MCID: CRN017
MIFTS: 57

Coronary Thrombosis malady

Blood diseases category

Summaries for Coronary Thrombosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Coronary thrombosis is the formation of a blood clot inside a blood vessel of the heart. This blood clot... more...

MalaCards: Coronary Thrombosis, also known as coronary artery thrombosis, is related to myocardial infarction and acute myocardial infarction. An important gene associated with Coronary Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and GP1b-IX-V activation signalling. The drugs heparin and heparin sodium and the compounds integrilin and reviparin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related mouse phenotypes are vision/eye and integument.

Aliases & Classifications for Coronary Thrombosis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

coronary thrombosis 8 44 60
coronary artery thrombosis 8


External Ids:

Disease Ontology8 DOID:11847
MeSH34 D003328

Related Diseases for Coronary Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Coronary Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.3F3, VWF, P2RY12, GP6, GP1BA, PLAT
2acute myocardial infarction31.0FGA, F3, VWF, PLAT, SLC6A4, SERPINE1
3atherosclerosis30.5ITGB3, FGA, F3, VWF, P2RY12, PLAT
4thrombocytosis30.5FGA, F3, VWF, GP1BA, SERPINC1
5coronary artery disease30.5SERPINE1, PLAT, GP1BA, GP6, P2RY12, VWF
6ischemia30.4FGA, PLAT
7purpura30.3SERPINC1
8antiphospholipid syndrome30.3F3, F5, VWF, PLAT, SERPINC1
9thrombocytopenia30.2ITGB3, F5, POU2F3, FGA, F3, VWF
10lupus erythematosus30.1SERPINC1, F3, F5
11pulmonary embolism30.1F5, FGA, F3, PLAT, SERPINC1
12diabetes mellitus30.1FGA, VWF, GP1BA, PLAT, SERPINE1, SERPINC1
13antithrombin iii deficiency29.9SERPINC1, F5
14hyperglycemia29.9FGA, SERPINE1, SERPINF1
15protein c deficiency29.9F5, SERPINE1, SERPINC1
16hypertension29.9F5, PLAT, SLC6A4, SERPINE1
17protein s deficiency29.9F5, FGA, F3, SERPINE1, SERPINC1
18disseminated intravascular coagulation29.9SERPINC1, SERPINE1, F5, FGA, F3, PLAT
19thrombophilia29.9F5, FGA, F3, VWF, PLAT, SERPINE1
20vascular disease29.9FGA, F3, VWF, P2RY12, GP1BA, PLAT
21coronary restenosis10.2
22kawasaki disease10.1
23tuberculosis10.1
24systemic lupus erythematosus10.1
25eclampsia10.0SERPINC1
26polycythemia vera10.0ITGB3
27polycythemia10.0ITGB3
28central retinal artery occlusion10.0PLAT
29intermittent claudication10.0VWF
30polycystic ovary syndrome10.0SERPINE1
31age related macular degeneration10.0PLAT
32obesity10.0SERPINE1
33hemolytic-uremic syndrome10.0VWF
34angiodysplasia10.0VWF
35blindness10.0SERPINF1
36uremia10.0VWF
37arteriosclerosis10.0SERPINE1
38asthma10.0ITGB3
39osteosarcoma10.0SERPINF1
40sneddon syndrome10.0SERPINC1
41hypothyroidism10.0VWF
42proteinuria10.0FGA
43proliferative diabetic retinopathy10.0SERPINF1
44pancreatic cancer10.0PTGS2
45afibrinogenemia10.0FGA
46pneumonia10.0FGA
47oral cancer10.0PTGS2
48arthritis10.0PTGS2
49dilated cardiomyopathy10.0FGA
50cataract10.0SERPINF1

Graphical network of the top 20 diseases related to Coronary Thrombosis:



Diseases related to coronary thrombosis

Clinical Features for Coronary Thrombosis

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Drugs & Therapeutics for Coronary Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Coronary Thrombosis

Drug clinical trials:

Search ClinicalTrials for Coronary Thrombosis

Search NIH Clinical Center for Coronary Thrombosis

Search CenterWatch for Coronary Thrombosis

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Coronary Thrombosis

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Anatomical Context for Coronary Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Coronary Thrombosis:

32
Heart, Lung, Testes, Brain, Liver, Adrenal gland, Endothelial

Animal Models for Coronary Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Coronary Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.7ITGB3, PLAT, SERPINF1
2MP:00107718.8FGA, SLC6A4, PTGS2
3MP:00053858.0ITGB3, FGA, F3, SLC6A4, PTGS2, SERPINF1
4MP:00053817.8ITGB3, FGA, VWF, PLAT, PTGS2, SERPINF1
5MP:00053707.7ITGB3, F5, FGA, PTGS2, SERPINE1, SERPINC1
6MP:00053877.6FGA, F3, VWF, PLAT, PTGS2, SERPINE1
7MP:00053976.7ITGB3, FGA, F3, VWF, P2RY12, GP6
8MP:00036316.7F5, FGA, F3, VWF, PLAT, SLC6A4
9MP:00107686.1ITGB3, F5, POU2F3, FGA, F3, VWF
10MP:00053765.6SERPINC1, ITGB3, F5, FGA, F3, VWF

Publications for Coronary Thrombosis

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50PubMed
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Articles related to Coronary Thrombosis:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Diastolic timed Vibro-Percussion at 50 Hz delivered across a chest wall sized meat barrier enhances clot dissolution and remotely administered Streptokinase effectiveness in an in-vitro model of acute coronary thrombosis. (23146079)
2012
2
Right coronary thrombosis in patient supported by Jarvik 2000 left ventricular assist device. (21071239)
2011
3
Usefulness of cardio MRI on thrombosis of coronary aneurysm as an infrequent cause of ST-elevation coronary syndrome. (19278742)
2010
4
Study on the changes of thrombosis-associated factors in patients with coronary heart disease of turbidity-phlegm blocking syndrome. (19802536)
2009
5
The success of clopidogrel treatment for recurrent coronary thrombosis in a patient with aortic and mitral valve replacement. (18160612)
2008
6
Portal vein thrombosis associated with coronary artery bypass surgery. (18212699)
2008
7
An unpleasant surprise in the setting of primary percutaneous coronary intervention: diffuse and severe vessel ectasia with acute thrombosis of the distal right coronary artery in a patient with acute inferior myocardial infarction. (15902937)
2005
8
Recurrent coronary thrombosis, factor V Leiden, primary antiphospholipid syndrome and HIV]. (15469799)
2004
9
Multivessel coronary thrombosis secondary to cocaine use successfully treated with multivessel primary angioplasty. (15204172)
2004
10
Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease. (14514574)
2003
11
Images in cardiovascular medicine. Coronary thrombosis and myocardial bridging. (11772888)
2002
12
An intraoperative coronary artery bypass graft thrombosis in a patient with protein S deficiency. (11748542)
2001
13
Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries. (11502709)
2001
14
Multivessel coronary thrombosis, acute myocardial infarction, and no reflow in a patient with essential thrombocythaemia. (10814644)
2000
15
Antiplatelet medications and their indications in preventing and treating coronary thrombosis. (11127934)
2000
16
Plasma apolipoprotein B levels predict platelet-dependent thrombosis in patients with coronary artery disease. (10754344)
1999
17
Modifiable risk factors for vascular access site complications in the IMPACT II Trial of angioplasty with versus without eptifibatide. Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis. (9626829)
1998
18
Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation. (9860792)
1998
19
Increased plasminogen activator inhibitor type 1 in coronary artery atherectomy specimens from type 2 diabetic compared with nondiabetic patients: a potential factor predisposing to thrombosis and its persistence. (9631870)
1998
20
Role of activation-dependent platelet membrane glycoproteins in development of subacute occlusive coronary stent thrombosis. (9237020)
1997
21
DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs. (9226103)
1997
22
The acute coronary ischemic syndromes--the central role of thrombosis. (9191478)
1996
23
Myocardial release of endothelin (ET) and enhanced ET(A) receptor-mediated coronary vasoconstriction after coronary thrombosis and thrombolysis in pigs. (8637192)
1995
24
Intraoperative coronary thrombosis: can protamine be incriminated? (7515703)
1994
25
Coronary vasospasm, multiple coronary thrombosis, unstable angina and essential thrombocytosis. (8282442)
1993
26
Coronary spasm as a cause of coronary thrombosis and myocardial infarction. (8301848)
1993
27
Modelling coronary thrombosis from nonanticoagulated human blood in vitro. (2341366)
1990
28
Mediation of reocclusion by thromboxane A2 and serotonin after thrombolysis with tissue-type plasminogen activator in a canine preparation of coronary thrombosis. (3124975)
1988
29
Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty. (2954724)
1987
30
Tissue-type plasminogen activator for acute coronary thrombosis. (3119965)
1987
31
Experimental coronary artery thrombosis in the absence of thromboxane A2 synthesis: evidence for alternate pathways for coronary thrombosis. (2580139)
1985
32
Serotonin blockade during experimental coronary thrombosis. (420072)
1979
33
Nonobstructive coronary thrombosis in sudden cardiac death. (677036)
1978
34
The relationship between coronary artery lesions and myocardial infarcts: ulceration of atherosclerotic plaques precipitating coronary thrombosis. (842443)
1977
35
Effect of experimental coronary thrombosis upon platelet kinetics. (4773372)
1973
36
Coronary thrombosis. (5495163)
1970
37
The consequences of coronary thrombosis. (6079335)
1967
38
The effect of psycho-social factors on the prognosis of coronary thrombosis. (5957598)
1966
39
Coronary thrombosis and myocardial infarction. (5827602)
1965
40
FIBRINOLYTIC THERAPY OF CORONARY THROMBOSIS. (14159476)
1964
41
FIBRINOLYSIN AND ITS RELATION TO THE MANAGEMENT OF CORONARY THROMBOSIS. (14085140)
1963
42
Experimental coronary thrombosis produced by introduction of a stainless steel wire. (13766355)
1961
43
Symmetrical Gangrene Associated with Coronary Thrombosis. (20326294)
1960
44
Coronary thrombosis and myocardial infarction in a 4 1/2-year-old boy. (13553613)
1958
45
Coronary thrombosis in general practice. (13465575)
1957
46
Comments on the armchair treatment of coronary thrombosis. (13368212)
1956
47
Contribution on cutaneous temperature over the heart under normal conditions and after coronary thrombosis]. (13257156)
1955
48
The diagnosis and treatment of impending coronary thrombosis. (13261155)
1955
49
Personal observations on the evolution of an attack of coronary thrombosis. (13084937)
1953
50
Does exertion precipitate coronary thrombosis? (13023275)
1953

Genetic Variations for Coronary Thrombosis

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Expression for genes affiliated with Coronary Thrombosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Coronary Thrombosis

Search GEO for disease gene expression data for Coronary Thrombosis.

Pathways for genes affiliated with Coronary Thrombosis

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB, 29KEGG, 52R&D Systems
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Pathways related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLAT, SERPINE1
29.8VWF, GP1BA
3
Hide members
9.5VWF, FGA, ITGB3
4
Cell adhesion ECM remodeling
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9.5SERPINE1, PLAT, FGA
59.4VWF, GP6, GP1BA
6
Hide members
9.1GP1BA, VWF, FGA, ITGB3
79.1SERPINE1, PTGS2, PLAT
8
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9.1SERPINE1, PTGS2, F3
9
Hide members
8.9F5, FGA, F3, SERPINC1
108.8ITGB3, FGA, VWF, P2RY12, GP6
11
Hide members
8.6ITGB3, F5, FGA, VWF, SERPINE1
12
Hide members
8.4ITGB3, FGA, VWF, GP6, GP1BA, SERPINE1
13
Hide members
8.3GP1BA, GP6, P2RY12, VWF, F3, FGA
14
Hide members
8.3ITGB3, F5, FGA, F3, SERPINE1, SERPINC1
15
Hide members
8.1F5, FGA, F3, VWF, PLAT, SERPINE1
16
Hide members
7.3F5, FGA, F3, VWF, GP6, GP1BA

Compounds for genes affiliated with Coronary Thrombosis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1integrilin4410.0SERPINC1, PLAT, VWF
2reviparin4410.0F3, PLAT, SERPINC1
3aspartate4410.0SLC6A4
4warfarin44 49 11 2412.9FGA, SERPINC1, VWF
5efegatran449.8F3, PLAT, SERPINC1
6epsilon aminocaproic acid449.6SERPINE1, SERPINC1, F3, PLAT
7desirudin449.6F3, PLAT, FGA
8fucoidan449.6PLAT, F3, SERPINE1, SERPINC1
9tranexamic acid44 1110.5SERPINC1, VWF, SERPINE1, PLAT, F3
10spectrozyme449.4PLAT, F3, F5, SERPINC1
11inogatran449.4SERPINC1, F3, F5
12fondaparinux449.4SERPINC1, F5, F3, PLAT
13protamine sulfate449.4F5, F3, PLAT, SERPINC1
14tirofiban44 1110.3F3, P2RY12, ITGB3, SERPINC1, VWF, PLAT
15clopidogrel49 44 11 2412.3SERPINC1, ITGB3, F3, VWF, P2RY12, PLAT
16batroxobin449.2PLAT, FGA, SERPINE1, F5
17serine449.2FGA, GP1BA, SLC6A4, SERPINF1
18hirugen449.2SERPINC1, FGA, F5
19raloxifene44 28 49 1112.1SERPINC1, SERPINE1, SLC6A4, F5
20levonorgestrel44 59 28 1112.1SERPINC1, PLAT, F3, F5
21dermatan sulfate449.1SERPINC1, PLAT, VWF, F3, F5
22ppack449.1F3, VWF, P2RY12, PLAT, SERPINC1, FGA
23ticlopidine44 1110.1F3, FGA, VWF, P2RY12, PLAT, SERPINC1
24ancrod449.0SERPINE1, SERPINC1, PLAT, FGA, F5
25convulxin449.0GP6, GP1BA, F5, P2RY12
26ecarin449.0F3, SERPINC1, F5
27bivalirudin44 1110.0FGA, F3, SERPINC1, F5, PLAT
28argatroban44 1110.0PLAT, SERPINC1, F3, FGA, F5
29abciximab44 119.9SERPINC1, PLAT, GP1BA, ITGB3, F3, VWF
30heparin44 28 11 2411.9SERPINF1, GP1BA, P2RY12, FGA, POU2F3
31adp44 28 2410.9P2RY12, PLAT, FGA, SLC6A4, GP6
32homocysteine44 249.9VWF, PLAT, SERPINE1, SERPINC1, F3, F5
33creatinine448.8F5, FGA, GP6, F3, P2RY12
34protamine448.7SERPINC1, SERPINE1, PLAT, F5, FGA, F3
35pge1448.6P2RY12, VWF, PLAT, SERPINE1, FGA, F5
36kininogen448.6F5, F3, VWF, GP1BA, PLAT, SERPINE1
37phosphatidylserine44 28 1110.5F5, ITGB3, F3, VWF, GP6, GP1BA
38simvastatin44 49 59 28 11 2413.5VWF, F5, SERPINE1, SLC6A4, F3, PLAT
39aprotinin44 119.5F5, FGA, F3, VWF, PLAT, SERPINE1
40thromboxane44 249.3VWF, FGA, P2RY12, GP6, PLAT, PTGS2
41thromboxane a244 249.3GP6, FGA, PLAT, VWF, P2RY12, PTGS2
42ristocetin448.2ITGB3, F5, F3, VWF, GP1BA, PLAT
43hirudin448.1GP1BA, PLAT, SERPINE1, SERPINC1, F3, VWF
44desmopressin44 59 28 1110.8PLAT, PTGS2, SERPINE1, SERPINC1, GP1BA, VWF
45epinephrine44 11 249.6FGA, F3, VWF, P2RY12, GP6, GP1BA
46vegf447.6ITGB3, F3, VWF, SERPINF1, SERPINC1, PTGS2
47alanine447.4ITGB3, F5, F3, GP1BA, SLC6A4, GP6
48prostacyclin447.3SERPINC1, SERPINE1, PTGS2, F5, FGA, F3
49fibrinogen447.2VWF, F3, FGA, F5, ITGB3, P2RY12
50aspirin44 49 28 249.3F3, FGA, F5, ITGB3, VWF, SERPINC1

GO Terms for genes affiliated with Coronary Thrombosis

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16Gene Ontology
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Cellular components related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:0310919.8VWF, FGA
2extracellular matrixGO:0310129.1F3, VWF, PLAT, SERPINE1, SERPINF1
3platelet alpha granule lumenGO:0310939.0SERPINE1, VWF, FGA, F5
4extracellular spaceGO:0056158.0F5, FGA, F3, PLAT, SERPINE1, SERPINC1
5extracellular regionGO:0055767.7F5, FGA, VWF, PLAT, SERPINE1, SERPINC1
6plasma membraneGO:0058866.6ITGB3, F5, FGA, F3, P2RY12, GP6

Biological processes related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:01490910.1PLAT, ITGB3
2hemostasisGO:0075999.9P2RY12, VWF
3platelet aggregationGO:0705279.8P2RY12, ITGB3
4fibrinolysisGO:0427309.7SERPINE1, PLAT, GP1BA
5negative regulation of endopeptidase activityGO:0109519.7SERPINE1, SERPINC1, SERPINF1
6blood coagulation, intrinsic pathwayGO:0075979.5VWF, GP1BA
7negative regulation of synaptic transmission, dopaminergicGO:0322279.3SLC6A4, PTGS2
8cell adhesionGO:0071559.0GP1BA, VWF, F5, ITGB3
9platelet degranulationGO:0025768.8ITGB3, F5, FGA, VWF, SERPINE1
10platelet activationGO:0301687.7ITGB3, F5, FGA, VWF, P2RY12, GP6
11blood coagulationGO:0075967.0SERPINC1, ITGB3, F5, FGA, F3, VWF

Molecular functions related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.6SERPINF1, SERPINC1, SERPINE1
2protease bindingGO:0020209.3SERPINC1, SERPINE1, VWF, F3
3protein bindingGO:0055155.7F3, FGA, POU2F3, F5, ITGB3, VWF

Products for genes affiliated with Coronary Thrombosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coronary Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet