Aliases & Classifications for Cranial Nerve Palsy

MalaCards integrated aliases for Cranial Nerve Palsy:

Name: Cranial Nerve Palsy 12 14
Cranial Nerve Paralysis 12 28
Cranial Nerve Diseases 41 69
Cranial Nerve Palsies 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3817
MeSH 41 D003389
NCIt 46 C26941
SNOMED-CT 64 73013002
ICD10 32 G53 G52.8
UMLS 69 C0151311

Summaries for Cranial Nerve Palsy

MalaCards based summary : Cranial Nerve Palsy, also known as cranial nerve paralysis, is related to fourth cranial nerve palsy and sphenoid sinusitis, and has symptoms including neurologic symptoms, circumoral paresthesia and ophthalmoplegia. An important gene associated with Cranial Nerve Palsy is APC (APC, WNT Signaling Pathway Regulator), and among its related pathways/superpathways is G12-G13 in Cellular Signaling. The drugs Pyrimethamine and Sulfadiazine have been mentioned in the context of this disorder. Affiliated tissues include b cells, pituitary and prostate.

Related Diseases for Cranial Nerve Palsy

Diseases in the Cranial Nerve Palsy family:

Multiple Cranial Nerve Palsy

Diseases related to Cranial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 fourth cranial nerve palsy 33.8 APC CHN1
2 sphenoid sinusitis 29.8 RHNO1 SLC25A16
3 multiple cranial nerve palsy 12.5
4 cranial nerve disease 12.4
5 fourth cranial nerve palsy, familial congenital 12.4
6 third cranial nerve disease 12.1
7 oculomotor nerve paralysis 11.2
8 bell's palsy 11.2
9 brown-vialetto-van laere syndrome 1 11.2
10 abducens nerve disease 11.2
11 congenital oculomotor nerve palsy 11.2
12 congenital abducens nerve palsy 11.2
13 congenital trochlear nerve palsy 11.2
14 behcet syndrome 11.0
15 cowden syndrome 1 11.0
16 paraganglioma and gastric stromal sarcoma 11.0
17 diabetic neuropathy 11.0
18 eastern equine encephalitis 11.0
19 tolosa-hunt syndrome 11.0
20 glomus vagale tumor 11.0
21 optic nerve disease 10.8
22 aneurysm 10.3
23 meningitis 10.2
24 lymphoma 10.2
25 carotid artery dissection 10.2
26 nasopharyngitis 10.2
27 pituitary apoplexy 10.2
28 cerebritis 10.2
29 nasopharyngeal carcinoma 10.1
30 episodic pain syndrome, familial, 1 10.1
31 intracranial hypotension 10.1
32 neuropathy 10.1
33 intracranial sinus thrombosis 10.1 NT5C3A RHNO1
34 systemic lupus erythematosus 10.1
35 arachnoiditis 10.1
36 herpes zoster 10.1
37 lupus erythematosus 10.1
38 arachnoid cysts 10.1
39 cavernous sinus thrombosis 10.0 NT5C3A RHNO1
40 skull base neoplasm 10.0 NT5C3A SLC25A16
41 strabismus 10.0
42 ataxia and polyneuropathy, adult-onset 10.0
43 leukemia 10.0
44 sinusitis 10.0
45 chikungunya 10.0
46 lemierre's syndrome 10.0
47 prostatitis 10.0
48 retinitis 10.0
49 herpes zoster ophthalmicus 10.0
50 spontaneous intracranial hypotension 10.0

Comorbidity relations with Cranial Nerve Palsy via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Cranial Nerve Palsy:



Diseases related to Cranial Nerve Palsy

Symptoms & Phenotypes for Cranial Nerve Palsy

UMLS symptoms related to Cranial Nerve Palsy:


neurologic symptoms, circumoral paresthesia, ophthalmoplegia

Drugs & Therapeutics for Cranial Nerve Palsy

Drugs for Cranial Nerve Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
2
Sulfadiazine Approved, Investigational, Vet_approved Phase 4 68-35-9 5215
3
Sulfamethoxazole Approved Phase 4 723-46-6 5329
4
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
6
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 58-05-9 143 6006
7 Anti-Infective Agents Phase 4,Phase 2,Phase 3
8 Antimalarials Phase 4
9 Antiparasitic Agents Phase 4
10 Antiprotozoal Agents Phase 4
11 Folic Acid Antagonists Phase 4
12 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
13 Vitamin B Complex Phase 4,Phase 2,Phase 3
14 Folate Nutraceutical Phase 4,Phase 2,Phase 3
15 Vitamin B9 Nutraceutical Phase 4,Phase 2,Phase 3
16
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
17
Cytarabine Approved, Investigational Phase 2, Phase 3 147-94-4 6253
18
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
19
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
20
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
21
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
22
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
23
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
24
Rasburicase Approved, Investigational Phase 2, Phase 3 134774-45-1
25
rituximab Approved Phase 2, Phase 3 174722-31-7 10201696
26
Vincristine Approved, Investigational Phase 2, Phase 3 2068-78-2, 57-22-7 5978
27
Doxil Approved June 1999 Phase 2, Phase 3 31703
28 Adjuvants, Immunologic Phase 2, Phase 3
29 Alkylating Agents Phase 2, Phase 3
30 Anti-Bacterial Agents Phase 2, Phase 3
31 Antibiotics, Antitubercular Phase 2, Phase 3
32 Antidotes Phase 2, Phase 3
33 Anti-Inflammatory Agents Phase 2, Phase 3
34 Antimetabolites Phase 2, Phase 3
35 Antimetabolites, Antineoplastic Phase 2, Phase 3
36 Antineoplastic Agents, Hormonal Phase 2, Phase 3
37 Antirheumatic Agents Phase 2, Phase 3
38 Antiviral Agents Phase 2, Phase 3
39 Etoposide phosphate Phase 2, Phase 3
40 glucocorticoids Phase 2, Phase 3
41 Hematinics Phase 2, Phase 3
42 Hormone Antagonists Phase 2, Phase 3
43 Hormones Phase 2, Phase 3
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
45 Immunosuppressive Agents Phase 2, Phase 3
46 Micronutrients Phase 2, Phase 3
47 Protective Agents Phase 2, Phase 3
48 Topoisomerase Inhibitors Phase 2, Phase 3
49 Trace Elements Phase 2, Phase 3
50 Vitamins Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
2 EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis Completed NCT00190398 Phase 3
3 Mature B-Cell Lymphoma And Leukemia Study III Recruiting NCT01046825 Phase 2, Phase 3 COPAD;COP, COPD M3, CYM;COP, COPADM8, CYVE
4 " Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke " Not yet recruiting NCT02841098 Phase 3 Optimal medical therapy alone
5 Treatment for Advanced B-Cell Lymphoma Recruiting NCT01859819 Phase 2 Rituximab;IT Cytarabine
6 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
7 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070
8 Cranial Nerves Tractography Recruiting NCT02978911
9 Microembolisation After Carotid Revascularisation Recruiting NCT03303430
10 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541

Search NIH Clinical Center for Cranial Nerve Palsy

Cochrane evidence based reviews: cranial nerve diseases

Genetic Tests for Cranial Nerve Palsy

Genetic tests related to Cranial Nerve Palsy:

# Genetic test Affiliating Genes
1 Cranial Nerve Paralysis 28

Anatomical Context for Cranial Nerve Palsy

MalaCards organs/tissues related to Cranial Nerve Palsy:

38
B Cells, Pituitary, Prostate, Brain, T Cells, Myeloid, Tongue

Publications for Cranial Nerve Palsy

Articles related to Cranial Nerve Palsy:

(show top 50) (show all 289)
# Title Authors Year
1
Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. ( 29102606 )
2018
2
Multiple cranial nerve palsies secondary to a recurrence of Hansen's disease. ( 29330278 )
2018
3
Chronic myeloid leukemia presenting as multiple cranial nerve palsy. ( 28960704 )
2017
4
Third cranial nerve palsy and Chikungunya virus infection. ( 29271691 )
2017
5
Third cranial nerve palsy: an unusual manifestation of Mycoplasma pneumoniae. ( 29072872 )
2017
6
Third Cranial Nerve Palsy after a Chikungunya Virus Infection. ( 29135313 )
2017
7
RUNX1-RUNX1T1-positive acute myeloid leukaemia presenting as bilateral proptosis and multiple cranial nerve palsy. ( 28993357 )
2017
8
Cranial nerve palsy following central neuraxial block in obstetrics - a review of the literature and analysis of 43 case reports. ( 28343842 )
2017
9
Neurological Imaging in Acquired Cranial Nerve Palsy: Ophthalmologists vs. Neurologists. ( 28759288 )
2017
10
Cranial Nerve Palsy after Onyx Embolization as a Treatment for Cerebral Vascular Malformation. ( 29159152 )
2017
11
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome. ( 28211985 )
2017
12
Imaging of Oculomotor (Third) Cranial Nerve Palsy. ( 27886888 )
2017
13
Carcinoma Prostate Presenting as Multiple Cranial Nerve Palsy. ( 28457045 )
2017
14
Isolated sixth Cranial Nerve Palsy in a Case Of Severe Pre-Eclampsia Presenting as Postpartum Diplopia. ( 28969214 )
2017
15
A case of idiopathic hypertrophic pachymeningitis presenting with chronic headache and multiple cranial nerve palsies: A case report. ( 28723776 )
2017
16
Calvarial-orbital Metastasis of Prostate Carcinoma which was Diagnosed with Sixth Cranial Nerve Palsy. ( 29114308 )
2017
17
Ocular cranial nerve palsies secondary to sphenoid sinusitis. ( 29204579 )
2017
18
Disseminated Cryptococcosis with Severe Increased Intracranial Pressure Complicated with Cranial Nerve Palsy in a Child. ( 29189676 )
2017
19
Isolated Third Cranial Nerve Palsy Leading to the Diagnosis of Disseminated Burkitt Lymphoma: A Case Report and Literature Review. ( 28859023 )
2017
20
Perioptic neuritis related with varicella-zoster virus infection preceding sixth cranial nerve palsy and progressive outer retinal necrosis in a immunocompetent patient. ( 28131177 )
2017
21
Lower cranial nerve palsy after the infrafloccular approach in microvascular decompression for hemifacial spasm. ( 28540133 )
2017
22
Relapsing polychondritis as an unusual cause of multiple cranial nerve palsies-A Case report. ( 28093782 )
2017
23
Stroke risk among adult patients with third, fourth or sixth cranial nerve palsy: a Nationwide Cohort Study. ( 28772000 )
2017
24
Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: a single institution experience of 104 patients. ( 28435298 )
2017
25
A case of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated hypertrophic pachymeningitis presenting with multiple cranial nerve palsies and diabetes insipidus. ( 27098904 )
2016
26
A frontal external ventricular drain causing a third cranial nerve palsy. ( 27241884 )
2016
27
Cranial nerve palsy secondary to cerebrospinal fluid diversion. ( 26882270 )
2016
28
A Rare Case of Basioccipital Encephalomeningocele with Tethered Dermoid Presenting as Cranial Nerve Palsy: A Case Report. ( 27318872 )
2016
29
Isolated fourth cranial nerve palsy due to pituitary macroadenoma. ( 28050074 )
2016
30
[Malignant lymphoma presented as recurrent multiple cranial nerve palsy after spontaneous regression of oculomotor nerve palsy: A case report]. ( 26616489 )
2016
31
Third Cranial Nerve Palsy in the Setting of Chikungunya Virus Infection. ( 27246445 )
2016
32
Isolated unilateral sixth cranial nerve palsy: A rare presentation of dengue fever. ( 28461846 )
2016
33
A case of possible paraneoplastic neurological syndrome presenting as multiple cranial nerve palsies associated with gallbladder cancer. ( 27498818 )
2016
34
Cerebrospinal fluid dissemination of anaplastic intraventricular meningioma: report of a case presenting with progressive brainstem dysfunction and multiple cranial nerve palsies. ( 27245327 )
2016
35
Isolated neurosarcoidosis presenting with multiple cranial nerve palsies. ( 27168947 )
2016
36
Radiographic occult cerebellar germinoma presenting with progressive ataxia and cranial nerve palsy. ( 26759273 )
2016
37
A rare case of third cranial nerve palsy. ( 27728318 )
2016
38
Third, Fourth, and Sixth Cranial Nerve Palsies in Pituitary Apoplexy. ( 27436207 )
2016
39
Sixth cranial nerve palsy due to acitretin. ( 25997624 )
2015
40
Tapia's syndrome in the intensive care unit: a rare cause of combined cranial nerve palsy following intubation. ( 26088745 )
2015
41
Occipital condyle fracture and lower cranial nerve palsy after blunt head trauma - a literature review and case report. ( 25897322 )
2015
42
Radiation-induced lower cranial nerve palsy in patients with head and neck carcinoma. ( 26171186 )
2015
43
Sixth cranial nerve palsy caused by gastric adenocarcinoma metastasis to the clivus. ( 25810862 )
2015
44
Residual Strabismus in Children Following Improvement of Cranial Nerve Palsies Affecting Ocular Ductions. ( 26564932 )
2015
45
Management of congenital fourth cranial nerve palsy. ( 24661367 )
2014
46
Isolated third cranial nerve palsy from non-aneurysmal internal carotid artery compression. ( 24652655 )
2014
47
Clinical Features and Outcomes of Strabismus Treatment in Third Cranial Nerve Palsy during a 10-Year Period. ( 25667737 )
2014
48
Transient sixth cranial nerve palsy following orgasm abrogated by treatment with sympathomimetic amines. ( 25134302 )
2014
49
Sixth cranial nerve palsy due to arachnoid cyst. ( 25608227 )
2014
50
Sixth cranial nerve palsy in isolated sphenoid sinusitis: a case report. ( 24647749 )
2014

Variations for Cranial Nerve Palsy

Expression for Cranial Nerve Palsy

Search GEO for disease gene expression data for Cranial Nerve Palsy.

Pathways for Cranial Nerve Palsy

Pathways related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 APC CHN1

GO Terms for Cranial Nerve Palsy

Biological processes related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of signal transduction GO:0009967 8.62 CHN1 LAT

Molecular functions related to Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SH3/SH2 adaptor activity GO:0005070 8.62 CHN1 LAT

Sources for Cranial Nerve Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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