MCID: CGH001
MIFTS: 39

Cough Variant Asthma malady

Respiratory diseases category
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Summaries for Cough Variant Asthma

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Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards: Cough Variant Asthma is related to asthma and bronchitis. An important gene associated with Cough Variant Asthma is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Selected targets of GCR alpha. The compounds mometasone furoate and loteprednol have been mentioned in the context of this disorder. Affiliated tissues include testes and endothelial, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Cough Variant Asthma

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Sources:
8Disease Ontology, 62UMLS, 27ICD9CM, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

cough variant asthma 8 62


External Ids:

Disease Ontology8 DOID:12323
SNOMED-CT58 409663006
ICD9CM27 493.82

Related Diseases for Cough Variant Asthma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.5IL5, IL4, RNASE3, NGF, IGHE
2bronchitis30.7RNASE3
3allergic bronchopulmonary aspergillosis30.2IGHE, IL4, IL5
4rhinitis30.2IGHE, RNASE3, IL4, IL5
5allergic rhinitis30.2IL5, IL4, RNASE3, IGHE
6eosinophilia30.1IGHE, NGF, RNASE3, IL4, IL5
7pulmonary function10.4
8aspergillosis10.2
9endotheliitis10.2
10cystitis10.1NGF
11keratoconjunctivitis10.1IL5, RNASE3
12chronic eosinophilic pneumonia10.1IL5, RNASE3
13giant papillary conjunctivitis10.1RNASE3, IL5
14onchocerciasis10.1RNASE3, IL5
15churg-strauss syndrome10.1RNASE3, IL5
16cutaneous leishmaniasis10.0IL4, IL5
17conjunctivitis10.0IGHE, RNASE3
18sezary's disease10.0IL5, IL4
19paragonimiasis10.0IGHE, IL5
20anisakiasis10.0IGHE, RNASE3
21toxocariasis10.0RNASE3, IGHE
22leishmaniasis10.0IL5, IL4
23eosinophilic gastroenteritis10.0IGHE, IL5
24contact dermatitis10.0IGHE, IL5
25filariasis10.0IL5, IGHE
26cutaneous t cell lymphoma10.0IL5, IL4
27strongyloidiasis10.0IGHE, IL5
28bronchiectasis10.0RNASE3, IGHE
29otitis media10.0RNASE3, IGHE
30severe combined immunodeficiency10.0IL5, IL4
31mastocytosis10.0IGHE, IL5
32cork-handlers' disease10.0NGF, RNASE3, IL5
33respiratory failure10.0IGHE, RNASE3
34immunodeficiency with hyper igm type 110.0IGHE, IL4
35atopic dermatitis10.0NGF, RNASE3, IL4
36uveitis10.0ACE, IL4
37systemic scleroderma10.0IL4, ACE
38tetanus10.0IL4, IL5
39kimura disease10.0IGHE, RNASE3, IL5
40sinusitis10.0IL5, RNASE3, IGHE
41helminthiasis10.0IL5, RNASE3, IGHE
42eosinophilic pneumonia10.0IGHE, RNASE3, IL5
43hypereosinophilic syndrome10.0IL5, RNASE3, IGHE
44bronchiolitis10.0IGHE, RNASE3, IL5
45bullous pemphigoid10.0IL5, RNASE3, IGHE
46urticaria10.0IGHE, RNASE3, ACE
47multiple sclerosis10.0IL5, IL4, NGF
48autosomal dominant hyper ige syndrome10.0IGHE, RNASE3, IL4
49encephalomyelitis10.0IL4, NGF
50egg allergy10.0IGHE, IL4, IL5

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to cough variant asthma

Symptoms for Cough Variant Asthma

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Drugs & Therapeutics for Cough Variant Asthma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Cough Variant Asthma

Search NIH Clinical Center for Cough Variant Asthma

Genetic Tests for Cough Variant Asthma

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Anatomical Context for Cough Variant Asthma

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Sources:
33MalaCards
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MalaCards organs/tissues related to Cough Variant Asthma:

33
Testes, Endothelial

Animal Models for Cough Variant Asthma or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Cough Variant Asthma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5IL5, IL4, ACE, NGF, IGHE

Publications for Cough Variant Asthma

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Sources:
52PubMed
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Articles related to Cough Variant Asthma:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Clinical study on treatment of cough variant asthma by Chinese medicine. (23818206)
2013
2
Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma. (24401902)
2013
3
A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma. (24348708)
2013
4
Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. (24188204)
2013
5
Cough variant asthma: lessons learned from deep inspirations. (22139550)
2012
6
Heightened cough response to bronchoconstriction in cough variant asthma. (22672909)
2012
7
Inflammatory mediators in induced sputum and airway hyperresponsiveness in cough variant asthma during long-term inhaled corticosteroid treatment. (22927709)
2012
8
Levels of nerve growth factor and interleukin-4 in the induced sputum of children with cough variant asthma]. (23234779)
2012
9
Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma. (21447965)
2011
10
Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis. (20172262)
2010
11
Cough variant asthma and atopic cough. (22958894)
2010
12
TCM differential treatment of cough variant asthma. (20397466)
2010
13
Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopic cough. (20299826)
2010
14
Comparable effect of a leukotriene receptor antagonist and long-acting betaa88-adrenergic agonist in cough variant asthma. (20929598)
2010
15
Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids. (20671058)
2010
16
Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study. (19272144)
2009
17
The efficacy of montelukast and airway mast cell profiles in patients with cough variant asthma. (18415834)
2008
18
Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma. (18399857)
2008
19
Methacholine vs adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma. (18394126)
2008
20
Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma. (17365202)
2007
21
Expired breath condensate hydrogen peroxide concentration and pH for screening cough variant asthma among chronic cough. (19724670)
2007
22
Prognosis of cough variant asthma: a retrospective analysis. (16517429)
2006
23
Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation. (17075251)
2006
24
Maximal airway response to methacholine in cough-variant asthma: comparison with classic asthma and its relationship to peak expiratory flow variability. (16354858)
2005
25
Bronchial sensitivity and bronchial reactivity in children with cough variant asthma. (16236905)
2005
26
Airway inflammation and cough sensitivity in cough-variant asthma. (16197473)
2005
27
Characteristics of patients with chronic cough who developed classic asthma during the course of cough variant asthma: a longitudinal study. (16113512)
2005
28
Cough-variant asthma: responsive to integrative management and postural restoration. (16781569)
2005
29
Analysis of vascular endothelial growth factor levels in induced sputum samples from patients with cough variant asthma. (16200818)
2005
30
Prevalence and clinical features of cough variant asthma in a general internal medicine outpatient clinic in Japan. (15955149)
2005
31
Maximal airway plateau responses and eosinophils in cough variant asthma. (15355462)
2004
32
A guinea pig model for cough variant asthma and role of tachykinins. (15700549)
2004
33
Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma? (12511712)
2003
34
Sputum eosinophilia in cough-variant asthma as a predictor of the subsequent development of classic asthma. (14519148)
2003
35
Effect of suplatast tosilate, a Th2 cytokine inhibitor, on cough variant asthma. (12107601)
2002
36
Case report: cough variant asthma. (12228961)
2002
37
A study of clinical features of cough variant asthma. (11408774)
2001
38
Development of wheezing in patients with cough variant asthma during an increase in airway responsiveness. (10515405)
1999
39
Chronic airway inflammation and atopic features in cough variant asthma]. (10374453)
1997
40
Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. (9308510)
1997
41
Cough threshold for capsaicin increases by azelastine in patients with cough-variant asthma. (8843511)
1996
42
Allergic bronchopulmonary aspergillosis presenting with cough variant asthma and identifiable source of Aspergillus fumigatus. (7583851)
1995
43
Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests. (8203273)
1994
44
Outcome of cough variant asthma treated with inhaled steroids. (7998659)
1994
45
Cough variant asthma is associated with a higher wheezing threshold than classic asthma. (8221272)
1993
46
Cough variant asthma: usefulness of a diagnostic-therapeutic trial with prednisone. (1471782)
1992
47
Cough variant asthma: a review of the clinical literature. (1672866)
1991
48
Cough variant asthma. (2013562)
1991
49
Cough variant asthma. (3786218)
1986
50
Cough variant asthma in children. (7053462)
1982

Variations for Cough Variant Asthma

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Expression for genes affiliated with Cough Variant Asthma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cough Variant Asthma

Search GEO for disease gene expression data for Cough Variant Asthma.

Pathways for genes affiliated with Cough Variant Asthma

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Sources:
50PathCards, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 53QIAGEN, 54R&D Systems, 60Thomson Reuters
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Compounds for genes affiliated with Cough Variant Asthma

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Sources:
45Novoseek, 61Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 51PharmGKB, 3BitterDB
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Compounds related to Cough Variant Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1mometasone furoate45 6110.8IL5, RNASE3
2loteprednol45 1110.7IL4, IL5
3levocabastine45 29 1111.7RNASE3, IL5
4tolnaftate459.7IL5, IL4
5mometasone45 1110.6IL4, IL5
6oxatomide459.6IL5, IGHE
7anti-histamine459.5RNASE3, IGHE
8unicap459.5IL5, RNASE3, IGHE
9beclomethasone dipropionate459.5IL5, IGHE, RNASE3
10sodium cromoglycate459.5IGHE, RNASE3, IL5
11toluene diisocyanate459.5IGHE, RNASE3, IL5
12cetirizine45 29 24 1112.5IL5, RNASE3, IGHE
13ketotifen45 1110.5IGHE, IL5, RNASE3
14salbutamol45 51 29 24 1113.4IGHE, RNASE3, IL5
15pgd2459.4IGHE, IL5, RNASE3
16pranlukast45 29 1111.4IL4, IL5, RNASE3
17salmeterol45 51 29 1112.4RNASE3, IL4, IL5
18theophylline45 29 24 1112.3IL5, RNASE3, NGF
19lidocaine45 29 1111.3IGHE, IL5, NGF
20omalizumab45 1110.3IL4, IL5, IGHE
21ovomucoid459.3IL4, IL5, IGHE
22itraconazole45 1110.2IL5, IL4, IGHE
23tele-methylhistamine459.2RNASE3, IGHE
24tarc459.2IGHE, IL4, IL5
25ivig459.2IGHE, IL4, IL5
26morphine45 51 29 1112.1IL5, IGHE, NGF
27capsaicin45 2910.0RNASE3, IGHE, IL5, NGF
28prednisolone45 29 1111.0NGF, IGHE, IL5, RNASE3
29nedocromil sodium458.9IL4, IL5, IGHE, RNASE3
30praziquantel45 119.9IGHE, IL4, RNASE3, IL5
31azelastine45 119.9IGHE, IL5, IL4, RNASE3
32montelukast45 51 29 1111.9IL5, IL4, RNASE3, IGHE
33budesonide45 51 1110.9IGHE, RNASE3, IL5, IL4
34fluticasone propionate45 51 61 1111.9IL5, IL4, IGHE, RNASE3
35methacholine45 51 1110.9IL5, RNASE3, IL4, IGHE
36allergens458.9IL5, IL4, RNASE3, IGHE
37hydrocortisone45 3 61 1111.8IGHE, IL4, IL5
38thyroxine45 249.7IL4, NGF, IGHE, IL5
39chlorine45 249.7RNASE3, IGHE, ACE
40indomethacin45 29 61 1111.7IGHE, IL5, NGF, IL4
41cycloheximide458.5IL5, IL4, IGHE, NGF
42acetylcholine45 51 29 24 1112.5IGHE, NGF, ACE, RNASE3
43aspirin45 51 29 2411.5IL4, NGF, RNASE3, ACE
44creatinine458.4RNASE3, ACE, NGF, IGHE
45histamine45 29 2410.4IL4, NGF, IL5, RNASE3, IGHE
46cyclosporin a45 29 6110.4IL5, IL4, RNASE3, NGF, IGHE
47adenylate458.3NGF, IGHE, RNASE3, IL4, IL5
48dexamethasone45 51 29 1111.3IL5, IL4, IGHE, NGF, RNASE3
49vegf458.3IGHE, NGF, RNASE3, IL5, IL4
50arginine458.3IL5, IL4, RNASE3, NGF, IGHE

GO Terms for genes affiliated with Cough Variant Asthma

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Sources:
16Gene Ontology
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Cellular components related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1IL5, IL4, ACE, NGF
2extracellular regionGO:0055767.4IL5, ACE, RNASE3, NGF, IGHE

Biological processes related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.3IL4, NGF
2positive regulation of B cell proliferationGO:0308909.1IL5, IL4
3positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL5, IL4, NGF
4immune responseGO:0069558.8IGHE, IL4, IL5

Molecular functions related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.9IL5, IL4, NGF

Products for genes affiliated with Cough Variant Asthma

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  • Antibodies
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  • Antibodies

Sources for Cough Variant Asthma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet