MCID: CRN017
MIFTS: 48

Coronary Thrombosis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Coronary Thrombosis

MalaCards integrated aliases for Coronary Thrombosis:

Name: Coronary Thrombosis 12 51 41 14 69
Coronary Artery Thrombosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11847
ICD10 32 I21 I22
MeSH 41 D003328
UMLS 69 C0010072

Summaries for Coronary Thrombosis

MalaCards based summary : Coronary Thrombosis, also known as coronary artery thrombosis, is related to heparin-induced thrombocytopenia and coronary artery anomaly. An important gene associated with Coronary Thrombosis is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and ECM-receptor interaction. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, neutrophil and myeloid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Coronary thrombosis is the formation of a blood clot inside a blood vessel of the heart. This blood clot... more...

Related Diseases for Coronary Thrombosis

Diseases related to Coronary Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 heparin-induced thrombocytopenia 29.8 F3 SERPINC1
2 coronary artery anomaly 29.8 P2RY12 PLAT SERPINE1
3 protein s deficiency 29.5 F3 SERPINC1
4 antiphospholipid syndrome 29.4 F3 PLAT SERPINC1
5 thrombosis 29.4 F3 GP1BA PLAT SERPINC1 SERPINE1 VWF
6 thrombocytopenia 29.3 F3 GP1BA ITGB3
7 thrombocytosis 29.2 F3 SERPINC1
8 thrombotic thrombocytopenic purpura 28.9 F3 VWF
9 acute myocardial infarction 28.9 F3 PLAT SERPINC1 SERPINE1 VWF
10 pulmonary embolism 28.7 F3 PLAT SERPINC1 SERPINE1
11 essential thrombocythemia 28.4 F3 ITGB3 SERPINE1 VWF
12 disseminated intravascular coagulation 28.4 F3 PLAT SERPINC1 SERPINE1
13 purpura 28.4 F3 GP1BA ITGB3 SERPINC1 VWF
14 arteries, anomalies of 27.9 F3 P2RY12 PLAT SERPINC1 SERPINE1 VWF
15 angina pectoris 27.9 F3 PLAT SERPINC1 SERPINE1 VWF
16 thrombophilia 27.8 F3 PLAT SERPINC1 SERPINE1 VWF
17 vascular disease 27.8 F3 PLAT SERPINC1 SERPINE1 VWF
18 myocardial infarction 27.4 F3 GP1BA GP6 ITGB3 P2RY12 PLAT
19 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.9
20 sudden sensorineural hearing loss 10.4 ITGB3 SERPINC1
21 posterior myocardial infarction 10.4 PLAT SERPINC1
22 encephalopathy, familial, with neuroserpin inclusion bodies 10.4 PLAT SERPINC1
23 fetal and neonatal alloimmune thrombocytopenia 10.4 GP1BA ITGB3
24 autosomal dominant macrothrombocytopenia 10.4 GP1BA ITGB3
25 dysfibrinogenemia 10.3 PLAT SERPINC1
26 eisenmenger syndrome 10.3 PLAT VWF
27 arteritic anterior ischemic optic neuropathy 10.3 GP1BA ITGB3
28 clopidogrel resistance 10.3 ITGB3 P2RY12
29 pseudo-von willebrand disease 10.3 GP1BA VWF
30 acquired von willebrand syndrome 10.2 GP1BA VWF
31 plasminogen activator inhibitor-1 deficiency 10.2 PLAT SERPINE1
32 von willebrand disease, type 3 10.2 GP1BA VWF
33 autoimmune disease of blood 10.2 ITGB3 VWF
34 central serous chorioretinopathy 10.2 PLAT SERPINE1
35 acute cor pulmonale 10.2 PLAT SERPINE1
36 acute pulmonary heart disease 10.2 PLAT SERPINE1
37 ischemic colitis 10.2 SERPINC1 SERPINE1
38 subendocardial myocardial infarction 10.2 SERPINC1 SERPINE1
39 retinal artery occlusion 10.2 SERPINC1 SERPINE1
40 nonarteritic anterior ischemic optic neuropathy 10.2 GP1BA SERPINC1
41 meningococcemia 10.2 SERPINC1 SERPINE1
42 post-thrombotic syndrome 10.1 SERPINC1 SERPINE1
43 legg-calve-perthes disease 10.1 SERPINC1 SERPINE1
44 chronic venous insufficiency 10.1 PLAT SERPINE1
45 ischemic optic neuropathy 10.1 GP1BA ITGB3 SERPINC1
46 portal vein thrombosis 10.1 SERPINC1 SERPINE1
47 platelet aggregation, spontaneous 10.1 PLAT SERPINC1 VWF
48 intracranial sinus thrombosis 10.1 F3 SERPINC1
49 intestinal impaction 10.1 F3 SERPINC1
50 fournier gangrene 10.0 F3 SERPINC1

Graphical network of the top 20 diseases related to Coronary Thrombosis:



Diseases related to Coronary Thrombosis

Symptoms & Phenotypes for Coronary Thrombosis

MGI Mouse Phenotypes related to Coronary Thrombosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 PLAT SERPINC1 SERPINE1 VWF F3 GP1BA
2 homeostasis/metabolism MP:0005376 9.81 F3 GP1BA GP6 ITGB3 P2RY12 PLAT
3 cardiovascular system MP:0005385 9.8 F3 ITGB3 PLAT SERPINC1 SERPINE1 VWF
4 immune system MP:0005387 9.5 F3 GP6 ITGB3 PLAT SERPINC1 SERPINE1
5 vision/eye MP:0005391 9.02 ITGB3 PLAT SERPINC1 F3 GP6

Drugs & Therapeutics for Coronary Thrombosis

Drugs for Coronary Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
2
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
3
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 46835353 6436030 5284616
6
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
7
Tirofiban Approved Phase 4 144494-65-5 60947
8 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
9 Anti-Infective Agents Phase 4,Phase 1,Phase 2
10 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
11 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2
12 Antifungal Agents Phase 4,Phase 1,Phase 2
13 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
14 Anticholesteremic Agents Phase 4
15 Antimetabolites Phase 4
16 Atorvastatin Calcium Phase 4 134523-03-8
17 Calcium, Dietary Phase 4
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
19 Hypolipidemic Agents Phase 4
20 Lipid Regulating Agents Phase 4
21 Analgesics Phase 4,Phase 3
22 Analgesics, Non-Narcotic Phase 4,Phase 3
23 Anti-Asthmatic Agents Phase 4
24 Anti-Inflammatory Agents Phase 4,Phase 3
25 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
26 Antipyretics Phase 4,Phase 3
27 Antirheumatic Agents Phase 4,Phase 3
28 Autonomic Agents Phase 4
29 Bronchodilator Agents Phase 4
30 Cyclooxygenase Inhibitors Phase 4,Phase 3
31 Fibrinolytic Agents Phase 4,Phase 3
32 Neuroprotective Agents Phase 4
33 Peripheral Nervous System Agents Phase 4,Phase 3
34 Phosphodiesterase 3 Inhibitors Phase 4
35 Phosphodiesterase Inhibitors Phase 4
36 Protective Agents Phase 4
37 Respiratory System Agents Phase 4
38 Vasodilator Agents Phase 4
39 Antacids Phase 4,Phase 3
40 Anti-Ulcer Agents Phase 4,Phase 3
41 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
42 Gastrointestinal Agents Phase 4,Phase 3
43 Proton pump inhibitors Phase 4,Phase 3
44
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
45
Ticlopidine Approved Phase 3 55142-85-3 5472
46 Neurotransmitter Agents Phase 3
47 Purinergic P2 Receptor Antagonists Phase 3
48 Purinergic P2Y Receptor Antagonists Phase 3
49 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid Phase 3
50 Lipoxygenase Inhibitors Phase 3

Interventional clinical trials:

(show all 24)

# Name Status NCT ID Phase Drugs
1 Scripps Evaluation of Antiplatelet Therapies for Intermediate Duration With the Endeavor Stent (Seaside) Unknown status NCT00963781 Phase 4 Reduced duration (6 months) DAPT
2 Monitoring Response to Antiplatelet Therapy Unknown status NCT00327041 Phase 4
3 Safety and Efficacy Study Comparing 3 New Types of Coronary Stents Completed NCT01166685 Phase 4
4 Atorvastatin in Acute Stroke Treatment Completed NCT02225834 Phase 4 Atorvastatin
5 Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients Not yet recruiting NCT02933788 Phase 4 Cilostazol;Acetylsalicylic acid
6 Comparison of Two Treatment Strategies in Patients With an Acute Coronary Syndrome Without ST Elevation Terminated NCT00445263 Phase 4 TIROFIBAN
7 Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control Withdrawn NCT00713947 Phase 4 during one week for the active treatments;Pantoprazole;Placebo Formula 515
8 Veliflapon (DG-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina Suspended NCT00353067 Phase 3 veliflapon (DG-031)
9 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
10 OCT Evaluation of Healing of COMBO Stent Completed NCT01274234 Phase 1, Phase 2
11 A Double-Blind Study of E5555 in Japanese Patients With Acute Coronary Syndrome Completed NCT00619164 Phase 2 E5555;E5555;E5555;Placebo
12 Periprocedural Myocardial Infarction: the Role of Human Neutrophil Peptide-1 to 3 Unknown status NCT02591264
13 Angiographic and Intravascular Ultrasound (IVUS) Follow-up After Simultaneously Implanted Different Drug-eluting Stents in Same Individuals Unknown status NCT00973375
14 Independent OCT Registry on Very Late Bioresorbable Scaffold Thrombosis Completed NCT03180931
15 The SCRIPPS DES REAL WORLD Registry Completed NCT00714623
16 Platelet Acetyl Coenzyme A Carboxylase Phosphorylation in Coronary Artery Disease Completed NCT03034148
17 Xtractâ„¢ Aspiration Catheter Registry Study Completed NCT00349570
18 The Cholesterol-lowering Efficacy of Probiotic Lactobacillus Plantarum in Hypercholesterolaemic Adults Completed NCT03263104
19 Assessment of Coagulation and Thrombocyte Function After Termination of Ticagrelor Completed NCT02297971
20 Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement Completed NCT00657436
21 Optical Coherence Tomography in Patients With Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease Completed NCT02783963
22 Assessment of Thrombotic Status in Patients With Acute Coronary Syndrome Recruiting NCT02562690
23 OFDI-Quantified Intracoronary Thrombus, Antiplatelet Pretreatment Effect and Myocardial Reperfusion Recruiting NCT03342521
24 Myocardial Injury Following Non-cardiac Surgery Not yet recruiting NCT03317561

Search NIH Clinical Center for Coronary Thrombosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: coronary thrombosis

Genetic Tests for Coronary Thrombosis

Anatomical Context for Coronary Thrombosis

MalaCards organs/tissues related to Coronary Thrombosis:

38
Heart, Neutrophil, Myeloid, Lung, Testes, Endothelial, Adrenal Gland

Publications for Coronary Thrombosis

Articles related to Coronary Thrombosis:

(show top 50) (show all 522)
# Title Authors Year
1
rLj-RGD3, a novel recombinant toxin protein from Lampetra japonica, prevents coronary thrombosis-induced acute myocardial infarction by inhibiting platelet functions in rats. ( 29407168 )
2018
2
Tissue plasminogen activator for neonatal coronary thrombosis presenting with mitral valve regurgitation and impaired ventricular function. ( 28140523 )
2017
3
Therapeutic application of contrast ultrasound in ST elevation myocardial infarction: Role in coronary thrombosis and microvascular obstruction. ( 28868906 )
2017
4
Sex differences in the effect of diabetes mellitus on platelet reactivity and coronary thrombosis: From the Assessment of Dual Antiplatelet Therapy with Drug-Eluting Stents (ADAPT-DES) study. ( 28867009 )
2017
5
Perioperative Coronary Thrombosis in a Patient With Multiple Second-Generation Drug-Eluting Stents: Is It Time for a Paradigm Shift? ( 27543999 )
2016
6
A rare cause of acute coronary syndrome: Coronary thrombosis in three coronary arteries due to whey protein. ( 27839839 )
2016
7
Coronary Thrombosis and Major Bleeding After PCI With Drug-Eluting Stents: Risk Scores From PARIS. ( 27079334 )
2016
8
Coronary Thrombosis without Dissection following Blunt Trauma. ( 27006836 )
2016
9
Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature. ( 26607055 )
2016
10
Coronary thrombosis in diabetes: Are we doing enough? ( 27555606 )
2016
11
Early Post-Operative Coronary Thrombosis Following Repair of a Proximal Coronary Artery Fistula. ( 28208917 )
2016
12
Multifocal coronary thrombosis on nondisrupted plaque: observation with optical coherence tomography. ( 27159264 )
2016
13
Translation from the data of clinical trials to precision medicine: limitation of the current risk score for predicting coronary thrombosis and major bleeding. ( 27746980 )
2016
14
Endothelial erosion of plaques as a substrate for coronary thrombosis. ( 26791872 )
2016
15
Multiple coronary thrombosis. ( 27489604 )
2016
16
Early Coronary Thrombosis without ST-Segment Elevation Following Repair of Acute Aortic Dissection. ( 28097197 )
2016
17
Acute Myocardial Infarction in a Neonate Caused by a Coronary Thrombosis: a Considerable Diagnostic and Therapeutic Challenge. ( 26297178 )
2015
18
Coronary Thrombosis and Type A Aortic Dissection. ( 25980980 )
2015
19
Resolution of Extensive Coronary Thrombosis under Rivaroxaban Treatment. ( 26761372 )
2015
20
Simultaneous multi-vessel coronary thrombosis in patients with ST-elevation myocardial infarction: a systematic review. ( 25772369 )
2015
21
Evading the fate of Pheidippides: acute coronary thrombosis in a young marathon runner with minimal atherosclerosis but sickle cell trait. ( 26331117 )
2015
22
Multiple and Contemporary Coronary Thrombosis inspite of Low Platelet Function Response. ( 25302230 )
2014
23
Low-Dose Antithrombotic Treatment in Coronary Thrombosis of Kawasaki Disease. ( 25298222 )
2014
24
Acute ST Elevated Myocardial Injury due to Coronary Thrombosis during Thoracic Endovascular Aortic Repair in Patient with Protein S Deficiency. ( 25469146 )
2014
25
Acute myocardial infarction due to coronary thrombosis caused by blunt chest trauma. ( 24769662 )
2014
26
Acute coronary thrombosis and multiple coronary aneurysms in a 22-year-old man with the human immunodeficiency virus. ( 24808786 )
2014
27
Detection of coronary thrombosis after multi-phase postmortem CT-angiography. ( 22981180 )
2013
28
Varenicline-induced coronary thrombosis. ( 24259623 )
2013
29
Regadenoson induced acute ST-segment elevation myocardial infarction and multivessel coronary thrombosis. ( 23460076 )
2013
30
Coronary thrombosis from large, nonprotruding, superficial calcified coronary plaques. ( 24080108 )
2013
31
Simultaneous double coronary thrombosis in a 47-year-old male patient with acute myocardial infarction. ( 24175009 )
2013
32
Bi-ostial coronary thrombosis due to heparin induced thrombocytopenia. ( 22664366 )
2013
33
Mechanisms of coronary thrombosis in cigarette smoke exposure. ( 23685556 )
2013
34
Antithrombotic effect of Z4A5 on coronary thrombosis in a canine model of acute unstable angina. ( 23083032 )
2013
35
Acute coronary thrombosis in Boston marathon runners. ( 22236231 )
2012
36
Calcified nodules: an underrated mechanism of coronary thrombosis? ( 23058076 )
2012
37
Cannabis and coronary thrombosis: What is the role of platelets? ( 21806494 )
2012
38
Acute coronary thrombosis after anaphylactic shock treatment. ( 22541413 )
2012
39
Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case study. ( 22684577 )
2012
40
Coronary thrombosis as the first complication of antiphospholipid syndrome. ( 22735914 )
2012
41
Does sildenafil contribute to acute coronary thrombosis? ( 23363902 )
2012
42
Primary percutaneous coronary intervention and intravascular ultrasound imaging for coronary thrombosis after cisplatin-based chemotherapy. ( 22218740 )
2012
43
Myocardial infarction due to coronary thrombosis in a patient with Henoch-SchAPnlein purpura. ( 22361720 )
2012
44
Proteomic profiling of acute coronary thrombosis reveals a local decrease in pigment epithelium-derived factor in acute myocardial infarction. ( 22315956 )
2012
45
Diastolic timed Vibro-Percussion at 50 Hz delivered across a chest wall sized meat barrier enhances clot dissolution and remotely administered Streptokinase effectiveness in an in-vitro model of acute coronary thrombosis. ( 23146079 )
2012
46
Multivessel coronary thrombosis in a patient with idiopathic thrombocytopenic purpura. ( 23304046 )
2012
47
Right coronary thrombosis in patient supported by Jarvik 2000 left ventricular assist device. ( 21071239 )
2011
48
Role of platelet glycoprotein receptor IIIa PI(A2) and traditional risk factors in the etiology of coronary thrombosis. ( 21816456 )
2011
49
Coronary thrombosis and myocardial infarction as the initial manifestation of protein C deficiency in a 20-year-old man. ( 21481934 )
2011
50
A study to determine chest wall vibratory attachment interface locations for a low frequency sonic vibrator in treatment of acute coronary thrombosis. ( 21547406 )
2011

Variations for Coronary Thrombosis

Expression for Coronary Thrombosis

Search GEO for disease gene expression data for Coronary Thrombosis.

Pathways for Coronary Thrombosis

Pathways related to Coronary Thrombosis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 F3 GP1BA GP6 ITGB3 P2RY12 PLAT
2
Show member pathways
11.88 GP1BA GP6 ITGB3 VWF
3 11.8 F3 PLAT SERPINC1 SERPINE1 VWF
4 11.77 F3 ITGB3 SERPINE1
5 11.64 GP1BA GP6 ITGB3 P2RY12 VWF
6
Show member pathways
11.62 GP1BA ITGB3 VWF
7 11.55 F3 ITGB3 VWF
8
Show member pathways
11.37 F3 GP1BA GP6 PLAT SERPINC1 SERPINE1
9 11.33 GP6 ITGB3 P2RY12 VWF
10 11.29 ITGB3 SERPINE1
11 11.21 GP1BA PLAT
12 10.66 GP1BA GP6 VWF
13 10.61 PLAT SERPINE1
14 10.48 GP1BA VWF

GO Terms for Coronary Thrombosis

Cellular components related to Coronary Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 F3 GP1BA GP6 ITGB3 PLAT SERPINC1
2 extracellular matrix GO:0031012 9.46 F3 PLAT SERPINE1 VWF
3 cell surface GO:0009986 9.1 F3 GP1BA GP6 ITGB3 P2RY12 PLAT

Biological processes related to Coronary Thrombosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.65 ITGB3 SERPINE1 VWF
2 platelet activation GO:0030168 9.55 GP1BA GP6 ITGB3 P2RY12 VWF
3 platelet degranulation GO:0002576 9.54 ITGB3 SERPINE1 VWF
4 platelet aggregation GO:0070527 9.49 ITGB3 P2RY12
5 regulation of blood coagulation GO:0030193 9.46 GP1BA SERPINC1
6 blood coagulation, intrinsic pathway GO:0007597 9.43 GP1BA VWF
7 fibrinolysis GO:0042730 9.43 GP1BA PLAT SERPINE1
8 hemostasis GO:0007599 9.43 F3 GP1BA GP6 P2RY12 SERPINC1 VWF
9 cell-substrate adhesion GO:0031589 9.4 ITGB3 VWF
10 smooth muscle cell migration GO:0014909 9.32 ITGB3 PLAT
11 blood coagulation GO:0007596 9.23 F3 GP1BA GP6 ITGB3 P2RY12 PLAT

Molecular functions related to Coronary Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.02 F3 ITGB3 SERPINC1 SERPINE1 VWF

Sources for Coronary Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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