MCID: CGH001
MIFTS: 36

Cough Variant Asthma

Categories: Respiratory diseases

Aliases & Classifications for Cough Variant Asthma

MalaCards integrated aliases for Cough Variant Asthma:

Name: Cough Variant Asthma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12323
ICD10 32 J45.991
ICD9CM 34 493.82
SNOMED-CT 64 409663006
UMLS 69 C0694548

Summaries for Cough Variant Asthma

Disease Ontology : 12 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards based summary : Cough Variant Asthma is related to bronchitis and allergic bronchopulmonary aspergillosis. An important gene associated with Cough Variant Asthma is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Allograft rejection and Hematopoietic cell lineage. The drugs Budesonide and Procaterol have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and lung.

Related Diseases for Cough Variant Asthma

Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 bronchitis 30.2 IL5 RNASE3
2 allergic bronchopulmonary aspergillosis 29.9 IL4 IL5
3 aspergillosis 29.8 IL4 IL5
4 allergic hypersensitivity disease 29.6 IL4 IL5 RNASE3
5 asthma 29.5 IL4 IL5 NGF RNASE3 TRPV1
6 allergic rhinitis 28.9 IL4 IL5 NGF RNASE3
7 rhinitis 28.0 IL4 IL5 NGF RNASE3 TRPV1
8 loeffler endocarditis 10.3 IL5 RNASE3
9 paragonimiasis 10.3 IL5 RNASE3
10 cow milk allergy 10.3 IL5 RNASE3
11 eosinophilic gastroenteritis 10.3 IL5 RNASE3
12 chronic eosinophilic pneumonia 10.3 IL5 RNASE3
13 status asthmaticus 10.3 IL5 RNASE3
14 sinusitis 10.3 IL5 RNASE3
15 cellulitis 10.3 IL5 RNASE3
16 pollen allergy 10.2 IL5 RNASE3
17 blepharoconjunctivitis 10.2 IL4 RNASE3
18 wells syndrome 10.2 IL5 RNASE3
19 churg-strauss syndrome 10.2 IL5 RNASE3
20 eosinophilic pneumonia 10.2 IL5 RNASE3
21 esophagitis, eosinophilic, 1 10.2 IL5 RNASE3
22 egg allergy 10.2 IL4 IL5
23 trichinosis 10.2 IL4 IL5
24 non-suppurative otitis media 10.2 IL4 IL5
25 scleritis 10.2 IL4 IL5
26 common cold 10.2 IL5 RNASE3
27 angiostrongyliasis 10.2 IL4 IL5
28 apple allergy 10.2 IL4 IL5
29 eosinophilic meningitis 10.2 IL4 IL5
30 cercarial dermatitis 10.2 IL4 IL5
31 intestinal schistosomiasis 10.2 IL4 IL5
32 eosinophilic gastritis 10.2 IL4 IL5
33 chronic tic disorder 10.2 IL4 IL5
34 folliculitis 10.2 IL4 IL5
35 toxic oil syndrome 10.2 IL4 IL5
36 prurigo nodularis 10.2 NGF RNASE3
37 primary amebic meningoencephalitis 10.2 IL4 IL5
38 vernal conjunctivitis 10.2 IL4 RNASE3
39 enterobiasis 10.2 IL4 IL5
40 conjunctival nevus 10.2 NGF RNASE3
41 paranasal sinus disease 10.1 IL4 IL5
42 paracoccidioidomycosis 10.1 IL4 IL5
43 allergic contact dermatitis 10.1 IL4 IL5
44 cutaneous leishmaniasis 10.1 IL4 IL5
45 contact dermatitis 10.1 IL4 IL5
46 bullous pemphigoid 10.0 IL5 RNASE3
47 otitis media 10.0 IL4 RNASE3
48 sezary's disease 10.0 IL4 IL5
49 keratoconjunctivitis sicca 10.0 IL4 NGF
50 atopic keratoconjunctivitis 9.9 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to Cough Variant Asthma

Symptoms & Phenotypes for Cough Variant Asthma

Drugs & Therapeutics for Cough Variant Asthma

Drugs for Cough Variant Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 4,Phase 1,Phase 2 51333-22-3 5281004 63006
2
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
3
Ephedrine Approved Phase 4 299-42-3 9294
4
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
5
Pseudoephedrine Approved Phase 4 90-82-4 7028
6
Montelukast Approved Phase 4 158966-92-8 5281040
7
Bambuterol Approved, Investigational Phase 4 81732-65-2, 81732-46-9 54766
8
Terbutaline Approved Phase 4 23031-25-6 5403
9
Menthol Approved Phase 4 2216-51-5 16666
10 Adrenergic Agents Phase 4,Phase 1,Phase 2
11 Adrenergic Agonists Phase 4,Phase 1,Phase 2
12 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 1,Phase 2
13 Adrenergic beta-Agonists Phase 4,Phase 1,Phase 2
14 Anti-Asthmatic Agents Phase 4,Phase 1,Phase 2
15 Autonomic Agents Phase 4,Phase 1,Phase 2
16 Bronchodilator Agents Phase 4,Phase 1,Phase 2
17 glucocorticoids Phase 4,Phase 1,Phase 2
18 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
19 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
20 Respiratory System Agents Phase 4,Phase 1,Phase 2
21 Adrenergic alpha-Agonists Phase 4
22 Anti-Obesity Agents Phase 4
23 Antitussive Agents Phase 4
24 Appetite Depressants Phase 4
25
Chlorpheniramine Phase 4 113-92-8, 132-22-9 2725
26 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
27 Expectorants Phase 4
28 Nasal Decongestants Phase 4
29 Vasoconstrictor Agents Phase 4
30 Budesonide, Formoterol Fumarate Drug Combination Phase 4,Phase 1,Phase 2
31 Formoterol Fumarate Phase 4,Phase 1,Phase 2
32 Hormone Antagonists Phase 4,Phase 1,Phase 2
33 Hormones Phase 4,Phase 1,Phase 2
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1,Phase 2
35 Leukotriene Antagonists Phase 4
36 Tocolytic Agents Phase 4
37 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
38 Cholinergic Agents Phase 4
39 Methacholine Chloride Phase 4
40
Fenofibrate Approved 49562-28-9 3339
41
Azithromycin Approved 83905-01-5 53477736 447043 55185
42
Erythromycin Approved, Investigational, Vet_approved 114-07-8 12560
43
Capsaicin Approved 404-86-4 1548943
44
Prednisone Approved, Vet_approved 53-03-2 5865
45
Mannitol Approved, Investigational 69-65-8 6251 453
46 Anti-Bacterial Agents
47 Anti-Infective Agents
48 Cephalosporins
49 Erythromycin Estolate
50 Erythromycin Ethylsuccinate

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4 Procaterol hydrochloride;Meptin placebo
2 Effects of Su-Huang Antitussive Capsule on Cough Variant Asthma Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
3 Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
4 The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
5 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Recruiting NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
6 Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline Not yet recruiting NCT03105843 Phase 4 Methacholine (MCh) Challenge Testing
7 Observation of Cough Variant Asthma Treated in Combination of Chanqin Granules. Not yet recruiting NCT03319043 Phase 1, Phase 2 Chanqin granules
8 Gene Expression Profile and Inflammation Profile of Classic Asthma, Cough Variant Asthma and Eosinophilic Bronchitis Unknown status NCT02555345
9 Effectiveness Study of Integrative Treatment for Pediatric Community Acquired Pneumonia Unknown status NCT02362906 Xiyanping injection;wind-heat formula granules;phlegm-heat formula granules;Fu-xiong San;second generation cephalosporin;Erythromycin;Azithromycin
10 Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Children Outpatients Completed NCT00660114
11 MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough Recruiting NCT03363698
12 Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data Recruiting NCT03169699
13 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting NCT01064245 high-dose methacholine challenge test
14 Bronchodilating and Bronchoprotective Effects of Deep Inspirations Active, not recruiting NCT01659476

Search NIH Clinical Center for Cough Variant Asthma

Genetic Tests for Cough Variant Asthma

Anatomical Context for Cough Variant Asthma

MalaCards organs/tissues related to Cough Variant Asthma:

38
Testes, Endothelial, Lung

Publications for Cough Variant Asthma

Articles related to Cough Variant Asthma:

(show top 50) (show all 97)
# Title Authors Year
1
Validity of Fractional Exhaled Nitric Oxide and Small Airway Function Indices in Diagnosis of Cough Variant Asthma. ( 28846444 )
2017
2
Correlation study of cough variant asthma and mycoplasma pneumonia infection in children. ( 28671088 )
2017
3
Diagnostic accuracy of fractional exhaled nitric oxide in predicting cough variant asthma and eosinophilic bronchitis in adult patients with chronic cough: A systematic review and meta-analysis. ( 28088474 )
2017
4
A lung sound analysis in a child thought to have cough variant asthma: A case report. ( 28673440 )
2017
5
Bronchoprotective effect of deep inspirations in cough variant asthma: A distinguishing feature in the spectrum of airway disease? ( 28917529 )
2017
6
Clinical features in patients of cough variant asthma with normal and high level of exhaled fractional nitric oxide. ( 27731932 )
2016
7
Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma. ( 27055910 )
2016
8
Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials. ( 27522988 )
2016
9
Correlational study on atmospheric concentrations of fine particulate matter and children cough variant asthma. ( 27383318 )
2016
10
"Cold air" and/or "talking" as cough triggers, a sign for the diagnosis of cough variant asthma. ( 27886852 )
2016
11
Cough-variant asthma: a diagnostic dilemma in the occupational setting. ( 25530078 )
2015
12
Therapeutic effects of naringin in a guinea pig model of ovalbumin-induced cough-variant asthma. ( 26169899 )
2015
13
Cough variant asthma patients are more depressed and anxious than classic asthma patients. ( 25837530 )
2015
14
Letter to the Editor on Saito et al., "Cough variant asthma patients are more depressed and anxious than classic asthma patients.". ( 25959711 )
2015
15
Budesonide Suspension Nebulization Treatment in Chinese Pediatric Patients with Cough Variant Asthma: A Multi-center Observational Study. ( 26517446 )
2015
16
Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma. ( 25329681 )
2014
17
Prof. Akio Niimi: the clinical identification of cough variant asthma. ( 25383214 )
2014
18
A case of cough variant asthma undiagnosed for 16 years. ( 25988016 )
2014
19
Matrix metalloproteinase 9 is involved in airway inflammation in cough variant asthma. ( 25187823 )
2014
20
[Diagnosis and treatment of cough variant asthma]. ( 24834548 )
2014
21
Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma. ( 24401902 )
2013
22
A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma. ( 24348708 )
2013
23
Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. ( 24188204 )
2013
24
The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma. ( 23612495 )
2013
25
Clinical study on treatment of cough variant asthma by Chinese medicine. ( 23818206 )
2013
26
Cough variant asthma: lessons learned from deep inspirations. ( 22139550 )
2012
27
[Levels of nerve growth factor and interleukin-4 in the induced sputum of children with cough variant asthma]. ( 23234779 )
2012
28
Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. ( 22094623 )
2012
29
Heightened cough response to bronchoconstriction in cough variant asthma. ( 22672909 )
2012
30
Inflammatory mediators in induced sputum and airway hyperresponsiveness in cough variant asthma during long-term inhaled corticosteroid treatment. ( 22927709 )
2012
31
Superiority of nebulized corticosteroids over dry powder inhalers in certain patients with cough variant asthma or cough-predominant asthma. ( 22627846 )
2012
32
Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma. ( 21447965 )
2011
33
Comparable effect of a leukotriene receptor antagonist and long-acting betaa88-adrenergic agonist in cough variant asthma. ( 20929598 )
2010
34
Cough variant asthma and atopic cough. ( 22958894 )
2010
35
TCM differential treatment of cough variant asthma. ( 20397466 )
2010
36
Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopic cough. ( 20299826 )
2010
37
Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids. ( 20671058 )
2010
38
Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis. ( 20172262 )
2010
39
Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study. ( 19272144 )
2009
40
Effect of montelukast in a guinea pig model of cough variant asthma. ( 17369063 )
2008
41
Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma. ( 18399857 )
2008
42
The efficacy of montelukast and airway mast cell profiles in patients with cough variant asthma. ( 18415834 )
2008
43
Methacholine vs adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma. ( 18394126 )
2008
44
Pharmacotherapy of cough-variant asthma. ( 18001260 )
2007
45
Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma. ( 17365202 )
2007
46
Wheeze detection as a measure of bronchial challenge in young children with cough-variant asthma and with classic asthma. ( 17590187 )
2007
47
Atopic features of cough variant asthma and classic asthma with wheezing. ( 17941915 )
2007
48
Expired breath condensate hydrogen peroxide concentration and pH for screening cough variant asthma among chronic cough. ( 19724670 )
2007
49
Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough. ( 17426208 )
2007
50
[Roles of IL-4, IL-5 and IgE in childhood cough variant asthma]. ( 17052396 )
2006

Variations for Cough Variant Asthma

Expression for Cough Variant Asthma

Search GEO for disease gene expression data for Cough Variant Asthma.

Pathways for Cough Variant Asthma

GO Terms for Cough Variant Asthma

Biological processes related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.13 IL4 IL5 NGF
2 positive regulation of B cell proliferation GO:0030890 8.62 IL4 IL5

Molecular functions related to Cough Variant Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 IL4 IL5 NGF

Sources for Cough Variant Asthma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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