MCID: CRN035
MIFTS: 41

Cranial Nerve Palsy malady

Neuronal diseases category

Summaries for Cranial Nerve Palsy

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32MalaCards
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MalaCards: Cranial Nerve Palsy, also known as cranial nerve paralysis, is related to adenoma and prostatitis. An important gene associated with Cranial Nerve Palsy is NDUFA2 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa), and among its related pathways are Citric acid cycle (TCA cycle) and Glycolysis and gluconeogenesis (short map). The compounds UBIQUINONE-1 and exisulind have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and t cells.

Aliases & Classifications for Cranial Nerve Palsy

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Sources:
8Disease Ontology, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

cranial nerve palsy 8
cranial nerve paralysis 8
cranial nerve palsies 60


External Ids:

Disease Ontology8 DOID:3817
NCIt39 C26941
SNOMED-CT56 73013002
MeSH34 D003389

Related Diseases for Cranial Nerve Palsy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Multiple Cranial Nerve Palsy family:

cranial nerve palsy

Diseases related to Cranial Nerve Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.4APC
2prostatitis30.1KLK3
3paraganglioma and gastric stromal sarcoma30.1SDHD, SDHC
4chondroma30.1SDHC, SDHD
5neurofibromatosis30.1SDHC, SDHD
6multiple cranial nerve palsy10.9
7fourth cranial nerve palsy10.7
8carotid artery dissection10.6
9meningitis10.6
10familial congenital fourth cranial nerve palsy10.6
11cerebritis10.5
12wegener's granulomatosis10.5
13pituitary apoplexy10.5
14nasopharyngitis10.5
15cerebral palsy10.5
16intracranial hypotension10.5
17systemic lupus erythematosus10.4
18herpes zoster10.4
19lupus erythematosus10.4
20neuropathy10.4
21melkersson-rosenthal syndrome10.4
22cranial nerve disease10.4
23lemierre's syndrome10.3
24wound botulism10.3
25aseptic meningitis10.3
26arachnoiditis10.3
27intracranial aneurysm10.3
28lyme disease10.3
29hepatitis b10.3
30infectious mononucleosis10.3
31adult-onset still's disease10.3
32bacterial meningitis10.3
33botulism10.3
34hepatitis10.3
35hypopituitarism10.3
36leukemia10.3
37migraine10.3
38multiple myeloma10.3
39myeloma10.3
40otitis externa10.3
41retinitis10.3
42rhabdomyosarcoma10.3
43sarcoidosis10.3
44brown-vialetto-van laere syndrome 110.3
45tolosa-hunt syndrome10.1
46bell's palsy10.1
47sc phocomelia syndrome10.1
48diabetic autonomic neuropathy10.1
49oculomotor nerve paralysis10.1
50autonomic neuropathy10.1

Graphical network of the top 20 diseases related to Cranial Nerve Palsy:



Diseases related to cranial nerve palsy

Clinical Features for Cranial Nerve Palsy

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Drugs & Therapeutics for Cranial Nerve Palsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cranial Nerve Palsy

Drug clinical trials:

Search ClinicalTrials for Cranial Nerve Palsy

Search NIH Clinical Center for Cranial Nerve Palsy

Search CenterWatch for Cranial Nerve Palsy

Genetic Tests for Cranial Nerve Palsy

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Anatomical Context for Cranial Nerve Palsy

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Sources:
32MalaCards
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MalaCards organs/tissues related to Cranial Nerve Palsy:

32
Pituitary, Brain, T cells, Tongue, Cervix, Prostate, Salivary gland, Colon, Eye, Cortex

Animal Models for Cranial Nerve Palsy or affiliated genes

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Publications for Cranial Nerve Palsy

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Sources:
50PubMed
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Articles related to Cranial Nerve Palsy:

(show top 50)    (show all 232)
idTitleAuthorsYear
1
Unusual aetiology of isolated lower motor neuron facial palsy: systemic lupus erythematosus presenting with cranial nerve palsy and nephritis. (23978499)
2013
2
Ophthalmoplegic migraine with isolated third cranial nerve palsy in a known case of juvenile myoclonic epilepsy. (24296772)
2013
3
Glufosinate herbicide intoxication causing unconsciousness, convulsion, and 6th cranial nerve palsy. (24265537)
2013
4
Cranial nerve palsies: sarcoidosis to systemic lupus erythematosus. (23401835)
2013
5
Lemierre syndrome associated with 12th cranial nerve palsy--a case report and review. (23845534)
2013
6
Perimesencephalic subarachnoid hemorrhage associated with a painless, pupillary-involving third cranial nerve palsy: case report and literature review. (22410651)
2012
7
An unusual case of isolated sixth cranial nerve palsy in leprosy. (22948066)
2012
8
Multiple cranial nerve palsies as the initial presentation of peripheral T-cell lymphoma. (23073132)
2012
9
Partial third cranial nerve palsy: clinical characteristics and surgical management. (22687316)
2012
10
Cavernous sinus apoplexy presenting isolated sixth cranial nerve palsy: case report. (21503686)
2012
11
Recurrent hemorrhagic bullae of oral cavity and cranial nerve palsy: two rare manifestations at the onset of light chain (AL) amyloidosis in the same patient. (21838456)
2011
12
Images in clinical medicine. Internal-carotid-artery dissection and cranial-nerve palsies. (22150058)
2011
13
Cranial nerve palsies in typhoid fever: report of three cases. (21781422)
2011
14
Pituitary apoplexy with third cranial nerve palsy after off-pump coronary artery bypass grafting. (21527463)
2011
15
Isolated third cranial nerve palsy: a rare presentation of neurocysticercosis. (19340520)
2011
16
Third cranial nerve palsy as the presenting neuro-ophthalmic feature of nasopharyngeal carcinoma. (20182221)
2010
17
Intentional sparing of daughter sac from coil packing in the embolization of aneurysms causing the third cranial nerve palsy : initial clinical and radiological results. (20856658)
2010
18
Complete Melkersson-Rosenthal syndrome with multiple cranial nerve palsies. (20500200)
2010
19
Sixth cranial nerve palsy and contralateral hemiparesis (Raymond's syndrome) sparing the face. (19252793)
2009
20
Cranial nerves palsy as an initial feature of an early onset distal hereditary motor neuropathy--a new distal hereditary motor neuropathy phenotype. (19409784)
2009
21
Imaging of intracranial aneurysms causing isolated third cranial nerve palsy. (19726948)
2009
22
Delayed third cranial nerve palsy after aneurysm wrapping. (19145142)
2008
23
Management of intracranial aneurysm causing a third cranial nerve palsy: MRA, CTA or DSA? (18432540)
2008
24
Spontaneous resolution of a Meckel's cave arachnoid cyst causing sixth cranial nerve palsy. (18769281)
2008
25
Differential diagnosis and management of acquired sixth cranial nerve palsy. (17145564)
2006
26
Melkersson-Rosenthal syndrome with diffuse facial swelling and multiple cranial nerve palsies. (16700832)
2006
27
Optic neuropathy and sixth cranial nerve palsy caused by compression from a dolichoectatic basilar artery. (16966938)
2006
28
Isolated sixth cranial nerve palsy in preeclampsia. (17204926)
2006
29
Sphenoid sinus mucocele presenting as a third cranial nerve palsy. (16340496)
2005
30
Progressive cranial nerve palsy following shunt placement in an isolated fourth ventricle: case report. (15881761)
2005
31
Bilateral sixth cranial nerve palsy after unintentional dural puncture. (15470172)
2004
32
Vertebrobasilar dolichoectasia presenting as lower cranial nerve palsy. (15269505)
2004
33
Rheumatoid factor positive hypertrophic cranial pachymeningitis in association with hypopituitarism and multiple cranial nerve palsies. (11579967)
2001
34
Painful fourth cranial nerve palsy caused by posteriorly-draining dural carotid-cavernous sinus fistula. (11000739)
2000
35
Cranial nerve palsies and descending paralysis in a drug abuser resulting from wound botulism. (10470586)
1999
36
Leptomeningeal carcinomatosis and cranial nerve palsy as presenting symptoms of a clinically inapparent gallbladder carcinoma. (10448666)
1999
37
Results following treatment of third cranial nerve palsy in children. (10360301)
1998
38
An adult male with myeloradiculopathy and cranial nerve palsy. (7696944)
1995
39
Acute lymphoblastic leukaemia presenting with an isolated sixth cranial nerve palsy in an adult. (9422168)
1994
40
Cranial nerve palsy associated with acute hepatitis B. (8076978)
1994
41
Isolated 5th to 10th cranial nerve palsy in closed head trauma. (1651194)
1991
42
Lower cranial nerve palsy due to dissection of the internal carotid artery: CT and MR imaging. (2584511)
1989
43
Idiopathic third cranial nerve palsy associated with herpes simplex virus infection. (3119055)
1987
44
Variants of Guillain-BarrAc syndrome: Miller Fisher syndrome, facial diplegia and multiple cranial nerve palsies. (3690433)
1987
45
The incidence of extraocular muscle and cranial nerve palsy in orbital floor blow-out fractures. (3627717)
1987
46
Orofacial problems associated with bilateral seventh cranial nerve palsy: report of case. (330604)
1977
47
Giant intracavernous aneurysm: rare cause of isolated sixth cranial nerve palsy in a child. (995017)
1976
48
Proptosis and cranial nerve palsy in a diabetic patient. (4739703)
1973
49
Idiopathic palsy of the recurrent laryngeal nerve: a transient cranial mononeuropathy. (5083885)
1972
50
Meningitis and sixth cranial nerve palsy. (5650980)
1968

Genetic Variations for Cranial Nerve Palsy

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Expression for genes affiliated with Cranial Nerve Palsy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cranial Nerve Palsy

Search GEO for disease gene expression data for Cranial Nerve Palsy.

Pathways for genes affiliated with Cranial Nerve Palsy

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Cranial Nerve Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8SDHD, SDHC
2
Hide members
9.8SDHD, SDHC
3
Hide members
9.8SDHC, SDHD
48.9PGLS, SDHD, SDHC
5
Hide members
8.6PGLS, SLC52A3, SDHD, SDHC

Compounds for genes affiliated with Cranial Nerve Palsy

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Sources:
11DrugBank, 44Novoseek, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Cranial Nerve Palsy according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1UBIQUINONE-11110.0SDHD, SDHC
2exisulind4410.0APC, KLK3
32-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1110.0SDHD, SDHC
4thymine44 2410.9APC, XPC
5fumarate44 1110.9SDHD, SDHC
6lycopene44 2410.9CRP, KLK3
7iron-sulfur449.8SDHD, SDHC
8succinic acid28 11 2411.8SDHD, SDHC
9ubiquinone449.5SDHC, SDHD
10aspirin44 49 28 2412.4APC, KLK3, CRP
11iron44 2410.4NDUFA2, CRP, SDHD, SDHC

GO Terms for genes affiliated with Cranial Nerve Palsy

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16Gene Ontology
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Cellular components related to Cranial Nerve Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057499.8SDHC, SDHD

Biological processes related to Cranial Nerve Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:0060999.8SDHC, SDHD
2respiratory electron transport chainGO:0229049.4SDHC, SDHD, NDUFA2
3cellular metabolic processGO:0442379.2SDHC, SDHD, NDUFA2

Products for genes affiliated with Cranial Nerve Palsy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cranial Nerve Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet