MCID: CRT012
MIFTS: 44

Cortical Blindness malady

Summaries for Cortical Blindness

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64Wikipedia, 33MalaCards
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Wikipedia:64 Cortical blindness is the total or partial loss of vision in a normal-appearing eye caused by damage to... more...

MalaCards: Cortical Blindness, also known as blindness, cortical, is related to blindness and melas syndrome. An important gene associated with Cortical Blindness is MT-ND4 (mitochondrially encoded NADH dehydrogenase 4), and among its related pathways are Histidine metabolism and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds isoleucine and brodifacoum have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex, and related mouse phenotypes are normal and nervous system.

Aliases & Classifications for Cortical Blindness

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

cortical blindness 8 10
blindness, cortical 61


External Ids:

Disease Ontology8 DOID:11831
ICD9CM27 377.75
SNOMED-CT57 68574006
MeSH35 D019575

Related Diseases for Cortical Blindness

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cortical Blindness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1blindness31.8MT-ND4, TIMM8A
2melas syndrome30.1MT-ND6
3eclampsia10.5
4anton's syndrome10.4
5hellp syndrome10.3
6anosognosia10.3
7hypoglycemia10.3
8ataxia10.3
9status epilepticus10.2
10subacute sclerosing panencephalitis10.2
11acute intermittent porphyria10.2
12acute porphyria10.2
13asthma10.2
14head injury10.2
15cortical blindness - intellectual deficit - polydactyly10.2
16quadriplegia10.1
17sagittal sinus thrombosis10.1
18intracranial aneurysm10.1
19progressive multifocal leukoencephalopathy10.1
20agnosia10.1
21bacterial meningitis10.1
22cortical blindness mental retardation polydactyly10.1
23opa3-related 3-methylglutaconic aciduria10.0MT-ND4
24multiple sclerosis10.0ABCD1
25diabetes mellitus10.0MT-ND1
26leukodystrophy10.0ASPA
27neuropathy10.0POLG
28leber hereditary optic neuropathy with dystonia10.0MT-ND4, MT-ND6
29deafness-dystonia-optic neuronopathy syndrome10.0TIMM8A, TIMM13
30mitochondrial disorders10.0MT-ND4, MT-ND5
31optic nerve disease10.0MT-ND6, MT-ND4
32hemarthrosis10.0F3
33mitochondrial complex i deficiency10.0MT-ND6, MT-ND5
34nonsyndromic deafness10.0SLC26A5
35sensorineural hearing loss10.0TIMM8A, SLC26A5
36leigh disease10.0POLG, MT-ND5
37factor xii deficiency10.0F3
38urticaria10.0HNMT
39mitochondrial dna-associated leigh syndrome and narp10.0MT-ND1, MT-ND4, MT-ND5, MT-ND6
40leber hereditary optic neuropathy10.0MT-ND6, MT-ND1, MT-ND4, MT-ND5
41prion disease10.0F3, POLG
42lactic acidosis10.0MT-ND5, MT-ND4, MT-ND1, POLG
43dementia10.0TIMM8A, IFNA10, PRNP
44myopathy10.0PRNP, POLG
45acute liver failure10.0F2, POLG
46galactosemia10.0F2, F3
47factor x deficiency10.0F3, F2
48factor v deficiency10.0F2, F3
49vitamin k deficiency hemorrhagic disease10.0F3, F2
50factor xi deficiency10.0F2, F3

Graphical network of the top 20 diseases related to Cortical Blindness:



Diseases related to cortical blindness

Clinical Features for Cortical Blindness

Drugs & Therapeutics for Cortical Blindness

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cortical Blindness

Drug clinical trials:

Search ClinicalTrials for Cortical Blindness

Search NIH Clinical Center for Cortical Blindness

Search CenterWatch for Cortical Blindness

Genetic Tests for Cortical Blindness

Anatomical Context for Cortical Blindness

Sources:
33MalaCards
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MalaCards organs/tissues related to Cortical Blindness:

33
Bone marrow, Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Kidney, Liver, Lung, Breast, Placenta, Prostate, B lymphoblasts, B cells, Endothelial, Parietal lobe, Temporal lobe, Occipital lobe, Amygdala, Adrenal cortex

Animal Models for Cortical Blindness or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Cortical Blindness:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.5PRNP, F3, ABCD1, F2, ASPA, ALDH7A1
2MP:00036316.6ASPA, ISL2, MT-ND6, PRNP, POLG, F3

Publications for Cortical Blindness

Sources:
51PubMed
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Articles related to Cortical Blindness:

(show top 50)    (show all 376)
idTitleAuthorsYear
1
Cortical blindness in obstetric patients: Case report of two different presentations. (23959359)
2013
2
Transient cortical blindness as a manifestation of solitary cysticercus granuloma. (23230251)
2012
3
Transient cortical blindness after coronary angiography: a case report and literature review. (21465952)
2011
4
Methomyl-alphamethrin poisoning presented with cholinergic crisis, cortical blindness, and delayed peripheral neuropathy. (20923394)
2010
5
Cysticercal encephalitis with cortical blindness. (22791486)
2010
6
Dementia with Lewy bodies associated with ataxia, myoclonus, and cortical blindness. (20310054)
2010
7
Persistent cortical blindness after a thoracic epidural test dose of bupivacaine. (20068456)
2010
8
Cortical blindness due to sagittal sinus thrombosis in acute lymphoblastic leukaemia. (19006563)
2009
9
Visual restoration in cortical blindness: insights from natural and TMS-induced blindsight. (16864478)
2006
10
Cortical blindness after motorcycle accident: a case report. (16696424)
2006
11
Bilateral cortical blindness--Anton syndrome: case report. (16193699)
2005
12
Cortical blindness: clinical and radiologic findings in reversible posterior leukoencephalopathy syndrome: case report and review of the literature. (15691546)
2005
13
Cortical blindness due to reversible posterior leukoencephalopathy syndrome in a patient with thrombotic thrombocytopenic purpura and preeclampsia. (15596599)
2004
14
Late onset of cortical blindness in a patient with severe preeclampsia related to retained placental fragments. (12503005)
2003
15
Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome with acute cortical blindness. (11720149)
2001
16
A case of postictal cortical blindness detected by brain perfusion SPECT. (11452194)
2001
17
Antiphospholipid syndrome with cortical blindness resulting from infarction around the posterior cerebral artery in an elderly woman. (10888218)
2000
18
Cortical blindness in a preeclamptic patient after a cesarean delivery complicated by hypotension. (10960386)
2000
19
Cortical blindness in severe preeclampsia: computed tomography, magnetic resonance imaging, and single-photon-emission computed tomography findings. (10808010)
2000
20
Cortical blindness as a manifestation of hypomagnesemia secondary to cisplatin therapy: case report and review of literature. (9889044)
1999
21
Transient cortical blindness in preeclampsia with indication of generalized vascular endothelial damage. (9736196)
1998
22
Complete sparing of high-contrast color input to motion perception in cortical color blindness. (10195150)
1998
23
Delayed cortical blindness and recurrent quadriplegia after cervical trauma. (9884301)
1998
24
The wounding of Alexander the Great in Cyropolis (329 BC): the first reported case of the syndrome of transient cortical blindness? (9406375)
1997
25
D-2-hydroxyglutaric aciduria: hypotonia, cortical blindness, seizures, cardiomyopathy, and cylindrical spirals in skeletal muscle. (9010793)
1997
26
Reversible cortical blindness and convulsions with cyclosporin A toxicity in a patient undergoing allogeneic peripheral stem cell transplantation. (9384485)
1997
27
Cortical blindness in a 35-year-old man. (8733542)
1996
28
Cortical blindness and visual imagery. (8848191)
1995
29
Reversible cyclosporine-induced cortical blindness in allogeneic bone marrow transplant recipients. (7773219)
1995
30
Cortical blindness following cerebral angiography. (8533402)
1995
31
Retinopathy of prematurity and cortical blindness. (7761236)
1995
32
Progressive multifocal leukoencephalopathy (PML) in two cases of cortical blindness. (11362130)
1994
33
Ictal cortical blindness: a case report and review of the literature. (8405722)
1993
34
Cortical blindness--a catastrophic side effect of vincristine. (1421432)
1992
35
Reversible cortical blindness (Anton's syndrome) associated with bilateral occipital EEG abnormalities. (2335039)
1990
36
Transient cortical blindness in a severe preeclamptic. (2304696)
1990
37
Anton syndrome and cortical blindness due to bilateral occipital infarction. (2638312)
1989
38
Ictal cortical blindness with permanent visual loss. (2492221)
1989
39
Recovery from cortical blindness mediated by destruction of nontectotectal fibers in the commissure of the superior colliculus in the cat. (2754044)
1989
40
Cortical blindness after subclavian vein catheterization. (3184426)
1988
41
Nonspecific dementia, cortical blindness, and Congophilic angiopathy. A clinicopathological report. (3819782)
1987
42
Transient cortical blindness in a child. (3800098)
1987
43
Cortical blindness complicating Wegener's granulomatosis. (3918713)
1985
44
Cortical blindness as a complication of eclampsia. (6711935)
1984
45
Cortical blindness: the changing incidence and shifting etiology. (7367354)
1980
46
Prolonged cortical blindness after closed head trauma. (644375)
1978
47
Acute hemiplegia and cortical blindness due to moya moya disease: report of a case in a child with Down's syndrome. (141647)
1977
48
Visual evoked potentials and postmortem findings in a case of cortical blindness. (569461)
1977
49
Cortical blindness with anosognosia subsequent simultaneous agnosia and persistent gross recent memory defect. (4469638)
1974
50
Cortical blindness following convulsions and fever in Nigerian children. (5423436)
1970

Genetic Variations for Cortical Blindness

Expression for genes affiliated with Cortical Blindness

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cortical Blindness

Search GEO for disease gene expression data for Cortical Blindness.

Pathways for genes affiliated with Cortical Blindness

Sources:
30KEGG, 54Reactome, 50PharmGKB, 52QIAGEN
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Compounds for genes affiliated with Cortical Blindness

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB
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Compounds related to Cortical Blindness according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1isoleucine4510.0MT-ND6, MT-ND4, PRNP
2brodifacoum459.9F2, F3
3mnpt459.9F2, F3
4napsagatran459.9F2, F3
5aprosulate459.9F2, F3
6certoparin459.9F2, F3
7hemochron459.9F2, F3
8appt459.9F3, F2
9inogatran459.9F3, F2
10heparin sodium459.9F2, F3
11dextran 70459.9F3, F2
12ecarin459.9F2, F3
13polybrene459.9F2, F3
14spectrozyme459.9F3, F2
15hepaplastin459.8F2, F3
16s-warfarin459.8F3, F2
17danaparoid459.8F3, F2
18rivaroxaban45 1110.8F2, F3
19organon459.8F2, F3
20kaolin459.8F2, F3
21ximelagatran45 1110.8F2, F3
22vitamin k145 2410.8F3, F2
23nad29 2410.8MT-ND6, MT-ND5, MT-ND4, MT-ND1, ALDH7A1
24heparinoids459.8F2, F3
25fondaparinux459.8F3, F2
26nadh45 11 2411.8MT-ND5, MT-ND4, ALDH7A1, MT-ND1, MT-ND6
27acenocoumarol45 50 1111.7F2, F3
28bivalirudin45 1110.7F2, F3
29coumarins459.7F2, F3
30methionine459.7MT-ND6, MT-ND1, PRNP, MT-ND5
31phenprocoumon45 50 1111.6F2, F3
32valine459.6MT-ND4, MT-ND5, PRNP, MT-ND6, MT-ND1
33hydroxyethyl starch459.6F3, F2
34argatroban45 1110.6F2, F3
35ppack459.5F2, F3
36tirofiban45 1110.5F2, F3
37tranexamic acid45 1110.4F3, F2
38protamine sulfate459.2F3, F2
39atp45 2910.1ABCD1, POLG, PRNP, MT-ND5, MT-ND4, MT-ND1
40alanine458.6MT-ND1, MT-ND5, PRNP, POLG, F3, F2

GO Terms for genes affiliated with Cortical Blindness

Sources:
16Gene Ontology
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Biological processes related to Cortical Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chaperone-mediated protein transportGO:0723219.3TIMM8A, TIMM13
2sensory perception of soundGO:0076059.2ALDH7A1, SLC26A5, TIMM13

Products for genes affiliated with Cortical Blindness

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Sources for Cortical Blindness

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet