MCID: CRN017
MIFTS: 55

Coronary Thrombosis malady

Blood category

Summaries for Coronary Thrombosis

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Coronary thrombosis is a form of thrombosis affecting the coronary circulation. It is associated with... more...

MalaCards: Coronary Thrombosis, also known as coronary artery thrombosis, is related to acute myocardial infarction and atherosclerosis. An important gene associated with Coronary Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and GP1b-IX-V activation signalling. The drugs heparin and heparin sodium and the compounds integrilin and reviparin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related mouse phenotypes are vision/eye and integument.

Aliases & Classifications for Coronary Thrombosis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

coronary thrombosis 8 45 61
coronary artery thrombosis 8


External Ids:

Disease Ontology8 DOID:11847
MeSH35 D003328

Related Diseases for Coronary Thrombosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Coronary Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction31.0FGA, F3, VWF, PLAT, SLC6A4, SERPINE1
2atherosclerosis30.6ITGB3, FGA, F3, VWF, P2RY12, PLAT
3thrombocytosis30.5FGA, F3, VWF, GP1BA, SERPINC1
4coronary artery disease,30.5SERPINE1, PLAT, GP1BA, GP6, P2RY12, VWF
5antiphospholipid syndrome30.3F3, F5, VWF, PLAT, SERPINC1
6thrombocytopenia30.3ITGB3, F5, POU2F3, FGA, F3, VWF
7protein c deficiency30.2F5, SERPINE1, SERPINC1
8venous thrombosis30.1SERPINC1, SERPINE1, PLAT, VWF, F3, FGA
9septic shock29.9F5, FGA, F3, SERPINE1, SERPINC1
10thrombophilia29.9F5, FGA, F3, VWF, PLAT, SERPINE1
11coronary heart disease29.9SERPINC1, SERPINE1, PLAT, ITGB3, FGA, VWF
12thromboembolism29.9F5, FGA, F3, VWF, GP6, PLAT
13vascular disease29.9FGA, F3, VWF, P2RY12, GP1BA, PLAT
14coronary restenosis10.2
15heparin-induced thrombocytopenia10.2
16kawasaki disease10.1
17tuberculosis10.1
18essential thrombocythemia10.1
19systemic lupus erythematosus10.1
20catastrophic antiphospholipid syndrome10.1
21coronary artery aneurysm10.1
22retroperitoneal fibrosis10.1
23serotonin syndrome10.1
24angina pectoris10.0
25burns10.0
26cardiac tamponade10.0
27acute pancreatitis10.0
28coronary aneurysm10.0
29thrombotic thrombocytopenic purpura10.0
30subacute bacterial endocarditis10.0
31young syndrome10.0
32cardiac rupture10.0
33warfarin syndrome10.0
34hypereosinophilic syndrome10.0
35protein r deficiency10.0
36single ventricular heart10.0
37rheumatic disease10.0
38cardiogenic shock10.0
39purpura10.0SERPINC1
40eclampsia10.0SERPINC1
41polycythemia vera10.0ITGB3
42polycythemia10.0ITGB3
43central retinal artery occlusion10.0PLAT
44intermittent claudication10.0VWF
45polycystic ovary syndrome10.0SERPINE1
46age related macular degeneration10.0PLAT
47obesity10.0SERPINE1
48hemolytic-uremic syndrome10.0VWF
49angiodysplasia10.0VWF
50blindness10.0SERPINF1

Graphical network of the top 20 diseases related to Coronary Thrombosis:



Diseases related to coronary thrombosis

Clinical Features for Coronary Thrombosis

Drugs & Therapeutics for Coronary Thrombosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Coronary Thrombosis

Drug clinical trials:

Search ClinicalTrials for Coronary Thrombosis

Search NIH Clinical Center for Coronary Thrombosis

Search CenterWatch for Coronary Thrombosis

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Genetic Tests for Coronary Thrombosis

Anatomical Context for Coronary Thrombosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Coronary Thrombosis:

33
Brain, Heart, Liver, Lung, Adrenal gland, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung

Animal Models for Coronary Thrombosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Coronary Thrombosis

Sources:
51PubMed
See all sources

Articles related to Coronary Thrombosis:

(show top 50)    (show all 615)
idTitleAuthorsYear
1
Extensive coronary aneurysms with thrombosis in resistant Kawasaki disease. (22427313)
2013
2
Comparison of long-term outcome after percutaneous coronary intervention for stent thrombosis between early, late, and very late stent thrombosis. (24189504)
2013
3
Multivessel coronary thrombosis in a patient with idiopathic thrombocytopenic purpura. (23304046)
2012
4
Coronary thrombosis as the first complication of antiphospholipid syndrome. (22735914)
2012
5
Role of platelet glycoprotein receptor IIIa PI(A2) and traditional risk factors in the etiology of coronary thrombosis. (21816456)
2011
6
Coronary thrombosis and myocardial infarction as the initial manifestation of protein C deficiency in a 20-year-old man. (21481934)
2011
7
Contrast staining outside the sirolimus-eluting stent leading to coronary aneurysm formation: a case of very late stent thrombosis associated with hypersensitivity reaction. (21325194)
2011
8
Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model. (20694285)
2010
9
Clinically relevant concentrations of dopamine do not amplify agonist-induced human platelet Ca2+ mobilization or GP IIb IIIa activation and do not accelerate acute coronary thrombosis in dogs. (19247190)
2009
10
Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention. (19193675)
2009
11
The success of warfarin treatment for coronary thrombosis in a young patient with acute coronary syndrome. (18160583)
2009
12
Endovascular management of early portal vein thrombosis caused by coronary vein steal after liver transplantation and its outcome. (18460001)
2008
13
Late coronary thrombosis secondary to implantation of paclitaxel-eluting stent without restenosis of conventional stents. (17589614)
2007
14
Late coronary thrombosis in a sirolimus-eluting stent due to the lack of neointimal coverage. (16243922)
2006
15
Evaluation of fibronectin, vitronectin, and leptin levels in coronary artery disease: impacts on thrombosis and thrombolysis. (15678274)
2005
16
Improved procedural results in coronary thrombosis are obtained with delayed percutaneous coronary interventions. (14760194)
2004
17
Early experience with a helical coronary thrombectomy device in patients with acute coronary thrombosis. (11997421)
2002
18
The prothrombin 20210A allele and the factor V Leiden are associated with venous thrombosis but not with early coronary artery disease. (10070834)
1999
19
Cold pressure test producing coronary spasm, coronary thrombosis and myocardial infarction in a patient with IgM antibodies against Coxsackie B virus. (10844390)
1999
20
Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction. (10455073)
1999
21
Clinical outcomes after detection of elevated cardiac enzymes in patients undergoing percutaneous intervention. IMPACT-II Investigators. Integrilin (eptifibatide) to Minimize Platelet Aggregation and Coronary Thrombosis-II. (9935014)
1999
22
Comparative effects of anti-platelet agents as adjuncts to tissue plasminogen activator in a dog model of occlusive coronary thrombosis. (8032650)
1994
23
Effects of Y-20811, a thromboxane A2 synthetase inhibitor, on experimentally induced coronary thrombosis in anesthetized dogs. (1521557)
1992
24
Coronary thrombosis: pathogenesis and clinical manifestations. (1892065)
1991
25
Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis. (1689620)
1990
26
Simultaneous administration of thromboxane A2- and serotonin S2-receptor antagonists markedly enhances thrombolysis and prevents or delays reocclusion after tissue-type plasminogen activator in a canine model of coronary thrombosis. (2494005)
1989
27
Therapeutic trials in coronary thrombosis should measure left ventricular function as primary end-point of treatment. (2891942)
1988
28
Tissue plasminogen activator for coronary thrombosis. (3126630)
1988
29
Coronary thrombosis and subsequent lysis after a marathon. (6501731)
1984
30
A new model for coronary thrombosis in the pig: preliminary results with thrombolysis. (6225645)
1983
31
Personal reflections on the development of thrombolytic therapy and its application to acute coronary thrombosis. (6459018)
1981
32
Relationship Between Coronary Thrombosis and Myocardial Infarction. (4680899)
1972
33
Anticoagulant treatment of acute coronary thrombosis. (4185116)
1969
34
Assessment of short-anticoagulant administration after cardiac infarction. Report of the Working Party on Anticoagulant Therapy in Coronary Thrombosis to the Medical Research Council. (4885307)
1969
35
A two-year study of intensive care unit treatment of acute coronary thrombosis. (5173851)
1965
36
EMOTIONAL REACTIONS TO INITIAL ATTACKS OF CORONARY THROMBOSIS. (14132354)
1964
37
ACUTE CORONARY THROMBOSIS AND CARDIAC INFARCTION IN ALBINO RATS. (14232339)
1964
38
Experimental myocardial infarction. Induction of coronary thrombosis in the intact closed-chest dog. (14496296)
1961
39
Fibrinolytic treatment of coronary thrombosis. A pilot study. (13722386)
1961
40
The influence of meteorological changes on coronary thrombosis. (13681478)
1960
41
Emergency management of coronary thrombosis. (13347081)
1956
42
Treatment of coronary thrombosis with myocardial infarction. (13263101)
1955
43
Coronary thrombosis: treatment. (14367831)
1955
44
Smoking and Coronary Thrombosis. (20788387)
1955
45
Experiences with aspirin (Acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis. (13013156)
1953
46
Long term dicumarol therapy in thromboembolic conditions, especially coronary thrombosis. (13091736)
1953
47
Management of convalescence and later life after coronary thrombosis. (13110362)
1953
48
Experience with anticoagulant therapy in the treatment of coronary thrombosis. (13042714)
1953
49
The relationship of chronic peptic ulcer to coronary thrombosis. (14952509)
1952
50
Coronary arteriosclerosis, with recent thrombosis of left circumflex artery. (18907107)
1948

Genetic Variations for Coronary Thrombosis

Expression for genes affiliated with Coronary Thrombosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Coronary Thrombosis

Search GEO for disease gene expression data for Coronary Thrombosis.

Pathways for genes affiliated with Coronary Thrombosis

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 50PharmGKB, 30KEGG, 53R&D Systems
See all sources

Pathways related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLAT, SERPINE1
29.8VWF, GP1BA
3
Hide members
9.5VWF, FGA, ITGB3
4
Cell adhesion ECM remodeling
Hide members
9.5SERPINE1, PLAT, FGA
59.4VWF, GP6, GP1BA
6
Hide members
9.1GP1BA, VWF, FGA, ITGB3
79.1SERPINE1, PTGS2, PLAT
8
Hide members
9.1SERPINE1, PTGS2, F3
9
Hide members
8.9F5, FGA, F3, SERPINC1
108.8ITGB3, FGA, VWF, P2RY12, GP6
11
Hide members
8.6ITGB3, F5, FGA, VWF, SERPINE1
12
Hide members
8.4ITGB3, FGA, VWF, GP6, GP1BA, SERPINE1
13
Hide members
8.3GP1BA, GP6, P2RY12, VWF, F3, FGA
14
Hide members
8.3ITGB3, F5, FGA, F3, SERPINE1, SERPINC1
15
Hide members
8.1F5, FGA, F3, VWF, PLAT, SERPINE1
16
Hide members
7.3F5, FGA, F3, VWF, GP6, GP1BA

Compounds for genes affiliated with Coronary Thrombosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1integrilin4510.0SERPINC1, PLAT, VWF
2reviparin4510.0F3, PLAT, SERPINC1
3aspartate4510.0SLC6A4
4warfarin45 50 11 2412.9FGA, SERPINC1, VWF
5efegatran459.8F3, PLAT, SERPINC1
6epsilon aminocaproic acid459.6SERPINE1, SERPINC1, F3, PLAT
7desirudin459.6F3, PLAT, FGA
8fucoidan459.6PLAT, F3, SERPINE1, SERPINC1
9tranexamic acid45 1110.5SERPINC1, VWF, SERPINE1, PLAT, F3
10spectrozyme459.4PLAT, F3, F5, SERPINC1
11inogatran459.4SERPINC1, F3, F5
12fondaparinux459.4SERPINC1, F5, F3, PLAT
13protamine sulfate459.4F5, F3, PLAT, SERPINC1
14tirofiban45 1110.3F3, P2RY12, ITGB3, SERPINC1, VWF, PLAT
15clopidogrel50 45 11 2412.3SERPINC1, ITGB3, F3, VWF, P2RY12, PLAT
16batroxobin459.2PLAT, FGA, SERPINE1, F5
17serine459.2FGA, GP1BA, SLC6A4, SERPINF1
18hirugen459.2SERPINC1, FGA, F5
19raloxifene45 29 50 1112.1SERPINC1, SERPINE1, SLC6A4, F5
20levonorgestrel45 60 29 1112.1SERPINC1, PLAT, F3, F5
21dermatan sulfate459.1SERPINC1, PLAT, VWF, F3, F5
22ppack459.1F3, VWF, P2RY12, PLAT, SERPINC1, FGA
23ticlopidine45 1110.1F3, FGA, VWF, P2RY12, PLAT, SERPINC1
24ancrod459.0SERPINE1, SERPINC1, PLAT, FGA, F5
25convulxin459.0GP6, GP1BA, F5, P2RY12
26ecarin459.0F3, SERPINC1, F5
27bivalirudin45 1110.0FGA, F3, SERPINC1, F5, PLAT
28argatroban45 1110.0PLAT, SERPINC1, F3, FGA, F5
29abciximab45 119.9SERPINC1, PLAT, GP1BA, ITGB3, F3, VWF
30heparin45 29 11 2411.9SERPINF1, GP1BA, P2RY12, FGA, POU2F3
31adp45 29 2410.9P2RY12, PLAT, FGA, SLC6A4, GP6
32homocysteine45 249.9VWF, PLAT, SERPINE1, SERPINC1, F3, F5
33creatinine458.8F5, FGA, GP6, F3, P2RY12
34protamine458.7SERPINC1, SERPINE1, PLAT, F5, FGA, F3
35pge1458.6P2RY12, VWF, PLAT, SERPINE1, FGA, F5
36kininogen458.6F5, F3, VWF, GP1BA, PLAT, SERPINE1
37phosphatidylserine45 29 1110.5F5, ITGB3, F3, VWF, GP6, GP1BA
38simvastatin45 50 60 29 11 2413.5VWF, F5, SERPINE1, SLC6A4, F3, PLAT
39aprotinin45 119.5F5, FGA, F3, VWF, PLAT, SERPINE1
40thromboxane45 249.3VWF, FGA, P2RY12, GP6, PLAT, PTGS2
41thromboxane a245 249.3GP6, FGA, PLAT, VWF, P2RY12, PTGS2
42ristocetin458.2ITGB3, F5, F3, VWF, GP1BA, PLAT
43hirudin458.1GP1BA, PLAT, SERPINE1, SERPINC1, F3, VWF
44desmopressin45 60 29 1110.8PLAT, PTGS2, SERPINE1, SERPINC1, GP1BA, VWF
45epinephrine45 11 249.6FGA, F3, VWF, P2RY12, GP6, GP1BA
46vegf457.6ITGB3, F3, VWF, SERPINF1, SERPINC1, PTGS2
47alanine457.4ITGB3, F5, F3, GP1BA, SLC6A4, GP6
48prostacyclin457.3SERPINC1, SERPINE1, PTGS2, F5, FGA, F3
49fibrinogen457.2VWF, F3, FGA, F5, ITGB3, P2RY12
50aspirin45 50 29 249.3F3, FGA, F5, ITGB3, VWF, SERPINC1

GO Terms for genes affiliated with Coronary Thrombosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:0310919.8VWF, FGA
2extracellular matrixGO:0310129.1F3, VWF, PLAT, SERPINE1, SERPINF1
3platelet alpha granule lumenGO:0310939.0SERPINE1, VWF, FGA, F5
4extracellular spaceGO:0056158.0F5, FGA, F3, PLAT, SERPINE1, SERPINC1
5extracellular regionGO:0055767.7F5, FGA, VWF, PLAT, SERPINE1, SERPINC1
6plasma membraneGO:0058866.6ITGB3, F5, FGA, F3, P2RY12, GP6

Biological processes related to Coronary Thrombosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:01490910.1PLAT, ITGB3
2hemostasisGO:0075999.9P2RY12, VWF
3platelet aggregationGO:0705279.8P2RY12, ITGB3
4fibrinolysisGO:0427309.7SERPINE1, PLAT, GP1BA
5negative regulation of endopeptidase activityGO:0109519.7SERPINE1, SERPINC1, SERPINF1
6blood coagulation, intrinsic pathwayGO:0075979.5VWF, GP1BA
7negative regulation of synaptic transmission, dopaminergicGO:0322279.3SLC6A4, PTGS2
8cell adhesionGO:0071559.0GP1BA, VWF, F5, ITGB3
9platelet degranulationGO:0025768.8ITGB3, F5, FGA, VWF, SERPINE1
10platelet activationGO:0301687.7ITGB3, F5, FGA, VWF, P2RY12, GP6
11blood coagulationGO:0075967.0SERPINC1, ITGB3, F5, FGA, F3, VWF

Molecular functions related to Coronary Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.6SERPINF1, SERPINC1, SERPINE1
2protease bindingGO:0020209.3SERPINC1, SERPINE1, VWF, F3
3protein bindingGO:0055155.7F3, FGA, POU2F3, F5, ITGB3, VWF

Products for genes affiliated with Coronary Thrombosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Coronary Thrombosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet