Corticobasal Degeneration malady

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UMLS65 C0393570

NINDS:⁴⁶ Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards based summary: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to tauopathy and corticobasal degeneration, mapt-related. An important gene associated with Corticobasal Degeneration is MAPT (Microtubule Associated Protein Tau), and among its related pathways are Arf6 signaling events and Malaria. Affiliated tissues include cortex, brain and liver, and related mouse phenotypes are no phenotypic analysis and integument.

NIH Rare Diseases:⁴⁵ Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/14/2015

Wikipedia:⁶⁸ Corticobasal degeneration (CBD) or corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

Search GEO for disease gene expression data for Corticobasal Degeneration.