CBGD
MCID: CRT033
MIFTS: 45

Corticobasal Degeneration (CBGD) malady

Neuronal diseases category

Summaries for Corticobasal Degeneration

About this section
Sources:
42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NINDS:43 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to progressive supranuclear palsy and dementia. An important gene associated with Corticobasal Degeneration is MAPT (microtubule-associated protein tau), and among its related pathways are Nongenotropic Androgen signaling and SHC1 events in ERBB2 signaling. The compounds cycloheximide and butyrate have been mentioned in the context of this disorder. Affiliated tissues include cortex and brain, and related mouse phenotypes are taste/olfaction and renal/urinary system.

NIH Rare Diseases:42 Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/4/2010

Wikipedia:63 Corticobasal degeneration (CBD) or Corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

Aliases & Classifications for Corticobasal Degeneration

About this section
Sources:
42NIH Rare Diseases, 43NINDS, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
corticobasal degeneration:
Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

corticobasal degeneration 42 43 48 60
cortical-basal ganglionic degeneration 42
cortico-basal ganglionic degeneration 42
cbgd 42


External Ids:

ICD10 via Orphanet26 G31.0
SNOMED-CT via Orphanet57 18842008
UMLS via Orphanet61 C0393570

Related Diseases for Corticobasal Degeneration

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Corticobasal Degeneration family:

Corticobasal Degeneration, Mapt-Related

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1progressive supranuclear palsy31.6RPS27A, SNCA, HCRT, MAPT
2dementia31.1HCRT, TARDBP, GBA, MAPK3, SNCA, RPS27A
3frontotemporal dementia31.0TARDBP, SNCA, MAPT, RPS27A
4alzheimer's disease31.0MAPK1, HCRT, TARDBP, HRAS, HMOX1, MAPK3
5pick's disease31.0RPS27A, SNCA, MAPT, TARDBP
6aphasia31.0MAPT, TARDBP
7parkinson's disease30.8MAPK3, SNCA, RPS27A, CASP3, GBA, MAPT
8tauopathy30.8MAPT, RPS27A, SNCA
9multiple system atrophy30.7SNCA, MAPT, RPS27A
10brain disease30.6HCRT, MAPT, SNCA
11lewy body dementia30.5RPS27A, SNCA, MAPT
12motor neuron disease30.4RPS27A, SNCA, MAPT, TARDBP
13rem sleep behavior disorder30.3SNCA
14lateral sclerosis30.3MAPT, SNCA
15amyotrophic lateral sclerosis30.3TARDBP, MAPT, SNCA, CASP3, HSPB2, RPS27A
16huntington's disease30.1CASP3
17pulmonary fibrosis30.1HMOX1
18creutzfeldt-jakob syndrome30.1RPS27A, SNCA, MAPT
19striatonigral degeneration30.1SNCA, RPS27A
20movement disease30.1MAPT, RPS27A, SNCA
21apraxia10.8
22cerebritis10.7
23cerebral degeneration10.7
24neuronitis10.6
25cerebral palsy10.4
26basal ganglia disease10.2
27sleep disorder10.2
28corticobasal degeneration, mapt-related10.2
29parametritis10.1
30antiphospholipid syndrome10.1
31olivopontocerebellar atrophy10.1
32arachnoiditis10.1
33ideomotor apraxia10.1
34complex regional pain syndrome10.1
35image syndrome10.1
36hereditary diffuse leukoencephalopathy with spheroids10.1
37multiple sclerosis10.0HCRT
38endometriosis10.0RPS27A
39neuronal intranuclear inclusion disease10.0RPS27A
40pancreatitis10.0HRAS
41bladder carcinoma10.0HRAS
42cerebral amyloid angiopathy10.0MAPT
43tuberculosis10.0PRDX5
44hepatitis b10.0HRAS
45cystic fibrosis10.0HMOX1
46neuroblastoma10.0MYC
47transient cerebral ischemia10.0RPS27A
48myopathy10.0HSPB2, RPS27A
49semantic dementia10.0MAPT, RPS27A
50brain ischemia10.0MAPK3, MAPT

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to corticobasal degeneration

Clinical Features for Corticobasal Degeneration

About this section

Drugs & Therapeutics for Corticobasal Degeneration

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Corticobasal Degeneration

Drug clinical trials:

Search ClinicalTrials for Corticobasal Degeneration

Search NIH Clinical Center for Corticobasal Degeneration

Search CenterWatch for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

About this section

Anatomical Context for Corticobasal Degeneration

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Corticobasal Degeneration:

32
Cortex, Brain

Animal Models for Corticobasal Degeneration or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Corticobasal Degeneration

About this section

Genetic Variations for Corticobasal Degeneration

About this section

Expression for genes affiliated with Corticobasal Degeneration

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for genes affiliated with Corticobasal Degeneration

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 49PharmGKB, 59Tocris Bioscience
See all sources

Pathways related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MAPK1, HRAS, MAPK3
2
Hide members
9.5MAPK1, HRAS, MAPK3
3
Hide members
9.5MAPK3, HRAS, MAPK1
4
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.5HRAS, MAPK3, MAPK1
5
Immune response IL-6 signaling pathway
Hide members
9.5MAPK3, MAPK1, HRAS
69.5MAPK3, MAPK1, HRAS
79.5MAPK1, MAPK3, SNCA
8
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
Hide members
9.4MYC, MAPK1, MAPK3
9
Hide members
9.3MAPK3, RPS27A, HRAS, MAPK1
10
Hide members
9.3RPS27A, HRAS, MAPK1, MAPK3
11
Development A3 receptor signaling
Hide members
9.2MYC, MAPK1, MAPK3, HRAS
12
Immune response IL-2 activation and signaling pathway
Hide members
9.2MYC, MAPK1, MAPK3, HRAS
13
Hide members
9.2HRAS, MYC, MAPK3, MAPK1
14
Hide members
9.2MYC, MAPK1, HRAS, MAPK3
159.2HRAS, MYC, MAPK1, MAPK3
16
Development PDGF signaling via STATs and NF-kB
Hide members
9.2MYC, MAPK3, MAPK1, HRAS
17
Hide members
9.2HRAS, MAPK1, MYC, MAPK3
189.2MAPK3, MAPK1, MYC, HRAS
199.2MAPK3, MAPK1, MYC, HRAS
20
Development EPO-induced Jak-STAT pathway
Hide members
9.2MAPK1, MAPK3, HRAS, MYC
219.2MAPK1, CASP3, MAPK3, HRAS
22
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.2HRAS, MAPK1, MAPK3, CASP3
23
Hide members
9.2HRAS, MAPK1, MAPK3, CASP3
24
Hide members
9.2CASP3, MAPK3, MAPK1, HRAS
259.1MAPK3, MYC, CASP3, MAPK1
26
Hide members
9.0HRAS, MAPT, MYC, MAPK1, MAPK3
279.0MAPK1, MAPK3, CFL1
289.0MAPK3, MAPK1, MAPT, CASP3, HRAS
298.9HRAS, MAPK1, SNCA, MAPK3, MYC
308.9CASP3, MAPK3, MAPT, MYC, MAPK1
318.8HRAS, MYC, MAPK1, MAPK3, CASP3
32
Development Prolactin receptor signaling
Hide members
8.8MAPK1, CASP3, HRAS, MYC, MAPK3
33
Hide members
8.8MYC, CASP3, MAPK3, MAPK1, HRAS
34
Hide members
8.8CASP3, MAPK1, MYC, HRAS, MAPK3
35
Hide members
8.8HRAS, MYC, MAPK3, CASP3, MAPK1
36
Hide members
8.8MAPK3, MAPK1, MYC, HRAS, CASP3
37
Hide members
8.8CASP3, MYC, MAPK1, HRAS, MAPK3
38
Hide members
8.8MAPK1, CASP3, MYC, HRAS, MAPK3
398.8MAPK1, MYC, HRAS, HMOX1, CASP3
40
Hide members
8.7CFL1, HRAS, MAPK1, MAPK3
418.7HRAS, MAPK1, CFL1, MAPK3
42
Hide members
8.6MAPK1, HRAS, CASP3, MAPK3, SNCA, MAPT
438.6CFL1, MAPK1, MAPK3, CASP3
44
Hide members
8.3MAPK1, HRAS, CASP3, MAPK3, CFL1
458.3MYC, HSPB2, CASP3, MAPK3, MAPK1, HRAS
468.1CASP3, MAPT, MAPK1, HRAS, CFL1, MAPK3
47
Hide members
8.1MAPK3, HRAS, MYC, HSPB2, CASP3, MAPK1
48
Hide members
8.0MAPK1, CASP3, MYC, MAPK3, CFL1, HRAS
49
Hide members
7.8CFL1, MAPK3, CSF3, MAPK1, CASP3, HRAS
50
Hide members
7.8CASP3, MAPK1, MAPK3, MYC, HRAS, CFL1

Compounds for genes affiliated with Corticobasal Degeneration

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7MAPT
2butyrate4410.4RPS27A, MAPT
3thioflavine s4410.1RPS27A, SNCA, MAPT
4rotenone4410.0SNCA, HMOX1, RPS27A
5pge2449.9HRAS, SNCA
6thapsigargin44 5910.8MAPK3, CASP3, HCRT
7nmda44 2810.6RPS27A, MAPK3, MAPT, HCRT, HRAS
8resveratrol44 59 11 2412.6MAPK3, HMOX1, PRDX5
9formate449.5SNCA, RPS27A, MAPT, PRDX5
10radicicol44 59 1111.4HSPB2, MAPK3, RPS27A, MAPK1
11c2ceramide449.4MAPK3, MAPT, MAPK1, CASP3
126-hydroxydopamine449.3SNCA, MYC, CASP3, RPS27A, HMOX1
13dexamethasone44 49 28 1112.3MYC, MAPK1, MAPK3, HCRT
14roscovitine449.3MAPT, MAPK1, CASP3, MYC, MAPK3
15herbimycin a44 5910.3MAPK1, HRAS, MYC, MAPK3, RPS27A
16rottlerin449.2MAPK1, HMOX1, MAPK3, CASP3
17ly294002449.2MAPK3, MYC, HMOX1, MAPK1, HRAS
18sp 60012544 5910.2CASP3, SNCA, MAPK3, HMOX1, MAPK1
19valine449.2SNCA, RPS27A, MAPT, HRAS, CSF3
20serine449.1MAPT, HRAS, SNCA, GBA, HSPB2
21sulforaphane449.1HMOX1, PRDX5, CASP3, MAPK1
22acetylcholine44 49 28 11 2413.0HCRT, MAPT, HMOX1, SNCA, HSPB2, RPS27A
2315-deoxy-delta-12,14-prostaglandin j2448.9CASP3, MAPK1, HMOX1, MYC
24quercetin44 59 11 2411.9HSPB2, CASP3, MAPK3, HMOX1, MAPK1
25melphalan44 119.9MAPK3, PRDX5, MYC, CSF3
26actinomycin d448.9MAPK1, HMOX1, MYC, CASP3, RPS27A, MAPT
27imatinib44 49 1110.9MYC, MAPK1, CSF3, CASP3, RPS27A
28genistein44 28 59 2 11 2413.8CASP3, MAPK3, MAPK1, HRAS, MYC, MAPT
29lactacystin448.7RPS27A, CASP3, MAPK1, SNCA, MAPT, MYC
30mg 13244 599.7RPS27A, CASP3, MAPT, MAPK1, MYC, HMOX1
31paclitaxel44 49 1110.7MAPK1, CASP3, MAPK3, MYC, HRAS, CSF3
32daunorubicin44 49 1110.7MAPK3, CSF3, CASP3, MYC
33rapamycin448.6SNCA, HRAS, MYC, MAPK1, CASP3, RPS27A
34sb 20358044 599.6HMOX1, SNCA, MAPK1, MAPK3, CASP3, HSPB2
35pd 98,059448.6MAPK3, CASP3, HSPB2, MAPK1, HRAS, MYC
36arsenite44 249.4HMOX1, MYC, MAPK3, CASP3, HSPB2, RPS27A
37curcumin448.3PRDX5, MYC, MAPK1, MAPK3, CASP3, RPS27A
38glutamine448.3RPS27A, HSPB2, SNCA, PRDX5, MAPT, HRAS
39oxygen44 249.3HSPB2, HMOX1, HRAS, GBA, PRDX5, SNCA
40doxorubicin44 49 1110.1RPS27A, CSF3, MAPT, MYC, HRAS, HMOX1
414-hydroxynonenal44 249.1MAPT, RPS27A, MYC, MAPK1, PRDX5, SNCA
42cyclosporin a44 28 5910.0RPS27A, MYC, HRAS, CASP3, CSF3, PRDX5
43nitric oxide44 11 2410.0SNCA, HRAS, GBA, MAPK1, MAPK3, PRDX5
44n acetylcysteine447.8MAPT, PRDX5, HMOX1, MAPK3, SNCA, CASP3
45cysteine447.8HMOX1, GBA, MAPT, RPS27A, MAPK3, PRDX5
46vegf447.6HSPB2, HRAS, MYC, MAPK1, CSF3, MAPK3
47superoxide44 248.5HSPB2, CSF3, PRDX5, TARDBP, CASP3, CFL1
48h2o2447.4HRAS, MAPT, MAPK3, RPS27A, HSPB2, SNCA
49retinoic acid44 248.3HMOX1, MAPK3, RPS27A, CSF3, PRDX5, MAPT
50cisplatin44 49 59 1110.0HSPB2, RPS27A, PRDX5, MAPK3, MAPK1, HMOX1

GO Terms for genes affiliated with Corticobasal Degeneration

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Corticobasal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pseudopodiumGO:0311439.8MAPK1, MAPK3
2caveolaGO:0059019.4MAPK3, MAPK1, HMOX1
3cytosolGO:0058296.7HMOX1, RPS27A, HSPB2, CASP3, SNCA, PRDX5
4nucleusGO:0056345.7HSPB2, CASP3, SNCA, PRDX5, MAPK3, MAPK1

Biological processes related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1regulation of Golgi inheritanceGO:09017010.2MAPK1, MAPK3
2regulation of early endosome to late endosome transportGO:200064110.2MAPK1, MAPK3
3caveolin-mediated endocytosisGO:07258410.2MAPK3, MAPK1
4response to epidermal growth factor stimulusGO:07084910.2MAPK3, MAPK1
5regulation of stress-activated MAPK cascadeGO:03287210.1MAPK1, MAPK3
6positive regulation of actin cytoskeleton reorganizationGO:200025110.0HRAS, CSF3
7activation of MAPKK activityGO:0001869.9MAPK3, MAPK1, HRAS
8stress-activated MAPK cascadeGO:0514039.9RPS27A, MAPK3, MAPK1
9toll-like receptor 10 signaling pathwayGO:0341669.9RPS27A, MAPK3, MAPK1
10toll-like receptor 5 signaling pathwayGO:0341469.9RPS27A, MAPK3, MAPK1
11regulation of sequence-specific DNA binding transcription factor activityGO:0510909.9MAPK3, MAPK1, HMOX1
12toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.9RPS27A, MAPK3, MAPK1
13toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.9RPS27A, MAPK3, MAPK1
14toll-like receptor 9 signaling pathwayGO:0341629.9RPS27A, MAPK3, MAPK1
15toll-like receptor 2 signaling pathwayGO:0341349.9RPS27A, MAPK3, MAPK1
16TRIF-dependent toll-like receptor signaling pathwayGO:0356669.8RPS27A, MAPK3, MAPK1
17Ras protein signal transductionGO:0072659.8MAPK3, MAPK1, HRAS
18MyD88-independent toll-like receptor signaling pathwayGO:0027569.8MAPK1, MAPK3, RPS27A
19toll-like receptor 3 signaling pathwayGO:0341389.8RPS27A, MAPK3, MAPK1
20MyD88-dependent toll-like receptor signaling pathwayGO:0027559.8RPS27A, MAPK3, MAPK1
21regulation of cytoskeleton organizationGO:0514939.8MAPK1, MAPK3
22organ morphogenesisGO:0098879.8MAPK3, MAPK1, HRAS
23activation of MAPK activityGO:0001879.7RPS27A, MAPK3, MAPK1
24fibroblast growth factor receptor signaling pathwayGO:0085439.7RPS27A, MAPK3, MAPK1, HRAS
25toll-like receptor 4 signaling pathwayGO:0341429.7RPS27A, MAPK3, MAPK1
26Fc-epsilon receptor signaling pathwayGO:0380959.7HRAS, MAPK1, MAPK3, RPS27A
27negative regulation of neuron apoptotic processGO:0435249.7SNCA, HRAS, HMOX1
28epidermal growth factor receptor signaling pathwayGO:0071739.7HRAS, MAPK1, MAPK3, RPS27A
29MAPK cascadeGO:0001659.6HRAS, MYC, MAPK1, MAPK3
30response to DNA damage stimulusGO:0069749.5MYC, MAPK1, MAPK3, CASP3
31neurotrophin TRK receptor signaling pathwayGO:0480119.3HRAS, MAPK1, MAPK3, CASP3, RPS27A
32toll-like receptor signaling pathwayGO:0022249.2MAPK1, MAPK3, RPS27A
33Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.2CFL1, MAPK1, MAPK3
34small GTPase mediated signal transductionGO:0072649.1MAPK3, MAPK1, HRAS, HMOX1
35apoptotic processGO:0069159.1MAPK1, MAPT, MAPK3, CASP3, RPS27A
36axon guidanceGO:0074118.7CFL1, HRAS, MAPK1, MAPK3
37innate immune responseGO:0450878.6CFL1, HRAS, MAPK1, MAPK3, RPS27A
38negative regulation of apoptotic processGO:0430668.2RPS27A, CASP3, SNCA, PRDX5, MYC, CFL1

Molecular functions related to Corticobasal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphotyrosine bindingGO:0017849.8MAPK1, MAPK3
2MAP kinase activityGO:0047079.5MAPK1, MAPK3

Products for genes affiliated with Corticobasal Degeneration

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corticobasal Degeneration

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet