MCID: CRT012
MIFTS: 45

Cortical Blindness malady

Summaries for Cortical Blindness

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cortical blindness is the total or partial loss of vision in a normal-appearing eye caused by damage to... more...

MalaCards: Cortical Blindness, also known as blindness, cortical, is related to dementia and melas syndrome. An important gene associated with Cortical Blindness is MT-ND4 (mitochondrially encoded NADH dehydrogenase 4), and among its related pathways are Histidine metabolism and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds isoleucine and aprosulate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are normal and nervous system.

Aliases & Classifications for Cortical Blindness

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

cortical blindness 8 10
blindness, cortical 60


External Ids:

Disease Ontology8 DOID:11831
ICD9CM27 377.75
SNOMED-CT56 68574006
MeSH34 D019575

Related Diseases for Cortical Blindness

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cortical Blindness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.2TIMM8A, IFNA10, PRNP
2melas syndrome30.1MT-ND6
3neuropathy29.9POLG
4cerebritis10.6
5eclampsia10.5
6meningitis10.4
7glomerulonephritis10.3
8anosognosia10.2
9hypoglycemia10.2
10cervicitis10.2
11endocarditis10.2
12influenza10.2
13pre-eclampsia10.2
14hellp syndrome10.2
15status epilepticus10.2
16subacute sclerosing panencephalitis10.2
17acute intermittent porphyria10.2
18acute porphyria10.2
19hepatic encephalopathy10.2
20hepatitis10.2
21hypertension10.2
22porphyria10.2
23cortical blindness - intellectual deficit - polydactyly10.2
24intracranial embolism10.1
25quadriplegia10.1
26sagittal sinus thrombosis10.1
27intracranial aneurysm10.1
28progressive multifocal leukoencephalopathy10.1
29agnosia10.1
30asthma10.1
31bacterial meningitis10.1
32cerebellar ataxia10.1
33encephalitis10.1
34hemiplegia10.1
35hydrocephalus10.1
36infective endocarditis10.1
37purpura10.1
38retinitis10.1
39sarcoidosis10.1
40cortical blindness mental retardation polydactyly10.1
41opa3-related 3-methylglutaconic aciduria10.0MT-ND4
42multiple sclerosis10.0ABCD1
43diabetes mellitus10.0MT-ND1
44leukodystrophy10.0ASPA
45blindness10.0MT-ND4, TIMM8A
46leber hereditary optic neuropathy with dystonia10.0MT-ND4, MT-ND6
47deafness-dystonia-optic neuronopathy syndrome10.0TIMM8A, TIMM13
48mitochondrial disorders10.0MT-ND4, MT-ND5
49optic nerve disease10.0MT-ND6, MT-ND4
50hemarthrosis10.0F3

Graphical network of the top 20 diseases related to Cortical Blindness:



Diseases related to cortical blindness

Clinical Features for Cortical Blindness

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Drugs & Therapeutics for Cortical Blindness

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cortical Blindness

Drug clinical trials:

Search ClinicalTrials for Cortical Blindness

Search NIH Clinical Center for Cortical Blindness

Search CenterWatch for Cortical Blindness

Genetic Tests for Cortical Blindness

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Anatomical Context for Cortical Blindness

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32MalaCards
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MalaCards organs/tissues related to Cortical Blindness:

32
Brain, Eye, Cortex, Liver, Occipital lobe, Heart, Testes, Bone marrow, Bone, Kidney, Endothelial, Spinal cord, Prostate, Placenta, Breast, Lung, Skeletal muscle, Amygdala

Animal Models for Cortical Blindness or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cortical Blindness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.5PRNP, F3, ABCD1, F2, ASPA, ALDH7A1
2MP:00036316.6ASPA, ISL2, MT-ND6, PRNP, POLG, F3

Publications for Cortical Blindness

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50PubMed
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Articles related to Cortical Blindness:

(show top 50)    (show all 375)
idTitleAuthorsYear
1
Meningioangiomatosis: a rare presentation with progressive cortical blindness. (23897877)
2013
2
Cortical blindness in a patient with eclampsia: posterior reversible encephalopathy syndrome. (23571395)
2013
3
Reversible acute cortical blindness associated with eclampsia in complete hydatidiform mole. (19562410)
2011
4
New approaches to visual rehabilitation for cortical blindness: outcomes and putative mechanisms. (20103505)
2010
5
A 3.1-Mb microdeletion of 3p21.31 associated with cortical blindness, cleft lip, CNS abnormalities, and developmental delay. (19100872)
2009
6
Sudden cortical blindness in an adult with moyamoya disease. (17320646)
2007
7
Nonrecurring transient cortical blindness after coronary angiography: a role for hypoventilation and hypercarbia? (16475183)
2006
8
Partial recovery from cortical blindness following carbon monoxide intoxication. (15768859)
2005
9
Transient cortical blindness with leptomeningeal enhancement after attempted peripherally inserted central venous catheter placement. (15883295)
2005
10
Cortical blindness after catheter angiography. (16159098)
2005
11
Transient cortical blindness after caesarean hysterectomy for placenta percreta. (15477065)
2004
12
Reversible cortical blindness after lung transplantation. (12938791)
2003
13
Functional magnetic resonance imaging mirrors recovery of visual perception after repetitive tachistoscopic stimulation in patients with partial cortical blindness. (12531465)
2003
14
Bilateral cortical blindness: an unusual complication following unilateral neck dissection. (11893271)
2002
15
Cortical blindness after subclavian arteriography. (10974726)
2000
16
An unusual case of cortical blindness associated with aortography--a case report. (10701723)
2000
17
Cortical blindness following coronary angiography. (11296788)
2000
18
Cortical blindness in acute intermittent porphyria. (10778597)
1999
19
Obstetrical anaesthesia for a parturient with preeclampsia, HELLP syndrome and acute cortical blindness. (9598260)
1998
20
Transient cortical blindness in liver cirrhosis. (9512132)
1998
21
Cortical blindness and Anton syndrome in a patient with obstetric hemorrhage. (9572170)
1998
22
Transient bilateral cortical blindness due to hypoxemia. (8669642)
1996
23
Transient bilateral cortical blindness as a presenting symptom of infective endocarditis. (8999363)
1996
24
Hypoglycemia and bilateral cortical blindness. (8742580)
1996
25
Selective impairments of object knowledge in a case of acquired cortical blindness. (8574873)
1995
26
Confusion, cortical blindness and fever. (7651265)
1995
27
Bilateral cortical blindness: an unusual presentation of bacterial endocarditis. (1443851)
1992
28
Nonbacterial thrombotic endocarditis and cortical blindness. (1443036)
1992
29
Postpartum pulmonary embolus as an unusual cause of cortical blindness. (2316572)
1990
30
Cortical blindness during chemotherapy: clinical, CT, and MR correlations. (2312856)
1990
31
Cortical blindness due to osmotic disruption of the blood-brain barrier by angiographic contrast material: CT and MRI studies. (2927682)
1989
32
Transient postictal cortical blindness. (2958507)
1987
33
Pre-eclampsia, "HELLP" syndrome and postictal cortical blindness. (3604599)
1987
34
Cortical blindness: etiology, diagnosis, and prognosis. (3827223)
1987
35
Cortical blindness in infancy. (3726955)
1986
36
Cortical blindness, growth and psychomotor retardation and postaxial polydactyly: a probably distinct autosomal recessive syndrome. (4064363)
1985
37
Cortical blindness after cerebral angiography. Case report. (7452339)
1981
38
Tourniquet subclavian steal: brainstem ischemia and cortical blindness--clinical significance and testing. (7304302)
1981
39
Cisplatin-associated cortical blindness. (7197656)
1981
40
Acute cortical blindness associated with hypoglycemia. (7205486)
1981
41
Seizures and transient cortical blindness associated with cis-platinum (II) diamminedichloride (PDD) therapy in a thirty-year-old man. (7188878)
1980
42
Transient cortical blindness following vertebral angiography. (721452)
1978
43
Scintigram in cortical blindness (Anton's syndrome). (719976)
1978
44
Cortical blindness after overlapping retinal-striate lesions: a limit to plasticity in the central visual system. (812586)
1976
45
Visual evoked responses in childhood cortical blindness after head trauma and meningitis. A longitudinal study of six cases. (4472425)
1974
46
VER in cortical blindness or bilateral homonymous visual defects. (5156807)
1971
47
Cortical blindness, fever, and convulsions--a misinterpretation. (5491456)
1970
48
Bilateral cortical blindness from cerebral infarction. (5423052)
1970
49
The visual-evoked cortical response in night blindness. (5297359)
1966
50
Cortical blindness with partial recovery following acute cerebral anoxia from cardiac arrest. (13593938)
1958

Genetic Variations for Cortical Blindness

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Expression for genes affiliated with Cortical Blindness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cortical Blindness

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Pathways for genes affiliated with Cortical Blindness

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Sources:
29KEGG, 53Reactome, 49PharmGKB, 51QIAGEN
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Compounds for genes affiliated with Cortical Blindness

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Cortical Blindness according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1isoleucine4410.0MT-ND6, MT-ND4, PRNP
2aprosulate449.9F3, F2
3napsagatran449.9F3, F2
4brodifacoum449.9F3, F2
5mnpt449.9F3, F2
6hemochron449.9F3, F2
7certoparin449.9F3, F2
8appt449.9F3, F2
9inogatran449.9F2, F3
10heparin sodium449.9F2, F3
11ecarin449.9F3, F2
12dextran 70449.9F3, F2
13spectrozyme449.9F2, F3
14polybrene449.9F2, F3
15s-warfarin449.8F3, F2
16danaparoid449.8F3, F2
17hepaplastin449.8F3, F2
18kaolin449.8F3, F2
19organon449.8F3, F2
20rivaroxaban44 1110.8F3, F2
21ximelagatran44 1110.8F3, F2
22vitamin k144 2410.8F3, F2
23nad28 2410.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, ALDH7A1
24heparinoids449.8F3, F2
25fondaparinux449.8F2, F3
26nadh44 11 2411.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, ALDH7A1
27acenocoumarol44 49 1111.7F3, F2
28bivalirudin44 1110.7F3, F2
29coumarins449.7F3, F2
30methionine449.7PRNP, MT-ND5, MT-ND1, MT-ND6
31phenprocoumon44 49 1111.6F3, F2
32valine449.6PRNP, MT-ND5, MT-ND4, MT-ND1, MT-ND6
33argatroban44 1110.6F3, F2
34hydroxyethyl starch449.6F3, F2
35ppack449.5F2, F3
36tirofiban44 1110.5F2, F3
37tranexamic acid44 1110.4F3, F2
38protamine sulfate449.2F3, F2
39atp44 2810.1MT-ND1, MT-ND4, MT-ND5, PRNP, POLG, ABCD1
40alanine448.6MT-ND6, MT-ND1, MT-ND5, PRNP, POLG, F3

GO Terms for genes affiliated with Cortical Blindness

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16Gene Ontology
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Biological processes related to Cortical Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chaperone-mediated protein transportGO:0723219.3TIMM8A, TIMM13
2sensory perception of soundGO:0076059.2ALDH7A1, SLC26A5, TIMM13

Products for genes affiliated with Cortical Blindness

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Sources for Cortical Blindness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet