MCID: CRN017
MIFTS: 60

Coronary Thrombosis malady

Cardiovascular diseases, Blood diseases categories
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Summaries for Coronary Thrombosis

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Wikipedia:65 Coronary thrombosis is the formation of a blood clot inside a blood vessel of the heart due to various... more...

MalaCards based summary: Coronary Thrombosis, also known as coronary artery thrombosis, is related to purpura and thrombocytosis. An important gene associated with Coronary Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and GP1b-IX-V activation signalling. The drugs heparin and heparin sodium and the compounds reviparin and integrilin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related mouse phenotypes are muscle and liver/biliary system.

Aliases & Classifications for Coronary Thrombosis

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH
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Coronary Thrombosis, Aliases & Descriptions:

Name: Coronary Thrombosis 8 44 62
 
Coronary Artery Thrombosis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


External Ids:

Disease Ontology8 DOID:11847
MeSH34 D003328

Related Diseases for Coronary Thrombosis

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Diseases related to Coronary Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.3SERPINC1
2thrombocytosis30.6VWF, GP1BA, SERPINC1, F3, FGA
3antithrombin iii deficiency30.5SERPINC1, F5
4lupus erythematosus30.5F5, F3, SERPINC1
5acute myocardial infarction30.4VWF, SERPINE1, SERPINC1, F3, PLAT, SLC6A4
6antiphospholipid syndrome30.3VWF, SERPINC1, F3, PLAT, F5
7protein c deficiency30.3SERPINE1, SERPINC1, F5
8vascular disease30.2VWF, PTGS2, SERPINC1, F3
9pulmonary embolism30.1SERPINC1, F3, PLAT, F5, FGA
10diabetes mellitus30.1VWF, GP1BA, SERPINE1, SERPINC1, PLAT, FGA
11hyperglycemia30.0FGA, SERPINE1, SERPINF1
12protein s deficiency29.9SERPINE1, SERPINC1, F3, F5, FGA
13septic shock29.9SERPINE1, SERPINC1, F3, F5, FGA
14hypertension29.7SERPINE1, PLAT, F5, SLC6A4
15disseminated intravascular coagulation29.7SERPINE1, SERPINC1, F3, PLAT, F5, FGA
16thromboembolism29.7VWF, GP6, SERPINE1, SERPINC1, F3, PLAT
17atherosclerosis29.6SERPINE1, SERPINF1, PTGS2, VWF, SERPINC1, F3
18thrombophilia29.5SERPINC1, F3, PLAT, F5, FGA, SERPINE1
19thrombocytopenia29.3FGA, F5, ITGB3, F3, VWF, GP6
20myocardial infarction29.3PLAT, F5, SLC6A4, FGA, ITGB3, P2RY12
21central retinal artery occlusion10.6PLAT
22eclampsia10.6SERPINC1
23angiodysplasia10.6VWF
24sneddon syndrome10.5SERPINC1
25intermittent claudication10.5VWF
26endophthalmitis10.5PLAT
27afibrinogenemia10.5FGA
28hemophilia b10.4F3
29carotid artery thrombosis10.4SERPINE1, F3
30artery disease10.4
31intermediate coronary syndrome10.4SERPINC1, PLAT
32macular holes10.4SERPINF1
33hemarthrosis10.4VWF, F3
34pseudo-von willebrand disease10.4VWF, GP1BA
35branch retinal artery occlusion10.4F5
36hemorrhagic disease10.4SERPINE1, PLAT
37peripheral vascular disease10.3VWF, SERPINE1
38hemorrhage, intracerebral10.3F3, PLAT
39blood platelet disease10.3VWF, GP1BA
40ischemia10.3
41retinal vein occlusion10.3SERPINC1, F5
42central retinal vein occlusion10.3PLAT, F5
43sagittal sinus thrombosis10.3SERPINC1, F5
44meningococcemia10.3SERPINC1, F5
45thrombotic thrombocytopenic purpura, acquired10.3VWF, SERPINE1, F3
46patent foramen ovale10.3F5
47post-thrombotic syndrome10.3SERPINC1, F5
48legg-calve-perthes disease10.3SERPINC1, F5
49factor xi deficiency10.3F3, F5
50prothrombin deficiency10.3F5, SERPINC1

Graphical network of the top 20 diseases related to Coronary Thrombosis:



Diseases related to coronary thrombosis

Symptoms for Coronary Thrombosis

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Drugs & Therapeutics for Coronary Thrombosis

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Drug clinical trials:

Search ClinicalTrials for Coronary Thrombosis

Search NIH Clinical Center for Coronary Thrombosis

Inferred drug relations via UMLS62/NDF-RT40:

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Genetic Tests for Coronary Thrombosis

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Anatomical Context for Coronary Thrombosis

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MalaCards organs/tissues related to Coronary Thrombosis:

32
Heart, Lung, Testes, Brain, Adrenal gland

Animal Models for Coronary Thrombosis or affiliated genes

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Publications for Coronary Thrombosis

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Articles related to Coronary Thrombosis:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Multiple and Contemporary Coronary Thrombosis inspite of Low Platelet Function Response. (25302230)
2014
2
Acute coronary thrombosis and multiple coronary aneurysms in a 22-year-old man with the human immunodeficiency virus. (24808786)
2014
3
Antithrombotic effect of Z4A5 on coronary thrombosis in a canine model of acute unstable angina. (23083032)
2013
4
Detection of coronary thrombosis after multi-phase postmortem CT-angiography. (22981180)
2013
5
Simultaneous double coronary thrombosis in a 47-year-old male patient with acute myocardial infarction. (24175009)
2013
6
Right coronary thrombosis in patient supported by Jarvik 2000 left ventricular assist device. (21071239)
2011
7
Acute coronary thrombosis in a patient with diabetes and severe hyperglycemia. (19536400)
2009
8
Clinically relevant concentrations of dopamine do not amplify agonist-induced human platelet Ca2+ mobilization or GP IIb IIIa activation and do not accelerate acute coronary thrombosis in dogs. (19247190)
2009
9
Incidence of asymptomatic coronary thrombosis and plaque disruption: comparison of non-cardiac and cardiac deaths among autopsy cases. (19000633)
2009
10
The success of clopidogrel treatment for recurrent coronary thrombosis in a patient with aortic and mitral valve replacement. (18160612)
2008
11
Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. (15306180)
2004
12
Coronary thrombosis associated with inherited protein S deficiency: a case report. (9013223)
1997
13
Platelet glycoprotein IIIa polymorphism and coronary thrombosis. (9652554)
1997
14
Human platelet Ca2+ mobilization, glycoprotein IIb/IIIa activation, and experimental coronary thrombosis in vivo in dogs are all inhibited by the inotropic agent amrinone. (9315560)
1997
15
Absence of correlation between coronary thrombosis and postatherectomy restenosis. (9193022)
1997
16
Coronary thrombosis. (8918520)
1996
17
Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. (8641024)
1996
18
'STAR' war against coronary thrombosis. (8714497)
1995
19
Comparison of hirudin and heparin as adjuncts to streptokinase thrombolysis in a canine model of coronary thrombosis. (8477521)
1993
20
An autopsy case of Kawasaki disease with reference to occurrence of acute coronary thrombosis in the convalescent stage. (1449055)
1992
21
Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis. (1689620)
1990
22
Triggers of transient myocardial ischemia: circadian variation and relation to plaque rupture and coronary thrombosis in stable coronary artery disease. (2239711)
1990
23
Therapeutic trials in coronary thrombosis should measure left ventricular function as primary end-point of treatment. (2891942)
1988
24
Effects of 3-methoxycyproheptadine in a canine model of coronary thrombosis. (3183974)
1988
25
Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty. (2954724)
1987
26
Asynchronous left ventricular wall motion early after coronary thrombosis. (3947480)
1986
27
Exercise-induced myocardial infarction due to coronary thrombosis. (3976482)
1985
28
Prevention of coronary thrombosis with subthrombolytic doses of tissue-type plasminogen activator. (3933849)
1985
29
A review of research into the experience of patients suffering from coronary thrombosis. (255457)
1979
30
Home or hospital care for coronary thrombosis? (667559)
1978
31
The relationship between coronary artery lesions and myocardial infarcts: ulceration of atherosclerotic plaques precipitating coronary thrombosis. (842443)
1977
32
Effect of experimental coronary thrombosis upon platelet kinetics. (4773372)
1973
33
Fibrinolytic activity in coronary artery disease and myocardial infarction, and the role of fibrinolytic therapy in coronary thrombosis. (5648576)
1968
34
The consequences of coronary thrombosis. (6079335)
1967
35
Coronary thrombosis and myocardial infarction. (4162544)
1966
36
LOW INCIDENCE OF CORONARY THROMBOSIS IN MYOCARDIAL INFARCTION. A RESTUDY BY SERIAL BLOCK TECHNIQUE. (14184673)
1964
37
CORONARY THROMBOSIS IN MYOCARDIAL INFARCTION. (14246597)
1964
38
EMOTIONAL REACTIONS TO INITIAL ATTACKS OF CORONARY THROMBOSIS. (14132354)
1964
39
Physical effort and emotion in acute coronary thrombosis. (13959728)
1963
40
Experimental myocardial infarction. Induction of coronary thrombosis in the intact closed-chest dog. (14496296)
1961
41
Successful cardiac massage for cardiac arrest following coronary thrombosis. (13842766)
1960
42
Note on a case of coronary thrombosis at an unusually early age. (14413560)
1960
43
The failure of anticoagulant therapy to prevent coronary thrombosis after long-term use and in impending myocardial infarction (with case reports). (13811495)
1959
44
Further observations concerning the prognosis of myocardial infarction due to coronary thrombosis. (13488214)
1958
45
Coronary thrombosis in general practice. (13465575)
1957
46
Coronary thrombosis. (13269933)
1955
47
Coronary thrombosis in a five-month-old infant. (14354590)
1955
48
Coronary thrombosis; a comparative study of 270 cases. (13199832)
1954
49
Experiences with aspirin (Acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis. (13013156)
1953
50
Long term dicumarol therapy in thromboembolic conditions, especially coronary thrombosis. (13091736)
1953

Variations for Coronary Thrombosis

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Expression for genes affiliated with Coronary Thrombosis

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Expression patterns in normal tissues for genes affiliated with Coronary Thrombosis

Search GEO for disease gene expression data for Coronary Thrombosis.

Pathways for genes affiliated with Coronary Thrombosis

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Pathways related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLAT, SERPINE1
29.8GP1BA, VWF
3
Show member pathways
Serotonin Transporter Activity37
9.6SLC6A4, ITGB3
4
Show member pathways
9.5SERPINE1, PLAT, FGA
59.5GP1BA, GP6, VWF
6
Show member pathways
9.2VWF, GP1BA, ITGB3, FGA
7
Show member pathways
thioredoxin pathway37
9.1PLAT, SERPINE1, PTGS2
8
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1F3, SERPINE1, PTGS2
9
Show member pathways
9.0SERPINC1, F3, F5, FGA
108.8VWF, GP6, P2RY12, ITGB3, FGA
11
Show member pathways
8.7FGA, F5, ITGB3, SERPINE1, VWF
12
Show member pathways
8.7VWF, SERPINE1, P2RY12, ITGB3, PLAT, FGA
13
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.4VWF, GP6, GP1BA, PTGS2, ITGB3
14
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.2VWF, SERPINE1, SERPINC1, F3, PLAT, F5
15
Show member pathways
7.5F5, PLAT, F3, SERPINC1, SERPINE1, GP1BA
16
Show member pathways
6.9FGA, VWF, GP6, F5, PLAT, ITGB3

Compounds for genes affiliated with Coronary Thrombosis

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Compounds related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1reviparin449.9SERPINC1, PLAT, F3
2integrilin449.9PLAT, SERPINC1, VWF
3efegatran449.7PLAT, F3, SERPINC1
4epsilon aminocaproic acid449.7PLAT, F3, SERPINC1, SERPINE1
5desirudin449.6PLAT, F3, FGA
6fucoidan449.6F3, SERPINC1, SERPINE1, PLAT
7spectrozyme449.6F3, PLAT, F5, SERPINC1
8fondaparinux449.5F5, SERPINC1, PLAT, F3
9tranexamic acid44 1110.5F3, SERPINC1, SERPINE1, VWF, PLAT
10protamine sulfate449.5SERPINC1, F5, PLAT, F3
11ecarin449.5F5, F3, SERPINC1
12inogatran449.4SERPINC1, F3, F5
13batroxobin449.3PLAT, F5, FGA, SERPINE1
14levonorgestrel44 61 28 1112.3F3, SERPINC1, PLAT, F5
15tirofiban44 1110.3VWF, SERPINC1, F3, P2RY12, PLAT, ITGB3
16clopidogrel44 50 24 1112.3VWF, P2RY12, ITGB3, PLAT, F3, SERPINC1
17dermatan sulfate449.2PLAT, VWF, F5, SERPINC1, F3
18convulxin449.2GP1BA, F5, GP6, P2RY12
19bivalirudin44 1110.2F5, FGA, PLAT, F3, SERPINC1
20argatroban44 1110.2FGA, F5, PLAT, F3, SERPINC1
21ancrod449.2SERPINC1, SERPINE1, PLAT, F5, FGA
22ppack449.1FGA, PLAT, P2RY12, F3, SERPINC1, VWF
23ticlopidine44 1110.1PLAT, FGA, P2RY12, F3, SERPINC1, VWF
24abciximab44 1110.0PLAT, P2RY12, ITGB3, GP1BA, VWF, SERPINC1
25homocysteine44 2410.0PLAT, VWF, F5, F3, SERPINC1, SERPINE1
26protamine448.9F5, PLAT, F3, SERPINC1, SERPINE1, FGA
27warfarin44 50 24 1111.9F3, F5, PLAT, FGA, VWF, SERPINC1
28raloxifene44 50 28 1111.8SERPINC1, SERPINE1, VWF, F5, SLC6A4
29pge1448.8PLAT, SERPINE1, P2RY12, VWF, FGA, F5
30phosphatidylserine44 28 1110.7VWF, F5, ITGB3, F3, GP1BA, GP6
31kininogen448.7GP1BA, VWF, F5, PLAT, F3, SERPINC1
32simvastatin44 50 61 28 24 1113.6VWF, SERPINE1, F3, PLAT, F5, SLC6A4
33ristocetin448.4ITGB3, PLAT, F5, F3, SERPINC1, VWF
34thromboxane44 249.4FGA, VWF, GP6, PTGS2, P2RY12, PLAT
35thromboxane a244 249.4P2RY12, PTGS2, GP6, PLAT, FGA, VWF
36hirudin448.3FGA, F5, PLAT, F3, SERPINC1, SERPINE1
37aprotinin44 119.3FGA, F5, PLAT, F3, SERPINC1, SERPINE1
38aspartate448.2SLC6A4, VWF, F5, F3, PLAT, SERPINE1
39creatinine447.9VWF, GP6, SERPINE1, SERPINC1, F3, PLAT
40desmopressin44 61 28 1110.9PLAT, F5, F3, SERPINC1, VWF, GP1BA
41alanine447.8F5, GP6, VWF, SLC6A4, GP1BA, ITGB3
42epinephrine44 24 119.7GP1BA, F3, GP6, VWF, P2RY12, FGA
43vegf447.6SERPINE1, F5, PTGS2, ITGB3, SERPINF1, VWF
44adp44 28 249.5VWF, SLC6A4, FGA, PLAT, ITGB3, P2RY12
45prostacyclin447.5FGA, F5, PLAT, F3, SERPINC1, SERPINE1
46fibrinogen447.4FGA, F5, PLAT, ITGB3, P2RY12, F3
47cysteine447.2SLC6A4, PLAT, ITGB3, F3, SERPINF1, GP6
48heparin44 28 24 1110.0FGA, SERPINC1, F5, PLAT, P2RY12, F3
49serine446.6GP6, SERPINC1, SERPINE1, SERPINF1, F3, ITGB3
50aspirin44 50 28 249.5SERPINE1, PTGS2, GP1BA, GP6, VWF, SERPINC1

GO Terms for genes affiliated with Coronary Thrombosis

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Cellular components related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:0310919.5FGA, VWF
2external side of plasma membraneGO:0098979.5FGA, P2RY12, VWF
3platelet alpha granule lumenGO:0310939.1VWF, SERPINE1, F5, FGA
4extracellular matrixGO:0310129.1PLAT, F3, SERPINE1, SERPINF1, VWF
5extracellular spaceGO:0056158.1SERPINF1, SERPINE1, SERPINC1, F3, PLAT, F5
6extracellular regionGO:0055767.9VWF, SERPINF1, SERPINE1, SERPINC1, PLAT, F5
7plasma membraneGO:0058866.8GP6, GP1BA, SERPINE1, SERPINC1, F3, P2RY12

Biological processes related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:01490910.2PLAT, ITGB3
2platelet aggregationGO:0705279.9ITGB3, P2RY12
3hemostasisGO:0075999.9P2RY12, VWF
4fibrinolysisGO:0427309.8GP1BA, SERPINE1, PLAT
5negative regulation of endopeptidase activityGO:0109519.6SERPINF1, SERPINE1, SERPINC1
6blood coagulation, intrinsic pathwayGO:0075979.5GP1BA, VWF
7extracellular matrix organizationGO:0301989.4FGA, ITGB3, SERPINE1, VWF
8negative regulation of synaptic transmission, dopaminergicGO:0322279.2SLC6A4, PTGS2
9response to glucocorticoidGO:0513849.1PTGS2, SERPINF1, PLAT
10cell adhesionGO:0071559.0VWF, GP1BA, ITGB3, F5
11platelet degranulationGO:0025769.0VWF, SERPINE1, ITGB3, F5, FGA
12platelet activationGO:0301687.9VWF, GP6, GP1BA, SERPINE1, P2RY12, ITGB3
13blood coagulationGO:0075967.2FGA, VWF, GP6, GP1BA, SERPINE1, SERPINC1

Molecular functions related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.5SERPINC1, SERPINE1, SERPINF1
2protease bindingGO:0020209.3F3, SERPINC1, SERPINE1, VWF
3protein bindingGO:0055155.8SERPINC1, SERPINE1, GP1BA, GP6, VWF, POU2F3

Products for genes affiliated with Coronary Thrombosis

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  • Antibodies
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Sources for Coronary Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet