MCID: CGH001
MIFTS: 37

Cough Variant Asthma malady

Summaries for Cough Variant Asthma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards: Cough Variant Asthma is related to asthma and bronchitis. An important gene associated with Cough Variant Asthma is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Inflammatory Response Pathway. The compounds ivig and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Aliases & Classifications for Cough Variant Asthma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

cough variant asthma 8 61


External Ids:

Disease Ontology8 DOID:12323
SNOMED-CT57 409663006
ICD9CM27 493.82

Related Diseases for Cough Variant Asthma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.6IGHE, NGF, RNASE3, IL10, IL5, IL4
2bronchitis30.5IGHE, RNASE3, IL5
3allergic asthma30.4IGHE, NGF, RNASE3, IL10, IL5, IL4
4allergic bronchopulmonary aspergillosis30.2IL4, IL5, IGHE
5allergic rhinitis30.2IL4, IL5, RNASE3, IGHE
6pulmonary function10.3
7aspergillosis10.2
8cystic fibrosis10.0RNASE3
9bronchopulmonary dysplasia10.0RNASE3
10eosinophilic esophagitis10.0IL5
11esophagitis10.0IL5
12mycosis fungoides10.0IL5
13eosinophilic fasciitis10.0IL5
14eye disease10.0NGF
15graves' disease10.0IL4
16cholera10.0NGF
17neuropathy10.0NGF
18malaria10.0IL10
19cystitis10.0NGF
20inflammatory bowel disease10.0IL10
21paracoccidioidomycosis10.0IL10
22pancreatitis10.0IL10
23acute pancreatitis10.0IL10
24common cold10.0RNASE3
25galactosemia10.0IL10
26schizophrenia10.0NGF
27hepatitis c10.0IL10
28onchocerciasis10.0IL5, RNASE3
29churg-strauss syndrome10.0IL5, RNASE3
30keratoconjunctivitis10.0RNASE3, IL5
31intraocular lymphoma10.0IL10
32sarcoidosis10.0ACE
33otitis media10.0IGHE, RNASE3
34chronic eosinophilic pneumonia10.0IL5, RNASE3
35myocardial infarction10.0ACE
36conjunctivitis10.0RNASE3, IGHE
37giant papillary conjunctivitis10.0RNASE3, IL5
38autoimmune lymphoproliferative syndrome10.0IL10
39filariasis10.0IL5, IGHE
40paragonimiasis10.0IGHE, IL5
41nephrotic syndrome10.0ACE
42eosinophilic gastroenteritis10.0IGHE, IL5
43nephritis10.0ACE
44acute myocardial infarction10.0ACE
45bronchiectasis10.0IGHE, RNASE3
46deficiency anemia10.0ACE
47anisakiasis10.0RNASE3, IGHE
48dilated cardiomyopathy10.0ACE
49mastocytosis10.0IL5, IGHE
50toxocariasis10.0IGHE, RNASE3

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to cough variant asthma

Clinical Features for Cough Variant Asthma

Drugs & Therapeutics for Cough Variant Asthma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cough Variant Asthma

Drug clinical trials:

Search ClinicalTrials for Cough Variant Asthma

Search NIH Clinical Center for Cough Variant Asthma

Search CenterWatch for Cough Variant Asthma

Genetic Tests for Cough Variant Asthma

Anatomical Context for Cough Variant Asthma

Sources:
33MalaCards
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MalaCards organs/tissues related to Cough Variant Asthma:

33
Endothelial

Animal Models for Cough Variant Asthma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cough Variant Asthma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1NGF, IGHE
2MP:00053708.2ACE, IL4, IL5, IL10
3MP:00053977.8IGHE, IL10, IL5, IL4, ACE
4MP:00053767.1ACE, IL4, IL5, IL10, NGF, IGHE

Publications for Cough Variant Asthma

Sources:
51PubMed
See all sources

Articles related to Cough Variant Asthma:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma. (24401902)
2013
2
Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. (24188204)
2013
3
Heightened cough response to bronchoconstriction in cough variant asthma. (22672909)
2012
4
Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. (22094623)
2012
5
Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma. (21447965)
2011
6
Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis. (20172262)
2010
7
Cough variant asthma and atopic cough. (22958894)
2010
8
TCM differential treatment of cough variant asthma. (20397466)
2010
9
Comparable effect of a leukotriene receptor antagonist and long-acting betaa88-adrenergic agonist in cough variant asthma. (20929598)
2010
10
Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids. (20671058)
2010
11
Effect of modified shegan mahuang decoction on cytokines in children patients with cough and variant asthma]. (20462055)
2010
12
Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study. (19272144)
2009
13
The efficacy of montelukast and airway mast cell profiles in patients with cough variant asthma. (18415834)
2008
14
Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma. (18399857)
2008
15
Methacholine vs adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma. (18394126)
2008
16
Effect of montelukast in a guinea pig model of cough variant asthma. (17369063)
2008
17
Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma. (17365202)
2007
18
Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough. (17426208)
2007
19
Pharmacotherapy of cough-variant asthma. (18001260)
2007
20
Wheeze detection as a measure of bronchial challenge in young children with cough-variant asthma and with classic asthma. (17590187)
2007
21
Prognosis of cough variant asthma: a retrospective analysis. (16517429)
2006
22
Roles of IL-4, IL-5 and IgE in childhood cough variant asthma]. (17052396)
2006
23
Longitudinal changes of pulmonary function and bronchial responsiveness in cough-variant asthma treated with bronchodilators alone. (17176782)
2006
24
Airway inflammation and cough sensitivity in cough-variant asthma. (16197473)
2005
25
Cough-variant asthma: responsive to integrative management and postural restoration. (16781569)
2005
26
Analysis of vascular endothelial growth factor levels in induced sputum samples from patients with cough variant asthma. (16200818)
2005
27
Prevalence and clinical features of cough variant asthma in a general internal medicine outpatient clinic in Japan. (15955149)
2005
28
Change in bronchial responsiveness and cough reflex sensitivity in patients with cough variant asthma: effect of inhaled corticosteroids. (16270932)
2005
29
Predictors for typical asthma onset from cough variant asthma. (15871442)
2005
30
Importance of atopic cough, cough variant asthma and sinobronchial syndrome as causes of chronic cough in the Hokuriku area of Japan. (15823186)
2005
31
Effectiveness of montelukast in the treatment of cough variant asthma. (15478381)
2004
32
Sputum eosinophil counts and eosinophil cationic protein levels in cough-variant asthma and in classic asthma, and their relationships to airway hypersensitivity or maximal airway response to methacholine. (15355463)
2004
33
Substance P-immunoreactive nerves in endobronchial biopsies in cough-variant asthma and classic asthma. (12584391)
2003
34
Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma? (12511712)
2003
35
Sputum eosinophilia in cough-variant asthma as a predictor of the subsequent development of classic asthma. (14519148)
2003
36
Longitudinal decline in pulmonary function in atopic cough and cough variant asthma. (12752586)
2003
37
Effect of suplatast tosilate, a Th2 cytokine inhibitor, on cough variant asthma. (12107601)
2002
38
Relationship of wheezing to airflow obstruction in asthmatic children and a history of cough-variant asthma. (12095180)
2002
39
A study of clinical features of cough variant asthma. (11408774)
2001
40
Sensory neuropeptides induce histamine release from bronchoalveolar lavage cells in both nonasthmatic coughers and cough variant asthmatics. (10651775)
2000
41
Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. (9308510)
1997
42
Cough variant asthma: a frequently overlooked clinical entity. (16892741)
1996
43
Allergic bronchopulmonary aspergillosis presenting with cough variant asthma and identifiable source of Aspergillus fumigatus. (7583851)
1995
44
Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests. (8203273)
1994
45
Outcome of cough variant asthma treated with inhaled steroids. (7998659)
1994
46
Cough variant asthma is associated with a higher wheezing threshold than classic asthma. (8221272)
1993
47
Cough variant asthma: a review of the clinical literature. (1672866)
1991
48
Cough-variant asthma in children and adults: case reports and review. (2096171)
1990
49
Cough variant asthma. (3786218)
1986
50
Cough variant asthma in children. (7053462)
1982

Genetic Variations for Cough Variant Asthma

Expression for genes affiliated with Cough Variant Asthma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cough Variant Asthma

Search GEO for disease gene expression data for Cough Variant Asthma.

Pathways for genes affiliated with Cough Variant Asthma

Sources:
53R&D Systems, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore
See all sources

Compounds for genes affiliated with Cough Variant Asthma

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Cough Variant Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1ivig4510.4IGHE
2ovomucoid4510.3IGHE
3hydrocortisone45 2 60 1113.3IGHE
4gm-csf45 2911.2IL10
5rantes459.9IL4, RNASE3
6monomethyl fumarate459.8IL4, IL10
7tolnaftate459.6IL5, IL4
8pranlukast45 29 1111.6RNASE3, IL5, IL4
9unicap459.6IL5, RNASE3, IGHE
10salmeterol45 50 29 1112.6RNASE3, IL4, IL5
11beclomethasone dipropionate459.6RNASE3, IGHE, IL5
12toluene diisocyanate459.5IL5, RNASE3, IGHE
13sodium cromoglycate459.5RNASE3, IGHE, IL5
14cetirizine45 29 11 2412.5RNASE3, IGHE, IL5
15ketotifen45 1110.5RNASE3, IL5, IGHE
16loteprednol45 1110.5IL5, IL4
17omalizumab45 1110.5IL5, IGHE, IL4
18glatiramer acetate45 1110.4IL10, IL5, IL4
19itraconazole45 1110.4IL5, IL4, IGHE
20il-12459.4IL5, IL4, IL10
21con a459.4IL4, IL10, IL5
22pgd2459.4IGHE, RNASE3, IL5
23polyinosinic-polycytidylic acid459.3IL10, IL5, IL4
24il 10459.3IL4, IL10, IL5
25cyclosporin a45 29 6011.2NGF, IGHE, RNASE3
26nedocromil sodium459.2RNASE3, IL5, IGHE, IL4
27azelastine45 1110.2IL4, IL5, RNASE3, IGHE
28budesonide45 50 1111.1IL5, IL4, IGHE, RNASE3
29fluticasone propionate45 50 60 1112.1RNASE3, IL5, IGHE, IL4
30methacholine45 1110.1IL5, IL4, IGHE, RNASE3
31salbutamol45 50 29 11 2413.1RNASE3, IL5, IGHE, IL10
32lidocaine45 29 1111.0IGHE, IL5, NGF
33tarc459.0IL5, IL10, IGHE, IL4
34prednisolone45 29 1110.8IGHE, NGF, RNASE3, IL5
35capsaicin45 299.8IL5, RNASE3, NGF, IGHE
36theophylline45 29 11 2411.7NGF, RNASE3, IL10, IL5
37infliximab45 50 1110.7IL4, IL10, IGHE
38praziquantel45 119.6IL10, IL5, RNASE3, IGHE, IL4
39montelukast45 50 29 1111.6IL5, IL4, RNASE3, IGHE, IL10
40allergens458.6IL10, IL5, IGHE, RNASE3, IL4
41aspirin45 50 29 2411.5ACE, NGF, RNASE3, IL4
42indomethacin45 60 29 1111.4NGF, IGHE, IL4, IL5
43sb 20358045 609.3NGF, IL4, IL10, IL5
44adenylate458.2NGF, IL5, RNASE3, IGHE, IL4
45vitamin d458.2IL5, IL10, IGHE, NGF
46thyroxine45 249.2IL10, IL4, IL5, NGF, IGHE
47arginine458.0IL5, NGF, RNASE3, IL4, IGHE
48histamine45 29 249.8IL4, IL5, IL10, NGF, IGHE, RNASE3
49dexamethasone45 50 29 1110.8IL4, IL5, IL10, RNASE3, NGF, IGHE
50vegf457.8IL4, IL5, RNASE3, NGF, IGHE, IL10

GO Terms for genes affiliated with Cough Variant Asthma

Sources:
16Gene Ontology
See all sources

Cellular components related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7NGF, RNASE3, IL5, ACE, IGHE
2extracellular spaceGO:0056157.3ACE, IL4, IL5, IL10, NGF

Biological processes related to Cough Variant Asthma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of isotype switchingGO:0451919.7IL4, IL10
2type 2 immune responseGO:0420929.7IL10, IL4
3positive regulation of MHC class II biosynthetic processGO:0453489.6IL4, IL10
4positive regulation of B cell proliferationGO:0308909.6IL4, IL5
5negative regulation of nitric oxide biosynthetic processGO:0450199.6IL4, IL10
6B cell differentiationGO:0301839.5IL4, IL10
7immune responseGO:0069558.8IL4, IL5, IGHE
8response to drugGO:0424938.7NGF, IL10, IL4
9inflammatory responseGO:0069548.6NGF, IL10, IL5
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.5IL4, IL5, IL10, NGF

Molecular functions related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL4, IL5, IL10
2growth factor activityGO:0080838.0IL4, IL5, IL10, NGF

Products for genes affiliated with Cough Variant Asthma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cough Variant Asthma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet