MCID: CRN017
MIFTS: 57

Coronary Thrombosis malady

Blood diseases category

Summaries for Coronary Thrombosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Coronary thrombosis is the formation of a blood clot inside a blood vessel of the heart. This blood clot... more...

MalaCards: Coronary Thrombosis, also known as coronary artery thrombosis, is related to myocardial infarction and acute myocardial infarction. An important gene associated with Coronary Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and GP1b-IX-V activation signalling. The drugs heparin and heparin sodium and the compounds integrilin and reviparin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related mouse phenotypes are vision/eye and integument.

Aliases & Classifications for Coronary Thrombosis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

coronary thrombosis 8 44 60
coronary artery thrombosis 8


External Ids:

Disease Ontology8 DOID:11847
MeSH34 D003328

Related Diseases for Coronary Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Coronary Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.3F3, VWF, P2RY12, GP6, GP1BA, PLAT
2acute myocardial infarction31.0FGA, F3, VWF, PLAT, SLC6A4, SERPINE1
3atherosclerosis30.5ITGB3, FGA, F3, VWF, P2RY12, PLAT
4thrombocytosis30.5FGA, F3, VWF, GP1BA, SERPINC1
5coronary artery disease30.5SERPINE1, PLAT, GP1BA, GP6, P2RY12, VWF
6ischemia30.4FGA, PLAT
7purpura30.3SERPINC1
8antiphospholipid syndrome30.3F3, F5, VWF, PLAT, SERPINC1
9thrombocytopenia30.2ITGB3, F5, POU2F3, FGA, F3, VWF
10lupus erythematosus30.1SERPINC1, F3, F5
11pulmonary embolism30.1F5, FGA, F3, PLAT, SERPINC1
12diabetes mellitus30.1FGA, VWF, GP1BA, PLAT, SERPINE1, SERPINC1
13antithrombin iii deficiency29.9SERPINC1, F5
14hyperglycemia29.9FGA, SERPINE1, SERPINF1
15protein c deficiency29.9F5, SERPINE1, SERPINC1
16hypertension29.9F5, PLAT, SLC6A4, SERPINE1
17protein s deficiency29.9F5, FGA, F3, SERPINE1, SERPINC1
18disseminated intravascular coagulation29.9SERPINC1, SERPINE1, F5, FGA, F3, PLAT
19thrombophilia29.9F5, FGA, F3, VWF, PLAT, SERPINE1
20vascular disease29.9FGA, F3, VWF, P2RY12, GP1BA, PLAT
21coronary restenosis10.2
22kawasaki disease10.1
23tuberculosis10.1
24systemic lupus erythematosus10.1
25eclampsia10.0SERPINC1
26polycythemia vera10.0ITGB3
27polycythemia10.0ITGB3
28central retinal artery occlusion10.0PLAT
29intermittent claudication10.0VWF
30polycystic ovary syndrome10.0SERPINE1
31age related macular degeneration10.0PLAT
32obesity10.0SERPINE1
33hemolytic-uremic syndrome10.0VWF
34angiodysplasia10.0VWF
35blindness10.0SERPINF1
36uremia10.0VWF
37arteriosclerosis10.0SERPINE1
38asthma10.0ITGB3
39osteosarcoma10.0SERPINF1
40sneddon syndrome10.0SERPINC1
41hypothyroidism10.0VWF
42proteinuria10.0FGA
43proliferative diabetic retinopathy10.0SERPINF1
44pancreatic cancer10.0PTGS2
45afibrinogenemia10.0FGA
46pneumonia10.0FGA
47oral cancer10.0PTGS2
48arthritis10.0PTGS2
49dilated cardiomyopathy10.0FGA
50cataract10.0SERPINF1

Graphical network of the top 20 diseases related to Coronary Thrombosis:



Diseases related to coronary thrombosis

Clinical Features for Coronary Thrombosis

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Drugs & Therapeutics for Coronary Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Coronary Thrombosis

Drug clinical trials:

Search ClinicalTrials for Coronary Thrombosis

Search NIH Clinical Center for Coronary Thrombosis

Search CenterWatch for Coronary Thrombosis

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Coronary Thrombosis

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Anatomical Context for Coronary Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Coronary Thrombosis:

32
Heart, Lung, Testes, Brain, Liver, Adrenal gland, Endothelial

Animal Models for Coronary Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Coronary Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.7ITGB3, PLAT, SERPINF1
2MP:00107718.8FGA, SLC6A4, PTGS2
3MP:00053858.0ITGB3, FGA, F3, SLC6A4, PTGS2, SERPINF1
4MP:00053817.8ITGB3, FGA, VWF, PLAT, PTGS2, SERPINF1
5MP:00053707.7ITGB3, F5, FGA, PTGS2, SERPINE1, SERPINC1
6MP:00053877.6FGA, F3, VWF, PLAT, PTGS2, SERPINE1
7MP:00053976.7ITGB3, FGA, F3, VWF, P2RY12, GP6
8MP:00036316.7F5, FGA, F3, VWF, PLAT, SLC6A4
9MP:00107686.1ITGB3, F5, POU2F3, FGA, F3, VWF
10MP:00053765.6SERPINC1, ITGB3, F5, FGA, F3, VWF

Publications for Coronary Thrombosis

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50PubMed
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Articles related to Coronary Thrombosis:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
SYNTAX Score and the risk of stent thrombosis after percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes: An ACUITY trial substudy. (24408084)
2014
2
Contemporary analysis of incidence and outcomes of stent thrombosis presenting as ST elevation myocardial infarction in a primary percutaneous coronary intervention cohort. (24012030)
2013
3
Coronary microvasculopathy and intracardiac thrombosis in antiphospholipid syndrome. (22958890)
2012
4
Very late coronary aneurysm formation with subsequent stent thrombosis secondary to drug-eluting stent. (22088549)
2011
5
Spontaneous aortic thrombosis causing left main coronary occlusion in a man with secondary polycythemia. (21851910)
2011
6
Coronary artery bypass graft surgery after acute myocardial infarction caused by thrombosis of coronary aneurysm. (22358286)
2011
7
Coronary artery aneurysm and thrombosis following chronic ephedra use. (18718687)
2010
8
Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. (20083681)
2010
9
Markers of inflammation, thrombosis and endothelial activation correlate with carotid IMT regression in stable coronary disease after atorvastatin treatment. (19171469)
2009
10
Use of 64-multislice computed tomography for detection of coronary thrombosis. (19001941)
2008
11
Coronary thrombosis in a patient with leukemic thrombocytosis: which was the best treatment? (18319708)
2008
12
Sildenafil-associated coronary thrombosis in a patient with angiographically normal coronary arteries: a case report with review of literature. (16858176)
2006
13
Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease. (15897349)
2005
14
Cocaine-induced coronary thrombosis and acute myocardial infarction. (15301905)
2004
15
In vivo magnetic resonance imaging of coronary thrombosis using a fibrin-binding molecular magnetic resonance contrast agent. (15238457)
2004
16
Platelet membrane glycoprotein Ibalpha gene -5T/C Kozak sequence polymorphism as an independent risk factor for the occurrence of coronary thrombosis. (11751671)
2002
17
n-3 polyunsaturated fatty acids and coronary thrombosis. (11837997)
2001
18
Timing of and risk factors for myocardial ischemic events after percutaneous coronary intervention (IMPACT-II). Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis. (10728945)
2000
19
Lipoprotein(a) and coronary thrombosis and restenosis after stent placement. (10091828)
1999
20
Impact of eptifibatide on early ischemic events in acute ischemic coronary syndromes: a review of the IMPACT II trial. Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis. (9291242)
1997
21
The role of thrombin in coronary artery thrombosis. (8889355)
1996
22
Coronary thrombosis. (8918520)
1996
23
Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. (8641024)
1996
24
Frequency and characteristics of coronary thrombosis in the epicardial coronary arteries after cardiac transplantation. (8857485)
1996
25
Comparison of desulfatohirudin (REVASC) and heparin as adjuncts to thrombolytic therapy with reteplase in a canine model of coronary thrombosis. (8735626)
1996
26
'STAR' war against coronary thrombosis. (8714497)
1995
27
Comparison of hirudin and heparin as adjuncts to streptokinase thrombolysis in a canine model of coronary thrombosis. (8477521)
1993
28
Thrombosis of a flexible coil coronary stent: frequency, predictors and clinical outcome. (8436743)
1993
29
Beneficial effects of combined thromboxane synthase inhibition/receptor blockade with CGS 22652 in a canine model of coronary thrombosis. (8319746)
1993
30
Evaluation of thrombolytic and systemic effects of the novel recombinant plasminogen activator BM 06.022 compared with alteplase, anistreplase, streptokinase and urokinase in a canine model of coronary artery thrombosis. (1732372)
1992
31
Coronary thrombosis postpartum in a young woman with Still's disease. (1563136)
1992
32
von Willebrand factor and animal models: contributions to gene therapy, thrombotic thrombocytopenic purpura, and coronary artery thrombosis. (2072761)
1991
33
Leukotriene-receptor antagonist FPL-55712 and t-PA-induced thrombolysis in canine coronary thrombosis. (2160745)
1990
34
Hypothesis: warfarin administered simultaneously with heparin infusion will prevent heparin-discontinuance associated coronary thrombosis. (2191783)
1990
35
Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. (3971539)
1985
36
Influence of prostacyclin on coronary thrombosis and myocardial ischemia in conscious canine experiments. (3913392)
1985
37
Morphology of acute myocardial infarction in relation to coronary thrombosis. (4808760)
1974
38
Nursing care study: coronary thrombosis. (4486695)
1973
39
Sudden death in coronary thrombosis. A study of the accuracy of death certification. (5144382)
1971
40
Thrombolytic therapy in coronary thrombosis. (4891485)
1969
41
Fibrinolytic activity in coronary artery disease and myocardial infarction, and the role of fibrinolytic therapy in coronary thrombosis. (5648576)
1968
42
The dangers of hypoglycaemia in diabetics with coronary thrombosis. (5710921)
1968
43
ORAL CONTRACEPTIVES AND CORONARY THROMBOSIS. (14229715)
1965
44
CORONARY THROMBOSIS: ITS MECHANISM AND POSSIBLE PREVENTION BY LINOLENIC ACID. (14318462)
1965
45
Coronary thrombosis. (13795193)
1960
46
Tuberculosis and coronary thrombosis. (13435680)
1957
47
Coronary thrombosis in general practice. (13359218)
1956
48
Trauma in relation to coronary thrombosis: a clinical study of 42 cases of coronary thrombosis following trauma or unusual effort. (13125216)
1954
49
Does exertion precipitate coronary thrombosis? (13090777)
1953
50
MASSACHUSETTS General Hospital: recent, right coronary thrombosis with old, left coronary thrombosis and myocardial infarction. (13051280)
1953

Genetic Variations for Coronary Thrombosis

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Expression for genes affiliated with Coronary Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coronary Thrombosis

Search GEO for disease gene expression data for Coronary Thrombosis.

Pathways for genes affiliated with Coronary Thrombosis

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB, 29KEGG, 52R&D Systems
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Pathways related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLAT, SERPINE1
29.8VWF, GP1BA
3
Hide members
9.5VWF, FGA, ITGB3
4
Cell adhesion ECM remodeling
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9.5SERPINE1, PLAT, FGA
59.4VWF, GP6, GP1BA
6
Hide members
9.1GP1BA, VWF, FGA, ITGB3
79.1SERPINE1, PTGS2, PLAT
8
Hide members
9.1SERPINE1, PTGS2, F3
9
Hide members
8.9F5, FGA, F3, SERPINC1
108.8ITGB3, FGA, VWF, P2RY12, GP6
11
Hide members
8.6ITGB3, F5, FGA, VWF, SERPINE1
12
Hide members
8.4ITGB3, FGA, VWF, GP6, GP1BA, SERPINE1
13
Hide members
8.3GP1BA, GP6, P2RY12, VWF, F3, FGA
14
Hide members
8.3ITGB3, F5, FGA, F3, SERPINE1, SERPINC1
15
Hide members
8.1F5, FGA, F3, VWF, PLAT, SERPINE1
16
Hide members
7.3F5, FGA, F3, VWF, GP6, GP1BA

Compounds for genes affiliated with Coronary Thrombosis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1integrilin4410.0SERPINC1, PLAT, VWF
2reviparin4410.0F3, PLAT, SERPINC1
3aspartate4410.0SLC6A4
4warfarin44 49 11 2412.9FGA, SERPINC1, VWF
5efegatran449.8F3, PLAT, SERPINC1
6epsilon aminocaproic acid449.6SERPINE1, SERPINC1, F3, PLAT
7desirudin449.6F3, PLAT, FGA
8fucoidan449.6PLAT, F3, SERPINE1, SERPINC1
9tranexamic acid44 1110.5SERPINC1, VWF, SERPINE1, PLAT, F3
10spectrozyme449.4PLAT, F3, F5, SERPINC1
11inogatran449.4SERPINC1, F3, F5
12fondaparinux449.4SERPINC1, F5, F3, PLAT
13protamine sulfate449.4F5, F3, PLAT, SERPINC1
14tirofiban44 1110.3F3, P2RY12, ITGB3, SERPINC1, VWF, PLAT
15clopidogrel49 44 11 2412.3SERPINC1, ITGB3, F3, VWF, P2RY12, PLAT
16batroxobin449.2PLAT, FGA, SERPINE1, F5
17serine449.2FGA, GP1BA, SLC6A4, SERPINF1
18hirugen449.2SERPINC1, FGA, F5
19raloxifene44 28 49 1112.1SERPINC1, SERPINE1, SLC6A4, F5
20levonorgestrel44 59 28 1112.1SERPINC1, PLAT, F3, F5
21dermatan sulfate449.1SERPINC1, PLAT, VWF, F3, F5
22ppack449.1F3, VWF, P2RY12, PLAT, SERPINC1, FGA
23ticlopidine44 1110.1F3, FGA, VWF, P2RY12, PLAT, SERPINC1
24ancrod449.0SERPINE1, SERPINC1, PLAT, FGA, F5
25convulxin449.0GP6, GP1BA, F5, P2RY12
26ecarin449.0F3, SERPINC1, F5
27bivalirudin44 1110.0FGA, F3, SERPINC1, F5, PLAT
28argatroban44 1110.0PLAT, SERPINC1, F3, FGA, F5
29abciximab44 119.9SERPINC1, PLAT, GP1BA, ITGB3, F3, VWF
30heparin44 28 11 2411.9SERPINF1, GP1BA, P2RY12, FGA, POU2F3
31adp44 28 2410.9P2RY12, PLAT, FGA, SLC6A4, GP6
32homocysteine44 249.9VWF, PLAT, SERPINE1, SERPINC1, F3, F5
33creatinine448.8F5, FGA, GP6, F3, P2RY12
34protamine448.7SERPINC1, SERPINE1, PLAT, F5, FGA, F3
35pge1448.6P2RY12, VWF, PLAT, SERPINE1, FGA, F5
36kininogen448.6F5, F3, VWF, GP1BA, PLAT, SERPINE1
37phosphatidylserine44 28 1110.5F5, ITGB3, F3, VWF, GP6, GP1BA
38simvastatin44 49 59 28 11 2413.5VWF, F5, SERPINE1, SLC6A4, F3, PLAT
39aprotinin44 119.5F5, FGA, F3, VWF, PLAT, SERPINE1
40thromboxane44 249.3VWF, FGA, P2RY12, GP6, PLAT, PTGS2
41thromboxane a244 249.3GP6, FGA, PLAT, VWF, P2RY12, PTGS2
42ristocetin448.2ITGB3, F5, F3, VWF, GP1BA, PLAT
43hirudin448.1GP1BA, PLAT, SERPINE1, SERPINC1, F3, VWF
44desmopressin44 59 28 1110.8PLAT, PTGS2, SERPINE1, SERPINC1, GP1BA, VWF
45epinephrine44 11 249.6FGA, F3, VWF, P2RY12, GP6, GP1BA
46vegf447.6ITGB3, F3, VWF, SERPINF1, SERPINC1, PTGS2
47alanine447.4ITGB3, F5, F3, GP1BA, SLC6A4, GP6
48prostacyclin447.3SERPINC1, SERPINE1, PTGS2, F5, FGA, F3
49fibrinogen447.2VWF, F3, FGA, F5, ITGB3, P2RY12
50aspirin44 49 28 249.3F3, FGA, F5, ITGB3, VWF, SERPINC1

GO Terms for genes affiliated with Coronary Thrombosis

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16Gene Ontology
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Cellular components related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:0310919.8VWF, FGA
2extracellular matrixGO:0310129.1SERPINE1, SERPINF1, PLAT, VWF, F3
3platelet alpha granule lumenGO:0310939.0F5, FGA, VWF, SERPINE1
4extracellular spaceGO:0056158.0F5, FGA, F3, PLAT, SERPINE1, SERPINC1
5extracellular regionGO:0055767.7SERPINC1, SERPINE1, PLAT, VWF, FGA, F5
6plasma membraneGO:0058866.6ITGB3, F5, FGA, F3, P2RY12, GP6

Biological processes related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:01490910.1PLAT, ITGB3
2hemostasisGO:0075999.9P2RY12, VWF
3platelet aggregationGO:0705279.8P2RY12, ITGB3
4fibrinolysisGO:0427309.7SERPINE1, PLAT, GP1BA
5negative regulation of endopeptidase activityGO:0109519.7SERPINE1, SERPINC1, SERPINF1
6blood coagulation, intrinsic pathwayGO:0075979.5VWF, GP1BA
7negative regulation of synaptic transmission, dopaminergicGO:0322279.3SLC6A4, PTGS2
8cell adhesionGO:0071559.0GP1BA, VWF, F5, ITGB3
9platelet degranulationGO:0025768.8ITGB3, F5, FGA, VWF, SERPINE1
10platelet activationGO:0301687.7ITGB3, F5, FGA, VWF, P2RY12, GP6
11blood coagulationGO:0075967.0SERPINC1, ITGB3, F5, FGA, F3, VWF

Molecular functions related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.6SERPINF1, SERPINC1, SERPINE1
2protease bindingGO:0020209.3SERPINC1, SERPINE1, VWF, F3
3protein bindingGO:0055155.7F3, FGA, POU2F3, F5, ITGB3, VWF

Products for genes affiliated with Coronary Thrombosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coronary Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet