CBGD
MCID: CRT033
MIFTS: 53

Corticobasal Degeneration (CBGD) malady

Neuronal category

Summaries for Corticobasal Degeneration

Sources:
43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NINDS:44 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to progressive supranuclear palsy and frontotemporal dementia. An important gene associated with Corticobasal Degeneration is MAPT (microtubule-associated protein tau), and among its related pathways are Nongenotropic Androgen signaling and SHC1 events in ERBB2 signaling. The compounds cycloheximide and butyrate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are taste/olfaction and renal/urinary system.

NIH Rare Diseases:43 Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/4/2010

Wikipedia:64 Corticobasal degeneration (CBD) or Corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

Aliases & Classifications for Corticobasal Degeneration

Sources:
43NIH Rare Diseases, 44NINDS, 49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
corticobasal degeneration:
Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

corticobasal degeneration 43 44 49 61
cortical-basal ganglionic degeneration 43
cortico-basal ganglionic degeneration 43
cbgd 43


External Ids:

ICD10 via Orphanet26 G31.0
SNOMED-CT via Orphanet58 18842008
UMLS via Orphanet62 C0393570

Related Diseases for Corticobasal Degeneration

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1progressive supranuclear palsy31.6RPS27A, SNCA, HCRT, MAPT
2frontotemporal dementia31.0TARDBP, SNCA, MAPT, RPS27A
3aphasia31.0MAPT, TARDBP
4pick's disease30.9RPS27A, SNCA, MAPT, TARDBP
5alzheimer's disease30.9MAPK1, HCRT, TARDBP, HRAS, HMOX1, MAPK3
6parkinson's disease30.8MAPK3, SNCA, RPS27A, CASP3, GBA, MAPT
7primary progressive aphasia30.8RPS27A, MAPT
8tauopathy30.7MAPT, RPS27A, SNCA
9brain disease30.6HCRT, MAPT, SNCA
10semantic dementia30.5MAPT, RPS27A
11lateral sclerosis30.3MAPT, SNCA
12amyotrophic lateral sclerosis30.3TARDBP, MAPT, SNCA, CASP3, HSPB2, RPS27A
13lewy body dementia30.1RPS27A, SNCA, MAPT
14creutzfeldt-jakob syndrome30.1RPS27A, SNCA, MAPT
15striatonigral degeneration30.1SNCA, RPS27A
16apraxia10.8
17myoclonus10.6
18hemiparkinsonism-hemiatrophy syndrome10.3
19n syndrome10.3
20basal ganglia disease10.3
21sleep disorder10.3
22progressive supranuclear palsy atypical10.3
23cerebellar degeneration10.3
24corticobasal degeneration, mapt-related10.3
25fahr's syndrome10.3
26progressive supranuclear palsy - corticobasal syndrome10.3
27antiphospholipid syndrome10.1
28olivopontocerebellar atrophy10.1
29ideomotor apraxia10.1
30hereditary diffuse leukoencephalopathy with spheroids10.1
31supranuclear ocular palsy10.1
32neurosyphilis10.1
33pointer syndrome10.1
34ataxia10.1
35dementia - subcortical10.1
36parkinson disease 110.1
37memory impairment10.1
38parkinson disease 1210.1
39posterior cortical atrophy10.1
40argyrophilic grain disease10.1
41multiple sclerosis10.0HCRT
42endometriosis10.0RPS27A
43neuronal intranuclear inclusion disease10.0RPS27A
44pancreatitis10.0HRAS
45bladder carcinoma10.0HRAS
46cerebral amyloid angiopathy10.0MAPT
47tuberculosis10.0PRDX5
48hepatitis b10.0HRAS
49cystic fibrosis10.0HMOX1
50neuroblastoma10.0MYC

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to corticobasal degeneration

Clinical Features for Corticobasal Degeneration

Drugs & Therapeutics for Corticobasal Degeneration

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Corticobasal Degeneration

Drug clinical trials:

Search ClinicalTrials for Corticobasal Degeneration

Search NIH Clinical Center for Corticobasal Degeneration

Search CenterWatch for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

Anatomical Context for Corticobasal Degeneration

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Corticobasal Degeneration:

33
Brain, Cortex, Spinal cord, Parietal lobe, Temporal lobe, Thalamus

Animal Models for Corticobasal Degeneration or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Corticobasal Degeneration

Sources:
51PubMed
See all sources

Articles related to Corticobasal Degeneration:

(show top 50)    (show all 372)
idTitleAuthorsYear
1
Analysis of PITX3 gene in patients with multisystem atrophy, progressive supranuclear palsy and corticobasal degeneration. (23694789)
2013
2
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration. (23121727)
2013
3
Dystonia in corticobasal degeneration: a review of the literature on 404 pathologically proven cases. (22550031)
2012
4
Novel FUS mutation in patients with sporadic amyotrophic lateral sclerosis and corticobasal degeneration. (22999566)
2012
5
Cortical origin of myoclonus in early stages of corticobasal degeneration. (21484866)
2011
6
Sensory alien hand syndrome in corticobasal degeneration: a cerebral blood flow study. (20589869)
2010
7
Universal grammar in the frontotemporal dementia spectrum: evidence of a selective disorder in the corticobasal degeneration syndrome. (17640688)
2007
8
Asymmetrical alien hands in corticobasal degeneration. (17230447)
2007
9
Corticobasal degeneration and progressive aphasia. (17060571)
2006
10
CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration. (17005202)
2006
11
Clinical and neuropsychological features of corticobasal degeneration. (16310834)
2006
12
MRI correlates of alien leg-like phenomenon in corticobasal degeneration. (15799014)
2005
13
Proton magnetic resonance neurospectroscopy and EEG cartography in corticobasal degeneration: correlations with neuropsychological signs. (15314134)
2004
14
Functional imaging as a window to dementia: corticobasal degeneration. (15616165)
2004
15
Coherence analysis in the myoclonus of corticobasal degeneration. (14639679)
2003
16
Corticobasal degeneration: structural and functional MRI and single-photon emission computed tomography. (13680027)
2003
17
Corticobasal degeneration as a cognitive disorder. (14639661)
2003
18
Procerus sign in corticobasal degeneration. (12521221)
2002
19
Masked myoclonus in corticobasal degeneration: neurophysiological study of a case. (11851011)
2002
20
Cerebellar cortical tau pathology in progressive supranuclear palsy and corticobasal degeneration. (11935262)
2002
21
Neural and cognitive bases of upper limb apraxia in corticobasal degeneration. (11591846)
2001
22
Cerebral blood flow SPECT may be helpful in establishing the diagnosis of progressive supranuclear palsy and corticobasal degeneration. (14600888)
2001
23
Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype. (11425937)
2001
24
Substantia nigra in progressive supranuclear palsy, corticobasal degeneration, and parkinsonism-dementia complex of Guam: specific pathological features. (11305875)
2001
25
Corticobasal degeneration. (11346025)
2001
26
Phenotypes and prognosis: clinicopathologic studies of corticobasal degeneration. (10624482)
2000
27
Aphasia in corticobasal degeneration. (10624476)
2000
28
Immunohistochemistry distinguishes: between Pick's disease and corticobasal degeneration. (11185644)
2000
29
Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease. (10965796)
2000
30
Myoclonus in corticobasal degeneration and other neurodegenerations. (10624472)
2000
31
Functional imaging studies in corticobasal degeneration. (10624484)
2000
32
Parkinsonism in corticobasal degeneration. (10624473)
2000
33
Longitudinal ocular motor study in corticobasal degeneration and progressive supranuclear palsy. (10720270)
2000
34
A comparison of tau protein in cerebrospinal fluid between corticobasal degeneration and progressive supranuclear palsy. (10025574)
1999
35
Dyspraxia in a patient with corticobasal degeneration: the role of visual and tactile inputs to action. (10449556)
1999
36
Cerebral blood flow correlates of higher brain dysfunctions in corticobasal degeneration. (10616866)
1999
37
Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration. (10653307)
1999
38
Pathologic heterogeneity in clinically diagnosed corticobasal degeneration. (10489043)
1999
39
Heterogeneity of glucose metabolism in corticobasal degeneration. (9879684)
1998
40
Neuropsychological and neuroimaging correlates in corticobasal degeneration. (10933454)
1998
41
Familial dementia lacking specific pathological features presenting with clinical features of corticobasal degeneration. (9771798)
1998
42
Accuracy of the clinical diagnosis of corticobasal degeneration: a clinicopathologic study. (9008506)
1997
43
A clinical profile of corticobasal degeneration presenting as primary progressive aphasia. (8738941)
1996
44
Pick complex and Pick's disease: the nosology of frontal lobe dementia, primary progressive aphasia, and corticobasal ganglionic degeneration. (21284785)
1996
45
Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease. (8928611)
1996
46
The neuropsychological pattern of corticobasal degeneration: comparison with progressive supranuclear palsy and Alzheimer's disease. (7644044)
1995
47
Unusual case of corticobasal degeneration with tau/Gallyas-positive neuronal and glial tangles. (7879609)
1994
48
The nature of apraxia in corticobasal degeneration. (7798996)
1994
49
The nature of apraxia in corticobasal degeneration. (8163995)
1994
50
Abnormal cytoskeletal pathology peculiar to corticobasal degeneration is different from that of Alzheimer's disease or progressive supranuclear palsy. (7839832)
1994

Genetic Variations for Corticobasal Degeneration

Expression for genes affiliated with Corticobasal Degeneration

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for genes affiliated with Corticobasal Degeneration

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN, 30KEGG, 50PharmGKB, 60Tocris Bioscience
See all sources

Pathways related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MAPK1, HRAS, MAPK3
2
Hide members
9.5MAPK1, HRAS, MAPK3
3
Hide members
9.5MAPK3, HRAS, MAPK1
4
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.5HRAS, MAPK3, MAPK1
5
Immune response IL-6 signaling pathway
Hide members
9.5MAPK3, MAPK1, HRAS
69.5MAPK3, MAPK1, HRAS
79.5MAPK1, MAPK3, SNCA
8
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
Hide members
9.4MYC, MAPK1, MAPK3
9
Hide members
9.3MAPK3, RPS27A, HRAS, MAPK1
10
Hide members
9.3RPS27A, HRAS, MAPK1, MAPK3
11
Development A3 receptor signaling
Hide members
9.2MYC, MAPK1, MAPK3, HRAS
12
Immune response IL-2 activation and signaling pathway
Hide members
9.2MYC, MAPK1, MAPK3, HRAS
13
Hide members
9.2HRAS, MYC, MAPK3, MAPK1
14
Hide members
9.2MYC, MAPK1, HRAS, MAPK3
159.2HRAS, MYC, MAPK1, MAPK3
16
Development PDGF signaling via STATs and NF-kB
Hide members
9.2MYC, MAPK3, MAPK1, HRAS
17
Hide members
9.2HRAS, MAPK1, MYC, MAPK3
189.2MAPK3, MAPK1, MYC, HRAS
199.2MAPK3, MAPK1, MYC, HRAS
20
Development EPO-induced Jak-STAT pathway
Hide members
9.2MAPK1, MAPK3, HRAS, MYC
219.2MAPK1, CASP3, MAPK3, HRAS
22
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.2HRAS, MAPK1, MAPK3, CASP3
23
Hide members
9.2HRAS, MAPK1, MAPK3, CASP3
24
Hide members
9.2CASP3, MAPK3, MAPK1, HRAS
259.1MAPK3, MYC, CASP3, MAPK1
26
Hide members
9.0HRAS, MAPT, MYC, MAPK1, MAPK3
279.0MAPK1, MAPK3, CFL1
289.0MAPK3, MAPK1, MAPT, CASP3, HRAS
298.9HRAS, MAPK1, SNCA, MAPK3, MYC
308.9CASP3, MAPK3, MAPT, MYC, MAPK1
318.8HRAS, MYC, MAPK1, MAPK3, CASP3
32
Development Prolactin receptor signaling
Hide members
8.8MAPK1, CASP3, HRAS, MYC, MAPK3
33
Hide members
8.8MYC, CASP3, MAPK3, MAPK1, HRAS
34
Hide members
8.8CASP3, MAPK1, MYC, HRAS, MAPK3
35
Hide members
8.8HRAS, MYC, MAPK3, CASP3, MAPK1
36
Hide members
8.8MAPK3, MAPK1, MYC, HRAS, CASP3
37
Hide members
8.8CASP3, MYC, MAPK1, HRAS, MAPK3
38
Hide members
8.8MAPK1, CASP3, MYC, HRAS, MAPK3
398.8MAPK1, MYC, HRAS, HMOX1, CASP3
40
Hide members
8.7CFL1, HRAS, MAPK1, MAPK3
418.7HRAS, MAPK1, CFL1, MAPK3
42
Hide members
8.6MAPK1, HRAS, CASP3, MAPK3, SNCA, MAPT
438.6CFL1, MAPK1, MAPK3, CASP3
44
Hide members
8.3MAPK1, HRAS, CASP3, MAPK3, CFL1
458.3MYC, HSPB2, CASP3, MAPK3, MAPK1, HRAS
468.1CASP3, MAPT, MAPK1, HRAS, CFL1, MAPK3
47
Hide members
8.1MAPK3, HRAS, MYC, HSPB2, CASP3, MAPK1
48
Hide members
8.0MAPK1, CASP3, MYC, MAPK3, CFL1, HRAS
49
Hide members
7.8CFL1, MAPK3, CSF3, MAPK1, CASP3, HRAS
50
Hide members
7.8CASP3, MAPK1, MAPK3, MYC, HRAS, CFL1

Compounds for genes affiliated with Corticobasal Degeneration

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7MAPT
2butyrate4510.4RPS27A, MAPT
3thioflavine s4510.1RPS27A, SNCA, MAPT
4rotenone4510.0SNCA, HMOX1, RPS27A
5pge2459.9HRAS, SNCA
6thapsigargin45 6010.8MAPK3, CASP3, HCRT
7nmda45 2910.6RPS27A, MAPK3, MAPT, HCRT, HRAS
8resveratrol45 60 11 2412.6MAPK3, HMOX1, PRDX5
9formate459.5SNCA, RPS27A, MAPT, PRDX5
10radicicol45 60 1111.4HSPB2, MAPK3, RPS27A, MAPK1
11c2ceramide459.4MAPK3, MAPT, MAPK1, CASP3
126-hydroxydopamine459.3SNCA, MYC, CASP3, RPS27A, HMOX1
13dexamethasone45 50 29 1112.3MYC, MAPK1, MAPK3, HCRT
14roscovitine459.3MAPT, MAPK1, CASP3, MYC, MAPK3
15herbimycin a45 6010.3MAPK1, HRAS, MYC, MAPK3, RPS27A
16rottlerin459.2MAPK1, HMOX1, MAPK3, CASP3
17ly294002459.2MAPK3, MYC, HMOX1, MAPK1, HRAS
18sp 60012545 6010.2CASP3, SNCA, MAPK3, HMOX1, MAPK1
19valine459.2SNCA, RPS27A, MAPT, HRAS, CSF3
20serine459.1MAPT, HRAS, SNCA, GBA, HSPB2
21sulforaphane459.1HMOX1, PRDX5, CASP3, MAPK1
22acetylcholine45 50 29 11 2413.0HCRT, MAPT, HMOX1, SNCA, HSPB2, RPS27A
2315-deoxy-delta-12,14-prostaglandin j2458.9CASP3, MAPK1, HMOX1, MYC
24quercetin45 60 11 2411.9HSPB2, CASP3, MAPK3, HMOX1, MAPK1
25melphalan45 119.9MAPK3, PRDX5, MYC, CSF3
26actinomycin d458.9MAPK1, HMOX1, MYC, CASP3, RPS27A, MAPT
27imatinib45 50 1110.9MYC, MAPK1, CSF3, CASP3, RPS27A
28genistein45 29 60 2 11 2413.8CASP3, MAPK3, MAPK1, HRAS, MYC, MAPT
29lactacystin458.7RPS27A, CASP3, MAPK1, SNCA, MAPT, MYC
30mg 13245 609.7RPS27A, CASP3, MAPT, MAPK1, MYC, HMOX1
31paclitaxel45 50 1110.7MAPK1, CASP3, MAPK3, MYC, HRAS, CSF3
32daunorubicin45 50 1110.7MAPK3, CSF3, CASP3, MYC
33rapamycin458.6SNCA, HRAS, MYC, MAPK1, CASP3, RPS27A
34sb 20358045 609.6HMOX1, SNCA, MAPK1, MAPK3, CASP3, HSPB2
35pd 98,059458.6MAPK3, CASP3, HSPB2, MAPK1, HRAS, MYC
36arsenite45 249.4HMOX1, MYC, MAPK3, CASP3, HSPB2, RPS27A
37curcumin458.3PRDX5, MYC, MAPK1, MAPK3, CASP3, RPS27A
38glutamine458.3RPS27A, HSPB2, SNCA, PRDX5, MAPT, HRAS
39oxygen45 249.3HSPB2, HMOX1, HRAS, GBA, PRDX5, SNCA
40doxorubicin45 50 1110.1RPS27A, CSF3, MAPT, MYC, HRAS, HMOX1
414-hydroxynonenal45 249.1MAPT, RPS27A, MYC, MAPK1, PRDX5, SNCA
42cyclosporin a45 29 6010.0RPS27A, MYC, HRAS, CASP3, CSF3, PRDX5
43nitric oxide45 11 2410.0SNCA, HRAS, GBA, MAPK1, MAPK3, PRDX5
44n acetylcysteine457.8MAPT, PRDX5, HMOX1, MAPK3, SNCA, CASP3
45cysteine457.8HMOX1, GBA, MAPT, RPS27A, MAPK3, PRDX5
46vegf457.6HSPB2, HRAS, MYC, MAPK1, CSF3, MAPK3
47superoxide45 248.5HSPB2, CSF3, PRDX5, TARDBP, CASP3, CFL1
48h2o2457.4HRAS, MAPT, MAPK3, RPS27A, HSPB2, SNCA
49retinoic acid45 248.3HMOX1, MAPK3, RPS27A, CSF3, PRDX5, MAPT
50cisplatin45 50 60 1110.0HSPB2, RPS27A, PRDX5, MAPK3, MAPK1, HMOX1

GO Terms for genes affiliated with Corticobasal Degeneration

Sources:
16Gene Ontology
See all sources

Cellular components related to Corticobasal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pseudopodiumGO:0311439.8MAPK1, MAPK3
2caveolaGO:0059019.4HMOX1, MAPK1, MAPK3
3cytosolGO:0058296.7PGAM1, HRAS, HMOX1, MAPT, MAPK3, PRDX5
4nucleusGO:0056345.7CFL1, HMOX1, HRAS, TARDBP, MYC, MAPK1

Biological processes related to Corticobasal Degeneration according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1regulation of early endosome to late endosome transportGO:200064110.2MAPK3, MAPK1
2regulation of Golgi inheritanceGO:09017010.2MAPK1, MAPK3
3response to epidermal growth factor stimulusGO:07084910.2MAPK1, MAPK3
4caveolin-mediated endocytosisGO:07258410.2MAPK3, MAPK1
5regulation of stress-activated MAPK cascadeGO:03287210.1MAPK1, MAPK3
6positive regulation of actin cytoskeleton reorganizationGO:200025110.0CSF3, HRAS
7activation of MAPKK activityGO:0001869.9MAPK1, HRAS, MAPK3
8stress-activated MAPK cascadeGO:0514039.9MAPK3, MAPK1, RPS27A
9toll-like receptor 10 signaling pathwayGO:0341669.9MAPK1, MAPK3, RPS27A
10toll-like receptor 5 signaling pathwayGO:0341469.9RPS27A, MAPK3, MAPK1
11regulation of sequence-specific DNA binding transcription factor activityGO:0510909.9MAPK3, HMOX1, MAPK1
12toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.9MAPK1, RPS27A, MAPK3
13toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.9MAPK1, RPS27A, MAPK3
14toll-like receptor 9 signaling pathwayGO:0341629.9RPS27A, MAPK1, MAPK3
15toll-like receptor 2 signaling pathwayGO:0341349.9RPS27A, MAPK3, MAPK1
16Ras protein signal transductionGO:0072659.9MAPK1, MAPK3, HRAS
17TRIF-dependent toll-like receptor signaling pathwayGO:0356669.8MAPK1, MAPK3, RPS27A
18MyD88-independent toll-like receptor signaling pathwayGO:0027569.8RPS27A, MAPK1, MAPK3
19MyD88-dependent toll-like receptor signaling pathwayGO:0027559.8MAPK1, MAPK3, RPS27A
20toll-like receptor 3 signaling pathwayGO:0341389.8RPS27A, MAPK3, MAPK1
21regulation of cytoskeleton organizationGO:0514939.8MAPK1, MAPK3
22organ morphogenesisGO:0098879.8MAPK1, HRAS, MAPK3
23activation of MAPK activityGO:0001879.7RPS27A, MAPK1, MAPK3
24fibroblast growth factor receptor signaling pathwayGO:0085439.7MAPK3, HRAS, MAPK1, RPS27A
25toll-like receptor 4 signaling pathwayGO:0341429.7RPS27A, MAPK3, MAPK1
26Fc-epsilon receptor signaling pathwayGO:0380959.7MAPK1, RPS27A, MAPK3, HRAS
27negative regulation of neuron apoptotic processGO:0435249.7HMOX1, SNCA, HRAS
28epidermal growth factor receptor signaling pathwayGO:0071739.7HRAS, RPS27A, MAPK1, MAPK3
29MAPK cascadeGO:0001659.6HRAS, MYC, MAPK1, MAPK3
30response to DNA damage stimulusGO:0069749.5MAPK3, MYC, CASP3, MAPK1
31neurotrophin TRK receptor signaling pathwayGO:0480119.3HRAS, RPS27A, CASP3, MAPK3, MAPK1
32toll-like receptor signaling pathwayGO:0022249.2MAPK1, MAPK3, RPS27A
33Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.2MAPK3, CFL1, MAPK1
34small GTPase mediated signal transductionGO:0072649.1MAPK1, HMOX1, HRAS, MAPK3
35apoptotic processGO:0069159.1RPS27A, MAPK1, CASP3, MAPK3, MAPT
36axon guidanceGO:0074118.7HRAS, CFL1, MAPK3, MAPK1
37innate immune responseGO:0450878.6HRAS, CFL1, MAPK1, MAPK3, RPS27A
38negative regulation of apoptotic processGO:0430668.2RPS27A, CASP3, SNCA, PRDX5, MYC, CFL1

Molecular functions related to Corticobasal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphotyrosine bindingGO:0017849.8MAPK1, MAPK3
2MAP kinase activityGO:0047079.5MAPK1, MAPK3

Products for genes affiliated with Corticobasal Degeneration

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Corticobasal Degeneration

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet