MCID: CRN017
MIFTS: 59

Coronary Thrombosis malady

Cardiovascular diseases, Blood diseases categories
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Summaries for Coronary Thrombosis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Coronary thrombosis is the formation of a blood clot inside a blood vessel of the heart. This blood clot... more...

MalaCards: Coronary Thrombosis, also known as coronary artery thrombosis, is related to myocardial infarction and acute myocardial infarction. An important gene associated with Coronary Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and GP1b-IX-V activation signalling. The drugs heparin and heparin sodium and the compounds reviparin and integrilin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Coronary Thrombosis

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


Aliases & Descriptions:

coronary thrombosis 8 45 62
coronary artery thrombosis 8


External Ids:

Disease Ontology8 DOID:11847
MeSH35 D003328

Related Diseases for Coronary Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Coronary Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction30.9PLAT, F5, SLC6A4, FGA, ITGB3, P2RY12
2acute myocardial infarction30.9VWF, SERPINE1, SERPINC1, F3, PLAT, SLC6A4
3thrombocytosis30.6VWF, GP1BA, SERPINC1, F3, FGA
4coronary artery disease30.6GP6, SERPINE1, ITGB3, PLAT, FGA
5purpura30.6SERPINC1
6atherosclerosis30.4SERPINE1, SERPINF1, PTGS2, VWF, SERPINC1, F3
7antiphospholipid syndrome30.4VWF, SERPINC1, F3, PLAT, F5
8lupus erythematosus30.3F5, F3, SERPINC1
9pulmonary embolism30.2SERPINC1, F3, PLAT, F5, FGA
10thromboembolism30.2VWF, GP6, SERPINE1, SERPINC1, F3, PLAT
11antithrombin iii deficiency30.1SERPINC1, F5
12thrombocytopenia30.1FGA, F5, ITGB3, F3, VWF, GP6
13protein c deficiency30.1SERPINE1, SERPINC1, F5
14vascular disease30.1VWF, PTGS2, SERPINC1, F3
15hyperglycemia30.0FGA, SERPINE1, SERPINF1
16protein s deficiency30.0F5, SERPINC1
17septic shock30.0SERPINE1, SERPINC1, F3, F5, FGA
18hypertension29.9SERPINE1, PLAT, F5, SLC6A4
19disseminated intravascular coagulation29.9SERPINE1, SERPINC1, F3, PLAT, F5, FGA
20thrombophilia29.9SERPINC1, F3, PLAT, F5, FGA, SERPINE1
21artery disease10.4
22ischemia10.3
23heparin-induced thrombocytopenia10.3
24kawasaki disease10.2
25tuberculosis10.2
26essential thrombocythemia10.2
27systemic lupus erythematosus10.2
28catastrophic antiphospholipid syndrome10.2
29coronary artery aneurysm10.2
30central retinal artery occlusion10.1PLAT
31eclampsia10.1SERPINC1
32angiodysplasia10.1VWF
33sneddon syndrome10.1SERPINC1
34intermittent claudication10.1VWF
35endophthalmitis10.1PLAT
36afibrinogenemia10.1FGA
37hemophilia b10.1F3
38carotid artery thrombosis10.1SERPINE1, F3
39intermediate coronary syndrome10.1SERPINC1, PLAT
40macular holes10.1SERPINF1
41hemarthrosis10.1VWF, F3
42pseudo-von willebrand disease10.1VWF, GP1BA
43branch retinal artery occlusion10.1F5
44hemorrhagic disease10.1SERPINE1, PLAT
45hemorrhage, intracerebral10.1F3, PLAT
46peripheral vascular disease10.1VWF, SERPINE1
47blood platelet disease10.1VWF, GP1BA
48retinal vein occlusion10.1SERPINC1, F5
49central retinal vein occlusion10.1PLAT, F5
50purpura fulminans10.1SERPINC1, F5

Graphical network of the top 20 diseases related to Coronary Thrombosis:



Diseases related to coronary thrombosis

Symptoms for Coronary Thrombosis

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Drugs & Therapeutics for Coronary Thrombosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Coronary Thrombosis

Search NIH Clinical Center for Coronary Thrombosis

Inferred drug relations via UMLS62/NDF-RT41:

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Genetic Tests for Coronary Thrombosis

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Anatomical Context for Coronary Thrombosis

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33MalaCards
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MalaCards organs/tissues related to Coronary Thrombosis:

33
Heart, Lung, Testes, Brain, Adrenal gland

Animal Models for Coronary Thrombosis or affiliated genes

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37MGI
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Publications for Coronary Thrombosis

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52PubMed
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Articles related to Coronary Thrombosis:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Antithrombotic effect of Z4A5 on coronary thrombosis in a canine model of acute unstable angina. (23083032)
2013
2
Detection of coronary thrombosis after multi-phase postmortem CT-angiography. (22981180)
2013
3
Simultaneous double coronary thrombosis in a 47-year-old male patient with acute myocardial infarction. (24175009)
2013
4
Right coronary thrombosis in patient supported by Jarvik 2000 left ventricular assist device. (21071239)
2011
5
Acute coronary thrombosis in a patient with diabetes and severe hyperglycemia. (19536400)
2009
6
Clinically relevant concentrations of dopamine do not amplify agonist-induced human platelet Ca2+ mobilization or GP IIb IIIa activation and do not accelerate acute coronary thrombosis in dogs. (19247190)
2009
7
The success of clopidogrel treatment for recurrent coronary thrombosis in a patient with aortic and mitral valve replacement. (18160612)
2008
8
Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. (15306180)
2004
9
Coronary thrombosis associated with inherited protein S deficiency: a case report. (9013223)
1997
10
Platelet glycoprotein IIIa polymorphism and coronary thrombosis. (9652554)
1997
11
Human platelet Ca2+ mobilization, glycoprotein IIb/IIIa activation, and experimental coronary thrombosis in vivo in dogs are all inhibited by the inotropic agent amrinone. (9315560)
1997
12
Absence of correlation between coronary thrombosis and postatherectomy restenosis. (9193022)
1997
13
Coronary thrombosis. (8918520)
1996
14
Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. (8641024)
1996
15
'STAR' war against coronary thrombosis. (8714497)
1995
16
Comparison of hirudin and heparin as adjuncts to streptokinase thrombolysis in a canine model of coronary thrombosis. (8477521)
1993
17
An autopsy case of Kawasaki disease with reference to occurrence of acute coronary thrombosis in the convalescent stage. (1449055)
1992
18
Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis. (1689620)
1990
19
Triggers of transient myocardial ischemia: circadian variation and relation to plaque rupture and coronary thrombosis in stable coronary artery disease. (2239711)
1990
20
Therapeutic trials in coronary thrombosis should measure left ventricular function as primary end-point of treatment. (2891942)
1988
21
Effects of 3-methoxycyproheptadine in a canine model of coronary thrombosis. (3183974)
1988
22
Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty. (2954724)
1987
23
Asynchronous left ventricular wall motion early after coronary thrombosis. (3947480)
1986
24
Aspirin for the prevention of coronary thrombosis: current facts and perspectives. (3525167)
1986
25
Exercise-induced myocardial infarction due to coronary thrombosis. (3976482)
1985
26
Prevention of coronary thrombosis with subthrombolytic doses of tissue-type plasminogen activator. (3933849)
1985
27
A review of research into the experience of patients suffering from coronary thrombosis. (255457)
1979
28
Home or hospital care for coronary thrombosis? (667559)
1978
29
The relationship between coronary artery lesions and myocardial infarcts: ulceration of atherosclerotic plaques precipitating coronary thrombosis. (842443)
1977
30
Effect of experimental coronary thrombosis upon platelet kinetics. (4773372)
1973
31
Fibrinolytic activity in coronary artery disease and myocardial infarction, and the role of fibrinolytic therapy in coronary thrombosis. (5648576)
1968
32
The consequences of coronary thrombosis. (6079335)
1967
33
Coronary thrombosis and myocardial infarction. (4162544)
1966
34
LOW INCIDENCE OF CORONARY THROMBOSIS IN MYOCARDIAL INFARCTION. A RESTUDY BY SERIAL BLOCK TECHNIQUE. (14184673)
1964
35
CORONARY THROMBOSIS IN MYOCARDIAL INFARCTION. (14246597)
1964
36
EMOTIONAL REACTIONS TO INITIAL ATTACKS OF CORONARY THROMBOSIS. (14132354)
1964
37
Physical effort and emotion in acute coronary thrombosis. (13959728)
1963
38
Coronary thrombosis. (14025542)
1962
39
Experimental myocardial infarction. Induction of coronary thrombosis in the intact closed-chest dog. (14496296)
1961
40
Successful cardiac massage for cardiac arrest following coronary thrombosis. (13842766)
1960
41
Note on a case of coronary thrombosis at an unusually early age. (14413560)
1960
42
The failure of anticoagulant therapy to prevent coronary thrombosis after long-term use and in impending myocardial infarction (with case reports). (13811495)
1959
43
Further observations concerning the prognosis of myocardial infarction due to coronary thrombosis. (13488214)
1958
44
Stress, coronary thrombosis and myocardial infarction. (13502572)
1958
45
Coronary thrombosis in general practice. (13465575)
1957
46
Coronary thrombosis. (13269933)
1955
47
Coronary thrombosis in a five-month-old infant. (14354590)
1955
48
Coronary thrombosis; a comparative study of 270 cases. (13199832)
1954
49
Experiences with aspirin (Acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis. (13013156)
1953
50
Long term dicumarol therapy in thromboembolic conditions, especially coronary thrombosis. (13091736)
1953

Variations for Coronary Thrombosis

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Expression for genes affiliated with Coronary Thrombosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coronary Thrombosis

Search GEO for disease gene expression data for Coronary Thrombosis.

Pathways for genes affiliated with Coronary Thrombosis

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 54R&D Systems, 53QIAGEN, 51PharmGKB, 30KEGG
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Pathways related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLAT, SERPINE1
29.8GP1BA, VWF
3
Show member pathways
Serotonin Transporter Activity38
9.6SLC6A4, ITGB3
4
Show member pathways
9.5SERPINE1, PLAT, FGA
59.5GP1BA, GP6, VWF
6
Show member pathways
9.2VWF, GP1BA, ITGB3, FGA
7
Show member pathways
thioredoxin pathway38
9.1PLAT, SERPINE1, PTGS2
8
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1F3, SERPINE1, PTGS2
9
Show member pathways
9.0SERPINC1, F3, F5, FGA
108.8VWF, GP6, P2RY12, ITGB3, FGA
11
Show member pathways
8.7FGA, F5, ITGB3, SERPINE1, VWF
12
Show member pathways
8.7VWF, SERPINE1, P2RY12, ITGB3, PLAT, FGA
13
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.4VWF, GP6, GP1BA, PTGS2, ITGB3
14
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.2VWF, SERPINE1, SERPINC1, F3, PLAT, F5
15
Show member pathways
7.5F5, PLAT, F3, SERPINC1, SERPINE1, GP1BA
16
Show member pathways
6.9FGA, VWF, GP6, F5, PLAT, ITGB3

Compounds for genes affiliated with Coronary Thrombosis

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 24HMDB
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Compounds related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1reviparin459.9SERPINC1, PLAT, F3
2integrilin459.9PLAT, SERPINC1, VWF
3efegatran459.7PLAT, F3, SERPINC1
4epsilon aminocaproic acid459.7PLAT, F3, SERPINC1, SERPINE1
5desirudin459.6PLAT, F3, FGA
6fucoidan459.6F3, SERPINC1, SERPINE1, PLAT
7spectrozyme459.6F3, PLAT, F5, SERPINC1
8fondaparinux459.5F5, SERPINC1, PLAT, F3
9tranexamic acid45 1110.5F3, SERPINC1, SERPINE1, VWF, PLAT
10protamine sulfate459.5SERPINC1, F5, PLAT, F3
11ecarin459.5F5, F3, SERPINC1
12inogatran459.4SERPINC1, F3, F5
13batroxobin459.3PLAT, F5, FGA, SERPINE1
14levonorgestrel45 61 29 1112.3F3, SERPINC1, PLAT, F5
15tirofiban45 1110.3VWF, SERPINC1, F3, P2RY12, PLAT, ITGB3
16clopidogrel45 51 24 1112.3VWF, P2RY12, ITGB3, PLAT, F3, SERPINC1
17dermatan sulfate459.2PLAT, VWF, F5, SERPINC1, F3
18convulxin459.2GP1BA, F5, GP6, P2RY12
19bivalirudin45 1110.2F5, FGA, PLAT, F3, SERPINC1
20argatroban45 1110.2FGA, F5, PLAT, F3, SERPINC1
21ancrod459.2SERPINC1, SERPINE1, PLAT, F5, FGA
22ppack459.1FGA, PLAT, P2RY12, F3, SERPINC1, VWF
23ticlopidine45 1110.1PLAT, FGA, P2RY12, F3, SERPINC1, VWF
24abciximab45 1110.0PLAT, P2RY12, ITGB3, GP1BA, VWF, SERPINC1
25homocysteine45 2410.0PLAT, VWF, F5, F3, SERPINC1, SERPINE1
26protamine458.9F5, PLAT, F3, SERPINC1, SERPINE1, FGA
27warfarin45 51 24 1111.9F3, F5, PLAT, FGA, VWF, SERPINC1
28raloxifene45 51 29 1111.8SERPINC1, SERPINE1, VWF, F5, SLC6A4
29pge1458.8PLAT, SERPINE1, P2RY12, VWF, FGA, F5
30phosphatidylserine45 29 1110.7VWF, F5, ITGB3, F3, GP1BA, GP6
31kininogen458.7GP1BA, VWF, F5, PLAT, F3, SERPINC1
32simvastatin45 51 61 29 24 1113.6VWF, SERPINE1, F3, PLAT, F5, SLC6A4
33ristocetin458.4ITGB3, PLAT, F5, F3, SERPINC1, VWF
34thromboxane45 249.4FGA, VWF, GP6, PTGS2, P2RY12, PLAT
35thromboxane a245 249.4P2RY12, PTGS2, GP6, PLAT, FGA, VWF
36hirudin458.3FGA, F5, PLAT, F3, SERPINC1, SERPINE1
37aprotinin45 119.3FGA, F5, PLAT, F3, SERPINC1, SERPINE1
38aspartate458.2SLC6A4, VWF, F5, F3, PLAT, SERPINE1
39creatinine457.9VWF, GP6, SERPINE1, SERPINC1, F3, PLAT
40desmopressin45 61 29 1110.9PLAT, F5, F3, SERPINC1, VWF, GP1BA
41alanine457.8F5, GP6, VWF, SLC6A4, GP1BA, ITGB3
42epinephrine45 24 119.7GP1BA, F3, GP6, VWF, P2RY12, FGA
43vegf457.6SERPINE1, F5, PTGS2, ITGB3, SERPINF1, VWF
44adp45 29 249.5VWF, SLC6A4, FGA, PLAT, ITGB3, P2RY12
45prostacyclin457.5FGA, F5, PLAT, F3, SERPINC1, SERPINE1
46fibrinogen457.4FGA, F5, PLAT, ITGB3, P2RY12, F3
47cysteine457.2SLC6A4, PLAT, ITGB3, F3, SERPINF1, GP6
48heparin45 29 24 1110.0FGA, SERPINC1, F5, PLAT, P2RY12, F3
49serine456.6GP6, SERPINC1, SERPINE1, SERPINF1, F3, ITGB3
50aspirin45 51 29 249.5SERPINE1, PTGS2, GP1BA, GP6, VWF, SERPINC1

GO Terms for genes affiliated with Coronary Thrombosis

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16Gene Ontology
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Cellular components related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:0310919.5FGA, VWF
2external side of plasma membraneGO:0098979.5FGA, P2RY12, VWF
3platelet alpha granule lumenGO:0310939.1VWF, SERPINE1, F5, FGA
4extracellular matrixGO:0310129.1PLAT, F3, SERPINE1, SERPINF1, VWF
5extracellular spaceGO:0056158.1SERPINF1, SERPINE1, SERPINC1, F3, PLAT, F5
6extracellular regionGO:0055767.9VWF, SERPINF1, SERPINE1, SERPINC1, PLAT, F5
7plasma membraneGO:0058866.8GP6, GP1BA, SERPINE1, SERPINC1, F3, P2RY12

Biological processes related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:01490910.2PLAT, ITGB3
2platelet aggregationGO:0705279.9ITGB3, P2RY12
3hemostasisGO:0075999.9P2RY12, VWF
4fibrinolysisGO:0427309.8GP1BA, SERPINE1, PLAT
5negative regulation of endopeptidase activityGO:0109519.6SERPINF1, SERPINE1, SERPINC1
6blood coagulation, intrinsic pathwayGO:0075979.5GP1BA, VWF
7extracellular matrix organizationGO:0301989.4FGA, ITGB3, SERPINE1, VWF
8negative regulation of synaptic transmission, dopaminergicGO:0322279.2SLC6A4, PTGS2
9response to glucocorticoidGO:0513849.1PTGS2, SERPINF1, PLAT
10cell adhesionGO:0071559.0VWF, GP1BA, ITGB3, F5
11platelet degranulationGO:0025769.0VWF, SERPINE1, ITGB3, F5, FGA
12platelet activationGO:0301687.9VWF, GP6, GP1BA, SERPINE1, P2RY12, ITGB3
13blood coagulationGO:0075967.2FGA, VWF, GP6, GP1BA, SERPINE1, SERPINC1

Molecular functions related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.5SERPINC1, SERPINE1, SERPINF1
2protease bindingGO:0020209.3F3, SERPINC1, SERPINE1, VWF
3protein bindingGO:0055155.8SERPINC1, SERPINE1, GP1BA, GP6, VWF, POU2F3

Products for genes affiliated with Coronary Thrombosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coronary Thrombosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet