MCID: CGH001
MIFTS: 40

Cough Variant Asthma malady

Respiratory diseases category
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Summaries for Cough Variant Asthma

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Disease Ontology:8 An asthma that is characterized by chronic nonproductive cough without shortness of breath.

MalaCards based summary: Cough Variant Asthma is related to bronchitis and asthma. An important gene associated with Cough Variant Asthma is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Selected targets of GCR alpha. The compounds mometasone furoate and loteprednol have been mentioned in the context of this disorder. Affiliated tissues include testes and endothelial, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Cough Variant Asthma

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Cough Variant Asthma, Aliases & Descriptions:

Name: Cough Variant Asthma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:12323
SNOMED-CT57 409663006
ICD9CM27 493.82

Related Diseases for Cough Variant Asthma

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Diseases related to Cough Variant Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1bronchitis31.2RNASE3
2asthma30.9IL5, IL4, RNASE3, NGF, IGHE
3allergic bronchopulmonary aspergillosis30.1IGHE, IL4, IL5
4rhinitis29.8IGHE, RNASE3, IL4, IL5
5allergic rhinitis29.8IL5, IL4, RNASE3, IGHE
6eosinophilia29.5IGHE, NGF, RNASE3, IL4, IL5
7pulmonary function10.4
8cystitis10.4NGF
9keratoconjunctivitis10.3IL5, RNASE3
10chronic eosinophilic pneumonia10.3IL5, RNASE3
11giant papillary conjunctivitis10.3RNASE3, IL5
12onchocerciasis10.2RNASE3, IL5
13churg-strauss syndrome10.2RNASE3, IL5
14aspergillosis10.2
15endotheliitis10.2
16cutaneous leishmaniasis10.1IL4, IL5
17conjunctivitis10.1IGHE, RNASE3
18sezary's disease10.1IL5, IL4
19paragonimiasis10.1IGHE, IL5
20anisakiasis10.1IGHE, RNASE3
21toxocariasis10.1RNASE3, IGHE
22leishmaniasis10.1IL5, IL4
23eosinophilic gastroenteritis10.1IGHE, IL5
24contact dermatitis10.1IGHE, IL5
25filariasis10.1IL5, IGHE
26cutaneous t cell lymphoma10.0IL5, IL4
27strongyloidiasis10.0IGHE, IL5
28bronchiectasis10.0RNASE3, IGHE
29otitis media10.0RNASE3, IGHE
30severe combined immunodeficiency10.0IL5, IL4
31mastocytosis10.0IGHE, IL5
32cork-handlers' disease10.0NGF, RNASE3, IL5
33respiratory failure10.0IGHE, RNASE3
34immunodeficiency with hyper igm type 110.0IGHE, IL4
35atopic dermatitis10.0NGF, RNASE3, IL4
36uveitis10.0ACE, IL4
37systemic scleroderma10.0IL4, ACE
38tetanus10.0IL4, IL5
39kimura disease9.9IGHE, RNASE3, IL5
40sinusitis9.9IL5, RNASE3, IGHE
41helminthiasis9.9IL5, RNASE3, IGHE
42eosinophilic pneumonia9.9IGHE, RNASE3, IL5
43hypereosinophilic syndrome9.9IL5, RNASE3, IGHE
44bronchiolitis9.9IGHE, RNASE3, IL5
45bullous pemphigoid9.9IL5, RNASE3, IGHE
46urticaria9.9IGHE, RNASE3, ACE
47multiple sclerosis9.9IL5, IL4, NGF
48autosomal dominant hyper ige syndrome9.8IGHE, RNASE3, IL4
49colitis9.8IL4, NGF
50egg allergy9.8IGHE, IL4, IL5

Graphical network of the top 20 diseases related to Cough Variant Asthma:



Diseases related to cough variant asthma

Symptoms for Cough Variant Asthma

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Drugs & Therapeutics for Cough Variant Asthma

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Drug clinical trials:

Search ClinicalTrials for Cough Variant Asthma

Search NIH Clinical Center for Cough Variant Asthma

Genetic Tests for Cough Variant Asthma

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Anatomical Context for Cough Variant Asthma

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MalaCards organs/tissues related to Cough Variant Asthma:

32
Testes, Endothelial

Animal Models for Cough Variant Asthma or affiliated genes

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MGI Mouse Phenotypes related to Cough Variant Asthma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5IL5, IL4, ACE, NGF, IGHE

Publications for Cough Variant Asthma

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Articles related to Cough Variant Asthma:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Matrix metalloproteinase 9 is involved in airway inflammation in cough variant asthma. (25187823)
2014
2
Diagnosis and treatment of cough variant asthma]. (24834548)
2014
3
Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma. (25329681)
2014
4
Clinical study on treatment of cough variant asthma by Chinese medicine. (23818206)
2013
5
Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma. (24401902)
2013
6
A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma. (24348708)
2013
7
Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. (24188204)
2013
8
The fractional exhaled nitric oxide and serum high sensitivity C-reactive protein levels in cough variant asthma and typical bronchial asthma. (23612495)
2013
9
Cough variant asthma: lessons learned from deep inspirations. (22139550)
2012
10
Heightened cough response to bronchoconstriction in cough variant asthma. (22672909)
2012
11
Inflammatory mediators in induced sputum and airway hyperresponsiveness in cough variant asthma during long-term inhaled corticosteroid treatment. (22927709)
2012
12
Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma. (21447965)
2011
13
Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis. (20172262)
2010
14
Cough variant asthma and atopic cough. (22958894)
2010
15
TCM differential treatment of cough variant asthma. (20397466)
2010
16
Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopic cough. (20299826)
2010
17
Comparable effect of a leukotriene receptor antagonist and long-acting betaa88-adrenergic agonist in cough variant asthma. (20929598)
2010
18
Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study. (19272144)
2009
19
The efficacy of montelukast and airway mast cell profiles in patients with cough variant asthma. (18415834)
2008
20
Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma. (18399857)
2008
21
Methacholine vs adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma. (18394126)
2008
22
Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma. (17365202)
2007
23
Prognosis of cough variant asthma: a retrospective analysis. (16517429)
2006
24
Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation. (17075251)
2006
25
Maximal airway response to methacholine in cough-variant asthma: comparison with classic asthma and its relationship to peak expiratory flow variability. (16354858)
2005
26
Bronchial sensitivity and bronchial reactivity in children with cough variant asthma. (16236905)
2005
27
Airway inflammation and cough sensitivity in cough-variant asthma. (16197473)
2005
28
Characteristics of patients with chronic cough who developed classic asthma during the course of cough variant asthma: a longitudinal study. (16113512)
2005
29
Cough-variant asthma: responsive to integrative management and postural restoration. (16781569)
2005
30
Analysis of vascular endothelial growth factor levels in induced sputum samples from patients with cough variant asthma. (16200818)
2005
31
Prevalence and clinical features of cough variant asthma in a general internal medicine outpatient clinic in Japan. (15955149)
2005
32
Maximal airway plateau responses and eosinophils in cough variant asthma. (15355462)
2004
33
A guinea pig model for cough variant asthma and role of tachykinins. (15700549)
2004
34
Substance P-immunoreactive nerves in endobronchial biopsies in cough-variant asthma and classic asthma. (12584391)
2003
35
Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma? (12511712)
2003
36
Sputum eosinophilia in cough-variant asthma as a predictor of the subsequent development of classic asthma. (14519148)
2003
37
Effect of suplatast tosilate, a Th2 cytokine inhibitor, on cough variant asthma. (12107601)
2002
38
Case report: cough variant asthma. (12228961)
2002
39
A study of clinical features of cough variant asthma. (11408774)
2001
40
Development of wheezing in patients with cough variant asthma during an increase in airway responsiveness. (10515405)
1999
41
Chronic airway inflammation and atopic features in cough variant asthma]. (10374453)
1997
42
Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. (9308510)
1997
43
Cough threshold for capsaicin increases by azelastine in patients with cough-variant asthma. (8843511)
1996
44
Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests. (8203273)
1994
45
Outcome of cough variant asthma treated with inhaled steroids. (7998659)
1994
46
Cough variant asthma is associated with a higher wheezing threshold than classic asthma. (8221272)
1993
47
Cough variant asthma: usefulness of a diagnostic-therapeutic trial with prednisone. (1471782)
1992
48
Cough variant asthma: a review of the clinical literature. (1672866)
1991
49
Cough-variant asthma in children and adults: case reports and review. (2096171)
1990
50
Cough variant asthma in children. (7053462)
1982

Variations for Cough Variant Asthma

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Expression for genes affiliated with Cough Variant Asthma

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Expression patterns in normal tissues for genes affiliated with Cough Variant Asthma

Search GEO for disease gene expression data for Cough Variant Asthma.

Pathways for genes affiliated with Cough Variant Asthma

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Compounds for genes affiliated with Cough Variant Asthma

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Compounds related to Cough Variant Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1mometasone furoate44 6110.8IL5, RNASE3
2loteprednol44 1110.7IL4, IL5
3levocabastine44 28 1111.7RNASE3, IL5
4tolnaftate449.7IL5, IL4
5mometasone44 1110.6IL4, IL5
6oxatomide449.6IL5, IGHE
7anti-histamine449.5RNASE3, IGHE
8unicap449.5IL5, RNASE3, IGHE
9beclomethasone dipropionate449.5IL5, IGHE, RNASE3
10sodium cromoglycate449.5IGHE, RNASE3, IL5
11toluene diisocyanate449.5IGHE, RNASE3, IL5
12cetirizine44 28 24 1112.5IL5, RNASE3, IGHE
13ketotifen44 1110.5IGHE, IL5, RNASE3
14salbutamol44 50 28 24 1113.4IGHE, RNASE3, IL5
15pgd2449.4IGHE, IL5, RNASE3
16pranlukast44 28 1111.4IL4, IL5, RNASE3
17salmeterol44 50 28 1112.4RNASE3, IL4, IL5
18theophylline44 28 24 1112.3IL5, RNASE3, NGF
19lidocaine44 28 1111.3IGHE, IL5, NGF
20omalizumab44 1110.3IL4, IL5, IGHE
21ovomucoid449.3IL4, IL5, IGHE
22itraconazole44 1110.2IL5, IL4, IGHE
23tele-methylhistamine449.2RNASE3, IGHE
24tarc449.2IGHE, IL4, IL5
25ivig449.2IGHE, IL4, IL5
26morphine44 50 28 1112.1IL5, IGHE, NGF
27capsaicin44 2810.0RNASE3, IGHE, IL5, NGF
28prednisolone44 28 1111.0NGF, IGHE, IL5, RNASE3
29nedocromil sodium448.9IL4, IL5, IGHE, RNASE3
30praziquantel44 119.9IGHE, IL4, RNASE3, IL5
31azelastine44 119.9IGHE, IL5, IL4, RNASE3
32montelukast44 50 28 1111.9IL5, IL4, RNASE3, IGHE
33budesonide44 50 1110.9IGHE, RNASE3, IL5, IL4
34fluticasone propionate44 50 61 1111.9IL5, IL4, IGHE, RNASE3
35methacholine44 50 1110.9IL5, RNASE3, IL4, IGHE
36allergens448.9IL5, IL4, RNASE3, IGHE
37hydrocortisone44 2 61 1111.8IGHE, IL4, IL5
38thyroxine44 249.7IL4, NGF, IGHE, IL5
39chlorine44 249.7RNASE3, IGHE, ACE
40indomethacin44 28 61 1111.7IGHE, IL5, NGF, IL4
41cycloheximide448.5IL5, IL4, IGHE, NGF
42acetylcholine44 50 28 24 1112.5IGHE, NGF, ACE, RNASE3
43aspirin44 50 28 2411.5IL4, NGF, RNASE3, ACE
44creatinine448.4RNASE3, ACE, NGF, IGHE
45histamine44 28 2410.4IL4, NGF, IL5, RNASE3, IGHE
46cyclosporin a44 28 6110.4IL5, IL4, RNASE3, NGF, IGHE
47adenylate448.3NGF, IGHE, RNASE3, IL4, IL5
48dexamethasone44 50 28 1111.3IL5, IL4, IGHE, NGF, RNASE3
49vegf448.3IGHE, NGF, RNASE3, IL5, IL4
50arginine448.3IL5, IL4, RNASE3, NGF, IGHE

GO Terms for genes affiliated with Cough Variant Asthma

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Cellular components related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1IL5, IL4, ACE, NGF
2extracellular regionGO:0055767.4IL5, ACE, RNASE3, NGF, IGHE

Biological processes related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.3IL4, NGF
2positive regulation of B cell proliferationGO:0308909.1IL5, IL4
3positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL5, IL4, NGF
4immune responseGO:0069558.8IGHE, IL4, IL5

Molecular functions related to Cough Variant Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.9IL5, IL4, NGF

Products for genes affiliated with Cough Variant Asthma

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  • Antibodies
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Sources for Cough Variant Asthma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet