Coronary Stenosis malady

MalaCards: Coronary Stenosis, also known as coronary artery stenosis (disorder), is related to myocardial infarction and pneumonia. An important gene associated with Coronary Stenosis is SOD3 (superoxide dismutase 3, extracellular), and among its related pathways are LDL-mediated lipid transport and Selected targets of C/EBPbeta. The compounds ascorbic acid and atenolol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and monocytes, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions:

coronary stenosis 6 8 32 43 coronary artery stenosis (disorder) 6

Diseases related to coronary stenosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 505)

id	Related Disease	Score	Top Affiliating Genes
1	myocardial infarction	30.4	APOB, APOE, OLR1, ACE
2	pneumonia	21.8	PIK3C2A, SERPINE1, FGA, IL6, APOA1, APOB
3	atherosclerosis	18.6	PIK3C2A, SELP, SERPINE1, LPA, LIPC, CETP
4	carotid artery disease	13.6	APOB, PON1
5	strawberry gallbladder	13.6	APOA1, APOB
6	arcus senilis	13.5	APOA1, APOB
7	combined hyperlipemia	13.5	LIPC, APOA1, APOB
8	benign recurrent intrahepatic cholestasis	13.4	LIPC, CETP
9	coronary artery anomaly	13.4	LPA, PON1
10	adiponectin deficiency	13.4	NOS3, ADIPOQ
11	hereditary amyloidosis	13.3	FGA, APOA1
12	lipid metabolism disorder	13.3	APOA1, APOB
13	hereditary diffuse leukoencephalopathy with spheroids	13.3	LPA, CETP, APOA1, APOB
14	mitral valve stenosis	13.3	SELP, FGA, NPPB
15	coronary artery vasospasm	13.3	HTR2A, NOS3
16	diabetic polyneuropathy	13.3	APOB, NOS3, SOD3
17	common cold	13.3	SELP, CCL11, ICAM1
18	hypofibrinogenemia	13.3	SERPINE1, FGA, APOA1
19	dermatitis herpetiformis	13.3	APOB, CCL11, ICAM1
20	central sleep apnea	13.3	NOS3, NPPB
21	allergic conjunctivitis	13.3	ITGAL, CCL11, ICAM1
22	cerebral malaria	13.2	SELP, ICAM1, ADAMTSL1
23	wheat allergic reaction	13.2	CETP, FGA, CCL11, ICAM1
24	alcohol abuse	13.2	CETP, APOA1, HTR2A, ADIPOQ
25	immune-complex glomerulonephritis	13.2	SELP, ITGAL, ICAM1
26	thrombotic thrombocytopenic purpura, acquired	13.2	SELP, SERPINE1, ADAMTSL1
27	protein c deficiency	13.2	SERPINE1, FGA, ADAMTSL1
28	leukocyte-adhesion deficiency syndrome	13.2	SELP, ITGAL, ICAM1
29	vibrio vulnificus infection	13.2	PIK3C2A, IL6
30	hypothyroidism	13.1	LPA, CETP, APOB, PON1, ADIPOQ
31	von willebrand's disease	13.1	PIK3C2A, SELP, ADAMTSL1
32	hypertensive retinopathy	13.1	ACE, ADIPOQ
33	tremor	13.1	APOA1, APOB, HTR2A, PON1
34	neuroleptic malignant syndrome	13.1	PIK3C2A, HTR2A, NPPB
35	transsexualism	13.1	LIPC, IL6, ADIPOQ
36	enuresis	13.1	HTR2A, NOS3, NPPB
37	hepatic lipase deficiency	13.1	LIPC, APOA1, APOE
38	paraneoplastic syndromes	13.1	IL6, PON1, PECAM1
39	amenorrhea	13.0	APOA1, APOB, NPPB, ADIPOQ
40	familial combined hyperlipidemia	13.0	APOA1, APOB, APOE
41	vascular dementia	13.0	LPA, APOE, PON1
42	lipoprotein glomerulopathy	13.0	APOB, APOE
43	norum disease	13.0	APOA1, APOB, APOE
44	hepatic fibrosis renal cysts mental retardation	13.0	SERPINE1, LPA, APOA1, ADIPOQ
45	familial hypertriglyceridemia	13.0	APOA1, APOB, APOE
46	cadasil	13.0	IL6, NOS3
47	pneumothorax	13.0	CCL11, COL3A1, ACE
48	malignant hyperthermia susceptibility	13.0	PIK3C2A, IL6, HTR2A
49	alzheimer disease type 2	12.9	APOB, APOE
50	diabetes, type 2	12.9	NOS3, ACE, ADIPOQ

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to coronary stenosis:

²²

MGI Mouse Phenotypes related to coronary stenosis:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.6	CCL11
2	endocrine/exocrine gland phenotype	MP:0005379	10.4	HTR2A
3	integument phenotype	MP:0010771	9.7	TLR4, COL3A1, FGA, SELP
4	skeleton phenotype	MP:0005390	9.6	PECAM1, SOD3, IL6, FGA
5	respiratory system phenotype	MP:0005388	9.4	SELP, APOE, COL3A1
6	renal/urinary system phenotype	MP:0005367	9.3	NOS3, APOE, SELP
7	immune system phenotype	MP:0005387	8.7	ADIPOQ, PECAM1, TLR4, OLR1, APOA1, IL6
8	liver/biliary system phenotype	MP:0005370	8.7	TLR4, COL3A1, NOS3, APOB, APOA1, IL6
9	tumorigenesis	MP:0002006	7.6	ADIPOQ, TLR4, ACE, ICAM1, IL6, ITGAL
10	digestive/alimentary phenotype	MP:0005381	7.3	PECAM1, TLR4, COL3A1, NOS3, HTR2A, ICAM1
11	adipose tissue phenotype	MP:0005375	7.1	ADIPOQ, TLR4, ACE, NOS3, APOE, IL6
12	vision/eye phenotype	MP:0005391	7.1	TLR4, NOS3, ICAM1, APOE, APOB, IL6
13	muscle phenotype	MP:0005369	6.8	ADIPOQ, PECAM1, NPPB, TLR4, COL3A1, NOS3
14	cellular phenotype	MP:0005384	6.1	PECAM1, PON1, TLR4, ACE, NOS3, ICAM1
15	mortality/aging	MP:0010768	5.5	ADIPOQ, SOD3, TLR4, ACE, COL3A1, NOS3
16	cardiovascular system phenotype	MP:0005385	4.7	NOS3, COL3A1, ACE, TLR4, PON1, NPPB
17	homeostasis/metabolism phenotype	MP:0005376	4.2	PIK3C2A, CRP, NOS3, COL3A1, ACE, TLR4

Articles related to coronary stenosis:

(show all 17)

id	Title	Authors	Year	Affiliating Genes
1	Effect of apolipoprotein E genotypes on incidence and development of coronary stenosis in Iranian patients with coronary artery dise ase. (21254242)	Fallah S.... Samadirad B.	2011	APOE
2	Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US. (19130178)	Lai S.... Detrick B.	2009	IL6
3	Interleukin 6 plasma levels predict with high sensitivity and specificity coronary stenosis detected by coronary angiography. (18064337)	Noto D.... Rocco Averna M.	2007	IL6
4	The relationship between plasma C-reactive protein levels and presence and severity of coronary stenosis in patients with stable angina. (18216376)	Ulucay A.... Celik H.	2007	CRP
5	Predictive value of lipoprotein (a) and apolipoprotein A1 in patients with angiographycally evaluated coronary stenosis (17524316)	Sagastagoitia J.D.... Iriarte J.A.	2007	APOA1
6	Cholesteryl ester transfer protein gene polymorphisms and severity of coronary stenosis. (16553359)	Kolovou G.D.... Cokkinos D.V.	2006	CETP
7	Interaction between Chlamydia pneumoniae seropositivity, inflammation and risk factors for atherosclerosis in patients with severe coronary stenosis. (17000560)	Yavuz M.T.... Coskun A.	2006	IL6
8	Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions. (17101559)	Hernesniemi J.... Karhunen P.J.	2006	TLR4
9	Associations of plasma C-reactive protein levels with the presence and extent of coronary stenosis in patients with stable coronary artery disease. (15585215)	Taniguchi H.... Ohsuzu F.	2005	CRP
10	Noninvasive myocardial endothelial intervention in the persistence of coronary stenosis: a concept of myocardial endothelial nitric oxide activator through heart failure research on clinical demand. (16555626)	Yaoita H.... Maruyama Y.	2005	NOS3
11	The 4G-allele of the PAI-1 gene is not consistently associated with a higher prevalence of coronary stenosis. (15333048)	Ter Bogt N.C.... Verhoef P.	2004	SERPINE1
12	Increased expression of monocyte CD11a and intracellular adhesion molecule-1 in patients with initial atherosclerotic coronary stenosis. (14695458)	Kawamura A.... Saku K.	2004	ICAM1, ITGAL
13	Relationship between brain natriuretic peptide and coronary stenosis: influence of aging (15067799)	Suzuki N.... Yano K.	2004	NPPB
14	Elevated level of plasma C-reactive protein in patients with unstable angina: its relations with coronary stenosis and lipid profile. (12025913)	Li J.J.... Li G.S.	2002	CRP
15	Ehlers-Danlos syndrome type IV with a unique point mutation in COL3A1 and familial phenotype of myocardial infarction without organic coronary stenosis. (11168790)	Nishiyama Y.... Katayama Y.	2001	COL3A1
16	Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis. (7697839)	Ludwig E.... Ward R.H.	1995	ACE
17	Role of coronary vasospasm in the pathogenesis of myo cardial infarction: study in patients with no significant coronary stenosis. (8249786)	Fukai T.... Takeshita A.	1993	PIK3C2A

Genes related to coronary stenosis according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	SOD3	superoxide dismutase 3, extracellular	11.0
2	FGA	fibrinogen alpha chain	11.0
3	OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	11.0
4	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0
5	PON1	paraoxonase 1	11.0
6	LIPC	lipase, hepatic	11.0
7	LPA	lipoprotein, Lp(a)	11.0
8	CCL11	chemokine (C-C motif) ligand 11	11.0
9	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
10	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0
11	APOA1	apolipoprotein A-I	11.0	Publications
12	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0
13	APOB	apolipoprotein B (including Ag(x) antigen)	11.0
14	ADAMTSL1	ADAMTS-like 1	11.0
15	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0
16	COL3A1	collagen, type III, alpha 1	11.0	Publications
17	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
18	IQCA1	IQ motif containing with AAA domain 1	11.0	Disorders
19	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
20	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
21	TLR4	toll-like receptor 4	11.0	Publications
22	NPPB	natriuretic peptide B	11.0	Publications
23	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
24	ICAM1	intercellular adhesion molecule 1	11.0	Publications
25	CRP	C-reactive protein, pentraxin-related	11.0	Publications
26	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
27	APOE	apolipoprotein E	11.0	Publications
28	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to coronary stenosis according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	LDL-mediated lipid transport38	10.3	CETP, LPA
2	Selected targets of C/EBPbeta10	10.2	SOD3, APOB, CETP
3	Selected targets of C/EBPalpha10	9.9	ADIPOQ, APOB, CETP
4	Cell adhesion molecules (CAMs)20	9.8	SELP, ITGAL, PECAM1
5	Selected targets of HNF110	9.6	LPA, APOA1, APOB, CRP
6	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	9.5	IL6, CCL11
7	Immune response_TLR signaling pathways41	9.4	IL6, CCL11, TLR4
8	African trypanosomiasis20	9.4	IL6, APOA1, ICAM1
9	Statin Pathway, Pharmacodynamics34	9.3	LIPC, APOA1, APOB, APOE
10	Cytokine production by Th17 cells in CF41	9.2	TLR4, ICAM1, IL6
11	Rheumatoid arthritis20	9.1	TLR4, ICAM1, IL6, ITGAL
12	Chagas disease (American trypanosomiasis)20	8.8	SERPINE1, IL6, ACE, TLR4
13	Malaria20	8.8	SELP, PECAM1, TLR4, ICAM1, IL6, ITGAL

Compounds related to coronary stenosis according to GeneDecks:

(show top 50)    (show all 232)

id	Compound	Score	Top Affiliating Genes
1	ascorbic acid32 18	11.7	OLR1
2	atenolol32 9 18 9	13.4	SERPINE1
3	pioglitazone32 9 9	11.4	LIPC, APOA1, APOB, OLR1, SOD3, NPPB
4	endotoxin32	9.4	CRP, ITGAL, FGA, ADIPOQ, CCL11
5	cholesterol ester32	8.9	LIPC, PON1, APOE, APOB, APOA1, CETP
6	dextran sulfate32	8.7	APOB, ADAMTSL1, APOA1, IL6, CETP, SELP
7	lovastatin32 42 9 9	11.6	PON1, APOE, APOB, CETP, LPA, PIK3C2A
8	aspartate32	8.5	ADAMTSL1, APOE, APOA1, PIK3C2A, SELP, CETP
9	testosterone32 9 18 9	11.5	NPPB, PIK3C2A, LIPC, CETP, APOA1, APOE
10	rosuvastatin32 34 9 9	11.5	ADIPOQ, NOS3, CRP, APOA1, IL6, CETP
11	valsartan32 42 9 9	11.5	NPPB, ACE, SERPINE1, SELP, ADIPOQ, CRP
12	sele32	8.4	ICAM1, APOE, CETP, SELP, PON1, ACE
13	gemfibrozil32 9 9	10.3	LIPC, CETP, APOA1, APOB, APOE, PON1
14	cerivastatin32 9 9	10.3	APOB, ICAM1, CRP, APOA1, SERPINE1, NOS3
15	candesartan32 9 9	10.3	NOS3, NPPB, ACE, SELP, ADIPOQ, SERPINE1
16	vitamin a32 9 18 9	11.3	ADIPOQ, LIPC, APOE, CRP, CETP, PON1
17	uric acid32 18	9.2	PIK3C2A, SERPINE1, LPA, APOA1, APOB, CRP
18	creatinine32	8.2	ADIPOQ, SELP, FGA, APOA1, APOB, CRP
19	alpha tocopherol32	8.2	APOB, CRP, ITGAL, CETP, PON1, APOA1
20	warfarin32 34 9 18 9	12.2	PIK3C2A, SELP, LPA, FGA, APOB, APOE
21	fluvastatin32 34 9 9	11.1	SELP, SERPINE1, CETP, ITGAL, IL6, APOA1
22	thyroxine32 18	9.0	CETP, ADIPOQ, NPPB, PON1, PIK3C2A, APOE
23	superoxide32 18	9.0	NPPB, ITGAL, CCL11, PIK3C2A, LPA, OLR1
24	phospholipid32	7.9	APOE, OLR1, APOB, APOA1, CETP, LIPC
25	8-isoprostane32	7.9	IL6, NPPB, SERPINE1, PON1, NOS3, CRP
26	ly29400232	7.8	IL6, ICAM1, TLR4, ADIPOQ, PIK3C2A, CRP
27	bezafibrate32 9 9	9.7	LIPC, CETP, APOA1, APOB, APOE, CRP
28	heparin32 9 18 9	10.5	PIK3C2A, SERPINE1, LPA, LIPC, CETP, ITGAL
29	losartan32 34 9 9	10.5	ADIPOQ, SOD3, ACE, CRP, OLR1, NPPB
30	acetylcholine32 9 18 9	10.2	FGA, SOD3, APOA1, APOE, CRP, NOS3
31	lactate32	7.2	SELP, IL6, CRP, TLR4, ADIPOQ, APOB
32	rosiglitazone32 9 18 9	10.1	SERPINE1, APOE, LPA, IL6, APOB, CRP
33	h2o232	7.0	ADAMTSL1, ADIPOQ, NOS3, PECAM1, PON1, TLR4
34	fenofibrate32 9 9	8.7	PIK3C2A, SELP, SERPINE1, LPA, LIPC, CETP
35	homocysteine32 18	7.6	CETP, APOA1, APOB, APOE, CRP, NOS3
36	actinomycin d32	6.6	APOE, CCL11, ICAM1, NOS3, TLR4, NPPB
37	vegf32	6.6	SELP, PIK3C2A, SERPINE1, LPA, APOB, ADAMTSL1
38	nitric oxide32 9 18 9	9.5	ITGAL, SOD3, SELP, LPA, SERPINE1, IL6
39	cyclosporin a32 42	7.5	PIK3C2A, ADAMTSL1, PECAM1, NPPB, SELP, LIPC
40	estrogen32	6.4	NOS3, NPPB, PON1, APOE, APOB, APOA1
41	alanine32	6.4	PON1, PIK3C2A, ITGAL, ADIPOQ, TLR4, CRP
42	fibrinogen32	6.2	PIK3C2A, SELP, SERPINE1, TLR4, CRP, ICAM1
43	pravastatin32 34 9 18 9	10.0	SERPINE1, ADIPOQ, NPPB, LPA, CETP, ITGAL
44	serine32	6.0	APOB, FGA, SOD3, PECAM1, TLR4, ITGAL
45	prostacyclin32	5.9	FGA, APOA1, APOE, ICAM1, CRP, NOS3
46	aspirin32 34 18	7.5	APOB, APOE, CCL11, CRP, ACE, TLR4
47	simvastatin32 34 42 9 18 9	10.4	PIK3C2A, SELP, SERPINE1, LPA, CETP, ITGAL
48	atorvastatin32 34 9 18 9	9.2	APOA1, APOB, APOE, ICAM1, OLR1, CRP
49	cholesterol32 9 18 9	7.8	SELP, SERPINE1, LPA, LIPC, CETP, APOE
50	lipid32	4.4	CRP, PON1, NPPB, PECAM1, ADAMTSL1, ADIPOQ

Cellular components related to coronary stenosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate-density lipoprotein particle	GO:034363	9.4	APOB, APOE
2	high-density lipoprotein particle	GO:034364	9.0	PON1, APOE, APOA1, CETP, LIPC
3	very-low-density lipoprotein particle	GO:034361	8.9	APOA1, APOB, APOE
4	external side of plasma membrane	GO:009897	8.4	TLR4, ACE, ICAM1, FGA, ITGAL, SELP
5	extracellular region	GO:005576	6.1	OLR1, CRP, COL3A1, PON1, NPPB, ADIPOQ
6	plasma membrane	GO:005886	5.6	HTR2A, OLR1, NOS3, ACE, TLR4, PECAM1
7	extracellular space	GO:005615	4.7	SELP, CRP, COL3A1, ACE, SOD3, PON1

Biological processes related to coronary stenosis according to GeneDecks:

(show all 39)

id	Name	GO ID	Score	Top Affiliating Genes
1	lipoprotein biosynthetic process	GO:042158	10.3	APOB, APOA1
2	low-density lipoprotein particle remodeling	GO:034374	10.3	LIPC, CETP, APOB
3	triglyceride homeostasis	GO:070328	10.2	LIPC, CETP, APOA1
4	cholesterol transport	GO:030301	10.2	CETP, APOA1, APOB
5	positive regulation of platelet activation	GO:010572	10.2	TLR4, SELP
6	negative regulation of heterotypic cell-cell adhesion	GO:034115	10.1	ADIPOQ, APOA1
7	negative regulation of hydrolase activity	GO:051346	10.1	NOS3, APOA1
8	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	GO:002291	10.1	ITGAL, ICAM1
9	negative regulation of tumor necrosis factor-mediated signaling pathway	GO:010804	9.9	ADIPOQ, APOA1
10	positive regulation of interleukin-8 production	GO:032757	9.9	ADIPOQ, TLR4, SERPINE1
11	negative regulation of macrophage derived foam cell differentiation	GO:010745	9.9	ADIPOQ, CRP, CETP
12	platelet degranulation	GO:002576	9.8	SELP, SERPINE1, FGA, APOA1, PECAM1
13	heterophilic cell-cell adhesion	GO:007157	9.8	ICAM1, ITGAL, SELP
14	leukocyte cell-cell adhesion	GO:007159	9.8	OLR1, ICAM1, ITGAL, SELP
15	negative regulation of smooth muscle cell proliferation	GO:048662	9.7	ADIPOQ, NPPB, NOS3
16	Cdc42 protein signal transduction	GO:032488	9.7	APOE, APOA1
17	very-low-density lipoprotein particle remodeling	GO:034372	9.7	APOE, CETP, LIPC
18	high-density lipoprotein particle assembly	GO:034380	9.6	APOE, APOA1
19	positive regulation of cholesterol efflux	GO:010875	9.6	APOE, PON1, ADIPOQ
20	high-density lipoprotein particle clearance	GO:034384	9.6	APOE, APOA1
21	chylomicron remnant clearance	GO:034382	9.6	APOE, LIPC
22	high-density lipoprotein particle remodeling	GO:034375	9.5	APOE, APOA1, CETP, LIPC
23	reverse cholesterol transport	GO:043691	9.5	APOE, APOA1, CETP, LIPC
24	defense response to Gram-negative bacterium	GO:050829	9.5	TLR4, IL6, SERPINE1, SELP
25	response to cytokine stimulus	GO:034097	9.5	COL3A1, NOS3, SERPINE1
26	leukocyte migration	GO:050900	9.4	PECAM1, OLR1, ICAM1, APOB, ITGAL, SELP
27	negative regulation of lipid storage	GO:010888	9.4	CRP, IL6
28	receptor-mediated endocytosis	GO:006898	9.4	APOE, APOB, CETP, LPA
29	response to ethanol	GO:045471	9.3	ICAM1, NOS3, TLR4, ADIPOQ
30	response to organic cyclic compound	GO:014070	9.3	SELP, ICAM1, NOS3, NPPB
31	cholesterol homeostasis	GO:042632	9.3	APOE, APOB, APOA1, CETP, LIPC
32	cholesterol metabolic process	GO:008203	9.3	APOE, APOB, APOA1, CETP, LIPC
33	lipid metabolic process	GO:006629	9.2	APOE, APOB, APOA1, CETP, LPA
34	lipoprotein metabolic process	GO:042157	9.1	LPA, OLR1, APOE, APOB, APOA1, CETP
35	platelet activation	GO:030168	9.1	PECAM1, COL3A1, APOA1, IL6, FGA, SERPINE1
36	negative regulation of inflammatory response	GO:050728	8.9	APOE, APOA1, ADIPOQ
37	blood coagulation	GO:007596	8.8	PECAM1, NOS3, OLR1, APOB, APOA1, FGA
38	response to hypoxia	GO:001666	8.8	ADIPOQ, NPPB, SOD3, TLR4, NOS3, CRP
39	inflammatory response	GO:006954	8.7	NPPB, CRP, OLR1, CCL11, IL6, ITGAL

Molecular functions related to coronary stenosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	sialic acid binding	GO:033691	10.0	SELP, ADIPOQ
2	cholesterol transporter activity	GO:017127	9.9	APOB, APOA1, CETP
3	eukaryotic cell surface binding	GO:043499	9.9	ADIPOQ, FGA, SELP
4	cholesterol binding	GO:015485	9.5	CRP, APOA1, CETP
5	phosphatidylcholine-sterol O-acyltransferase activator activity	GO:060228	9.2	APOA1, APOE
6	heparin binding	GO:008201	8.9	SELP, LPA, LIPC, APOB, APOE, SOD3