Corticobasal Degeneration disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Corticobasal Degeneration

Sources:
⁴²NIH Rare Diseases, ⁴³NINDS, ⁶⁴Wikipedia, ³²MalaCards
See all sources

NINDS:⁴³ Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards based summary: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to progressive supranuclear palsy and aphasia. An important gene associated with Corticobasal Degeneration is MAPT (microtubule-associated protein tau), and among its related pathways are MNAR-PELP1 and Estrogen Receptor Interaction and Development Leptin signaling via JAK STAT and MAPK cascades. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and eye, and related mouse phenotypes are taste/olfaction and tumorigenesis.

NIH Rare Diseases:⁴² Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/4/2010

Wikipedia:⁶⁴ Corticobasal degeneration (CBD) or Corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

Aliases & Classifications for Corticobasal Degeneration

Sources:
⁴²NIH Rare Diseases, ⁴³NINDS, ⁴⁸Orphanet, ⁶¹UMLS, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet
See all sources

Corticobasal Degeneration, Aliases & Descriptions:

Name: Corticobasal Degeneration ⁴² ⁴³ ⁴⁸ ⁶¹

Cortical-Basal Ganglionic Degeneration ⁴²

Cortical Basal Ganglionic Degeneration ⁶¹

Cortico-Basal Ganglionic Degeneration ⁴²

Cbgd ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases

ICD10: ²⁷

Diseases of the nervous system

Other degenerative diseases of the nervous system

Other degenerative diseases of nervous system, not elsewhere classified

Circumscribed brain atrophy

Orphanet: ⁴⁸

Rare neurological diseases

Characteristics (Orphanet epidemiological data):

⁴⁸

corticobasal degeneration:
Prevalence: 1-9/100000; Age of onset: Adulthood

External Ids:

ICD10 via Orphanet²⁷ G31.0

UMLS via Orphanet⁶² C0393570

Related Diseases for Corticobasal Degeneration

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Corticobasal Degeneration family:

Corticobasal Degeneration, Mapt-Related

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 108)

id	Related Disease	Score	Top Affiliating Genes
1	progressive supranuclear palsy	32.0	HCRT, SNCA, RPS27A, MAPT
2	aphasia	31.6	TARDBP, MAPT
3	primary progressive aphasia	31.6	MAPT, RPS27A
4	frontotemporal dementia	31.4	TARDBP, MAPT, RPS27A, SNCA
5	pick's disease	31.4	TARDBP, MAPT, RPS27A, SNCA
6	tauopathy	31.4	SNCA, RPS27A, MAPT
7	semantic dementia	31.3	RPS27A, MAPT
8	multiple system atrophy	31.2	MAPT, RPS27A, SNCA
9	creutzfeldt-jakob disease	31.2	SNCA, RPS27A, MAPT
10	rem sleep behavior disorder	31.1	SNCA
11	dementia	31.0	GBA, HCRT, SNCA, RPS27A, MAPT, MAPK3
12	lateral sclerosis	31.0	SNCA, MAPT
13	parkinson's disease	30.9	GBA, PITX3, SNCA, RPS27A, MAPT
14	normal pressure hydrocephalus	30.9	HCRT, MAPT
15	motor neuron disease	30.8	SNCA, RPS27A, MAPT, TARDBP
16	huntington's disease	30.8	CASP3
17	striatonigral degeneration	30.7	SNCA, RPS27A
18	alzheimer's disease	29.4	HRAS, HCRT, HSPB2, PRDX5, TARDBP, HMOX1
19	apraxia	10.9
20	cerebritis	10.7
21	neuronitis	10.6
22	myoclonus	10.6
23	neuronal intranuclear inclusion disease	10.6	RPS27A
24	hypersplenism	10.4	GBA
25	dystonia	10.4
26	inclusion body myositis	10.4	MAPT, RPS27A
27	parkinson disease 1	10.4	SNCA
28	myotonic dystrophy	10.4	MAPT, HSPB2, HCRT
29	neuroblastoma	10.4	MYC
30	parkinson disease type 3	10.4	SNCA, MAPT
31	neuroaxonal dystrophy	10.3	SNCA, RPS27A
32	hemiparkinsonism-hemiatrophy syndrome	10.3
33	central nervous system disease	10.3	HCRT, MAPT, HMOX1
34	niemann-pick disease type c1	10.3	MAPT, SNCA, HCRT
35	lewy body dementia	10.3	MAPT, RPS27A, SNCA
36	vascular dementia	10.3	SNCA, RPS27A, MAPT
37	spinocerebellar ataxia	10.3	MAPT, RPS27A, SNCA
38	amyotrophic lateral sclerosis	10.3
39	corticobasal degeneration, mapt-related	10.3
40	movement disease	10.3	MAPT, RPS27A, SNCA
41	myositis	10.3	MAPT, RPS27A, SNCA
42	brain disease	10.3	HCRT, SNCA, MAPT
43	amyloidosis	10.3	MAPT, RPS27A, SNCA
44	machado-joseph disease	10.2	SNCA, RPS27A
45	pancytopenia	10.2	GBA, CSF3
46	hydrocephalus	10.1
47	pulmonary fibrosis	10.1
48	olivopontocerebellar atrophy	10.1
49	neuroleptic malignant syndrome	10.1
50	parametritis	10.1

Graphical network of the top 20 diseases related to Corticobasal Degeneration:

Symptoms for Corticobasal Degeneration

Drugs & Therapeutics for Corticobasal Degeneration

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Corticobasal Degeneration

Search NIH Clinical Center for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

Anatomical Context for Corticobasal Degeneration

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Corticobasal Degeneration:

³²

Cortex, Brain, Eye, Spinal cord, Thalamus

Animal Models for Corticobasal Degeneration or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Corticobasal Degeneration:

³⁶ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.2	SNCA, MAPK1, MAPT, CASP3
2	tumorigenesis	MP:0002006	8.7	MYC, MAPK1, MAPT, MAPK3, HRAS
3	endocrine/exocrine gland phenotype	MP:0005379	8.4	HRAS, HMOX1, CASP3, SNCA, MYC, PITX3
4	liver/biliary system phenotype	MP:0005370	8.3	GBA, PITX3, MYC, MAPK1, MAPK3, HMOX1
5	respiratory system phenotype	MP:0005388	8.1	GBA, PITX3, HCRT, MAPK1, MAPK3, CASP3
6	muscle phenotype	MP:0005369	7.8	HCRT, HSPB2, MYC, MAPK1, MAPT, MAPK3
7	skeleton phenotype	MP:0005390	7.8	GBA, PITX3, HSPB2, MYC, SNCA, CASP3
8	renal/urinary system phenotype	MP:0005367	7.7	CFL1, SNCA, MAPT, CSF3, CASP3, HMOX1
9	no phenotypic analysis	MP:0003012	7.6	PITX3, CFL1, MYC, SNCA, MAPT, CASP3
10	hematopoietic system phenotype	MP:0005397	7.2	GBA, PITX3, MYC, MAPK1, MAPT, MAPK3
11	cardiovascular system phenotype	MP:0005385	6.7	GBA, HCRT, CFL1, HSPB2, MYC, SNCA
12	immune system phenotype	MP:0005387	6.5	SNCA, MYC, HSPB2, PITX3, GBA, MAPK1
13	integument phenotype	MP:0010771	6.5	GBA, PITX3, CFL1, MYC, SNCA, MAPK1
14	homeostasis/metabolism phenotype	MP:0005376	6.4	MYC, CFL1, HCRT, PITX3, GBA, SNCA
15	mortality/aging	MP:0010768	6.4	SNCA, MYC, HSPB2, CFL1, GBA, MAPK1
16	cellular phenotype	MP:0005384	6.2	MYC, HSPB2, CFL1, PITX3, GBA, SNCA
17	nervous system phenotype	MP:0003631	6.1	HSPB2, CFL1, HCRT, PITX3, GBA, MYC
18	behavior/neurological phenotype	MP:0005386	5.8	HRAS, GBA, PITX3, HCRT, CFL1, HSPB2
19	growth/size/body phenotype	MP:0005378	5.8	MYC, HSPB2, CFL1, HCRT, PITX3, GBA

Publications for Corticobasal Degeneration

Sources:
⁵¹PubMed
See all sources

Articles related to Corticobasal Degeneration:

(show top 50) (show all 377)

id	Title	Authors	Year
1	A disease-specific metabolic brain network associated with corticobasal degeneration. (25208922)	Niethammer M.... Eidelberg D.	2014
2	Argyrophilic grains are reliable disease-specific features of corticobasal degeneration. (24335531)	Tatsumi S.... Yoshida M.	2014
3	Analysis of PITX3 gene in patients with multisystem atrophy, progressive supranuclear palsy and corticobasal degeneration. (23694789)	Jamrozik Z.... Kwiecinski H.	2013
4	A case of an arachnoid cyst masquerading as corticobasal degeneration. (23061395)	Dunn C.B.... Wagle Shukla A.A.	2012
5	A case of Creutzfeldt-Jakob disease mimicking corticobasal degeneration: FDG PET, SPECT, and MRI findings. (22691528)	Zhang Y.... Lewis D.H.	2012
6	Acalculia in autopsy-proven corticobasal degeneration. (21321355)	Pantelyat A.... Grossman M.	2011
7	Seizures in corticobasal degeneration: a case report. (19544144)	Douglas V.C.... Rabinovici G.D.	2009
8	Clinicopathological and genetic correlates of frontotemporal lobar degeneration and corticobasal degeneration. (18357425)	LladA^ A.... Molinuevo J.L.	2008
9	Corticobasal degeneration: clinical aspects. (18631773)	Bak T.H.... Hodges J.R.	2008
10	Dysfunctional facial emotional expression and comprehension in a patient with corticobasal degeneration. (17786775)	Kluger B.M.... Heilman K.M.	2007
11	Co-occurrence of radiological features of progressive supranuclear palsy and corticobasal degeneration. (17272907)	Divatia R.... Kishore A.	2007
12	Rapid eye movement (REM) sleep without atonia in two patients with corticobasal degeneration (CBD). (17055327)	Gatto E.M.... HAPgl B.	2007
13	Corticobasal degeneration. (18808957)	Stover N.P.... Watts R.L.	2007
14	The clinical overlap between the corticobasal degeneration syndrome and other diseases of the frontotemporal spectrum: three case reports. (17726244)	Raggi A.... Cappa S.F.	2007
15	Sporadic SCA8 mutation resembling corticobasal degeneration. (15823478)	Baba Y.... Wszolek Z.K.	2005
16	Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases. (15735950)	Tsuchiya K.... Mizusawa H.	2005
17	Creutzfeldt-Jakob disease mimicking corticobasal degeneration clinical and MRI data of a case. (15795791)	Moreaud O.... Lebas J.F.	2005
18	Neurosyphilis masquerading as corticobasal degeneration. (15389980)	Benito-LeA^n J.... Louis E.D.	2004
19	Rapid onset of pergolide-induced pulmonary fibrosis in a patient with corticobasal degeneration. (15222217)	Simcock D.... Paviour D.	2004
20	Corticobasal degeneration syndrome with basal ganglia calcification: Fahr's disease as a corticobasal look-alike? (12621646)	Lang A.E.	2003
21	Limb-kinetic apraxia in corticobasal degeneration: clinical and kinematic features. (12518300)	Leiguarda R.C.... NoguAcs M.	2003
22	Cholinergic neuronal loss in the basal forebrain and mesopontine tegmentum of progressive supranuclear palsy and corticobasal degeneration. (12536222)	Kasashima S.... Oda Y.	2003
23	Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction. (14581681)	Tang-Wai D.F.... Petersen R.C.	2003
24	Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration. (12084445)	Hosaka K.... Mori E.	2002
25	Unilateral periodic limb movements during sleep in corticobasal degeneration. (11748759)	Iriarte J.... de Castro P.	2001
26	Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy. (11303763)	Arai T.... Takamatsu J.	2001
27	Rhythmic cortical and muscle discharges induced by fatigue in corticobasal degeneration. (10699413)	Manto M.U.... Seeldrayers P.	2000
28	Phenotypes and prognosis: clinicopathologic studies of corticobasal degeneration. (10624482)	Litvan I.... Lang A.E.	2000
29	Aphasia in corticobasal degeneration. (10624476)	Black S.E.	2000
30	Immunohistochemistry distinguishes: between Pick's disease and corticobasal degeneration. (11185644)	Bell K.... Rossor M.N.	2000
31	Neuropsychiatric aspects of corticobasal degeneration. (10624478)	Cummings J.L.... Litvan I.	2000
32	The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. (11087783)	Kertesz A.... Munoz D.G.	2000
33	Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease. (10965796)	Sakurai A.... Gonatas N.K.	2000
34	Cerebral blood flow in corticobasal degeneration and progressive supranuclear palsy. (10718204)	Okuda B.... Sugita M.	2000
35	Contribution of PET studies in diagnosis of corticobasal degeneration. (10894990)	Lutte I.... De Volder A.	2000
36	Cognitive and magnetic resonance imaging aspects of corticobasal degeneration and progressive supranuclear palsy. (10449111)	Soliveri P.... Girotti F.	1999
37	Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms. (10037497)	Sergeant N.... Delacourte A.	1999
38	A comparison of tau protein in cerebrospinal fluid between corticobasal degeneration and progressive supranuclear palsy. (10025574)	Urakami K.... Nakashima K.	1999
39	Heterogeneity of glucose metabolism in corticobasal degeneration. (9879684)	Taniwaki T.... Kira J.	1998
40	Neuropsychological and neuroimaging correlates in corticobasal degeneration. (10933454)	Frasson E.... Rizzuto N.	1998
41	Increased CSF tau protein in corticobasal degeneration. (9457628)	Mitani K.... Mori H.	1998
42	Paired helical filaments in corticobasal degeneration: the fine fibrillary structure with NanoVan. (9409702)	Tracz E.... Ksiezak-Reding H.	1997
43	Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy. (8702002)	Ksiezak-Reding H.... Wall J.S.	1996
44	Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy. (7572077)	Feany M.B.... Dickson D.W.	1995
45	Unique myoclonic pattern in corticobasal degeneration. (7753055)	Brunt E.R.... Lakke J.W.	1995
46	Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy. (7985491)	Mori H.... Oda M.	1994
47	Unusual case of corticobasal degeneration with tau/Gallyas-positive neuronal and glial tangles. (7879609)	Horoupian D.S.... Chu P.L.	1994
48	Corticobasal degeneration: a report of three cases. (8046710)	Muhiddin K.A.... Kirby B.J.	1994
49	Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy. (7526285)	Ikeda K.... Oda T.	1994
50	Corticobasal degeneration: decreased and asymmetrical glucose consumption as studied with PET. (1484530)	Blin J.... Agid Y.	1992

Genes related to Corticobasal Degeneration

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Corticobasal Degeneration:

(show all 18)

- Elite gene

id	Symbol	Description	Score	Implication
1	MAPT	microtubule-associated protein tau	20.56	GeneCards inferred via : Publications, Disorders (show sections)
2	HCRT	hypocretin (orexin) neuropeptide precursor	19.45	GeneCards inferred via : Publications (show sections)
3	PGAM1	phosphoglycerate mutase 1 (brain)	18.33	GeneCards inferred via : Publications (show sections)
4	RPS27A	ribosomal protein S27a	17.22	GeneCards inferred via : Publications (show sections)
5	GBA	glucosidase, beta, acid	16.11	GeneCards inferred via : Publications (show sections)
6	TARDBP	TAR DNA binding protein	15.00	GeneCards inferred via : Publications (show sections)
7	HRAS	Harvey rat sarcoma viral oncogene homolog	13.89	GeneCards inferred via : Publications (show sections)
8	HMOX1	heme oxygenase (decycling) 1	12.78	GeneCards inferred via : Publications (show sections)
9	MAPK3	mitogen-activated protein kinase 3	11.67	GeneCards inferred via : Publications (show sections)
10	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	10.56	GeneCards inferred via : Publications (show sections)
11	MYC	v-myc avian myelocytomatosis viral oncogene homolog	9.45	GeneCards inferred via : Publications (show sections)
12	CASP3	caspase 3, apoptosis-related cysteine peptidase	8.33	GeneCards inferred via : Publications (show sections)
13	MAPK1	mitogen-activated protein kinase 1	7.22	GeneCards inferred via : Publications (show sections)
14	PITX3	paired-like homeodomain 3	5.62	GeneCards inferred via : Publications (show sections)
15	HSPB2	heat shock 27kDa protein 2	5.00	GeneCards inferred via : Publications (show sections)
16	PRDX5	peroxiredoxin 5	3.89	GeneCards inferred via : Publications (show sections)
17	CFL1	cofilin 1 (non-muscle)	2.78	GeneCards inferred via : Publications (show sections)
18	CSF3	colony stimulating factor 3 (granulocyte)	1.67	GeneCards inferred via : Publications (show sections)

Products for genes related to Corticobasal Degeneration disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	18	-	18	18
2	Novus Biologicals	16	18	18	-

Variations for Corticobasal Degeneration

Expression for genes affiliated with Corticobasal Degeneration

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for genes affiliated with Corticobasal Degeneration

Sources:
⁴⁹PathCards, ⁵²QIAGEN, ⁵⁹Thomson Reuters, ⁵⁴Reactome, ³⁷NCBI BioSystems Database, ¹³EMD Millipore, ³⁰KEGG, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience
See all sources

Pathways related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50) (show all 162)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	MNAR-PELP1 and Estrogen Receptor Interaction⁵²	9.5	HRAS, MAPK3, MAPK1
2	Development Leptin signaling via JAK STAT and MAPK cascades⁵⁹ Show member pathways phospho-PLA2 pathway⁵⁴	9.5	HRAS, MAPK3, MAPK1
3	Nongenotropic Androgen signaling³⁷	9.5	MAPK1, MAPK3, HRAS
4	Apoptosis and survival Anti apoptotic action of nuclear ESR1 and ESR2⁵⁹	9.4	MAPK1, MAPK3, MYC
5	EphB-EphrinB Signaling⁵² Show member pathways Ephrin-Eph Signaling⁵² Cytoskeleton remodeling Reverse signaling by ephrin B⁵⁹	9.3	MAPK1, MAPT, MAPK3, HRAS
6	FGFR ligand binding and activation⁵⁴ Show member pathways FGFR1c and Klotho ligand binding and activation⁵⁴ Signaling by FGFR2 amplification mutants⁵⁴ Klotho-mediated ligand binding⁵⁴ FGFR2 ligand binding and activation⁵⁴ Negative regulation of FGFR signaling⁵⁴ FRS2-mediated cascade⁵⁴ Signaling by FGFR1 amplification mutants⁵⁴ FGFR1b ligand binding and activation⁵⁴ SHC-mediated cascade⁵⁴ FGFR4 ligand binding and activation⁵⁴ betaKlotho-mediated ligand binding⁵⁴ Signaling by FGFR2 mutants⁵⁴ Signaling by FGFR4 mutants⁵⁴ Development FGF family signaling⁵⁹ FGFR1 ligand binding and activation⁵⁴ Spry regulation of FGF signaling⁵⁴ FGFR2c ligand binding and activation⁵⁴ FGFR2b ligand binding and activation⁵⁴ Activated point mutants of FGFR2⁵⁴	9.3	MAPK3, RPS27A, HRAS, MAPK1
7	Development IGF 1 receptor signaling⁵⁹ Show member pathways Development IGF RI signaling¹³ Immune response IL 4 signaling pathway⁵⁹ Signal transduction AKT signaling⁵⁹	9.2	HRAS, MAPK3, MAPK1, MYC
8	Immune response IL 2 activation and signaling pathway⁵⁹ Show member pathways Immune response IL 3 activation and signaling pathway⁵⁹	9.2	HRAS, MAPK1, MYC, MAPK3
9	Immune response IL 23 signaling pathway⁵⁹ Show member pathways IL23-mediated signaling events³⁷ Angiopoietin-TIE2 Signaling⁵² Immune response IL 10 signaling pathway⁵⁹ Angiopoietin receptor Tie2-mediated signaling³⁷ Development PDGF signaling via STATs and NF kB⁵⁹ Development Angiopoietin Tie2 signaling⁵⁹	9.2	MAPK3, MAPK1, HRAS, MYC
10	Thyroid hormone signaling pathway³⁰	9.2	HRAS, MAPK1, MAPK3, MYC
11	Glioblastoma Multiforme⁵²	9.2	MAPK1, HRAS, MAPK3, MYC
12	Development EPO induced Jak STAT pathway⁵⁹ Show member pathways EPO Receptor Signaling³⁷ EPO signaling pathway³⁷	9.2	HRAS, MYC, MAPK1, MAPK3
13	TSH signaling pathway³⁷	9.2	MAPK3, MAPK1, MYC, HRAS
14	Development A3 receptor signaling⁵⁹ Show member pathways Development A1 receptor signaling⁵⁹ G protein signaling G Protein alpha q signaling cascades⁵⁹	9.2	MYC, MAPK1, HRAS, MAPK3
15	ErbB signaling pathway³⁰ Show member pathways ErbB receptor signaling network³⁷ ErbB signaling pathway³⁷ EGFR Inhibitor Pathway, Pharmacodynamics⁵⁰	9.2	MYC, MAPK1, MAPK3, HRAS
16	Thyroid cancer³⁰	9.2	MAPK3, HRAS, MYC, MAPK1
17	Chronic myeloid leukemia³⁰ Show member pathways Pancreatic cancer³⁰	9.2	HRAS, MAPK3, MYC, MAPK1
18	UVA-Induced MAPK Signaling⁵² Show member pathways UVB-Induced MAPK Signaling⁵²	9.1	HRAS, MAPK3, CASP3, MAPK1
19	G protein signaling Ras family GTPases in kinase cascades scheme ⁵⁹ Show member pathways MAPK Cascade³⁷ Immune response Oncostatin M signaling via MAPK in human cells⁵⁹ Oncostatin M Signaling Pathway³⁷ Activation of the AP-1 family of transcription factors⁵⁴	9.1	HRAS, CASP3, MAPK3, MAPK1
20	Ceramide Pathway⁵² Show member pathways TNF-Induced Apoptosis Implicating Sphingolipids⁵²	9.1	HRAS, MAPK1, MAPK3, CASP3
21	Syndecan-2-mediated signaling events³⁷	9.1	MAPK3, CASP3, HRAS, MAPK1
22	Spinal Cord Injury³⁷	9.0	MYC, MAPK3, CASP3, MAPK1
23	IL2-mediated signaling events³⁷ Show member pathways IL-2 Signaling pathway³⁷	9.0	MAPT, MAPK1, MYC, HRAS, MAPK3
24	IL-6 Signaling Pathway³⁷	8.9	HRAS, MAPT, MAPK1, CASP3, MAPK3
25	Alzheimer's disease³⁰ Show member pathways Alzheimers Disease³⁷	8.9	SNCA, MAPK1, MAPT, CASP3, MAPK3
26	Integrated Pancreatic Cancer Pathway³⁷	8.8	CASP3, MAPK3, MAPT, MAPK1, MYC
27	EGFR1 Signaling Pathway³⁷	8.8	HRAS, MAPK3, MAPK1, MYC, SNCA
28	MicroRNAs in cancer³⁰	8.8	MAPK1, CASP3, HMOX1, HRAS, MYC
29	Pathways in cancer³⁰	8.8	MYC, MAPK1, CASP3, HRAS, MAPK3
30	Endometrial cancer³⁰ Show member pathways Colorectal cancer³⁰ Signal transduction PTEN pathway⁵⁹ Acute myeloid leukemia³⁰	8.8	HRAS, MAPK3, CASP3, MYC, MAPK1
31	Sorafenib Pharmacodynamics⁵⁰ Show member pathways VEGF Pathway⁶⁰ Vemurafenib Pathway, Pharmacodynamics⁵⁰	8.8	MYC, CASP3, MAPK3, MAPK1, HRAS
32	NGF Pathway⁵² Show member pathways TRKA Signaling⁵²	8.8	HRAS, CASP3, MAPK3, MAPK1, MYC
33	Development HGF signaling pathway⁵⁹ Show member pathways Development EGFR signaling via PIP3⁵⁹ Development PDGF signaling via MAPK cascades⁵⁹ Apoptosis and survival Anti apoptotic action of membrane bound ESR1⁵⁹ Signaling of Hepatocyte Growth Factor Receptor³⁷ Neurotrophin signaling pathway³⁰ Development EGFR signaling via small GTPases⁵⁹ Development Neurotrophin family signaling⁵⁹ Apoptosis and survival NGF signaling pathway⁵⁹ Apoptosis and survival Role of CDK5 in neuronal death and survival⁵⁹	8.8	MAPK1, MAPK3, CASP3, HRAS, MYC
34	Prostate cancer³⁰ Show member pathways Prostate Cancer³⁷ Integrated Cancer pathway³⁷ Steroid Biosynthesis³⁷	8.8	MAPK1, CASP3, HRAS, MYC, MAPK3
35	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	8.8	MAPK1, MAPK3, CASP3, HRAS, MYC
36	Prolactin signaling pathway³⁰ Show member pathways Prolactin Signaling Pathway³⁷ Development Prolactin receptor signaling⁵⁹ Leptin signaling pathway³⁷	8.8	HRAS, CASP3, MAPK3, MAPK1, MYC
37	Axon guidance³⁰	8.7	CFL1, MAPK1, MAPK3, HRAS
38	CDC42 signaling events³⁷ Show member pathways RAC1 signaling pathway³⁷	8.7	MAPK1, MAPK3, HRAS, CFL1
39	PI3K-Akt signaling pathway³⁰	8.6	HRAS, MYC, MAPK1, MAPK3, CSF3
40	Nanog in Mammalian ESC Pluripotency⁵² Show member pathways GSK3 Signaling⁵² eNOS Signaling⁵² 14-3-3 Induced Intracellular Signaling⁵²	8.6	MAPK1, CASP3, MAPT, MAPK3, SNCA, HRAS
41	Pertussis³⁰	8.6	CASP3, MAPK3, CFL1, MAPK1
42	fMLP Pathway⁵² Show member pathways CXCR4 Pathway⁵² Alpha-Adrenergic Signaling⁵² Huntington's Disease Pathway⁵² CCR3 Pathway in Eosinophils⁵² VEGF and S-1P Signaling⁵² Internalin Pathway⁵² Signal transduction Activation of PKC via G Protein coupled receptor⁵⁹	8.3	CASP3, MAPK3, CFL1, MAPK1, HRAS
43	Proteoglycans in cancer³⁰	8.3	CASP3, HRAS, MYC, HSPB2, MAPK3, MAPK1
44	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	8.3	MYC, MAPK1, MAPK3, CSF3, CASP3, HRAS
45	BDNF signaling pathway³⁷	8.1	MAPK3, MAPT, CASP3, HRAS, MAPK1, CFL1
46	MAPK signaling pathway³⁰ Show member pathways MAPK signaling pathway³⁷	8.1	HSPB2, MAPK1, MAPT, MAPK3, CASP3, HRAS
47	Integrin Pathway⁵² Show member pathways Inhibition of Angiogenesis by TSP1⁵² Transendothelial Migration of Leukocytes⁵² FAK1 Signaling⁵² GnRH Signaling⁵² UPA-UPAR Pathway⁵²	8.0	MAPK3, MAPK1, MYC, CFL1, CASP3, HRAS
48	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	7.8	CFL1, MAPK1, MAPK3, CSF3, HRAS, CASP3
49	Apoptotic Pathways in Synovial Fibroblasts⁵² Show member pathways Actin-Based Motility by Rho Family GTPases⁵² PPAR Pathway⁵² Cellular Apoptosis Pathway⁵² Rac1 Pathway⁵² Glioma Invasiveness⁵² eIF2 Pathway⁵² ERK5 Signaling⁵² p53 Mediated Apoptosis⁵² Mitochondrial Apoptosis⁵² Rap1 Pathway⁵² Telomerase Components in Cell Signaling⁵² Nuclear Receptor Activation by Vitamin-A⁵² DHA Signaling⁵²	7.8	CFL1, MAPK3, MYC, MAPK1, CASP3, MAPT
50	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	7.4	MAPK1, MAPK3, CSF3, CASP3, CFL1, MYC

Compounds for genes affiliated with Corticobasal Degeneration

Sources:
⁴⁴Novoseek, ⁶⁰Tocris Bioscience, ¹²DrugBank, ²⁹IUPHAR, ⁵⁰PharmGKB, ²⁵HMDB, ³BitterDB
See all sources

Compounds related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50) (show all 163)

id	Compound	Score	Top Affiliating Genes
1	thioflavine s⁴⁴	10.1	MAPT, RPS27A, SNCA
2	formate⁴⁴	9.4	RPS27A, SNCA, MAPT, PRDX5
3	radicicol⁴⁴ ⁶⁰ ¹²	11.4	HSPB2, RPS27A, MAPK1, MAPK3
4	6-hydroxydopamine⁴⁴	9.3	SNCA, CASP3, MYC, HMOX1, RPS27A
5	rotenone⁴⁴	9.3	RPS27A, MAPK1, CASP3, HMOX1, SNCA
6	roscovitine⁴⁴	9.2	MAPT, CASP3, MYC, MAPK1, MAPK3
7	nmda⁴⁴ ²⁹	10.2	MAPK3, MAPK1, RPS27A, HRAS, HCRT, MAPT
8	herbimycin a⁴⁴ ⁶⁰	10.2	RPS27A, HRAS, MAPK3, MYC, MAPK1
9	sp 600125⁴⁴ ⁶⁰	10.2	SNCA, CASP3, MAPK3, HMOX1, MAPK1
10	sulforaphane⁴⁴	9.1	PRDX5, MAPK1, CASP3, HMOX1
11	acetylcholine⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.0	HCRT, HSPB2, SNCA, RPS27A, MAPT, HMOX1
12	valine⁴⁴	9.0	SNCA, RPS27A, MAPT, CSF3, HRAS
13	butyrate⁴⁴	9.0	CASP3, MAPK3, MAPT, MAPK1, MYC, RPS27A
14	actinomycin d⁴⁴	8.9	MYC, RPS27A, MAPT, CASP3, HMOX1, MAPK1
15	quercetin⁴⁴ ⁶⁰ ²⁵ ¹²	11.8	HSPB2, MAPK1, MAPK3, CASP3, HMOX1
16	resveratrol⁴⁴ ⁶⁰ ²⁵ ¹²	11.8	CASP3, MAPK3, MAPK1, PRDX5, HMOX1
17	imatinib⁴⁴ ⁵⁰ ¹²	10.8	MYC, RPS27A, MAPK1, CSF3, CASP3
18	ly294002⁴⁴	8.8	HRAS, CASP3, MAPK3, MAPK1, MYC, HMOX1
19	thapsigargin⁴⁴ ⁶⁰	9.8	HCRT, CASP3, MAPK3, MAPK1, HSPB2
20	lactacystin⁴⁴	8.8	MAPK1, SNCA, HMOX1, RPS27A, CASP3, MAPT
21	mg 132⁴⁴ ⁶⁰	9.8	RPS27A, SNCA, MYC, MAPK1, HMOX1, CASP3
22	genistein⁴⁴ ²⁹ ⁶⁰ ³ ²⁵ ¹²	13.7	MYC, HRAS, CASP3, MAPK3, MAPT, MAPK1
23	melphalan⁴⁴ ⁵⁰ ¹²	10.7	PRDX5, MAPK3, MYC, CSF3
24	sb 203580⁴⁴ ⁶⁰	9.6	HSPB2, SNCA, HMOX1, CASP3, MAPK3, MAPK1
25	rapamycin⁴⁴	8.6	HRAS, CASP3, RPS27A, SNCA, MAPK3, MAPK1
26	pd 98,059⁴⁴	8.5	HRAS, MAPK1, CASP3, MYC, HSPB2, MAPK3
27	dopamine⁴⁴ ²⁹ ²⁵ ¹²	11.5	PITX3, HCRT, SNCA, RPS27A, MAPK3, MAPT
28	paclitaxel⁴⁴ ⁵⁰ ¹²	10.5	CASP3, HRAS, CSF3, MAPK3, MAPT, MAPK1
29	arsenite⁴⁴ ²⁵	9.4	HMOX1, CASP3, MAPK3, MAPK1, MYC, HSPB2
30	pge2⁴⁴	8.4	HRAS, HMOX1, MAPK3, MAPK1, RPS27A, SNCA
31	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	11.4	HCRT, MYC, RPS27A, MAPK1, MAPK3, CSF3
32	curcumin⁴⁴	8.3	MYC, HMOX1, MAPK3, CASP3, MAPK1, RPS27A
33	glutamine⁴⁴	8.3	HRAS, MAPT, HSPB2, PRDX5, RPS27A, SNCA
34	arginine⁴⁴	8.2	SNCA, RPS27A, MAPK3, HMOX1, HRAS, HSPB2
35	cycloheximide⁴⁴	8.2	MAPT, MAPK1, RPS27A, MYC, CSF3, CASP3
36	nitric oxide⁴⁴ ²⁵ ¹²	10.2	MAPK3, HRAS, MAPK1, SNCA, HCRT, PRDX5
37	doxorubicin⁴⁴ ⁵⁰ ¹²	10.2	HSPB2, MYC, HRAS, HMOX1, CASP3, MAPT
38	4-hydroxynonenal⁴⁴ ²⁵	9.1	MAPK1, SNCA, MYC, PRDX5, RPS27A, HMOX1
39	cyclosporin a⁴⁴ ²⁹ ⁶⁰	10.1	MYC, PRDX5, RPS27A, MAPT, HRAS, HMOX1
40	cysteine⁴⁴	8.0	GBA, MAPT, PRDX5, SNCA, HRAS, RPS27A
41	estrogen⁴⁴	8.0	HRAS, MAPK3, MYC, PRDX5, RPS27A, MAPK1
42	n acetylcysteine⁴⁴	7.8	HMOX1, CASP3, MAPK3, MAPK1, RPS27A, SNCA
43	oxygen⁴⁴ ²⁵	8.8	SNCA, PRDX5, GBA, HSPB2, HMOX1, HRAS
44	vegf⁴⁴	7.6	MAPK1, MAPK3, CSF3, CASP3, HMOX1, RPS27A
45	h2o2⁴⁴	7.4	RPS27A, MAPK1, MAPK3, HMOX1, HRAS, SNCA
46	retinoic acid⁴⁴ ²⁵	8.3	MAPK3, CASP3, HMOX1, MYC, PRDX5, RPS27A
47	tyrosine⁴⁴	7.3	CSF3, MAPK3, HRAS, MAPK1, RPS27A, SNCA
48	superoxide⁴⁴ ²⁵	8.2	HMOX1, HSPB2, HRAS, TARDBP, CASP3, CSF3
49	serine⁴⁴	7.1	MAPK3, CASP3, MAPT, HRAS, MAPK1, RPS27A
50	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	10.0	HSPB2, MYC, CSF3, HMOX1, PRDX5, CASP3

GO Terms for genes affiliated with Corticobasal Degeneration

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Corticobasal Degeneration according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	pseudopodium	GO:031143	9.8	MAPK3, MAPK1
2	caveola	GO:005901	9.2	HMOX1, MAPK3, MAPK1
3	cytosol	GO:005829	6.7	HRAS, HSPB2, PGAM1, PRDX5, SNCA, RPS27A
4	nucleus	GO:005634	5.4	PRDX5, MYC, HSPB2, CFL1, PITX3, SNCA

Biological processes related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show all 46)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of early endosome to late endosome transport	GO:2000641	10.2	MAPK1, MAPK3
2	regulation of Golgi inheritance	GO:090170	10.2	MAPK1, MAPK3
3	response to epidermal growth factor	GO:070849	10.2	MAPK3, MAPK1
4	caveolin-mediated endocytosis	GO:072584	10.2	MAPK3, MAPK1
5	regulation of stress-activated MAPK cascade	GO:032872	10.1	MAPK3, MAPK1
6	regulation of long-term neuronal synaptic plasticity	GO:048169	10.0	HRAS, SNCA
7	response to estrogen	GO:043627	9.9	GBA, MAPK1, HMOX1
8	stress-activated MAPK cascade	GO:051403	9.9	MAPK3, MAPK1, RPS27A
9	regulation of cytoskeleton organization	GO:051493	9.9	MAPK3, MAPK1
10	toll-like receptor 10 signaling pathway	GO:034166	9.9	RPS27A, MAPK1, MAPK3
11	toll-like receptor 5 signaling pathway	GO:034146	9.9	RPS27A, MAPK1, MAPK3
12	positive regulation of actin cytoskeleton reorganization	GO:2000251	9.9	HRAS, CSF3
13	toll-like receptor TLR6:TLR2 signaling pathway	GO:038124	9.9	RPS27A, MAPK1, MAPK3
14	toll-like receptor TLR1:TLR2 signaling pathway	GO:038123	9.9	RPS27A, MAPK1, MAPK3
15	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.9	HMOX1, MAPK3, MAPK1
16	activation of MAPKK activity	GO:000186	9.9	HRAS, MAPK3, MAPK1
17	toll-like receptor 9 signaling pathway	GO:034162	9.9	RPS27A, MAPK1, MAPK3
18	toll-like receptor 2 signaling pathway	GO:034134	9.9	MAPK3, MAPK1, RPS27A
19	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.9	MAPK3, MAPK1, RPS27A
20	MyD88-independent toll-like receptor signaling pathway	GO:002756	9.9	RPS27A, MAPK1, MAPK3
21	MyD88-dependent toll-like receptor signaling pathway	GO:002755	9.9	RPS27A, MAPK1, MAPK3
22	toll-like receptor 3 signaling pathway	GO:034138	9.9	MAPK3, MAPK1, RPS27A
23	Ras protein signal transduction	GO:007265	9.9	MAPK1, MAPK3, HRAS
24	activation of MAPK activity	GO:000187	9.8	RPS27A, MAPK1, MAPK3
25	toll-like receptor 4 signaling pathway	GO:034142	9.8	RPS27A, MAPK1, MAPK3
26	negative regulation of neuron apoptotic process	GO:043524	9.8	HRAS, HMOX1, SNCA
27	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	9.8	MAPK3, MAPK1
28	toll-like receptor signaling pathway	GO:002224	9.8	RPS27A, MAPK1, MAPK3
29	fibroblast growth factor receptor signaling pathway	GO:008543	9.7	RPS27A, MAPK1, MAPK3, HRAS
30	Fc-epsilon receptor signaling pathway	GO:038095	9.7	RPS27A, MAPK1, MAPK3, HRAS
31	epidermal growth factor receptor signaling pathway	GO:007173	9.7	HRAS, MAPK3, MAPK1, RPS27A
32	regulation of excitatory postsynaptic membrane potential	GO:060079	9.6	SNCA, HCRT
33	insulin receptor signaling pathway	GO:008286	9.6	HRAS, MAPK3, MAPK1
34	MAPK cascade	GO:000165	9.6	HRAS, MAPK3, MAPK1, MYC
35	small GTPase mediated signal transduction	GO:007264	9.5	HRAS, HMOX1, MAPK3, MAPK1
36	organ morphogenesis	GO:009887	9.5	HRAS, MAPK3, MAPK1, PITX3
37	apoptotic process	GO:006915	9.3	RPS27A, MAPK1, MAPT, MAPK3, CASP3
38	neurotrophin TRK receptor signaling pathway	GO:048011	9.3	RPS27A, MAPK1, MAPK3, CASP3, HRAS
39	Fc-gamma receptor signaling pathway involved in phagocytosis	GO:038096	9.3	MAPK3, MAPK1, CFL1
40	cellular response to DNA damage stimulus	GO:006974	9.2	CASP3, MAPK1, MYC
41	positive regulation of cell proliferation	GO:008284	9.1	MYC, MAPK1, CSF3, HRAS
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.1	MYC, RPS27A, MAPK3, CSF3, HRAS
43	axon guidance	GO:007411	8.9	HRAS, MAPK3, MAPK1, CFL1
44	innate immune response	GO:045087	8.8	CFL1, RPS27A, MAPK1, MAPK3, HRAS
45	blood coagulation	GO:007596	8.7	CFL1, MAPK1, MAPK3, HRAS
46	negative regulation of apoptotic process	GO:043066	8.2	CFL1, MYC, PRDX5, SNCA, RPS27A, CASP3

Molecular functions related to Corticobasal Degeneration according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MAP kinase activity	GO:004707	9.7	MAPK1, MAPK3
2	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO:043027	9.5	SNCA, PRDX5
3	phosphotyrosine binding	GO:001784	9.5	MAPK3, MAPK1
4	protein binding	GO:005515	6.2	HRAS, GBA, CFL1, HSPB2, PGAM1, MYC