Corticobasal Degeneration (CBGD) malady

NINDS:⁴⁴ Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to progressive supranuclear palsy and frontotemporal dementia. An important gene associated with Corticobasal Degeneration is MAPT (microtubule-associated protein tau), and among its related pathways are Nongenotropic Androgen signaling and SHC1 events in ERBB2 signaling. The compounds cycloheximide and butyrate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are taste/olfaction and renal/urinary system.

NIH Rare Diseases:⁴³ Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/4/2010

Wikipedia:⁶⁴ Corticobasal degeneration (CBD) or Corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

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ICD10 via Orphanet26 G31.0 SNOMED-CT via Orphanet58 18842008

UMLS via Orphanet62 C0393570

Search GEO for disease gene expression data for Corticobasal Degeneration.