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MCID: CRN036

Craniopharyngioma malady
18 drugs, 69 genes, 5 tissues, 1461 related diseases, 26 phenotypes, 61 articles, clinical trials.

Summaries for Craniopharyngioma

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30NIH Rare Diseases, 44Wikipedia, 22MalaCards
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NIH Rare Diseases: A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves). This tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected. Craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or Rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum.[orphanet] Craniopharyngioma is treated with surgery alone or by surgery followed by radiation.30

MalaCards: Craniopharyngioma, also known as craniopharyngioma (morphologic abnormality), is related to papillary craniopharyngioma and thyroid cancer. An important gene associated with Craniopharyngioma is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Signal transduction_PTEN pathway. The drugs prednisone and prednisolone tebutate and the compounds glucose and b 723 have been mentioned in the context of this disorder. Affiliated tissues include brain, b cells and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia: Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs...44 more...

Aliases & Descriptions for Craniopharyngioma

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30NIH Rare Diseases, 6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 27NCIt, 24MeSH
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Aliases & Descriptions:

craniopharyngioma 6 30 8 32 43
craniopharyngioma (morphologic abnormality) 6
dysodontogenic epithelial tumor 30
craniopharyngioma (disorder) 6
craniopharyngeal duct tumor 30
neoplasm of rathke's pouch 6
adamantinomatous tumor 30
rathke's pouch tumor 30
neoplasms 43

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NCIt27 C2964

Related Diseases for Craniopharyngioma

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13GeneCards, 14GeneDecks
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Diseases related to craniopharyngioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1458)
idRelated DiseaseScoreTop Affiliating Genes
1papillary craniopharyngioma31.3CTNNB1, KRT7
2thyroid cancer30.5LGALS1, LGALS3, CALCA, TP63, KRT20
3tongue cancer30.5PCNA, VIM, MKI67, ENG, TP53, CTNNB1
4trophoblastic neoplasm30.3PCNA, LGALS1, CGA, TP63
5ovarian mucinous neoplasm30.2CDX2, TP53, KRT7, KRT20
6colonic neoplasm29.8INS, ICAM1, TP53, CTNNB1
7intraepithelial neoplasm29.3PCNA, MKI67, ERBB2, TP53
8paraurethral gland neoplasm29.3CDX2, KRT7, KRT20
9breast cancer29.2IGF1R, ERBB2, TNC, CTNNB1, KRT14, PRL
10pancreatic cancer29.2LGALS3, S100A6, CEACAM3, CDX2, IGF1R, PTHLH
11parathyroid carcinoma29.2LGALS3, MKI67, CALCA, TP53, KRT14
12brain cancer29.1LGALS1, MAP2, TP53, TNC, PTPRC, PDGFB
13pancreatic ductal carcinoma28.7KRT8, KRT7, KRT20
14mesenchymal cell neoplasm28.7PCNA, IGF1, GFAP
15squamous cell carcinoma28.7LGALS1, LGALS3, MKI67, CCNA2, PTHLH, EPCAM
16apocrine sweat gland neoplasm28.4CD34, KRT14
17choroid plexus carcinoma28.2TP53, PDGFRA, PDGFRB
18basal cell carcinoma28.1LGALS1, LGALS3, S100A2, CD34, MKI67, TP53
19prolactin producing pituitary tumor27.9TRH, PRL, POMC
20pituitary tumor27.5LGALS3, IGF1, GH1, GHRL, TRH, PTTG1
21mantle cell lymphoma27.4MKI67, MCM6, MAP2, CCNA2, IGF1R, TP53
22mucinous cystadenocarcinoma27.4CEACAM3, KRT7, KRT20
23neuroendocrine tumor27.3CEACAM3, CDX2, MKI67, IGF1R, CALCA, GH1
24malignant peripheral nerve sheath tumor27.3VIM, S100A1, S100A6, CD34, PDGFRA, TOP2A
25panhypopituitarism27.2AVP, IGF1, CALCA, GH1, GHRL, ELANE
26giant cell tumor27.1VIM, CEACAM3, CALCA, PTPRC, CTSB
27male breast cancer27.0PCNA, LGALS1, ERBB2, TP53, PRL
28lung benign neoplasm27.0RARB, LGALS1, MAP2, TP53, CTSB, PDGFA
29angiomyolipoma26.8VIM, S100A1, IL6, TP53, PTPRC, KRT7
30skin cancer26.8PCNA, VIM, RARS, LGALS3, CHKA, CDX2
31gestational trophoblastic tumor26.8PCNA, LGALS3, CGA
32spiradenoma26.7S100A1, TP53, KRT7, KRT14
33functioning pituitary adenoma26.7PCNA, LEP, CGA, MKI67, IGF1, GH1
34myelofibrosis26.6RARB, CD34, ENG, TP53, PTPRC, PDGFRA
35liver cancer26.5RARB, LEF1, S100A6, CEACAM3, INS, IL6
36t-cell leukemia26.5LGALS1, LGALS3, IL1A, ICAM1, PTHLH, PTPRC
37prader-willi syndrome26.5LEP, INS, IGF1, GH1, GHRL, TRH
38testicular cancer26.4LGALS1, CGA, MKI67, IL6, CCNA2, IGF1
39pleomorphic xanthoastrocytoma26.4CD34, TP53, GFAP
40familial adenomatous polyposis26.3PCNA, VIM, RARB, LEF1, CDX2, TP53
41granular cell tumor26.3VIM, S100A1, CEACAM3, MKI67, IGF1, GFAP
42cystadenocarcinoma26.3PCNA, VIM, CEACAM3, TP53, PTPRC, KRT7
43chromophobe renal cell carcinoma26.3PCNA, VIM, RARB, S100A1, KRT8, KRT7
44breast malignant phyllodes tumor26.2VIM, MKI67, CCNA2, TP63
45dermatofibrosarcoma protuberans26.2VIM, S100A1, CD34, TP53, PDGFB, PDGFRA
46hypogonadotropism26.2BRD2, LEP, CGA, INS, GHRL, NR5A1
47mixed cell type cancer26.1VIM, ERBB2, TP53, KRT7, KRT20, KRT14
48urinary bladder cancer26.0MKI67, ERBB2, TP53, CTSB, KRT8, KRT20
49paraneoplastic syndromes26.0CHKA, IL6, CALCA, PTHLH
50synovial sarcoma26.0VIM, MKI67, IGF1R, CTNNB1, KRT8, KRT7

Graphical network of the top 20 diseases related to craniopharyngioma:



Graphical network of diseases related to craniopharyngioma

Clinical Features for Craniopharyngioma

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Drugs & Therapeutics for Craniopharyngioma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

Genetic Tests for Craniopharyngioma

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Anatomical Context for Craniopharyngioma

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22MalaCards
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MalaCards organs/tissues related to craniopharyngioma:

22
Brain, B cells, Endothelial, Hypothalamus, Pituitary

Phenotypes for genes affiliated with Craniopharyngioma

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25MGI
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MGI Mouse Phenotypes related to craniopharyngioma:

25 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:00053799.9POU1F1, PROP1, HESX1, NR5A1, TP63, TRH
2respiratory system phenotypeMP:00053889.9PROP1, HESX1, HCRT, PDGFB, PTPRC, TP63
3craniofacial phenotypeMP:00053829.4POU1F1, HESX1, PDGFRB, PDGFRA, IGF1R, ENAM
4hematopoietic system phenotypeMP:00053978.9PTPRC, PDGFB, PDGFRA, KRT8, POU1F1, EPCAM
5pigmentation phenotypeMP:00011868.9KRT14, PDGFRA, PDGFB, CTNNB1, TP53, LEF1
6renal/urinary system phenotypeMP:00053678.6PDGFRB, PDGFRA, PDGFB, PDGFA, CTSB, CTNNB1
7embryogenesis phenotypeMP:00053808.4CTNNB1, NR5A1, PDGFRA, KRT8, HESX1, PRL
8limbs/digits/tail phenotypeMP:00053718.1PDGFRA, CTNNB1, PTHLH, TP63, ERBB2, IGF1R
9normal phenotypeMP:00028738.0PTPRC, CTSB, NR5A1, PDGFRA, ELANE, HESX1
10reproductive system phenotypeMP:00053897.8KRT8, PDGFRA, PDGFB, PDGFA, NR5A1, TP63
11liver/biliary system phenotypeMP:00053707.8PRL, PTPRC, TP53, GH1, IL6, INS
12nervous system phenotypeMP:00036317.6EPCAM, NES, POU1F1, POMC, PROP1, PRL
13integument phenotypeMP:00107717.2CTNNB1, CTSB, PDGFRA, KRT14, PRL, POMC
14adipose tissue phenotypeMP:00053756.8GHRL, TP53, PTHLH, PTTG1, PDGFRB, POMC
15mortality/agingMP:00107686.5EPCAM, NES, POU1F1, PROP1, GFAP, HESX1
16vision/eye phenotypeMP:00053916.4PTHLH, CTNNB1, PDGFB, PDGFRB, KRT14, HESX1
17immune system phenotypeMP:00053876.3LGALS1, BRD2, VIM, LGALS3, PDGFRA, CTSB
18behavior/neurological phenotypeMP:00053866.2PTHLH, PTTG1, CTNNB1, CTSB, NR5A1, PDGFRA
19skeleton phenotypeMP:00053905.9ERBB2, TP53, TP63, PTHLH, PTPRC, CTNNB1
20muscle phenotypeMP:00053695.8TP53, TP63, CTNNB1, PDGFA, PDGFB, PDGFRA
21tumorigenesisMP:00020065.4TP63, PTPRC, CTNNB1, CTSB, PDGFRA, KRT14
22digestive/alimentary phenotypeMP:00053815.1PTHLH, PTPRC, CTNNB1, CTSB, PDGFRA, PDGFRB
23growth/size phenotypeMP:00053784.4PDGFA, NR5A1, CTSB, CTNNB1, PTPRC, PTTG1
24cardiovascular system phenotypeMP:00053853.9NR5A1, CTNNB1, PTHLH, TP63, TP53, PDGFA
25cellular phenotypeMP:00053843.5CTSB, CTNNB1, PTPRC, PTTG1, PTHLH, TP63
26homeostasis/metabolism phenotypeMP:00053762.0POU1F1, NR5A1, CTSB, CTNNB1, PTPRC, PTTG1

Publications for genes affiliated with Craniopharyngioma

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35PubMed
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Articles related to craniopharyngioma:

(show top 50)    (show all 61)
idTitleAuthorsYearAffiliating Genes
1Delayed ghrelin suppression following oral glucose to lerance test in children and adolescents with hypothalamic injury secondary to craniopharyngioma compared with obese controls. (21050078)O'Gorman C.S.... Hamilton J.2011GHRL
2Expression of angiogenic factors in craniopharyngioma s: implications for tumor recurrence. (20190664)Sun H.I.... Kilic T.2010PDGFRA, PDGFRB, PDGFB
3A tumor-specific cellular environment at the brain in vasion border of adamantinomatous craniopharyngiomas. (20069432)Burghaus S.... Buslei R.2010VIM, TNC, GFAP
4CTNNB1 gene mutations, pituitary transcription factor s, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas. (21761366)Campanini M.L.... de Castro M.2010CTNNB1, PROP1, POU1F1
5Target gene activation of the Wnt signaling pathway i n nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngioma s. (18540944)HAPlsken A.... Buslei R.2009CTNNB1
6Acute pancreatitis in a girl with panhypopituitarism due to craniopharyngioma on growth hormone treatment. A combination of risk fac tors. (19506396)Faienza M.F.... Cavallo L.2009ELANE, GHRL
7Distal gastric bypass surgery for the treatment of hy pothalamic obesity after childhood craniopharyngioma. (19411299)Schultes B.... Thurnheer M.2009IGF1
8Expression of epithelial cell adhesion molecule and pituitary tumor transforming gene in adamantinomatous craniopharyngioma and its correlation with recurrence of the tumor. (19302955)Tena-Suck M.L.... SA!nchez A.2009EPCAM, PTTG1
9Postoperative pituitary hormonal disturbances and hormone replacement therapy time and dosage in children with craniopharyngiomas. (19080279)Li G.M.... Shao P.2008IGF1, PRL
10Composite pituitary adenoma and craniopharyngioma?: an unusual sellar neoplasm with divergent differentiation. (18769335)Yoshida A.... Rosenblum M.K.2008NR5A1, POU1F1
11Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. (17410335)Xu J.... Wang X.2007TOP2A, MCM6
12Growth of craniopharyngioma involving the third ventricular floor in relation to the hypothalamus (17425998)Liu B.G.... Fang L.X.2007PTPRC, ICAM1
13Gastric bypass surgery for treatment of hypothalamic obesity after craniopharyngioma therapy. (17643131)Inge T.H.... TschAPp M.H.2007LEP, GHRL
14Nuclear beta-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas. (17221204)Buslei R.... BlA1mcke I.2007CTNNB1
15Morphological and ultrastructural findings of prognostic impact in craniopharyngiomas. (16825115)Agozzino L.... Cuccurullo L.2006PCNA
16Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas. (16500745)Tena-Suck M.L.... Arrieta O.2006CEACAM3
17Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients. (16700320)MA1ller H.L.... Handwerker G.2006HCRT
18Craniopharyngiomas in the adults (16209298)2005ERBB2, KRT14
19Hypersomnolence and increased REM sleep with low cerebrospinal fluid hypocretin level in a patient after removal of craniopharyngioma. (16084764)Tachibana N.... Nishino S.2005HCRT
20Angiogenesis in craniopharyngiomas: Microvascular density and tissue expression of the vascular endothelial growth factor (VEGF) and endostatin. (16627922)Dallago C.M.... Ferreira N.P.2005CD34, ENG
21Monitoring the expression profiles of integrins and adhesion/growth-regulatory galectins in adamantinomatous craniopharyngiomas: their ability to regulate tumor adhesiveness to surrounding tissue and their contribution to prognosis. (15792515)Lefranc F.... Kiss R.2005LGALS1, ADAMTSL1
22Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. (16000560)Ulfarsson E.... Girnita L.2005IGF1R, IGF1
23Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma. (15687345)Goldstone A.P.... Korbonits M.2005GHRL
24Beta-catenin mutations in craniopharyngiomas and pituitary adenomas. (15980970)Oikonomou E.... Adams E.F.2005CTNNB1
25The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma. (15817911)Kendall-Taylor P.... Verhelst J.2005IGF1
26Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas. (15043773)Zhou Z.Q.... Shi X.E.2004POMC
27Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma. (15221941)Kato K.... Tanaka Y.2004CTNNB1
28Correlation between clinical characteristics and proliferative activity in patients with craniopharyngioma. (15146007)Losa M.... Giovanelli M.2004CCNA2, MKI67
29Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation. (15375575)Mori M.... Kuratsu J.2004IL6, IL1A
30Cathepsin B, D and K expression in adamantinomatous craniopharyngiomas relates to their levels of differentiation as determined by the patterns of retinoic acid receptor expression. (14636257)Lubansu A.... Lefranc F.2003CTSB, RARB
31Growth hormone treatment in pituitary insufficiency: selected cases of children with craniopharyngioma and medulloblastoma. (14737937)Kedzia A.... GoA_dzicka-JA^zefiak A.2003INS
32Immunohistochemical analysis of the p53 family members in human craniopharyngiomas. (14756444)Momota H.... Sato N.2003TP63
33beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst. (14608900)Hassanein A.M.... Liu C.2003CTNNB1
34Differential expression of S100 calcium-binding proteins in epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas. (12653951)Pelc P.... Decaestecker C.2003S100A2, S100A6, S100A1
35Characterization of the levels of expression of retinoic acid receptors, galectin-3, macrophage migration inhibiting factor, and p53 in 51 adamantinomatous craniopharyngiomas. (12546363)Lefranc F.... Kiss R.2003TP53, RARB, LGALS3
36Craniopharyngioma: a case report and comparative galectin histochemical analysis. (12495217)PlzA!k J.... Gabius H.J.2002LGALS3, LGALS1
37Expression of proliferating cell nuclear antigen in craniopharyngioma and tumor recurrence (12390748)Pan J.... Li X.Q.2002PCNA
38Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. (12466115)Sekine S.... Hirohashi S.2002CTNNB1
39Successful pregnancy following gonadotropin therapy in a patient with hypogonadotropic hypogonadism resulting from craniopharyngioma. (11926704)Hayashi M.... Ohkura T.2002CGA
40Precocious puberty associated with growth hormone deficiency in a patient with craniopharyngioma: report of one case. (11550415)Chen Y.D.... Ho W.L.2001INS
41Different keratin profiles in craniopharyngioma subtypes and ameloblastomas. (11770017)Tateyama H.... Eimoto T.2001KRT8, KRT14, KRT7
42Hormonal factors influencing weight and growth pattern in craniopharyngioma. (11044799)Pinto G.... Brauner R.2000IGF1
43Proliferative activity in craniopharyngiomas: clinico pathological correlations in adults and children. (11118571)Raghavan R.... Rushing E.J.2000MKI67
44Severe hypoglycemia and reduction of insulin requirement in a girl with insulin-dependent diabetes mellitus: first sign of a craniopharyngioma. (10703545)Lebl J.... KolouskovA! S.1999GH1
45Growth in children with craniopharyngioma following surgery. (10209560)Tiulpakov A.N.... Gorelyshev S.K.1998IGF1
46Hypothalamic-pituitary dysfunction in patients with craniopharyngioma. (7621564)Paja M.... Estrada J.1995INS, TRH
47A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma (8164804)Kano T.... Nakazato Y.1994VIM
48Craniopharyngioma: endocrine sequelae of treatment. (7841071)Sklar C.A.1994GH1
49Could craniopharyngiomas produce pituitary hormones? (8098858)Szeifert G.T.... PA!sztor E.1993PRL, GH1
50Demonstration of insulin-like growth factors I, II and heterogeneous insulin-like growth factor binding proteins in the cyst fluid of patients with craniopharyngioma. (1719442)Zumkeller W.... Hall K.1991IGF1

Expression for genes affiliated with Craniopharyngioma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Craniopharyngioma

Pathways for genes affiliated with Craniopharyngioma

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36QIAGEN, 41Thomson Reuters, 10EMD Millipore, 20KEGG
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Pathways related to craniopharyngioma according to GeneDecks:

(show top 50)    (show all 72)
idPathwayScoreTop Affiliating Genes
1Actin-Based Motility by Rho Family GTPases3610.4IGF1, GH1
2Signal transduction_PTEN pathway4110.1IGF1R, PCNA
3Signal transduction PTEN pathway1010.0IGF1, IGF1R, LEF1, PCNA
4Breast Cancer Regulation by Stathmin1369.6PDGFB, PDGFA, ERBB2, IGF1R
5Ras Pathway369.6PDGFB, PDGFA, ERBB2, IGF1R
6ERK5 Signaling369.6PDGFRB, PDGFRA, PDGFB, PDGFA, GH1, IL6
7Paxillin Interactions369.5PDGFRB, PDGFRA, PDGFB, PDGFA, ERBB2, GH1
8Epithelial Adherens Junctions369.5PDGFB, PDGFA, CTNNB1, PTPRC, ERBB2, GH1
9Focal adhesion209.5PDGFRB, PDGFRA, PDGFB, PDGFA, CTNNB1, TNC
10Transcription_Role of VDR in regulation of genes involved in osteoporosis419.4CALCA, IGF1, IL6, IL1A, CDX2, CGA
11Transcription Role of VDR in regulation of genes involved in osteoporosis109.4CALCA, IGF1, IL6, IL1A, CDX2, CGA
1214-3-3 Induced Intracellular Signaling369.3PDGFRB, PDGFRA, PDGFB, ERBB2, GH1, IGF1
13Akt Signaling369.3PDGFRB, PDGFRA, PDGFB, PDGFA, IGF1R, IL6
14Nuclear Receptor Activation by Vitamin-A369.2PDGFRB, PDGFRA, PDGFB, PDGFA, GH1, IGF1
15DHA Signaling369.2PDGFRB, PDGFRA, PDGFB, PDGFA, GH1, IGF1
16PPAR Pathway369.1PDGFRB, PDGFRA, PDGFB, GH1, IGF1, IGF1R
17Glioma209.1PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, IGF1
18Melanoma209.1PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, IGF1
19Glioblastoma Multiforme369.1PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, IGF1R
20JNK Pathway368.9PDGFRB, PDGFRA, PDGFB, TP53, MAP2, IL6
21Cytokine-cytokine receptor interaction208.9PRL, PDGFRB, PDGFRA, PDGFB, PDGFA, GH1
22PTEN Pathway368.9PDGFRB, PDGFRA, PDGFB, PDGFA, TNC, TP53
23Rac1 Pathway368.8PDGFRB, PDGFB, PDGFA, GH1, IGF1, IGF1R
24eIF2 Pathway368.8PDGFRB, PDGFRA, PDGFB, PDGFA, GH1, IGF1
25p70S6K Signaling368.7PDGFRB, PDGFRA, PDGFB, PDGFA, GH1, IGF1
26Nanog in Mammalian ESC Pluripotency368.7PDGFRB, PDGFRA, PDGFB, PDGFA, CTNNB1, ERBB2
27Molecular Mechanisms of Cancer368.7PDGFRA, PDGFB, PDGFA, CTNNB1, TP53, GH1
28Pathways in cancer208.6PDGFRA, PDGFA, CTNNB1, TP53, ERBB2, IGF1R
29Rap1 Pathway368.6PDGFRB, PDGFRA, PDGFB, PDGFA, ERBB2, GH1
30GSK3 Signaling368.6PDGFRB, PDGFRA, PDGFB, PDGFA, CTNNB1, ERBB2
31eNOS Signaling368.5PDGFRB, PDGFRA, PDGFB, PDGFA, ERBB2, GH1
32Apoptotic Pathways in Synovial Fibroblasts368.5PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, GH1
33p53 Mediated Apoptosis368.5PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, GH1
34Telomerase Components in Cell Signaling368.5PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, GH1
35Mitochondrial Apoptosis368.5PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, GH1
36NFAT in Immune Response368.5PDGFRB, PDGFRA, PDGFB, PDGFA, ERBB2, GH1
37Cellular Apoptosis Pathway368.5PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, GH1
38PAK Pathway368.5PDGFRB, PDGFRA, PDGFB, PDGFA, GH1, IGF1
39Estrogen Pathway368.4PDGFRB, PDGFRA, PDGFB, PDGFA, ERBB2, GH1
40Activation of PKA through GPCR368.3PDGFRB, PDGFRA, PDGFB, PDGFA, PTPRC, ERBB2
41Rho Family GTPases368.3GFAP, PDGFRB, PDGFRA, PDGFB, PDGFA, TNC
42GPCR Pathway368.3PDGFRB, PDGFRA, PDGFB, PDGFA, ERBB2, GH1
43JAK-STAT Pathway368.3PDGFB, PDGFRA, PDGFRB, PRL, PDGFA, ERBB2
44ILK Signaling368.2CTNNB1, PDGFA, PDGFB, PDGFRA, PDGFRB, TNC
45Tec Kinases Signaling368.2PDGFRB, PDGFRA, PDGFB, PDGFA, ERBB2, GH1
46ERK Signaling368.2PDGFRB, PDGFRA, PDGFB, PDGFA, TNC, ERBB2
47Prostate cancer207.8LEF1, PDGFRB, PDGFRA, PDGFB, PDGFA, CTNNB1
48Pancreatic Adenocarcinoma367.7TP53, PDGFA, PDGFB, PDGFRA, PDGFRB, ERBB2
49p38 Signaling367.4PDGFRB, PDGFRA, PDGFB, PDGFA, TP53, ERBB2
50MAPK Signaling367.4TNC, PDGFA, PDGFB, PDGFRA, PDGFRB, TP53

Compounds for genes affiliated with Craniopharyngioma

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
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Compounds related to craniopharyngioma according to GeneDecks:

(show top 50)    (show all 275)
idCompoundScoreTop Affiliating Genes
1glucose32 9.8LGALS1, AVP, MKI67, CCNA2, TRH, PTHLH
2b 72332 9.4PCNA, VIM, CHKA, S100A1, CEACAM3, TP63
3dopamine32 9 18 9 12.4RARB, CGA, MAP2, CCNA2, GH1, GHRL
4agar32 8.9VIM, RARB, LGALS1, CD34, ENG, IGF1R
5estradiol32 9 18 9 11.7PCNA, VIM, RARB, CHKA, CGA, MKI67
6gnrh32 8.4VIM, LEP, MKI67, INS, IGF1, GH1
7tgf beta132 8.4MKI67, IL6, ENG, CCNA2, TNC, PTHLH
8epinephrine32 9 18 9 11.4LEP, CGA, INS, IL1A, GHRL, ELANE
9cysteine32 8.4PCNA, RARB, LGALS1, LGALS3, S100A1, S100A2
10hematoxylin32 8.2PCNA, VIM, LGALS3, CHKA, S100A1, CEACAM3
11h2o232 8.1LGALS3, LEP, CGA, IGF1R, ICAM1, GH1
12octreotide32 42 9 9 11.1MKI67, INS, IGF1R, IGF1, CALCA, GH1
13ribonucleic acid32 8.0RARB, CGA, IL1A, IGF1R, IGF1, GH1
14matrigel32 8.0VIM, LGALS1, LGALS3, LEF1, ENG, IGF1R
15bromodeoxyuridine32 8.0PCNA, VIM, RARS, MKI67, MAP2, CCNA2
16forskolin32 42 9 9 10.8VIM, RARS, RARB, CGA, IL1A, CCNA2
17creatinine32 7.7PCNA, LEP, CHKA, CGA, CEACAM3, IL1A
18thyroxine32 18 8.6PCNA, LEP, CHKA, CGA, CEACAM3, INS
19heparin32 9 18 9 10.5VIM, LGALS1, LGALS3, CGA, MAP2, ERBB2
20calcium32 9 18 9 10.5LGALS1, LGALS3, CHKA, S100A1, S100A2, S100A3
21arginine32 7.3RARS, RARB, LGALS1, LEP, CGA, AVP
22glycogen32 18 8.2VIM, LGALS3, LEF1, CHKA, S100A1, MKI67
23acth32 7.1LGALS3, LEP, AVP, CEACAM3, INS, IL1A
24oligonucleotide32 7.1PCNA, VIM, RARB, LGALS3, S100A2, S100A6
25norepinephrine32 9 18 9 10.1LEP, S100A6, CGA, AVP, INS, IL1A
26genistein32 9 18 9 9.9PCNA, VIM, RARB, CHKA, IL1A, IL6
27hydrocortisone32 9 9 8.8VIM, INS, IL1A, IL6, IGF1, CALCA
28acetylcholine32 9 18 9 9.8VIM, LEP, CHKA, S100A1, CGA, IL1A
29steroid32 6.8RARS, RARB, LEP, CHKA, S100A6, CGA
30tamoxifen32 34 9 9 9.8PCNA, VIM, LEP, CHKA, CGA, CEACAM3
31glutamate32 6.7PCNA, VIM, LGALS3, LEP, CHKA, INS
32lipid32 6.7VIM, RARB, LGALS1, LGALS3, LEP, CHKA
33doxorubicin32 34 9 9 9.6VIM, CHKA, CGA, CEACAM3, MKI67, ENG
34actinomycin d32 6.6VIM, RARB, CGA, IL1A, IL6, IGF1R
35vitamin d32 6.6VIM, RARS, RARB, LGALS3, CHKA, CGA
36progesterone32 42 9 18 9 10.5PCNA, RARS, RARB, CHKA, S100A1, S100A6
37alanine32 6.5PCNA, LGALS3, LEF1, CHKA, CGA, AVP
38paclitaxel32 34 9 9 9.3PCNA, VIM, MKI67, IL1A, MAP2, CCNA2
39retinoic acid32 42 18 8.2RARS, RARB, LGALS3, CHKA, S100A6, CD34
40cisplatin32 34 9 9 9.0PCNA, RARB, LGALS3, LEF1, LEP, CGA
41testosterone32 9 18 9 8.8PCNA, VIM, RARS, RARB, CHKA, S100A6
42lactate32 5.4PCNA, VIM, LGALS3, CHKA, CGA, CEACAM3
43thymidine32 18 6.2PCNA, RARS, RARB, CHKA, CEACAM3, CD34
44cycloheximide32 4.5VIM, RARB, LEP, CGA, MKI67, IL1A
45dexamethasone32 42 34 9 9 8.4PCNA, VIM, RARB, LGALS1, LEP, CHKA
46tyrosine32 3.6RARB, LGALS1, LGALS3, LEF1, CHKA, S100A1
47estrogen32 3.6PCNA, RARS, RARB, LGALS3, LEP, CHKA
48paraffin32 3.5PCNA, VIM, LGALS1, LGALS3, LEP, CHKA
49serine32 3.5VIM, LGALS1, LGALS3, LEF1, LEP, CHKA
50vegf32 2.5PCNA, VIM, LGALS3, LEP, CGA, CEACAM3

GO Terms for genes affiliated with Craniopharyngioma

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Sources:
12Gene Ontology
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Cellular components related to craniopharyngioma according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.6NES, GFAP, KRT14, KRT20, KRT7, KRT8
2secretory granuleGO:0301419.1POMC, HCRT, ELANE, TRH, GHRL, INS
3extracellular spaceGO:0056156.7LGALS1, POMC, PDGFA, CTSB, PTHLH, TNC
4extracellular regionGO:0055766.4TNC, PTHLH, PDGFA, PDGFB, ELANE, HCRT
5nucleusGO:0056345.6CTNNB1, PTTG1, PTHLH, TP63, TP53, TRH
6cytoplasmGO:0057375.6PDGFRB, PDGFRA, PDGFB, CTNNB1, PTTG1, PTHLH

Biological processes related to craniopharyngioma according to GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1myoblast differentiationGO:04544510.6CTNNB1, IGF1, LGALS1
2positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayGO:03579310.5PDGFRB, PDGFB, PDGFA
3negative regulation of platelet activationGO:01054410.4PDGFRA, PDGFB, PDGFA
4positive regulation of fibroblast proliferationGO:04814610.3S100A6, IGF1, PDGFA, PDGFB, PDGFRA
5negative regulation of phosphatidylinositol biosynthetic processGO:01051210.3PDGFB, PDGFA
6platelet-derived growth factor receptor signaling pathwayGO:04800810.3PDGFA, PDGFB, PDGFRA, PDGFRB
7positive regulation of smooth muscle cell migrationGO:01491110.2PDGFRB, PDGFB, IGF1
8intermediate filament organizationGO:04510910.2GFAP, KRT20, VIM
9cell chemotaxisGO:06032610.2PDGFRB, PDGFRA, PDGFB, ENG, LEF1
10smooth muscle tissue developmentGO:04874510.2ENG, TP63, PDGFRB
11DNA replicationGO:00626010.1TOP2A, KRT7, PDGFB, IGF1, MCM6, PCNA
12metanephric glomerular mesangial cell proliferation involved in metanephros developmentGO:07226210.1PDGFB, PDGFRB
13response to woundingGO:00961110.1GFAP, PDGFB, PDGFA, CTSB, TNC
14positive regulation of protein autophosphorylationGO:03195410.0PDGFB, PDGFA, INS
15paracrine signalingGO:03800110.0PDGFB, CD34
16elevation of cytosolic calcium ion concentrationGO:00720410.0HCRT, PDGFRA, GHRL, CALCA, AVP
17positive regulation of JAK-STAT cascadeGO:04642710.0PRL, GH1, IL6
18positive regulation of ERK1 and ERK2 cascadeGO:0703749.9IL1A, PDGFA, PDGFB, PDGFRA, PDGFRB
19positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.7PDGFRB, PDGFRA, PDGFB, PDGFA, GH1, IGF1
20positive regulation of smooth muscle cell proliferationGO:0486619.7IL6, IGF1, PDGFB, PDGFRB, ELANE
21positive regulation of mitosisGO:0458409.7PDGFRB, PDGFB, IGF1, IL1A, INS
22monocyte chemotaxisGO:0025489.7PDGFB, CALCA, IL6
23positive regulation of MAP kinase activityGO:0434069.6ELANE, PDGFRB, PDGFB, PDGFA, ERBB2, GH1
24positive regulation of DNA replicationGO:0457409.5PDGFRA, PDGFB, PDGFA, IGF1, IGF1R, INS
25response to organic cyclic compoundGO:0140709.5PDGFB, CTSB, TRH, ICAM1, IL1A, LEF1
26positive regulation of cell migrationGO:0303359.1PDGFRB, PDGFRA, PDGFB, PDGFA, IGF1R, INS
27positive regulation of MAPK cascadeGO:0434109.1PDGFB, PDGFA, PTPRC, IGF1, IL6, INS
28cell-cell signalingGO:0072679.1POMC, PDGFA, NR5A1, PTHLH, TRH, CALCA
29phosphatidylinositol-mediated signalingGO:0480159.0TOP2A, PDGFRB, PDGFRA, ERBB2, IGF1, IGF1R
30wound healingGO:0420609.0PDGFRA, PDGFA, ERBB2, ENG, IL1A, INS
31positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8PDGFB, TP53, GH1, IGF1, IL6, INS
32negative regulation of cell proliferationGO:0082858.6POU1F1, CTNNB1, PTTG1, PTHLH, TP53, IGF1
33positive regulation of transcription, DNA-dependentGO:0458938.6POU1F1, PDGFB, CTNNB1, TP63, TP53, IGF1
34signal transductionGO:0071658.3POMC, PDGFRB, TNC, TRH, ERBB2, IGF1
35positive regulation of cell proliferationGO:0082847.8LEF1, EPCAM, PDGFRB, PDGFRA, PDGFB, PDGFA
36positive regulation of transcription from RNA polymerase II promoterGO:0459447.8CTNNB1, NR5A1, TOP2A, PROP1, POMC, POU1F1
37negative regulation of apoptotic processGO:0430667.8NES, PROP1, TP53, GHRL, IGF1R, IL6

Molecular functions related to craniopharyngioma according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.1PDGFRB, PDGFRA, PDGFB, PDGFA
2platelet-derived growth factor receptor bindingGO:00516110.1PDGFRB, PDGFRA, PDGFB, PDGFA
3cell surface bindingGO:0434989.8ICAM1, PDGFA, PDGFB
4protein homodimerization activityGO:0428039.5TOP2A, PDGFRA, PDGFB, PDGFA, ENG, S100A6
5protein C-terminus bindingGO:0080229.1PROP1, TOP2A, HESX1, CTNNB1, ERBB2, MKI67
6chromatin bindingGO:0036829.0PROP1, TOP2A, HESX1, NR5A1, CTNNB1, TP63
7growth factor activityGO:0080839.0PDGFB, PDGFA, GH1, IGF1, IL6, LEP
8hormone activityGO:0051798.8LEP, POMC, PRL, PTHLH, GH1, CALCA
9identical protein bindingGO:0428027.6TP63, TP53, ERBB2, IGF1R, MCM6, S100A1
10protein bindingGO:0055153.0NR5A1, CTSB, CTNNB1, PTPRC, PTTG1, TP63

Sources for Craniopharyngioma

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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