MCID: CRN036
MIFTS: 63

Craniopharyngioma malady

Rare diseases, Neuronal diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Craniopharyngioma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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Fully expand this MalaCard
NIH Rare Diseases:43 A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves). this tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected. craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum.[orphanet] craniopharyngioma is treated with surgery alone or by surgery followed by radiation. last updated: 4/3/2009

MalaCards: Craniopharyngioma, also known as dysodontogenic epithelial tumor, is related to obesity and pituitary adenoma. An important gene associated with Craniopharyngioma is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Thyroid cancer and Corticotropin-releasing hormone. The compounds somatuline and quinagolide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and hypothalamus, and related mouse phenotypes are hearing/vestibular/ear and adipose tissue.

Wikipedia:65 Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs... more...

Aliases & Classifications for Craniopharyngioma

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

49
craniopharyngioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

craniopharyngioma 8 43 10 45 49 62
dysodontogenic epithelial tumor 43
craniopharyngeal duct tumor 43
neoplasm of rathke's pouch 8
adamantinomatous tumor 43
rathke's pouch tumor 43


External Ids:

Disease Ontology8 DOID:3840
MeSH35 D003397
NCIt40 C2964
MESH via Orphanet36 D003397
SNOMED-CT58 40009002, 189179009
ICD10 via Orphanet26 D44.4
SNOMED-CT via Orphanet59 189179009, 40009002
UMLS via Orphanet63 C0010276

Related Diseases for Craniopharyngioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Craniopharyngioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1obesity31.0HCRT, GH1, PROP1, IGF1
2pituitary adenoma30.7GH1, IGF1, PRL, PROP1
3adenoma30.5GH1, RARB, KRT14, KRT8, CTNNB1, IGF1
4panhypopituitarism30.4PROP1, GH1, PRL, IGF1
5precocious puberty30.2GH1, PRL, IGF1
6hypopituitarism30.2GH1, IGF1, PROP1, PRL
7chordoma30.2KRT14, KRT8
8chromophobe adenoma30.2GH1, PRL
9growth hormone deficiency30.1GH1, PROP1, IGF1, PRL
10pituitary tumors30.1IGF1, PRL, PROP1, GH1
11diabetes mellitus30.0GH1, MMP9, VEGFA, IGF1
12turner syndrome30.0IGF1
13prader-willi syndrome29.9GH1, HCRT, IGF1
14hemangioblastoma29.9VEGFA, KRT8
15cholesteatoma29.9KRT14, MMP9, RARB
16acromegaly29.9GH1, IGF1, PRL
17prolactinoma29.9GH1, PRL, IGF1
18hyperthyroidism29.9IGF1, PRL, GH1
19hypogonadism29.8PRL, GH1, PROP1, IGF1
20anorexia nervosa29.8GH1, IGF1, PRL, HCRT
21hypoglycemia29.8HCRT, PRL, GH1, IGF1
22melanoma29.6VEGFA, MMP9, RARB, KRT14, CTNNB1, HCRT
23papillary craniopharyngioma10.4
24cerebritis10.2
25adamantinous craniopharyngioma10.2
26diabetes insipidus10.2
27astrocytoma10.2
28germ cell tumors10.2
29pituitary hypoplasia10.1PROP1
30meningioma10.1
31meningitis10.1
32gardner syndrome10.1
33endotheliitis10.1
34rabson-mendenhall syndrome10.1IGF1
35pituitary apoplexy10.1PRL
36septo-optic dysplasia10.1GH1, PROP1
37insulin-like growth factor 1 resistance to10.1IGF1, GH1
38gonadal disease10.1IGF1, GH1
39idiopathic juvenile osteoporosis10.1GH1, IGF1
40colorectal cancer10.1BRAF, CTNNB1
41laron syndrome10.1GH1, IGF1
42angiosarcoma10.1KRT14, KRT8
43growth retardation-mild developmental delay-chronic hepatitis syndrome10.1IGF1, GH1
44breast fibroadenoma10.1KRT14, KRT8
45cervical squamous cell carcinoma10.1KRT14, KRT8
46synovial sarcoma10.1KRT8, KRT14, CTNNB1
47adenoameloblastoma10.1KRT8, KRT14
48mccune albright syndrome10.1PRL, GH1
49leukoplakia10.1RARB, KRT8
50hypothalamic disease10.1GH1, PRL

Graphical network of the top 20 diseases related to Craniopharyngioma:



Diseases related to craniopharyngioma

Symptoms for Craniopharyngioma

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Drugs & Therapeutics for Craniopharyngioma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Craniopharyngioma

Search NIH Clinical Center for Craniopharyngioma

Genetic Tests for Craniopharyngioma

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Anatomical Context for Craniopharyngioma

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33MalaCards
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MalaCards organs/tissues related to Craniopharyngioma:

33
Pituitary, Brain, Hypothalamus, Bone, Endothelial, Skin, Testes, Temporal lobe

Animal Models for Craniopharyngioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Craniopharyngioma:

37 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9IGF1, RARB, KRT14, CTNNB1
2MP:00053758.8IGF1, BRAF, GH1, KRT14
3MP:00053808.3CTNNB1, KRT8, RARB, BRAF, VEGFA
4MP:00053718.1IGF1, VEGFA, MMP9, RARB, CTNNB1
5MP:00053828.1VEGFA, BRAF, RARB, KRT14, ENAM, CTNNB1
6MP:00053708.0VEGFA, BRAF, PRL, GH1, KRT8, CTNNB1
7MP:00053918.0VEGFA, BRAF, MMP9, RARB, KRT14, CTNNB1
8MP:00053677.9IGF1, VEGFA, BRAF, MMP9, RARB, CTNNB1
9MP:00053907.8IGF1, VEGFA, BRAF, MMP9, RARB, CTNNB1
10MP:00053817.8VEGFA, BRAF, MMP9, RARB, KRT8, KRT14
11MP:00053697.7IGF1, HCRT, VEGFA, BRAF, MMP9, RARB
12MP:00053847.6IGF1, VEGFA, BRAF, MMP9, PROP1, KRT14
13MP:00020067.6IGF1, VEGFA, BRAF, MMP9, PRL, KRT14
14MP:00107717.5IGF1, VEGFA, BRAF, MMP9, PRL, KRT14
15MP:00053857.4IGF1, HCRT, VEGFA, BRAF, MMP9, RARB
16MP:00053977.3IGF1, VEGFA, BRAF, MMP9, RARB, KRT8
17MP:00053797.3IGF1, VEGFA, BRAF, PRL, PROP1, GH1
18MP:00053867.2HCRT, VEGFA, BRAF, MMP9, PRL, PROP1
19MP:00053887.2IGF1, HCRT, VEGFA, BRAF, MMP9, PROP1
20MP:00107687.0IGF1, VEGFA, BRAF, MMP9, PROP1, RARB
21MP:00053876.8IGF1, VEGFA, BRAF, MMP9, PRL, RARB
22MP:00036316.5BRAF, VEGFA, HCRT, IGF1, MMP9, PRL
23MP:00053786.5IGF1, HCRT, VEGFA, BRAF, MMP9, PROP1
24MP:00053896.2CTNNB1, IGF1, VEGFA, BRAF, MMP9, PRL
25MP:00053766.1BRAF, VEGFA, HCRT, IGF1, MMP9, PRL

Publications for Craniopharyngioma

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Sources:
52PubMed
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Articles related to Craniopharyngioma:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Congenital giant craniopharyngioma. (22983633)
2013
2
Glioblastoma occurring after the surgical resection of a craniopharyngioma. (24011139)
2013
3
SECONDARY NEUTRON DOSES IN PROTON THERAPY TREATMENTS OF OCULAR MELANOMA AND CRANIOPHARYNGIOMA. (24222710)
2013
4
Recurrent depressive illness or craniopharyngioma: a diagnostic dilemma. (23913493)
2013
5
Initial visual field as a predictor of recurrence and postoperative visual outcome in children with craniopharyngioma. (21323242)
2012
6
Stereotactic neurosurgical treatment options for craniopharyngioma. (22654877)
2012
7
Endoscopic endonasal craniopharyngioma resection. (22251253)
2012
8
Craniopharyngioma. (22920293)
2012
9
Delayed ghrelin suppression following oral glucose tolerance test in children and adolescents with hypothalamic injury secondary to craniopharyngioma compared with obese controls. (21050078)
2011
10
Primary cerebellopontine angle craniopharyngioma in a patient with Gardner syndrome. (21216148)
2011
11
Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma. (20535527)
2011
12
Consequences of craniopharyngioma surgery in children. (21508127)
2011
13
EGFR signaling regulates tumor cell migration in craniopharyngiomas. (21562037)
2011
14
Post-operative implantation metastasis of craniopharyngioma: a case report. (21309505)
2010
15
Expression of aberrant beta-catenin and impaired p63 in craniopharyngiomas. (20128632)
2010
16
Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases. (20121363)
2010
17
Antenatal diagnosis of the congenital craniopharyngioma. (22802769)
2010
18
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
19
Childhood craniopharyngioma: greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index. (19341477)
2009
20
Predicting behavioral problems in craniopharyngioma survivors after conformal radiation therapy. (19191345)
2009
21
Craniopharyngioma causing visual loss in an adult. (19062468)
2008
22
Collision lesions of the sella: co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke's cleft cyst with corticotroph adenoma. (17917812)
2008
23
'Do no harm': management of craniopharyngioma. (18775978)
2008
24
Asymptomatic spontaneous rupture of craniopharyngioma cyst. (18329880)
2008
25
Entire infrasellar craniopharyngioma simulating clival chordoma. (18036439)
2007
26
Extracranial nasopharyngeal craniopharyngioma: case report. (17415187)
2007
27
Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. (17410335)
2007
28
Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis]. (17294730)
2007
29
Successfully treated acute lymphoblastic leukemia associated with craniopharyngioma. (17551406)
2007
30
The spectrum of malignancy in craniopharyngioma. (17592268)
2007
31
Craniopharyngioma: modern concepts in pathogenesis and treatment. (17630614)
2007
32
Recurrent infrasellar clival craniopharyngioma. (17533510)
2007
33
The craniopharyngioma. (16474218)
2006
34
Everyday cognitive function after craniopharyngioma in childhood. (16376272)
2006
35
Relapse pattern after complete resection and early progression after incomplete resection of childhood craniopharyngioma. (17080333)
2006
36
Warfarin induced skin necrosis in a patient with craniopharyngioma. (22266504)
2006
37
Uncommon presentation of craniopharyngioma with anemia in an adolescent. (16047369)
2006
38
Prenatal diagnosis of a craniopharyngioma: a new case with radical surgery and review. (15290187)
2005
39
Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst. (15716233)
2005
40
Cranial base strategies for resection of craniopharyngioma in children. (16048295)
2005
41
Acute and fatal hyponatraemia after resection of a craniopharyngioma: a preventable tragedy. (16055476)
2005
42
Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas. (15043773)
2004
43
Transsphenoidal microsurgery for pediatric craniopharyngioma: special considerations regarding indications and method. (12845200)
2003
44
Stereotactic radiosurgery. XVII: Recurrent intrasellar craniopharyngioma. (12820755)
2003
45
Ectopic clival craniopharyngioma. (12434179)
2002
46
Precocious puberty associated with growth hormone deficiency in a patient with craniopharyngioma: report of one case. (11550415)
2001
47
Treatment of sodium disorders after surgery of craniopharyngioma. (12906149)
2000
48
Malignant transformation of craniopharyngioma. (18639199)
1999
49
Craniopharyngioma: endocrine sequelae of treatment. (7841071)
1994
50
Craniopharyngioma with panhypopituitarism; case report with clinical and pathological study. (20288018)
1946

Variations for Craniopharyngioma

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Expression for genes affiliated with Craniopharyngioma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Craniopharyngioma

Search GEO for disease gene expression data for Craniopharyngioma.

Pathways for genes affiliated with Craniopharyngioma

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome, 5Cell Signaling Technology, 51PharmGKB
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Pathways related to Craniopharyngioma according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CTNNB1, BRAF
29.6BRAF, KRT14, CTNNB1
3
Show member pathways
Signal transduction PTEN pathway60
9.5IGF1, BRAF, CTNNB1
49.5CTNNB1, BRAF, IGF1
59.5GH1, PRL
6
Show member pathways
9.5GH1, PRL
79.4CTNNB1, GH1, IGF1
8
Show member pathways
9.4IGF1, GH1, CTNNB1
99.4BRAF, MMP9, CTNNB1
10
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.4BRAF, VEGFA
11
Show member pathways
9.3GH1, MMP9, BRAF
12
Show member pathways
9.2IGF1, BRAF, GH1, CTNNB1
13
Show member pathways
9.2CTNNB1, GH1, BRAF, IGF1
14
Show member pathways
Angiogenesis38
9.1MMP9, VEGFA
159.1CTNNB1, BRAF, VEGFA
169.0CTNNB1, VEGFA, IGF1
17
Show member pathways
9.0MMP9, PRL, GH1
18
Show member pathways
8.9GH1, MMP9, BRAF, IGF1
198.9CTNNB1, MMP9, VEGFA
20
Show member pathways
8.8IGF1, BRAF, PRL, GH1
21
Show member pathways
8.8GH1, PRL, BRAF, IGF1
22
Show member pathways
8.7CTNNB1, BRAF, VEGFA, IGF1
23
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.7IGF1, VEGFA, BRAF, CTNNB1
24
Show member pathways
8.7IGF1, BRAF, GH1, RARB, CTNNB1
258.5IGF1, VEGFA, RARB, CTNNB1
26
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.5IGF1, VEGFA, MMP9, CTNNB1
27
Show member pathways
8.4IGF1, BRAF, MMP9, GH1, RARB
288.3IGF1, VEGFA, MMP9, GH1
298.2IGF1, VEGFA, PRL, GH1
308.2IGF1, VEGFA, BRAF, MMP9, CTNNB1
31
Show member pathways
7.9RARB, GH1, PRL, BRAF, VEGFA
32
Show member pathways
Signaling Pathways in Glioblastoma38
7.7CTNNB1, RARB, MMP9, BRAF, VEGFA, IGF1
337.7IGF1, VEGFA, BRAF, MMP9, RARB, CTNNB1
34
Show member pathways
6.9IGF1, HCRT, VEGFA, BRAF, MMP9, PRL

Compounds for genes affiliated with Craniopharyngioma

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 3BitterDB, 61Tocris Bioscience, 24HMDB
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Compounds related to Craniopharyngioma according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1somatuline459.7GH1, IGF1
2quinagolide459.5GH1, PRL, IGF1
3ghrp459.4PRL, GH1, IGF1
4pyridostigmine45 1110.4IGF1, PRL, GH1
5hexarelin45 2910.4GH1, PRL, IGF1
6lanreotide45 2910.4PRL, IGF1, GH1
7leuprolide acetate459.4IGF1, PRL, GH1
8clomiphene citrate459.4GH1, IGF1, PRL
9naltrexone45 29 51 1112.3IGF1, PRL, GH1
10cabergoline45 29 1111.3IGF1, PRL, GH1
11cetuximab45 51 1111.2CTNNB1, BRAF, VEGFA
12ciglitazone45 2910.1MMP9, GH1, RARB
13retinoid459.1KRT14, KRT8, GH1, CTNNB1, RARB
14hydrocortisone45 3 61 1112.0PRL, IGF1, KRT14, GH1
15vitamin d459.0GH1, KRT14, CTNNB1, IGF1, RARB
16dihydrotestosterone45 29 24 1112.0GH1, IGF1, PRL, CTNNB1
17pd 98,059459.0CTNNB1, MMP9, BRAF, IGF1, GH1
18wortmannin458.9IGF1, CTNNB1, GH1, BRAF, MMP9
19thyroxine45 249.9IGF1, GH1, PRL, HCRT
20acth458.9HCRT, PRL, PROP1, IGF1, GH1
21oligonucleotide458.8KRT8, RARB, HCRT, GH1, BRAF, CTNNB1
22gnrh458.7GH1, IGF1, PROP1, PRL, HCRT, CTNNB1
23octreotide45 61 29 1111.6PRL, GH1, IGF1, VEGFA
24matrigel458.6VEGFA, KRT8, MMP9, BRAF, CTNNB1
25egcg458.6MMP9, RARB, VEGFA, CTNNB1
26vitamin a45 24 1110.6MMP9, RARB, KRT14, CTNNB1
27alanine458.6HCRT, BRAF, MMP9, GH1, CTNNB1, KRT14
28estradiol45 24 1110.6GH1, PRL, RARB, HCRT, IGF1
29ly294002458.5BRAF, CTNNB1, IGF1, VEGFA, MMP9
30cisplatin45 51 61 1111.4BRAF, CTNNB1, KRT14, VEGFA, KRT8, RARB
31sb 20358045 619.2CTNNB1, MMP9, BRAF, IGF1, VEGFA, GH1
32ribonucleic acid458.2IGF1, PRL, HCRT, MMP9, GH1, RARB
33glucose458.2KRT14, GH1, PRL, BRAF, HCRT, IGF1
34arginine458.2KRT14, GH1, CTNNB1, PRL, BRAF, IGF1
35steroid458.1GH1, PROP1, KRT8, RARB, PRL, IGF1
36cysteine458.1CTNNB1, MMP9, GH1, RARB, KRT14, KRT8
37serine458.1CTNNB1, MMP9, BRAF, GH1, KRT8, IGF1
38paraffin458.0KRT14, KRT8, GH1, MMP9, BRAF, VEGFA
39dopamine45 29 24 1111.0CTNNB1, RARB, PRL, HCRT, GH1, IGF1
40actinomycin d458.0RARB, KRT8, MMP9, VEGFA, IGF1, GH1
41retinoic acid45 248.9GH1, RARB, KRT8, CTNNB1, MMP9, KRT14
42vegf457.9GH1, CTNNB1, BRAF, VEGFA, IGF1, MMP9
43progesterone45 29 61 24 1111.9KRT14, CTNNB1, IGF1, PRL, BRAF, KRT8
44tamoxifen45 51 29 1110.8IGF1, KRT8, KRT14, GH1, PRL, VEGFA
45genistein45 29 61 3 24 1112.7CTNNB1, RARB, KRT8, GH1, MMP9, VEGFA
46cycloheximide457.7IGF1, KRT8, CTNNB1, RARB, VEGFA, GH1
47testosterone45 61 24 1110.4IGF1, HCRT, MMP9, PROP1, GH1, RARB
48dexamethasone45 51 29 1110.2GH1, RARB, CTNNB1, PRL, MMP9, VEGFA
49tyrosine456.8HCRT, VEGFA, BRAF, MMP9, GH1, RARB
50estrogen456.2KRT14, HCRT, BRAF, MMP9, PRL, GH1

GO Terms for genes affiliated with Craniopharyngioma

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Sources:
16Gene Ontology
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Cellular components related to Craniopharyngioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell peripheryGO:0719449.6CTNNB1, KRT14
2proteinaceous extracellular matrixGO:0055788.6ENAM, MMP9, VEGFA
3extracellular regionGO:0055767.3GH1, IGF1, HCRT, VEGFA, MMP9, PRL

Biological processes related to Craniopharyngioma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1myoblast differentiationGO:04544510.1IGF1, CTNNB1
2regulation of myelinationGO:03164110.1RARB, CTNNB1
3negative regulation of chondrocyte differentiationGO:03233110.0CTNNB1, RARB
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0GH1, IGF1
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9GH1, IGF1
6embryonic hindlimb morphogenesisGO:0351169.8RARB, CTNNB1
7positive regulation of JAK-STAT cascadeGO:0464279.8PRL, GH1
8JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7GH1, PRL
9positive regulation of neuroblast proliferationGO:0020529.6VEGFA, CTNNB1
10regulation of multicellular organism growthGO:0400149.6IGF1, PRL
11positive regulation of receptor internalizationGO:0020929.5VEGFA, GH1
12macrophage differentiationGO:0302259.4VEGFA, MMP9
13positive regulation of mesenchymal cell proliferationGO:0020539.4CTNNB1, VEGFA
14branching morphogenesis of an epithelial tubeGO:0487549.4VEGFA, IGF1
15patterning of blood vesselsGO:0015699.3CTNNB1, VEGFA
16positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2IGF1, VEGFA, GH1
17cell maturationGO:0484699.1VEGFA, CTNNB1
18lactationGO:0075959.0VEGFA, PRL
19negative regulation of transcription from RNA polymerase II promoterGO:0001228.9CTNNB1, VEGFA, PROP1, RARB
20positive regulation of transcription from RNA polymerase II promoterGO:0459448.6RARB, PROP1, VEGFA, IGF1, CTNNB1

Molecular functions related to Craniopharyngioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.5GH1, PRL
2protein complex bindingGO:0324039.4CTNNB1, KRT8, RARB
3hormone activityGO:0051799.0IGF1, PRL, GH1
4growth factor activityGO:0080838.6IGF1, VEGFA, GH1
5protein bindingGO:0055155.9PRL, GH1, RARB, KRT8, KRT14, CTNNB1

Products for genes affiliated with Craniopharyngioma

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  • Antibodies
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Sources for Craniopharyngioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet