CBGD
MCID: CRT033
MIFTS: 59

Corticobasal Degeneration (CBGD) malady

Genetic diseases, Rare diseases, Neuronal diseases categories
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Summaries for Corticobasal Degeneration

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NINDS:43 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards based summary: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to progressive supranuclear palsy and aphasia. An important gene associated with Corticobasal Degeneration is MAPT (microtubule-associated protein tau), and among its related pathways are MNAR-PELP1 and Estrogen Receptor Interaction and Development Leptin signaling via JAK STAT and MAPK cascades. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and eye, and related mouse phenotypes are taste/olfaction and tumorigenesis.

NIH Rare Diseases:42 Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/4/2010

Wikipedia:65 Corticobasal degeneration (CBD) or Corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

Aliases & Classifications for Corticobasal Degeneration

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Sources:
42NIH Rare Diseases, 43NINDS, 48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Corticobasal Degeneration, Aliases & Descriptions:

Name: Corticobasal Degeneration 42 43 48 62
Cortical-Basal Ganglionic Degeneration 42
Cortical Basal Ganglionic Degeneration 62
 
Cortico-Basal Ganglionic Degeneration 42
Cbgd 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
corticobasal degeneration:
Prevalence: 1-9/100000; Age of onset: Adulthood


External Ids:

ICD10 via Orphanet26 G31.0
UMLS via Orphanet63 C0393570

Related Diseases for Corticobasal Degeneration

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Diseases in the Corticobasal Degeneration family:

Corticobasal Degeneration, Mapt-Related

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1progressive supranuclear palsy32.0HCRT, SNCA, RPS27A, MAPT
2aphasia31.6TARDBP, MAPT
3primary progressive aphasia31.6MAPT, RPS27A
4frontotemporal dementia31.4TARDBP, MAPT, RPS27A, SNCA
5pick's disease31.4TARDBP, MAPT, RPS27A, SNCA
6tauopathy31.4SNCA, RPS27A, MAPT
7semantic dementia31.3RPS27A, MAPT
8multiple system atrophy31.2MAPT, RPS27A, SNCA
9creutzfeldt-jakob disease31.2SNCA, RPS27A, MAPT
10rem sleep behavior disorder31.1SNCA
11dementia31.0GBA, HCRT, SNCA, RPS27A, MAPT, MAPK3
12lateral sclerosis31.0SNCA, MAPT
13parkinson's disease30.9GBA, PITX3, SNCA, RPS27A, MAPT
14normal pressure hydrocephalus30.9HCRT, MAPT
15motor neuron disease30.8SNCA, RPS27A, MAPT, TARDBP
16huntington's disease30.8CASP3
17striatonigral degeneration30.7SNCA, RPS27A
18alzheimer's disease29.4HRAS, HCRT, HSPB2, PRDX5, TARDBP, HMOX1
19apraxia10.9
20cerebritis10.7
21neuronitis10.6
22myoclonus10.6
23neuronal intranuclear inclusion disease10.6RPS27A
24hypersplenism10.4GBA
25dystonia10.4
26inclusion body myositis10.4MAPT, RPS27A
27parkinson disease 110.4SNCA
28myotonic dystrophy10.4MAPT, HSPB2, HCRT
29neuroblastoma10.4MYC
30parkinson disease type 310.4SNCA, MAPT
31neuroaxonal dystrophy10.3SNCA, RPS27A
32hemiparkinsonism-hemiatrophy syndrome10.3
33central nervous system disease10.3HCRT, MAPT, HMOX1
34niemann-pick disease type c110.3MAPT, SNCA, HCRT
35lewy body dementia10.3MAPT, RPS27A, SNCA
36vascular dementia10.3SNCA, RPS27A, MAPT
37spinocerebellar ataxia10.3MAPT, RPS27A, SNCA
38amyotrophic lateral sclerosis10.3
39corticobasal degeneration, mapt-related10.3
40movement disease10.3MAPT, RPS27A, SNCA
41myositis10.3MAPT, RPS27A, SNCA
42brain disease10.3HCRT, SNCA, MAPT
43amyloidosis10.3MAPT, RPS27A, SNCA
44machado-joseph disease10.2SNCA, RPS27A
45pancytopenia10.2GBA, CSF3
46hydrocephalus10.1
47pulmonary fibrosis10.1
48olivopontocerebellar atrophy10.1
49neuroleptic malignant syndrome10.1
50parametritis10.1

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to corticobasal degeneration

Symptoms for Corticobasal Degeneration

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Drugs & Therapeutics for Corticobasal Degeneration

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Drug clinical trials:

Search ClinicalTrials for Corticobasal Degeneration

Search NIH Clinical Center for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

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Anatomical Context for Corticobasal Degeneration

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MalaCards organs/tissues related to Corticobasal Degeneration:

32
Cortex, Brain, Eye, Spinal cord, Thalamus

Animal Models for Corticobasal Degeneration or affiliated genes

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MGI Mouse Phenotypes related to Corticobasal Degeneration:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2SNCA, MAPK1, MAPT, CASP3
2MP:00020068.7MYC, MAPK1, MAPT, MAPK3, HRAS
3MP:00053798.4HRAS, HMOX1, CASP3, SNCA, MYC, PITX3
4MP:00053708.3GBA, PITX3, MYC, MAPK1, MAPK3, HMOX1
5MP:00053888.1GBA, PITX3, HCRT, MAPK1, MAPK3, CASP3
6MP:00053697.8HCRT, HSPB2, MYC, MAPK1, MAPT, MAPK3
7MP:00053907.8GBA, PITX3, HSPB2, MYC, SNCA, CASP3
8MP:00053677.7CFL1, SNCA, MAPT, CSF3, CASP3, HMOX1
9MP:00030127.6PITX3, CFL1, MYC, SNCA, MAPT, CASP3
10MP:00053977.2GBA, PITX3, MYC, MAPK1, MAPT, MAPK3
11MP:00053856.7GBA, HCRT, CFL1, HSPB2, MYC, SNCA
12MP:00053876.5SNCA, MYC, HSPB2, PITX3, GBA, MAPK1
13MP:00107716.5GBA, PITX3, CFL1, MYC, SNCA, MAPK1
14MP:00053766.4MYC, CFL1, HCRT, PITX3, GBA, SNCA
15MP:00107686.4SNCA, MYC, HSPB2, CFL1, GBA, MAPK1
16MP:00053846.2MYC, HSPB2, CFL1, PITX3, GBA, SNCA
17MP:00036316.1HSPB2, CFL1, HCRT, PITX3, GBA, MYC
18MP:00053865.8HRAS, GBA, PITX3, HCRT, CFL1, HSPB2
19MP:00053785.8MYC, HSPB2, CFL1, HCRT, PITX3, GBA

Publications for Corticobasal Degeneration

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Articles related to Corticobasal Degeneration:

(show top 50)    (show all 377)
idTitleAuthorsYear
1
A disease-specific metabolic brain network associated with corticobasal degeneration. (25208922)
2014
2
Argyrophilic grains are reliable disease-specific features of corticobasal degeneration. (24335531)
2014
3
Analysis of PITX3 gene in patients with multisystem atrophy, progressive supranuclear palsy and corticobasal degeneration. (23694789)
2013
4
A case of an arachnoid cyst masquerading as corticobasal degeneration. (23061395)
2012
5
A case of Creutzfeldt-Jakob disease mimicking corticobasal degeneration: FDG PET, SPECT, and MRI findings. (22691528)
2012
6
Acalculia in autopsy-proven corticobasal degeneration. (21321355)
2011
7
Seizures in corticobasal degeneration: a case report. (19544144)
2009
8
Clinicopathological and genetic correlates of frontotemporal lobar degeneration and corticobasal degeneration. (18357425)
2008
9
Corticobasal degeneration: clinical aspects. (18631773)
2008
10
Dysfunctional facial emotional expression and comprehension in a patient with corticobasal degeneration. (17786775)
2007
11
Co-occurrence of radiological features of progressive supranuclear palsy and corticobasal degeneration. (17272907)
2007
12
Rapid eye movement (REM) sleep without atonia in two patients with corticobasal degeneration (CBD). (17055327)
2007
13
Corticobasal degeneration. (18808957)
2007
14
The clinical overlap between the corticobasal degeneration syndrome and other diseases of the frontotemporal spectrum: three case reports. (17726244)
2007
15
Sporadic SCA8 mutation resembling corticobasal degeneration. (15823478)
2005
16
Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases. (15735950)
2005
17
Creutzfeldt-Jakob disease mimicking corticobasal degeneration clinical and MRI data of a case. (15795791)
2005
18
Neurosyphilis masquerading as corticobasal degeneration. (15389980)
2004
19
Rapid onset of pergolide-induced pulmonary fibrosis in a patient with corticobasal degeneration. (15222217)
2004
20
Corticobasal degeneration syndrome with basal ganglia calcification: Fahr's disease as a corticobasal look-alike? (12621646)
2003
21
Limb-kinetic apraxia in corticobasal degeneration: clinical and kinematic features. (12518300)
2003
22
Cholinergic neuronal loss in the basal forebrain and mesopontine tegmentum of progressive supranuclear palsy and corticobasal degeneration. (12536222)
2003
23
Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction. (14581681)
2003
24
Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration. (12084445)
2002
25
Unilateral periodic limb movements during sleep in corticobasal degeneration. (11748759)
2001
26
Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy. (11303763)
2001
27
Rhythmic cortical and muscle discharges induced by fatigue in corticobasal degeneration. (10699413)
2000
28
Phenotypes and prognosis: clinicopathologic studies of corticobasal degeneration. (10624482)
2000
29
Aphasia in corticobasal degeneration. (10624476)
2000
30
Immunohistochemistry distinguishes: between Pick's disease and corticobasal degeneration. (11185644)
2000
31
Neuropsychiatric aspects of corticobasal degeneration. (10624478)
2000
32
The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. (11087783)
2000
33
Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease. (10965796)
2000
34
Cerebral blood flow in corticobasal degeneration and progressive supranuclear palsy. (10718204)
2000
35
Contribution of PET studies in diagnosis of corticobasal degeneration. (10894990)
2000
36
Cognitive and magnetic resonance imaging aspects of corticobasal degeneration and progressive supranuclear palsy. (10449111)
1999
37
Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms. (10037497)
1999
38
A comparison of tau protein in cerebrospinal fluid between corticobasal degeneration and progressive supranuclear palsy. (10025574)
1999
39
Heterogeneity of glucose metabolism in corticobasal degeneration. (9879684)
1998
40
Neuropsychological and neuroimaging correlates in corticobasal degeneration. (10933454)
1998
41
Increased CSF tau protein in corticobasal degeneration. (9457628)
1998
42
Paired helical filaments in corticobasal degeneration: the fine fibrillary structure with NanoVan. (9409702)
1997
43
Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy. (8702002)
1996
44
Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy. (7572077)
1995
45
Unique myoclonic pattern in corticobasal degeneration. (7753055)
1995
46
Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy. (7985491)
1994
47
Unusual case of corticobasal degeneration with tau/Gallyas-positive neuronal and glial tangles. (7879609)
1994
48
Corticobasal degeneration: a report of three cases. (8046710)
1994
49
Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy. (7526285)
1994
50
Corticobasal degeneration: decreased and asymmetrical glucose consumption as studied with PET. (1484530)
1992

Variations for Corticobasal Degeneration

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Expression for genes affiliated with Corticobasal Degeneration

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Expression patterns in normal tissues for genes affiliated with Corticobasal Degeneration

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Pathways for genes affiliated with Corticobasal Degeneration

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Pathways related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HRAS, MAPK3, MAPK1
2
Show member pathways
9.5HRAS, MAPK3, MAPK1
39.5MAPK1, MAPK3, HRAS
49.4MAPK1, MAPK3, MYC
5
Show member pathways
Cytoskeleton remodeling Reverse signaling by ephrin B60
9.3MAPK1, MAPT, MAPK3, HRAS
6
Show member pathways
9.3MAPK3, RPS27A, HRAS, MAPK1
7
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.2HRAS, MAPK3, MAPK1, MYC
8
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.2HRAS, MAPK1, MYC, MAPK3
9
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.2MAPK3, MAPK1, HRAS, MYC
109.2HRAS, MAPK1, MAPK3, MYC
119.2MAPK1, HRAS, MAPK3, MYC
12
Show member pathways
EPO Receptor Signaling37
EPO signaling pathway37
9.2HRAS, MYC, MAPK1, MAPK3
139.2MAPK3, MAPK1, MYC, HRAS
14
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
9.2MYC, MAPK1, HRAS, MAPK3
15
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.2MYC, MAPK1, MAPK3, HRAS
169.2MAPK3, HRAS, MYC, MAPK1
17
Show member pathways
9.2HRAS, MAPK3, MYC, MAPK1
18
Show member pathways
9.1HRAS, MAPK3, CASP3, MAPK1
19
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.1HRAS, CASP3, MAPK3, MAPK1
20
Show member pathways
9.1HRAS, MAPK1, MAPK3, CASP3
219.1MAPK3, CASP3, HRAS, MAPK1
229.0MYC, MAPK3, CASP3, MAPK1
23
Show member pathways
IL-2 Signaling pathway37
9.0MAPT, MAPK1, MYC, HRAS, MAPK3
248.9HRAS, MAPT, MAPK1, CASP3, MAPK3
25
Show member pathways
Alzheimers Disease37
8.9SNCA, MAPK1, MAPT, CASP3, MAPK3
268.8CASP3, MAPK3, MAPT, MAPK1, MYC
278.8HRAS, MAPK3, MAPK1, MYC, SNCA
288.8MAPK1, CASP3, HMOX1, HRAS, MYC
298.8MYC, MAPK1, CASP3, HRAS, MAPK3
30
Show member pathways
Signal transduction PTEN pathway60
8.8HRAS, MAPK3, CASP3, MYC, MAPK1
31
Show member pathways
8.8MYC, CASP3, MAPK3, MAPK1, HRAS
32
Show member pathways
8.8HRAS, CASP3, MAPK3, MAPK1, MYC
33
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.8MAPK1, MAPK3, CASP3, HRAS, MYC
34
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
8.8MAPK1, CASP3, HRAS, MYC, MAPK3
35
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8MAPK1, MAPK3, CASP3, HRAS, MYC
36
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
8.8HRAS, CASP3, MAPK3, MAPK1, MYC
378.7CFL1, MAPK1, MAPK3, HRAS
38
Show member pathways
RAC1 signaling pathway37
8.7MAPK1, MAPK3, HRAS, CFL1
398.6HRAS, MYC, MAPK1, MAPK3, CSF3
40
Show member pathways
8.6MAPK1, CASP3, MAPT, MAPK3, SNCA, HRAS
418.6CASP3, MAPK3, CFL1, MAPK1
42
Show member pathways
8.3CASP3, MAPK3, CFL1, MAPK1, HRAS
438.3CASP3, HRAS, MYC, HSPB2, MAPK3, MAPK1
44
Show member pathways
8.3MYC, MAPK1, MAPK3, CSF3, CASP3, HRAS
458.1MAPK3, MAPT, CASP3, HRAS, MAPK1, CFL1
46
Show member pathways
MAPK signaling pathway37
8.1HSPB2, MAPK1, MAPT, MAPK3, CASP3, HRAS
47
Show member pathways
8.0MAPK3, MAPK1, MYC, CFL1, CASP3, HRAS
48
Show member pathways
7.8CFL1, MAPK1, MAPK3, CSF3, HRAS, CASP3
49
Show member pathways
7.8CFL1, MAPK3, MYC, MAPK1, CASP3, MAPT
50
Show member pathways
7.4MAPK1, MAPK3, CSF3, CASP3, CFL1, MYC

Compounds for genes affiliated with Corticobasal Degeneration

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Compounds related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1thioflavine s4410.1MAPT, RPS27A, SNCA
2formate449.4RPS27A, SNCA, MAPT, PRDX5
3radicicol44 61 1111.4HSPB2, RPS27A, MAPK1, MAPK3
46-hydroxydopamine449.3SNCA, CASP3, MYC, HMOX1, RPS27A
5rotenone449.3RPS27A, MAPK1, CASP3, HMOX1, SNCA
6roscovitine449.2MAPT, CASP3, MYC, MAPK1, MAPK3
7nmda44 2810.2MAPK3, MAPK1, RPS27A, HRAS, HCRT, MAPT
8herbimycin a44 6110.2RPS27A, HRAS, MAPK3, MYC, MAPK1
9sp 60012544 6110.2SNCA, CASP3, MAPK3, HMOX1, MAPK1
10sulforaphane449.1PRDX5, MAPK1, CASP3, HMOX1
11acetylcholine44 50 28 24 1113.0HCRT, HSPB2, SNCA, RPS27A, MAPT, HMOX1
12valine449.0SNCA, RPS27A, MAPT, CSF3, HRAS
13butyrate449.0CASP3, MAPK3, MAPT, MAPK1, MYC, RPS27A
14actinomycin d448.9MYC, RPS27A, MAPT, CASP3, HMOX1, MAPK1
15quercetin44 61 24 1111.8HSPB2, MAPK1, MAPK3, CASP3, HMOX1
16resveratrol44 61 24 1111.8CASP3, MAPK3, MAPK1, PRDX5, HMOX1
17imatinib44 50 1110.8MYC, RPS27A, MAPK1, CSF3, CASP3
18ly294002448.8HRAS, CASP3, MAPK3, MAPK1, MYC, HMOX1
19thapsigargin44 619.8HCRT, CASP3, MAPK3, MAPK1, HSPB2
20lactacystin448.8MAPK1, SNCA, HMOX1, RPS27A, CASP3, MAPT
21mg 13244 619.8RPS27A, SNCA, MYC, MAPK1, HMOX1, CASP3
22genistein44 28 61 2 24 1113.7MYC, HRAS, CASP3, MAPK3, MAPT, MAPK1
23melphalan44 50 1110.7PRDX5, MAPK3, MYC, CSF3
24sb 20358044 619.6HSPB2, SNCA, HMOX1, CASP3, MAPK3, MAPK1
25rapamycin448.6HRAS, CASP3, RPS27A, SNCA, MAPK3, MAPK1
26pd 98,059448.5HRAS, MAPK1, CASP3, MYC, HSPB2, MAPK3
27dopamine44 28 24 1111.5PITX3, HCRT, SNCA, RPS27A, MAPK3, MAPT
28paclitaxel44 50 1110.5CASP3, HRAS, CSF3, MAPK3, MAPT, MAPK1
29arsenite44 249.4HMOX1, CASP3, MAPK3, MAPK1, MYC, HSPB2
30pge2448.4HRAS, HMOX1, MAPK3, MAPK1, RPS27A, SNCA
31dexamethasone44 50 28 1111.4HCRT, MYC, RPS27A, MAPK1, MAPK3, CSF3
32curcumin448.3MYC, HMOX1, MAPK3, CASP3, MAPK1, RPS27A
33glutamine448.3HRAS, MAPT, HSPB2, PRDX5, RPS27A, SNCA
34arginine448.2SNCA, RPS27A, MAPK3, HMOX1, HRAS, HSPB2
35cycloheximide448.2MAPT, MAPK1, RPS27A, MYC, CSF3, CASP3
36nitric oxide44 24 1110.2MAPK3, HRAS, MAPK1, SNCA, HCRT, PRDX5
37doxorubicin44 50 1110.2HSPB2, MYC, HRAS, HMOX1, CASP3, MAPT
384-hydroxynonenal44 249.1MAPK1, SNCA, MYC, PRDX5, RPS27A, HMOX1
39cyclosporin a44 28 6110.1MYC, PRDX5, RPS27A, MAPT, HRAS, HMOX1
40cysteine448.0GBA, MAPT, PRDX5, SNCA, HRAS, RPS27A
41estrogen448.0HRAS, MAPK3, MYC, PRDX5, RPS27A, MAPK1
42n acetylcysteine447.8HMOX1, CASP3, MAPK3, MAPK1, RPS27A, SNCA
43oxygen44 248.8SNCA, PRDX5, GBA, HSPB2, HMOX1, HRAS
44vegf447.6MAPK1, MAPK3, CSF3, CASP3, HMOX1, RPS27A
45h2o2447.4RPS27A, MAPK1, MAPK3, HMOX1, HRAS, SNCA
46retinoic acid44 248.3MAPK3, CASP3, HMOX1, MYC, PRDX5, RPS27A
47tyrosine447.3CSF3, MAPK3, HRAS, MAPK1, RPS27A, SNCA
48superoxide44 248.2HMOX1, HSPB2, HRAS, TARDBP, CASP3, CSF3
49serine447.1MAPK3, CASP3, MAPT, HRAS, MAPK1, RPS27A
50cisplatin44 50 61 1110.0HSPB2, MYC, CSF3, HMOX1, PRDX5, CASP3

GO Terms for genes affiliated with Corticobasal Degeneration

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Cellular components related to Corticobasal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pseudopodiumGO:0311439.8MAPK3, MAPK1
2caveolaGO:0059019.2HMOX1, MAPK3, MAPK1
3cytosolGO:0058296.7HRAS, HSPB2, PGAM1, PRDX5, SNCA, RPS27A
4nucleusGO:0056345.4PRDX5, MYC, HSPB2, CFL1, PITX3, SNCA

Biological processes related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1regulation of early endosome to late endosome transportGO:200064110.2MAPK1, MAPK3
2regulation of Golgi inheritanceGO:09017010.2MAPK1, MAPK3
3response to epidermal growth factorGO:07084910.2MAPK3, MAPK1
4caveolin-mediated endocytosisGO:07258410.2MAPK3, MAPK1
5regulation of stress-activated MAPK cascadeGO:03287210.1MAPK3, MAPK1
6regulation of long-term neuronal synaptic plasticityGO:04816910.0HRAS, SNCA
7response to estrogenGO:0436279.9GBA, MAPK1, HMOX1
8stress-activated MAPK cascadeGO:0514039.9MAPK3, MAPK1, RPS27A
9regulation of cytoskeleton organizationGO:0514939.9MAPK3, MAPK1
10toll-like receptor 10 signaling pathwayGO:0341669.9RPS27A, MAPK1, MAPK3
11toll-like receptor 5 signaling pathwayGO:0341469.9RPS27A, MAPK1, MAPK3
12positive regulation of actin cytoskeleton reorganizationGO:20002519.9HRAS, CSF3
13toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.9RPS27A, MAPK1, MAPK3
14toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.9RPS27A, MAPK1, MAPK3
15regulation of sequence-specific DNA binding transcription factor activityGO:0510909.9HMOX1, MAPK3, MAPK1
16activation of MAPKK activityGO:0001869.9HRAS, MAPK3, MAPK1
17toll-like receptor 9 signaling pathwayGO:0341629.9RPS27A, MAPK1, MAPK3
18toll-like receptor 2 signaling pathwayGO:0341349.9MAPK3, MAPK1, RPS27A
19TRIF-dependent toll-like receptor signaling pathwayGO:0356669.9MAPK3, MAPK1, RPS27A
20MyD88-independent toll-like receptor signaling pathwayGO:0027569.9RPS27A, MAPK1, MAPK3
21MyD88-dependent toll-like receptor signaling pathwayGO:0027559.9RPS27A, MAPK1, MAPK3
22toll-like receptor 3 signaling pathwayGO:0341389.9MAPK3, MAPK1, RPS27A
23Ras protein signal transductionGO:0072659.9MAPK1, MAPK3, HRAS
24activation of MAPK activityGO:0001879.8RPS27A, MAPK1, MAPK3
25toll-like receptor 4 signaling pathwayGO:0341429.8RPS27A, MAPK1, MAPK3
26negative regulation of neuron apoptotic processGO:0435249.8HRAS, HMOX1, SNCA
27JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8MAPK3, MAPK1
28toll-like receptor signaling pathwayGO:0022249.8RPS27A, MAPK1, MAPK3
29fibroblast growth factor receptor signaling pathwayGO:0085439.7RPS27A, MAPK1, MAPK3, HRAS
30Fc-epsilon receptor signaling pathwayGO:0380959.7RPS27A, MAPK1, MAPK3, HRAS
31epidermal growth factor receptor signaling pathwayGO:0071739.7HRAS, MAPK3, MAPK1, RPS27A
32regulation of excitatory postsynaptic membrane potentialGO:0600799.6SNCA, HCRT
33insulin receptor signaling pathwayGO:0082869.6HRAS, MAPK3, MAPK1
34MAPK cascadeGO:0001659.6HRAS, MAPK3, MAPK1, MYC
35small GTPase mediated signal transductionGO:0072649.5HRAS, HMOX1, MAPK3, MAPK1
36organ morphogenesisGO:0098879.5HRAS, MAPK3, MAPK1, PITX3
37apoptotic processGO:0069159.3RPS27A, MAPK1, MAPT, MAPK3, CASP3
38neurotrophin TRK receptor signaling pathwayGO:0480119.3RPS27A, MAPK1, MAPK3, CASP3, HRAS
39Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.3MAPK3, MAPK1, CFL1
40cellular response to DNA damage stimulusGO:0069749.2CASP3, MAPK1, MYC
41positive regulation of cell proliferationGO:0082849.1MYC, MAPK1, CSF3, HRAS
42positive regulation of transcription from RNA polymerase II promoterGO:0459449.1MYC, RPS27A, MAPK3, CSF3, HRAS
43axon guidanceGO:0074118.9HRAS, MAPK3, MAPK1, CFL1
44innate immune responseGO:0450878.8CFL1, RPS27A, MAPK1, MAPK3, HRAS
45blood coagulationGO:0075968.7CFL1, MAPK1, MAPK3, HRAS
46negative regulation of apoptotic processGO:0430668.2CFL1, MYC, PRDX5, SNCA, RPS27A, CASP3

Molecular functions related to Corticobasal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase activityGO:0047079.7MAPK1, MAPK3
2cysteine-type endopeptidase inhibitor activity involved in apoptotic processGO:0430279.5SNCA, PRDX5
3phosphotyrosine bindingGO:0017849.5MAPK3, MAPK1
4protein bindingGO:0055156.2HRAS, GBA, CFL1, HSPB2, PGAM1, MYC

Products for genes affiliated with Corticobasal Degeneration

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Sources for Corticobasal Degeneration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet