CBGD
MCID: CRT033
MIFTS: 59

Corticobasal Degeneration (CBGD) malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Corticobasal Degeneration

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44NIH Rare Diseases, 45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to progressive supranuclear palsy and dementia. An important gene associated with Corticobasal Degeneration is MAPT (microtubule-associated protein tau), and among its related pathways are MNAR-PELP1 and Estrogen Receptor Interaction and Development Leptin signaling via JAK STAT and MAPK cascades. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and eye, and related mouse phenotypes are taste/olfaction and tumorigenesis.

NIH Rare Diseases:44 Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/4/2010

Wikipedia:66 Corticobasal degeneration (CBD) or Corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

Aliases & Classifications for Corticobasal Degeneration

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Sources:
44NIH Rare Diseases, 45NINDS, 50Orphanet, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
corticobasal degeneration:
Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

corticobasal degeneration 44 45 50 63
cortical-basal ganglionic degeneration 44
cortico-basal ganglionic degeneration 44
cbgd 44


External Ids:

ICD10 via Orphanet27 G31.0
SNOMED-CT via Orphanet60 18842008
UMLS via Orphanet64 C0393570

Related Diseases for Corticobasal Degeneration

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Corticobasal Degeneration family:

Corticobasal Degeneration, Mapt-Related

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1progressive supranuclear palsy31.8HCRT, MAPT, SNCA, RPS27A
2dementia31.2HCRT, MAPK3, GBA, SNCA, RPS27A, MAPT
3aphasia31.2TARDBP, MAPT
4frontotemporal dementia31.2RPS27A, TARDBP, MAPT, SNCA
5pick's disease31.1RPS27A, MAPT, TARDBP, SNCA
6tauopathy31.0MAPT, SNCA, RPS27A
7primary progressive aphasia31.0MAPT, RPS27A
8parkinson's disease30.9SNCA, MAPT, PITX3, GBA, RPS27A
9multiple system atrophy30.9RPS27A, MAPT, SNCA
10creutzfeldt-jakob disease30.8SNCA, RPS27A, MAPT
11semantic dementia30.7RPS27A, MAPT
12alzheimer's disease30.7TARDBP, HMOX1, HCRT, HSPB2, CASP3, HRAS
13motor neuron disease30.6RPS27A, MAPT, SNCA, TARDBP
14lateral sclerosis30.5MAPT, SNCA
15rem sleep behavior disorder30.4SNCA
16amyotrophic lateral sclerosis30.4SNCA, HSPB2, TARDBP, MAPT, CASP3, RPS27A
17huntington's disease30.3CASP3
18striatonigral degeneration30.3RPS27A, SNCA
19apraxia10.8
20cerebritis10.7
21neuronitis10.6
22myoclonus10.6
23dystonia10.4
24hemiparkinsonism-hemiatrophy syndrome10.3
25corticobasal degeneration, mapt-related10.3
26neuronal intranuclear inclusion disease10.1RPS27A
27antiphospholipid syndrome10.1
28parametritis10.1
29olivopontocerebellar atrophy10.1
30arachnoiditis10.1
31complex regional pain syndrome10.1
32pulmonary fibrosis10.1
33arachnoid cysts10.1
34hereditary diffuse leukoencephalopathy with spheroids10.1
35neurosyphilis10.1
36paine syndrome10.1
37progressive non-fluent aphasia10.1
38ataxia10.1
39memory impairment10.1
40posterior cortical atrophy10.1
41normal pressure hydrocephalus10.1MAPT, HCRT
42hypersplenism10.1GBA
43inclusion body myositis10.1RPS27A, MAPT
44parkinson disease 110.1SNCA
45myotonic dystrophy10.1MAPT, HSPB2, HCRT
46neuroblastoma10.1MYC
47parkinson disease type 310.1MAPT, SNCA
48neuroaxonal dystrophy10.1RPS27A, SNCA
49central nervous system disease10.1HCRT, MAPT, HMOX1
50niemann-pick disease10.1SNCA, HCRT, MAPT

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to corticobasal degeneration

Symptoms for Corticobasal Degeneration

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Drugs & Therapeutics for Corticobasal Degeneration

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Corticobasal Degeneration

Drug clinical trials:

Search ClinicalTrials for Corticobasal Degeneration

Search NIH Clinical Center for Corticobasal Degeneration

Search CenterWatch for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

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Anatomical Context for Corticobasal Degeneration

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34MalaCards
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MalaCards organs/tissues related to Corticobasal Degeneration:

34
Cortex, Brain, Eye, Spinal cord, Thalamus

Animal Models for Corticobasal Degeneration or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Corticobasal Degeneration:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2SNCA, MAPK1, MAPT, CASP3
2MP:00020068.7MYC, MAPK1, MAPT, MAPK3, HRAS
3MP:00053798.4HRAS, HMOX1, CASP3, SNCA, MYC, PITX3
4MP:00053708.3GBA, PITX3, MYC, MAPK1, MAPK3, HMOX1
5MP:00053888.1GBA, PITX3, HCRT, MAPK1, MAPK3, CASP3
6MP:00053697.8HCRT, HSPB2, MYC, MAPK1, MAPT, MAPK3
7MP:00053907.8GBA, PITX3, HSPB2, MYC, SNCA, CASP3
8MP:00053677.7CFL1, SNCA, MAPT, CSF3, CASP3, HMOX1
9MP:00030127.6PITX3, CFL1, MYC, SNCA, MAPT, CASP3
10MP:00053977.2GBA, PITX3, MYC, MAPK1, MAPT, MAPK3
11MP:00053856.7GBA, HCRT, CFL1, HSPB2, MYC, SNCA
12MP:00053876.5SNCA, MYC, HSPB2, PITX3, GBA, MAPK1
13MP:00107716.5GBA, PITX3, CFL1, MYC, SNCA, MAPK1
14MP:00053766.4MYC, CFL1, HCRT, PITX3, GBA, SNCA
15MP:00107686.4SNCA, MYC, HSPB2, CFL1, GBA, MAPK1
16MP:00053846.2MYC, HSPB2, CFL1, PITX3, GBA, SNCA
17MP:00036316.1HSPB2, CFL1, HCRT, PITX3, GBA, MYC
18MP:00053865.8HRAS, GBA, PITX3, HCRT, CFL1, HSPB2
19MP:00053785.8MYC, HSPB2, CFL1, HCRT, PITX3, GBA

Publications for Corticobasal Degeneration

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53PubMed
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Articles related to Corticobasal Degeneration:

(show top 50)    (show all 366)
idTitleAuthorsYear
1
Argyrophilic grains are reliable disease-specific features of corticobasal degeneration. (24335531)
2014
2
Analysis of PITX3 gene in patients with multisystem atrophy, progressive supranuclear palsy and corticobasal degeneration. (23694789)
2013
3
A case of an arachnoid cyst masquerading as corticobasal degeneration. (23061395)
2012
4
A case of Creutzfeldt-Jakob disease mimicking corticobasal degeneration: FDG PET, SPECT, and MRI findings. (22691528)
2012
5
Acalculia in autopsy-proven corticobasal degeneration. (21321355)
2011
6
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease. (20629131)
2010
7
Seizures in corticobasal degeneration: a case report. (19544144)
2009
8
Clinicopathological and genetic correlates of frontotemporal lobar degeneration and corticobasal degeneration. (18357425)
2008
9
Corticobasal degeneration: clinical aspects. (18631773)
2008
10
Dysfunctional facial emotional expression and comprehension in a patient with corticobasal degeneration. (17786775)
2007
11
Co-occurrence of radiological features of progressive supranuclear palsy and corticobasal degeneration. (17272907)
2007
12
Rapid eye movement (REM) sleep without atonia in two patients with corticobasal degeneration (CBD). (17055327)
2007
13
Corticobasal degeneration. (18808957)
2007
14
The clinical overlap between the corticobasal degeneration syndrome and other diseases of the frontotemporal spectrum: three case reports. (17726244)
2007
15
Sporadic SCA8 mutation resembling corticobasal degeneration. (15823478)
2005
16
Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases. (15735950)
2005
17
Creutzfeldt-Jakob disease mimicking corticobasal degeneration clinical and MRI data of a case. (15795791)
2005
18
Neurosyphilis masquerading as corticobasal degeneration. (15389980)
2004
19
Rapid onset of pergolide-induced pulmonary fibrosis in a patient with corticobasal degeneration. (15222217)
2004
20
Corticobasal degeneration syndrome with basal ganglia calcification: Fahr's disease as a corticobasal look-alike? (12621646)
2003
21
Limb-kinetic apraxia in corticobasal degeneration: clinical and kinematic features. (12518300)
2003
22
Cholinergic neuronal loss in the basal forebrain and mesopontine tegmentum of progressive supranuclear palsy and corticobasal degeneration. (12536222)
2003
23
Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction. (14581681)
2003
24
Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration. (12084445)
2002
25
Unilateral periodic limb movements during sleep in corticobasal degeneration. (11748759)
2001
26
Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy. (11303763)
2001
27
Rhythmic cortical and muscle discharges induced by fatigue in corticobasal degeneration. (10699413)
2000
28
Phenotypes and prognosis: clinicopathologic studies of corticobasal degeneration. (10624482)
2000
29
Aphasia in corticobasal degeneration. (10624476)
2000
30
Immunohistochemistry distinguishes: between Pick's disease and corticobasal degeneration. (11185644)
2000
31
Neuropsychiatric aspects of corticobasal degeneration. (10624478)
2000
32
The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. (11087783)
2000
33
Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease. (10965796)
2000
34
Cerebral blood flow in corticobasal degeneration and progressive supranuclear palsy. (10718204)
2000
35
Contribution of PET studies in diagnosis of corticobasal degeneration. (10894990)
2000
36
Cognitive and magnetic resonance imaging aspects of corticobasal degeneration and progressive supranuclear palsy. (10449111)
1999
37
Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms. (10037497)
1999
38
A comparison of tau protein in cerebrospinal fluid between corticobasal degeneration and progressive supranuclear palsy. (10025574)
1999
39
Heterogeneity of glucose metabolism in corticobasal degeneration. (9879684)
1998
40
Neuropsychological and neuroimaging correlates in corticobasal degeneration. (10933454)
1998
41
Increased CSF tau protein in corticobasal degeneration. (9457628)
1998
42
Paired helical filaments in corticobasal degeneration: the fine fibrillary structure with NanoVan. (9409702)
1997
43
Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy. (8702002)
1996
44
Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy. (7572077)
1995
45
Unique myoclonic pattern in corticobasal degeneration. (7753055)
1995
46
Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy. (7985491)
1994
47
Unusual case of corticobasal degeneration with tau/Gallyas-positive neuronal and glial tangles. (7879609)
1994
48
Corticobasal degeneration: a report of three cases. (8046710)
1994
49
Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy. (7526285)
1994
50
Corticobasal degeneration: decreased and asymmetrical glucose consumption as studied with PET. (1484530)
1992

Variations for Corticobasal Degeneration

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Expression for genes affiliated with Corticobasal Degeneration

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for genes affiliated with Corticobasal Degeneration

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Sources:
51PathCards, 54QIAGEN, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 13EMD Millipore, 31KEGG, 52PharmGKB, 62Tocris Bioscience
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Pathways related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HRAS, MAPK3, MAPK1
2
Show member pathways
9.5HRAS, MAPK3, MAPK1
39.5MAPK1, MAPK3, HRAS
49.4MAPK1, MAPK3, MYC
5
Show member pathways
Cytoskeleton remodeling Reverse signaling by ephrin B61
9.3MAPK1, MAPT, MAPK3, HRAS
6
Show member pathways
9.3MAPK3, RPS27A, HRAS, MAPK1
7
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.2HRAS, MAPK3, MAPK1, MYC
8
Show member pathways
Immune response IL 3 activation and signaling pathway61
9.2HRAS, MAPK1, MYC, MAPK3
9
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.2MAPK3, MAPK1, HRAS, MYC
109.2HRAS, MAPK1, MAPK3, MYC
119.2MAPK1, HRAS, MAPK3, MYC
12
Show member pathways
EPO Receptor Signaling39
EPO signaling pathway39
9.2HRAS, MYC, MAPK1, MAPK3
139.2MAPK3, MAPK1, MYC, HRAS
14
Show member pathways
Development A1 receptor signaling61
G protein signaling G Protein alpha q signaling cascades61
9.2MYC, MAPK1, HRAS, MAPK3
15
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.2MYC, MAPK1, MAPK3, HRAS
169.2MAPK3, HRAS, MYC, MAPK1
17
Show member pathways
9.2HRAS, MAPK3, MYC, MAPK1
18
Show member pathways
9.1HRAS, MAPK3, CASP3, MAPK1
19
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.1HRAS, CASP3, MAPK3, MAPK1
20
Show member pathways
9.1HRAS, MAPK1, MAPK3, CASP3
219.1MAPK3, CASP3, HRAS, MAPK1
229.0MYC, MAPK3, CASP3, MAPK1
23
Show member pathways
IL-2 Signaling pathway39
9.0MAPT, MAPK1, MYC, HRAS, MAPK3
248.9HRAS, MAPT, MAPK1, CASP3, MAPK3
25
Show member pathways
Alzheimers Disease39
8.9SNCA, MAPK1, MAPT, CASP3, MAPK3
268.8CASP3, MAPK3, MAPT, MAPK1, MYC
278.8HRAS, MAPK3, MAPK1, MYC, SNCA
288.8MAPK1, CASP3, HMOX1, HRAS, MYC
298.8MYC, MAPK1, CASP3, HRAS, MAPK3
30
Show member pathways
Signal transduction PTEN pathway61
8.8HRAS, MAPK3, CASP3, MYC, MAPK1
31
Show member pathways
8.8MYC, CASP3, MAPK3, MAPK1, HRAS
32
Show member pathways
8.8HRAS, CASP3, MAPK3, MAPK1, MYC
33
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.8MAPK1, MAPK3, CASP3, HRAS, MYC
34
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
8.8MAPK1, CASP3, HRAS, MYC, MAPK3
35
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.8MAPK1, MAPK3, CASP3, HRAS, MYC
36
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
8.8HRAS, CASP3, MAPK3, MAPK1, MYC
378.7CFL1, MAPK1, MAPK3, HRAS
38
Show member pathways
RAC1 signaling pathway39
8.7MAPK1, MAPK3, HRAS, CFL1
398.6HRAS, MYC, MAPK1, MAPK3, CSF3
40
Show member pathways
8.6MAPK1, CASP3, MAPT, MAPK3, SNCA, HRAS
418.6CASP3, MAPK3, CFL1, MAPK1
42
Show member pathways
8.3CASP3, MAPK3, CFL1, MAPK1, HRAS
438.3CASP3, HRAS, MYC, HSPB2, MAPK3, MAPK1
44
Show member pathways
8.3MYC, MAPK1, MAPK3, CSF3, CASP3, HRAS
458.1MAPK3, MAPT, CASP3, HRAS, MAPK1, CFL1
46
Show member pathways
MAPK signaling pathway39
8.1HSPB2, MAPK1, MAPT, MAPK3, CASP3, HRAS
47
Show member pathways
8.0MAPK3, MAPK1, MYC, CFL1, CASP3, HRAS
48
Show member pathways
7.8CFL1, MAPK1, MAPK3, CSF3, HRAS, CASP3
49
Show member pathways
7.8CFL1, MAPK3, MYC, MAPK1, CASP3, MAPT
50
Show member pathways
7.4MAPK1, MAPK3, CSF3, CASP3, CFL1, MYC

Compounds for genes affiliated with Corticobasal Degeneration

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1thioflavine s4610.1MAPT, RPS27A, SNCA
2formate469.4RPS27A, SNCA, MAPT, PRDX5
3radicicol46 62 1211.4HSPB2, RPS27A, MAPK1, MAPK3
46-hydroxydopamine469.3SNCA, CASP3, MYC, HMOX1, RPS27A
5rotenone469.3RPS27A, MAPK1, CASP3, HMOX1, SNCA
6roscovitine469.2MAPT, CASP3, MYC, MAPK1, MAPK3
7nmda46 3010.2MAPK3, MAPK1, RPS27A, HRAS, HCRT, MAPT
8herbimycin a46 6210.2RPS27A, HRAS, MAPK3, MYC, MAPK1
9sp 60012546 6210.2SNCA, CASP3, MAPK3, HMOX1, MAPK1
10sulforaphane469.1PRDX5, MAPK1, CASP3, HMOX1
11acetylcholine46 52 30 25 1213.0HCRT, HSPB2, SNCA, RPS27A, MAPT, HMOX1
12valine469.0SNCA, RPS27A, MAPT, CSF3, HRAS
13butyrate469.0CASP3, MAPK3, MAPT, MAPK1, MYC, RPS27A
14actinomycin d468.9MYC, RPS27A, MAPT, CASP3, HMOX1, MAPK1
15quercetin46 62 25 1211.8HSPB2, MAPK1, MAPK3, CASP3, HMOX1
16resveratrol46 62 25 1211.8CASP3, MAPK3, MAPK1, PRDX5, HMOX1
17imatinib46 52 1210.8MYC, RPS27A, MAPK1, CSF3, CASP3
18ly294002468.8HRAS, CASP3, MAPK3, MAPK1, MYC, HMOX1
19thapsigargin46 629.8HCRT, CASP3, MAPK3, MAPK1, HSPB2
20lactacystin468.8MAPK1, SNCA, HMOX1, RPS27A, CASP3, MAPT
21mg 13246 629.8RPS27A, SNCA, MYC, MAPK1, HMOX1, CASP3
22genistein46 30 62 3 25 1213.7MYC, HRAS, CASP3, MAPK3, MAPT, MAPK1
23melphalan46 52 1210.7PRDX5, MAPK3, MYC, CSF3
24sb 20358046 629.6HSPB2, SNCA, HMOX1, CASP3, MAPK3, MAPK1
25rapamycin468.6HRAS, CASP3, RPS27A, SNCA, MAPK3, MAPK1
26pd 98,059468.5HRAS, MAPK1, CASP3, MYC, HSPB2, MAPK3
27dopamine46 30 25 1211.5PITX3, HCRT, SNCA, RPS27A, MAPK3, MAPT
28paclitaxel46 52 1210.5CASP3, HRAS, CSF3, MAPK3, MAPT, MAPK1
29arsenite46 259.4HMOX1, CASP3, MAPK3, MAPK1, MYC, HSPB2
30pge2468.4HRAS, HMOX1, MAPK3, MAPK1, RPS27A, SNCA
31dexamethasone46 52 30 1211.4HCRT, MYC, RPS27A, MAPK1, MAPK3, CSF3
32curcumin468.3MYC, HMOX1, MAPK3, CASP3, MAPK1, RPS27A
33glutamine468.3HRAS, MAPT, HSPB2, PRDX5, RPS27A, SNCA
34arginine468.2SNCA, RPS27A, MAPK3, HMOX1, HRAS, HSPB2
35cycloheximide468.2MAPT, MAPK1, RPS27A, MYC, CSF3, CASP3
36nitric oxide46 25 1210.2MAPK3, HRAS, MAPK1, SNCA, HCRT, PRDX5
37doxorubicin46 52 1210.2HSPB2, MYC, HRAS, HMOX1, CASP3, MAPT
384-hydroxynonenal46 259.1MAPK1, SNCA, MYC, PRDX5, RPS27A, HMOX1
39cyclosporin a46 30 6210.1MYC, PRDX5, RPS27A, MAPT, HRAS, HMOX1
40cysteine468.0GBA, MAPT, PRDX5, SNCA, HRAS, RPS27A
41estrogen468.0HRAS, MAPK3, MYC, PRDX5, RPS27A, MAPK1
42n acetylcysteine467.8HMOX1, CASP3, MAPK3, MAPK1, RPS27A, SNCA
43oxygen46 258.8SNCA, PRDX5, GBA, HSPB2, HMOX1, HRAS
44vegf467.6MAPK1, MAPK3, CSF3, CASP3, HMOX1, RPS27A
45h2o2467.4RPS27A, MAPK1, MAPK3, HMOX1, HRAS, SNCA
46retinoic acid46 258.3MAPK3, CASP3, HMOX1, MYC, PRDX5, RPS27A
47tyrosine467.3CSF3, MAPK3, HRAS, MAPK1, RPS27A, SNCA
48superoxide46 258.2HMOX1, HSPB2, HRAS, TARDBP, CASP3, CSF3
49serine467.1MAPK3, CASP3, MAPT, HRAS, MAPK1, RPS27A
50cisplatin46 52 62 1210.0HSPB2, MYC, CSF3, HMOX1, PRDX5, CASP3

GO Terms for genes affiliated with Corticobasal Degeneration

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Sources:
17Gene Ontology
See all sources

Cellular components related to Corticobasal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pseudopodiumGO:0311439.8MAPK3, MAPK1
2caveolaGO:0059019.2MAPK1, MAPK3, HMOX1
3cytosolGO:0058296.7CASP3, HMOX1, MAPK3, MAPT, MAPK1, RPS27A
4nucleusGO:0056345.4HRAS, PITX3, TARDBP, HMOX1, CASP3, MAPK3

Biological processes related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1regulation of early endosome to late endosome transportGO:200064110.2MAPK1, MAPK3
2regulation of Golgi inheritanceGO:09017010.2MAPK1, MAPK3
3response to epidermal growth factorGO:07084910.2MAPK3, MAPK1
4caveolin-mediated endocytosisGO:07258410.2MAPK3, MAPK1
5regulation of stress-activated MAPK cascadeGO:03287210.1MAPK3, MAPK1
6regulation of long-term neuronal synaptic plasticityGO:04816910.0HRAS, SNCA
7response to estrogenGO:0436279.9GBA, MAPK1, HMOX1
8stress-activated MAPK cascadeGO:0514039.9MAPK3, MAPK1, RPS27A
9regulation of cytoskeleton organizationGO:0514939.9MAPK3, MAPK1
10toll-like receptor 10 signaling pathwayGO:0341669.9RPS27A, MAPK1, MAPK3
11toll-like receptor 5 signaling pathwayGO:0341469.9RPS27A, MAPK1, MAPK3
12positive regulation of actin cytoskeleton reorganizationGO:20002519.9HRAS, CSF3
13toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.9RPS27A, MAPK1, MAPK3
14toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.9RPS27A, MAPK1, MAPK3
15regulation of sequence-specific DNA binding transcription factor activityGO:0510909.9HMOX1, MAPK3, MAPK1
16activation of MAPKK activityGO:0001869.9HRAS, MAPK3, MAPK1
17toll-like receptor 9 signaling pathwayGO:0341629.9RPS27A, MAPK1, MAPK3
18toll-like receptor 2 signaling pathwayGO:0341349.9MAPK3, MAPK1, RPS27A
19TRIF-dependent toll-like receptor signaling pathwayGO:0356669.9MAPK3, MAPK1, RPS27A
20MyD88-independent toll-like receptor signaling pathwayGO:0027569.9RPS27A, MAPK1, MAPK3
21MyD88-dependent toll-like receptor signaling pathwayGO:0027559.9RPS27A, MAPK1, MAPK3
22toll-like receptor 3 signaling pathwayGO:0341389.9MAPK3, MAPK1, RPS27A
23Ras protein signal transductionGO:0072659.9MAPK1, MAPK3, HRAS
24activation of MAPK activityGO:0001879.8RPS27A, MAPK1, MAPK3
25toll-like receptor 4 signaling pathwayGO:0341429.8RPS27A, MAPK1, MAPK3
26negative regulation of neuron apoptotic processGO:0435249.8HRAS, HMOX1, SNCA
27JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8MAPK3, MAPK1
28toll-like receptor signaling pathwayGO:0022249.8RPS27A, MAPK1, MAPK3
29fibroblast growth factor receptor signaling pathwayGO:0085439.7RPS27A, MAPK1, MAPK3, HRAS
30Fc-epsilon receptor signaling pathwayGO:0380959.7RPS27A, MAPK1, MAPK3, HRAS
31epidermal growth factor receptor signaling pathwayGO:0071739.7HRAS, MAPK3, MAPK1, RPS27A
32regulation of excitatory postsynaptic membrane potentialGO:0600799.6SNCA, HCRT
33insulin receptor signaling pathwayGO:0082869.6HRAS, MAPK3, MAPK1
34MAPK cascadeGO:0001659.6HRAS, MAPK3, MAPK1, MYC
35small GTPase mediated signal transductionGO:0072649.5HRAS, HMOX1, MAPK3, MAPK1
36organ morphogenesisGO:0098879.5HRAS, MAPK3, MAPK1, PITX3
37apoptotic processGO:0069159.3RPS27A, MAPK1, MAPT, MAPK3, CASP3
38neurotrophin TRK receptor signaling pathwayGO:0480119.3RPS27A, MAPK1, MAPK3, CASP3, HRAS
39Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.3MAPK3, MAPK1, CFL1
40cellular response to DNA damage stimulusGO:0069749.2CASP3, MAPK1, MYC
41positive regulation of cell proliferationGO:0082849.1MYC, MAPK1, CSF3, HRAS
42positive regulation of transcription from RNA polymerase II promoterGO:0459449.1MYC, RPS27A, MAPK3, CSF3, HRAS
43axon guidanceGO:0074118.9HRAS, MAPK3, MAPK1, CFL1
44innate immune responseGO:0450878.8CFL1, RPS27A, MAPK1, MAPK3, HRAS
45blood coagulationGO:0075968.7CFL1, MAPK1, MAPK3, HRAS
46negative regulation of apoptotic processGO:0430668.2CFL1, MYC, PRDX5, SNCA, RPS27A, CASP3

Molecular functions related to Corticobasal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase activityGO:0047079.7MAPK1, MAPK3
2cysteine-type endopeptidase inhibitor activity involved in apoptotic processGO:0430279.5SNCA, PRDX5
3phosphotyrosine bindingGO:0017849.5MAPK3, MAPK1
4protein bindingGO:0055156.2MAPK1, PGAM1, MYC, SNCA, CFL1, MAPT

Products for genes affiliated with Corticobasal Degeneration

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Sources for Corticobasal Degeneration

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet