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MCID: CRN017

Coronary Thrombosis malady
8 drugs, 14 genes, 1 tissue, 292 related diseases, 9 phenotypes, 16 articles, clinical trials.

Summaries for Coronary Thrombosis

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44Wikipedia, 22MalaCards
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Wikipedia: Coronary thrombosis is a form of thrombosis affecting the coronary circulation. It is associated with...44 more...

MalaCards: Coronary Thrombosis, also known as coronary artery thrombosis (disorder), is related to antithrombin iii deficiency and thrombosis. An important gene associated with Coronary Thrombosis is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are Common Pathway and Immune response IL-1 signaling pathway. The drugs heparin and heparin sodium (pork) and the compounds integrilin and abciximab have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Descriptions for Coronary Thrombosis

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6Disease Ontology, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH
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Aliases & Descriptions:

coronary thrombosis 6 32 43
coronary artery thrombosis (disorder) 6

Related Diseases for Coronary Thrombosis

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13GeneCards, 14GeneDecks
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Diseases related to coronary thrombosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 289)
idRelated DiseaseScoreTop Affiliating Genes
1antithrombin iii deficiency28.4SERPINC1, FGA, F5
2thrombosis27.2VWF, SERPINC1, SERPINE1, P2RY12, ITGB3, FGA
3antiphospholipid syndrome26.3VWF, SERPINC1, SERPINE1, ITGB3, GP1BA, F5
4myocardial infarction23.1VWF, SERPINC1, SERPINE1, P2RY12, ITGB3, FGA
5type 3 von willebrand disease13.4VWF, PLAT
6intracranial embolism13.4SERPINC1, PLAT
7acute fatty liver of pregnancy13.4SERPINC1, F3
8central serous chorioretinopathy13.4SERPINE1, PLAT
9peripheral vertigo13.4SERPINC1, F3
10plasminogen activator inhibitor type 1 deficiency13.4SERPINE1, PLAT
11acquired von willebrand syndrome13.4VWF, F3
12plasminogen activator deficiency13.4SERPINE1, PLAT
13fournier gangrene13.4SERPINC1, F3
14hemarthrosis13.4VWF, F3
15achenbach syndrome13.3F3, PLAT
16type 1 von willebrand disease13.3VWF, P2RY12
17autoimmune thrombocytopenic purpura13.3VWF, ITGB3
18thromboangiitis obliterans13.3SERPINE1, PLAT
19neonatal alloimmune thrombocytopenia13.3ITGB3, POU2F3
20pseudo-von willebrand disease13.3VWF, GP1BA
21arterial occlusive disease13.2VWF, F3, PLAT
22takayasu's arteritis13.2SERPINC1, ITGB3, F3
23angiodysplasia13.2VWF, SERPINE1, F3
24infective endocarditis13.2VWF, SERPINC1, ITGB3
25peripheral vascular disease13.2VWF, SERPINE1
26thrombotic thrombocytopenic purpura, acquired13.2VWF, SERPINE1, F3
27nephrosclerosis13.2SERPINC1, SERPINE1, F3
28coronary restenosis13.2SERPINC1, SERPINE1, PLAT
29systemic lupus erythematosus, association with13.1SERPINE1, F3, PLAT
30acute myocarditis13.1FGA, PLAT
31afibrinogenemia13.1VWF, FGA, F3
32factor xii deficiency13.1F5, F3
33legg-calve-perthes disease13.1SERPINC1, F5
34postphlebitic syndrome13.1SERPINC1, F5
35placental infarction13.1SERPINC1, F5
36factor x deficiency13.1F5, F3
37prothrombin deficiency13.1SERPINC1, F5
38acquired angioedema13.1SERPINC1, F5
39spinal cord infarction13.1SERPINC1, F5
40factor v deficiency13.1F5, F3
41blood platelet disease13.0VWF, GP1BA
42familial combined hyperlipidemia13.0VWF, SERPINE1, PLAT
43acquired hemophilia13.0F5, F3
44vein disease13.0SERPINC1, F5
45amaurosis fugax13.0SERPINE1, F5
46retinal vascular occlusion13.0SERPINC1, F5
47macrothrombocytopenia13.0ITGB3, GP1BA
48neonatal stroke13.0SERPINE1, F5
49hepatic vein thrombosis13.0SERPINE1, F5
50homocysteine plasma level13.0SERPINC1, F5

Graphical network of the top 20 diseases related to coronary thrombosis:



Graphical network of diseases related to coronary thrombosis

Clinical Features for Coronary Thrombosis

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Drugs & Therapeutics for Coronary Thrombosis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for coronary thrombosis

Drug clinical trials:

Search ClinicalTrials for coronary thrombosis

Search NIH Clinical Center for coronary thrombosis

Search CenterWatch for coronary thrombosis

Inferred drug relations via UMLS/NDF-RT:

43 28 heparin, heparin calcium, heparin sodium, heparin sodium (beef lung), heparin sodium (beef), heparin sodium (pork), tenecteplase, urokinase

Genetic Tests for Coronary Thrombosis

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Anatomical Context for Coronary Thrombosis

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22MalaCards
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MalaCards organs/tissues related to coronary thrombosis:

22
Heart

Phenotypes for genes affiliated with Coronary Thrombosis

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25MGI
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MGI Mouse Phenotypes related to coronary thrombosis:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1immune system phenotypeMP:00053879.8VWF, PLAT
2hematopoietic system phenotypeMP:00053979.8GP1BA, P2RY12
3vision/eye phenotypeMP:00053918.1PLAT, PTGS2, F3, FGA, ITGB3, SERPINC1
4liver/biliary system phenotypeMP:00053708.0PTGS2, F5, FGA, ITGB3, SERPINE1, SERPINC1
5nervous system phenotypeMP:00036317.0PLAT, PTGS2, F3, F5, FGA, SERPINC1
6integument phenotypeMP:00107716.9SLC6A4, POU2F3, PTGS2, F3, F5, FGA
7cardiovascular system phenotypeMP:00053856.5SLC6A4, PLAT, PTGS2, F3, F5, FGA
8mortality/agingMP:00107686.1PTGS2, PLAT, POU2F3, SLC6A4, F3, F5
9homeostasis/metabolism phenotypeMP:00053765.3VWF, SLC6A4, PLAT, PTGS2, F3, F5

Publications for genes affiliated with Coronary Thrombosis

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35PubMed
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Articles related to coronary thrombosis:

(show all 16)
idTitleAuthorsYearAffiliating Genes
1The risk of coronary thrombosis with cyclo-oxygenase- 2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxyge nase-2 gene. (21371074)McGettigan P.... Henry D.2011PTGS2
2The von Willebrand factor antagonist (GPG-290) prevents coronary thrombosis without prolongation of bleeding time. (17721623)Wadanoli M.... Huang Q.2007VWF
3Cangrelor for treatment of coronary thrombosis. (16595568)Fugate S.E.... Cudd L.A.2006P2RY12
4Recurrent coronary thrombosis, factor V Leiden, primary antiphospholipid syndrome and HIV (15469799)Santos J.L.... MartA-n Luengo C.2004SERPINC1, F5
5Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. (15306180)Ollikainen E.... Karhunen P.J.2004GP6
6The combination of glycoprotein IIIa PlA polymorphism with polymorphism of serotonin transporter as an independent strong risk factor for the occurrence of coronary thrombosis. (12855229)Schwartz E.... Kudinov S.2003ITGB3, SLC6A4
7Platelet membrane glycoprotein Ibalpha gene -5T/C Kozak sequence polymorphism as an independent risk factor for the occurrence of coronary thrombosis. (11751671)Douglas H.... Tuddenham E.G.2002GP1BA
8Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism, coronary thrombosis, and myocardial infarction in middle-aged Finnish men who died suddenly. (10928474)Mikkelsson J.... Karhunen P.J.2000SERPINE1
9Early risk stratification of unstable angina/non-Q my ocardial infarction: biochemical markers of coronary thrombosis. (10328612)Galvani M.... Eisenberg P.R.1999FGA
10Coronary thrombosis. Effects of blood flow on the mechanism of thrombus formation. (9925990)Goto S.... Handa S.1998VWF
11Coronary thrombosis and the platelet glycoprotein IIIA gene PLA2 polymorphism. (9716140)Durante-Mangoni E.... Tuddenham E.G.1998POU2F3
12Coronary thrombosis associated with antithrombin-III deficiency. (9327319)Loubser P.G.... Attar M.1997SERPINC1
13Comparison of desulfatohirudin (REVASC) and heparin as adjuncts to thrombolytic therapy with reteplase in a canine model of coronary thrombosis. (8735626)Martin U.... Fischer S.1996PLAT, F3
14Double bolus administration of the novel recombinant plasminogen activator BM 06.022 improves coronary blood flow after reperfusion in a canine model of coronary thrombosis. (1606285)Martin U.... Strein K.1992PLAT
15Thrombolytic effects of a novel modified tissue plasminogen activator, E6010, on coronary thrombosis in the pig. (1513078)Adachi H.... Shoji T.1992PLAT
16Hypothesis: warfarin administered simultaneously with heparin infusion will prevent heparin-discontinuance associated coronary thrombosis. (2191783)Craddock L.D.... Shander D.1990SERPINC1

Expression for genes affiliated with Coronary Thrombosis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Coronary Thrombosis

Pathways for genes affiliated with Coronary Thrombosis

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38Reactome, 10EMD Millipore, 36QIAGEN, 41Thomson Reuters, 20KEGG, 34PharmGKB, 37R&D Systems
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Pathways related to coronary thrombosis according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1Common Pathway389.6F5, SERPINC1
2Immune response IL-1 signaling pathway109.3SERPINE1, F3, PTGS2
3Intrinsic Prothrombin Activation Pathway369.1SERPINC1, FGA, F5
4Immune response_IL-1 signaling pathway419.1PTGS2, F3, SERPINE1
5ECM-receptor interaction209.1VWF, ITGB3, GP1BA, GP6
6Extrinsic Prothrombin Activation Pathway369.0F3, F5, FGA, SERPINC1
7Blood Coagulation Cascade369.0F3, F5, FGA, SERPINC1
8Platelet Aggregation Inhibitor Pathway, Pharmacodynamics348.9GP6, FGA, ITGB3, P2RY12, VWF
9Complement and coagulation cascades208.2PLAT, F3, F5, FGA, SERPINE1, SERPINC1
10Blood Coagulation Signaling Pathways377.8VWF, PLAT, F3, F5, GP6, GP1BA

Compounds for genes affiliated with Coronary Thrombosis

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32Novoseek , 9DrugBank, 34PharmGKB, 18HMDB, 42Tocris Bioscience
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Compounds related to coronary thrombosis according to GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1integrilin32 10.4PLAT
2abciximab32 9 9 12.4F3, VWF
3clopidogrel32 34 9 18 9 14.2SERPINC1, P2RY12
4reviparin32 10.0PLAT, SERPINC1, F3
5efegatran32 9.9PLAT, F3, SERPINC1
6desirudin32 9.6PLAT, F3, FGA
7epsilon aminocaproic acid32 9.6PLAT, F3, SERPINE1, SERPINC1
8fucoidan32 9.6PLAT, SERPINE1, F3, SERPINC1
9inogatran32 9.5F5, SERPINC1, F3
10tranexamic acid32 9 9 11.5SERPINE1, SERPINC1, VWF, PLAT, F3
11spectrozyme32 9.4SERPINC1, F5, F3, PLAT
12fondaparinux32 9.4F3, PLAT, SERPINC1, F5
13protamine sulfate32 9.4PLAT, F3, F5, SERPINC1
14ecarin32 9.3F3, F5, SERPINC1
15tirofiban32 9 9 11.2P2RY12, ITGB3, F3, PLAT, SERPINC1, VWF
16ristocetin32 9.2VWF, SERPINC1, GP1BA, GP6, PLAT
17levonorgestrel32 9 9 11.2F3, PLAT, F5, SERPINC1
18iloprost32 42 9 9 12.2SERPINC1, F3, PTGS2, PLAT
19batroxobin32 9.2PLAT, F5, FGA, SERPINE1
20dermatan sulfate32 9.1F5, VWF, SERPINC1, F3, PLAT
21aspartate32 9.1SLC6A4, F5
22ppack32 9.1PLAT, VWF, P2RY12, FGA, F3, SERPINC1
23ticlopidine32 9 9 11.1FGA, F3, PLAT, SERPINC1, VWF, P2RY12
24hirugen32 9.0F5, SERPINC1, FGA
25bivalirudin32 9 9 11.0FGA, PLAT, F3, SERPINC1, F5
26argatroban32 9 9 11.0F3, F5, FGA, PLAT, SERPINC1
27phosphatidylserine32 9 9 11.0GP1BA, VWF, F5, GP6
28ancrod32 8.9FGA, F5, PLAT, SERPINC1, SERPINE1
29heparin32 9 18 9 11.9VWF, POU2F3, F3, FGA, P2RY12, SERPINE1
30convulxin32 8.9F5, P2RY12, GP6, GP1BA
31raloxifene32 9 9 10.8SLC6A4, SERPINC1, VWF, F5
32homocysteine32 18 9.8SERPINE1, SERPINC1, VWF, F5, F3, PLAT
33warfarin32 34 9 18 9 12.7PLAT, F3, F5, FGA, VWF, SERPINC1
34protamine32 8.7F3, SERPINE1, F5, PLAT, SERPINC1, FGA
35thromboxane32 18 9.6GP6, VWF, P2RY12, FGA, PTGS2, PLAT
36thromboxane a232 18 9.6PLAT, PTGS2, GP6, FGA, P2RY12, VWF
37pge132 8.6PLAT, FGA, F5, P2RY12, SERPINE1, VWF
38kininogen32 8.4SERPINE1, F5, VWF, GP1BA, SERPINC1, PLAT
39simvastatin32 34 42 9 18 9 13.3F5, PLAT, SLC6A4, SERPINE1, VWF, F3
40hirudin32 8.0VWF, SERPINC1, SERPINE1, PLAT, F3, F5
41aprotinin32 9 9 9.9PLAT, VWF, F3, SERPINC1, SERPINE1, FGA
42desmopressin32 42 9 9 10.9F3, F5, PTGS2, PLAT, GP1BA, SERPINE1
43creatinine32 7.7FGA, VWF, PLAT, F3, F5, GP6
44epinephrine32 9 18 9 10.5FGA, SLC6A4, F3, F5, GP1BA, GP6
45prostacyclin32 7.4PTGS2, F5, GP1BA, FGA, VWF, SERPINC1
46adp32 18 8.0F3, GP6, GP1BA, SLC6A4, PLAT, FGA
47fibrinogen32 6.9PLAT, F3, GP6, GP1BA, FGA, ITGB3
48alanine32 6.7SERPINC1, ITGB3, SLC6A4, F3, F5, GP1BA
49aspirin32 34 18 8.4VWF, SERPINC1, SERPINE1, GP6, P2RY12, ITGB3
50serine32 6.3GP6, SERPINC1, SERPINE1, VWF, FGA, SLC6A4

GO Terms for genes affiliated with Coronary Thrombosis

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12Gene Ontology
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Cellular components related to coronary thrombosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:0310919.8VWF, FGA
2extracellular matrixGO:0310129.3PLAT, F3, SERPINE1, VWF
3platelet alpha granule lumenGO:0310938.9VWF, SERPINE1, FGA, F5
4extracellular spaceGO:0056158.0PLAT, F3, F5, FGA, SERPINE1, SERPINC1
5plasma membraneGO:0058866.2SLC6A4, F3, F5, GP6, GP1BA, FGA

Biological processes related to coronary thrombosis according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:01490910.0PLAT, ITGB3
2hemostasisGO:0075999.9P2RY12, VWF
3blood coagulation, intrinsic pathwayGO:0075979.7VWF, GP1BA
4fibrinolysisGO:0427309.5SERPINE1, GP1BA, PLAT
5negative regulation of synaptic transmission, dopaminergicGO:0322279.2SLC6A4, PTGS2
6response to glucocorticoid stimulusGO:0513849.0SERPINE1, PTGS2, PLAT
7response to estradiol stimulusGO:0323558.8F3, PTGS2, SLC6A4
8platelet degranulationGO:0025768.7F5, FGA, ITGB3, SERPINE1, VWF
9platelet activationGO:0301687.4F5, GP6, GP1BA, FGA, ITGB3, P2RY12
10blood coagulationGO:0075966.7VWF, PLAT, F3, F5, GP6, GP1BA

Molecular functions related to coronary thrombosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.1VWF, SERPINC1, SERPINE1, F3
2protein bindingGO:0055155.6POU2F3, PLAT, F3, F5, GP6, GP1BA

Sources for Coronary Thrombosis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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