MCID: CRT033
MIFTS: 44

Corticobasal Degeneration malady

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Corticobasal Degeneration

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Aliases & Descriptions for Corticobasal Degeneration:

Name: Corticobasal Degeneration 46 47 66
Cortical-Basal Ganglionic Degeneration 46
 
Cortico-Basal Ganglionic Degeneration 46
Cbgd 46

Classifications:



Summaries for Corticobasal Degeneration

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NINDS:47 Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, (an absence of movements), (a resistance to imposed movement), (impaired balance); and limb (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, (muscular jerks), and (difficulty swallowing) may also occur. An individual with corticobasal degeneration eventually becomes unable to walk.

MalaCards based summary: Corticobasal Degeneration, also known as cortical-basal ganglionic degeneration, is related to pick disease and corticobasal degeneration, mapt-related. An important gene associated with Corticobasal Degeneration is MAPT (Microtubule Associated Protein Tau), and among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and EphB-EphrinB Signaling. Affiliated tissues include cortex, brain and tongue, and related mouse phenotypes are no phenotypic analysis and integument.

NIH Rare Diseases:46 Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. the cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. these symptoms develop and worsen over time. currently the cause of corticobasal degeneration is not known. last updated: 5/14/2015

Wikipedia:69 Corticobasal degeneration (CBD) or corticobasal ganglionic degeneration (CBGD) is a rare, progressive... more...

Related Diseases for Corticobasal Degeneration

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Diseases in the Corticobasal Degeneration family:

Corticobasal Degeneration, Mapt-Related

Diseases related to Corticobasal Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1pick disease31.5MAPT, RPS27A, TARDBP
2corticobasal degeneration, mapt-related12.1
3dementia, frontotemporal10.6
4apraxia10.6
5dementia10.5
6testicular seminoma10.5MAPT, TARDBP
7anti-p200 pemphigoid10.5MAPT, RPS27A, TARDBP
8andersen syndrome10.5MAPT, RPS27A, TARDBP
9aphasia10.4
10cerebritis10.4
11microsporidiosis10.4GBA, MAPT, TARDBP
12mast syndrome10.4MAPT, RPS27A, TARDBP
13parkinson disease 110.4GBA, MAPT, TARDBP
14neurodegeneration with optic atrophy, childhood onset10.4MAPT, UCHL1
15phka2-related phosphorylase kinase deficiency10.4GBA, MAPT, UCHL1
16allergic bronchopulmonary aspergillosis, familial10.3MAPT, RPS27A, TARDBP
17tauopathy10.3
18neuronitis10.3
19myoclonus10.3
20adrenal gland pheochromocytoma10.3MAPT, PITX3, RPS27A
21corticobasal syndrome10.3
22multiple system atrophy10.2
23alzheimer disease10.2
24creutzfeldt-jakob disease10.2
25multicentric reticulohistiocytosis10.2GBA, UCHL1
26cardiomyopathy, dilated, 1u10.2MAPT, RPS27A, TARDBP, UCHL1
27dystonia10.1
28suppurative thyroiditis10.1MAPT, TARDBP
29semantic dementia10.1
30leukocyte adhesion deficiency10.0CRYAB, PITX3
31myopathy, myofibrillar, fatal infantile hypertrophy, alpha-b crystallin-related10.0CRYAB, PITX3
32supranuclear palsy, progressive10.0
33basal ganglia calcification10.0
34lateral sclerosis10.0
35rem sleep behavior disorder10.0
36stiff-person syndrome9.8
37hydrocephalus9.8
38pulmonary fibrosis9.8
39arachnoiditis9.8
40parametritis9.8
41neuroleptic malignant syndrome9.8
42olivopontocerebellar atrophy9.8
43normal pressure hydrocephalus9.8
44antiphospholipid syndrome9.8
45complex regional pain syndrome9.8
46striatonigral degeneration9.8
47arachnoid cysts9.8
48neurosyphilis9.8
49progressive non-fluent aphasia9.8
50ataxia9.8

Graphical network of the top 20 diseases related to Corticobasal Degeneration:



Diseases related to corticobasal degeneration

Symptoms for Corticobasal Degeneration

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Drugs & Therapeutics for Corticobasal Degeneration

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Drugs for Corticobasal Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1cadexomer iodinePhase 4484
2
IodinePhase 45167553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
3UbiquinonePhase 2, Phase 3132
4
Coenzyme Q10NutraceuticalPhase 2, Phase 3108303-98-05281915
Synonyms:
(all-E)-2,3-dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31-octamethyl-2,6,10,14,18,22,26,30-dotriacontaoctaenyl)-2,5-Cyclohexadiene-1,4-dione
(all-E)-2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-p-Benzoquinone
2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl- 2,5-Cyclohexadiene-1,4-dione
4-Ethyl-5-fluoropyrimidine
Aqua Q 10L10
Aqua Q10
Bio-Quinon
Bio-Quinone Q10
CoQ10
Coenzyme Q-10
Coenzyme Q10
Ensorb
Kaneka Q10
 
Kudesan
Li-Q-Sorb
Liquid-Q
Neuquinon
Neuquinone
PureSorb Q 40
Q 10AA
Q-Gel
Q-Gel 100
Ubidecarenone
Ubiquinone 10
Ubiquinone 50
Ubiquinone Q10
Ubiquinone-10
Unbiquinone
Unispheres Q 10
5Lithium carbonatePhase 1, Phase 2222554-13-2
6
QuinidinePhase 24456-54-2441074
Synonyms:
(+)-quinidine
(-)-Quinine
(8R,9S)-Quinidine
(R)-(6-Methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol
(S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
(S)-(6-Methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol
11010-73-4
12239-42-8
128544-03-6
130-89-2
130-95-0
1407-83-6
21480-31-9
22600_FLUKA
22620_FLUKA
22620_SIGMA
50-54-4
500225-45-6
549-56-4
55980-20-6
56-54-2
572-59-8
6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
6119-70-6
6151-39-9
6151-40-2
6183-68-2
6591-63-5
6912-57-8
72646-90-3
767303-40-2
804-63-7
840482-04-4
845886-64-8
857212-53-4
864908-93-0
875538-34-4
882741-47-1
883881-01-4
888714-03-2
890027-24-4
894767-09-0
898813-59-7
898814-00-1
898814-28-3
899813-83-3
900786-66-5
900789-95-9
906550-97-8
909263-47-4
909767-48-2
909882-78-6
910878-25-0
910880-97-6
910899-51-3
911445-75-5
918778-04-8
AB00514657
AC1L199L
AC1L1ANE
AC1L1LHL
AC1L1R7Y
AC1L3RNZ
AC1L9AHT
AC1L9AHW
AC1LCUGN
AC1LDI43
AC1LDI46
AC1MBNAI
AC1MHDEF
AC1MHUCH
AC1MHWS7
AC1MI1Q5
AC1NSV55
AC1NSV58
AC1NSZYR
AC1NSZYU
AC1NUNML
AC1NUNMO
AC1NX8JM
AC1O56R7
AC1O7EE0
AC1O7GNZ
AC1OAH7Z
AC1OCD5W
AC1OCD62
AC1OFCPL
AC1Q4EZ5
AC1Q4EZ6
AC1Q58AF
AR-1A4833
AR-1H2065
Aflukin
Apo-Quinidine
Auriquin
BB_NC-0697
BIB1110
BIDD:GT0144
Biquin Durules
C06526
C06527
C20H24N2O2
CCRIS 5755
CCRIS 672
CHEBI:111177
CHEBI:15854
CHEBI:28593
CHEMBL170
CHEMBL21578
CHEMBL576997
CHEMBL601807
CHEMBL97
CID10448938
CID1065
CID25522
CID2728270
CID3000825
CID3032576
CID3034034
CID3036746
CID441073
CID441074
CID5317111
CID5317112
CID5320867
CID5320868
 
CID5484444
CID5484450
CID5748152
CID5953
CID637552
CID6453100
CID6602154
CID6604605
CID667448
CID667449
CID6857801
CID6916033
CID6916036
CID7048767
CID8549
CID94175
CID9967055
CIN-QUIN
CPD000857275
Cardioquin
Chinidin
Chinidine
Chinidinum
Chinin
Chinine
Cin-Quin
Coccinine
Coco-Quinine
Conchinin
Conchinine
Conquinine
D08458
D08460
DB00468
DB00908
Duraquin
Epiquinidine
FT-0082277
GNF-PF-5459
GNF-Pf-180
GNF-Pf-5423
HMS1304I22
HMS1607A11
HMS1989J09
HMS2089E05
HSDB 225
HSDB 2501
I14-3348
I14-3397
IBS-L0034250
IDI1_000134
KBio1_000134
KBio2_001392
KBio2_003960
KBio2_006528
KBio3_001551
KST-1A1085
Kinidin
Kinidin (TN)
L001278
LS-141252
LS-187236
LS-194958
LS-221
LS-4562
LT00645788
Lopac-Q-0875
Lopac-Q-1250
MLS001304041
MLS001335913
MLS001335914
NCI-C56246
NCI60_004320
NINDS_000134
NSC 192949
NSC 5362
NSC131458
NSC192949
NSC5362
NSC667852
Novoquinidin
OR28880
Pitayin
Pitayine
Q0006
Q3625_SIGMA
Quin-Release
Quinact
Quinaglute
Quinaglute Dura-Tabs
Quinalan
Quinate
Quinatime
Quindan
Quindine
Quinicardine
Quinidex
Quinidex Extentabs
Quinidina
Quinidine
Quinidine Gluconate
Quinidine Sulfate
Quiniduran
Quinimax
Quinine
Quinine Dab
Quinora
Quniacridine
RH01857
SAM002264644
SB01652
SMP1_000254
SMR000718748
SMR000857275
SPBio_001375
SPBio_002379
ST056282
TCMDC-131239
TNP00086
alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol
beta-Quinine
bmse000511
chinidinum
chininum
quinidina
quinidine
quinina
β-quinine
7
DextromethorphanPhase 2127125-71-35360696, 5362449
Synonyms:
( )-3-Methoxy-N-methylmorphinon
( )-cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4alpha-iminoethanophenanthren
(+)-3-Methoxy-17-methylmorphinan
(+)-dextromethorphan
(-)-3-Methoxy-N-methylmorphinan
(9alpha,13alpha,14alpha)-17-methyl-3-(methyloxy)morphinan
125-69-9 (hydrobromide)
125-70-2
125-71-3
18046-32-7
18609-21-7 (hydrochloride)
3-Methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan
3-Methoxy-17-methylmorphinan
32062-10-5
4-21-00-01367 (Beilstein Handbook Reference)
6700-34-1 (hydrobromide, mono-hydrate)
9alpha,13alpha,14alpha-Morphinan, 3-methoxy-17-methyl- (8CI)
AC-13098
AC1L1EYT
Albutussin
Antussan
BA 2666
BPBio1_000503
BRD-K33211335-337-03-7
BRN 0088549
BSPBio_000457
Balminil DM
Balminil DM Children
Bayer Select Flu Relief
Bayer Select Head & Chest Cold
Bayer Select Night Time Cold
Benylin Adult Formula Cough Suppressant
Benylin DM
Benylin DM (TN)
Benylin DM 12 Hour
Benylin DM for Children
Benylin DM for Children 12 Hour
Benylin Pediatric Cough Suppressant
C06947
CHEBI:128891
CHEBI:4470
CHEBI:580686
CHEMBL22207
CHEMBL52440
CID3008
CID5360696
CID5362449
Calmylin #1
Canfodion
Cerose-DM
Chloraseptic DM
Contac Day & Night Cold/Flu Day Caplets
Contac Jr. Non-drowsy Formula
Contac Nighttime Cold Medicine
Contac Severe Cold Formula Maximum Strength
Contac Severe Cold Formula Non-Drowsy
Coricidin Syrup
Cosylan
Cough-X
Creo-Terpin
D-Methorphan
D-Methorphan Hydrobromide
D-methorphan
D03742
DB00514
DEA No. 9210
DM
DXM
Delsym
Delsym Cough Formula
Delta-Methorphan
Demorphan
Demorphan Hydrobromide
Demorphan hydrobromide
Demorphine
Destrometerfano
Destrometerfano [DCIT]
Destrometerfano [Dcit]
Dex
Dextromethorfan
Dextromethorfan [Czech]
Dextromethorphan
Dextromethorphan (USP)
Dextromethorphan Bromhydrate
Dextromethorphan Bromide
Dextromethorphan [USP:INN:BAN]
Dextromethorphan hydrobromide OROS Tablets
Dextromethorphan hydrobromide [BAN:JAN]
Dextromethorphan hydrobromide monohydrate
Dextromethorphane
Dextromethorphane [INN-French]
Dextromethorphanum
Dextromethorphanum [INN-Latin]
Dextrometorfano
Dextrometorfano [INN-Spanish]
Dextrometorphan
Dextromorphan
Dextrométhorphane
Dexyromethorphan
Diabe-Tuss DM Syrup
 
Dimacol
Dimetapp DM
Dormetan
Dormethan
Drixoral Cough
Drixoral Cough & Congestion
Drixoral Cough & Sore Throat
EINECS 204-751-7
EINECS 204-752-2
Endotussin-NN
Endotussin-NN Pediatric
HMS2090C08
HSDB 3056
Hihustan M.
Hold
Hold DM
Koffex DM
L-Methorphan
LS-91837
LS-91838
Levomethorphan
Levomethorphan [BAN:DCF:INN]
Levomethorphan [Ban:Dcf:Inn]
Levomethorphan [INN:BAN:DCF]
Levomethorphane
Levomethorphane [INN-French]
Levomethorphanum
Levomethorphanum [INN-Latin]
Levometorfano
Levometorfano [INN-Spanish]
Lopac-D-2531
Lopac0_000337
MLS000758303
Medicon
Methorate
Methorate Hydrobromide
Methorphan
Metrorat
MolPort-003-940-943
MolPort-004-285-957
Morphinan, 3-methoxy-17-methyl-, (9-alpha,13-alpha,14-alpha)- (9CI)
NCGC00015333-01
NCGC00015333-02
NCGC00015333-04
NCGC00162126-01
Naldecon-DX
Novahistex DM
Novahistine DM
Ornex Severe Cold Formula
Orthoxicol
PediaCare 1
PediaCare Cough-Cold Formula
Pertussin CS Children's Strength
Pertussin DM Extra Strength
Prestwick0_000359
Prestwick1_000359
Prestwick2_000359
Prestwick3_000359
Prestwick_686
RACEMETHORPHAN
Robitussin CF
Robitussin Cold & Cough
Robitussin Cough Calmers
Robitussin DM
Robitussin Maximum Strength Cough
Robitussin Maximum Strength Cough Suppressant
Robitussin Pediatric
Robitussin Pediatric Cough
Robitussin Pediatric Cough & Cold
Robitussin Pediatric Cough Suppressant
Robitussin Pediatric Night Relief
Romilar
Rondec dm
Ru-Tuss Expectorant
SPBio_002378
St. Joseph Cough Syrup
Sucrets 4 Hour Cough Suppressant
Sudafed Cough Syrup
Triaminic
Triaminic DM Long Lasting for Children
Trind-DM
Trocal
Tusilan
Tussade
Tussar DM
Tussi-Organidin
Tussi-Organidin DM NR
Tussi-Organidin DM-S NR
Tylenol Cold No Drowsiness
Tylenol Cold and Flu Multi-Symptom
Tylenol Cold and Flu No Drowsiness
Tylenol Cough + Decongestant Liquid
Tylenol Cough Liquid
Tylenol Flu No Drowsiness Gelcaps
UNII-7355X3ROTS
Vicks 44 Cough Relief
Viro-Med
d-Methorphan
delta-Methorphan
dextromethorphan
l-Methorphan
8
PhenylpropanolaminePhase 260314838-15-426934
Synonyms:
(+)-Norephedrine
(+-)-Norephedrin
(+-)-Norephedrine
(+/-)-Norephedrin
(-)-Norephedrin
(-)-Norephedrine
(.+-.)-Norephedrine
(1R,2S)-Norephedrine
.psi.-Norephedrine
134-60-1
14838-15-4
16960-27-3
1926-74-5
2-amino-1-phenylpropan-1-ol
27818-48-0
282553_ALDRICH
317500_ALDRICH
36393-56-3
36393-57-4
37577-07-4
37577-28-9
48115-38-4
492-39-7
492-41-1
6891-23-2
700-65-2
74530_FLUKA
AB00375975
AB1001936
AC1L1C6K
AC1L1IYB
AC1L1UWH
AC1L4QZI
AC1Q59PM
AR-1J0987
AR-1J0988
Acutrim
Ami-Tex
BIDD:GT0376
BPBio1_000361
BRN 2802895
BRN 3196918
BSPBio_000327
BSPBio_003292
C02343
C07911
C16719
C9H13NO
CHEBI:327494
CHEMBL136560
CID10297
CID162265
CID26934
CID4786
Cathina
Cathine
Cathine [INN]
Cathinum
Cathinum [INN-Latin]
Codimal
Conex
Contuss
D-(+)-Norephedrine
D08368
DB00397
DEA No. 1230
DL-Norephedrine
DL-Phenylpropanolamine
Despec
Dexatrim
DivK1c_000795
DivK1c_007030
Dura-Vent
EINECS 207-754-1
EINECS 207-755-7
EINECS 211-850-9
EINECS 238-900-2
EINECS 253-014-6
Exponcit
Fansia
Fansia (TN)
Fenilpropanolamina
Fugoa
Fugoa Depot
Gentab
Guaipax
HMS2090P12
HSDB 6485
Hydriatine
I01-8913
I01-8924
IDI1_000795
KBio1_000795
KBio1_001974
KBio2_001583
KBio2_004151
 
KBio2_006719
KBio3_001778
KBio3_002512
KBioGR_001385
KBioGR_001950
KBioSS_001583
Katine
L-(-)-Norephedrine
L-NOREPHEDRINE
L-Phenyl Propanolamine
L001077
LS-176795
LS-97284
LS-97285
LS-97461
LS-97462
Minusine
MolPort-001-769-340
MolPort-001-788-006
MolPort-001-794-194
MolPort-001-794-233
Mucorama
Mucron
Mydriatin
Myminic
NCGC00178157-01
NCGC00178157-02
NINDS_000795
NSC 17704
NSC 9920
NSC120735
NSC17704
NSC9920
Nobese
Nolex
Norephedrin
Norephedrine
Norpseudoephedrine
Obestat
PDSP1_001348
PDSP1_001349
PDSP1_001354
PDSP2_001332
PDSP2_001333
PDSP2_001338
PPA
Partuss
Phenoxine
Phenyldrine
Phenylfenesin
Phenylpropanolamin
Phenylpropanolamina
Phenylpropanolamine
Phenylpropanolaminum
Phénylpropanolamine
Prestwick0_000324
Prestwick1_000324
Prestwick2_000324
Prestwick3_000324
Prestwick_388
Propadrine
Propagest
Pseudonorephedrine
Rhindecon
Rhymed
SPBio_000051
SPBio_000471
SPBio_002248
SPECTRUM2300253
Snaplets
SpecPlus_000934
Spectrum2_000016
Spectrum2_000516
Spectrum3_000889
Spectrum3_001706
Spectrum4_000983
Spectrum4_001685
Spectrum5_000330
Spectrum5_001156
Spectrum_001103
Super Odrinex
TAVIST-D
ULR
UNII-33RU150WUN
UNII-E1L4ZW2F8O
USAF CS-6
Vanex
WLN: ZY1&YQR
WLN: ZY1&YQR -L
d-Nor-psi-ephedrine
d-Norpseudoephedrine
dl-Norephedrine
l-Nor-psi-ephedrin
l-Nor-psi-ephedrine
l-Norephedrine
phenylpropanolamine
psi-Norephedrine
β-hydroxyamphetamine
9
GuaifenesinPhase 260393-14-13516
Synonyms:
3-(2-Methoxyphenoxy)-1,2-propanediol
3-(O-Methoxyphenoxy)-1,2-propanediol
3-(O-Methoxyphenoxy)-propanediol-1,2
3-O-Methoxyphenoxypropane 1:2-diol
Actifed C
Aeronesin
Amonidren
Amonidrin
Aresol
Benylin-E
Bronchol
Glycerin ether
Glycerin guaiacolate
Glycero-guaiacol ether
Glycerol a-(2-methoxyphenyl) ether
Glycerol a-(O-methoxyphenyl)ether
Glycerol a-guaiacyl ether
Glycerol a-guiacyl ether
Glycerol a-monoguaiacol ether
Glycerol guaiacolate
Glycerol mono(2-methoxyphenyl) ether
Glycerol-a-guajakolether
Glycerol-alpha-guajakolether
Glyceryl guaiacol
Glyceryl guaiacol ether
Glyceryl guaiacolate
Glyceryl guaiacolate ether
Glyceryl guaiacyl ether
Glyceryl guaicolate
Glyceryl guiacolate
 
Glycerylguaiacol
Guaiacol glycerol ether
Guaiacol glyceryl ether
Guaiacolglicerinetere
Guaiacuran
Guaiacurane
Guaiacyl glyceryl ether
Guaiamar
Guaianesin
Guaicol glycerine ether
Guaicol glyceryl ether
Guaifenesin
Guaifenesine
Guaiphenesin
Guaiphenesine
Guaiphesin
Hustosil
Methoxypropanediol
Methphenoxydiol
Metossipropandiolo
O-Methoxyphenyl glyceryl ether
Organidin NR
Pneumomist
Propanosedyl
Reduton
Robitussin
a-Glyceryl guaiacol ether
a-Glyceryl guaiacolate ether
alpha-Glyceryl guaiacol ether
alpha-Glyceryl guaiacolate ether
guaiphenesin
p-Cresyl acetate
10taxanePhase 1335

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1DaTSCAN Imaging in Aging and Neurodegenerative DiseaseEnrolling by invitationNCT01453127Phase 4
2Effects of Coenzyme Q10 in PSP and CBDCompletedNCT00532571Phase 2, Phase 3
3A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal DegenerationCompletedNCT00703677Phase 1, Phase 2
4The Differential Diagnosis of Parkinson's Disease and Parkinsonism by Positron-emission TomographyCompletedNCT01824056Phase 2
5Electrical Polarization of the Brain in Corticobasal SyndromeCompletedNCT00273897Phase 2
6Safety, Tolerability and Efficacy of AVP-786 for the Treatment of DisinhibitionRecruitingNCT02534038Phase 2
7Davunetide (AL-108) in Predicted Tauopathies - Pilot StudyActive, not recruitingNCT01056965Phase 2
8Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy VolunteersCompletedNCT02167594Phase 1
9Safety Study of TPI-287 to Treat CBS and PSPRecruitingNCT02133846Phase 1
10Repetitive Transcranial Magnetic Stimulation (TMS) for Progressive Supranuclear Palsy and Corticobasal DegenerationCompletedNCT01174771
11Study of Tongue PressuresCompletedNCT00013832
12PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UKRecruitingNCT02778607
13Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)RecruitingNCT02365922
14Study for the Early Diagnosis of Parkinson's DiseaseRecruitingNCT02283073
15Parkinson's Disease, Diagnostic Observations (PADDO)RecruitingNCT01249768
164 Repeat Tauopathy Neuroimaging InitiativeActive, not recruitingNCT01804452
17Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders, PD,Essential Tremor, (ET),Cortical Basal Degeneration, (CBD),Multiple Systems Atrophy (MSA), MagnetoencephalographyActive, not recruitingNCT02132052
18The Sunnybrook Dementia Study: Mapping Brain Changes in Alzheimer's, Vascular and Other DementiasActive, not recruitingNCT01800214
19Innovative Biomarkers in Alzheimer's Disease and Frontotemporal Dementia (FTD): Preventative and PersonalizedNot yet recruitingNCT01403519
20SudoScan as a Biomarker of Parkinson's DiseaseNot yet recruitingNCT02767037

Search NIH Clinical Center for Corticobasal Degeneration

Genetic Tests for Corticobasal Degeneration

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Anatomical Context for Corticobasal Degeneration

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MalaCards organs/tissues related to Corticobasal Degeneration:

34
Cortex, Brain, Tongue, Eye, Spinal cord, Thalamus

Animal Models for Corticobasal Degeneration or affiliated genes

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MGI Mouse Phenotypes related to Corticobasal Degeneration:

39 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8CFL1, KIF13B, MAPT, MTOR, PITX3, SOS1
2MP:00107718.4CFL1, CSF3, GBA, MAPT, PITX3, ROCK1
3MP:00053918.2CFL1, CRYAB, MAPT, PITX3, ROCK1, ROCK2
4MP:00053698.0CRYAB, MAPT, MTOR, ROCK1, ROCK2, RPS6KB1
5MP:00053877.4CSF3, GBA, MAPT, MTOR, PITX3, ROCK1
6MP:00053977.3CSF3, GBA, MAPT, MTOR, PITX3, ROCK1
7MP:00053846.9CFL1, CRYAB, GBA, HSPB2, MAPT, MTOR
8MP:00053856.9CFL1, GBA, HSPB2, MAPT, PITX3, ROCK1
9MP:00053866.8CFL1, CRYAB, GBA, HSPB2, MAPT, MOBP
10MP:00036316.7CFL1, GBA, HSPB2, MAPT, MOBP, MTOR
11MP:00053786.6CFL1, GBA, MAPT, MTOR, PITX3, ROCK1

Publications for Corticobasal Degeneration

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Articles related to Corticobasal Degeneration:

(show top 50)    (show all 402)
idTitleAuthorsYear
1
Incidental corticobasal degeneration. (27461552)
2016
2
Fulminant corticobasal degeneration: Agrypnia excitata in corticobasal syndrome. (26873956)
2016
3
Therapeutic interventions in parkinsonism: Corticobasal degeneration. (26382843)
2015
4
A disease-specific metabolic brain network associated with corticobasal degeneration. (25208922)
2014
5
Corticobasal degeneration. (24963675)
2014
6
Analysis of PITX3 gene in patients with multisystem atrophy, progressive supranuclear palsy and corticobasal degeneration. (23694789)
2013
7
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration. (23121727)
2013
8
A case of an arachnoid cyst masquerading as corticobasal degeneration. (23061395)
2012
9
Acalculia in autopsy-proven corticobasal degeneration. (21321355)
2011
10
A proteomic study identifies different levels of light chain ferritin in corticobasal degeneration and progressive supranuclear palsy. (22012136)
2011
11
Clinicopathological correlations in corticobasal degeneration. (21823158)
2011
12
Corticobasal degeneration presenting as complex regional pain syndrome. (19224616)
2009
13
Corticobasal degeneration: clinical aspects. (18631773)
2008
14
Dysfunctional facial emotional expression and comprehension in a patient with corticobasal degeneration. (17786775)
2007
15
Corticobasal degeneration. (18808957)
2007
16
The clinical overlap between the corticobasal degeneration syndrome and other diseases of the frontotemporal spectrum: three case reports. (17726244)
2007
17
Categorization of novel animals by patients with Alzheimer's disease and corticobasal degeneration. (17402819)
2007
18
Links between frontotemporal lobar degeneration, corticobasal degeneration, progressive supranuclear palsy, and amyotrophic lateral sclerosis. (18090421)
2007
19
Corticobasal degeneration and progressive aphasia. (17060571)
2006
20
Constant and severe involvement of Betz cells in corticobasal degeneration is not consistent with pyramidal signs: a clinicopathological study of ten autopsy cases. (15735950)
2005
21
Decreased beta-amyloid peptide42 in cerebrospinal fluid of patients with progressive supranuclear palsy and corticobasal degeneration. (15992827)
2005
22
Neurosyphilis masquerading as corticobasal degeneration. (15389980)
2004
23
Presentation of Creutzfeldt-Jakob disease as acute corticobasal degeneration syndrome. (15300662)
2004
24
Gestural imitation and limb apraxia in corticobasal degeneration. (15177822)
2004
25
Cholinergic neuronal loss in the basal forebrain and mesopontine tegmentum of progressive supranuclear palsy and corticobasal degeneration. (12536222)
2003
26
Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction. (14581681)
2003
27
Distal-proximal differences in limb apraxia in corticobasal degeneration but not progressive supranuclear palsy. (14598093)
2003
28
Coherence analysis in the myoclonus of corticobasal degeneration. (14639679)
2003
29
Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration. (12084445)
2002
30
Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy. (11303763)
2001
31
Comparison of brain perfusion in corticobasal degeneration and Alzheimer's disease. (11244217)
2001
32
Rhythmic cortical and muscle discharges induced by fatigue in corticobasal degeneration. (10699413)
2000
33
Immunohistochemistry distinguishes: between Pick's disease and corticobasal degeneration. (11185644)
2000
34
Neuropsychiatric aspects of corticobasal degeneration. (10624478)
2000
35
The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. (11087783)
2000
36
Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease. (10965796)
2000
37
Cerebral blood flow in corticobasal degeneration and progressive supranuclear palsy. (10718204)
2000
38
Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms. (10037497)
1999
39
Dyspraxia in a patient with corticobasal degeneration: the role of visual and tactile inputs to action. (10449556)
1999
40
Apraxia differs in corticobasal degeneration and left-parietal stroke: A case study. (10413564)
1999
41
Heterogeneity of glucose metabolism in corticobasal degeneration. (9879684)
1998
42
Neuropsychological and neuroimaging correlates in corticobasal degeneration. (10933454)
1998
43
Increased CSF tau protein in corticobasal degeneration. (9457628)
1998
44
Paired helical filaments in corticobasal degeneration: the fine fibrillary structure with NanoVan. (9409702)
1997
45
Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy. (8702002)
1996
46
Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy. (7572077)
1995
47
Morphological overlap between corticobasal degeneration and Pick's disease: a clinicopathological report. (7885345)
1995
48
Unusual case of corticobasal degeneration with tau/Gallyas-positive neuronal and glial tangles. (7879609)
1994
49
Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy. (7526285)
1994
50
Corticobasal degeneration: decreased and asymmetrical glucose consumption as studied with PET. (1484530)
1992

Variations for Corticobasal Degeneration

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Expression for genes affiliated with Corticobasal Degeneration

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Search GEO for disease gene expression data for Corticobasal Degeneration.

Pathways for genes affiliated with Corticobasal Degeneration

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Pathways related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.5MTOR, ROCK1, ROCK2
2
Show member pathways
9.4MAPT, ROCK1, ROCK2, SOS1
39.4CFL1, ROCK1, ROCK2
4
Show member pathways
9.4CFL1, ROCK1, ROCK2
59.4CFL1, ROCK1, ROCK2
69.2MAPT, RPS6KB1, SOS1
7
Show member pathways
9.2MAPT, RPS6KB1, SOS1
8
Show member pathways
9.2CFL1, MAPT, ROCK1, ROCK2
99.2CFL1, MAPT, ROCK1, ROCK2
109.2CFL1, ROCK1, ROCK2, SOS1
119.1MTOR, RPS6KB1, SOS1
12
Show member pathways
9.1MTOR, RPS6KB1, SOS1
138.7CFL1, MAPT, MTOR, RPS6KB1
148.6CFL1, ROCK1, ROCK2, RPS6KB1
15
Show member pathways
8.5MTOR, ROCK1, ROCK2, RPS6KB1, SOS1
168.5MTOR, ROCK1, ROCK2, RPS6KB1, SOS1
17
Show member pathways
8.5MTOR, ROCK1, ROCK2, RPS6KB1, SOS1
188.0HSPB2, MTOR, ROCK1, ROCK2, RPS6KB1, SOS1

GO Terms for genes affiliated with Corticobasal Degeneration

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Cellular components related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.3CRYAB, KIF13B, MAPT, UCHL1
2myelin sheathGO:00432099.1CRYAB, MOBP, PGAM1, RPS27A, UCHL1
3cytosolGO:00058295.7CRYAB, HSPB2, KIF13B, MAPT, MTOR, PGAM1

Biological processes related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of bicellular tight junction assemblyGO:190334710.5ROCK1, ROCK2
2negative regulation of myosin-light-chain-phosphatase activityGO:003550910.5ROCK1, ROCK2
3regulation of establishment of endothelial barrierGO:190314010.5ROCK1, ROCK2
4regulation of stress fiber assemblyGO:005149210.4ROCK1, ROCK2
5regulation of keratinocyte differentiationGO:004561610.4ROCK1, ROCK2
6regulation of establishment of cell polarityGO:200011410.4ROCK1, ROCK2
7smooth muscle contractionGO:000693910.3ROCK1, ROCK2
8negative regulation of intracellular transportGO:003238710.3CRYAB, MAPT
9regulation of focal adhesion assemblyGO:005189310.1ROCK1, ROCK2
10I-kappaB kinase/NF-kappaB signalingGO:000724910.1ROCK1, ROCK2, RPS27A
11Rho protein signal transductionGO:00072669.8CFL1, ROCK1, ROCK2
12regulation of actin cytoskeleton organizationGO:00329569.6MTOR, ROCK1, ROCK2
13response to nutrientGO:00075849.4MAPT, MTOR, RPS6KB1
14TOR signalingGO:00319299.2MTOR, RPS6KB1
15negative regulation of apoptotic processGO:00430668.2CFL1, CRYAB, PRDX5, RPS27A, RPS6KB1

Molecular functions related to Corticobasal Degeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055154.7CFL1, CRYAB, GBA, HSPB2, KIF13B, MAPT

Sources for Corticobasal Degeneration

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet