MCID: CRN036
MIFTS: 54

Craniopharyngioma malady

Rare diseases, Neuronal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Craniopharyngioma

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NIH Rare Diseases:41 A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves). this tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected. craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum.[orphanet] craniopharyngioma is treated with surgery alone or by surgery followed by radiation. last updated: 4/3/2009

MalaCards based summary: Craniopharyngioma, also known as dysodontogenic epithelial tumor, is related to obesity and pituitary adenoma. An important gene associated with Craniopharyngioma is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Thyroid cancer and Corticotropin-releasing hormone. The compounds somatuline and quinagolide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and hypothalamus, and related mouse phenotypes are hearing/vestibular/ear and adipose tissue.

Wikipedia:63 Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs... more...

Aliases & Classifications for Craniopharyngioma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Craniopharyngioma, Aliases & Descriptions:

Name: Craniopharyngioma 9 41 11 43 47 60
Dysodontogenic Epithelial Tumor 41
Craniopharyngeal Duct Tumor 41
 
Neoplasm of Rathke's Pouch 9
Adamantinomatous Tumor 41
Rathke's Pouch Tumor 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

47
craniopharyngioma:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/1000000 (United States); Age of onset: All ages


External Ids:

Disease Ontology9 DOID:3840
MeSH33 D003397
NCIt38 C2964
Orphanet47 54595
SNOMED-CT55 189179009, 40009002
MESH via Orphanet34 D003397
ICD10 via Orphanet26 D44.4
UMLS via Orphanet61 C0010276

Related Diseases for Craniopharyngioma

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Diseases related to Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1obesity31.1HCRT, GH1, PROP1, IGF1
2pituitary adenoma30.7GH1, IGF1, PRL, PROP1
3chordoma30.6KRT14, KRT8
4chromophobe adenoma30.5GH1, PRL
5turner syndrome30.5IGF1
6precocious puberty30.4GH1, PRL, IGF1
7ameloblastoma30.3KRT8, KRT14
8hypopituitarism30.3GH1, IGF1, PROP1, PRL
9prader-willi syndrome30.2GH1, HCRT, IGF1
10hemangioblastoma30.1VEGFA, KRT8
11growth hormone deficiency30.1GH1, PROP1, IGF1, PRL
12pituitary tumors30.1IGF1, PRL, PROP1, GH1
13cholesteatoma30.1KRT14, MMP9, RARB
14acromegaly30.0GH1, IGF1, PRL
15prolactinoma30.0GH1, PRL, IGF1
16hyperthyroidism30.0IGF1, PRL, GH1
17hypogonadism29.9PRL, GH1, PROP1, IGF1
18anorexia nervosa29.9GH1, IGF1, PRL, HCRT
19hypoglycemia29.9HCRT, PRL, GH1, IGF1
20adenoma29.6GH1, RARB, KRT14, KRT8, CTNNB1, IGF1
21melanoma28.8VEGFA, MMP9, RARB, KRT14, CTNNB1, HCRT
22pituitary hypoplasia10.6PROP1
23papillary craniopharyngioma10.5
24rabson-mendenhall syndrome10.5IGF1
25pituitary apoplexy10.4PRL
26septooptic dysplasia10.4GH1, PROP1
27insulin-like growth factor 1 resistance to10.3IGF1, GH1
28gonadal disease10.3IGF1, GH1
29idiopathic juvenile osteoporosis10.3GH1, IGF1
30colorectal cancer10.3BRAF, CTNNB1
31laron dwarfism10.3GH1, IGF1
32angiosarcoma10.3KRT14, KRT8
33breast fibroadenoma10.3KRT14, KRT8
34cervical squamous cell carcinoma10.3KRT14, KRT8
35cerebritis10.3
36adamantinous craniopharyngioma10.3
37sarcoma, synovial10.3KRT8, KRT14, CTNNB1
38mccune-albright syndrome, somatic, mosaic10.3PRL, GH1
39leukoplakia10.3RARB, KRT8
40hypothalamic disease10.3GH1, PRL
41pituitary-dependent cushing's disease10.3PRL, GH1
42sheehan syndrome10.3PRL, IGF1
43oligomenorrhea10.3PRL, GH1
44prostatic hypertrophy10.3GH1, PRL
45diabetes insipidus10.3
46oxyphilic adenoma10.2KRT8, KRT14, GH1
47dwarfism10.2IGF1, GH1, PROP1
48anovulation10.2PRL, IGF1
49adrenal gland hyperfunction10.2PRL, GH1
50amenorrhea10.2IGF1, PRL

Graphical network of the top 20 diseases related to Craniopharyngioma:



Diseases related to craniopharyngioma

Symptoms for Craniopharyngioma

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Drugs & Therapeutics for Craniopharyngioma

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Drug clinical trials:

Search ClinicalTrials for Craniopharyngioma

Search NIH Clinical Center for Craniopharyngioma

Genetic Tests for Craniopharyngioma

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Anatomical Context for Craniopharyngioma

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MalaCards organs/tissues related to Craniopharyngioma:

31
Pituitary, Brain, Hypothalamus, Bone, Endothelial, Skin, Testes, Temporal lobe

Animal Models for Craniopharyngioma or affiliated genes

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MGI Mouse Phenotypes related to Craniopharyngioma:

35 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9IGF1, RARB, KRT14, CTNNB1
2MP:00053758.8IGF1, BRAF, GH1, KRT14
3MP:00053808.3CTNNB1, KRT8, RARB, BRAF, VEGFA
4MP:00053718.1IGF1, VEGFA, MMP9, RARB, CTNNB1
5MP:00053828.1VEGFA, BRAF, RARB, KRT14, ENAM, CTNNB1
6MP:00053708.0VEGFA, BRAF, PRL, GH1, KRT8, CTNNB1
7MP:00053918.0VEGFA, BRAF, MMP9, RARB, KRT14, CTNNB1
8MP:00053677.9IGF1, VEGFA, BRAF, MMP9, RARB, CTNNB1
9MP:00053907.8IGF1, VEGFA, BRAF, MMP9, RARB, CTNNB1
10MP:00053817.8VEGFA, BRAF, MMP9, RARB, KRT8, KRT14
11MP:00053697.7IGF1, HCRT, VEGFA, BRAF, MMP9, RARB
12MP:00053847.6IGF1, VEGFA, BRAF, MMP9, PROP1, KRT14
13MP:00020067.6IGF1, VEGFA, BRAF, MMP9, PRL, KRT14
14MP:00107717.5IGF1, VEGFA, BRAF, MMP9, PRL, KRT14
15MP:00053857.4IGF1, HCRT, VEGFA, BRAF, MMP9, RARB
16MP:00053977.3IGF1, VEGFA, BRAF, MMP9, RARB, KRT8
17MP:00053797.3IGF1, VEGFA, BRAF, PRL, PROP1, GH1
18MP:00053867.2HCRT, VEGFA, BRAF, MMP9, PRL, PROP1
19MP:00053887.2IGF1, HCRT, VEGFA, BRAF, MMP9, PROP1
20MP:00107687.0IGF1, VEGFA, BRAF, MMP9, PROP1, RARB
21MP:00053876.8IGF1, VEGFA, BRAF, MMP9, PRL, RARB
22MP:00036316.5BRAF, VEGFA, HCRT, IGF1, MMP9, PRL
23MP:00053786.5IGF1, HCRT, VEGFA, BRAF, MMP9, PROP1
24MP:00053896.2CTNNB1, IGF1, VEGFA, BRAF, MMP9, PRL
25MP:00053766.1BRAF, VEGFA, HCRT, IGF1, MMP9, PRL

Publications for Craniopharyngioma

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Articles related to Craniopharyngioma:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Recurrent craniopharyngioma after conformal radiation in children and the burden of treatment. (25700121)
2015
2
An Infrasellar Craniopharyngioma Involving the Sphenoid Sinus and Clivus. (25758284)
2015
3
Excess mortality and morbidity in patients with craniopharyngioma, especially in patients with childhood-onset - a population-based study in Sweden. (25375987)
2014
4
From cerebral salt wasting to diabetes insipidus with adipsia: case report of a child with craniopharyngioma. (25210759)
2014
5
Endovascular Treatment for Fusiform Dilation of Internal Carotid Artery Following Craniopharyngioma Resection: A Case Illustration. (25316730)
2014
6
Primary intracranial ectopic craniopharyngioma in a patient with probable Gardner's syndrome. (24266539)
2013
7
Congenital giant craniopharyngioma. (22983633)
2013
8
Glioblastoma occurring after the surgical resection of a craniopharyngioma. (24011139)
2013
9
SECONDARY NEUTRON DOSES IN PROTON THERAPY TREATMENTS OF OCULAR MELANOMA AND CRANIOPHARYNGIOMA. (24222710)
2013
10
Recurrent depressive illness or craniopharyngioma: a diagnostic dilemma. (23913493)
2013
11
Initial visual field as a predictor of recurrence and postoperative visual outcome in children with craniopharyngioma. (21323242)
2012
12
Stereotactic neurosurgical treatment options for craniopharyngioma. (22654877)
2012
13
Endoscopic endonasal craniopharyngioma resection. (22251253)
2012
14
Craniopharyngioma. (22920293)
2012
15
Delayed ghrelin suppression following oral glucose tolerance test in children and adolescents with hypothalamic injury secondary to craniopharyngioma compared with obese controls. (21050078)
2011
16
Primary cerebellopontine angle craniopharyngioma in a patient with Gardner syndrome. (21216148)
2011
17
Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma. (20535527)
2011
18
Consequences of craniopharyngioma surgery in children. (21508127)
2011
19
EGFR signaling regulates tumor cell migration in craniopharyngiomas. (21562037)
2011
20
Post-operative implantation metastasis of craniopharyngioma: a case report. (21309505)
2010
21
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
22
Childhood craniopharyngioma: greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index. (19341477)
2009
23
Predicting behavioral problems in craniopharyngioma survivors after conformal radiation therapy. (19191345)
2009
24
Craniopharyngioma causing visual loss in an adult. (19062468)
2008
25
Collision lesions of the sella: co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke's cleft cyst with corticotroph adenoma. (17917812)
2008
26
'Do no harm': management of craniopharyngioma. (18775978)
2008
27
Asymptomatic spontaneous rupture of craniopharyngioma cyst. (18329880)
2008
28
Entire infrasellar craniopharyngioma simulating clival chordoma. (18036439)
2007
29
Extracranial nasopharyngeal craniopharyngioma: case report. (17415187)
2007
30
Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. (17410335)
2007
31
Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis]. (17294730)
2007
32
Successfully treated acute lymphoblastic leukemia associated with craniopharyngioma. (17551406)
2007
33
The spectrum of malignancy in craniopharyngioma. (17592268)
2007
34
Craniopharyngioma: modern concepts in pathogenesis and treatment. (17630614)
2007
35
The craniopharyngioma. (16474218)
2006
36
Everyday cognitive function after craniopharyngioma in childhood. (16376272)
2006
37
Relapse pattern after complete resection and early progression after incomplete resection of childhood craniopharyngioma. (17080333)
2006
38
Warfarin induced skin necrosis in a patient with craniopharyngioma. (22266504)
2006
39
Prenatal diagnosis of a craniopharyngioma: a new case with radical surgery and review. (15290187)
2005
40
Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst. (15716233)
2005
41
Cranial base strategies for resection of craniopharyngioma in children. (16048295)
2005
42
Acute and fatal hyponatraemia after resection of a craniopharyngioma: a preventable tragedy. (16055476)
2005
43
Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas. (15043773)
2004
44
Transsphenoidal microsurgery for pediatric craniopharyngioma: special considerations regarding indications and method. (12845200)
2003
45
Stereotactic radiosurgery. XVII: Recurrent intrasellar craniopharyngioma. (12820755)
2003
46
Ectopic clival craniopharyngioma. (12434179)
2002
47
Precocious puberty associated with growth hormone deficiency in a patient with craniopharyngioma: report of one case. (11550415)
2001
48
Treatment of sodium disorders after surgery of craniopharyngioma. (12906149)
2000
49
Malignant transformation of craniopharyngioma. (18639199)
1999
50
Craniopharyngioma: endocrine sequelae of treatment. (7841071)
1994

Variations for Craniopharyngioma

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Cosmic variations for Craniopharyngioma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
15686CTNNB1pituitary,craniopharyngeal duct,craniopharyngioma,NS3
25670CTNNB1pituitary,craniopharyngeal duct,craniopharyngioma,NS3
35661CTNNB1pituitary,craniopharyngeal duct,craniopharyngioma,NS3

Expression for genes affiliated with Craniopharyngioma

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Search GEO for disease gene expression data for Craniopharyngioma.

Pathways for genes affiliated with Craniopharyngioma

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Pathways related to Craniopharyngioma according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CTNNB1, BRAF
29.6BRAF, KRT14, CTNNB1
3
Show member pathways
Signal transduction PTEN pathway58
9.5IGF1, BRAF, CTNNB1
49.5CTNNB1, BRAF, IGF1
59.5GH1, PRL
6
Show member pathways
9.5GH1, PRL
79.4CTNNB1, GH1, IGF1
8
Show member pathways
9.4IGF1, GH1, CTNNB1
99.4BRAF, MMP9, CTNNB1
10
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.4BRAF, VEGFA
11
Show member pathways
9.3GH1, MMP9, BRAF
12
Show member pathways
9.2IGF1, BRAF, GH1, CTNNB1
13
Show member pathways
9.2CTNNB1, GH1, BRAF, IGF1
14
Show member pathways
Angiogenesis36
9.1MMP9, VEGFA
159.1CTNNB1, BRAF, VEGFA
169.0CTNNB1, VEGFA, IGF1
17
Show member pathways
9.0MMP9, PRL, GH1
18
Show member pathways
8.9GH1, MMP9, BRAF, IGF1
198.9CTNNB1, MMP9, VEGFA
20
Show member pathways
8.8IGF1, BRAF, PRL, GH1
21
Show member pathways
8.8GH1, PRL, BRAF, IGF1
22
Show member pathways
8.7CTNNB1, BRAF, VEGFA, IGF1
23
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.7IGF1, VEGFA, BRAF, CTNNB1
24
Show member pathways
8.7IGF1, BRAF, GH1, RARB, CTNNB1
258.5IGF1, VEGFA, RARB, CTNNB1
26
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.5IGF1, VEGFA, MMP9, CTNNB1
27
Show member pathways
8.4IGF1, BRAF, MMP9, GH1, RARB
288.3IGF1, VEGFA, MMP9, GH1
298.2IGF1, VEGFA, PRL, GH1
308.2IGF1, VEGFA, BRAF, MMP9, CTNNB1
31
Show member pathways
7.9RARB, GH1, PRL, BRAF, VEGFA
32
Show member pathways
Signaling Pathways in Glioblastoma36
7.7CTNNB1, RARB, MMP9, BRAF, VEGFA, IGF1
337.7IGF1, VEGFA, BRAF, MMP9, RARB, CTNNB1
34
Show member pathways
6.9IGF1, HCRT, VEGFA, BRAF, MMP9, PRL

Compounds for genes affiliated with Craniopharyngioma

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Compounds related to Craniopharyngioma according to GeneCards Suite gene sharing:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1somatuline439.7GH1, IGF1
2quinagolide439.5GH1, PRL, IGF1
3ghrp439.4PRL, GH1, IGF1
4pyridostigmine43 1210.4IGF1, PRL, GH1
5hexarelin43 2810.4GH1, PRL, IGF1
6lanreotide43 2810.4PRL, IGF1, GH1
7leuprolide acetate439.4IGF1, PRL, GH1
8clomiphene citrate439.4GH1, IGF1, PRL
9naltrexone43 28 49 1212.3IGF1, PRL, GH1
10cabergoline43 28 1211.3IGF1, PRL, GH1
11cetuximab43 49 1211.2CTNNB1, BRAF, VEGFA
12ciglitazone43 2810.1MMP9, GH1, RARB
13retinoid439.1KRT14, KRT8, GH1, CTNNB1, RARB
14hydrocortisone43 2 59 1212.0PRL, IGF1, KRT14, GH1
15vitamin d439.0GH1, KRT14, CTNNB1, IGF1, RARB
16dihydrotestosterone43 28 24 1212.0GH1, IGF1, PRL, CTNNB1
17pd 98,059439.0CTNNB1, MMP9, BRAF, IGF1, GH1
18wortmannin438.9IGF1, CTNNB1, GH1, BRAF, MMP9
19thyroxine43 249.9IGF1, GH1, PRL, HCRT
20acth438.9HCRT, PRL, PROP1, IGF1, GH1
21oligonucleotide438.8KRT8, RARB, HCRT, GH1, BRAF, CTNNB1
22gnrh438.7GH1, IGF1, PROP1, PRL, HCRT, CTNNB1
23octreotide43 59 28 1211.6PRL, GH1, IGF1, VEGFA
24matrigel438.6VEGFA, KRT8, MMP9, BRAF, CTNNB1
25egcg438.6MMP9, RARB, VEGFA, CTNNB1
26vitamin a43 24 1210.6MMP9, RARB, KRT14, CTNNB1
27alanine438.6HCRT, BRAF, MMP9, GH1, CTNNB1, KRT14
28estradiol43 24 1210.6GH1, PRL, RARB, HCRT, IGF1
29ly294002438.5BRAF, CTNNB1, IGF1, VEGFA, MMP9
30cisplatin43 49 59 1211.4BRAF, CTNNB1, KRT14, VEGFA, KRT8, RARB
31sb 20358043 599.2CTNNB1, MMP9, BRAF, IGF1, VEGFA, GH1
32ribonucleic acid438.2IGF1, PRL, HCRT, MMP9, GH1, RARB
33glucose438.2KRT14, GH1, PRL, BRAF, HCRT, IGF1
34arginine438.2KRT14, GH1, CTNNB1, PRL, BRAF, IGF1
35steroid438.1GH1, PROP1, KRT8, RARB, PRL, IGF1
36cysteine438.1CTNNB1, MMP9, GH1, RARB, KRT14, KRT8
37serine438.1CTNNB1, MMP9, BRAF, GH1, KRT8, IGF1
38paraffin438.0KRT14, KRT8, GH1, MMP9, BRAF, VEGFA
39dopamine43 28 24 1211.0CTNNB1, RARB, PRL, HCRT, GH1, IGF1
40actinomycin d438.0RARB, KRT8, MMP9, VEGFA, IGF1, GH1
41retinoic acid43 248.9GH1, RARB, KRT8, CTNNB1, MMP9, KRT14
42vegf437.9GH1, CTNNB1, BRAF, VEGFA, IGF1, MMP9
43progesterone43 28 59 24 1211.9KRT14, CTNNB1, IGF1, PRL, BRAF, KRT8
44tamoxifen43 49 28 1210.8IGF1, KRT8, KRT14, GH1, PRL, VEGFA
45genistein43 28 59 2 24 1212.7CTNNB1, RARB, KRT8, GH1, MMP9, VEGFA
46cycloheximide437.7IGF1, KRT8, CTNNB1, RARB, VEGFA, GH1
47testosterone43 59 24 1210.4IGF1, HCRT, MMP9, PROP1, GH1, RARB
48dexamethasone43 49 28 1210.2GH1, RARB, CTNNB1, PRL, MMP9, VEGFA
49tyrosine436.8HCRT, VEGFA, BRAF, MMP9, GH1, RARB
50estrogen436.2KRT14, HCRT, BRAF, MMP9, PRL, GH1

GO Terms for genes affiliated with Craniopharyngioma

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Cellular components related to Craniopharyngioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell peripheryGO:00719449.6CTNNB1, KRT14
2proteinaceous extracellular matrixGO:00055788.6ENAM, MMP9, VEGFA
3extracellular regionGO:00055767.3GH1, IGF1, HCRT, VEGFA, MMP9, PRL

Biological processes related to Craniopharyngioma according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1myoblast differentiationGO:004544510.1IGF1, CTNNB1
2regulation of myelinationGO:003164110.1CTNNB1, RARB
3negative regulation of chondrocyte differentiationGO:003233110.0RARB, CTNNB1
4positive regulation of insulin-like growth factor receptor signaling pathwayGO:004356810.0GH1, IGF1
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9GH1, IGF1
6embryonic hindlimb morphogenesisGO:00351169.8CTNNB1, RARB
7positive regulation of JAK-STAT cascadeGO:00464279.8PRL, GH1
8JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.7GH1, PRL
9positive regulation of neuroblast proliferationGO:00020529.6VEGFA, CTNNB1
10regulation of multicellular organism growthGO:00400149.6PRL, IGF1
11positive regulation of receptor internalizationGO:00020929.5VEGFA, GH1
12macrophage differentiationGO:00302259.4VEGFA, MMP9
13positive regulation of mesenchymal cell proliferationGO:00020539.4VEGFA, CTNNB1
14branching morphogenesis of an epithelial tubeGO:00487549.4IGF1, VEGFA
15patterning of blood vesselsGO:00015699.3VEGFA, CTNNB1
16positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2GH1, VEGFA, IGF1
17cell maturationGO:00484699.1CTNNB1, VEGFA
18lactationGO:00075959.0PRL, VEGFA
19negative regulation of transcription from RNA polymerase II promoterGO:00001228.9VEGFA, PROP1, RARB, CTNNB1
20positive regulation of transcription from RNA polymerase II promoterGO:00459448.6IGF1, VEGFA, PROP1, RARB, CTNNB1

Molecular functions related to Craniopharyngioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00051489.5PRL, GH1
2protein complex bindingGO:00324039.4CTNNB1, KRT8, RARB
3hormone activityGO:00051799.0GH1, PRL, IGF1
4growth factor activityGO:00080838.6IGF1, VEGFA, GH1
5protein bindingGO:00055155.9CTNNB1, IGF1, VEGFA, BRAF, MMP9, PRL

Products for genes affiliated with Craniopharyngioma

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Sources for Craniopharyngioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet