MCID: CGH001
MIFTS: 33

Cough Variant Asthma malady

Categories: Respiratory diseases

Aliases & Classifications for Cough Variant Asthma

Aliases & Descriptions for Cough Variant Asthma:

Name: Cough Variant Asthma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12323
ICD10 33 J45.991
ICD9CM 35 493.82
SNOMED-CT 64 409663006
UMLS 69 C0694548

Summaries for Cough Variant Asthma

Disease Ontology : 12 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards based summary : Cough Variant Asthma is related to asthma and restrictive cardiomyopathy. An important gene associated with Cough Variant Asthma is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Allograft rejection and Hematopoietic cell lineage. The drugs Budesonide and Procaterol have been mentioned in the context of this disorder. Affiliated tissues include endothelial and testes.

Related Diseases for Cough Variant Asthma

Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Related Disease Score Top Affiliating Genes
1 asthma 10.7
2 restrictive cardiomyopathy 10.2 IL5 RNASE3
3 renal hypertension 10.2 IL5 RNASE3
4 brown shrimp allergy 10.2 IL5 RNASE3
5 latent syphilis 10.2 IL5 RNASE3
6 necrotizing gastritis 10.2 IL5 RNASE3
7 benign meningioma 10.2 IL5 RNASE3
8 infectious anterior uveitis 10.2 IL5 RNASE3
9 anterior dislocation of lens 10.2 IL4 RNASE3
10 metal allergy 10.2 IL5 RNASE3
11 bile duct signet ring cell carcinoma 10.2 IL5 RNASE3
12 papillary squamous carcinoma 10.2 IL4 IL5
13 thelaziasis 10.2 IL4 IL5
14 hypersensitivity vasculitis 10.1 IL4 IL5
15 lymphoblastic leukemia 10.1 IL4 IL5
16 allescheriosis 10.1 IL4 IL5
17 urethral intrinsic sphincter deficiency 10.1 IL4 IL5
18 astrocytoma 10.1 IL5 RNASE3
19 bone peripheral neuroepithelioma 10.1 IL4 IL5
20 childhood malignant mesenchymoma 10.1 IL5 RNASE3
21 indian plum allergy 10.1 IL4 IL5
22 lactose intolerance 10.1 IL4 IL5
23 askin's tumor 10.1 IL4 IL5
24 pseudoinflammatory fundus dystrophy 10.1 NGF RNASE3
25 breast intracanalicular fibroadenoma 10.1 IL4 IL5
26 cutaneous fibrous histiocytoma 10.1 IL4 IL5
27 histoplasmosis retinitis 10.1 IL4 IL5
28 wilkes stevenson syndrome 10.1 IL5 RNASE3
29 lymphocytic gastritis 10.1 IL4 IL5
30 central nervous system origin vertigo 10.1 IL4 RNASE3
31 isolated klippel-feil syndrome 10.1 IL4 IL5
32 appendix carcinoid tumor 10.1 NGF RNASE3
33 dissociated nystagmus 10.1 IL4 IL5
34 duodenal somatostatinoma 10.1 IL4 IL5
35 coenurosis 10.1 IL4 IL5
36 abnormal retinal correspondence 10.1 IL4 IL5
37 hydrops of gallbladder 10.1 IL4 IL5
38 loiasis 10.1 IL4 IL5
39 familial renal papillary carcinoma 10.1 IL5 RNASE3
40 balkan nephropathy 10.1 IL4 IL5
41 mikulicz disease 10.1 IL4 NGF
42 dengue hemorrhagic fever 10.1 IL4 IL5
43 inflammatory bowel disease 2 10.0 IL4 IL5
44 parasitic protozoa infectious disease 10.0 IL4 IL5
45 dislocation of ear ossicle 10.0 LTC4S RNASE3
46 lens-induced iridocyclitis 10.0 IL4 IL5 RNASE3
47 spastic paraplegia 3a, autosomal dominant 10.0 IL4 IL5 RNASE3
48 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.0 IL4 IL5 RNASE3
49 luminal breast carcinoma 10.0 IL4 IL5 RNASE3
50 acute gonococcal prostatitis 10.0 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to Cough Variant Asthma

Symptoms & Phenotypes for Cough Variant Asthma

Drugs & Therapeutics for Cough Variant Asthma

Drugs for Cough Variant Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 4 51333-22-3 63006 5281004
2
Procaterol Approved Phase 4 72332-33-3 688561
3
Ephedrine Approved Phase 4 299-42-3 9294
4
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
5
Pseudoephedrine Approved Phase 4 90-82-4 7028
6
Montelukast Approved Phase 4 158966-92-8 5281040
7
Bambuterol Approved Phase 4 81732-65-2, 81732-46-9 54766
8
Terbutaline Approved Phase 4 23031-25-6 5403
9
Menthol Approved Phase 4 2216-51-5 16666
10 Adrenergic Agents Phase 4
11 Adrenergic Agonists Phase 4
12 Adrenergic beta-2 Receptor Agonists Phase 4
13 Adrenergic beta-Agonists Phase 4
14 Anti-Asthmatic Agents Phase 4
15 Autonomic Agents Phase 4
16 Bronchodilator Agents Phase 4
17 glucocorticoids Phase 4
18 Neurotransmitter Agents Phase 4
19 Peripheral Nervous System Agents Phase 4
20 Respiratory System Agents Phase 4
21 Adrenergic alpha-Agonists Phase 4
22 Anti-Obesity Agents Phase 4
23 Antitussive Agents Phase 4
24 Appetite Depressants Phase 4
25
Chlorpheniramine Phase 4 113-92-8, 132-22-9 2725
26 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
27 Expectorants Phase 4
28 Nasal Decongestants Phase 4
29 Vasoconstrictor Agents Phase 4
30 Budesonide, Formoterol Fumarate Drug Combination Phase 4
31 Formoterol Fumarate Phase 4
32 Hormone Antagonists Phase 4
33 Hormones Phase 4
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
35 Leukotriene Antagonists Phase 4
36 Tocolytic Agents Phase 4
37 Anti-Inflammatory Agents Phase 4
38 Cholinergic Agents Phase 4
39 Methacholine Chloride Phase 4
40
Azithromycin Approved 83905-01-5 55185 53477736 447043
41
Erythromycin Approved, Vet_approved 114-07-8 12560
42
Fenofibrate Approved 49562-28-9 3339
43
Mannitol Approved, Investigational 69-65-8 453 6251
44 Anti-Bacterial Agents
45 Anti-Infective Agents
46 Cephalosporins
47 Erythromycin Estolate
48 Erythromycin Ethylsuccinate
49 Erythromycin stearate
50 Gastrointestinal Agents

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4
2 Effects of Su-Huang Antitussive Capsule on Cough Variant Asthma Unknown status NCT01584804 Phase 4
3 Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma Unknown status NCT01404013 Phase 4
4 The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma Unknown status NCT02002754 Phase 4
5 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Recruiting NCT02934945 Phase 4
6 Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline Not yet recruiting NCT03105843 Phase 4
7 Effectiveness Study of Integrative Treatment for Pediatric Community Acquired Pneumonia Unknown status NCT02362906
8 Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Children Outpatients Completed NCT00660114
9 Case-control Study of Pandemic A/H1N1 Influenza Risk Factors In Lebanon Completed NCT01298206
10 Gene Expression Profile and Inflammation Profile of Classic Asthma, Cough Variant Asthma and Eosinophilic Bronchitis Recruiting NCT02555345
11 Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data Recruiting NCT03169699
12 Prescribing Asthma Controller Medication According to Gene Status to Improve Quality of Life in Young People With Asthma Recruiting NCT02758873
13 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting NCT01064245
14 Bronchodilating and Bronchoprotective Effects of Deep Inspirations Active, not recruiting NCT01659476

Search NIH Clinical Center for Cough Variant Asthma

Genetic Tests for Cough Variant Asthma

Anatomical Context for Cough Variant Asthma

MalaCards organs/tissues related to Cough Variant Asthma:

39
Endothelial, Testes

Publications for Cough Variant Asthma

Articles related to Cough Variant Asthma:

(show top 50) (show all 93)
id Title Authors Year
1
Diagnostic accuracy of fractional exhaled nitric oxide in predicting cough variant asthma and eosinophilic bronchitis in adult patients with chronic cough: A systematic review and meta-analysis. ( 28088474 )
2017
2
Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials. ( 27522988 )
2016
3
Clinical features in patients of cough variant asthma with normal and high level of exhaled fractional nitric oxide. ( 27731932 )
2016
4
"Cold air" and/or "talking" as cough triggers, a sign for the diagnosis of cough variant asthma. ( 27886852 )
2016
5
Correlational study on atmospheric concentrations of fine particulate matter and children cough variant asthma. ( 27383318 )
2016
6
Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma. ( 27055910 )
2016
7
Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma. ( 26169899 )
2015
8
Budesonide Suspension Nebulization Treatment in Chinese Pediatric Patients with Cough Variant Asthma: A Multi-center Observational Study. ( 26517446 )
2015
9
Cough-variant asthma: a diagnostic dilemma in the occupational setting. ( 25530078 )
2015
10
Cough variant asthma patients are more depressed and anxious than classic asthma patients. ( 25837530 )
2015
11
Letter to the Editor on Saito et al., "Cough variant asthma patients are more depressed and anxious than classic asthma patients.". ( 25959711 )
2015
12
Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma. ( 25329681 )
2014
13
A case of cough variant asthma undiagnosed for 16 years. ( 25988016 )
2014
14
Prof. Akio Niimi: the clinical identification of cough variant asthma. ( 25383214 )
2014
15
Matrix metalloproteinase 9 is involved in airway inflammation in cough variant asthma. ( 25187823 )
2014
16
[Diagnosis and treatment of cough variant asthma]. ( 24834548 )
2014
17
Clinical study on treatment of cough variant asthma by Chinese medicine. ( 23818206 )
2013
18
The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma. ( 23612495 )
2013
19
A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma. ( 24348708 )
2013
20
Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma. ( 24401902 )
2013
21
Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. ( 24188204 )
2013
22
[Levels of nerve growth factor and interleukin-4 in the induced sputum of children with cough variant asthma]. ( 23234779 )
2012
23
Heightened cough response to bronchoconstriction in cough variant asthma. ( 22672909 )
2012
24
Inflammatory mediators in induced sputum and airway hyperresponsiveness in cough variant asthma during long-term inhaled corticosteroid treatment. ( 22927709 )
2012
25
Superiority of nebulized corticosteroids over dry powder inhalers in certain patients with cough variant asthma or cough-predominant asthma. ( 22627846 )
2012
26
Cough variant asthma: lessons learned from deep inspirations. ( 22139550 )
2012
27
Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. ( 22094623 )
2012
28
Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma. ( 21447965 )
2011
29
Cough variant asthma and atopic cough. ( 22958894 )
2010
30
Comparable effect of a leukotriene receptor antagonist and long-acting betaa88-adrenergic agonist in cough variant asthma. ( 20929598 )
2010
31
TCM differential treatment of cough variant asthma. ( 20397466 )
2010
32
Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopic cough. ( 20299826 )
2010
33
Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids. ( 20671058 )
2010
34
Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis. ( 20172262 )
2010
35
Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study. ( 19272144 )
2009
36
Effect of montelukast in a guinea pig model of cough variant asthma. ( 17369063 )
2008
37
Methacholine vs adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma. ( 18394126 )
2008
38
The efficacy of montelukast and airway mast cell profiles in patients with cough variant asthma. ( 18415834 )
2008
39
Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma. ( 18399857 )
2008
40
Atopic features of cough variant asthma and classic asthma with wheezing. ( 17941915 )
2007
41
Wheeze detection as a measure of bronchial challenge in young children with cough-variant asthma and with classic asthma. ( 17590187 )
2007
42
Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma. ( 17365202 )
2007
43
Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough. ( 17426208 )
2007
44
Pharmacotherapy of cough-variant asthma. ( 18001260 )
2007
45
Expired breath condensate hydrogen peroxide concentration and pH for screening cough variant asthma among chronic cough. ( 19724670 )
2007
46
Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation. ( 17075251 )
2006
47
[Roles of IL-4, IL-5 and IgE in childhood cough variant asthma]. ( 17052396 )
2006
48
Longitudinal changes of pulmonary function and bronchial responsiveness in cough-variant asthma treated with bronchodilators alone. ( 17176782 )
2006
49
Prognosis of cough variant asthma: a retrospective analysis. ( 16517429 )
2006
50
Predictors for typical asthma onset from cough variant asthma. ( 15871442 )
2005

Variations for Cough Variant Asthma

Expression for Cough Variant Asthma

Search GEO for disease gene expression data for Cough Variant Asthma.

Pathways for Cough Variant Asthma

GO Terms for Cough Variant Asthma

Biological processes related to Cough Variant Asthma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.26 IL4 IL5
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.16 IL4 IL5
3 positive regulation of B cell proliferation GO:0030890 8.96 IL4 IL5
4 innate immune response in mucosa GO:0002227 8.62 IL4 RNASE3

Molecular functions related to Cough Variant Asthma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 IL4 IL5 NGF

Sources for Cough Variant Asthma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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