MCID: CRT012
MIFTS: 45

Cortical Blindness malady

Summaries for Cortical Blindness

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cortical blindness is the total or partial loss of vision in a normal-appearing eye caused by damage to... more...

MalaCards: Cortical Blindness, also known as blindness, cortical, is related to dementia and melas syndrome. An important gene associated with Cortical Blindness is MT-ND4 (mitochondrially encoded NADH dehydrogenase 4), and among its related pathways are Histidine metabolism and Gamma-carboxylation, transport, and amino-terminal cleavage of proteins. The compounds isoleucine and aprosulate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are normal and nervous system.

Aliases & Classifications for Cortical Blindness

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

cortical blindness 8 10
blindness, cortical 60


External Ids:

Disease Ontology8 DOID:11831
ICD9CM27 377.75
SNOMED-CT56 68574006
MeSH34 D019575

Related Diseases for Cortical Blindness

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cortical Blindness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.2TIMM8A, IFNA10, PRNP
2melas syndrome30.1MT-ND6
3neuropathy29.9POLG
4cerebritis10.6
5eclampsia10.5
6meningitis10.4
7glomerulonephritis10.3
8anosognosia10.2
9hypoglycemia10.2
10cervicitis10.2
11endocarditis10.2
12influenza10.2
13pre-eclampsia10.2
14hellp syndrome10.2
15status epilepticus10.2
16subacute sclerosing panencephalitis10.2
17acute intermittent porphyria10.2
18acute porphyria10.2
19hepatic encephalopathy10.2
20hepatitis10.2
21hypertension10.2
22porphyria10.2
23cortical blindness - intellectual deficit - polydactyly10.2
24intracranial embolism10.1
25quadriplegia10.1
26sagittal sinus thrombosis10.1
27intracranial aneurysm10.1
28progressive multifocal leukoencephalopathy10.1
29agnosia10.1
30asthma10.1
31bacterial meningitis10.1
32cerebellar ataxia10.1
33encephalitis10.1
34hemiplegia10.1
35hydrocephalus10.1
36infective endocarditis10.1
37purpura10.1
38retinitis10.1
39sarcoidosis10.1
40cortical blindness mental retardation polydactyly10.1
41opa3-related 3-methylglutaconic aciduria10.0MT-ND4
42multiple sclerosis10.0ABCD1
43diabetes mellitus10.0MT-ND1
44leukodystrophy10.0ASPA
45blindness10.0MT-ND4, TIMM8A
46leber hereditary optic neuropathy with dystonia10.0MT-ND4, MT-ND6
47deafness-dystonia-optic neuronopathy syndrome10.0TIMM8A, TIMM13
48mitochondrial disorders10.0MT-ND4, MT-ND5
49optic nerve disease10.0MT-ND6, MT-ND4
50hemarthrosis10.0F3

Graphical network of the top 20 diseases related to Cortical Blindness:



Diseases related to cortical blindness

Clinical Features for Cortical Blindness

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Drugs & Therapeutics for Cortical Blindness

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cortical Blindness

Drug clinical trials:

Search ClinicalTrials for Cortical Blindness

Search NIH Clinical Center for Cortical Blindness

Search CenterWatch for Cortical Blindness

Genetic Tests for Cortical Blindness

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Anatomical Context for Cortical Blindness

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32MalaCards
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MalaCards organs/tissues related to Cortical Blindness:

32
Brain, Eye, Cortex, Liver, Occipital lobe, Heart, Testes, Bone marrow, Bone, Kidney, Endothelial, Spinal cord, Prostate, Placenta, Breast, Lung, Skeletal muscle, Amygdala

Animal Models for Cortical Blindness or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cortical Blindness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.5PRNP, F3, ABCD1, F2, ASPA, ALDH7A1
2MP:00036316.6ASPA, ISL2, MT-ND6, PRNP, POLG, F3

Publications for Cortical Blindness

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50PubMed
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Articles related to Cortical Blindness:

(show top 50)    (show all 375)
idTitleAuthorsYear
1
Cortical blindness following posterior lumbar decompression and fusion. (23791834)
2014
2
Cortical Blindness due to Bilateral Occipital Infarcts in a Renal Failure Patient with Prostate Cancer: A Rare Complication of Hemodialysis. (23424594)
2013
3
Transient cortical blindness after spinal surgery as initial presenting sign of hereditary thrombophilia. (23514658)
2013
4
Cortical blindness and posterior reversible encephalopathy syndrome in an older patient. (22669215)
2012
5
Transient cortical blindness following a Hangman's fracture: a case report and review of literature. (22026474)
2012
6
Transient cortical blindness after thoracic endovascular aneurysm repair. (21276688)
2011
7
Differential impact of partial cortical blindness on gaze strategies when sitting and walking - an immersive virtual reality study. (21414339)
2011
8
Permanent bilateral cortical blindness due to reversible posterior leukoencephalopathy syndrome. (21720093)
2011
9
Extrapontine myelinolysis resulting in transient cortical blindness. (20117757)
2010
10
A 16-year old male with cortical blindness and focal motor seizures. (21085540)
2010
11
Acute intermittent porphyria with transient cortical blindness. (21149904)
2010
12
Postpartum cortical blindness. (18803903)
2008
13
Cortical blindness during coil embolization of an unruptured intracranial aneurysm--case report. (15508349)
2004
14
Cortical blindness and hepatic encephalopathy. (12859270)
2003
15
Mind-the gap, after 65 years: visual conditioning in cortical blindness. (12538395)
2003
16
Parietal contusion and transient superior sagittal sinus occlusion presenting with cortical blindness. (12435960)
2002
17
Bilateral cortical blindness associated with cerebral angiitis. (12181712)
2002
18
Visual hallucinations in recovery from cortical blindness: imaging correlates. (10768632)
2000
19
Transient cortical blindness after coronary angiography. (9605831)
1998
20
Cortical blindness after a failed free tissue transfer: a case report and review of the literature. (7793793)
1995
21
Subacute sclerosing panencephalitis presenting as cortical blindness. (9053395)
1995
22
Transient cortical blindness and bioccipital brain lesions in two patients with acute intermittent porphyria. (7677301)
1995
23
Visual object agnosia, prosopagnosia, achromatopsia, loss of visual imagery, and autobiographical amnesia following recovery from cortical blindness: case M.H. (8341415)
1993
24
Cortical blindness due to cyclosporin. (8232697)
1993
25
Golgi-Kopsch silver study of the brain of a patient with untreated phenylketonuria, seizures, and cortical blindness. (1442885)
1992
26
Cortical blindness and residual vision: is the "second" visual system in humans capable of more than rudimentary visual perception? (2046931)
1991
27
Convulsions and transient cortical blindness after cisplatin. (2004162)
1991
28
VEP and EEG in cortical blindness: a case with a complicated course. (2081688)
1990
29
Posttraumatic cortical blindness: are we missing the diagnosis in children? (2290728)
1990
30
Transient cortical blindness following cerebral angiography. (2592849)
1989
31
Antepartum cortical blindness. (3399924)
1988
32
Anton's (-Redlich-Babinski's) syndrome associated with Dide-Botcazo's syndrome: a case report of denial of cortical blindness and amnesia. (2451281)
1988
33
A long-term cortical blindness after head trauma. (3626192)
1987
34
A case of cortical blindness due to carbon monoxide poisoning. (3570723)
1987
35
Cortical blindness in acute carbon monoxide poisoning. (4083389)
1985
36
Hydrocephalus and transient cortical blindness. (6507566)
1984
37
Cortical blindness after metrizamide myelography. Report of a case and proposed pathophysiologic mechanism. (6691831)
1984
38
Cortical blindness in infancy: a follow-up study. (6657185)
1983
39
Isolated cortical blindness in pregnancy. (7179953)
1982
40
Cortical blindness and homonymous hemianopia in the postpartum period. (6776298)
1980
41
Quadriplegia and cortical blindness in Hemophilus influenzae meningitis. (671161)
1978
42
Cortical blindness as a complication of hemodialysis. (712505)
1978
43
Cortical blindness in cranial arteritis. (1174488)
1975
44
Observations on cortical blindness and on vascular lesions that cause loss of recent memory. (1151413)
1975
45
Varicella encephalitis with cortical blindness. (4461695)
1974
46
Transient cortical blindness: still an "overlooked" syndrome? (5442371)
1970
47
Transient cortical blindness. An unusual complication of coronary angiography. (5534969)
1970
48
Transitory cortical blindness in head injury. (5366462)
1969
49
Prognosis of cortical blindness following cardiac arrest in children. (14005700)
1962
50
A rare presenile dementia associated with cortical blindness (Heidenhain's syndrome). (13163704)
1954

Genetic Variations for Cortical Blindness

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Expression for genes affiliated with Cortical Blindness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cortical Blindness

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Pathways for genes affiliated with Cortical Blindness

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Sources:
29KEGG, 53Reactome, 49PharmGKB, 51QIAGEN
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Compounds for genes affiliated with Cortical Blindness

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Cortical Blindness according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1isoleucine4410.0MT-ND6, MT-ND4, PRNP
2aprosulate449.9F3, F2
3napsagatran449.9F3, F2
4brodifacoum449.9F3, F2
5mnpt449.9F3, F2
6hemochron449.9F3, F2
7certoparin449.9F3, F2
8appt449.9F3, F2
9inogatran449.9F2, F3
10heparin sodium449.9F2, F3
11ecarin449.9F3, F2
12dextran 70449.9F3, F2
13spectrozyme449.9F2, F3
14polybrene449.9F2, F3
15s-warfarin449.8F3, F2
16danaparoid449.8F3, F2
17hepaplastin449.8F3, F2
18kaolin449.8F3, F2
19organon449.8F3, F2
20rivaroxaban44 1110.8F3, F2
21ximelagatran44 1110.8F3, F2
22vitamin k144 2410.8F3, F2
23nad28 2410.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, ALDH7A1
24heparinoids449.8F3, F2
25fondaparinux449.8F2, F3
26nadh44 11 2411.8MT-ND6, MT-ND1, MT-ND4, MT-ND5, ALDH7A1
27acenocoumarol44 49 1111.7F3, F2
28bivalirudin44 1110.7F3, F2
29coumarins449.7F3, F2
30methionine449.7PRNP, MT-ND5, MT-ND1, MT-ND6
31phenprocoumon44 49 1111.6F3, F2
32valine449.6PRNP, MT-ND5, MT-ND4, MT-ND1, MT-ND6
33argatroban44 1110.6F3, F2
34hydroxyethyl starch449.6F3, F2
35ppack449.5F2, F3
36tirofiban44 1110.5F2, F3
37tranexamic acid44 1110.4F3, F2
38protamine sulfate449.2F3, F2
39atp44 2810.1MT-ND1, MT-ND4, MT-ND5, PRNP, POLG, ABCD1
40alanine448.6MT-ND6, MT-ND1, MT-ND5, PRNP, POLG, F3

GO Terms for genes affiliated with Cortical Blindness

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16Gene Ontology
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Biological processes related to Cortical Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chaperone-mediated protein transportGO:0723219.3TIMM8A, TIMM13
2sensory perception of soundGO:0076059.2ALDH7A1, SLC26A5, TIMM13

Products for genes affiliated with Cortical Blindness

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Sources for Cortical Blindness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet