MCID: CRN017
MIFTS: 50

Coronary Thrombosis malady

Blood diseases category

Aliases & Classifications for Coronary Thrombosis

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 56SNOMED-CT, 33MeSH
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Aliases & Descriptions for Coronary Thrombosis:

Name: Coronary Thrombosis 8 44 61
 
Coronary Artery Thrombosis 8


Classifications:



External Ids:

Disease Ontology8 DOID:11847
MeSH33 D003328

Summaries for Coronary Thrombosis

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Wikipedia:64 Coronary thrombosis is the formation of a blood clot inside a blood vessel of the heart due to various... more...

MalaCards based summary: Coronary Thrombosis, also known as coronary artery thrombosis, is related to purpura and thrombocytosis. An important gene associated with Coronary Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and GP1b-IX-V activation signalling. The drugs heparin and heparin sodium and the compounds reviparin and integrilin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related mouse phenotypes are muscle and liver/biliary system.

Related Diseases for Coronary Thrombosis

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Diseases related to Coronary Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.3SERPINC1
2thrombocytosis30.6VWF, GP1BA, SERPINC1, F3, FGA
3coronary artery disease30.6FGA, SERPINE1, ITGB3, GP6, PLAT
4lupus erythematosus30.5F3, F5, SERPINC1
5acute myocardial infarction30.4VWF, SERPINE1, SERPINC1, F3, PLAT, SLC6A4
6antiphospholipid syndrome30.3F5, F3, PLAT, VWF, SERPINC1
7protein c deficiency30.3SERPINE1, SERPINC1, F5
8vascular disease30.2VWF, F3, PTGS2, SERPINC1
9pulmonary embolism30.1F5, PLAT, F3, SERPINC1, FGA
10protein s deficiency30.1F5, SERPINC1, FGA, SERPINE1, F3
11hyperglycemia30.0SERPINE1, SERPINF1, FGA
12disseminated intravascular coagulation29.7SERPINE1, SERPINC1, F5, PLAT, FGA, F3
13atherosclerosis29.6F3, P2RY12, SERPINC1, SERPINE1, SERPINF1, PLAT
14thrombophilia29.5VWF, SERPINE1, SERPINC1, F3, PLAT, F5
15thrombocytopenia29.3FGA, F5, ITGB3, VWF, GP6, GP1BA
16myocardial infarction29.2ITGB3, F3, SERPINC1, SERPINE1, PTGS2, GP1BA
17central retinal artery occlusion10.6PLAT
18eclampsia10.6SERPINC1
19angiodysplasia10.5VWF
20sneddon syndrome10.5SERPINC1
21intermittent claudication10.5VWF
22afibrinogenemia, congenital10.5FGA
23endophthalmitis10.4PLAT
24carotid artery thrombosis10.4SERPINE1, F3
25artery disease10.4
26hemophilia b10.4F3
27intermediate coronary syndrome10.4PLAT, SERPINC1
28macular holes10.4SERPINF1
29hemarthrosis10.4F3, VWF
30von willebrand disease, platelet-type10.4GP1BA, VWF
31branch retinal artery occlusion10.4F5
32hemorrhagic disease10.4PLAT, SERPINE1
33hemorrhage, intracerebral10.3PLAT, F3
34peripheral vascular disease10.3SERPINE1, VWF
35ischemia10.3
36blood platelet disease10.3GP1BA, VWF
37retinal vein occlusion10.3SERPINC1, F5
38central retinal vein occlusion10.3PLAT, F5
39sagittal sinus thrombosis10.3SERPINC1, F5
40thrombophilia due to antithrombin iii deficiency10.3F5, SERPINC1
41patent foramen ovale10.3F5
42meningococcemia10.3F5, SERPINC1
43thrombotic thrombocytopenic purpura, acquired10.3F3, VWF, SERPINE1
44post-thrombotic syndrome10.3SERPINC1, F5
45factor xi deficiency, autosomal recessive10.3F5, F3
46legg-calve-perthes disease10.3F5, SERPINC1
47factor viii deficiency10.3F3, F5
48hypoprothrombinemia10.3SERPINC1, F5
49budd-chiari syndrome10.3F5, SERPINC1
50von willebrand's disease10.3VWF, GP1BA, F3

Graphical network of the top 20 diseases related to Coronary Thrombosis:



Diseases related to coronary thrombosis

Symptoms for Coronary Thrombosis

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Drugs & Therapeutics for Coronary Thrombosis

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Drug clinical trials:

Search ClinicalTrials for Coronary Thrombosis

Search NIH Clinical Center for Coronary Thrombosis

Inferred drug relations via UMLS61/NDF-RT40:

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Genetic Tests for Coronary Thrombosis

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Anatomical Context for Coronary Thrombosis

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MalaCards organs/tissues related to Coronary Thrombosis:

31
Heart, Lung, Testes, Brain, Adrenal gland

Animal Models for Coronary Thrombosis or affiliated genes

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Publications for Coronary Thrombosis

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Articles related to Coronary Thrombosis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Multiple and Contemporary Coronary Thrombosis inspite of Low Platelet Function Response. (25302230)
2014
2
Acute coronary thrombosis and multiple coronary aneurysms in a 22-year-old man with the human immunodeficiency virus. (24808786)
2014
3
Antithrombotic effect of Z4A5 on coronary thrombosis in a canine model of acute unstable angina. (23083032)
2013
4
Detection of coronary thrombosis after multi-phase postmortem CT-angiography. (22981180)
2013
5
Simultaneous double coronary thrombosis in a 47-year-old male patient with acute myocardial infarction. (24175009)
2013
6
Right coronary thrombosis in patient supported by Jarvik 2000 left ventricular assist device. (21071239)
2011
7
Acute coronary thrombosis in a patient with diabetes and severe hyperglycemia. (19536400)
2009
8
Incidence of asymptomatic coronary thrombosis and plaque disruption: comparison of non-cardiac and cardiac deaths among autopsy cases. (19000633)
2009
9
Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. (15306180)
2004
10
Coronary thrombosis associated with inherited protein S deficiency: a case report. (9013223)
1997
11
Platelet glycoprotein IIIa polymorphism and coronary thrombosis. (9652554)
1997
12
Human platelet Ca2+ mobilization, glycoprotein IIb/IIIa activation, and experimental coronary thrombosis in vivo in dogs are all inhibited by the inotropic agent amrinone. (9315560)
1997
13
Absence of correlation between coronary thrombosis and postatherectomy restenosis. (9193022)
1997
14
Coronary thrombosis. (8918520)
1996
15
Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. (8641024)
1996
16
'STAR' war against coronary thrombosis. (8714497)
1995
17
Comparison of hirudin and heparin as adjuncts to streptokinase thrombolysis in a canine model of coronary thrombosis. (8477521)
1993
18
An autopsy case of Kawasaki disease with reference to occurrence of acute coronary thrombosis in the convalescent stage. (1449055)
1992
19
Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis. (1689620)
1990
20
Triggers of transient myocardial ischemia: circadian variation and relation to plaque rupture and coronary thrombosis in stable coronary artery disease. (2239711)
1990
21
Therapeutic trials in coronary thrombosis should measure left ventricular function as primary end-point of treatment. (2891942)
1988
22
Effects of 3-methoxycyproheptadine in a canine model of coronary thrombosis. (3183974)
1988
23
Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty. (2954724)
1987
24
Asynchronous left ventricular wall motion early after coronary thrombosis. (3947480)
1986
25
Aspirin for the prevention of coronary thrombosis: current facts and perspectives. (3525167)
1986
26
Exercise-induced myocardial infarction due to coronary thrombosis. (3976482)
1985
27
Prevention of coronary thrombosis with subthrombolytic doses of tissue-type plasminogen activator. (3933849)
1985
28
A review of research into the experience of patients suffering from coronary thrombosis. (255457)
1979
29
Home or hospital care for coronary thrombosis? (667559)
1978
30
The relationship between coronary artery lesions and myocardial infarcts: ulceration of atherosclerotic plaques precipitating coronary thrombosis. (842443)
1977
31
Effect of experimental coronary thrombosis upon platelet kinetics. (4773372)
1973
32
Fibrinolytic activity in coronary artery disease and myocardial infarction, and the role of fibrinolytic therapy in coronary thrombosis. (5648576)
1968
33
The consequences of coronary thrombosis. (6079335)
1967
34
Coronary thrombosis and myocardial infarction. (4162544)
1966
35
LOW INCIDENCE OF CORONARY THROMBOSIS IN MYOCARDIAL INFARCTION. A RESTUDY BY SERIAL BLOCK TECHNIQUE. (14184673)
1964
36
CORONARY THROMBOSIS IN MYOCARDIAL INFARCTION. (14246597)
1964
37
EMOTIONAL REACTIONS TO INITIAL ATTACKS OF CORONARY THROMBOSIS. (14132354)
1964
38
Physical effort and emotion in acute coronary thrombosis. (13959728)
1963
39
Coronary thrombosis. (14025542)
1962
40
Experimental myocardial infarction. Induction of coronary thrombosis in the intact closed-chest dog. (14496296)
1961
41
Successful cardiac massage for cardiac arrest following coronary thrombosis. (13842766)
1960
42
Note on a case of coronary thrombosis at an unusually early age. (14413560)
1960
43
The failure of anticoagulant therapy to prevent coronary thrombosis after long-term use and in impending myocardial infarction (with case reports). (13811495)
1959
44
Further observations concerning the prognosis of myocardial infarction due to coronary thrombosis. (13488214)
1958
45
Coronary thrombosis in general practice. (13465575)
1957
46
Coronary thrombosis. (13269933)
1955
47
Coronary thrombosis in a five-month-old infant. (14354590)
1955
48
Coronary thrombosis; a comparative study of 270 cases. (13199832)
1954
49
Experiences with aspirin (Acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis. (13013156)
1953
50
Long term dicumarol therapy in thromboembolic conditions, especially coronary thrombosis. (13091736)
1953

Variations for Coronary Thrombosis

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Expression for genes affiliated with Coronary Thrombosis

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Search GEO for disease gene expression data for Coronary Thrombosis.

Pathways for genes affiliated with Coronary Thrombosis

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Pathways related to Coronary Thrombosis according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLAT, SERPINE1
29.8GP1BA, VWF
3
Show member pathways
Serotonin Transporter Activity36
9.6SLC6A4, ITGB3
4
Show member pathways
Metalloproteases in connective tissue degradation
9.5FGA, PLAT, SERPINE1
59.5VWF, GP6, GP1BA
6
Show member pathways
9.2GP1BA, VWF, ITGB3, FGA
7
Show member pathways
thioredoxin pathway36
9.1PTGS2, SERPINE1, PLAT
8
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
9.1F3, SERPINE1, PTGS2
9
Show member pathways
9.0FGA, F5, F3, SERPINC1
108.8FGA, ITGB3, P2RY12, GP6, VWF
11
Show member pathways
8.7F5, ITGB3, FGA, VWF, SERPINE1
12
Show member pathways
8.7FGA, VWF, SERPINE1, P2RY12, ITGB3, PLAT
13
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.4VWF, ITGB3, GP6, GP1BA, PTGS2
14
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.2PLAT, F5, F3, FGA, VWF, SERPINE1
15
Show member pathways
7.5SERPINC1, FGA, F5, PLAT, F3, VWF
16
Show member pathways
6.9F5, FGA, PLAT, ITGB3, VWF, GP6

Compounds for genes affiliated with Coronary Thrombosis

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Compounds related to Coronary Thrombosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1reviparin449.9SERPINC1, PLAT, F3
2integrilin449.9PLAT, SERPINC1, VWF
3epsilon aminocaproic acid449.7PLAT, F3, SERPINC1, SERPINE1
4efegatran449.6SERPINC1, F3, PLAT
5fucoidan449.6SERPINC1, PLAT, SERPINE1, F3
6spectrozyme449.6F5, F3, PLAT, SERPINC1
7desirudin449.5PLAT, F3, FGA
8fondaparinux449.5F3, SERPINC1, F5, PLAT
9tranexamic acid44 1110.5VWF, PLAT, SERPINE1, SERPINC1, F3
10inogatran449.5SERPINC1, F3, F5
11protamine sulfate449.5F5, PLAT, F3, SERPINC1
12batroxobin449.3SERPINE1, F5, FGA, PLAT
13tirofiban44 1110.3SERPINC1, P2RY12, ITGB3, PLAT, F3, VWF
14levonorgestrel44 60 28 1112.3PLAT, SERPINC1, F3, F5
15hirugen449.3F5, FGA, SERPINC1
16clopidogrel44 50 24 1112.3F3, ITGB3, PLAT, VWF, P2RY12, SERPINC1
17dermatan sulfate449.2F5, PLAT, F3, VWF, SERPINC1
18convulxin449.2P2RY12, GP1BA, GP6, F5
19bivalirudin44 1110.2F3, F5, FGA, SERPINC1, PLAT
20argatroban44 1110.2PLAT, FGA, F5, SERPINC1, F3
21ancrod449.2SERPINE1, SERPINC1, PLAT, F5, FGA
22ppack449.1FGA, PLAT, P2RY12, F3, SERPINC1, VWF
23ticlopidine44 1110.1PLAT, VWF, FGA, SERPINC1, F3, P2RY12
24abciximab44 1110.0PLAT, VWF, GP1BA, SERPINC1, F3, P2RY12
25homocysteine44 2410.0PLAT, F5, SERPINC1, VWF, SERPINE1, F3
26protamine448.9SERPINE1, SERPINC1, F3, FGA, F5, PLAT
27warfarin44 50 24 1111.9SERPINC1, F5, F3, PLAT, FGA, VWF
28raloxifene44 50 28 1111.8SERPINE1, SERPINC1, F5, SLC6A4, VWF
29pge1448.8P2RY12, FGA, PLAT, SERPINE1, VWF, F5
30phosphatidylserine44 28 1110.7ITGB3, GP6, F5, VWF, F3, GP1BA
31kininogen448.7GP1BA, F5, SERPINE1, SERPINC1, F3, VWF
32simvastatin44 50 60 28 24 1113.6VWF, SERPINE1, F3, PLAT, F5, SLC6A4
33ristocetin448.4ITGB3, PLAT, F5, F3, SERPINC1, VWF
34thromboxane44 249.4P2RY12, VWF, FGA, PLAT, PTGS2, GP6
35thromboxane a244 249.4PTGS2, P2RY12, PLAT, VWF, GP6, FGA
36aprotinin44 119.3F3, FGA, F5, PLAT, SERPINC1, SERPINE1
37hirudin448.3FGA, F5, PLAT, F3, SERPINC1, SERPINE1
38aspartate448.2ITGB3, PLAT, SERPINE1, F5, SLC6A4, VWF
39creatinine447.9FGA, F5, SERPINC1, PLAT, GP6, SERPINE1
40desmopressin44 60 28 1110.9F5, PLAT, F3, SERPINC1, SERPINE1, PTGS2
41alanine447.8SLC6A4, VWF, ITGB3, SERPINC1, F3, GP1BA
42epinephrine44 24 119.7F3, P2RY12, F5, SLC6A4, FGA, GP1BA
43vegf447.6F5, ITGB3, VWF, F3, SERPINC1, SERPINE1
44adp44 28 249.5GP1BA, SERPINC1, GP6, VWF, F3, P2RY12
45prostacyclin447.5FGA, F5, PLAT, F3, SERPINC1, SERPINE1
46fibrinogen447.4F3, FGA, VWF, ITGB3, P2RY12, PLAT
47cysteine447.2F3, PLAT, F5, GP6, SERPINF1, SLC6A4
48heparin44 28 24 1110.0F3, P2RY12, PLAT, F5, FGA, POU2F3
49serine446.6SLC6A4, FGA, F5, ITGB3, F3, SERPINC1
50aspirin44 50 28 249.5SERPINE1, PTGS2, GP1BA, GP6, VWF, SERPINC1

GO Terms for genes affiliated with Coronary Thrombosis

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Cellular components related to Coronary Thrombosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:00310919.5FGA, VWF
2external side of plasma membraneGO:00098979.5FGA, P2RY12, VWF
3platelet alpha granule lumenGO:00310939.1VWF, SERPINE1, F5, FGA
4extracellular matrixGO:00310129.1PLAT, F3, SERPINE1, SERPINF1, VWF
5extracellular spaceGO:00056158.1SERPINF1, SERPINE1, SERPINC1, F3, PLAT, F5
6extracellular regionGO:00055767.9VWF, SERPINF1, SERPINE1, SERPINC1, PLAT, F5
7plasma membraneGO:00058866.8GP6, GP1BA, SERPINE1, SERPINC1, F3, P2RY12

Biological processes related to Coronary Thrombosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:001490910.2PLAT, ITGB3
2platelet aggregationGO:00705279.9ITGB3, P2RY12
3hemostasisGO:00075999.9P2RY12, VWF
4fibrinolysisGO:00427309.8GP1BA, SERPINE1, PLAT
5negative regulation of endopeptidase activityGO:00109519.6SERPINF1, SERPINE1, SERPINC1
6blood coagulation, intrinsic pathwayGO:00075979.5GP1BA, VWF
7extracellular matrix organizationGO:00301989.4FGA, ITGB3, SERPINE1, VWF
8negative regulation of synaptic transmission, dopaminergicGO:00322279.2SLC6A4, PTGS2
9response to glucocorticoidGO:00513849.1PTGS2, SERPINF1, PLAT
10cell adhesionGO:00071559.0VWF, GP1BA, ITGB3, F5
11platelet degranulationGO:00025769.0VWF, SERPINE1, ITGB3, F5, FGA
12platelet activationGO:00301687.9VWF, GP6, GP1BA, SERPINE1, P2RY12, ITGB3
13blood coagulationGO:00075967.2FGA, VWF, GP6, GP1BA, SERPINE1, SERPINC1

Molecular functions related to Coronary Thrombosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00048679.5SERPINC1, SERPINE1, SERPINF1
2protease bindingGO:00020209.3F3, SERPINC1, SERPINE1, VWF
3protein bindingGO:00055155.8SERPINC1, SERPINE1, GP1BA, GP6, VWF, POU2F3

Sources for Coronary Thrombosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet