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MCID: CRN030

Coronary Stenosis malady
20 genes, 4 tissues, 139 related diseases, clinical trials.

Summaries for Coronary Stenosis

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MalaCards: Coronary Stenosis, also known as coronary artery stenosis, is related to obesity and pneumonia. An important gene associated with Coronary Stenosis is OLR1 (oxidized low density lipoprotein (lectin-like) receptor 1), and among its related pathways are Lipoprotein metabolism and Statin Pathway, Pharmacodynamics. The compounds vegf and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and heart, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Coronary Stenosis

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8Disease Ontology, 10DISEASES, 41Novoseek, 56UMLS, 36NCIt, 31MeSH, 52SNOMED-CT
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Aliases & Descriptions:

coronary stenosis 8 10 41 56
coronary artery stenosis 8



External Ids:

Disease Ontology8 DOID:4248
SNOMED-CT52 233970002

Related Diseases for Coronary Stenosis

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16GeneCards, 17GeneDecks
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Diseases related to coronary stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1obesity29.1PON1, LIPC, CETP, LPA, HTR2A, APOB
2pneumonia28.4CCL11, TLR4, SOD3, FGA, PIK3C2A
3acute myocardial infarction28.2LPA, FGA, SELP, OLR1, SOD3, PON1
4coronary heart disease27.5ITGAL, PECAM1, LPA, FGA, LIPC, SELP
5myocardial infarction27.3ADIPOQ, SELP, LIPC, ADAMTSL1, FGA, LPA
6atherosclerosis25.7PECAM1, LPA, FGA, LIPC, SELP, OLR1
7diabetic retinopathy13.9PON1
8hepatitis13.9CCL11
9alcoholism13.8HTR2A
10protein s deficiency13.8FGA
11pancreatitis13.8SELP
12ovarian cancer13.8FGA
13infertility13.8PON1
14colorectal cancer13.8SELP
15growth hormone deficiency13.8ADIPOQ
16xanthomatosis13.7APOB
17periodontitis13.7TLR4
18neuropathy13.7PIK3C2A
19acute pancreatitis13.7TLR4
20sarcoidosis13.6SELP, CCL11
21familial atrial fibrillation13.6SELP, FGA
22amyotrophic lateral sclerosis13.6ADAMTSL1, PON1
23dermatitis13.6CCL11, PIK3C2A
24lipodystrophy13.6APOB, ADIPOQ
25acromegaly13.6ADIPOQ, LPA
26abetalipoproteinemia13.5APOA1, APOB
27strawberry gallbladder13.5APOB, APOA1
28arteriosclerosis obliterans13.5ADIPOQ, SELP
29thromboembolism13.5SELP, APOA1, FGA
30carotid artery disease13.5PON1, APOB
31hepatitis c13.5TLR4, PON1
32adenocarcinoma13.5ADAMTSL1, PECAM1
33quebec platelet disorder13.5ADAMTSL1
34hyperuricemia13.5APOB, PIK3C2A
35cerebral infarction13.5SELP, FGA, LPA
36intermittent claudication13.5SELP, HTR2A
37anorexia nervosa13.5HTR2A, ADIPOQ
38arcus senilis13.5APOA1, APOB
39osteoarthritis13.5ADAMTSL1, OLR1, PECAM1
40carotid stenosis13.5PON1, SELP
41ipex syndrome13.5CCL11, ITGAL
42hypertension13.5APOB, APOA1, LPA
43glucose intolerance13.5ADIPOQ, APOB
44familial combined hyperlipidemia13.5APOB, APOA1
45migraine without aura13.5ITGAL, HTR2A
46hypercholesterolemia, autosomal dominant13.5APOB, CETP
47peritonitis13.5COL3A1, PECAM1, SELP
48vascular disease13.5PIK3C2A, SELP, SOD3
49mitral valve stenosis13.5SELP, FGA
50liver cirrhosis13.4FGA, CETP, ADIPOQ

Graphical network of the top 20 diseases related to coronary stenosis:



Diseases related to coronary stenosis

Symptoms for Coronary Stenosis

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Drugs & Therapeutics for Coronary Stenosis

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5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 56UMLS, 37NDF-RT
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Approved drugs:

Search CenterWatch for coronary stenosis

Drug clinical trials:

Search ClinicalTrials for coronary stenosis

Search NIH Clinical Center for coronary stenosis

Search CenterWatch for coronary stenosis

Genetic Tests for Coronary Stenosis

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Anatomical Context for Coronary Stenosis

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29MalaCards
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MalaCards organs/tissues related to coronary stenosis:

29
Brain, Heart, Monocytes, Endothelial

Animal Models for Coronary Stenosis or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to coronary stenosis:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
liver/biliary system phenotype
MP:00053709.9TLR4, FGA, COL3A1
2
hematopoietic system phenotype
MP:00053979.2FGA, ITGAL, PIK3C2A, CCL11, ADIPOQ, TLR4
3
cardiovascular system phenotype
MP:00053858.6PON1, TLR4, OLR1, SELP, FGA, PECAM1
4
immune system phenotype
MP:00053878.2SELP, OLR1, SOD3, TLR4, FGA, PECAM1
5
homeostasis/metabolism phenotype
MP:00053767.9ADIPOQ, PON1, TLR4, SOD3, OLR1, SELP

Publications for Coronary Stenosis

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47PubMed
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Articles related to coronary stenosis:

(show all 20)
idTitleAuthorsYearAffiliating Genes
1Association of three polymorphisms of scavenger recept or class BI gene (exon8, exon1, intron5) with coronary stenosis in a coronary Tu nisian population. (23041084)Rejeb J.... Bouslama A.2012SCARB1
2Four polymorphisms of cholesteryl ester transfer prote in gene and coronary stenosis in a Tunisian population. (22854712)Rejeb J.... Bouslama A.2012CETP
3Effect of apolipoprotein E genotypes on incidence and development of coronary stenosis in Iranian patients with coronary artery dise ase. (21254242)Fallah S.... Samadirad B.2011APOE
4Functional polymorphism rs189037 in the promoter regio n of ATM gene is associated with angiographically characterized coronary stenosi s. (21937043)Li S.... Mo X.2011ATM
5Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US. (19130178)Lai S.... Detrick B.2009IL6
6Interleukin 6 plasma levels predict with high sensitivity and specificity coronary stenosis detected by coronary angiography. (18064337)Noto D.... Rocco Averna M.2007IL6
7The relationship between plasma C-reactive protein levels and presence and severity of coronary stenosis in patients with stable angina. (18216376)Ulucay A.... Celik H.2007CRP
8Predictive value of lipoprotein (a) and apolipoprotein A1 in patients with angiographycally evaluated coronary stenosis (17524316)Sagastagoitia J.D.... Iriarte J.A.2007APOA1
9Cholesteryl ester transfer protein gene polymorphisms and severity of coronary stenosis. (16553359)Kolovou G.D.... Cokkinos D.V.2006CETP
10Interaction between Chlamydia pneumoniae seropositivity, inflammation and risk factors for atherosclerosis in patients with severe coronary stenosis. (17000560)Yavuz M.T.... Coskun A.2006IL6
11Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions. (17101559)Hernesniemi J.... Karhunen P.J.2006TLR4
12Associations of plasma C-reactive protein levels with the presence and extent of coronary stenosis in patients with stable coronary artery disease. (15585215)Taniguchi H.... Ohsuzu F.2005CRP
13Noninvasive myocardial endothelial intervention in the persistence of coronary stenosis: a concept of myocardial endothelial nitric oxide activator through heart failure research on clinical demand. (16555626)Yaoita H.... Maruyama Y.2005NOS3
14The 4G-allele of the PAI-1 gene is not consistently associated with a higher prevalence of coronary stenosis. (15333048)Ter Bogt N.C.... Verhoef P.2004SERPINE1
15Increased expression of monocyte CD11a and intracellular adhesion molecule-1 in patients with initial atherosclerotic coronary stenosis. (14695458)Kawamura A.... Saku K.2004ICAM1, ITGAL
16Relationship between brain natriuretic peptide and coronary stenosis: influence of aging (15067799)Suzuki N.... Yano K.2004NPPB
17Elevated level of plasma C-reactive protein in patients with unstable angina: its relations with coronary stenosis and lipid profile. (12025913)Li J.J.... Li G.S.2002CRP
18Ehlers-Danlos syndrome type IV with a unique point mutation in COL3A1 and familial phenotype of myocardial infarction without organic coronary stenosis. (11168790)Nishiyama Y.... Katayama Y.2001COL3A1
19Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis. (7697839)Ludwig E.... Ward R.H.1995ACE
20Role of coronary vasospasm in the pathogenesis of myo cardial infarction: study in patients with no significant coronary stenosis. (8249786)Fukai T.... Takeshita A.1993PIK3C2A

Variations for Coronary Stenosis

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Expression for genes affiliated with Coronary Stenosis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Coronary Stenosis

Pathways for genes affiliated with Coronary Stenosis

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50Reactome, 46PharmGKB, 34NCBI BioSystems Database, 27KEGG, 12EMD Millipore
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Pathways related to coronary stenosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Lipoprotein metabolism50
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10.3CETP
2
Statin Pathway, Pharmacodynamics46
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10.3APOA1
3
Degradation of newly synthesized ApoB-4850
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10.1PECAM1, APOB
4
PPAR signaling pathway27
10.0OLR1, APOA1, ADIPOQ
5
Selenium Pathway34
10.0APOB, APOA1, SOD3
6
LDL-mediated lipid transport50
9.9CETP, APOB, LPA
7
Selected targets of HNF112
9.9LPA, APOA1, APOB
8
Selected targets of C/EBPalpha12
9.9CETP, ADIPOQ, APOB
9
amb2 Integrin signaling34
9.9APOB, LPA, SELP
10
Platelet degranulation 50
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9.8APOA1, PECAM1, FGA, SELP
11
Selected targets of C/EBPbeta12
9.8CETP, ADIPOQ, APOB, SOD3
12
ECM-receptor interaction27
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9.7COL3A1, ITGAL, PECAM1, FGA
13
Malaria27
9.7TLR4, SELP, PECAM1, ITGAL
14
Cell surface interactions at the vascular wall50
9.5APOB, ITGAL, PECAM1, SELP, OLR1
15
Platelet activation, signaling and aggregation50
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9.2OLR1, SELP, FGA, PECAM1, ITGAL, APOA1
16
Signaling by GPCR50
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9.0FGA, HTR2A, PECAM1, ITGAL, APOA1, APOB

Compounds for genes affiliated with Coronary Stenosis

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41Novoseek, 11DrugBank, 22HMDB, 55Tocris Bioscience, 46PharmGKB
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Compounds related to coronary stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1vegf4110.1PIK3C2A, SELP, LPA
2heparin41 11 2212.1SELP, ITGAL, ADAMTSL1, CETP
3acipimox4110.1CETP, ADIPOQ, APOA1, APOB
4prostacyclin4110.0ADAMTSL1, APOA1, PIK3C2A, FGA
5sarpogrelate4110.0SELP, HTR2A, ADIPOQ
6intralipid4110.0APOB, LIPC, CETP, APOA1
7niacin41 1110.9APOA1, APOB, ADIPOQ, CETP, LPA
8orlistat41 55 1111.9APOB, LIPC, PON1, ADIPOQ
9dextran sulfate419.9APOB, CETP, APOA1, ADAMTSL1, SELP
10probucol41 1110.8APOA1, LIPC, CETP, APOB
11pioglitazone41 1110.8APOB, APOA1, LIPC, OLR1, SOD3, ADIPOQ
12cholesterol ester419.8PON1, CETP, APOB, APOA1, LPA, LIPC
13cysteine419.8LPA, OLR1, SOD3, PECAM1, ADAMTSL1, CETP
14warfarin41 46 11 2212.8SELP, FGA, APOB, PIK3C2A, LPA
15malondialdehyde419.8SOD3, FGA, LPA, PIK3C2A, PON1
16alpha tocopherol419.8PON1, SOD3, ITGAL, APOA1, APOB, CETP
17triacylglycerol419.7CETP, LIPC, APOB, ADIPOQ, APOA1
18superoxide41 2210.7PIK3C2A, SOD3, OLR1, LIPC, LPA, PECAM1
19fucoidan419.7PECAM1, ADAMTSL1, OLR1, SELP
20ptca419.6SELP, ADAMTSL1, PIK3C2A, FGA
21ascorbic acid41 2210.6OLR1, PIK3C2A, APOA1, SOD3, CETP, ADIPOQ
22vitamin a41 11 2211.6APOB, LPA, LIPC, APOA1, CETP, ADIPOQ
23gemfibrozil41 1110.6PON1, LIPC, LPA, PIK3C2A, CETP, APOA1
24uric acid41 2210.5APOA1, ADIPOQ, PIK3C2A, LPA, APOB, SOD3
25bezafibrate41 1110.5APOA1, PIK3C2A, ADIPOQ, LIPC, APOB, CETP
26fibrinogen419.5ADIPOQ, ADAMTSL1, PIK3C2A, PECAM1, LPA, LIPC
27fluvastatin41 46 1111.5APOA1, CETP, PON1, SELP, ITGAL, APOB
28acetylcholine41 11 2211.4PIK3C2A, APOA1, FGA, PON1, ADIPOQ, TLR4
29thyroxine41 2210.4LPA, CETP, PIK3C2A, APOA1, APOB, ADIPOQ
30lovastatin41 46 55 1112.3LPA, LIPC, PON1, CETP, APOB, APOA1
31homocysteine41 2210.3CETP, LPA, APOB, APOA1, PIK3C2A, ADIPOQ
32creatinine419.2APOB, APOA1, ADIPOQ, SELP, FGA, PON1
33phosphatidylcholine419.1LPA, APOA1, LIPC, APOB, CETP, PON1
34arginine419.1OLR1, SELP, SOD3, PON1, PIK3C2A, ADIPOQ
35aspartate419.1ADIPOQ, ADAMTSL1, PIK3C2A, TLR4, CETP, COL3A1
36fenofibrate41 1110.1LIPC, LPA, PIK3C2A, APOA1, APOB, ADIPOQ
37phospholipid419.1PECAM1, OLR1, TLR4, PON1, APOB, LIPC
38phosphoinositide419.0PIK3C2A, CCL11, PECAM1, HTR2A, ADAMTSL1, ADIPOQ
39pravastatin41 46 11 2212.0CETP, ADIPOQ, APOB, APOA1, PON1, OLR1
40estrogen419.0PON1, LIPC, CETP, ADIPOQ, ADAMTSL1, APOB
41alanine418.9PON1, ADIPOQ, CCL11, APOB, APOA1, PIK3C2A
42h2o2418.9PON1, TLR4, LPA, PECAM1, ADIPOQ, ADAMTSL1
43cyclosporin a41 559.9ITGAL, PIK3C2A, CCL11, COL3A1, ADAMTSL1, CETP
44atorvastatin41 46 11 2211.8LIPC, APOA1, APOB, ADIPOQ, CETP, PIK3C2A
45simvastatin41 46 55 11 2212.8PON1, TLR4, OLR1, SELP, LPA, ITGAL
46serine418.6TLR4, SOD3, LIPC, FGA, PECAM1, ITGAL
47aspirin41 46 2210.5PON1, TLR4, SELP, FGA, LPA, PECAM1
48glucose418.5LIPC, ADAMTSL1, ADIPOQ, PON1, APOB, TLR4
49lipid417.9PIK3C2A, ITGAL, PECAM1, FGA, LIPC, OLR1
50cholesterol41 11 229.9APOA1, PIK3C2A, ITGAL, PECAM1, LPA, FGA

GO Terms for genes affiliated with Coronary Stenosis

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15Gene Ontology
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Cellular components related to coronary stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spherical high-density lipoprotein particleGO:03436610.1APOA1, PON1
2high-density lipoprotein particleGO:0343649.9PON1, LIPC, APOA1, CETP
3platelet alpha granule membraneGO:0310929.8PECAM1, SELP
4external side of plasma membraneGO:0098979.6TLR4, SELP, FGA, ITGAL
5extracellular regionGO:0055768.8PON1, OLR1, FGA, LPA, APOA1, APOB
6extracellular spaceGO:0056158.5CETP, PON1, SOD3, SELP, LIPC, FGA

Biological processes related to coronary stenosis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:04215810.3APOA1, APOB
2high-density lipoprotein particle remodelingGO:03437510.3LIPC, APOA1, CETP
3reverse cholesterol transportGO:04369110.3CETP, APOA1, LIPC
4cholesterol transportGO:03030110.3APOA1, APOB, CETP
5low-density lipoprotein particle remodelingGO:03437410.3LIPC, APOB, CETP
6triglyceride homeostasisGO:07032810.3LIPC, APOA1, CETP
7negative regulation of heterotypic cell-cell adhesionGO:03411510.3APOA1, ADIPOQ
8positive regulation of platelet activationGO:01057210.3TLR4, SELP
9negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.2APOA1, ADIPOQ
10very-low-density lipoprotein particle remodelingGO:03437210.2LIPC, CETP
11leukocyte cell-cell adhesionGO:00715910.2ITGAL, SELP, OLR1
12receptor-mediated endocytosisGO:00689810.1CETP, APOB, LPA
13positive regulation of cholesterol effluxGO:01087510.1ADIPOQ, PON1
14cholesterol homeostasisGO:04263210.1CETP, APOB, APOA1, LIPC
15platelet degranulationGO:00257610.1APOA1, PECAM1, FGA, SELP
16cholesterol metabolic processGO:00820310.1LIPC, APOA1, APOB, CETP
17phosphatidylcholine metabolic processGO:04647010.1CETP, PON1
18low-density lipoprotein particle clearanceGO:03438310.1ADIPOQ, APOB
19lipid metabolic processGO:00662910.0LPA, APOA1, APOB, CETP
20lipoprotein metabolic processGO:04215710.0CETP, APOB, APOA1, LPA, OLR1
21leukocyte migrationGO:0509009.9OLR1, SELP, PECAM1, ITGAL, APOB
22phospholipid homeostasisGO:0550919.9CETP, APOA1
23platelet activationGO:0301689.9SELP, FGA, PECAM1, APOA1, COL3A1
24blood coagulationGO:0075969.6OLR1, SELP, FGA, PECAM1, ITGAL, APOA1

Molecular functions related to coronary stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid transporter activityGO:00554810.1CETP, APOA1
2lipopolysaccharide bindingGO:00153010.1SELP, TLR4
3cholesterol transporter activityGO:01712710.0APOA1, APOB, CETP
4sialic acid bindingGO:0336919.8ADIPOQ, SELP
5heparin bindingGO:0082019.6APOB, LPA, LIPC, SELP, SOD3

Products for genes affiliated with Coronary Stenosis

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Sources for Coronary Stenosis

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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