Corticobasal Degeneration disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRT033 MIFTS: 51	Corticobasal Degeneration Categories: Rare diseases, Neuronal diseases
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Aliases & Classifications for Corticobasal Degeneration

MalaCards integrated aliases for Corticobasal Degeneration:

Name: Corticobasal Degeneration ⁴⁹ ⁵⁰ ⁶⁹

Corticobasal Syndrome ⁴⁹ ⁵⁵

Cortical-Basal Ganglionic Degeneration ⁴⁹

Cortico-Basal Ganglionic Degeneration ⁴⁹

Cbgd ⁴⁹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the nervous system

Other degenerative diseases of the nervous system

Other degenerative diseases of nervous system, not elsewhere classified

Circumscribed brain atrophy

Orphanet: ⁵⁵

Rare neurological diseases

External Ids:

Orphanet ⁵⁵ ORPHA454887

ICD10 via Orphanet ³³ G31.0

UMLS ⁶⁹ C0393570

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Summaries for Corticobasal Degeneration

NINDS : ⁵⁰ Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, akinesia (an absence of movements), rigidity (a resistance to imposed movement),disequilibrium (impaired balance); and limb dystonia (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, myoclonus (muscular jerks), and dysphagia (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards based summary : Corticobasal Degeneration, also known as corticobasal syndrome, is related to frontotemporal lobar degeneration with tdp43 inclusions, grn-related and pick disease of brain. An important gene associated with Corticobasal Degeneration is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Pathways in cancer and Neuroscience. The drugs Iodine and cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and tongue, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

NIH Rare Diseases : ⁴⁹ Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known. Treatment depends on the symptoms in each person. People with corticobasal degeneration usually do not survive beyond an average of 7 years after symptoms begin. Aspiration pneumonia or other complications are usually the cause of death. Last updated: 3/13/2017

Wikipedia : ⁷² Corticobasal degeneration (CBD) or corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

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Related Diseases for Corticobasal Degeneration

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Related Disease	Score	Top Affiliating Genes
1	frontotemporal lobar degeneration with tdp43 inclusions, grn-related	32.6	MAPT RPS27A
2	pick disease of brain	32.4	CRYAB MAPT RPS27A TARDBP
3	semantic dementia	32.4	MAPT RPS27A TARDBP
4	leukoencephalopathy, hereditary diffuse, with spheroids	31.9	CRYAB MAPT RPS27A
5	supranuclear palsy, progressive, 1	31.7	LRRK2 MAPT MOBP RPS27A TARDBP
6	frontotemporal dementia	31.4	CRYAB LRRK2 MAPT MOBP RPS27A TARDBP
7	progressive supranuclear palsy-corticobasal syndrome	12.1
8	classic progressive supranuclear palsy syndrome	10.8
9	dementia	10.5
10	alzheimer disease	10.5
11	apraxia	10.5
12	aphasia	10.4
13	cerebritis	10.4
14	myoclonus	10.3
15	neuronitis	10.3
16	multiple system atrophy 1	10.2
17	postencephalitic parkinson disease	10.2	LRRK2 MAPT TARDBP
18	hereditary late-onset parkinson disease	10.2	GBA LRRK2
19	creutzfeldt-jakob disease	10.1
20	parkinson disease 2, autosomal recessive juvenile	10.1	LRRK2 UCHL1
21	colorblindness, partial, deutan series	10.1
22	dystonia	10.1
23	inclusion body myositis	10.1	MAPT RPS27A TARDBP
24	tremor	10.0	GBA LRRK2 MAPT
25	parkinson disease 3, autosomal dominant	10.0	LRRK2 MAPT
26	synucleinopathy	10.0	GBA LRRK2 MAPT RPS27A
27	amyotrophic lateral sclerosis 1	9.9
28	basal ganglia calcification	9.9
29	lateral sclerosis	9.9
30	rem sleep behavior disorder	9.9
31	progressive non-fluent aphasia	9.9
32	central nervous system disease	9.9	CRYAB LRRK2 MAPT TARDBP
33	fibrosis of extraocular muscles, congenital, 1	9.8
34	stiff-person syndrome	9.8
35	hydrocephalus, normal-pressure	9.8
36	ifap syndrome with or without bresheck syndrome	9.8
37	paine syndrome	9.8
38	ataxia and polyneuropathy, adult-onset	9.8
39	aging	9.8
40	apraxia of eyelid opening	9.8
41	episodic pain syndrome, familial, 1	9.8
42	hydrocephalus	9.8
43	pulmonary fibrosis	9.8
44	hyperekplexia 1	9.8
45	arachnoiditis	9.8
46	parametritis	9.8
47	neuroleptic malignant syndrome	9.8
48	olivopontocerebellar atrophy	9.8
49	antiphospholipid syndrome	9.8
50	complex regional pain syndrome	9.8

Graphical network of the top 20 diseases related to Corticobasal Degeneration:

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Symptoms & Phenotypes for Corticobasal Degeneration

GenomeRNAi Phenotypes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability with paclitaxel	GR00179-A-1	9.02	MTOR RPS6KB1
2	Decreased viability with paclitaxel	GR00179-A-2	9.02	MTOR
3	Decreased viability with paclitaxel	GR00179-A-3	9.02	MTOR RPS6KB1

MGI Mouse Phenotypes related to Corticobasal Degeneration:

⁴³ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.27	ROCK1 TARDBP UCHL1 CFL1 CRYAB GBA
2	cellular	MP:0005384	10.27	CFL1 CRYAB GBA HSPB2 LRRK2 MAPT
3	cardiovascular system	MP:0005385	10.26	MTOR PITX3 ROCK1 ROCK2 RPS6KB1 SOS1
4	homeostasis/metabolism	MP:0005376	10.22	CFL1 GBA KIF13B LRRK2 MAPT MTOR
5	hematopoietic system	MP:0005397	10.17	MAPT MTOR PITX3 ROCK1 RPS6KB1 SOS1
6	immune system	MP:0005387	10.11	CSF3 GBA LRRK2 MAPT MTOR PITX3
7	integument	MP:0010771	9.97	PITX3 ROCK1 SOS1 UCHL1 CFL1 CSF3
8	nervous system	MP:0003631	9.93	CFL1 GBA LRRK2 MAPT MOBP MTOR
9	muscle	MP:0005369	9.86	CRYAB MAPT MTOR ROCK1 ROCK2 RPS6KB1
10	no phenotypic analysis	MP:0003012	9.56	CFL1 KIF13B LRRK2 MAPT MTOR PITX3
11	renal/urinary system	MP:0005367	9.17	CFL1 CSF3 LRRK2 MAPT MTOR ROCK1

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Drugs & Therapeutics for Corticobasal Degeneration

Drugs for Corticobasal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Iodine

Approved, Investigational

Phase 4

7553-56-2

807

cadexomer iodine

Phase 4

Pharmaceutical Solutions

Phase 4

Calamus

Nutraceutical

Phase 4

Pimavanserin

Approved, Investigational

Phase 3

706779-91-1

16058810

Coenzyme Q10

Approved, Investigational, Nutraceutical

Phase 2, Phase 3

303-98-0

5281915

Ubiquinone

Phase 2, Phase 3

Central Nervous System Depressants

Phase 3,Phase 1,Phase 2

Micronutrients

Phase 2, Phase 3

Trace Elements

Phase 2, Phase 3

Tranquilizing Agents

Phase 3,Phase 1,Phase 2

Vitamins

Phase 2, Phase 3

Psychotropic Drugs

Phase 3,Phase 1,Phase 2

Serotonin

Phase 3

50-67-9

5202

Serotonin Agents

Phase 3

Neurotransmitter Agents

Phase 3

Antipsychotic Agents

Phase 3

Antiparkinson Agents

Phase 3

Lithium carbonate

Phase 1, Phase 2

554-13-2

Fluorodeoxyglucose F18

Phase 2

Antidepressive Agents

Phase 1, Phase 2

Antimanic Agents

Phase 1, Phase 2

Radiopharmaceuticals

Phase 2

taxane

Phase 1

Levodopa

Approved

59-92-7

6047

Pramipexole

Approved, Investigational

104632-26-0

119570 59868

Entacapone

Approved, Investigational

130929-57-6

5281081

Carbidopa

Approved

28860-95-9

38101 34359

Ropinirole

Approved, Investigational

91374-20-8, 91374-21-9

5095 497540

Amantadine

Approved

768-94-5

2130

Vaccines

Interventional clinical trials:

(show all 36)

#	Name	Status	NCT ID	Phase	Drugs
1	DaTSCAN Imaging in Aging and Neurodegenerative Disease	Enrolling by invitation	NCT01453127	Phase 4	I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
2	Effects of Coenzyme Q10 in PSP and CBD	Completed	NCT00532571	Phase 2, Phase 3	CoQ10
3	Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis	Recruiting	NCT03325556	Phase 3	Placebo;Pimavanserin 34 mg;Pimavanserin 20 mg
4	A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration	Completed	NCT00703677	Phase 1, Phase 2	Lithium
5	Electrical Polarization of the Brain in Corticobasal Syndrome	Completed	NCT00273897	Phase 2
6	The Differential Diagnosis of Parkinson's Disease and Parkinsonism by Positron-emission Tomography	Completed	NCT01824056	Phase 2	18F-FDG
7	Davunetide (AL-108) in Predicted Tauopathies - Pilot Study	Active, not recruiting	NCT01056965	Phase 2	davunetide (AL-108, NAP);Placebo nasal spray
8	Novel Neuroimage Study in Tauopathies With Parkinsonism	Active, not recruiting	NCT03386669	Phase 2	F-18
9	Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers	Completed	NCT02167594	Phase 1	18F-AV-1451;florbetapir F18
10	Safety Study of TPI-287 to Treat CBS and PSP	Active, not recruiting	NCT02133846	Phase 1	TPI 287 2 mg/m2;TPI-287 20 mg/m2;Placebo;TPI-287 6.3 mg/m2
11	Innovative Biomarkers in Alzheimer's Disease and Frontotemporal Dementia (FTD): Preventative and Personalized	Unknown status	NCT01403519
12	Repetitive Transcranial Magnetic Stimulation (TMS) for Progressive Supranuclear Palsy and Corticobasal Degeneration	Completed	NCT01174771
13	Study of Tongue Pressures	Completed	NCT00013832
14	PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK	Recruiting	NCT02778607
15	4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2	Recruiting	NCT02966145
16	More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease	Recruiting	NCT03076671
17	Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)	Recruiting	NCT02365922
18	Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders	Recruiting	NCT03299062
19	Parkinson's Disease, Diagnostic Observations (PADDO)	Recruiting	NCT01249768
20	Gait Analysis in Neurological Disease	Recruiting	NCT02994719		Anti-Parkinson medication
21	Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.	Recruiting	NCT02132052
22	ADDIA Proof-of-Performance Clinical Study	Recruiting	NCT03030586
23	Positron Emission Tomography (PET) Imaging of Tau Pathology in Neurodegenerative Disease	Recruiting	NCT03143374
24	Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia	Recruiting	NCT03225144
25	The Swedish BioFINDER 2 Study	Recruiting	NCT03174938
26	Diagnosing Frontotemporal Lobar Degeneration	Recruiting	NCT02964637
27	Autologous Stem/Stromal Cells in Neurological Disorders and Disease	Recruiting	NCT03297177
28	Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks	Recruiting	NCT03153371
29	Genetic Characterization of Movement Disorders and Dementias	Recruiting	NCT02014246
30	Vaccination Uptake (VAX) in PD	Recruiting	NCT02874274
31	Comprehensive Assessment of Neurodegeneration and Dementia	Recruiting	NCT03402919
32	4 Repeat Tauopathy Neuroimaging Initiative	Active, not recruiting	NCT01804452
33	Study for the Early Diagnosis of Parkinson's Disease	Active, not recruiting	NCT02283073
34	The Sunnybrook Dementia Study: Mapping Brain Changes in Alzheimer's, Vascular and Other Dementias	Active, not recruiting	NCT01800214
35	SudoScan as a Biomarker of Parkinson's Disease	Active, not recruiting	NCT02767037
36	Brain Network Activation in Patients With Movement Disorders	Not yet recruiting	NCT03269201

Search NIH Clinical Center for Corticobasal Degeneration

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Genetic Tests for Corticobasal Degeneration

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Anatomical Context for Corticobasal Degeneration

MalaCards organs/tissues related to Corticobasal Degeneration:

³⁸

Cortex, Brain, Tongue, Eye, Spinal Cord, Thalamus

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Publications for Corticobasal Degeneration

Articles related to Corticobasal Degeneration:

(show top 50) (show all 418)

#	Title	Authors	Year
1	Corticobasal degeneration: key emerging issues. ( 29063240 )	Ali F....Josephs K.A.	2018
2	The Neuropsychology (Broadly Conceived) of Multiple System Atrophy, Progressive Supranuclear Palsy, and Corticobasal Degeneration. ( 28961692 )	Gerstenecker A.	2017
3	Apathy in corticobasal degeneration: possible parietal involvement. ( 29306357 )	Moretti R....Signori R.	2017
4	Levodopa-responsive depression associated with corticobasal degeneration: a case report. ( 28458551 )	Tarakita N....Yasui-Furukori N.	2017
5	An autopsied case of corticobasal degeneration presenting with frontotemporal dementia followed by myoclonus. ( 28707717 )	Iwasaki Y....Yoshida M.	2017
6	Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease. ( 28235814 )	Day G.S....Morris J.C.	2017
7	Cognitive dysfunction in corticobasal degeneration. ( 28813088 )	Oliveira L.M....Munhoz R.P.	2017
8	Disentangling the neural correlates of corticobasal syndrome and corticobasal degeneration with systematic and quantitative ALE meta-analyses. ( 28649612 )	Albrecht F....Schroeter M.L.	2017
9	Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. ( 28271184 )	Yokoyama J.S....Desikan R.S.	2017
10	Progressive supranuclear palsy and corticobasal degeneration: Diagnostic challenges and clinicopathological considerations. ( 27561438 )	Eusebio A....Azulay J.P.	2016
11	Diagnoses of corticobasal syndrome and corticobasal degeneration. ( 26876110 )	Shimohata T....Nishizawa M.	2016
12	Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. ( 27815633 )	McMillan C.T....Grossman M.	2016
13	Presymptomatic anterior frontal involvement in corticobasal degeneration. ( 27913406 )	Kobylecki C....Mann D.M.	2016
14	Poster 332 Corticobasal Degeneration with Spastic Left Hemiparesis, Dystonic Posturing, and Rigidity: A Case Report. ( 27673088 )	Desai S.A....Zolotoy R.	2016
15	Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy. ( 26936765 )	Piras A....RAPnnbAock A.	2016
16	Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration. ( 27709685 )	Sanchez-Contreras M....Rademakers R.	2016
17	Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology. ( 27797812 )	Ling H....Revesz T.	2016
18	Visual signs and symptoms of corticobasal degeneration. ( 27553583 )	Armstrong R.A.	2016
19	Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. ( 27111692 )	Santos-Santos M.A....Gorno-Tempini M.L.	2016
20	Dopamine transporter imaging as a diagnostic modality for atypical Alzheimer's disease mimicking corticobasal degeneration. ( 26781839 )	Washida K....Toda T.	2016
21	Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. ( 27842611 )	Uchihara T....Kimura N.	2016
22	[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration. ( 27645292 )	Josephs K.A....Murray M.E.	2016
23	Fulminant corticobasal degeneration: Agrypnia excitata in corticobasal syndrome. ( 26873956 )	Rodriguez-Porcel F....Espay A.J.	2016
24	Incidental corticobasal degeneration. ( 27461552 )	MartA-nez-Maldonado A....Ferrer I.	2016
25	Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration. ( 26818518 )	Gentry E.G....Herskowitz J.H.	2016
26	Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options. ( 27526039 )	Lamb R....Morris H.R.	2016
27	Key emerging issues in progressive supranuclear palsy and corticobasal degeneration. ( 25701010 )	Josephs K.A.	2015
28	Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. ( 26077951 )	Kouri N....Dickson D.W.	2015
29	F-18 fluoro-d-glucose positron emission tomography/computed tomography in a patient with corticobasal degeneration. ( 25829747 )	Marti A.	2015
30	Progressive Dopamine Transporter Binding Loss in Autopsy-Confirmed Corticobasal Degeneration. ( 26485425 )	Pirker S....Pirker W.	2015
31	Pathological features of preclinical or early clinical stages of corticobasal degeneration: a comparison with advanced cases. ( 25708668 )	Nishida N....Kinoshita K.	2015
32	Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. ( 25534024 )	Boluda S....Trojanowski J.Q.	2015
33	Corticobasal degeneration: clinical characteristics and multidisciplinary therapeutic approach in 26 patients. ( 25917399 )	Shehata H.S....Fahmy E.	2015
34	Therapeutic interventions in parkinsonism: Corticobasal degeneration. ( 26382843 )	Marsili L....Colosimo C.	2015
35	In vivo decreased dopamine transporter uptake in corticobasal degeneration presenting with primary progressive aphasia without parkinsonism. ( 24919427 )	Gil-Navarro S....SA!nchez-Valle R.	2014
36	Diagnosis and treatment of corticobasal degeneration. ( 24469408 )	Armstrong M.J.	2014
37	Suppression of myoclonus in corticobasal degeneration by levetiracetam. ( 24926409 )	Cho J.W....Lee J.H.	2014
38	Apraxia in anti-GAD associated stiff person syndrome: Link to corticobasal degeneration? ( 25100431 )	Bowen L.N....Heilman K.M.	2014
39	Corticobasal degeneration initially developing motor versus non-motor symptoms: a comparative clinicopathological study. ( 25186621 )	Ikeda C....Uchitomi Y.	2014
40	Managing Advanced Progressive Supranuclear Palsy and Corticobasal Degeneration in a Palliative Care Unit: Admission Triggers and Outcomes. ( 25550443 )	BA1kki J....Lorenzl S.	2014
41	Corticobasal degeneration. ( 24963675 )	Grijalvo-Perez A.M....Litvan I.	2014
42	Validation of the new consensus criteria for the diagnosis of corticobasal degeneration. ( 24521567 )	Alexander S.K....Rowe J.B.	2014
43	A disease-specific metabolic brain network associated with corticobasal degeneration. ( 25208922 )	Niethammer M....Eidelberg D.	2014
44	Neuroleptic Malignant Syndrome in an Elderly Patient With Normal Pressure Hydrocephalus Overlapping Corticobasal Degeneration. ( 25280791 )	Isik A.T....Soysal P.	2014
45	Ultrastructural differences in pretangles between Alzheimer disease and corticobasal degeneration revealed by comparative light and electron microscopy. ( 25497147 )	Tatsumi S....Yoshida M.	2014
46	Argyrophilic grains are reliable disease-specific features of corticobasal degeneration. ( 24335531 )	Tatsumi S....Yoshida M.	2014
47	Astrocytic inclusions in progressive supranuclear palsy and corticobasal degeneration. ( 25124031 )	Yoshida M.	2014
48	Concomitant accumulation of I+-synuclein and TDP-43 in a patient with corticobasal degeneration. ( 25209854 )	Yamashita S....Ando Y.	2014
49	An autopsied case of corticobasal degeneration showing severe cerebral atrophy over a protracted disease course of 16 years. ( 25516199 )	Kondo D....Iseki E.	2014
50	Exome sequencing in familial corticobasal degeneration. ( 23867865 )	Fekete R....Ondo W.	2013

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Genes for Corticobasal Degeneration

Genes related to Corticobasal Degeneration (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Implication
1	MAPT	Microtubule Associated Protein Tau	Protein Coding	28.6	GeneCards inferred via : Disorders Publications (show sections)
2	RPS27A	Ribosomal Protein S27a	Protein Coding	17.98	GeneCards inferred via : Publications (show sections)
3	PGAM1	Phosphoglycerate Mutase 1	Protein Coding	17.78	GeneCards inferred via : Publications (show sections)
4	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	17.78	GeneCards inferred via : Publications (show sections)
5	CRYAB	Crystallin Alpha B	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
6	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
7	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
8	LRRK2	Leucine Rich Repeat Kinase 2	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
9	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
10	TARDBP	TAR DNA Binding Protein	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
11	KIF13B	Kinesin Family Member 13B	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
12	PITX3	Paired Like Homeodomain 3	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
13	GBA	Glucosylceramidase Beta	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
14	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	17.43	GeneCards inferred via : Publications (show sections)
15	CFL1	Cofilin 1	Protein Coding	7.78	GeneCards inferred via : Publications (show sections)
16	PRDX5	Peroxiredoxin 5	Protein Coding	7.78	GeneCards inferred via : Publications (show sections)
17	CSF3	Colony Stimulating Factor 3	Protein Coding	7.43	GeneCards inferred via : Publications (show sections)
18	MOBP	Myelin-Associated Oligodendrocyte Basic Protein	Protein Coding	7.43	GeneCards inferred via : Publications (show sections)
19	HSPB2	Heat Shock Protein Family B (Small) Member 2	Protein Coding	7.43	GeneCards inferred via : Publications (show sections)
20	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	7.43	GeneCards inferred via : Publications (show sections)

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Variations for Corticobasal Degeneration

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Expression for Corticobasal Degeneration

Search GEO for disease gene expression data for Corticobasal Degeneration.

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Pathways for Corticobasal Degeneration

Pathways related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁶	12.66	MTOR ROCK1 ROCK2 RPS6KB1 SOS1
2	Neuroscience ⁴	12.43	LRRK2 MAPT RPS27A TARDBP UCHL1
3	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²¹ Leptin signaling pathway ¹	12.25	MTOR ROCK1 ROCK2 RPS6KB1 SOS1
4	EphB-EphrinB Signaling ⁶⁰ Show member pathways Cytoskeleton remodeling Reverse signaling by ephrin B ²¹ Ephrin-Eph Signaling ⁶⁰	12.21	MAPT ROCK1 ROCK2 SOS1
5	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	11.94	CFL1 MAPT MTOR RPS6KB1
6	EGF/EGFR Signaling Pathway ¹	11.87	CFL1 MTOR ROCK1 RPS6KB1 SOS1
7	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	11.51	MTOR RPS6KB1 SOS1
8	Proteoglycans in cancer ³⁶	11.41	HSPB2 MTOR ROCK1 ROCK2 RPS6KB1 SOS1
9	G-protein signaling TC21 regulation pathway ²¹ Show member pathways G-protein signaling M-RAS regulation pathway ²¹ Negative feedback regulation of MAPK pathway ⁶²	11.36	CFL1 ROCK1 ROCK2 SOS1
10	TGF-beta Signaling Pathways ⁶¹	11.34	MTOR ROCK1 ROCK2 RPS6KB1 SOS1
11	RhoA signaling pathway ¹	11.25	CFL1 ROCK1 ROCK2
12	G-protein signaling_Cross-talk between Ras-family GTPases ²¹	11.15	MTOR ROCK1 ROCK2 RPS6KB1 SOS1
13	BDNF-TrkB Signaling ¹	11.14	MTOR RPS6KB1 SOS1
14	G13 Signaling Pathway ¹	11.07	CFL1 ROCK1 ROCK2 RPS6KB1
15	Insulin signalling in human adipocytes (normal condition) ¹ Show member pathways Insulin signalling in human adipocytes (diabetic condition) ¹	10.76	MTOR RPS6KB1
16	Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics ⁵⁷	10.72	MTOR RPS6KB1

Sources

GO Terms for Corticobasal Degeneration

Cellular components related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial outer membrane	GO:0005741	9.67	LRRK2 MTOR RPS27A RPS6KB1
2	axon	GO:0030424	9.65	CRYAB KIF13B LRRK2 MAPT UCHL1
3	myelin sheath	GO:0043209	9.62	CRYAB MOBP RPS27A UCHL1
4	cytosol	GO:0005829	9.5	CFL1 CRYAB HSPB2 KIF13B LRRK2 MAPT
5	neuronal cell body	GO:0043025	9.43	LRRK2 MAPT MTOR PITX3 SOS1 UCHL1
6	cytoplasm	GO:0005737	10.06	CFL1 CRYAB HSPB2 KIF13B LRRK2 MAPT

Biological processes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 25)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphorylation	GO:0006468	9.8	CFL1 LRRK2 MTOR ROCK1 ROCK2 RPS6KB1
2	regulation of cellular response to heat	GO:1900034	9.76	CRYAB MAPT MTOR
3	negative regulation of protein phosphorylation	GO:0001933	9.75	LRRK2 MTOR TARDBP
4	regulation of macroautophagy	GO:0016241	9.74	GBA MTOR UCHL1
5	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.69	ROCK1 ROCK2 RPS27A
6	Rho protein signal transduction	GO:0007266	9.67	CFL1 ROCK1 ROCK2
7	regulation of autophagy	GO:0010506	9.65	LRRK2 MAPT ROCK1
8	regulation of keratinocyte differentiation	GO:0045616	9.62	ROCK1 ROCK2
9	regulation of stress fiber assembly	GO:0051492	9.62	ROCK1 ROCK2
10	regulation of dendritic spine morphogenesis	GO:0061001	9.61	CFL1 LRRK2
11	TOR signaling	GO:0031929	9.61	MTOR RPS6KB1
12	cellular response to starvation	GO:0009267	9.61	GBA LRRK2 MTOR
13	negative regulation of macroautophagy	GO:0016242	9.59	LRRK2 MTOR
14	negative regulation of neuron death	GO:1901215	9.58	CSF3 GBA LRRK2
15	axonal transport of mitochondrion	GO:0019896	9.56	MAPT UCHL1
16	negative regulation of protein homooligomerization	GO:0032463	9.55	CRYAB GBA
17	regulation of mitochondrial fission	GO:0090140	9.54	LRRK2 MAPT
18	regulation of actin cytoskeleton organization	GO:0032956	9.54	MTOR ROCK1 ROCK2
19	intracellular distribution of mitochondria	GO:0048312	9.52	LRRK2 MAPT
20	regulation of establishment of endothelial barrier	GO:1903140	9.46	ROCK1 ROCK2
21	negative regulation of myosin-light-chain-phosphatase activity	GO:0035509	9.26	ROCK1 ROCK2
22	neuron projection arborization	GO:0140058	9.16	LRRK2 ROCK1
23	negative regulation of bicellular tight junction assembly	GO:1903347	8.96	ROCK1 ROCK2
24	response to amino acid	GO:0043200	8.8	CFL1 MTOR RPS6KB1
25	negative regulation of apoptotic process	GO:0043066	10	CFL1 CRYAB PRDX5 RPS27A RPS6KB1

Molecular functions related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase activity	GO:0004672	9.72	LRRK2 MTOR ROCK1 ROCK2 RPS6KB1
2	microtubule binding	GO:0008017	9.46	CRYAB KIF13B LRRK2 MAPT
3	protein serine/threonine kinase activity	GO:0004674	9.35	LRRK2 MTOR ROCK1 ROCK2 RPS6KB1
4	Rho GTPase binding	GO:0017048	8.8	LRRK2 ROCK1 ROCK2
5	protein binding	GO:0005515	10.19	CFL1 CRYAB GBA HSPB2 KIF13B LRRK2

Sources

Sources for Corticobasal Degeneration

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ ExPASy

¹⁷ FDA Approved Drugs

¹⁸ FMA

¹⁹ GeneAnalytics

²⁰ GeneCards

²¹ GeneGo (Thomson Reuters)

²² GeneHancer via GeneCards

²³ GeneReviews

²⁴ Genetics Home Reference

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HGMD

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ MalaCards

³⁹ MedGen

⁴⁰ MedlinePlus

⁴¹ MeSH

⁴² MESH via Orphanet

⁴³ MGI

⁴⁴ NCBI Bookshelf

⁴⁵ NCI

⁴⁶ NCIt

⁴⁷ NDF-RT

⁴⁸ NIH Clinical Center

⁴⁹ NIH Rare Diseases

⁵⁰ NINDS

⁵¹ Novoseek

⁵² Novus Biologicals

⁵³ OMIM

⁵⁴ OMIM via Orphanet

⁵⁵ Orphanet

⁵⁶ PathCards

⁵⁷ PharmGKB

⁵⁸ PubMed

⁵⁹ PubMed Health

⁶⁰ QIAGEN

⁶¹ R&D Systems

⁶² Reactome

⁶³ Sino Biological

⁶⁴ SNOMED-CT

⁶⁵ SNOMED-CT via HPO

⁶⁶ SNOMED-CT via Orphanet

⁶⁷ TGDB

⁶⁸ Tocris

⁶⁹ UMLS

⁷⁰ UMLS via Orphanet

⁷¹ UniProtKB/Swiss-Prot

⁷² Wikipedia