Cramps malady

Wikipedia: Cramps are unpleasant, often painful sensations caused by muscle contraction or over shortening. Common...⁴⁴ more...

MalaCards: Cramps is related to myoclonus-dystonia and phosphoglycerate mutase deficiency. An important gene associated with Cramps is CRAMP1L (Crm, cramped-like (Drosophila)), and among its related pathways are Antigen processing and presentation and Graft-versus-host disease. The compounds nitric oxide and ivig have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle and skeletal muscle, and related mouse phenotypes are growth/size and homeostasis/metabolism.

cramps 7

Diseases related to cramps by text searches and GeneDecks gene sharing:

(show top 50)    (show all 701)

id	Related Disease	Score	Top Affiliating Genes
1	myoclonus-dystonia	29.1	SGCE, TOR1A
2	phosphoglycerate mutase deficiency	29.0	PGAM1, PGAM2
3	glycogen storage disease v	28.0	AMPD1, PYGM, CPT2, PGAM1
4	mitochondrial encephalomyopathy	27.7	PFKM, OPA1, SLC25A20, CPT2
5	hypoparathyroidism	27.6	PIK3C2A, GCM2, INS, CASR, GLA, PTH
6	creatine phosphokinase	27.4	PIK3C2A, MB, GPT, AFP
7	focal dystonia	27.3	SGCE, PARK2, TOR1A
8	neuromuscular disease	27.2	SCN4A, MB, AMPD1, DMD, SMN1
9	bartter disease	27.1	REN, CASR, NPPA
10	gastroenteritis	27.0	REN, LACTB, IL10, IL1B, IFNA1, ALB
11	dumping syndrome	26.9	INS, PYY, SST, NPPA
12	myoclonus	25.8	SGCE, PARK2, INS, SNCA, TOR1A, GBA
13	back pain	25.6	INS, IL1A, IL1B, MB, TNF
14	fabry disease	25.6	IL10, IL1A, IL1B, GLA, TNF, NPY
15	irritable bowel syndrome	25.4	LEP, IL10, IFNG, TNF, PYY, SST
16	short bowel syndrome	24.9	LEP, IL1B, ALB, GH1, TNF, PYY
17	cholera	24.3	PIK3C2A, INS, IL10, IL12B, IL1A, IL1B
18	muscular dystrophy	24.2	PIK3C2A, SGCE, PARK2, SCN4A, INS, MB
19	lateral sclerosis	23.6	PARK2, UCP3, MB, ALB, GH1, TNF
20	myopathy	22.1	PIK3C2A, PARK2, SCN4A, LEP, INS, IL1A
21	diarrhea	21.8	REN, LACTB, INS, IL10, IL1B, GPT
22	nephropathy	21.6	REN, PARK2, LEP, UCP3, INS, IL10
23	twinning	21.6	REN, SGCE, LEP, INS, IL10, IL12B
24	familial dystonia	13.8	SGCE, TOR1A, PRKRA
25	hypoparathyroidism, autosomal dominant	13.8	GCM2, CASR, PTH
26	hypoparathyroidism familial isolated	13.6	GCM2, PTH
27	myoglobinuria recurrent	13.6	PYGM, DMD, CPT2
28	wermer syndrome	13.5	CASR, PYGM, PTH, SST
29	adult glioblastoma multiforme	13.4	HLA-B, HLA-C, SLC2A1
30	lactic acidosis	13.4	PIK3C2A, MB, PYGM, PFKM
31	hyperphosphatemia	13.4	GCM2, ALB, CASR, PTH
32	constrictive pericarditis	13.4	REN, ALB, ADA
33	protein s deficiency	13.4	DMD, SMN1, SLC25A20, CPT2
34	hypocalcemia	13.3	PIK3C2A, GCM2, ALB, CASR, PTH
35	esophageal varix	13.3	ALB, SST, AFP
36	leptin deficiency	13.3	LEP, GH1, NPY
37	pericardial effusion	13.3	PIK3C2A, ALB, ADA
38	anuria	13.3	REN, MB, ALB
39	acute kidney tubular necrosis	13.3	PIK3C2A, MB, ALB, NPPA
40	hematuria	13.3	PIK3C2A, INS, MB, COL4A1
41	paraneoplastic syndromes	13.2	IMMT, ALB, NPPA, AFP
42	bacterial meningitis	13.2	PIK3C2A, LACTB, IL1B, ADA
43	necrotizing fasciitis	13.2	PIK3C2A, INS, GPT
44	silent myocardial infarction	13.2	PIK3C2A, INS
45	twin-to-twin transfusion syndrome	13.2	REN, ALB, NPPA, AFP
46	twin twin transfusion syndrome	13.2	REN, ALB, NPPA, AFP
47	hypophosphatemia	13.2	ALB, CASR, GH1, PTH
48	congestive heart failure	13.2	PIK3C2A, REN, AMPD1, NPPA, NPY, CPT2
49	galactosemia	13.2	PIK3C2A, GPT, ALB, AFP
50	pituitary apoplexy	13.2	INS, GH1, NPPA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cramps:

²²

MGI Mouse Phenotypes related to cramps:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	, SMN1, PLIN1, COL4A1, PRKRA, OPA1
2	homeostasis/metabolism phenotype	MP:0005376	INF	GBA, SST, , SMN1, PLIN1, COL4A1
3	cardiovascular system phenotype	MP:0005385	INF	PTH, DMD, , SMN1, COL4A1, PFKM
4	endocrine/exocrine gland phenotype	MP:0005379	8.9	OPA1, PFKM, DMD, PTH, IFNG, GCM2
5	liver/biliary system phenotype	MP:0005370	8.5	GBA, ADA, PLIN1, DMD, GH1, GLA
6	adipose tissue phenotype	MP:0005375	8.1	PYY, DMD, PLIN1, OPA1, NPY, TNF
7	muscle phenotype	MP:0005369	5.8	DMD, SMN1, PLIN1, COL4A1, PHKA1, PFKM
8	renal/urinary system phenotype	MP:0005367	INF	ADRA2B, NPPA, COL4A1, , DMD, HMBS
9	mortality/aging	MP:0010768	INF	TOR1A, PFKM, COL4A1, SMN1, , PRKRA
10	cellular phenotype	MP:0005384	INF	TNF, DMD, , SMN1, COL4A1, TOR1A
11	nervous system phenotype	MP:0003631	INF	SMN1, TOR1A, NPY, SLC2A1, GBA,
12	skeleton phenotype	MP:0005390	INF	, SMN1, PRKRA, ADA, GBA, DMD
13	reproductive system phenotype	MP:0005389	INF	, SMN1, PRKRA, OPA1, ADRA2B, AFP
14	immune system phenotype	MP:0005387	INF	PTH, DMD, PFKM, GBA, TNF, HLA-C
15	hematopoietic system phenotype	MP:0005397	INF	ADA, COL4A1, DMD, PTH, HLA-C, CASR
16	respiratory system phenotype	MP:0005388	INF	GBA, ADRA2B, ADA, PRKRA, SMN1, DMD
17	digestive/alimentary phenotype	MP:0005381	INF	SST, , SMN1, CRAMP1L, NPY, DMD
18	behavior/neurological phenotype	MP:0005386	INF	DMD, SST, , SMN1, PLIN1, COL4A1

Articles related to cramps:

(show all 22)

id	Title	Authors	Year	Affiliating Genes
1	Paroxysmal exercise-induced dyskinesia, writer's cramp, migraine with aura and absence epilepsy in twin brothers with a novel SLC2A1 missense mutation. (20621801)	Urbizu A.... Macaya A.	2010	SLC2A1
2	Pediatric writer's cramp in myoclonus-dystonia: maternal imprinting hides positive family history. (18571946)	Gerrits M.C.... Tijssen M.A.	2009	SGCE
3	Screening for dystonia genes DYT1, 11 and 16 in patie nts with writer's cramp. (19441135)	Ritz K.... Tijssen M.A.	2009	SGCE, TOR1A, PRKRA
4	Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study. (19141993)	Hung C.Y.... Peng S.J.	2009	LEP
5	Hereditary angiopathy with nephropathy, aneurysms and muscle cramps (HANAC): a new basement membrane-disease associated with mutations of the COL4A1 gene (19238787)	Ronco P.... Plaisier E.	2008	COL4A1
6	Unusual familial presentation of epsilon-sarcoglycan gene mutation with falls and writer's cramp. (18702114)	Koukouni V.... Quinn N.P.	2008	SGCE
7	COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. (18160688)	Plaisier E.... Ronco P.	2007	COL4A1
8	Exercise-induced cramp, myoglobinuria, and tubular aggregates in phosphoglycerate mutase deficiency. (16881065)	Oh S.J.... DiMauro S.	2006	PGAM1
9	Later-onset Fabry disease: an adult variant presenting with the cramp-fasciculation syndrome. (16533976)	Nance C.S.... Desnick R.J.	2006	GLA
10	The role of serum zinc and other factors on the prevalence of muscle cramps in non-alcoholic cirrhotic patients. (15220689)	Baskol M.... Yucesoy M.	2004	ALB, GPT
11	Writer's cramp in an Australian pedigree with DYT1 dystonia. (15177405)	van den Bos M.... Thyagarajan D.	2004	TOR1A
12	Pathologic quiz case: a man with exertion-induced cramps and myoglobinuria. McArdle disease (glycogenosis type V or myophosphorylase deficiency). (12951997)	Getachew E.... Prayson R.A.	2003	PYGM
13	Autosomal recessive rolandic epilepsy with paroxysmal exercise-induced dystonia and writer's cramp: delineation of the syndrome and gene mapping to chromosome 16p12-11.2. (10072049)	Guerrini R.... Casari G.	1999	EPRPDC
14	Phenotypic expression of the DYT1 mutation: a family with writer's cramp of juvenile onset. (9667600)	Gasser T.... Ludolph A.C.	1998	TOR1A
15	Cramps and minimal EMG abnormalities as preclinical manifestations of spinal muscular atrophy patients with homozygous deletions of the SMN gene. (9153488)	Bussaglia E.... Baiget M.	1997	SMN1
16	Cirrhosis and muscle cramps: evidence of a causal rel ationship. (8591851)	Angeli P.... Gatta A.	1996	ALB
17	Muscle cramps and elevated serum creatine phosphokinase levels induced by beta-adrenoceptor blockers. (7621844)	Imai Y.... Abe K.	1995	PIK3C2A
18	Muscle cramping in phase I clinical trials of tirapaz amine (SR 4233) with and without radiation. (8195037)	Doherty N.... Roemeling R.V.	1994	PIK3C2A
19	Efficacy of high-velocity low-amplitude manipulative technique in subjects with low-back pain during menstrual cramping. (8432669)	Boesler D.... Kilmore M.A.	1993	MB
20	Dystrophinopathy in two young boys with exercise-induced cramps and myoglobinuria. (8223790)	Minetti C.... Bonilla E.	1993	DMD
21	Mosaic expression of dystrophin in carriers of Becker 's muscular dystrophy and the X-linked syndrome of myalgia and cramps. (1522852)	Minetti C.... Bonilla E.	1992	DMD
22	Familial X-linked myalgia and cramps: a nonprogressive myopathy associated with a deletion in the dystrophin gene. (2677830)	Gospe S.M.... Fischbeck K.H.	1989	DMD

Genes related to cramps according to GeneCards:

(show top 50)    (show all 68)

id	Symbol	Description	Score	GeneCards Section Context
1	CRAMP1L	Crm, cramped-like (Drosophila)	11.1	Functions, Aliases & Descriptions, Domains & Families, Gene (show all 7 sections) Databases, Transcripts, Orthologs
2	HN1L	hematological and neurological expressed 1-like	11.1	Aliases & Descriptions, Databases
3	EPRPDC	Epilepsy, rolandic, with paroxysmal exercise-induced dystonia and writer's cramp	11.1	Aliases & Descriptions, Publications
4	SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	11.0
5	GLA	galactosidase, alpha	11.0	Publications
6	COL4A1	collagen, type IV, alpha 1	11.0	Publications
7	ENSG00000261732		11.0	Paralogs
8	ENSG00000231128		11.0
9	FRA1I	fragile site, aphidicolin type, common, fra(1)(q44)	11.0
10	PIR39921		11.0
11	ENSG00000203547		11.0
12	PIR36118		11.0
13	PGAM2	phosphoglycerate mutase 2 (muscle)	11.0
14	GCM2	glial cells missing homolog 2 (Drosophila)	11.0
15	PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	11.0	Publications
16	PGAM1	phosphoglycerate mutase 1 (brain)	11.0	Publications
17	TOR1A	torsin family 1, member A (torsin A)	11.0	Publications
18	SGCE	sarcoglycan, epsilon	11.0	Publications
19	PYGM	phosphorylase, glycogen, muscle	11.0	Publications
20	IL28B	interleukin 28B (interferon, lambda 3)	11.0	Publications
21	NEK9	NIMA (never in mitosis gene a)- related kinase 9	11.0	Pathways & Interactions
22	SLC25A20	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	11.0	Pathways & Interactions
23	ADRA2B	adrenoceptor alpha 2B	11.0	Publications
24	HMBS	hydroxymethylbilane synthase	11.0	Publications
25	PLIN1	perilipin 1	11.0	Publications
26	AMPD1	adenosine monophosphate deaminase 1	11.0
27	PHKA1	phosphorylase kinase, alpha 1 (muscle)	11.0
28	IMMT	inner membrane protein, mitochondrial	11.0	Publications
29	HRH4	histamine receptor H4	11.0	Publications
30	PFKM	phosphofructokinase, muscle	11.0
31	KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	11.0	Publications
32	LIPE	lipase, hormone-sensitive	11.0	Publications
33	CPT2	carnitine palmitoyltransferase 2	11.0
34	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	11.0	Publications
35	SNCAIP	synuclein, alpha interacting protein	11.0
36	PTH	parathyroid hormone	11.0
37	PYY	peptide YY	11.0	Publications
38	SI	sucrase-isomaltase (alpha-glucosidase)	11.0
39	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
40	OPA1	optic atrophy 1 (autosomal dominant)	11.0
41	GBA	glucosidase, beta, acid	11.0
42	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
43	LACTB	lactamase, beta	11.0	Publications
44	CASR	calcium-sensing receptor	11.0
45	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	11.0	Publications
46	AFP	alpha-fetoprotein	11.0	Publications
47	ADA	adenosine deaminase	11.0	Publications
48	NPY	neuropeptide Y	11.0	Publications
49	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
50	MB	myoglobin	11.0	Publications

Pathways related to cramps according to GeneDecks:

(show all 25)

id	Pathway	Score	Top Affiliating Genes
1	Antigen processing and presentation20	10.4	HLA-C, KIR2DL3
2	Graft-versus-host disease20	10.0	HLA-C, HLA-B, IL1A, KIR2DL3
3	AMPK Enzyme Complex Pathway36	9.6	ADRA2B, CPT2, SLC2A1, PFKM, INS, LEP
4	Jak-STAT signaling pathway20	9.2	GH1, IFNA1, IL28B, IL12B, IL10, LEP
5	Autoimmune thyroid disease20	9.1	IL10, IFNA1, HLA-B, HLA-C
6	IL-10 Pathway36	9.1	IL10, IL1A, IL1B, TNF
7	Pertussis20	9.0	TNF, IL1B, IL1A, IL12B, IL10
8	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.0	PTH, TNF, IFNG, IL1B, IL1A
9	MSP-RON Signaling36	9.0	TNF, IFNG, IL1B, IL12B
10	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.0	PTH, TNF, IFNG, IL1B, IL1A
11	THC Differentiation Pathway36	8.9	TNF, IFNG, IL12B, IL10
12	Th1 Differentiation37	8.9	TNF, IFNG, IL12B, IL10
13	Natural killer cell mediated cytotoxicity20	8.7	KIR2DL3, IFNA1, IFNG, HLA-B, HLA-C, TNF
14	HMGB1 Pathway36	8.7	IL1A, IL1B, IFNG, TNF
15	African trypanosomiasis20	8.7	TNF, IFNG, IL1B, IL12B, IL10
16	Amoebiasis20	8.6	COL4A1, TNF, IFNG, IL1B, IL12B, IL10
17	Allograft rejection20	8.6	TNF, HLA-C, HLA-B, IFNG, IL12B, IL10
18	Leishmaniasis20	8.5	TNF, IFNG, IL1B, IL1A, IL12B, IL10
19	Influenza A20	8.4	TNF, IFNG, IFNA1, IL1B, IL1A, IL12B
20	Chagas disease (American trypanosomiasis)20	8.4	TNF, IFNG, IL1B, IL12B, IL10
21	Cytokine Network36	8.2	TNF, IFNG, IFNA1, IL1B, IL1A, IL12B
22	Malaria20	8.2	TNF, IFNG, IL1B, IL10
23	Type I diabetes mellitus20	8.2	INS, TNF, HLA-C, HLA-B, IFNG, IL1B
24	Tuberculosis20	8.1	TNF, IFNG, IFNA1, IL1B, IL1A, IL12B
25	Cytokine-cytokine receptor interaction20	7.6	TNF, GH1, IFNG, IFNA1, IL28B, IL1B

Compounds related to cramps according to GeneDecks:

(show top 50)    (show all 223)

id	Compound	Score	Top Affiliating Genes
1	nitric oxide32 9 18 9	INF	GBA, NPY, NPPA, , DMD, PTH
2	ivig32	10.7	PIK3C2A
3	aspartate32	9.9	GLA, SI, GH1, MB, PIK3C2A, LIPE
4	pyruvate32	9.8	PYGM, GBA, SI, CPT2, PIK3C2A, UCP3
5	intralipid32	9.8	LEP, UCP3, PYY, SST, GH1
6	propranolol32 34 9 18 9	13.7	AMPD1, ADA, LIPE, REN, PYY, NPPA
7	carnitine32	9.7	INS, CPT2, SLC25A20, PFKM, AMPD1, MB
8	acipimox32	9.5	LEP, SST, GH1, LIPE, UCP3, INS
9	calcitriol32 42 9 18 9	13.4	PTH, GH1, SLC2A1, CASR, ALB, REN
10	fatty acid32	9.2	PFKM, SLC25A20, CPT2, SI, PLIN1, PYY
11	corticosterone32 18	10.2	IL1A, GPT, GH1, IL1B, NPY
12	polyinosinic-polycytidylic acid32	9.0	HLA-B, IFNA1, IL10, IL12B, IFNG
13	isoproterenol32 9 9	10.9	GH1, IL1A, LIPE, PYY, PTH, DMD
14	clonidine32 9 9	10.8	PYY, REN, ADRA2B, NPY, LEP, GH1
15	sodium nitroprusside32	8.8	PIK3C2A, REN, IL12B, LEP, SST, SLC2A1
16	acth32	8.6	CASR, NPY, SST, PYY, IL1B, IL1A
17	ibmx32	8.6	GH1, ADA, SLC2A1, NPPA, PLIN1, SST
18	epinephrine32 9 18 9	11.5	NPPA, ADRA2B, ADA, NPY, MB, IL1A
19	glycerol32 9 18 9	11.5	MB, INS, GH1, LIPE, DMD, ADA
20	ribavirin32 34 9 9	11.5	AFP, ADA, IFNG, GPT, IFNA1, IL28B
21	forskolin32 42 9 9	11.3	ADA, REN, SI, SLC2A1, NPY, NPPA
22	imiquimod32 42 9 9	11.3	IFNG, TNF, IL1A, IL12B, IL10, IFNA1
23	il-1232	8.2	IFNG, IL10, IL12B, IFNA1, IL1B, TNF
24	2,5-oligoadenylate32	8.1	IL10, IFNG, GPT, TNF, HLA-B, ADA
25	neopterin32	7.9	IL10, IL1A, IL1B, TNF, ADA, IFNA1
26	creatinine32	7.8	NPY, ADA, PFKM, DMD, PTH, PYGM
27	thyroxine32 18	8.5	MB, AFP, NPY, SST, PTH, GH1
28	hydrocortisone32 9 9	9.5	REN, SI, SST, TNF, GH1, INS
29	methotrexate32 34 42 9 9	11.4	IL10, IL1B, GPT, AMPD1, ALB, GH1
30	prednisolone32 9 9	9.1	ALB, IFNG, PIK3C2A, IFNA1, GPT, IL10
31	cyclosporin a32 42	7.6	ADA, DMD, NPPA, TNF, HLA-B, PIK3C2A
32	dexamethasone32 42 34 9 9	9.9	IL1B, SLC2A1, SI, LEP, ADA, AFP
33	dopamine32 9 18 9	INF	SST, REN, PARK2, MB, GH1, HMBS
34	cholesterol32 9 18 9	INF	PYY, REN, LIPE, LEP, PIK3C2A, HLA-B
35	alanine32	INF	DMD, SLC2A1, NPY, PFKM, , SNCAIP
36	norepinephrine32 9 18 9	INF	LEP, PIK3C2A, REN, LIPE, UCP3, INS
37	glutamate32	INF	CPT2, SLC2A1, TOR1A, , SST, CASR
38	adenylate32	INF	, NPY, CPT2, ADA, GBA, HLA-B
39	glycogen32 18	INF	PIK3C2A, PFKM, SLC2A1, CPT2, PGAM2, AFP
40	glucose32	INF	SLC25A20, SLC2A1, DMD, PARK2, , AMPD1
41	lactate32	INF	ADA, SI, CPT2, SLC2A1, NPY, PFKM
42	pge232	INF	REN, , SST, CASR, MB, IL1A
43	tacrolimus32 34 9 9	INF	TNF, REN, INS, IL10, GPT, IFNA1
44	polyethylene glycol32	INF	, AFP, NPPA, MB
45	lipid32	INF	PIK3C2A, IMMT, SI, AFP, GBA, IL12B
46	atp32	INF	SCN4A, PIK3C2A, SLC2A1, IMMT, CPT2, ADA
47	serine32	INF	LIPE, GH1, SLC2A1, PARK2, INS, HLA-B
48	arginine32	INF	PYY, ADA, SI, SLC25A20, NPY, SMN1
49	vegf32	INF	REN, PARK2, PIK3C2A, NPPA, UCP3, SLC2A1
50	testosterone32 9 18 9	INF	PTH, , AFP, SST, PIK3C2A, HLA-B

Cellular components related to cramps according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	5.0	REN, GH1, TNF, PYY, PTH, SST
2	extracellular region	GO:005576	INF	PYY, PTH, SST, , COL4A1, NPPA

Biological processes related to cramps according to GeneDecks:

(show all 22)

id	Name	GO ID	Score	Top Affiliating Genes
1	carbohydrate metabolic process	GO:005975	9.9	GBA, SI, PGAM2, PGAM1, SLC2A1, PFKM
2	response to insulin stimulus	GO:032868	9.5	LEP, UCP3, IL10, NPPA, SI
3	positive regulation of vitamin D biosynthetic process	GO:060557	9.4	IFNG, TNF
4	negative regulation of lipid catabolic process	GO:050995	9.4	INS, IL1B, TNF
5	positive regulation of mitosis	GO:045840	9.4	TNF, IL1B, IL1A, INS
6	glucose metabolic process	GO:006006	9.4	PGAM2, PGAM1, PFKM, PHKA1, PYGM, TNF
7	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.3	IL1B, IFNG, TNF
8	negative regulation of interleukin-6 production	GO:032715	9.3	GBA, TNF, IL10
9	positive regulation of osteoclast differentiation	GO:045672	9.3	TNF, IFNG, IL12B
10	positive regulation of chemokine biosynthetic process	GO:045080	9.2	IL1B, IFNG, TNF
11	positive regulation of cytokine secretion	GO:050715	9.2	TNF, IL1A, IL10, INS
12	positive regulation of NF-kappaB import into nucleus	GO:042346	9.2	IL12B, IL1B, TNF
13	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.2	IL1B, IFNG, TNF
14	response to glucocorticoid stimulus	GO:051384	9.1	SI, TNF, IL1B, IL10, UCP3
15	negative regulation of growth of symbiont in host	GO:044130	9.0	TNF, IFNG, IL12B, IL10
16	positive regulation of nitric oxide biosynthetic process	GO:045429	8.9	TNF, IFNG, IL1B, INS
17	cell-cell signaling	GO:007267	8.9	ADRA2B, SST, PTH, PYY, IL1B, IL10
18	response to hypoxia	GO:001666	8.9	ADA, PYGM, TNF, HMBS, MB, IL1B
19	regulation of insulin secretion	GO:050796	8.6	SLC2A1, TNF, IFNG, IL1B, INS, LEP
20	response to drug	GO:042493	INF	, SST, TNF, HMBS, IFNG, IL10
21	glycolysis	GO:006096	INF	PGAM2, PGAM1, PFKM,
22	small molecule metabolic process	GO:044281	INF	PIK3C2A, PFKM, SLC2A1, SLC25A20, CPT2, PGAM1

Molecular functions related to cramps according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide hormone receptor binding	GO:051428	9.8	LEP, PTH, NPPA
2	hormone activity	GO:005179	8.8	LEP, NPPA, SST, PTH, PYY, GH1
3	cytokine activity	GO:005125	7.8	TNF, IFNG, IL28B, IL1B, IL1A, IL12B