MCID: CRN036
MIFTS: 62

Craniopharyngioma malady

Neuronal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Craniopharyngioma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves). this tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected. craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum.[orphanet] craniopharyngioma is treated with surgery alone or by surgery followed by radiation. last updated: 4/3/2009

MalaCards: Craniopharyngioma, also known as dysodontogenic epithelial tumor, is related to obesity and adenoma. An important gene associated with Craniopharyngioma is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Glioma and Glioblastoma Multiforme. The compounds cycloheximide and gnrh have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and hypothalamus, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:63 Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs... more...

Aliases & Classifications for Craniopharyngioma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
craniopharyngioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

craniopharyngioma 8 42 10 44 48 60
dysodontogenic epithelial tumor 42
craniopharyngeal duct tumor 42
neoplasm of rathke's pouch 8
adamantinomatous tumor 42
rathke's pouch tumor 42


External Ids:

Disease Ontology8 DOID:3840
MeSH34 D003397
NCIt39 C2964
MESH via Orphanet35 D003397
SNOMED-CT56 40009002, 189179009
ICD10 via Orphanet26 D44.4
SNOMED-CT via Orphanet57 189179009, 40009002
UMLS via Orphanet61 C0010276

Related Diseases for Craniopharyngioma

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17GeneCards, 18GeneDecks
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Diseases related to Craniopharyngioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.9HESX1, HCRT, GH1, IGF1, PROP1
2adenoma30.7PRL, IGF1, BRAF, CTNNB1, GH1, PROP1
3pituitary adenoma30.6GH1, IGF1, PROP1, PRL
4papillary craniopharyngioma30.6KRT7, CTNNB1
5panhypopituitarism30.3GH1, IGF1, PRL, HESX1, PROP1
6astrocytoma30.2RARB, VEGFA, MMP9
7meningioma30.1S100A5
8hypopituitarism30.1PROP1, PRL, IGF1, GH1, HESX1
9chordoma30.0KRT14, KRT7, KRT8
10pilomatrixoma30.0CTNNB1, S100A3
11chromophobe adenoma30.0PRL, GH1
12cholesteatoma29.8RARB, LGALS1, KRT14, MMP9
13prolactinoma29.8PRL, IGF1, GH1
14leukemia29.8RARB, RARS, LGALS1, KRT14
15hypogonadism29.8IGF1, PRL, GH1, PROP1
16hypoglycemia29.8HCRT, GH1, PRL, IGF1
17acromegaly29.8IGF1, GH1, PRL
18hypogonadotropism29.8PRL
19prader-willi syndrome29.8IGF1, GH1, HCRT
20turner syndrome29.7IGF1
21melanoma29.7KRT8, KRT14, RARS, MMP9, HCRT, VEGFA
22anorexia nervosa29.7PRL, GH1, IGF1, HCRT
23cerebritis10.2
24adamantinous craniopharyngioma10.2
25diabetes insipidus10.2
26meningitis10.1
27olfactory neuroblastoma10.0
28central pontine myelinolysis10.0
29anterograde amnesia10.0
30morbid obesity10.0
31adult syndrome10.0
32diabetes mellitus10.0
33functioning pituitary adenoma10.0
34neuroblastoma10.0
35retinitis10.0
36liver cirrhosis10.0KRT8
37neuroendocrine tumor10.0PRL
38galactosemia10.0IGF1
39endometriosis10.0VEGFA
40ductal carcinoma in situ10.0KRT14
41myotonic dystrophy10.0HCRT
42leiomyoma10.0LGALS1
43papilloma10.0KRT14
44colon adenocarcinoma10.0CTNNB1, RARB
45pituitary hypoplasia10.0PROP1, HESX1
46leukoplakia10.0RARB, KRT8
47malignant mesothelioma10.0KRT7
48leiomyosarcoma10.0KRT8, LGALS1
49acanthosis nigricans10.0IGF1
50psoriasis10.0KRT14, RARS

Graphical network of the top 20 diseases related to Craniopharyngioma:



Diseases related to craniopharyngioma

Clinical Features for Craniopharyngioma

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Drugs & Therapeutics for Craniopharyngioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Craniopharyngioma

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Genetic Tests for Craniopharyngioma

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Anatomical Context for Craniopharyngioma

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32MalaCards
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MalaCards organs/tissues related to Craniopharyngioma:

32
Pituitary, Brain, Hypothalamus, Bone, Endothelial, Testes, Skin, Temporal lobe

Animal Models for Craniopharyngioma or affiliated genes

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36MGI
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Publications for Craniopharyngioma

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50PubMed
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Articles related to Craniopharyngioma:

(show top 50)    (show all 577)
idTitleAuthorsYear
1
Mixed pituitary adenoma/craniopharyngioma: clinical, morphological, immunohistochemical and ultrastructural study of a case, review of the literature, and pathogenetic and nosological considerations. (23344977)
2014
2
Primary intracranial ectopic craniopharyngioma in a patient with probable Gardner's syndrome. (24266539)
2013
3
SECONDARY NEUTRON DOSES IN PROTON THERAPY TREATMENTS OF OCULAR MELANOMA AND CRANIOPHARYNGIOMA. (24222710)
2013
4
Recurrent depressive illness or craniopharyngioma: a diagnostic dilemma. (23913493)
2013
5
Radiotherapy for craniopharyngioma. (22948229)
2013
6
Collision tumors of the sella: coexistence of pituitary adenoma and craniopharyngioma in the sellar region. (23919255)
2013
7
Trans-sylvian transtentorial approach for a giant craniopharyngioma of the posterior fossa. (23605374)
2013
8
Transcortical-transforaminal microscopic approach for purely intraventricular craniopharyngioma. (23282157)
2013
9
Predictive factors for craniopharyngioma recurrence: a systematic review and illustrative case report of a rapid recurrence. (22892136)
2013
10
Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies. (23560577)
2013
11
Craniopharyngioma in children: importance of a multidisciplinary approach and therapeutic strategies in the treatment of relapsing]. (24217636)
2013
12
Craniopharyngioma in adults. (22654868)
2012
13
A unique patient presenting with concomitant Klinefelter syndrome, Alport syndrome, and craniopharyngioma. (22518824)
2012
14
Infrasellar craniopharyngioma. (22018920)
2012
15
Appetite-regulating hormone changes in patients with craniopharyngioma. (20379145)
2011
16
Use of combined search criteria improved validity of rare disease (craniopharyngioma) diagnosis in a national registry. (21463925)
2011
17
Introduction: Craniopharyngioma. (20369435)
2010
18
Rapid recurrence of craniopharyngioma following recombinant human growth hormone replacement. (20349266)
2010
19
Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy. (18676089)
2009
20
Late development of craniopharyngioma following surgery for Rathke's cleft cyst. (19537134)
2009
21
Acute pancreatitis in a girl with panhypopituitarism due to craniopharyngioma on growth hormone treatment. A combination of risk factors. (19506396)
2009
22
Panhypopituitarism due to craniopharyngioma associated with hyperthyroidism caused by graves' disease. (22975522)
2008
23
Long-term outcome in children treated for craniopharyngioma with and without radiotherapy. (18352781)
2008
24
Central pontine and extrapontine myelinolysis in an infant associated with the treatment of craniopharyngioma: case report. (18719325)
2008
25
Severe rhabdomyolysis due to adipsic hypernatremia after craniopharyngioma surgery. (18157396)
2007
26
Craniopharyngioma. (17425791)
2007
27
Rupture of a craniopharyngioma cyst following trauma: a case report. (17318439)
2007
28
Malignant astrocytoma following radiotherapy for craniopharyngioma. (17998722)
2007
29
Warfarin induced skin necrosis in a patient with craniopharyngioma. (22266504)
2006
30
Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report. (16630407)
2006
31
Craniopharyngioma. (16922083)
2006
32
Baseline characteristics and response to GH replacement of hypopituitary patients previously irradiated for pituitary adenoma or craniopharyngioma: data from the Pfizer International Metabolic Database. (16868138)
2006
33
More or less? Treatment strategies in childhood craniopharyngioma. (16320024)
2006
34
Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst. (15716233)
2005
35
Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas. (15043773)
2004
36
Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation. (15569047)
2004
37
Delayed persistent hyperthermia after resection of a craniopharyngioma. (15608494)
2004
38
Paediatric craniopharyngioma. (15269087)
2004
39
Changes in height, weight, and body mass index in children with craniopharyngioma after three years of growth hormone therapy: analysis of KIGS (Pfizer International Growth Database). (15531494)
2004
40
Functional capacity, obesity and hypothalamic involvement: cross-sectional study on 212 patients with childhood craniopharyngioma. (14677094)
2003
41
Diencephalic syndrome of emaciation in an adult associated with a third ventricle intrinsic craniopharyngioma: case report. (12493122)
2003
42
The psychosocial impacts on families of low-incidence, complex conditions in children: the case of craniopharyngioma. (14984250)
2003
43
Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. (12466115)
2002
44
Successful management of a symptomatic fusiform dilatation of the internal carotid artery following surgery of childhood craniopharyngioma. (12483358)
2002
45
Differential expression of cytokeratins 8 and 20 distinguishes craniopharyngioma from rathke cleft cyst. (12296753)
2002
46
Infrasellar craniopharyngioma mimicking a clival chordoma: a case report. (12134188)
2002
47
Subependymoma of the third ventricle after partial resection of a craniopharyngioma and repeated postoperative irradiation. (8925598)
1996
48
Pathophysiological and pathogenic interpretation of the clinical picture of chromophobe adenoma of the hypophysis and of craniopharyngioma. (1053393)
1976
49
Recovery from anterograde and retrograde amnesia after percutaneous drainage of a cystic craniopharyngioma. (1011035)
1976
50
Effects of surgical treatment on hypothalamo-pituitary-adrenocortical functions in pituitary chromophobe adenoma and craniopharyngioma. (4548402)
1974

Genetic Variations for Craniopharyngioma

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Expression for genes affiliated with Craniopharyngioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Craniopharyngioma

Search GEO for disease gene expression data for Craniopharyngioma.

Pathways for genes affiliated with Craniopharyngioma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Craniopharyngioma

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Craniopharyngioma according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8KRT8
2gnrh4410.8GH1, PROP1, HESX1, HCRT
3quinagolide4410.8IGF1, PRL, GH1
4matrigel4410.8LGALS1, KRT8, KRT7, CTNNB1, BRAF
5ghrp4410.8IGF1, PRL, GH1
6pyridostigmine44 1111.7IGF1, PRL, GH1
7vitamin a44 11 2412.7MMP9, CTNNB1, RARB, KRT14, RARS
8hexarelin44 2811.7IGF1, PRL, GH1
9dopamine44 28 11 2413.7RARB, CTNNB1, IGF1, HCRT, MMP9
10acth4410.7PRL, IGF1, HCRT, PROP1, GH1, HESX1
11leuprolide acetate4410.7PRL, IGF1, GH1
12octreotide44 59 28 1113.7GH1, PRL, VEGFA, IGF1
13lanreotide44 2811.7IGF1, GH1, PRL
14hematoxylin4410.7MMP9, KRT14, KRT8, KRT7
15tamoxifen44 49 28 1113.7VEGFA, PRL, IGF1, GH1, CTNNB1, KRT14
16sb 20358044 5911.7BRAF, MMP9, IGF1, VEGFA, GH1, CTNNB1
17steroid4410.7GH1, PROP1, PRL, RARS, KRT8, RARB
18ribonucleic acid4410.7IGF1, HCRT, GH1, PRL, RARB, MMP9
19dexamethasone44 49 28 1113.7LGALS1, CTNNB1, GH1, VEGFA, HCRT, MMP9
20genistein44 28 59 2 11 2415.7VEGFA, KRT8, RARB, MMP9, IGF1, GH1
21vitamin d4410.7GH1, CTNNB1, IGF1, RARS, RARB, KRT14
22glucose4410.7IGF1, HCRT, KRT7, KRT8, LGALS1, KRT14
23clomiphene citrate4410.7IGF1, GH1, PRL
24actinomycin d4410.7MMP9, VEGFA, IGF1, RARB, KRT8, GH1
25naltrexone44 49 28 1113.7IGF1, GH1, PRL
26retinoid4410.6KRT8, GH1, RARS, RARB, KRT14, KRT7
27paraffin4410.6BRAF, GH1, VEGFA, MMP9, KRT14, KRT7
28agar4410.6KRT8, RARB, CTNNB1, BRAF, LGALS1
29vegf4410.6MMP9, BRAF, CTNNB1, GH1, VEGFA, IGF1
30serine4410.6PROP1, GH1, KRT14, KRT8, MMP9
31cabergoline28 44 1112.6PRL, IGF1, GH1
32chloramphenicol44 2 1112.6GH1, MMP9, RARS, RARB, KRT14
33progesterone44 59 28 11 2414.6CTNNB1, KRT8, KRT7, KRT14, RARB, RARS
34cysteine4410.6CTNNB1, MMP9, RARB, KRT8, LGALS1, RARS
35cisplatin44 49 59 1113.6VEGFA, KRT8, KRT14, RARB, CTNNB1, BRAF
36arginine4410.6GH1, BRAF, CTNNB1, PRL, IGF1, RARS
37retinoic acid44 2411.6KRT14, KRT7, MMP9, IGF1, GH1, CTNNB1
38isotretinoin44 1111.6KRT14, RARB, RARS
39testosterone44 59 11 2413.6KRT8, RARS, MMP9, HCRT, IGF1, PROP1
40hydrocortisone44 2 59 1113.6KRT14, PRL, IGF1, GH1
41cetuximab44 49 1112.5BRAF, CTNNB1, VEGFA
42tyrosine4410.5VEGFA, GH1, CTNNB1, LGALS1, IGF1, HCRT
43somatuline4410.5GH1, IGF1
44rapamycin4410.5BRAF, IGF1, CTNNB1, LGALS1, VEGFA
45lipid4410.5LGALS1, GH1, HCRT, RARB, KRT8, KRT14
46pd 98,0594410.4BRAF, GH1, IGF1, MMP9, CTNNB1
47ciglitazone44 2811.4RARB, MMP9, GH1
48ly2940024410.3IGF1, VEGFA, BRAF, CTNNB1, MMP9
49wortmannin4410.2MMP9, IGF1, BRAF, GH1, CTNNB1
50bromodeoxyuridine4410.1KRT14, KRT8, CTNNB1, RARS

GO Terms for genes affiliated with Craniopharyngioma

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16Gene Ontology
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Cellular components related to Craniopharyngioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.4KRT8, KRT7, KRT14
2secretory granuleGO:03014110.3HCRT, VEGFA, PRL
3keratin filamentGO:04509510.1KRT8, KRT7, KRT14

Biological processes related to Craniopharyngioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1myoblast differentiationGO:04544510.6LGALS1, IGF1, CTNNB1
2positive regulation of epithelial cell proliferationGO:05067910.5IGF1, VEGFA, PRL
3multicellular organismal response to stressGO:03355510.5LGALS1, PRL
4response to estradiol stimulusGO:03235510.5CTNNB1, GH1, PRL
5positive regulation of JAK-STAT cascadeGO:04642710.4PRL, GH1
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.4IGF1, VEGFA, GH1
7positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.3GH1, IGF1
8negative regulation of chondrocyte differentiationGO:03233110.1RARB, CTNNB1

Molecular functions related to Craniopharyngioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.4IGF1, PRL, GH1
2prolactin receptor bindingGO:00514810.1PRL, GH1
3protein bindingGO:0055159.9LGALS1, BRAF, HESX1, CTNNB1, GH1, PRL

Products for genes affiliated with Craniopharyngioma

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  • Antibodies
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Sources for Craniopharyngioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet