Corticobasal Degeneration disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Corticobasal Degeneration

Sources:
⁴²NIH Rare Diseases, ⁴³NINDS, ⁶³Wikipedia, ³²MalaCards
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NINDS:⁴³ Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to progressive supranuclear palsy and dementia. An important gene associated with Corticobasal Degeneration is MAPT (microtubule-associated protein tau), and among its related pathways are Nongenotropic Androgen signaling and SHC1 events in ERBB2 signaling. The compounds cycloheximide and butyrate have been mentioned in the context of this disorder. Affiliated tissues include cortex and brain, and related mouse phenotypes are taste/olfaction and renal/urinary system.

NIH Rare Diseases:⁴² Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/4/2010

Wikipedia:⁶³ Corticobasal degeneration (CBD) or Corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

Aliases & Classifications for Corticobasal Degeneration

Sources:
⁴²NIH Rare Diseases, ⁴³NINDS, ⁴⁸Orphanet, ⁶⁰UMLS, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ⁶¹UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases

ICD10: ²⁶

Diseases of the nervous system

Other degenerative diseases of the nervous system

Other degenerative diseases of nervous system, not elsewhere classified

Circumscribed brain atrophy

Characteristics (Orphanet epidemiological data):

⁴⁸

corticobasal degeneration:
Prevalence: 1-9/100000; Age of onset: Adulthood

Aliases & Descriptions:

corticobasal degeneration ⁴² ⁴³ ⁴⁸ ⁶⁰

cortical-basal ganglionic degeneration ⁴²

cortico-basal ganglionic degeneration ⁴²

cbgd ⁴²

External Ids:

ICD10 via Orphanet²⁶ G31.0

SNOMED-CT via Orphanet⁵⁷ 18842008

UMLS via Orphanet⁶¹ C0393570

Related Diseases for Corticobasal Degeneration

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Corticobasal Degeneration family:

Corticobasal Degeneration, Mapt-Related

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 136)

id	Related Disease	Score	Top Affiliating Genes
1	progressive supranuclear palsy	31.6	RPS27A, SNCA, HCRT, MAPT
2	dementia	31.1	HCRT, TARDBP, GBA, MAPK3, SNCA, RPS27A
3	frontotemporal dementia	31.0	TARDBP, SNCA, MAPT, RPS27A
4	alzheimer's disease	31.0	MAPK1, HCRT, TARDBP, HRAS, HMOX1, MAPK3
5	pick's disease	31.0	RPS27A, SNCA, MAPT, TARDBP
6	aphasia	31.0	MAPT, TARDBP
7	parkinson's disease	30.8	MAPK3, SNCA, RPS27A, CASP3, GBA, MAPT
8	tauopathy	30.8	MAPT, RPS27A, SNCA
9	multiple system atrophy	30.7	SNCA, MAPT, RPS27A
10	brain disease	30.6	HCRT, MAPT, SNCA
11	lewy body dementia	30.5	RPS27A, SNCA, MAPT
12	motor neuron disease	30.4	RPS27A, SNCA, MAPT, TARDBP
13	rem sleep behavior disorder	30.3	SNCA
14	lateral sclerosis	30.3	MAPT, SNCA
15	amyotrophic lateral sclerosis	30.3	TARDBP, MAPT, SNCA, CASP3, HSPB2, RPS27A
16	huntington's disease	30.1	CASP3
17	pulmonary fibrosis	30.1	HMOX1
18	creutzfeldt-jakob syndrome	30.1	RPS27A, SNCA, MAPT
19	striatonigral degeneration	30.1	SNCA, RPS27A
20	movement disease	30.1	MAPT, RPS27A, SNCA
21	apraxia	10.8
22	cerebritis	10.7
23	cerebral degeneration	10.7
24	neuronitis	10.6
25	cerebral palsy	10.4
26	basal ganglia disease	10.2
27	sleep disorder	10.2
28	corticobasal degeneration, mapt-related	10.2
29	parametritis	10.1
30	antiphospholipid syndrome	10.1
31	olivopontocerebellar atrophy	10.1
32	arachnoiditis	10.1
33	ideomotor apraxia	10.1
34	complex regional pain syndrome	10.1
35	image syndrome	10.1
36	hereditary diffuse leukoencephalopathy with spheroids	10.1
37	multiple sclerosis	10.0	HCRT
38	endometriosis	10.0	RPS27A
39	neuronal intranuclear inclusion disease	10.0	RPS27A
40	pancreatitis	10.0	HRAS
41	bladder carcinoma	10.0	HRAS
42	cerebral amyloid angiopathy	10.0	MAPT
43	tuberculosis	10.0	PRDX5
44	hepatitis b	10.0	HRAS
45	cystic fibrosis	10.0	HMOX1
46	neuroblastoma	10.0	MYC
47	transient cerebral ischemia	10.0	RPS27A
48	myopathy	10.0	HSPB2, RPS27A
49	semantic dementia	10.0	MAPT, RPS27A
50	brain ischemia	10.0	MAPK3, MAPT

Graphical network of the top 20 diseases related to Corticobasal Degeneration:

Clinical Features for Corticobasal Degeneration

Drugs & Therapeutics for Corticobasal Degeneration

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Corticobasal Degeneration

Drug clinical trials:

Search ClinicalTrials for Corticobasal Degeneration

Search NIH Clinical Center for Corticobasal Degeneration

Search CenterWatch for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

Anatomical Context for Corticobasal Degeneration

Sources:
³²MalaCards
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MalaCards organs/tissues related to Corticobasal Degeneration:

³²

Cortex, Brain

Animal Models for Corticobasal Degeneration or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Corticobasal Degeneration:

³⁶ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	10.2	SNCA
2	renal/urinary system phenotype	MP:0005367	9.0	CFL1, SNCA, HMOX1
3	integument phenotype	MP:0010771	9.0	CASP3, MAPT, MYC, GBA, HRAS
4	respiratory system phenotype	MP:0005388	8.6	HCRT, MAPK3, CASP3, GBA, MAPK1
5	no phenotypic analysis	MP:0003012	8.3	SNCA, CFL1, HRAS, TARDBP, MYC, MAPT
6	muscle phenotype	MP:0005369	8.1	HSPB2, CASP3, MAPK3, MAPT, MAPK1, MYC
7	homeostasis/metabolism phenotype	MP:0005376	8.0	TARDBP, GBA, HMOX1, MAPK3, SNCA, CFL1
8	hematopoietic system phenotype	MP:0005397	7.3	GBA, MAPT, CASP3, CSF3, MAPK3, MAPK1
9	nervous system phenotype	MP:0003631	7.3	HSPB2, MAPT, MAPK1, MYC, HCRT, HRAS
10	immune system phenotype	MP:0005387	6.9	HSPB2, CASP3, MYC, GBA, MAPK1, MAPT
11	cardiovascular system phenotype	MP:0005385	6.4	HSPB2, SNCA, MAPK3, MAPK1, HCRT, MYC
12	cellular phenotype	MP:0005384	6.4	HSPB2, SNCA, CASP3, MAPK3, MAPT, MAPK1
13	mortality/aging	MP:0010768	6.1	MYC, HSPB2, CASP3, HMOX1, SNCA, GBA
14	behavior/neurological phenotype	MP:0005386	6.0	CASP3, HSPB2, SNCA, MAPK3, MAPT, MAPK1
15	growth/size phenotype	MP:0005378	6.0	HSPB2, CASP3, SNCA, MAPK3, MAPT, MAPK1

Publications for Corticobasal Degeneration

Genes related to Corticobasal Degeneration

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Corticobasal Degeneration:

(show all 18)

id	Symbol	Description	Score	Implication
1	MAPT	microtubule-associated protein tau	20.55	GeneCards inferred : Publications, Disorders (show sections)
2	HCRT	hypocretin (orexin) neuropeptide precursor	19.44	GeneCards inferred : Publications, Disorders (show sections)
3	KPRP	keratinocyte proline-rich protein	18.33	GeneCards inferred : Disorders (show sections)
4	PGAM1	phosphoglycerate mutase 1 (brain)	17.22	GeneCards inferred : Publications, Disorders (show sections)
5	RPS27A	ribosomal protein S27a	16.11	GeneCards inferred : Publications, Disorders (show sections)
6	HRAS	Harvey rat sarcoma viral oncogene homolog	15.00	GeneCards inferred : Publications, Disorders (show sections)
7	TARDBP	TAR DNA binding protein	13.89	GeneCards inferred : Publications, Disorders (show sections)
8	MAPK3	mitogen-activated protein kinase 3	12.77	GeneCards inferred : Publications, Disorders (show sections)
9	HMOX1	heme oxygenase (decycling) 1	11.66	GeneCards inferred : Publications, Disorders (show sections)
10	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	10.55	GeneCards inferred : Publications, Disorders (show sections)
11	MYC	v-myc avian myelocytomatosis viral oncogene homolog	9.44	GeneCards inferred : Publications, Disorders (show sections)
12	CASP3	caspase 3, apoptosis-related cysteine peptidase	8.33	GeneCards inferred : Publications, Disorders (show sections)
13	MAPK1	mitogen-activated protein kinase 1	7.22	GeneCards inferred : Publications, Disorders (show sections)
14	GBA	glucosidase, beta, acid	5.56	GeneCards inferred : Publications (show sections)
15	HSPB2	heat shock 27kDa protein 2	5.00	GeneCards inferred : Publications, Disorders (show sections)
16	PRDX5	peroxiredoxin 5	3.89	GeneCards inferred : Publications, Disorders (show sections)
17	CFL1	cofilin 1 (non-muscle)	2.77	GeneCards inferred : Publications, Disorders (show sections)
18	CSF3	colony stimulating factor 3 (granulocyte)	1.66	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Corticobasal Degeneration disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	17	17	18
2	LSBio	-	-	18

Genetic Variations for Corticobasal Degeneration

Expression for genes affiliated with Corticobasal Degeneration

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for genes affiliated with Corticobasal Degeneration

Sources:
³⁷NCBI BioSystems Database, ⁵³Reactome, ¹²EMD Millipore, ⁵¹QIAGEN, ²⁹KEGG, ⁴⁹PharmGKB, ⁵⁹Tocris Bioscience
See all sources

Pathways related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50) (show all 125)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Nongenotropic Androgen signaling³⁷	9.5	MAPK1, HRAS, MAPK3
2	SHC1 events in ERBB2 signaling⁵³ Hide members GRB2 events in ERBB2 signaling⁵³ SHC1 events in ERBB4 signaling⁵³	9.5	MAPK1, HRAS, MAPK3
3	ARMS-mediated activation⁵³ Hide members Prolonged ERK activation events⁵³ Signalling to p38 via RIT and RIN⁵³ Frs2-mediated activation⁵³	9.5	MAPK3, HRAS, MAPK1
4	Development Leptin signaling via JAK/STAT and MAPK cascades Hide members Development Leptin signaling via JAK/STAT and MAPK cascades¹²	9.5	HRAS, MAPK3, MAPK1
5	Immune response IL-6 signaling pathway Hide members Immune response IL-6 signaling pathway¹²	9.5	MAPK3, MAPK1, HRAS
6	MNAR-PELP1 and Estrogen Receptor Interaction⁵¹	9.5	MAPK3, MAPK1, HRAS
7	Alpha-synuclein signaling³⁷	9.5	MAPK1, MAPK3, SNCA
8	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2 Hide members Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2¹²	9.4	MYC, MAPK1, MAPK3
9	SHC-mediated signalling⁵³ Hide members Signaling by constitutively active EGFR⁵³ RAF phosphorylates MEK⁵³ EGFR Transactivation by Gastrin⁵³ MEK activation⁵³ GRB2 events in EGFR signaling⁵³ RAF activation⁵³ SHC1 events in EGFR signaling⁵³ SHC-related events⁵³ SOS-mediated signalling⁵³ RAF/MAP kinase cascade⁵³ Activation of RAS in B Cells⁵³ SHC-related events triggered by IGF1R⁵³	9.3	MAPK3, RPS27A, HRAS, MAPK1
10	Interleukin-3, 5 and GM-CSF signaling⁵³ Hide members Signaling by Interleukins⁵³ Interleukin-2 signaling⁵³ Interleukin receptor SHC signaling⁵³ Signaling by Interleukins⁵³ Regulation of signaling by CBL⁵³	9.3	RPS27A, HRAS, MAPK1, MAPK3
11	Development A3 receptor signaling Hide members Development A3 receptor signaling¹² G-protein signaling G-Protein alpha-q signaling cascades¹² Development A1 receptor signaling¹²	9.2	MYC, MAPK1, MAPK3, HRAS
12	Immune response IL-2 activation and signaling pathway Hide members Immune response IL-2 activation and signaling pathway¹² Immune response IL-3 activation and signaling pathway¹²	9.2	MYC, MAPK1, MAPK3, HRAS
13	Chronic myeloid leukemia²⁹ Hide members Pancreatic cancer²⁹	9.2	HRAS, MYC, MAPK3, MAPK1
14	Development IGF-RI signaling¹² Hide members Signal transduction AKT signaling¹²	9.2	MYC, MAPK1, HRAS, MAPK3
15	Thyroid cancer²⁹	9.2	HRAS, MYC, MAPK1, MAPK3
16	Development PDGF signaling via STATs and NF-kB Hide members Development PDGF signaling via STATs and NF-kB¹² Angiopoietin receptor Tie2-mediated signaling³⁷	9.2	MYC, MAPK3, MAPK1, HRAS
17	ErbB signaling pathway²⁹ Hide members ErbB signaling pathway³⁷ EGFR Inhibitor Pathway, Pharmacodynamics⁴⁹	9.2	HRAS, MAPK1, MYC, MAPK3
18	Glioblastoma Multiforme⁵¹	9.2	MAPK3, MAPK1, MYC, HRAS
19	TSH signaling pathway³⁷	9.2	MAPK3, MAPK1, MYC, HRAS
20	Development EPO-induced Jak-STAT pathway Hide members Development EPO-induced Jak-STAT pathway¹² EPO signaling pathway³⁷ EPO Receptor Signaling³⁷	9.2	MAPK1, MAPK3, HRAS, MYC
21	Syndecan-2-mediated signaling events³⁷	9.2	MAPK1, CASP3, MAPK3, HRAS
22	G-protein signaling Ras family GTPases in kinase cascades (scheme) Hide members G-protein signaling Ras family GTPases in kinase cascades (scheme)¹² MAPK Cascade³⁷ Immune response Oncostatin M signaling via MAPK in human cells¹² Oncostatin M Signaling Pathway³⁷ Activation of the AP-1 family of transcription factors⁵³	9.2	HRAS, MAPK1, MAPK3, CASP3
23	UVA-Induced MAPK Signaling⁵¹ Hide members UVB-Induced MAPK Signaling⁵¹	9.2	HRAS, MAPK1, MAPK3, CASP3
24	TNF-Induced Apoptosis Implicating Sphingolipids⁵¹ Hide members Ceramide Pathway⁵¹	9.2	CASP3, MAPK3, MAPK1, HRAS
25	Spinal Cord Injury³⁷	9.1	MAPK3, MYC, CASP3, MAPK1
26	IL-2 Signaling pathway³⁷ Hide members IL2-mediated signaling events³⁷	9.0	HRAS, MAPT, MYC, MAPK1, MAPK3
27	Semaphorin Signaling⁵¹	9.0	MAPK1, MAPK3, CFL1
28	IL-6 Signaling Pathway³⁷	9.0	MAPK3, MAPK1, MAPT, CASP3, HRAS
29	EGFR1 Signaling Pathway³⁷	8.9	HRAS, MAPK1, SNCA, MAPK3, MYC
30	Integrated Pancreatic Cancer Pathway³⁷	8.9	CASP3, MAPK3, MAPT, MYC, MAPK1
31	Pathways in cancer²⁹	8.8	HRAS, MYC, MAPK1, MAPK3, CASP3
32	Development Prolactin receptor signaling Hide members Prolactin Signaling Pathway³⁷ Development Prolactin receptor signaling¹² Prolactin signaling pathway²⁹ Leptin signaling pathway³⁷	8.8	MAPK1, CASP3, HRAS, MYC, MAPK3
33	Sorafenib Pharmacodynamics⁴⁹ Hide members VEGF Pathway⁵⁹ Vemurafenib Pathway, Pharmacodynamics⁴⁹	8.8	MYC, CASP3, MAPK3, MAPK1, HRAS
34	Toll-like receptor signaling pathway³⁷ Hide members Hepatitis B²⁹ Chagas disease (American trypanosomiasis)²⁹ Toll-like receptor signaling pathway²⁹	8.8	CASP3, MAPK1, MYC, HRAS, MAPK3
35	Prostate Cancer³⁷ Hide members Integrated Cancer pathway³⁷	8.8	HRAS, MYC, MAPK3, CASP3, MAPK1
36	TRKA Signaling⁵¹ Hide members NGF Pathway⁵¹	8.8	MAPK3, MAPK1, MYC, HRAS, CASP3
37	Development HGF signaling pathway¹² Hide members Development PDGF signaling via MAPK cascades¹² Signaling of Hepatocyte Growth Factor Receptor³⁷ Neurotrophin signaling pathway²⁹ Development EGFR signaling via small GTPases¹² Renal cell carcinoma²⁹ Development Neurotrophin family signaling¹² Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)³⁷ Apoptosis and survival NGF signaling pathway¹² Apoptosis and survival Role of CDK5 in neuronal death and survival¹² Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1¹²	8.8	CASP3, MYC, MAPK1, HRAS, MAPK3
38	Endometrial cancer²⁹ Hide members Acute myeloid leukemia²⁹ Signal transduction PTEN pathway¹² Colorectal cancer²⁹	8.8	MAPK1, CASP3, MYC, HRAS, MAPK3
39	MicroRNAs in cancer²⁹	8.8	MAPK1, MYC, HRAS, HMOX1, CASP3
40	CDC42 signaling events³⁷ Hide members RAC1 signaling pathway³⁷	8.7	CFL1, HRAS, MAPK1, MAPK3
41	Axon guidance²⁹	8.7	HRAS, MAPK1, CFL1, MAPK3
42	Nanog in Mammalian ESC Pluripotency⁵¹ Hide members GSK3 Signaling⁵¹ 14-3-3 Induced Intracellular Signaling⁵¹ eNOS Signaling⁵¹	8.6	MAPK1, HRAS, CASP3, MAPK3, SNCA, MAPT
43	Pertussis²⁹	8.6	CFL1, MAPK1, MAPK3, CASP3
44	fMLP Pathway⁵¹ Hide members CCR3 Pathway in Eosinophils⁵¹ Internalin Pathway⁵¹ CXCR4 Pathway⁵¹ Alpha-Adrenergic Signaling⁵¹ VEGF and S-1P Signaling⁵¹ Signal transduction Activation of PKC via G-Protein coupled receptor¹² Huntingtons Disease Pathway⁵¹	8.3	MAPK1, HRAS, CASP3, MAPK3, CFL1
45	Proteoglycans in cancer²⁹	8.3	MYC, HSPB2, CASP3, MAPK3, MAPK1, HRAS
46	BDNF signaling pathway³⁷	8.1	CASP3, MAPT, MAPK1, HRAS, CFL1, MAPK3
47	MAPK signaling pathway³⁷ Hide members MAPK signaling pathway²⁹	8.1	MAPK3, HRAS, MYC, HSPB2, CASP3, MAPK1
48	Integrin Pathway⁵¹ Hide members Transendothelial Migration of Leukocytes⁵¹ FAK1 Signaling⁵¹ GnRH Signaling⁵¹ UPA-UPAR Pathway⁵¹ Inhibition of Angiogenesis by TSP1⁵¹	8.0	MAPK1, CASP3, MYC, MAPK3, CFL1, HRAS
49	PAK Pathway⁵¹ Hide members Epithelial Adherens Junctions⁵¹ Antioxidant Action of Vitamin-C⁵¹	7.8	CFL1, MAPK3, CSF3, MAPK1, CASP3, HRAS
50	Apoptotic Pathways in Synovial Fibroblasts⁵¹ Hide members Actin-Based Motility by Rho Family GTPases⁵¹ Rac1 Pathway⁵¹ PPAR Pathway⁵¹ Glioma Invasiveness⁵¹ eIF2 Pathway⁵¹ ERK5 Signaling⁵¹ Rap1 Pathway⁵¹ Telomerase Components in Cell Signaling⁵¹ DHA Signaling⁵¹ Cellular Apoptosis Pathway⁵¹ p53 Mediated Apoptosis⁵¹ Mitochondrial Apoptosis⁵¹	7.8	CASP3, MAPK1, MAPK3, MYC, HRAS, CFL1

Compounds for genes affiliated with Corticobasal Degeneration

Sources:
⁴⁴Novoseek, ⁵⁹Tocris Bioscience, ²⁸IUPHAR, ¹¹DrugBank, ²⁴HMDB, ⁴⁹PharmGKB, ²BitterDB
See all sources

Compounds related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50) (show all 124)

id	Compound	Score	Top Affiliating Genes
1	cycloheximide⁴⁴	10.7	MAPT
2	butyrate⁴⁴	10.4	RPS27A, MAPT
3	thioflavine s⁴⁴	10.1	RPS27A, SNCA, MAPT
4	rotenone⁴⁴	10.0	SNCA, HMOX1, RPS27A
5	pge2⁴⁴	9.9	HRAS, SNCA
6	thapsigargin⁴⁴ ⁵⁹	10.8	MAPK3, CASP3, HCRT
7	nmda⁴⁴ ²⁸	10.6	RPS27A, MAPK3, MAPT, HCRT, HRAS
8	resveratrol⁴⁴ ⁵⁹ ¹¹ ²⁴	12.6	MAPK3, HMOX1, PRDX5
9	formate⁴⁴	9.5	SNCA, RPS27A, MAPT, PRDX5
10	radicicol⁴⁴ ⁵⁹ ¹¹	11.4	HSPB2, MAPK3, RPS27A, MAPK1
11	c2ceramide⁴⁴	9.4	MAPK3, MAPT, MAPK1, CASP3
12	6-hydroxydopamine⁴⁴	9.3	SNCA, MYC, CASP3, RPS27A, HMOX1
13	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.3	MYC, MAPK1, MAPK3, HCRT
14	roscovitine⁴⁴	9.3	MAPT, MAPK1, CASP3, MYC, MAPK3
15	herbimycin a⁴⁴ ⁵⁹	10.3	MAPK1, HRAS, MYC, MAPK3, RPS27A
16	rottlerin⁴⁴	9.2	MAPK1, HMOX1, MAPK3, CASP3
17	ly294002⁴⁴	9.2	MAPK3, MYC, HMOX1, MAPK1, HRAS
18	sp 600125⁴⁴ ⁵⁹	10.2	CASP3, SNCA, MAPK3, HMOX1, MAPK1
19	valine⁴⁴	9.2	SNCA, RPS27A, MAPT, HRAS, CSF3
20	serine⁴⁴	9.1	MAPT, HRAS, SNCA, GBA, HSPB2
21	sulforaphane⁴⁴	9.1	HMOX1, PRDX5, CASP3, MAPK1
22	acetylcholine⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	13.0	HCRT, MAPT, HMOX1, SNCA, HSPB2, RPS27A
23	15-deoxy-delta-12,14-prostaglandin j2⁴⁴	8.9	CASP3, MAPK1, HMOX1, MYC
24	quercetin⁴⁴ ⁵⁹ ¹¹ ²⁴	11.9	HSPB2, CASP3, MAPK3, HMOX1, MAPK1
25	melphalan⁴⁴ ¹¹	9.9	MAPK3, PRDX5, MYC, CSF3
26	actinomycin d⁴⁴	8.9	MAPK1, HMOX1, MYC, CASP3, RPS27A, MAPT
27	imatinib⁴⁴ ⁴⁹ ¹¹	10.9	MYC, MAPK1, CSF3, CASP3, RPS27A
28	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	13.8	CASP3, MAPK3, MAPK1, HRAS, MYC, MAPT
29	lactacystin⁴⁴	8.7	RPS27A, CASP3, MAPK1, SNCA, MAPT, MYC
30	mg 132⁴⁴ ⁵⁹	9.7	RPS27A, CASP3, MAPT, MAPK1, MYC, HMOX1
31	paclitaxel⁴⁴ ⁴⁹ ¹¹	10.7	MAPK1, CASP3, MAPK3, MYC, HRAS, CSF3
32	daunorubicin⁴⁴ ⁴⁹ ¹¹	10.7	MAPK3, CSF3, CASP3, MYC
33	rapamycin⁴⁴	8.6	SNCA, HRAS, MYC, MAPK1, CASP3, RPS27A
34	sb 203580⁴⁴ ⁵⁹	9.6	HMOX1, SNCA, MAPK1, MAPK3, CASP3, HSPB2
35	pd 98,059⁴⁴	8.6	MAPK3, CASP3, HSPB2, MAPK1, HRAS, MYC
36	arsenite⁴⁴ ²⁴	9.4	HMOX1, MYC, MAPK3, CASP3, HSPB2, RPS27A
37	curcumin⁴⁴	8.3	PRDX5, MYC, MAPK1, MAPK3, CASP3, RPS27A
38	glutamine⁴⁴	8.3	RPS27A, HSPB2, SNCA, PRDX5, MAPT, HRAS
39	oxygen⁴⁴ ²⁴	9.3	HSPB2, HMOX1, HRAS, GBA, PRDX5, SNCA
40	doxorubicin⁴⁴ ⁴⁹ ¹¹	10.1	RPS27A, CSF3, MAPT, MYC, HRAS, HMOX1
41	4-hydroxynonenal⁴⁴ ²⁴	9.1	MAPT, RPS27A, MYC, MAPK1, PRDX5, SNCA
42	cyclosporin a⁴⁴ ²⁸ ⁵⁹	10.0	RPS27A, MYC, HRAS, CASP3, CSF3, PRDX5
43	nitric oxide⁴⁴ ¹¹ ²⁴	10.0	SNCA, HRAS, GBA, MAPK1, MAPK3, PRDX5
44	n acetylcysteine⁴⁴	7.8	MAPT, PRDX5, HMOX1, MAPK3, SNCA, CASP3
45	cysteine⁴⁴	7.8	HMOX1, GBA, MAPT, RPS27A, MAPK3, PRDX5
46	vegf⁴⁴	7.6	HSPB2, HRAS, MYC, MAPK1, CSF3, MAPK3
47	superoxide⁴⁴ ²⁴	8.5	HSPB2, CSF3, PRDX5, TARDBP, CASP3, CFL1
48	h2o2⁴⁴	7.4	HRAS, MAPT, MAPK3, RPS27A, HSPB2, SNCA
49	retinoic acid⁴⁴ ²⁴	8.3	HMOX1, MAPK3, RPS27A, CSF3, PRDX5, MAPT
50	cisplatin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	10.0	HSPB2, RPS27A, PRDX5, MAPK3, MAPK1, HMOX1

GO Terms for genes affiliated with Corticobasal Degeneration

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Corticobasal Degeneration according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	pseudopodium	GO:031143	9.8	MAPK1, MAPK3
2	caveola	GO:005901	9.4	HMOX1, MAPK1, MAPK3
3	cytosol	GO:005829	6.7	PGAM1, HRAS, HMOX1, MAPT, MAPK3, PRDX5
4	nucleus	GO:005634	5.7	CFL1, HMOX1, HRAS, TARDBP, MYC, MAPK1

Biological processes related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show all 38)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of Golgi inheritance	GO:090170	10.2	MAPK1, MAPK3
2	regulation of early endosome to late endosome transport	GO:2000641	10.2	MAPK1, MAPK3
3	caveolin-mediated endocytosis	GO:072584	10.2	MAPK3, MAPK1
4	response to epidermal growth factor stimulus	GO:070849	10.2	MAPK3, MAPK1
5	regulation of stress-activated MAPK cascade	GO:032872	10.1	MAPK1, MAPK3
6	positive regulation of actin cytoskeleton reorganization	GO:2000251	10.0	HRAS, CSF3
7	activation of MAPKK activity	GO:000186	9.9	MAPK3, MAPK1, HRAS
8	stress-activated MAPK cascade	GO:051403	9.9	RPS27A, MAPK3, MAPK1
9	toll-like receptor 10 signaling pathway	GO:034166	9.9	RPS27A, MAPK3, MAPK1
10	toll-like receptor 5 signaling pathway	GO:034146	9.9	RPS27A, MAPK3, MAPK1
11	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.9	MAPK3, MAPK1, HMOX1
12	toll-like receptor TLR6:TLR2 signaling pathway	GO:038124	9.9	RPS27A, MAPK3, MAPK1
13	toll-like receptor TLR1:TLR2 signaling pathway	GO:038123	9.9	RPS27A, MAPK3, MAPK1
14	toll-like receptor 9 signaling pathway	GO:034162	9.9	RPS27A, MAPK3, MAPK1
15	toll-like receptor 2 signaling pathway	GO:034134	9.9	RPS27A, MAPK3, MAPK1
16	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.8	RPS27A, MAPK3, MAPK1
17	Ras protein signal transduction	GO:007265	9.8	MAPK3, MAPK1, HRAS
18	MyD88-independent toll-like receptor signaling pathway	GO:002756	9.8	MAPK1, MAPK3, RPS27A
19	toll-like receptor 3 signaling pathway	GO:034138	9.8	RPS27A, MAPK3, MAPK1
20	MyD88-dependent toll-like receptor signaling pathway	GO:002755	9.8	RPS27A, MAPK3, MAPK1
21	regulation of cytoskeleton organization	GO:051493	9.8	MAPK1, MAPK3
22	organ morphogenesis	GO:009887	9.8	MAPK3, MAPK1, HRAS
23	activation of MAPK activity	GO:000187	9.7	RPS27A, MAPK3, MAPK1
24	fibroblast growth factor receptor signaling pathway	GO:008543	9.7	RPS27A, MAPK3, MAPK1, HRAS
25	toll-like receptor 4 signaling pathway	GO:034142	9.7	RPS27A, MAPK3, MAPK1
26	Fc-epsilon receptor signaling pathway	GO:038095	9.7	HRAS, MAPK1, MAPK3, RPS27A
27	negative regulation of neuron apoptotic process	GO:043524	9.7	SNCA, HRAS, HMOX1
28	epidermal growth factor receptor signaling pathway	GO:007173	9.7	HRAS, MAPK1, MAPK3, RPS27A
29	MAPK cascade	GO:000165	9.6	HRAS, MYC, MAPK1, MAPK3
30	response to DNA damage stimulus	GO:006974	9.5	MYC, MAPK1, MAPK3, CASP3
31	neurotrophin TRK receptor signaling pathway	GO:048011	9.3	HRAS, MAPK1, MAPK3, CASP3, RPS27A
32	toll-like receptor signaling pathway	GO:002224	9.2	MAPK1, MAPK3, RPS27A
33	Fc-gamma receptor signaling pathway involved in phagocytosis	GO:038096	9.2	CFL1, MAPK1, MAPK3
34	small GTPase mediated signal transduction	GO:007264	9.1	MAPK3, MAPK1, HRAS, HMOX1
35	apoptotic process	GO:006915	9.1	MAPK1, MAPT, MAPK3, CASP3, RPS27A
36	axon guidance	GO:007411	8.7	CFL1, HRAS, MAPK1, MAPK3
37	innate immune response	GO:045087	8.6	CFL1, HRAS, MAPK1, MAPK3, RPS27A
38	negative regulation of apoptotic process	GO:043066	8.2	RPS27A, CASP3, SNCA, PRDX5, MYC, CFL1

Molecular functions related to Corticobasal Degeneration according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	phosphotyrosine binding	GO:001784	9.8	MAPK1, MAPK3
2	MAP kinase activity	GO:004707	9.5	MAPK1, MAPK3

Products for genes affiliated with Corticobasal Degeneration

Antibodies
Proteins
Lysates

Antibodies

Sources for Corticobasal Degeneration

¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Expression Omnibus DataSets

¹⁶Gene Ontology

¹⁷GeneCards

¹⁸GeneDecks

¹⁹GeneReviews

²⁰GeneTests

²¹Genetics Home Reference

²²GTR

²³HGMD

²⁴HMDB

²⁵ICD10

²⁶ICD10 via Orphanet

²⁷ICD9CM

²⁸IUPHAR

²⁹KEGG

³⁰LifeMap Discovery™

³¹LifeSpan BioSciences, Inc.

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PharmGKB

⁵⁰PubMed

⁵¹QIAGEN

⁵²R&D Systems

⁵³Reactome

⁵⁴SABiosciences

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸Thomson Reuters

⁵⁹Tocris Bioscience

⁶⁰UMLS

⁶¹UMLS via Orphanet

⁶²UniProtKB/Swiss-Prot

⁶³Wikipedia

CBGD MCID: CRT033 MIFTS: 45	Corticobasal Degeneration (CBGD) malady Neuronal diseases category
18 genes, 2 tissues, 136 related diseases, clinical trials.

Corticobasal Degeneration (CBGD) malady