MCID: CRN035
MIFTS: 35

Cranial Nerve Palsy malady

Summaries for Cranial Nerve Palsy

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33MalaCards
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MalaCards: Cranial Nerve Palsy, also known as cranial nerve paralysis, is related to adenoma and paraganglioma and gastric stromal sarcoma. An important gene associated with Cranial Nerve Palsy is NDUFA2 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa), and among its related pathways are Glycolysis and gluconeogenesis (short map) and Pyruvate metabolism. The compounds UBIQUINONE-1 and exisulind have been mentioned in the context of this disorder.

Aliases & Classifications for Cranial Nerve Palsy

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

cranial nerve palsy 8
cranial nerve paralysis 8
cranial nerve palsies 61


External Ids:

Disease Ontology8 DOID:3817
NCIt40 C26941
SNOMED-CT57 73013002
MeSH35 D003389

Related Diseases for Cranial Nerve Palsy

Sources:
17GeneCards, 18GeneDecks
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Diseases in the multiple cranial nerve palsy family:

cranial nerve palsy

Diseases related to Cranial Nerve Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.5APC
2paraganglioma and gastric stromal sarcoma30.2SDHC, SDHD
3neurofibromatosis30.2SDHD, SDHC
4multiple cranial nerve palsy10.8
5fourth cranial nerve palsy10.8
6n syndrome10.8
7carotid artery dissection10.6
8familial congenital fourth cranial nerve palsy10.6
9pituitary apoplexy10.5
10intracranial hypotension10.5
11systemic lupus erythematosus10.4
12herpes zoster10.4
13melkersson-rosenthal syndrome10.4
14lemierre's syndrome10.4
15herpes zoster ophthalmicus10.4
16hepatitis c10.3
17wound botulism10.3
18aseptic meningitis10.3
19intracranial aneurysm10.3
20lyme disease10.3
21infectious mononucleosis10.3
22adult-onset still's disease10.3
23bacterial meningitis10.3
24botulism10.3
25tuberculous meningitis10.3
26venous thrombosis10.3
27brown-vialetto-van laere syndrome 110.3
28tolosa-hunt syndrome10.2
29bell's palsy10.2
30hepatitis d10.2
31oculomotor nerve paralysis10.2
32autonomic neuropathy10.2
33hepatitis c virus10.2
34myokymia10.2
35sneddon syndrome10.1
36renal osteodystrophy10.1
37antiphospholipid syndrome10.1
38relapsing polychondritis10.1
39ankylosing spondylitis10.1
40intestinal botulism10.1
41pseudotumor cerebri10.1
42sapho syndrome10.1
43miller fisher syndrome10.1
44osteitis fibrosa10.1
45infant botulism10.1
46foodborne botulism10.1
47testicular lymphoma10.1
48wegener's granulomatosis10.1
49distal hereditary motor neuropathy10.1
50cadasil10.1

Graphical network of the top 20 diseases related to Cranial Nerve Palsy:



Diseases related to cranial nerve palsy

Clinical Features for Cranial Nerve Palsy

Drugs & Therapeutics for Cranial Nerve Palsy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cranial Nerve Palsy

Drug clinical trials:

Search ClinicalTrials for Cranial Nerve Palsy

Search NIH Clinical Center for Cranial Nerve Palsy

Search CenterWatch for Cranial Nerve Palsy

Genetic Tests for Cranial Nerve Palsy

Anatomical Context for Cranial Nerve Palsy

Animal Models for Cranial Nerve Palsy or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Cranial Nerve Palsy

Sources:
51PubMed
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Articles related to Cranial Nerve Palsy:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Successful endovascular management of brain aneurysms presenting with mass effect and cranial nerve palsy. (22782498)
2013
2
Rhino-oculo Cerebral Mucormycosis with Multiple Cranial Nerve Palsy in Diabetic Patient: Review of Six Cases. (24427603)
2013
3
Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy. (22892236)
2013
4
Lemierre syndrome associated with 12th cranial nerve palsy--a case report and review. (23845534)
2013
5
Ganglion cyst of the temporomandibular joint with intracranial extension in a patient presenting with seventh cranial nerve palsy. (22117183)
2012
6
Midbrain neurocysticercosis presenting as isolated pupil sparing third cranial nerve palsy. (21906754)
2012
7
Prognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma. (22958729)
2012
8
'Man-in-the-barrel' syndrome with bilateral 6th cranial nerve palsy. (23095810)
2012
9
A descending cranial nerve palsy during the christmas holidays. (23983866)
2012
10
Presentation of Bilateral Peripheral Seventh Cranial Nerve Palsy in an HIV Patient. (22934208)
2012
11
Plasmodium falciparum malaria, bilateral sixth cranial nerve palsy and delayed cerebellar ataxia. (22421613)
2012
12
Comparison of primary position measurements and abduction deficit between type 1 Duane syndrome and sixth cranial nerve palsy. (21343829)
2011
13
Long-standing postsurgical lower cranial nerve palsy mimicking a pharyngolaryngeal submucosal mass in an elderly patient. (21959475)
2011
14
Germinoma presenting as a fourth cranial nerve palsy in a patient with adenomatous polyposis coli (APC) gene mutation. (21315632)
2011
15
Pituitary apoplexy with third cranial nerve palsy after off-pump coronary artery bypass grafting. (21527463)
2011
16
Isolated unilateral abducens cranial nerve palsy: a rare presentation of pituitary apoplexy. (19882540)
2010
17
Third cranial nerve palsy as the presenting neuro-ophthalmic feature of nasopharyngeal carcinoma. (20182221)
2010
18
Cranial nerve palsy in multiple myeloma and solitary plasmacytoma. (21114773)
2010
19
Intentional sparing of daughter sac from coil packing in the embolization of aneurysms causing the third cranial nerve palsy : initial clinical and radiological results. (20856658)
2010
20
Cranial nerve palsy in Wegener's granulomatosis--lessons from clinical cases. (19253059)
2009
21
Pituitary apoplexy presenting as isolated third cranial nerve palsy with ptosis : two case reports. (19274125)
2009
22
Searching for brain aneurysm in third cranial nerve palsy. (19726936)
2009
23
Imaging of intracranial aneurysms causing isolated third cranial nerve palsy. (19726948)
2009
24
Delayed third cranial nerve palsy after aneurysm wrapping. (19145142)
2008
25
Unruptured large and giant carotid artery aneurysms presenting with cranial nerve palsy: comparison of clinical recovery after selective aneurysm coiling and therapeutic carotid artery occlusion. (18296545)
2008
26
Central nervous system Aspergillus fumigatus presenting as cranial nerve palsy in a patient with ankylosing spondylitis on anti-TNF therapy. (18381385)
2008
27
Pituitary apoplexy presenting as acute painful isolated unilateral third cranial nerve palsy. (18588383)
2008
28
Cryptococcal meningitis presenting with isolated sixth cranial nerve palsy in a patient with systemic lupus erythematosus. (18303219)
2008
29
Simultaneous ischemic optic neuropathy and third cranial nerve palsy in giant cell arteritis. (18090573)
2007
30
Differential diagnosis and management of acquired sixth cranial nerve palsy. (17145564)
2006
31
Optic neuropathy and sixth cranial nerve palsy caused by compression from a dolichoectatic basilar artery. (16966938)
2006
32
Lemierre's syndrome presenting with peritonsillar abscess and VIth cranial nerve palsy. (16772058)
2006
33
Nasopharyngeal carcinoma with cranial nerve palsy: the importance of MRI for radiotherapy. (16297716)
2005
34
A case of multiple cranial nerve palsy due to sphenoid sinusitis complicated by cerebral aneurysm. (16139977)
2005
35
Third cranial nerve palsy from midbrain neurocysticercosis: repeated exacerbation on tapering corticosteroids. (15348988)
2004
36
A case of neurosarcoidosis presenting with multiple cranial nerve palsy. (12839373)
2003
37
Masked pseudomonal skull base osteomyelitis presenting with a bilateral Xth cranial nerve palsy. (12238681)
2002
38
Tongue deviation in acute ischaemic stroke: a study of supranuclear twelfth cranial nerve palsy in 300 stroke patients. (11070377)
2000
39
A review of 5 years' experience in the use of botulinium toxin A in the treatment of sixth cranial nerve palsy at the Singapore National Eye Centre. (10489509)
1999
40
Unusual cranial nerve palsy caused by cavernous sinus aneurysms. Clinical and anatomical considerations reviewed. (10447280)
1999
41
Transitory fourth cranial nerve palsy due to foramen ovale electrode placement. (9309297)
1997
42
Acute lymphoblastic leukaemia presenting with an isolated sixth cranial nerve palsy in an adult. (9422168)
1994
43
A cranial nerve palsy associated with Mycoplasma pneumoniae infection. Polymerase chain reaction evidence against an infectious mechanism. (8280697)
1993
44
Cranial nerve palsy at high altitude. (8300498)
1993
45
Seventh cranial nerve palsy in a case of viral hepatitis (type B) (1452580)
1992
46
Electrooculography and discriminant analysis in Duane's syndrome and sixth-cranial-nerve palsy. (2004723)
1991
47
Sixth cranial nerve palsy complicating psittacosis. (3236030)
1988
48
The incidence of extraocular muscle and cranial nerve palsy in orbital floor blow-out fractures. (3627717)
1987
49
THE OCULAR SEQUELAE OF THIRD CRANIAL NERVE PALSY. (14069610)
1963
50
Ipsilateral third cranial nerve palsy as a presenting sign in acute subdural haematoma. (13081881)
1953

Genetic Variations for Cranial Nerve Palsy

Expression for genes affiliated with Cranial Nerve Palsy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cranial Nerve Palsy

Search GEO for disease gene expression data for Cranial Nerve Palsy.

Pathways for genes affiliated with Cranial Nerve Palsy

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 30KEGG
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Pathways related to Cranial Nerve Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8SDHC, SDHD
2
Hide members
9.8SDHC, SDHD
3
Hide members
9.8SDHC, SDHD
48.9PGLS, SDHD, SDHC
5
Hide members
8.6SDHC, SDHD, SLC52A3, PGLS

Compounds for genes affiliated with Cranial Nerve Palsy

Sources:
11DrugBank, 45Novoseek, 24HMDB, 29IUPHAR, 50PharmGKB
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Compounds related to Cranial Nerve Palsy according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1UBIQUINONE-11110.0SDHC, SDHD
2exisulind4510.0APC, KLK3
32-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol1110.0SDHC, SDHD
4thymine45 2410.9XPC, APC
5fumarate45 1110.9SDHC, SDHD
6lycopene45 2410.9KLK3, CRP
7iron-sulfur459.8SDHC, SDHD
8succinic acid29 11 2411.8SDHC, SDHD
9ubiquinone459.5SDHC, SDHD
10aspirin45 50 29 2412.4KLK3, APC, CRP
11iron45 2410.4NDUFA2, CRP, SDHD, SDHC

GO Terms for genes affiliated with Cranial Nerve Palsy

Sources:
16Gene Ontology
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Cellular components related to Cranial Nerve Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057499.8SDHC, SDHD

Biological processes related to Cranial Nerve Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:0060999.8SDHC, SDHD
2respiratory electron transport chainGO:0229049.4SDHC, SDHD, NDUFA2
3cellular metabolic processGO:0442379.2SDHC, SDHD, NDUFA2

Products for genes affiliated with Cranial Nerve Palsy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cranial Nerve Palsy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet