MCID: CMR002
MIFTS: 49

Coumarin Resistance malady

Categories: Genetic diseases, Rare diseases, Metabolic diseases

Aliases & Classifications for Coumarin Resistance

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Aliases & Descriptions for Coumarin Resistance:

Name: Coumarin Resistance 50 24 68 12 66
Warfarin Resistance 50 46 24 68 48
Warfarin Sensitivity 50 46 24 66
Poor Metabolism of Coumarin 24 68
 
Coumadin Sensitivity 46 24
Warfarin Response 24 25
Drug Resistance 37
Cmres 68

Characteristics:

HPO:

62
coumarin resistance:
Inheritance: autosomal dominant inheritance


Classifications:



External Ids:

OMIM50 122700
MeSH37 D004351

Summaries for Coumarin Resistance

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NIH Rare Diseases:46 Warfarin sensitivity is a condition that is characterized by a reduced tolerance for a "blood-thinning" medication called warfarin. warfarin is an anticoagulant that is often prescribed to people who are at an increased risk for blood clots. people with a warfarin sensitivity respond more strongly to lower doses of warfarin and are, therefore, more likely to experience an overdose or other serious side effects from the medication. they may experience abnormal bleeding in the brain, gastrointestinal tract, or other tissues even at average doses. the metabolism of warfarin and the drug's effects in the body are complex traits that are determined by several genes as well as environmental and lifestyle factors such as gender, age, weight, diet, and other medications. two specific genetic polymorphisms in the cyp2c9 and vkorc1 genes account for approximately 30-40% of variation in the response to warfarin and can be passed on to future generations in an autosomal dominant manner. last updated: 6/18/2015

MalaCards based summary: Coumarin Resistance, also known as warfarin resistance, is related to f9-related altered drug metabolism and vkorc1-related altered drug metabolism, and has symptoms including abnormality of blood and blood-forming tissues and abnormality of metabolism/homeostasis. An important gene associated with Coumarin Resistance is VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1), and among its related pathways are Valproic Acid Pathway, Pharmacokinetics and Naphthalene metabolism. Affiliated tissues include heart and brain.

Genetics Home Reference:24 Warfarin sensitivity is a condition in which individuals have a low tolerance for the drug warfarin. Warfarin is an anticoagulant, which means that it thins the blood, preventing blood clots from forming. Warfarin is often prescribed to prevent blood clots in people with heart valve disease who have replacement heart valves, people with an irregular heart beat (atrial fibrillation), or those with a history of heart attack, stroke, or a prior blood clot in the deep veins of the arms or legs (deep vein thrombosis).

OMIM:50 Warfarin is a widely prescribed anticoagulant for the prevention of thromboembolic diseases for subjects with deep vein... (122700) more...

UniProtKB/Swiss-Prot:68 Coumarin resistance: A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement.

Related Diseases for Coumarin Resistance

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Graphical network of the top 20 diseases related to Coumarin Resistance:



Diseases related to coumarin resistance

Symptoms for Coumarin Resistance

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Symptoms by clinical synopsis from OMIM:

122700

Clinical features from OMIM:

122700

HPO human phenotypes related to Coumarin Resistance:

id Description Frequency HPO Source Accession
1 abnormality of blood and blood-forming tissues HP:0001871
2 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Coumarin Resistance

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Drugs for Coumarin Resistance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
WarfarinPhase 444181-81-26691, 54678486
Synonyms:
(-)-Warfarin
(S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone
(S)-Warfarin
(phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarin
(phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine
1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
200 Coumarin
200 coumarin
3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
3-(Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin
3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin
4-Hydroxy-3- (3-oxo-1-fenyl-butyl) cumarine
4-Hydroxy-3- (3-oxo-1-phenyl-butyl)-cumarin
4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine
4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
4-Idrossi-3- (3-oxo-)-fenil-butil)-cumarine
4-Idrossi-3-(3-oxo-)-fenil-butil)-cumarine
4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine
45706_FLUKA
45706_RIEDEL
4oh-coumarin deriv.
5543-56-6
5543-57-7
81-81-2
A2250_FLUKA
A2250_SIGMA
AC-15978
AC1L1N37
AC1Q6AN3
AR-1E2310
Arab Rat Death
Arab rat death
Arab rat deth
Athrombin
Athrombin-K
Athrombin-k
Athrombine-K
Athrombine-k
BRD-A24514565-001-02-2
BRD-A24514565-236-01-6
BRN 1293536
BSPBio_002026
Bio-0586
Brumolin
C01541
C19H16O4
CBDivE_002127
CBDivE_013236
CBKinase1_000192
CBKinase1_012592
CHEBI:10033
CHEMBL1464
CID6691
CO-Rax
Caswell No. 903
Choice
Choice (TN)
Co-Rax
Co-rax
Compound 42
Coumadin
Coumadin Tabs
Coumafen
Coumafene
Coumafene [French]
Coumaphen
Coumaphene
Coumarins
Coumefene
Cov-R-Tox
Cov-R-tox
D-Con
D08682
DB00682
DL-3-(alpha-acetonylbenzyl)-4-hydroxycoumarin
Dethmor
Dethnel
Dicusat E
Dicusat e
DivK1c_000444
EINECS 201-377-6
EINECS 226-907-3
EPA Pesticide Chemical Code 086002
Eastern states duocide
Fasco fascrat powder
Frass-Ratron
Frass-ratron
HMS1921K07
HMS2092C20
HMS501G06
HSDB 1786
I14-0958
IDI1_000444
Jantoven
KBio1_000444
KBio2_000674
KBio2_003242
KBio2_005810
KBio3_001526
KBioGR_000901
KBioSS_000674
Killgerm sewarin p
Kumader
Kumadu
Kumatox
Kypfarin
LS-55083
Latka 42
Latka 42 [Czech]
Liqua-tox
MLS001304042
Maag Rattentod Cum
Maag rattentod cum
Mar-Frin
Mar-frin
Marevan
Martin'S mar-frin
Martin's mar-frin
 
Maveran
MolPort-001-787-822
Mouse pak
NCGC00094810-01
NCGC00094810-02
NCGC00159398-03
NCGC00178855-01
NINDS_000444
NSC 59813
NSC59813
PS104_SUPELCO
Panwarfin
Place-Pax
Place-pax
Prothromadin
RAX
RCR grey squirrel killer concentrate
RCRA waste no. P001
Rat & mice bait
Rat and mice bait
Rat-B-gon
Rat-Gard
Rat-Kill
Rat-Mix
Rat-O-cide #2
Rat-O-cide no. 2
Rat-Ola
Rat-Trol
Rat-a-way
Rat-alpha-way
Rat-b-gon
Rat-beta-gon
Rat-gard
Rat-kill
Rat-mix
Rat-o-cide #2
Rat-ola
Rat-trol
Ratorex
Ratox
Ratoxin
Ratron
Ratron G
Ratron g
Rats-no-more
Ratten-Koederrohr
Ratten-koederrohr
Rattenstreupulver Neu Schacht
Rattenstreupulver neu schacht
Rattenstreupulver new schacht
Rattentraenke
Rattunal
Rcra waste number P001
Ro-Deth
Ro-deth
Rodafarin
Rodafarin C
Rodafarin c
Rodex
Rodex blox
Rosex
Rough & ready mouse mix
Rough and ready mouse mix
SMP1_000316
SMR000718754
SPBio_000870
SPECTRUM1500613
STK364490
Sakarat
Sewarin
Sofarin
Solfarin
Sorexa Plus
Sorexa plus
Spectrum2_000935
Spectrum3_000583
Spectrum4_000381
Spectrum5_001751
Spectrum_000194
Spray-trol brand roden-trol
Temus W
Temus w
Tintorane
Tox-Hid
Tox-hid
Twin light rat away
UNII-5Q7ZVV76EI
Vampirinip II
Vampirinip III
Vampirinip iii
W.A.R.F. 42
WARF compound 42
WLN: T66 BOVJ DYR&1V1 EQ
Waran
Warf 10
Warf 42
Warfarat
Warfarin (INN)
Warfarin (and salts of)
Warfarin Plus
Warfarin Q
Warfarin [BSI:ISO]
Warfarin [INN:BAN]
Warfarin plus
Warfarin plus [discontinued]
Warfarin sodium
Warfarin titrated to an INR of 2.5-3.0
Warfarin(R)
Warfarina
Warfarina [INN-Spanish]
Warfarine
Warfarine [INN-French]
Warfarine [ISO-French]
Warfarinum
Warfarinum [INN-Latin]
Warficide
Warfilone
Zoocoumarin
Zoocoumarin [Netherlands and USSR]
Zoocoumarin [Russian]
delta-Con
nchembio.307-comp19
rac-Warfarin
warfarin
2
PhenprocoumonPhase 429435-97-29908, 54680692
Synonyms:
2-hydroxy-3-(1-phenylpropyl)chromen-4-one
3-(1'-Phenyl-propyl)-4-oxycoumarin
3-(1'-Phenyl-propyl)-4-oxycoumarin [German]
3-(1-Phenylpropyl)-4-hydroxycoumarin
3-(alpha-Ethylbenzyl)-4-hydroxycoumarin
3-(alpha-Phenylpropyl)-4-hydroxycoumarin
4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
435-97-2
AC1L1U3E
AKOS002126557
BRN 1291115
CHEBI:117471
CHEBI:50438
CHEMBL1465
CHEMBL16694
CID9908
D010644
D05457
DB00946
EINECS 207-108-9
Falithiom
Falithrom
Fencumar
Fenprocoumona
Fenprocoumona [INN-Spanish]
Fenprocumon
Fenprocumone
Fenprocumone [DCIT]
 
HSDB 3248
Hexal Brand of Phenprocoumon
LS-55203
Liquamar
Liquamar (TN)
Marcoumar
Marcumar
Marcuphen
MolPort-005-935-554
Oprea1_002598
PHENPROCOUMON
Phenprocoumalol
Phenprocoumarol
Phenprocoumarole
Phenprocoumon (USAN/INN)
Phenprocoumon [USAN:INN:BAN]
Phenprocoumone
Phenprocoumone [INN-French]
Phenprocoumonum
Phenprocoumonum [INN-Latin]
Phenprocumone
Phenprocumonum
Phenprogramma
Phenylpropylhydroxycumarinum
Ro 1-4849
Roche Brand of Phenprocoumon
S2188_Selleck
U29342
UNII-Q08SIO485D
Worwag Brand of Phenprocoumon
fenprocumon
3
AcenocoumarolPhase 427152-72-79052, 54676537
Synonyms:
152-72-7
2-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-4h-chromen-4-one
2-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]chromen-4-one
3-(alpha-(4'-Nitrophenyl)-beta-acetylethyl)-4-hydroxycoumarin
3-(alpha-(P-Nitrophenol)-beta-acetylethyl)-4-hydroxycoumarin
3-(alpha-(p-Nitrophenol)-beta-acetylethyl)-4-hydroxycoumarin
3-(alpha-Acetonyl-4-nitrobenzyl)-4-hydroxycoumarin
3-(alpha-Acetonyl-P-nitrobenzyl)-4-hydroxycoumarin
3-(alpha-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin
3-(alpha-Acetonyl-para-nitrobenzyl)-4-hydroxy-coumarin
3-(alpha-P-Nitrophenyl-beta-acetylethyl)-4-hydroxycoumarin
3-(alpha-p-Nitrophenyl-beta-acetylethyl)-4-hydroxycoumarin
4-Hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
70897-81-3
AB-014/25000129
AB00513804
AC1L1S7P
AC1Q1Z5F
ACENOCOUMAROL
AR-1E2350
Acenocoumarin
Acenocoumarol (INN)
Acenocoumarol Alliance Brand
Acenocoumarol Ciba-Geigy Brand
Acenocoumarol Novartis Brand
Acenocoumarol [INN]
Acenocoumarolum
Acenocoumarolum [INN-Latin]
Acenocoumarolum [INN-latin]
Acenocoumarolum [inn-latin]
Acenocumarol
Acenocumarolo
Acenocumarolo [DCIT]
Acenocumarolum
Acenokumarin
Acenokumarin [Czech]
Alliance Brand of Acenocoumarol
Ascumar
BPBio1_000110
BRD-A65051990-001-03-8
BSPBio_000100
C19H15NO6
CHEBI:53766
CHEMBL145253
CHEMBL397420
CID9052
 
Ciba Geigy Brand of Acenocoumarol
Ciba-Geigy Brand of Acenocoumarol
D000074
D07064
DB01418
EINECS 205-807-3
G 23350
G-23,350
G-23350
G23350
HMS1568E22
HSDB 3201
Jsp002948
LS-55093
MLS000539171
MLS001074461
Mini Sintrom
Mini-sintrom
Mini-sintrom (TN)
Minisintrom
MolPort-002-798-798
NCGC00179658-01
Neositron
Nicoumalone
Nicumalon
Nitrophenylacetylethyl-4-hydroxycoumarine
Nitrovarfarian
Nitrowarfarin
Novartis Brand of Acenocoumarol
Prestwick0_000110
Prestwick1_000110
Prestwick2_000110
Prestwick3_000110
Prestwick_773
SMR000162652
SPBio_002039
Sincoumar
Sinkumar
Sinthrom
Sinthrome
Sintrom
Sintroma
Syncoumar
Syncumar
Synthrom
Syntrom
UNII-I6WP63U32H
Zotil
4
TiclopidinePhase 343555142-85-35472
Synonyms:
5-((2-Chlorophenyl)methyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine
5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine
55142-85-3
AC-15204
AC1L1KFB
BIDD:PXR0169
BPBio1_000191
BRD-K00603606-003-03-4
BRN 1216802
BSPBio_000173
C07140
C14H14ClNS
CAS-53885-35-1
CHEBI:9588
CHEMBL833
CID5472
D08594
DB00208
EINECS 259-498-5
HMS2089I18
L001108
LS-152434
MLS001201825
MolPort-002-507-849
 
NCGC00016872-01
NCGC00016872-02
NCGC00024361-04
PCR 5332
Prestwick0_000047
Prestwick1_000047
Prestwick2_000047
Prestwick3_000047
SMR000641861
SPBio_002094
STK589340
STOCK5S-54105
Ticlid
Ticlopidin-Puren
Ticlopidin-Puren (TN)
Ticlopidina
Ticlopidina [INN-Spanish]
Ticlopidine (INN)
Ticlopidine HCL
Ticlopidine Hydrochloride
Ticlopidine [INN:BAN]
Ticlopidinum
Ticlopidinum [INN-Latin]
UNII-OM90ZUW7M1
UNM-0000345023
ZINC19594599
ticlopidine
5
ClopidogrelPhase 3733120202-66-6, 113665-84-260606
Synonyms:
( )-(S)-Clopidogrel
(+)-(S)-Clopidogrel
(+)-Clopidogrel
(S)-Clopidogrel
(S)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
113665-84-2
AC-19024
AC1L1TKZ
AC1Q41I9
BIDD:GT0284
BRD-K27721098-065-02-9
BSPBio_003211
C16H16ClNO2S
CGE
CHEBI:37941
CHEMBL1771
CID60606
CLOPIDOGREL SULFATE
CPD000550475
Clopidogrel
Clopidogrel (INN)
Clopidogrel (TN)
Clopidogrel [BAN:INN]
Clopidogrel [Ban:Inn]
Clopidogrel [INN:BAN]
Clopidogrel bisulfate
Clopidogrel bisulphate
Clopidogrel sulfate
Clopidogrelum
D07729
DB00758
DivK1c_000787
HMS2090O21
HMS502H09
HSDB 7430
IDI1_000787
 
Isocover
KBio1_000787
KBio2_000545
KBio2_003113
KBio2_005681
KBio3_002431
KBioGR_000689
KBioSS_000545
LS-172232
MLS001165708
MLS001195633
MLS001304711
Methyl (+)-(S)-alpha-(o-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4H)-acetate
MolPort-002-885-817
MolPort-003-845-991
NCGC00163329-02
NINDS_000787
Plavix
Plavix (TN)
SAM002589956
SMR000550475
SPBio_000463
SR 25990
STK580572
STOCK5S-27782
Spectrum2_000512
Spectrum3_001606
Spectrum4_000175
Spectrum_000105
TL8000400
UNII-A74586SNO7
Zyllt
clopidogrel
clopidogrel, (+)(S)-isomer
methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate
methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
nchem.651-comp8
6Prasugrel hydrochloridePhase 3137389574-19-0

Interventional clinical trials:

idNameStatusNCT IDPhase
1EUropean Pharmacogenetics of AntiCoagulant Therapy - WarfarinCompletedNCT01119300Phase 4
2EUropean Pharmacogenetics of AntiCoagulant Therapy - AcenocoumarolCompletedNCT01119261Phase 4
3EUropean Pharmacogenetics of AntiCoagulant Therapy - PhenprocoumonCompletedNCT01119274Phase 4
4Prasugrel Versus High Dose Clopidogrel in Clopidogrel Resistant Patients Undergoing Chronic HemodialysisCompletedNCT01155765Phase 3

Search NIH Clinical Center for Coumarin Resistance


Cochrane evidence based reviews: drug resistance

Genetic Tests for Coumarin Resistance

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Genetic tests related to Coumarin Resistance:

id Genetic test Affiliating Genes
1 Warfarin Response25

Anatomical Context for Coumarin Resistance

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MalaCards organs/tissues related to Coumarin Resistance:

34
Heart, Brain

Animal Models for Coumarin Resistance or affiliated genes

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Publications for Coumarin Resistance

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Articles related to Coumarin Resistance:

idTitleAuthorsYear
1
gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase. (1323022)
1992
2
Coumarin resistance: a diagnostic and therapeutic approach. (910171)
1977
3
Coumarin resistance in a Negro woman. (4123117)
1973

Variations for Coumarin Resistance

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UniProtKB/Swiss-Prot genetic disease variations for Coumarin Resistance:

68 (show all 18)
id Symbol AA change Variation ID SNP ID
1VKORC1p.Val29LeuVAR_021821rs104894539
2VKORC1p.Val45AlaVAR_021822rs104894540
3VKORC1p.Arg58GlyVAR_021823rs104894541
4VKORC1p.Leu128ArgVAR_021825rs104894542
5VKORC1p.Ala26ThrVAR_065785
6VKORC1p.Asp36GlyVAR_065786
7VKORC1p.Asp36TyrVAR_065787rs61742245
8VKORC1p.Ser52TrpVAR_065788
9VKORC1p.Ser56PheVAR_065789
10VKORC1p.Trp59CysVAR_065790
11VKORC1p.Trp59LeuVAR_065791
12VKORC1p.Val66GlyVAR_065792
13VKORC1p.Val66MetVAR_065793rs72547529
14VKORC1p.Gly71AlaVAR_065794
15VKORC1p.Asn77SerVAR_065795
16VKORC1p.Asn77TyrVAR_065796rs755767348
17VKORC1p.Ile123AsnVAR_065797
18VKORC1p.Tyr139HisVAR_065798

Clinvar genetic disease variations for Coumarin Resistance:

5 (show all 13)
id Gene Variation Type Significance SNP ID Assembly Location
1F9F9, ALA-10THRsingle nucleotide variantPathogenic
2F9F9, ALA-10VALundetermined variantPathogenic
3VKORC1NM_024006.5(VKORC1): c.-1639G=single nucleotide variantdrug responsers9923231GRCh37Chr 16, 31107689: 31107689
4CYP2A6NM_000762.5(CYP2A6): c.479T> A (p.Leu160His)single nucleotide variantdrug responsers1801272GRCh37Chr 19, 41354533: 41354533
5CYP2A6*12Adeletiondrug responseGRCh38Chr 19, 40848764: 40881588
6VKORC1NM_024006.5(VKORC1): c.85G> T (p.Val29Leu)single nucleotide variantPathogenicrs104894539GRCh37Chr 16, 31105966: 31105966
7VKORC1NM_024006.5(VKORC1): c.134T> C (p.Val45Ala)single nucleotide variantPathogenicrs104894540GRCh37Chr 16, 31105917: 31105917
8VKORC1NM_024006.5(VKORC1): c.172A> G (p.Arg58Gly)single nucleotide variantPathogenicrs104894541GRCh37Chr 16, 31105879: 31105879
9VKORC1NM_024006.5(VKORC1): c.383T> G (p.Leu128Arg)single nucleotide variantPathogenicrs104894542GRCh37Chr 16, 31102564: 31102564
10VKORC1NM_024006.4(VKORC1): c.-1639G> Asingle nucleotide variantdrug responsers9923231GRCh37Chr 16, 31107689: 31107689
11VKORC1NM_024006.5(VKORC1): c.106G> T (p.Asp36Tyr)single nucleotide variantdrug responsers61742245GRCh37Chr 16, 31105945: 31105945
12VKORC1NM_024006.5(VKORC1): c.-1588dupGduplicationdrug responsers397509427GRCh37Chr 16, 31107638: 31107638
13CYP2C9NM_000771.3(CYP2C9): c.622T> G (p.Leu208Val)single nucleotide variantPathogenicrs72558191GRCh37Chr 10, 96707676: 96707676

Expression for genes affiliated with Coumarin Resistance

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Search GEO for disease gene expression data for Coumarin Resistance.

Pathways for genes affiliated with Coumarin Resistance

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Pathways related to Coumarin Resistance according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
19.5CYP2A6, CYP2C9
29.5CYP2A6, CYP2C9
3
Show member pathways
9.5CYP2A6, CYP2C9
49.5CYP2A6, CYP2C9
5
Show member pathways
9.5CYP2C9, CYP4F2
6
Show member pathways
9.4CYP2A13, CYP2C9
7
Show member pathways
9.3CYP2A13, CYP2A6
8
Show member pathways
9.3CYP2A13, CYP2A6
99.2CYP4F2, F9, VKORC1
10
Show member pathways
8.9CYP2A13, CYP2A6, CYP2C9
11
Show member pathways
8.9CYP2A13, CYP2A6, CYP2C9
12
Show member pathways
8.4CYP2A13, CYP2A6, CYP2C9, CYP4F2
13
Show member pathways
8.4CYP2A13, CYP2A6, CYP2C9, CYP4F2

GO Terms for genes affiliated with Coumarin Resistance

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Cellular components related to Coumarin Resistance according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1organelle membraneGO:00310908.6CYP2A13, CYP2A6, CYP2C9, CYP4F2
2endoplasmic reticulum membraneGO:00057897.2CYP2A13, CYP2A6, CYP2C9, CYP4F2, MCFD2, VKORC1

Biological processes related to Coumarin Resistance according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:001718710.3F9, VKORC1
2exogenous drug catabolic processGO:004273810.0CYP2A6, CYP2C9
3omega-hydroxylase P450 pathwayGO:009726710.0CYP2C9, CYP4F2
4steroid metabolic processGO:00082029.9CYP2A6, CYP2C9
5coumarin metabolic processGO:00098049.9CYP2A13, CYP2A6
6xenobiotic metabolic processGO:00068059.3CYP2A13, CYP2C9
7blood coagulationGO:00075969.2CYP4F2, F9, VKORC1
8drug metabolic processGO:00171449.1CYP2A6, CYP2C9, CYP4F2, VKORC1
9epoxygenase P450 pathwayGO:00193738.8CYP2A13, CYP2A6, CYP2C9, CYP4F2
10oxidation-reduction processGO:00551147.7CYP2A13, CYP2A6, CYP2C9, CYP4F2, VKORC1

Molecular functions related to Coumarin Resistance according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1coumarin 7-hydroxylase activityGO:00083899.9CYP2A13, CYP2A6
2monooxygenase activityGO:00044979.8CYP2C9, CYP4F2
3oxygen bindingGO:00198259.7CYP2A13, CYP2C9
4steroid hydroxylase activityGO:00083958.8CYP2A13, CYP2A6, CYP2C9
5arachidonic acid epoxygenase activityGO:00083928.7CYP2A13, CYP2A6, CYP2C9, CYP4F2
6iron ion bindingGO:00055068.4CYP2A13, CYP2A6, CYP2C9, CYP4F2
7heme bindingGO:00200378.1CYP2A13, CYP2A6, CYP2C9, CYP4F2

Sources for Coumarin Resistance

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
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32KEGG
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