MCID: CRN030
MIFTS: 53

Coronary Stenosis malady

Summaries for Coronary Stenosis

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32MalaCards
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MalaCards: Coronary Stenosis, also known as coronary artery stenosis, is related to myocardial infarction and acute myocardial infarction. An important gene associated with Coronary Stenosis is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are LDL-mediated lipid transport and PPAR signaling pathway. The compounds uric acid and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and testes, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Coronary Stenosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

coronary stenosis 8 10 44 60
coronary artery stenosis 8


External Ids:

Disease Ontology8 DOID:4248
NCIt39 C80427
SNOMED-CT56 233970002
MeSH34 D023921

Related Diseases for Coronary Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Coronary Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction30.9ADIPOQ, ADAMTSL1, CETP, PECAM1, SELP, OLR1
2acute myocardial infarction30.8PECAM1, SELP, OLR1, FGA, PON1, ITGAL
3coronary artery disease30.8ADIPOQ, ADAMTSL1, CETP, PECAM1, SELP, OLR1
4ischemia30.7PECAM1, SELP, OLR1, FGA, PON1, ITGAL
5atherosclerosis30.6ADIPOQ, ADAMTSL1, CETP, PECAM1, SELP, OLR1
6periodontitis30.1TLR4
7carotid stenosis30.1SELP, PON1
8hypertension30.1OLR1, LPA, APOB, APOA1
9carotid artery disease29.9PON1, APOB
10familial hypercholesterolemia29.9CETP, APOB
11non-hodgkin lymphoma29.9PECAM1, FGA, PON1, ITGAL
12cerebrovascular disease29.9CETP, SELP, PON1, APOB, APOA1, SOD3
13pneumonia29.9FGA, PIK3C2A, SOD3, TLR4, CCL11
14type 2 diabetes mellitus29.9ADIPOQ, CETP, SELP, PON1, LIPC, LPA
15obesity29.9ADIPOQ, CETP, PON1, LIPC, LPA, SCARB1
16ischemic heart disease29.9ADAMTSL1, CETP, SELP, OLR1, FGA, PON1
17diabetes mellitus29.9ADIPOQ, ADAMTSL1, CETP, PECAM1, SELP, OLR1
18angina pectoris10.4
19takayasu's arteritis10.3
20coronary aneurysm10.3
21kawasaki disease10.3
22hyperphosphatemia10.3
23mediastinitis10.3
24coronary restenosis10.2
25aortic valve stenosis10.2
26relapsing polychondritis10.1
27williams-beuren syndrome10.1
28subendocardial myocardial infarction10.1
29inferior myocardial infarction10.1
30brain disease10.1
31pulmonary embolism10.1
32williams syndrome10.1
33hypertrophic cardiomyopathy10.1
34myocardial stunning10.1
35apical myocardial infarction10.1
36hepatitis10.0CCL11
37diabetic retinopathy10.0PON1
38pancreatitis10.0SELP
39protein s deficiency10.0FGA
40infertility10.0PON1
41age related macular degeneration10.0LIPC
42ovarian cancer10.0FGA
43colorectal cancer10.0SELP
44growth hormone deficiency10.0ADIPOQ
45xanthomatosis10.0APOB
46acute pancreatitis10.0TLR4
47neuropathy10.0PIK3C2A
48chylomicron retention disease10.0APOB
49sarcoidosis10.0SELP, CCL11
50cholestasis10.0CETP, LIPC

Graphical network of the top 20 diseases related to Coronary Stenosis:



Diseases related to coronary stenosis

Clinical Features for Coronary Stenosis

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Drugs & Therapeutics for Coronary Stenosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Coronary Stenosis

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Anatomical Context for Coronary Stenosis

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32MalaCards
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MalaCards organs/tissues related to Coronary Stenosis:

32
Heart, Endothelial, Testes, Brain, Monocytes, Bone marrow, Bone, Liver

Animal Models for Coronary Stenosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Coronary Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9COL3A1, TLR4, APOA1, APOB, SCARB1, FGA
2MP:00053978.7TLR4, APOA1, SCARB1, PIK3C2A, ITGAL, FGA
3MP:00053858.5COL3A1, TLR4, APOA1, APOB, SCARB1, PON1
4MP:00053878.1SCARB1, APOA1, SOD3, TLR4, CCL11, PIK3C2A
5MP:00053767.9ADIPOQ, COL3A1, TLR4, SOD3, APOA1, APOB

Publications for Coronary Stenosis

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50PubMed
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Articles related to Coronary Stenosis:

(show top 50)    (show all 720)
idTitleAuthorsYear
1
Evaluation of hemodynamically severe coronary stenosis as determined by fractional flow reserve with frequency domain optical coherence tomography measured anatomical parameters. (24368093)
2013
2
Functional coronary stenosis severity assessed from the mean pressure gradient-velocity relationship obtained by contrast medium-induced submaximal hyperaemia. (24334853)
2013
3
Clinical validation of the resting pressure parameters in the assessment of functionally significant coronary stenosis; results of an independent, blinded comparison with fractional flow reserve. (23890849)
2013
4
Isolated nondominant right coronary stenosis: clinical presentation and management. (23162008)
2013
5
Impact of tissue characteristics on luminal narrowing of mild angiographic coronary stenosis: assessment of integrated backscatter intravascular ultrasound. (24154856)
2013
6
The exercise treadmill test: predictors of true presence of significant coronary stenosis in patients with severe ST-segment depression. (22870737)
2012
7
Association between rs4673 (C/T) and rs13306294 (A/G) haplotypes of NAD(P)H oxidase p22phox gene and severity of stenosis in coronary arteries. (22410402)
2012
8
Risk factors for myocardial infarction with normal coronary arteries and myocarditis compared with myocardial infarction with coronary artery stenosis. (22210737)
2012
9
Improved detection of acute myocardial infarction in patients with chest pain and significant left main stem coronary stenosis. (21890878)
2012
10
Diagnostic performance of combined noninvasive anatomic and functional assessment with dual-source CT and adenosine-induced stress dual-energy CT for detection of significant coronary stenosis. (22357990)
2012
11
Evaluation of coronary stenosis with the aid of quantitative image analysis in histological cross sections. (23084314)
2012
12
Importance of diffuse atherosclerosis in the functional evaluation of coronary stenosis in the proximal-mid segment of a coronary artery by myocardial fractional flow reserve measurements. (21624549)
2011
13
A self-expandable coronary stent system to treat complex coronary stenosis complicated by poststenotic aneurysm: an optical coherence tomographic evidence-based case report. (22147408)
2011
14
Percutaneous coronary intervention for left main trunk ostial stenosis in a patient with Takayasu's arteritis. (24122503)
2011
15
N-terminal pro-B-type natriuretic peptide and diastolic function measurements by adenosine stress echocardiography in prediction of coronary stenosis in patients. (21933607)
2011
16
Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease. (21785745)
2011
17
Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model. (21094698)
2011
18
Accuracy of dual-source computed tomography in quantitative assessment of low density coronary stenosis--a motion phantom study. (19727745)
2010
19
Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis. (19416961)
2009
20
Evaluation of intermediate coronary stenosis with intravascular ultrasound and fractional flow reserve: Its use and abuse. (19133668)
2009
21
Thoracic aortic arteriosclerosis in patients with degenerative aortic stenosis with and without coexisting coronary artery disease. (18154793)
2008
22
Dual SPECT imaging with Tc-99m pyrophosphate and Tl-201 of circumferential subendocardial myocardial infarction in aortic stenosis without coronary artery stenosis. (18496451)
2008
23
Coronary stenosis treated by percutaneous angioplasty in a patient with dermatomyositis. (18319234)
2008
24
The value of percutaneous coronary intervention in aortic valve stenosis with coronary artery disease. (17275462)
2007
25
Real-time myocardial contrast dobutamine stress echocardiography in coronary stenosis. (16338011)
2006
26
Intravascular ultrasound for the assessment of an ambiguous left main coronary stenosis. (16325057)
2005
27
Anomalous origin of the right coronary artery from the pulmonary artery combined with aortic valve stenosis. (15620981)
2005
28
Inflammatory response and re-stenosis after percutaneous coronary intervention in heart transplant recipients and patients with native atherosclerosis. (16102437)
2005
29
Comparison of lumens of intermediate coronary stenosis using 16-slice computed tomography versus intravascular ultrasound. (16098305)
2005
30
Successful repair of supravalvular aortic stenosis with ostial stenosis of the left coronary artery using Brom's three patch technique. (14650592)
2003
31
Microvascular adaptation to coronary stenosis in the rat heart in vivo: a serial magnetic resonance imaging study. (14609522)
2003
32
Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats. (11864928)
2002
33
Functional assessment of coronary stenosis: it does make sense, but why don't I do it more often? (10681477)
2000
34
Isolated left coronary ostial stenosis as a result of fibromuscular dysplasia in a young man. (11194297)
2000
35
Transesophageal Echocardiographic Diagnosis of Coronary Stenosis in a Stroke Patient. (11175195)
1999
36
Treatment of Coronary Stenosis Complicated by a Saccular Aneurysm with Stenting. (10973346)
1998
37
Unusual case of coronary stenosis caused by an external compression. (9431869)
1997
38
Evaluation of intramyocardial coronary blood flow waveform during intraaortic balloon pumping in the absence or presence of coronary stenosis. (8712964)
1996
39
Supravalvular aortic stenosis, pulmonary artery stenosis, and coronary artery stenosis in twins. (8833501)
1996
40
Restenosis after coronary angioplasty for rapidly progressive coronary stenosis. (8922915)
1996
41
Assessing coronary stenosis: by which method and for what purpose? (8869850)
1996
42
Effect of critical coronary stenosis on regional function of a segment remote from the acute ischemic bed. (7952405)
1994
43
Streptokinase induced defibrination assessed by thrombin time: effects on residual coronary stenosis and left ventricular ejection fraction. (1389732)
1992
44
Revascularization with bilateral internal thoracic artery grafts in patients with left main coronary stenosis. (1581083)
1992
45
Partial coronary stenosis is sufficient and complete reperfusion is mandatory for preconditioning the canine heart. (1394878)
1992
46
Optimal criteria for rapid detection of myocardial reperfusion by creatine kinase MM isoforms in the presence of residual high grade coronary stenosis. (2794267)
1989
47
Percent coronary stenosis: battered gold standard, pernicious relic or clinical practicality? (3351158)
1988
48
Comparison of coronary stenosis quantitation results from on-line digital and digitized cine film images. (3046284)
1988
49
The effect of an increase in heart rate on remote myocardial blood flow in a two vessel coronary stenosis-occlusion model. (3594295)
1987
50
Systolic and diastolic coronary arterial blood flow in experimental valvular and supravalvular aortic stenosis. (5384330)
1969

Genetic Variations for Coronary Stenosis

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Expression for genes affiliated with Coronary Stenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coronary Stenosis

Search GEO for disease gene expression data for Coronary Stenosis.

Pathways for genes affiliated with Coronary Stenosis

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB
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Pathways related to Coronary Stenosis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0LPA, APOB, CETP
210.0OLR1, APOA1, ADIPOQ
310.0APOA1, SCARB1, SOD3
410.0APOB, ADIPOQ, CETP
510.0APOA1, APOB, LPA
610.0APOB, LPA, SELP
79.9COL3A1, APOA1, APOB
89.9SCARB1, APOB, APOA1
99.9APOB, SCARB1, APOA1
109.9APOB, APOA1, SCARB1
119.9TLR4, ITGAL, PECAM1
12
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9.9PECAM1, SELP, OLR1, FGA
13
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9.9FGA, SELP, PECAM1, APOA1
149.9SOD3, CETP, APOB, ADIPOQ
159.8SCARB1, APOB, SOD3, APOA1
16
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9.8COL3A1, FGA, ITGAL, PECAM1
17
Hide members
9.7SCARB1, APOA1, COL3A1, APOB
18
Hide members
9.7LPA, APOB, APOA1, SCARB1, CETP
19
Hide members
9.6APOA1, APOB, SCARB1, LIPC, CETP
209.6SELP, OLR1, ITGAL, APOB, PECAM1
21
Hide members
9.2PON1, LIPC, LPA, SCARB1, APOB, APOA1
22
Hide members
9.1COL3A1, CCL11, HTR2A, APOA1, APOB, ITGAL

Compounds for genes affiliated with Coronary Stenosis

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Coronary Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1uric acid44 2411.5PIK3C2A, SOD3
2alpha tocopherol4410.4ITGAL, SCARB1
3superoxide44 2411.2LPA, ITGAL, OLR1, SOD3
4estrogen4410.2LPA, ADAMTSL1, CETP, LIPC
5acipimox44 2811.0APOB, ADIPOQ, CETP, APOA1
6glucose4410.0APOA1, SCARB1, PIK3C2A, LPA, OLR1
7probucol44 1111.0CETP, SCARB1, APOB, APOA1, LIPC
8ezetimibe44 1111.0SCARB1, APOA1, ADIPOQ, APOB, CETP
9warfarin44 49 11 2412.9PIK3C2A, LPA, FGA, SELP
10dextran sulfate449.9SELP, APOB, CETP, ADAMTSL1, APOA1
11niacin44 1110.9SCARB1, LPA, CETP, APOB, APOA1, ADIPOQ
12aspartate449.8PIK3C2A, APOA1, COL3A1, CETP, ADAMTSL1
13h2o2449.8ADIPOQ, ADAMTSL1, PON1, ITGAL, PECAM1, LPA
14cholesterol ester449.8CETP, LIPC, PON1, LPA, APOB, APOA1
15gemfibrozil44 28 1111.7LPA, LIPC, CETP, PON1, APOA1, APOB
16pioglitazone44 49 28 1112.7SCARB1, SOD3, APOB, ADIPOQ, OLR1, LIPC
17bezafibrate44 28 1111.7CETP, ADIPOQ, LPA, PIK3C2A, APOB, APOA1
18ascorbic acid44 2410.7PON1, ADIPOQ, SOD3, PIK3C2A, OLR1, CETP
19phosphatidylcholine449.7APOA1, SCARB1, LIPC, APOB, CETP, PON1
20triacylglycerol449.7CETP, LIPC, APOB, APOA1, ADIPOQ
21fluvastatin44 49 28 1112.6PON1, CETP, SELP, PIK3C2A, APOB, APOA1
22carbohydrates449.6TLR4, SCARB1, LIPC, CETP, ADIPOQ, SELP
23prostacyclin449.6SELP, ADAMTSL1, FGA, PIK3C2A, APOA1, PECAM1
24malondialdehyde449.6FGA, LPA, PIK3C2A, SOD3, PON1
25intralipid449.5CETP, LIPC, APOB, APOA1
26vitamin a44 11 2411.5LIPC, APOA1, APOB, SCARB1, ADIPOQ, LPA
27thyroxine44 2410.5APOA1, LPA, APOB, PON1, LIPC, ADIPOQ
28serine449.5LIPC, TLR4, ADIPOQ, PECAM1, FGA, CETP
29lovastatin44 49 59 28 1113.5LPA, ITGAL, PIK3C2A, APOB, LIPC, PON1
30sterol449.5LIPC, CETP, ADIPOQ, SCARB1, APOB, APOA1
31homocysteine44 2410.5SOD3, APOA1, APOB, ADIPOQ, CETP, SELP
32creatinine449.4APOA1, APOB, LPA, PON1, PIK3C2A, SELP
33acetylcholine44 49 28 11 2413.4ADIPOQ, FGA, PON1, PIK3C2A, TLR4, APOA1
34fatty acid449.3APOB, SCARB1, PIK3C2A, LPA, LIPC, ADIPOQ
35arginine449.2PIK3C2A, LIPC, SOD3, CETP, SELP, ADIPOQ
36pravastatin44 49 28 11 2413.2ITGAL, LPA, PIK3C2A, OLR1, SELP, CETP
37vegf449.2SELP, ADAMTSL1, APOB, LPA, PIK3C2A, SOD3
38cysteine449.1TLR4, SELP, PECAM1, OLR1, PON1, ITGAL
39nitric oxide44 11 2411.1OLR1, PECAM1, SOD3, CCL11, TLR4, SELP
40fenofibrate44 49 1111.1ADIPOQ, CETP, SELP, OLR1, PON1, LIPC
41cyclosporin a44 28 5911.1CETP, ADAMTSL1, PIK3C2A, ITGAL, CCL11, LIPC
42phospholipid449.1ADIPOQ, ADAMTSL1, CETP, PECAM1, PON1, LIPC
43alanine448.9CCL11, CETP, PON1, ADIPOQ, ITGAL, PIK3C2A
44atorvastatin44 49 28 11 2412.8APOB, SCARB1, PIK3C2A, LPA, LIPC, PON1
45simvastatin44 49 59 28 11 2413.8CETP, SELP, OLR1, TLR4, APOA1, APOB
46heparin44 28 11 2411.8SOD3, LPA, ITGAL, PON1, FGA, PECAM1
47fibrinogen448.6TLR4, ADIPOQ, ADAMTSL1, PECAM1, APOA1, APOB
48aspirin44 49 28 2411.6CCL11, TLR4, APOA1, APOB, SCARB1, LPA
49lipid448.1FGA, OLR1, PECAM1, CETP, ADAMTSL1, ADIPOQ
50cholesterol44 28 11 2411.0ADIPOQ, LPA, ITGAL, LIPC, PON1, FGA

GO Terms for genes affiliated with Coronary Stenosis

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16Gene Ontology
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Cellular components related to Coronary Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:07168210.1APOB, APOA1
2platelet alpha granule membraneGO:03109210.1SELP, PECAM1
3high-density lipoprotein particleGO:03436410.0LIPC, CETP, PON1, APOA1
4spherical high-density lipoprotein particleGO:0343669.9PON1, APOA1
5external side of plasma membraneGO:0098979.7FGA, SELP, TLR4, ITGAL
6extracellular regionGO:0055769.1ADIPOQ, CETP, OLR1, FGA, PON1, LPA
7extracellular spaceGO:0056158.8ADIPOQ, SELP, FGA, PON1, LIPC, APOB
8plasma membraneGO:0058868.6TLR4, HTR2A, APOA1, APOB, SCARB1, OLR1

Biological processes related to Coronary Stenosis according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1cholesterol importGO:07050810.5SCARB1, APOA1
2lipoprotein biosynthetic processGO:04215810.5APOB, APOA1
3very-low-density lipoprotein particle remodelingGO:03437210.4LIPC, CETP
4positive regulation of platelet activationGO:01057210.4SELP, TLR4
5negative regulation of heterotypic cell-cell adhesionGO:03411510.4ADIPOQ, APOA1
6high-density lipoprotein particle clearanceGO:03438410.4APOA1, SCARB1
7phosphatidylcholine metabolic processGO:04647010.4CETP, PON1
8detection of lipopolysaccharideGO:03249710.4SCARB1, TLR4
9cholesterol transportGO:03030110.4APOA1, APOB, CETP
10low-density lipoprotein particle remodelingGO:03437410.4LIPC, APOB, CETP
11negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.3ADIPOQ, APOA1
12positive regulation of cholesterol storageGO:01088610.3APOB, SCARB1
13receptor-mediated endocytosisGO:00689810.3APOB, LPA, CETP
14phospholipid transportGO:01591410.3CETP, SCARB1
15leukocyte cell-cell adhesionGO:00715910.3ITGAL, SELP, OLR1
16low-density lipoprotein particle clearanceGO:03438310.3SCARB1, APOB, ADIPOQ
17cholesterol effluxGO:03334410.3APOB, SCARB1, APOA1
18phospholipid homeostasisGO:05509110.3APOA1, CETP
19platelet degranulationGO:00257610.2PECAM1, SELP, FGA, APOA1
20blood vessel endothelial cell migrationGO:04353410.2APOA1, SCARB1
21high-density lipoprotein particle remodelingGO:03437510.2SCARB1, APOA1, CETP, LIPC
22reverse cholesterol transportGO:04369110.2APOA1, CETP, SCARB1, LIPC
23triglyceride homeostasisGO:07032810.2LIPC, SCARB1, CETP, APOA1
24positive regulation of cholesterol effluxGO:01087510.2PON1, ADIPOQ
25cholesterol metabolic processGO:00820310.1APOB, LIPC, PON1, CETP, APOA1
26platelet activationGO:03016810.1FGA, COL3A1, APOA1, SELP, PECAM1
27cholesterol homeostasisGO:04263210.0APOB, SCARB1, LIPC, CETP, APOA1
28endothelial cell proliferationGO:00193510.0APOA1, SCARB1
29leukocyte migrationGO:05090010.0PECAM1, SELP, OLR1, ITGAL, APOB
30lipoprotein metabolic processGO:0421579.9APOA1, APOB, CETP, OLR1, LPA, SCARB1
31cell adhesionGO:0071559.9SELP, ITGAL, PECAM1, SCARB1, CCL11
32negative regulation of macrophage derived foam cell differentiationGO:0107459.9CETP, ADIPOQ
33inflammatory responseGO:0069549.8SELP, ITGAL, CCL11, OLR1
34blood coagulationGO:0075969.7PECAM1, ITGAL, APOB, FGA, APOA1, OLR1

Molecular functions related to Coronary Stenosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1phospholipid transporter activityGO:00554810.2APOA1, CETP
2cholesterol transporter activityGO:01712710.2APOB, APOA1, CETP
3lipopolysaccharide receptor activityGO:00187510.1TLR4, SCARB1
4low-density lipoprotein particle bindingGO:03016910.1SCARB1, LIPC
5apolipoprotein bindingGO:03418510.1LIPC, LPA, SCARB1
6lipopolysaccharide bindingGO:00153010.1SELP, SCARB1, TLR4
7high-density lipoprotein particle bindingGO:00803510.0APOA1, SCARB1
8heparin bindingGO:0082019.9APOB, SELP, LPA, SOD3, LIPC
9sialic acid bindingGO:0336919.8ADIPOQ, SELP

Products for genes affiliated with Coronary Stenosis

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Sources for Coronary Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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39NCIt
40NDF-RT
43NINDS
44Novoseek
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50PubMed
51QIAGEN
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