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CBGD
MCID: CRT033
MIFTS: 47

Corticobasal Degeneration (CBGD) malady

Categories: Rare diseases, Neuronal diseases, Genetic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Corticobasal Degeneration

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Aliases & Descriptions for Corticobasal Degeneration:

Name: Corticobasal Degeneration 50 51 69
Corticobasal Syndrome 50 56
Cortical-Basal Ganglionic Degeneration 50
Cortico-Basal Ganglionic Degeneration 50
Cbgd 50

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA454887
ICD10 via Orphanet 34 G31.0
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Summaries for Corticobasal Degeneration

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NIH Rare Diseases : 50 corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. treatment depends on the symptoms in each person. people with corticobasal degeneration usually do not survive beyond an average of 7 years after symptoms begin. aspiration pneumonia or other complications are usually the cause of death. last updated: 3/13/2017

MalaCards based summary : Corticobasal Degeneration, also known as corticobasal syndrome, is related to progressive supranuclear palsy-corticobasal syndrome and corticobasal degeneration, mapt-related. An important gene associated with Corticobasal Degeneration is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are NFAT and Cardiac Hypertrophy and Development Slit-Robo signaling. The drugs cadexomer iodine and Iodine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and eye, and related phenotypes are Decreased viability with paclitaxel and behavior/neurological

NINDS : 51 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and  (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination,  (an absence of movements),  (a resistance to imposed movement), (impaired balance); and limb  (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech,  (muscular jerks), and  (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

Wikipedia : 71 Corticobasal degeneration (CBD) or corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

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Related Diseases for Corticobasal Degeneration

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Diseases in the Corticobasal Degeneration family:

Corticobasal Degeneration, Mapt-Related

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 progressive supranuclear palsy-corticobasal syndrome 12.0
2 corticobasal degeneration, mapt-related 12.0
3 dementia, frontotemporal 11.4
4 pick disease 11.4
5 semantic dementia 11.2
6 leukoencephalopathy, diffuse hereditary, with spheroids 10.9
7 supranuclear palsy, progressive 10.9
8 frontotemporal lobar degeneration with ubiquitin-positive inclusions 10.9
9 apraxia 10.4
10 dementia 10.4
11 cerebritis 10.3
12 aphasia 10.3
13 myoclonus 10.2
14 neuronitis 10.2
15 deafness, autosomal recessive 101 10.2 CRYAB MAPT RPS27A
16 severe congenital nemaline myopathy 10.1 MAPT RPS27A TARDBP
17 multiple system atrophy 10.1
18 alzheimer disease 10.1
19 andersen syndrome 10.1 MAPT RPS27A TARDBP
20 hypoproteinemia, hypercatabolic 10.1 MAPT RPS27A TARDBP
21 creutzfeldt-jakob disease 10.1
22 gallbladder adenoma 10.0 GBA MAPT RPS27A
23 dystonia 10.0
24 plekhm1-related autosomal recessive osteopetrosis 10.0 GBA MAPT UCHL1
25 acne inversa, familial, 3 10.0 MAPT RPS27A TARDBP
26 coenzyme q10 deficiency, primary, 1 10.0 GBA MAPT RPS27A TARDBP
27 hemochromatosis, type 2a 9.9 GBA MAPT PITX3 RPS27A UCHL1
28 basal ganglia calcification 9.9
29 lateral sclerosis 9.9
30 rem sleep behavior disorder 9.9
31 arachnoid cysts 9.7
32 neurosyphilis 9.7
33 arachnoiditis 9.7
34 progressive non-fluent aphasia 9.7
35 parametritis 9.7
36 neuroleptic malignant syndrome 9.7
37 ataxia 9.7
38 olivopontocerebellar atrophy 9.7
39 cerebral atrophy 9.7
40 normal pressure hydrocephalus 9.7
41 encephalopathy 9.7
42 antiphospholipid syndrome 9.7
43 spasticity 9.7
44 complex regional pain syndrome 9.7
45 posterior cortical atrophy 9.7
46 stiff-person syndrome 9.7
47 striatonigral degeneration 9.7
48 hydrocephalus 9.7
49 pulmonary fibrosis 9.7
50 craniofacial and skeletal defects 7.8 CFL1 CRYAB CSF3 GBA HSPB2 KIF13B

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to Corticobasal Degeneration
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Symptoms & Phenotypes for Corticobasal Degeneration

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GenomeRNAi Phenotypes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 9.02 MTOR RPS6KB1
2 Decreased viability with paclitaxel GR00179-A-2 9.02 MTOR
3 Decreased viability with paclitaxel GR00179-A-3 9.02 MTOR RPS6KB1

MGI Mouse Phenotypes related to Corticobasal Degeneration:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.24 CFL1 CRYAB GBA HSPB2 MAPT MOBP
2 cellular MP:0005384 10.23 GBA HSPB2 MAPT MTOR PITX3 ROCK1
3 cardiovascular system MP:0005385 10.22 CFL1 GBA HSPB2 MAPT MTOR PITX3
4 growth/size/body region MP:0005378 10.17 TARDBP UCHL1 CFL1 GBA MAPT MTOR
5 homeostasis/metabolism MP:0005376 10.15 CFL1 GBA KIF13B MAPT MTOR PITX3
6 hematopoietic system MP:0005397 10.1 GBA MAPT MTOR PITX3 ROCK1 RPS6KB1
7 immune system MP:0005387 10.02 CSF3 GBA MAPT MTOR PITX3 ROCK1
8 integument MP:0010771 9.86 CFL1 CSF3 GBA MAPT PITX3 ROCK1
9 muscle MP:0005369 9.76 CRYAB MAPT MTOR ROCK1 ROCK2 RPS6KB1
10 nervous system MP:0003631 9.73 CFL1 GBA HSPB2 MAPT MOBP MTOR
11 no phenotypic analysis MP:0003012 9.17 CFL1 KIF13B MAPT MTOR PITX3 SOS1
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Drugs & Therapeutics for Corticobasal Degeneration

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Drugs for Corticobasal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 cadexomer iodine Phase 4
2
Iodine Phase 4 7553-56-2 807
3 Pharmaceutical Solutions Phase 4
4 Calamus Nutraceutical Phase 4
5 Micronutrients Phase 2, Phase 3
6 Trace Elements Phase 2, Phase 3
7 Ubiquinone Phase 2, Phase 3
8 Vitamins Phase 2, Phase 3
9
Coenzyme Q10 Experimental, Nutraceutical Phase 2, Phase 3 303-98-0 5281915
10 Antidepressive Agents Phase 1, Phase 2
11 Antimanic Agents Phase 1, Phase 2
12 Central Nervous System Depressants Phase 1, Phase 2
13 Lithium carbonate Phase 1, Phase 2 554-13-2
14 Psychotropic Drugs Phase 1, Phase 2
15 Tranquilizing Agents Phase 1, Phase 2
16 Fluorodeoxyglucose F18 Phase 2
17 Radiopharmaceuticals Phase 2
18 taxane Phase 1
19
Amantadine Approved 768-94-5 2130
20
Carbidopa Approved 28860-95-9 34359 38101
21
Entacapone Approved, Investigational 130929-57-6 5281081
22
Levodopa Approved 59-92-7 6047
23
Pramipexole Approved, Investigational 104632-26-0 59868 119570
24
Ropinirole Approved, Investigational 91374-20-8, 91374-21-9 5095 497540
25 Vaccines

Interventional clinical trials:

(show all 29)
id Name Status NCT ID Phase
1 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4
2 Effects of Coenzyme Q10 in PSP and CBD Completed NCT00532571 Phase 2, Phase 3
3 A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration Completed NCT00703677 Phase 1, Phase 2
4 Electrical Polarization of the Brain in Corticobasal Syndrome Completed NCT00273897 Phase 2
5 The Differential Diagnosis of Parkinson's Disease and Parkinsonism by Positron-emission Tomography Completed NCT01824056 Phase 2
6 Davunetide (AL-108) in Predicted Tauopathies - Pilot Study Active, not recruiting NCT01056965 Phase 2
7 Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers Completed NCT02167594 Phase 1
8 Safety Study of TPI-287 to Treat CBS and PSP Active, not recruiting NCT02133846 Phase 1
9 Innovative Biomarkers in Alzheimer's Disease and Frontotemporal Dementia (FTD): Preventative and Personalized Unknown status NCT01403519
10 The Sunnybrook Dementia Study: Mapping Brain Changes in Alzheimer's, Vascular and Other Dementias Unknown status NCT01800214
11 Repetitive Transcranial Magnetic Stimulation (TMS) for Progressive Supranuclear Palsy and Corticobasal Degeneration Completed NCT01174771
12 Study of Tongue Pressures Completed NCT00013832
13 PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK Recruiting NCT02778607
14 4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2 Recruiting NCT02966145
15 Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) Recruiting NCT02365922
16 More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease Recruiting NCT03076671
17 Parkinson's Disease, Diagnostic Observations (PADDO) Recruiting NCT01249768
18 Gait Analysis in Neurological Disease Recruiting NCT02994719
19 Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography. Recruiting NCT02132052
20 ADDIA Proof-of-Performance Clinical Study Recruiting NCT03030586
21 Positron Emission Tomography (PET) Imaging of Tau Pathology in Neurodegenerative Disease Recruiting NCT03143374
22 The Swedish BioFINDER 2 Study Recruiting NCT03174938
23 Diagnosing Frontotemporal Lobar Degeneration Recruiting NCT02964637
24 Genetic Characterization of Movement Disorders and Dementias Recruiting NCT02014246
25 Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks Recruiting NCT03153371
26 4 Repeat Tauopathy Neuroimaging Initiative Active, not recruiting NCT01804452
27 Study for the Early Diagnosis of Parkinson's Disease Active, not recruiting NCT02283073
28 Vaccination Uptake (VAX) in PD Not yet recruiting NCT02874274
29 SudoScan as a Biomarker of Parkinson's Disease Not yet recruiting NCT02767037

Search NIH Clinical Center for Corticobasal Degeneration

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Genetic Tests for Corticobasal Degeneration

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Anatomical Context for Corticobasal Degeneration

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MalaCards organs/tissues related to Corticobasal Degeneration:

39
Cortex, Brain, Eye, Spinal Cord, Thalamus
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Publications for Corticobasal Degeneration

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Articles related to Corticobasal Degeneration:

(show top 50) (show all 407)
id Title Authors Year
1
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy. ( 26936765 )
2016
2
Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options. ( 27526039 )
2016
3
Fulminant corticobasal degeneration: Agrypnia excitata in corticobasal syndrome. ( 26873956 )
2016
4
Progressive supranuclear palsy and corticobasal degeneration: Diagnostic challenges and clinicopathological considerations. ( 27561438 )
2016
5
Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration. ( 26818518 )
2016
6
Incidental corticobasal degeneration. ( 27461552 )
2016
7
Visual signs and symptoms of corticobasal degeneration. ( 27553583 )
2016
8
Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. ( 27842611 )
2016
9
Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. ( 27111692 )
2016
10
Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. ( 27815633 )
2016
11
Presymptomatic anterior frontal involvement in corticobasal degeneration. ( 27913406 )
2016
12
Diagnoses of corticobasal syndrome and corticobasal degeneration. ( 26876110 )
2016
13
[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration. ( 27645292 )
2016
14
Poster 332 Corticobasal Degeneration with Spastic Left Hemiparesis, Dystonic Posturing, and Rigidity: A Case Report. ( 27673088 )
2016
15
Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology. ( 27797812 )
2016
16
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration. ( 27709685 )
2016
17
Dopamine transporter imaging as a diagnostic modality for atypical Alzheimer's disease mimicking corticobasal degeneration. ( 26781839 )
2016
18
Therapeutic interventions in parkinsonism: Corticobasal degeneration. ( 26382843 )
2015
19
Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. ( 25534024 )
2015
20
F-18 fluoro-d-glucose positron emission tomography/computed tomography in a patient with corticobasal degeneration. ( 25829747 )
2015
21
Progressive Dopamine Transporter Binding Loss in Autopsy-Confirmed Corticobasal Degeneration. ( 26485425 )
2015
22
Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. ( 26077951 )
2015
23
Corticobasal degeneration: clinical characteristics and multidisciplinary therapeutic approach in 26 patients. ( 25917399 )
2015
24
Pathological features of preclinical or early clinical stages of corticobasal degeneration: a comparison with advanced cases. ( 25708668 )
2015
25
Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. ( 25701010 )
2015
26
Corticobasal degeneration initially developing motor versus non-motor symptoms: a comparative clinicopathological study. ( 25186621 )
2014
27
A disease-specific metabolic brain network associated with corticobasal degeneration. ( 25208922 )
2014
28
Astrocytic inclusions in progressive supranuclear palsy and corticobasal degeneration. ( 25124031 )
2014
29
Suppression of myoclonus in corticobasal degeneration by levetiracetam. ( 24926409 )
2014
30
Neuroleptic Malignant Syndrome in an Elderly Patient With Normal Pressure Hydrocephalus Overlapping Corticobasal Degeneration. ( 25280791 )
2014
31
Validation of the new consensus criteria for the diagnosis of corticobasal degeneration. ( 24521567 )
2014
32
Diagnosis and treatment of corticobasal degeneration. ( 24469408 )
2014
33
Argyrophilic grains are reliable disease-specific features of corticobasal degeneration. ( 24335531 )
2014
34
Managing Advanced Progressive Supranuclear Palsy and Corticobasal Degeneration in a Palliative Care Unit: Admission Triggers and Outcomes. ( 25550443 )
2014
35
Corticobasal degeneration. ( 24963675 )
2014
36
Ultrastructural differences in pretangles between Alzheimer disease and corticobasal degeneration revealed by comparative light and electron microscopy. ( 25497147 )
2014
37
An autopsied case of corticobasal degeneration showing severe cerebral atrophy over a protracted disease course of 16 years. ( 25516199 )
2014
38
Apraxia in anti-GAD associated stiff person syndrome: Link to corticobasal degeneration? ( 25100431 )
2014
39
Concomitant accumulation of I+-synuclein and TDP-43 in a patient with corticobasal degeneration. ( 25209854 )
2014
40
In vivo decreased dopamine transporter uptake in corticobasal degeneration presenting with primary progressive aphasia without parkinsonism. ( 24919427 )
2014
41
Exome sequencing in familial corticobasal degeneration. ( 23867865 )
2013
42
Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration. ( 24121548 )
2013
43
"Atypical" atypical parkinsonism: new genetic conditions presenting with features of progressive supranuclear palsy, corticobasal degeneration, or multiple system atrophy-a diagnostic guide. ( 23720239 )
2013
44
Incidental corticobasal degeneration in a 76-year-old woman. ( 23006474 )
2013
45
Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD. ( 23371366 )
2013
46
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration. ( 23121727 )
2013
47
Normal dopamine transporter SPECT in neuropathologically confirmed corticobasal degeneration. ( 23471615 )
2013
48
Neuropsychiatry of corticobasal degeneration and progressive supranuclear palsy. ( 23611349 )
2013
49
Criteria for the diagnosis of corticobasal degeneration. ( 23359374 )
2013
50
Long-Term Exercise Training for an Individual With Mixed Corticobasal Degeneration and Progressive Supranuclear Palsy Features: 10-Year Case Report Follow-up. ( 24114439 )
2013
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Variations for Corticobasal Degeneration

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Expression for Corticobasal Degeneration

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Search GEO for disease gene expression data for Corticobasal Degeneration.
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Pathways for Corticobasal Degeneration

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Pathways related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
NFAT and Cardiac Hypertrophy 60
Show member pathways
 12.65 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
2
Development Slit-Robo signaling 21
Show member pathways
 12.35 CFL1 MAPT ROCK1 ROCK2
3
Cytoskeletal Signaling 4
12.32 CFL1 MAPT ROCK1 ROCK2
4
Prolactin Signaling Pathway 1 37
Show member pathways
 12.22 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
5
EphB-EphrinB Signaling 60
Show member pathways
 12.18 MAPT ROCK1 ROCK2 SOS1
6
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 1
11.92 CFL1 MAPT MTOR RPS6KB1
7
EGF/EGFR Signaling Pathway 1
11.87 CFL1 MTOR ROCK1 RPS6KB1 SOS1
8
Glioblastoma Multiforme 60
11.77 MTOR RPS6KB1 SOS1
9
IL2 signaling events mediated by PI3K 1
Show member pathways
 11.48 MTOR RPS6KB1 SOS1
10
Proteoglycans in cancer 37
11.41 HSPB2 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
11
G-protein signaling M-RAS regulation pathway 21
Show member pathways
 11.36 CFL1 ROCK1 ROCK2 SOS1
12
TGF-beta Signaling Pathways 61
11.35 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
13
RhoA signaling pathway 1
11.22 CFL1 ROCK1 ROCK2
14
BDNF-TrkB Signaling 1
11.11 MTOR RPS6KB1 SOS1
15
G13 Signaling Pathway 1
11.07 CFL1 ROCK1 ROCK2 RPS6KB1
16
Insulin signalling in human adipocytes (diabetic condition) 1
Show member pathways
 10.73 MTOR RPS6KB1
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GO Terms for Corticobasal Degeneration

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Cellular components related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.86 CFL1 CRYAB HSPB2 KIF13B MAPT MOBP
2 neuronal cell body GO:0043025 9.63 CFL1 MAPT MTOR PITX3 SOS1 UCHL1
3 axon GO:0030424 9.62 CRYAB KIF13B MAPT UCHL1
4 myelin sheath GO:0043209 9.02 CRYAB MOBP PGAM1 RPS27A UCHL1
5 cytosol GO:0005829 10.07 CRYAB HSPB2 KIF13B MAPT MTOR PGAM1

Biological processes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 CFL1 CRYAB PRDX5 RPS27A RPS6KB1
2 regulation of cellular response to heat GO:1900034 9.69 CRYAB MAPT MTOR
3 regulation of macroautophagy GO:0016241 9.65 GBA MTOR UCHL1
4 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.61 ROCK1 ROCK2 RPS27A
5 regulation of focal adhesion assembly GO:0051893 9.58 ROCK1 ROCK2
6 regulation of establishment of cell polarity GO:2000114 9.57 ROCK1 ROCK2
7 regulation of stress fiber assembly GO:0051492 9.56 ROCK1 ROCK2
8 TOR signaling GO:0031929 9.55 MTOR RPS6KB1
9 negative regulation of cell size GO:0045792 9.52 CFL1 MTOR
10 Rho protein signal transduction GO:0007266 9.5 CFL1 ROCK1 ROCK2
11 regulation of keratinocyte differentiation GO:0045616 9.49 ROCK1 ROCK2
12 negative regulation of protein homooligomerization GO:0032463 9.46 CRYAB GBA
13 regulation of actin cytoskeleton organization GO:0032956 9.43 MTOR ROCK1 ROCK2
14 axonal transport of mitochondrion GO:0019896 9.4 MAPT UCHL1
15 regulation of establishment of endothelial barrier GO:1903140 9.37 ROCK1 ROCK2
16 negative regulation of myosin-light-chain-phosphatase activity GO:0035509 9.16 ROCK1 ROCK2
17 negative regulation of bicellular tight junction assembly GO:1903347 8.96 ROCK1 ROCK2
18 response to amino acid GO:0043200 8.8 CFL1 MTOR RPS6KB1

Molecular functions related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 CFL1 CRYAB GBA HSPB2 KIF13B MAPT
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Sources for Corticobasal Degeneration

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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