MCID: CGH001
MIFTS: 42

Cough Variant Asthma malady

Summaries for Cough Variant Asthma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards: Cough Variant Asthma is related to asthma and bronchitis. An important gene associated with Cough Variant Asthma is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Inflammatory Response Pathway. The compounds ivig and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include testes and endothelial, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Aliases & Classifications for Cough Variant Asthma

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

cough variant asthma 8 60


External Ids:

Disease Ontology8 DOID:12323
SNOMED-CT56 409663006
ICD9CM27 493.82

Related Diseases for Cough Variant Asthma

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17GeneCards, 18GeneDecks
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Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.6IGHE, NGF, RNASE3, IL10, IL5, IL4
2bronchitis30.4IGHE, RNASE3, IL5
3allergic asthma30.4IGHE, NGF, RNASE3, IL10, IL5, IL4
4allergic bronchopulmonary aspergillosis30.2IL4, IL5, IGHE
5rhinitis30.2IL4, IL5, RNASE3, IGHE
6allergic rhinitis30.2IL4, IL5, RNASE3, IGHE
7eosinophilia30.2IGHE, NGF, RNASE3, IL10, IL5, IL4
8aspergillosis10.2
9cystic fibrosis10.0RNASE3
10bronchopulmonary dysplasia10.0RNASE3
11eosinophilic esophagitis10.0IL5
12esophagitis10.0IL5
13mycosis fungoides10.0IL5
14eosinophilic fasciitis10.0IL5
15eye disease10.0NGF
16graves' disease10.0IL4
17cholera10.0NGF
18neuropathy10.0NGF
19malaria10.0IL10
20cystitis10.0NGF
21inflammatory bowel disease10.0IL10
22paracoccidioidomycosis10.0IL10
23pancreatitis10.0IL10
24acute pancreatitis10.0IL10
25common cold10.0RNASE3
26galactosemia10.0IL10
27schizophrenia10.0NGF
28hepatitis c10.0IL10
29onchocerciasis10.0IL5, RNASE3
30churg-strauss syndrome10.0IL5, RNASE3
31keratoconjunctivitis10.0RNASE3, IL5
32intraocular lymphoma10.0IL10
33sarcoidosis10.0ACE
34otitis media10.0IGHE, RNASE3
35chronic eosinophilic pneumonia10.0IL5, RNASE3
36myocardial infarction10.0ACE
37conjunctivitis10.0RNASE3, IGHE
38giant papillary conjunctivitis10.0RNASE3, IL5
39autoimmune lymphoproliferative syndrome10.0IL10
40filariasis10.0IL5, IGHE
41paragonimiasis10.0IGHE, IL5
42nephrotic syndrome10.0ACE
43eosinophilic gastroenteritis10.0IGHE, IL5
44nephritis10.0ACE
45acute myocardial infarction10.0ACE
46bronchiectasis10.0IGHE, RNASE3
47deficiency anemia10.0ACE
48anisakiasis10.0RNASE3, IGHE
49dilated cardiomyopathy10.0ACE
50mastocytosis10.0IL5, IGHE

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to cough variant asthma

Clinical Features for Cough Variant Asthma

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Drugs & Therapeutics for Cough Variant Asthma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cough Variant Asthma

Drug clinical trials:

Search ClinicalTrials for Cough Variant Asthma

Search NIH Clinical Center for Cough Variant Asthma

Search CenterWatch for Cough Variant Asthma

Genetic Tests for Cough Variant Asthma

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Anatomical Context for Cough Variant Asthma

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32MalaCards
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MalaCards organs/tissues related to Cough Variant Asthma:

32
Testes, Endothelial

Animal Models for Cough Variant Asthma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cough Variant Asthma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1NGF, IGHE
2MP:00053708.2IL5, IL4, ACE, IL10
3MP:00053977.8ACE, IGHE, IL10, IL5, IL4
4MP:00053767.1IL10, IGHE, NGF, IL5, ACE, IL4

Publications for Cough Variant Asthma

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Sources:
50PubMed
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Articles related to Cough Variant Asthma:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma. (24401902)
2013
2
A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma. (24348708)
2013
3
Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. (24188204)
2013
4
The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma. (23612495)
2013
5
Heightened cough response to bronchoconstriction in cough variant asthma. (22672909)
2012
6
Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. (22094623)
2012
7
Superiority of nebulized corticosteroids over dry powder inhalers in certain patients with cough variant asthma or cough-predominant asthma. (22627846)
2012
8
Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma. (21447965)
2011
9
Cough variant asthma and atopic cough. (22958894)
2010
10
TCM differential treatment of cough variant asthma. (20397466)
2010
11
Comparable effect of a leukotriene receptor antagonist and long-acting betaa88-adrenergic agonist in cough variant asthma. (20929598)
2010
12
Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma. (18399857)
2008
13
Methacholine vs adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma. (18394126)
2008
14
Effect of montelukast in a guinea pig model of cough variant asthma. (17369063)
2008
15
Atopic features of cough variant asthma and classic asthma with wheezing. (17941915)
2007
16
Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough. (17426208)
2007
17
Pharmacotherapy of cough-variant asthma. (18001260)
2007
18
Wheeze detection as a measure of bronchial challenge in young children with cough-variant asthma and with classic asthma. (17590187)
2007
19
Prognosis of cough variant asthma: a retrospective analysis. (16517429)
2006
20
Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation. (17075251)
2006
21
Roles of IL-4, IL-5 and IgE in childhood cough variant asthma]. (17052396)
2006
22
Longitudinal changes of pulmonary function and bronchial responsiveness in cough-variant asthma treated with bronchodilators alone. (17176782)
2006
23
Maximal airway response to methacholine in cough-variant asthma: comparison with classic asthma and its relationship to peak expiratory flow variability. (16354858)
2005
24
Airway inflammation and cough sensitivity in cough-variant asthma. (16197473)
2005
25
Prevalence and clinical features of cough variant asthma in a general internal medicine outpatient clinic in Japan. (15955149)
2005
26
Change in bronchial responsiveness and cough reflex sensitivity in patients with cough variant asthma: effect of inhaled corticosteroids. (16270932)
2005
27
Predictors for typical asthma onset from cough variant asthma. (15871442)
2005
28
A guinea pig model for cough variant asthma and role of tachykinins. (15700549)
2004
29
Effectiveness of montelukast in the treatment of cough variant asthma. (15478381)
2004
30
Sputum eosinophil counts and eosinophil cationic protein levels in cough-variant asthma and in classic asthma, and their relationships to airway hypersensitivity or maximal airway response to methacholine. (15355463)
2004
31
Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma? (12511712)
2003
32
Sputum eosinophilia in cough-variant asthma as a predictor of the subsequent development of classic asthma. (14519148)
2003
33
Longitudinal decline in pulmonary function in atopic cough and cough variant asthma. (12752586)
2003
34
Childhood cough variant asthma and its relationship to classic asthma. (12839325)
2003
35
Effect of suplatast tosilate, a Th2 cytokine inhibitor, on cough variant asthma. (12107601)
2002
36
Case report: cough variant asthma. (12228961)
2002
37
The importance of maximal airway response to methacholine in the prediction of wheezing development in patients with cough-variant asthma. (12464045)
2002
38
A study of clinical features of cough variant asthma. (11408774)
2001
39
Development of wheezing in patients with cough variant asthma during an increase in airway responsiveness. (10515405)
1999
40
Diurnal variation of peak expiratory flow in children with cough variant asthma. (9576149)
1998
41
Eosinophilic inflammation in cough variant asthma. (9648956)
1998
42
Chronic airway inflammation and atopic features in cough variant asthma]. (10374453)
1997
43
Cough threshold for capsaicin increases by azelastine in patients with cough-variant asthma. (8843511)
1996
44
Cough variant asthma: a frequently overlooked clinical entity. (16892741)
1996
45
Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests. (8203273)
1994
46
Cough variant asthma is associated with a higher wheezing threshold than classic asthma. (8221272)
1993
47
Cough variant asthma: usefulness of a diagnostic-therapeutic trial with prednisone. (1471782)
1992
48
Cough variant asthma: a review of the clinical literature. (1672866)
1991
49
Cough-variant asthma in children and adults: case reports and review. (2096171)
1990
50
Cough variant asthma in children. (7053462)
1982

Genetic Variations for Cough Variant Asthma

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Expression for genes affiliated with Cough Variant Asthma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cough Variant Asthma

Search GEO for disease gene expression data for Cough Variant Asthma.

Pathways for genes affiliated with Cough Variant Asthma

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Cough Variant Asthma

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Cough Variant Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1ivig4410.4IGHE
2ovomucoid4410.3IGHE
3hydrocortisone44 2 59 1113.3IGHE
4gm-csf44 2811.2IL10
5rantes449.9IL4, RNASE3
6monomethyl fumarate449.8IL4, IL10
7tolnaftate449.6IL5, IL4
8pranlukast44 28 1111.6RNASE3, IL5, IL4
9unicap449.6IL5, RNASE3, IGHE
10salmeterol44 49 28 1112.6RNASE3, IL4, IL5
11beclomethasone dipropionate449.6RNASE3, IGHE, IL5
12toluene diisocyanate449.5IL5, RNASE3, IGHE
13sodium cromoglycate449.5RNASE3, IGHE, IL5
14cetirizine44 28 11 2412.5RNASE3, IGHE, IL5
15ketotifen44 1110.5RNASE3, IL5, IGHE
16loteprednol44 1110.5IL5, IL4
17omalizumab44 1110.5IL5, IGHE, IL4
18glatiramer acetate44 1110.4IL10, IL5, IL4
19itraconazole44 1110.4IL5, IL4, IGHE
20il-12449.4IL5, IL4, IL10
21con a449.4IL4, IL10, IL5
22pgd2449.4IGHE, RNASE3, IL5
23polyinosinic-polycytidylic acid449.3IL10, IL5, IL4
24il 10449.3IL4, IL10, IL5
25cyclosporin a44 28 5911.2NGF, IGHE, RNASE3
26nedocromil sodium449.2RNASE3, IL5, IGHE, IL4
27azelastine44 1110.2IL4, IL5, RNASE3, IGHE
28budesonide44 49 1111.1IL5, IL4, IGHE, RNASE3
29fluticasone propionate44 49 59 1112.1RNASE3, IL5, IGHE, IL4
30methacholine44 1110.1IL5, IL4, IGHE, RNASE3
31salbutamol44 49 28 11 2413.1RNASE3, IL5, IGHE, IL10
32lidocaine44 28 1111.0IGHE, IL5, NGF
33tarc449.0IL5, IL10, IGHE, IL4
34prednisolone44 28 1110.8IGHE, NGF, RNASE3, IL5
35capsaicin44 289.8IL5, RNASE3, NGF, IGHE
36theophylline44 28 11 2411.7NGF, RNASE3, IL10, IL5
37infliximab44 49 1110.7IL4, IL10, IGHE
38praziquantel44 119.6IL10, IL5, RNASE3, IGHE, IL4
39montelukast44 49 28 1111.6IL5, IL4, RNASE3, IGHE, IL10
40allergens448.6IL10, IL5, IGHE, RNASE3, IL4
41aspirin44 49 28 2411.5ACE, NGF, RNASE3, IL4
42indomethacin44 59 28 1111.4NGF, IGHE, IL4, IL5
43sb 20358044 599.3NGF, IL4, IL10, IL5
44adenylate448.2NGF, IL5, RNASE3, IGHE, IL4
45vitamin d448.2IL5, IL10, IGHE, NGF
46thyroxine44 249.2IL10, IL4, IL5, NGF, IGHE
47arginine448.0IL5, NGF, RNASE3, IL4, IGHE
48histamine44 28 249.8IL4, IL5, IL10, NGF, IGHE, RNASE3
49dexamethasone44 49 28 1110.8IL4, IL5, IL10, RNASE3, NGF, IGHE
50vegf447.8IL4, IL5, RNASE3, NGF, IGHE, IL10

GO Terms for genes affiliated with Cough Variant Asthma

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16Gene Ontology
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Cellular components related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7IGHE, NGF, RNASE3, IL5, ACE
2extracellular spaceGO:0056157.3NGF, IL10, IL5, IL4, ACE

Biological processes related to Cough Variant Asthma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of isotype switchingGO:0451919.7IL4, IL10
2type 2 immune responseGO:0420929.7IL4, IL10
3positive regulation of MHC class II biosynthetic processGO:0453489.6IL4, IL10
4positive regulation of B cell proliferationGO:0308909.6IL5, IL4
5negative regulation of nitric oxide biosynthetic processGO:0450199.6IL10, IL4
6B cell differentiationGO:0301839.5IL4, IL10
7immune responseGO:0069558.8IL5, IL4, IGHE
8response to drugGO:0424938.7NGF, IL10, IL4
9inflammatory responseGO:0069548.6IL10, NGF, IL5
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.5NGF, IL10, IL5, IL4

Molecular functions related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL4, IL5, IL10
2growth factor activityGO:0080838.0IL4, IL5, IL10, NGF

Products for genes affiliated with Cough Variant Asthma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Cough Variant Asthma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet