MCID: CRT012
MIFTS: 45

Cortical Blindness malady

Summaries for Cortical Blindness

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cortical blindness is the total or partial loss of vision in a normal-appearing eye caused by damage to... more...

MalaCards: Cortical Blindness, also known as blindness, cortical, is related to dementia and melas syndrome. An important gene associated with Cortical Blindness is MT-ND4 (mitochondrially encoded NADH dehydrogenase 4), and among its related pathways are Histidine metabolism and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds isoleucine and aprosulate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are normal and nervous system.

Aliases & Classifications for Cortical Blindness

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

cortical blindness 8 10
blindness, cortical 60


External Ids:

Disease Ontology8 DOID:11831
ICD9CM27 377.75
SNOMED-CT56 68574006
MeSH34 D019575

Related Diseases for Cortical Blindness

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cortical Blindness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.2TIMM8A, IFNA10, PRNP
2melas syndrome30.1MT-ND6
3neuropathy29.9POLG
4cerebritis10.6
5eclampsia10.5
6meningitis10.4
7glomerulonephritis10.3
8anosognosia10.2
9hypoglycemia10.2
10cervicitis10.2
11endocarditis10.2
12influenza10.2
13pre-eclampsia10.2
14hellp syndrome10.2
15status epilepticus10.2
16subacute sclerosing panencephalitis10.2
17acute intermittent porphyria10.2
18acute porphyria10.2
19hepatic encephalopathy10.2
20hepatitis10.2
21hypertension10.2
22porphyria10.2
23cortical blindness - intellectual deficit - polydactyly10.2
24intracranial embolism10.1
25quadriplegia10.1
26sagittal sinus thrombosis10.1
27intracranial aneurysm10.1
28progressive multifocal leukoencephalopathy10.1
29agnosia10.1
30asthma10.1
31bacterial meningitis10.1
32cerebellar ataxia10.1
33encephalitis10.1
34hemiplegia10.1
35hydrocephalus10.1
36infective endocarditis10.1
37purpura10.1
38retinitis10.1
39sarcoidosis10.1
40cortical blindness mental retardation polydactyly10.1
41opa3-related 3-methylglutaconic aciduria10.0MT-ND4
42multiple sclerosis10.0ABCD1
43diabetes mellitus10.0MT-ND1
44leukodystrophy10.0ASPA
45blindness10.0MT-ND4, TIMM8A
46leber hereditary optic neuropathy with dystonia10.0MT-ND4, MT-ND6
47deafness-dystonia-optic neuronopathy syndrome10.0TIMM8A, TIMM13
48mitochondrial disorders10.0MT-ND4, MT-ND5
49optic nerve disease10.0MT-ND6, MT-ND4
50hemarthrosis10.0F3

Graphical network of the top 20 diseases related to Cortical Blindness:



Diseases related to cortical blindness

Clinical Features for Cortical Blindness

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Drugs & Therapeutics for Cortical Blindness

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cortical Blindness

Drug clinical trials:

Search ClinicalTrials for Cortical Blindness

Search NIH Clinical Center for Cortical Blindness

Search CenterWatch for Cortical Blindness

Genetic Tests for Cortical Blindness

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Anatomical Context for Cortical Blindness

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32MalaCards
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MalaCards organs/tissues related to Cortical Blindness:

32
Brain, Eye, Cortex, Liver, Occipital lobe, Heart, Testes, Bone marrow, Bone, Kidney, Endothelial, Spinal cord, Prostate, Placenta, Breast, Lung, Skeletal muscle, Amygdala

Animal Models for Cortical Blindness or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cortical Blindness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.5PRNP, F3, ABCD1, F2, ASPA, ALDH7A1
2MP:00036316.6ASPA, ISL2, MT-ND6, PRNP, POLG, F3

Publications for Cortical Blindness

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50PubMed
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Articles related to Cortical Blindness:

(show top 50)    (show all 375)
idTitleAuthorsYear
1
Isolated cortical blindness without simultaneous neurological involvement in progressive multifocal leukoencephalopathy in a patient with human immune deficiency virus infection. (23514446)
2013
2
Cortical plasticity and preserved function in early blindness. (23453908)
2013
3
Reversible cortical blindness and internuclear ophthalmoplegia after neurosurgical operation: case report and review of the literature. (23042139)
2013
4
Post-anesthetic cortical blindness in cats: twenty cases. (22381708)
2012
5
Cortical blindness after contrast-enhanced CT scan in a patient of sarcoidosis - Is it related to posterior reversible encephalopathy syndrome? (22346022)
2011
6
Reversible Cortical Blindness as a Prominent Manifestation of Cerebral Embolism due to Infective Endocarditis. (20811562)
2010
7
Analysis of cyclosporin A-induced reversible cortical blindness by diffusion-weighted magnetic resonance imaging techniques. (20577864)
2010
8
Cortical blindness, transient and otherwise, associated with detachable coil embolization of intracranial aneurysms. (18065506)
2008
9
MR imaging findings of cortical blindness following cerebral angiography: is this entity related to posterior reversible leukoencephalopathy? (15661726)
2005
10
Cortical blindness and acute myocardial infarction following injection of bleeding gastric varices with cyanoacrylate glue. (16189782)
2005
11
Cortical blindness, a rare complication of pre-eclampsia. (16183449)
2005
12
MR findings of cortical blindness following cerebral angiography: is this entity related to posterior reversible leukoencephalopathy? (14970026)
2004
13
Transient bilateral cortical blindness in an adult after an acute episode of asthma exacerbation. (15115270)
2004
14
Diffusion-weighted magnetic resonance imaging and the evaluation of cortical blindness in preeclampsia. (14609710)
2003
15
Spatial and temporal processing in a subject with cortical blindness following occipital surgery. (12757903)
2003
16
MRI findings in a case of transient cortical blindness after cardiac catheterization. (12203927)
2002
17
Cortical blindness: an unusual presentation of eclampsia. (11996448)
2001
18
Cortical blindness: an unusual complication after removal of a ganglioneuroma of the neck. (11417417)
2001
19
A case of Churg-Strauss syndrome presenting with cortical blindness. (10941817)
2000
20
Bilateral cortical blindness after lumbar spine surgery. A case report. (9728383)
1998
21
Cortical blindness due to pregnancy-induced hypertension in the presence of a normal magnetic. (15511806)
1997
22
Cortical blindness following coronary arteriography: a rare but self-cured complication. Two case reports. (8712484)
1996
23
Status epilepticus amauroticus secondary to meningitis as a cause of postpartum cortical blindness. (8956400)
1996
24
Cortical blindness in preeclampsia: diagnostic evaluation by transcranial Doppler and magnetic resonance imaging techniques. (7660773)
1995
25
The McCollough effect reveals orientation discrimination in a case of cortical blindness. (7583104)
1995
26
Transient cortical blindness due to hypertensive encephalopathy. Magnetic resonance imaging correlation. (8501259)
1993
27
Cortical blindness after cardiac catheterization: effect of rechallenge with dye. (8448799)
1993
28
Transient cortical blindness after coronary angiography. (8280526)
1993
29
Cortical blindness and seizures possibly related to cisplatin, vinblastine, and bleomycin treatment of ovarian dysgerminoma. (7683015)
1993
30
Cortical blindness in children: utility of flash VEPs. (1580963)
1992
31
Optokinetic response and adaptation of the vestibulo-ocular reflex (VOR) in a patient with chronic cortical blindness. (1927469)
1991
32
Prognostic value of VEPs in young children with acute onset of cortical blindness. (2059250)
1991
33
Acute glomerulonephritis and cortical blindness in a 24-year-old man. (2498784)
1989
34
Cortical blindness caused by acute general cerebral swelling. (3363476)
1988
35
Cortical blindness after left internal mammary artery to left anterior descending coronary artery graft angiography. (3409312)
1988
36
Cortical blindness. (2896935)
1988
37
Metamorphopsia and permanent cortical blindness after a posterior fossa tumor. (3748356)
1986
38
Training of color and form identification in cortical blindness: a case study. (3729696)
1986
39
Cortical blindness following ictal nystagmus. (3977648)
1985
40
Cortical blindness as the initial symptom in severe preeclampsia. (6650613)
1983
41
Cortical blindness following cardiac arrest. (7184932)
1982
42
Transient cortical blindness in hepatic encephalopathy. (521266)
1979
43
Cortical blindness following hypoxia during cardiac arrest. (665992)
1978
44
Transitory cortical blindness following head injury. (4855241)
1974
45
The aetiology of cortical blindness in Nigeria. (5521690)
1970
46
Cortical blindness and the functions of the non-geniculate fibres of the optic tracts. (5807867)
1969
47
Electrophysiological findings in cortical blindness. Report of a case. (4160394)
1966
48
Cortical blindness in congenital hydrocephalus. (5944739)
1966
49
Cortical blindness. (13525992)
1958
50
Cortical blindness and spastic quadriparesis following apnoea in an asthmatic attack. (13155542)
1954

Genetic Variations for Cortical Blindness

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Expression for genes affiliated with Cortical Blindness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cortical Blindness

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Pathways for genes affiliated with Cortical Blindness

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29KEGG, 53Reactome, 49PharmGKB, 51QIAGEN
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Compounds for genes affiliated with Cortical Blindness

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Cortical Blindness according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1isoleucine4410.0MT-ND6, MT-ND4, PRNP
2aprosulate449.9F3, F2
3napsagatran449.9F3, F2
4brodifacoum449.9F3, F2
5mnpt449.9F3, F2
6hemochron449.9F3, F2
7certoparin449.9F3, F2
8appt449.9F3, F2
9inogatran449.9F2, F3
10heparin sodium449.9F2, F3
11ecarin449.9F3, F2
12dextran 70449.9F3, F2
13spectrozyme449.9F2, F3
14polybrene449.9F2, F3
15s-warfarin449.8F3, F2
16danaparoid449.8F3, F2
17hepaplastin449.8F3, F2
18kaolin449.8F3, F2
19organon449.8F3, F2
20rivaroxaban44 1110.8F3, F2
21ximelagatran44 1110.8F3, F2
22vitamin k144 2410.8F3, F2
23nad28 2410.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, ALDH7A1
24heparinoids449.8F3, F2
25fondaparinux449.8F2, F3
26nadh44 11 2411.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, ALDH7A1
27acenocoumarol44 49 1111.7F3, F2
28bivalirudin44 1110.7F3, F2
29coumarins449.7F3, F2
30methionine449.7PRNP, MT-ND5, MT-ND1, MT-ND6
31phenprocoumon44 49 1111.6F3, F2
32valine449.6PRNP, MT-ND5, MT-ND4, MT-ND1, MT-ND6
33argatroban44 1110.6F3, F2
34hydroxyethyl starch449.6F3, F2
35ppack449.5F2, F3
36tirofiban44 1110.5F2, F3
37tranexamic acid44 1110.4F3, F2
38protamine sulfate449.2F3, F2
39atp44 2810.1MT-ND1, MT-ND4, MT-ND5, PRNP, POLG, ABCD1
40alanine448.6MT-ND6, MT-ND1, MT-ND5, PRNP, POLG, F3

GO Terms for genes affiliated with Cortical Blindness

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16Gene Ontology
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Biological processes related to Cortical Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chaperone-mediated protein transportGO:0723219.3TIMM8A, TIMM13
2sensory perception of soundGO:0076059.2ALDH7A1, SLC26A5, TIMM13

Products for genes affiliated with Cortical Blindness

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Sources for Cortical Blindness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet