity score matched lesion-based comparison of long-term clinical and angiographic outcomes after placement of sirolimus (Cypher Bx Velocity) and paclitaxel (TAXUS Express)-eluting stents for de novo native coronary stenosis. (24122399)
2013
8
Dual-source computed tomography for evaluating coronary stenosis and left ventricular function. (24137298)
2013
9
The exercise treadmill test: predictors of true presence of significant coronary stenosis in patients with severe ST-segment depression. (22870737)
2012
10
Angina without significant coronary stenosis of non vasospastic origin. Clinical profile and long-term follow-up of patients with vs patients without stress induced ST segment depression. (22748501)
2012
11
Incremental value of myocardial perfusion over regional left ventricular function and coronary stenosis by cardiac CT for the detection of acute coronary syndromes in high-risk patients: a subgroup analysis of the ROMICAT trial. (22146497)
2011
12
The case of disappearing coronary stenosis. (21180043)
2010
13
Power changes with treatment of coronary stenosis in a highly trained cyclist. (20606521)
2010
14
Left main coronary stenosis as a consequence of bentall operation: percutaneous treatment. (19946628)
2009
15
Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US. (19130178)
2009
16
Surgery, not percutaneous revascularization, is the preferred strategy for patients with significant left main coronary stenosis. (19237672)
2009
17
What coronary stenosis needs PCI/stent? (17680615)
2007
18
Increased expression of monocyte CD11a and intracellular adhesion molecule-1 in patients with initial atherosclerotic coronary stenosis. (14695458)
2004
19
Attenuation of heart failure due to coronary stenosis by ACE inhibitor and angiotensin receptor blocker. (12649073)
2003
20
Transesophageal echocardiographic assessment of coronary stenosis: a decade of experience. (11182783)
2001
21
A comparison of quantitative coronary angiography systems using a unique set of in vivo coronary stenosis images. (11468645)
2001
22
How to define coronary stenosis severity? (11387604)
2001
23
Quantitative evaluation of coronary stenosis by coronary magnetic resonance angiography. (11471654)
2000
24
Transesophageal echocardiography assessment of severe ostial left main coronary stenosis. (10887358)
2000
25
Transesophageal Echocardiographic Diagnosis of Coronary Stenosis in a Stroke Patient. (11175195)
1999
26
Clinical validation of intravascular ultrasound imaging for assessment of coronary stenosis severity: comparison with stress myocardial perfusion imaging. (10362187)
1999
27
A comparative study of eccentric and concentric coronary stenosis vasomotion in patients with Prinzmental's variant angina and patients with stable angina pectoris. (9755380)
1998
28
Sialic acid content of LDL in coronary artery disease: no evidence of desialylation in subjects with coronary stenosis and increased levels in subjects with extensive atherosclerosis and acute myocardial infarction: relation between desialylation and in vitro peroxidation. (9633926)
1998
29
Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging. (9529285)
1998
30
Unusual case of coronary stenosis caused by an external compression. (9431869)
1997
31
Low- and high-blood flow regions in the normal pig heart are equally vulnerable to ischaemia during partial coronary stenosis. (9306013)
1997
32
Identifying coronary stenosis using an image-recognition neural network. (9313092)
1997
33
Cardiac contractile function during coronary stenosis in dogs: association of adenosine in glycolytic dependence. (9176286)
1997
34
Coronary stenosis vasoconstriction: impact on myocardial ischaemia. (9447311)
1997
35
Coronary stenosis progression differs in patients with stable angina pectoris with and without a previous history of unstable angina. (8909904)
1996
36
Transesophageal dobutamine-atropine stress echocardiography: diagnostic accuracy for coronary stenosis detection and localization. (8894791)
1996
37
Evaluation of intramyocardial coronary blood flow waveform during intraaortic balloon pumping in the absence or presence of coronary stenosis. (8712964)
1996
38
Effects of dobutamine on myocardial blood flow, contractile function, and bioenergetic responses distal to coronary stenosis: implications with regard to dobutamine stress testing. (7832107)
1995
39
Coronary stenosis associated with aneurysm: treatment with elective stenting in two patients. (7590844)
1995
40
Role of coronary artery spasm in progression of organic coronary stenosis and acute myocardial infarction in a swine model. Importance of mode of onset and duration of coronary artery spasm. (8425301)
1993
41
Coronary angioplasty in high-risk patients with left main coronary stenosis: results from the National Registry of Elective Supported Angioplasty. (1571971)
1992
42
Relation of perfusion defects observed with myocardial contrast echocardiography to the severity of coronary stenosis: correlation with thallium-201 single-photon emission tomography. (1564236)
1992
43
Residual critical coronary stenosis during myocardial reperfusion is deleterious to myocardial salvage in dogs. (1404847)
1992
44
Coronary stenosis after successful angioplasty: clinical observations. (1764820)
1991
45
Effect of coronary stenosis on myocardial blood flow during exercise in the chronically pressure-overloaded hypertrophied left ventricle. (2140541)
1990
46
Effects of dipyridamole and aminophylline on hemodynamics, regional myocardial blood flow and thallium-201 washout in the setting of a critical coronary stenosis. (2254563)
1990
47
Effects of propranolol on coronary vasculature and cardiac performance in dogs with fixed and dynamic coronary stenosis. (2632837)
1989
48
Role of endogenous prostacyclin in myocardial blood flow regulation distal to a severe coronary stenosis. (3075513)
1988
49
Absence of coronary vascular reserve in myocardium distal to a fixed coronary stenosis. (3664547)
1987
50
Postperfusion coronary stenosis. (3662692)
1987

Variations for Coronary Stenosis

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Expression for genes affiliated with Coronary Stenosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coronary Stenosis

Search GEO for disease gene expression data for Coronary Stenosis.

Pathways for genes affiliated with Coronary Stenosis

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50PathCards, 55Reactome, 12EMD Millipore
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Pathways related to Coronary Stenosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5OLR1, PECAM1
29.5CETP, SOD3
3
Show member pathways
9.1FGA, PECAM1
49.1PECAM1, FGA
5
Show member pathways
8.7FGA, OLR1, PECAM1

Compounds for genes affiliated with Coronary Stenosis

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience
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Compounds related to Coronary Stenosis according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1fucoidan459.9PECAM1, OLR1
2pioglitazone29 45 51 1112.9OLR1, SOD3
3losartan45 51 29 1112.9OLR1, SOD3
4fenofibrate45 51 1111.9CETP, OLR1
5pravastatin45 51 29 24 1113.8CETP, OLR1
6linoleic acid29 45 2411.8OLR1, CETP
7inosine monophosphate459.8OLR1, CCL11
8alpha tocopherol459.8CETP, SOD3
9nitrate459.7CCL11, SOD3
10atorvastatin45 51 29 24 1113.7CETP, OLR1
11homocysteine45 2410.7CETP, SOD3
12allergens459.6CCL11, CETP
13simvastatin45 51 61 29 24 1114.6OLR1, CETP
14malondialdehyde459.5SOD3, FGA
15ascorbic acid45 2410.5OLR1, CETP, SOD3
16cgmp45 2910.4PECAM1, CCL11
17phospholipid459.4OLR1, CETP, PECAM1
18arginine459.3OLR1, CETP, SOD3
19peroxynitrite459.3CCL11, SOD3, PECAM1
20cyclosporin a45 29 6111.2PECAM1, CETP, CCL11
21prostacyclin459.1FGA, PECAM1
22vegf459.1PECAM1, SOD3, CCL11
23endotoxin459.0CCL11, FGA
24alanine459.0CCL11, CETP, SOD3
25cysteine458.9PECAM1, SOD3, CETP, OLR1
26superoxide45 249.9PECAM1, SOD3, CCL11, OLR1
27nitric oxide45 24 1110.9OLR1, CCL11, SOD3, PECAM1
28thymidine45 249.9FGA, CCL11, PECAM1
29oxygen45 249.9PECAM1, SOD3, CCL11, OLR1
30retinoic acid45 249.7PECAM1, CETP, CCL11
31histamine45 29 2410.5PECAM1, CCL11, OLR1, FGA
32serine458.5FGA, CETP, SOD3, PECAM1
33atp45 299.4FGA, OLR1, PECAM1
34aspirin45 51 29 2411.4FGA, CCL11, CETP, PECAM1
35cholesterol45 29 24 1111.2PECAM1, SOD3, CETP, OLR1, FGA
36heparin45 29 24 1110.9PECAM1, SOD3, CETP, CCL11, FGA
37lipid457.5FGA, OLR1, CCL11, CETP, SOD3, PECAM1

GO Terms for genes affiliated with Coronary Stenosis

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16Gene Ontology
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Cellular components related to Coronary Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6SOD3, CETP, CCL11, OLR1, FGA
2extracellular spaceGO:0056157.2PECAM1, SOD3, CETP, CCL11, FGA

Biological processes related to Coronary Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:0421579.6CETP, OLR1
2leukocyte migrationGO:0509009.2OLR1, PECAM1
3platelet degranulationGO:0025769.0FGA, PECAM1
4blood coagulationGO:0075968.7OLR1, PECAM1, FGA
5signal transductionGO:0071658.5PECAM1, CCL11, FGA

Products for genes affiliated with Coronary Stenosis

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  • Antibodies
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Sources for Coronary Stenosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet