MCID: CRN036
MIFTS: 52

Craniopharyngioma malady

Neuronal, Endocrine, Cancer categories

Summaries for Craniopharyngioma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves). this tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected. craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum.[orphanet] craniopharyngioma is treated with surgery alone or by surgery followed by radiation. last updated: 4/3/2009

MalaCards: Craniopharyngioma, also known as dysodontogenic epithelial tumor, is related to adenoma and papillary craniopharyngioma. An important gene associated with Craniopharyngioma is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Glioma and Id Signaling Pathway. The compounds cycloheximide and gnrh have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:64 Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs... more...

Aliases & Classifications for Craniopharyngioma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal, Endocrine


Characteristics (Orphanet epidemiological data):

49
craniopharyngioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

craniopharyngioma 8 43 10 45 49 61
dysodontogenic epithelial tumor 43
craniopharyngeal duct tumor 43
neoplasm of rathke's pouch 8
adamantinomatous tumor 43
rathke's pouch tumor 43


External Ids:

Disease Ontology8 DOID:3840
MeSH35 D003397
NCIt40 C2964
MESH via Orphanet36 D003397
SNOMED-CT57 40009002, 189179009
ICD10 via Orphanet26 D44.4
SNOMED-CT via Orphanet58 189179009, 40009002
UMLS via Orphanet62 C0010276

Related Diseases for Craniopharyngioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Craniopharyngioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.7PROP1, PRL, GH1, CTNNB1, IGF1, RARB
2papillary craniopharyngioma30.6CTNNB1, KRT7
3panhypopituitarism30.3HESX1, GH1, PRL, PROP1, IGF1
4astrocytoma30.2VEGFA, MMP9, RARB
5pituitary tumors30.2GH1, PRL, PROP1, IGF1
6growth hormone deficiency30.2HESX1, GH1, PRL, PROP1, IGF1
7precocious puberty30.2GH1, PRL, IGF1
8pilomatrixoma30.0S100A3, CTNNB1
9chromophobe adenoma30.0GH1, PRL
10prolactinoma29.8GH1, PRL, IGF1
11hypoglycemia29.8GH1, PRL, IGF1, HCRT
12acromegaly29.8GH1, PRL, IGF1
13prader-willi syndrome29.8HCRT, IGF1, GH1
14turner syndrome29.8IGF1
15anorexia nervosa29.8GH1, PRL, IGF1, HCRT
16adamantinous craniopharyngioma10.2
17diabetes insipidus10.2
18gardner syndrome10.2
19subependymoma10.1
20olfactory neuroblastoma10.0
21central pontine myelinolysis10.0
22anterograde amnesia10.0
23morbid obesity10.0
24adult syndrome10.0
25diencephalic syndrome10.0
26pilocytic astrocytoma10.0
27extrapontine myelinolysis10.0
28liver cirrhosis10.0KRT8
29galactosemia10.0IGF1
30ductal carcinoma in situ10.0KRT14
31meningioma10.0S100A5
32neuroendocrine tumor10.0PRL
33myotonic dystrophy10.0HCRT
34leiomyoma10.0LGALS1
35sarcoma10.0LGALS1, KRT8
36endometriosis10.0VEGFA
37pituitary hypoplasia10.0PROP1, HESX1
38leukoplakia10.0KRT8, RARB
39chordoma10.0KRT14, KRT7, KRT8
40leiomyosarcoma10.0LGALS1, KRT8
41malignant mesothelioma10.0KRT7
42cervical cancer10.0KRT14, RARB, RARS
43psoriasis10.0KRT14, RARS
44colon adenocarcinoma10.0RARB, CTNNB1
45acanthosis nigricans10.0IGF1
46dementia10.0HCRT
47cervical intraepithelial neoplasia10.0KRT8
48oral cancer10.0MMP9, RARB, KRT14
49cholangiocarcinoma10.0KRT8, KRT7
50pituitary gland disease10.0GH1, PRL, IGF1

Graphical network of the top 20 diseases related to Craniopharyngioma:



Diseases related to craniopharyngioma

Clinical Features for Craniopharyngioma

Drugs & Therapeutics for Craniopharyngioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Craniopharyngioma

Drug clinical trials:

Search ClinicalTrials for Craniopharyngioma

Search NIH Clinical Center for Craniopharyngioma

Search CenterWatch for Craniopharyngioma

Genetic Tests for Craniopharyngioma

Anatomical Context for Craniopharyngioma

Animal Models for Craniopharyngioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Craniopharyngioma

Sources:
51PubMed
See all sources

Articles related to Craniopharyngioma:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Tight junction protein claudin-1 is differentially expressed in craniopharyngioma subtypes and indicates invasive tumor growth. (24305709)
2014
2
Subgaleal recurrence of craniopharyngioma of rapid growing pattern. (23686436)
2013
3
Retinal NFL thinning on OCT correlates with visual field loss in pediatric craniopharyngioma. (24314410)
2013
4
Evaluation of children with craniopharyngioma using carbon-11 methionine PET prior to proton therapy. (23408862)
2013
5
All-trans retinoic acid inhibits craniopharyngioma cell growth: study on an explant cell model. (23423514)
2013
6
Anterior cerebral artery dissecting aneurysm associated with untreated craniopharyngioma. (22762270)
2013
7
Tumor origin and growth pattern at diagnosis and surgical hypothalamic damage predict obesity in pediatric craniopharyngioma. (23579339)
2013
8
Initial visual field as a predictor of recurrence and postoperative visual outcome in children with craniopharyngioma. (21323242)
2012
9
Craniopharyngioma: a pathologic, clinical, and surgical review. (21584897)
2012
10
A case of fetal craniopharyngioma. (22550703)
2012
11
Primary isolated cerebellopontine angle papillary craniopharyngioma. (22954990)
2012
12
Intracystic therapies for cystic craniopharyngioma in childhood. (22654864)
2012
13
Hypothalamic obesity in patients with craniopharyngioma: treatment approaches and the emerging role of gastric bypass surgery. (21935755)
2012
14
Commentary: navigating a data desert: cochrane leaves the question of intracystic bleomycin unanswered in craniopharyngioma. (22902335)
2012
15
Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. (21814723)
2011
16
Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferon. (21359423)
2011
17
Long-term clinical outcomes following treatment of childhood craniopharyngioma. (21488157)
2011
18
Childhood craniopharyngioma in Macedonia: incidence and outcome after subtotal resection and cranial irradiation. (21191780)
2011
19
Predicting behavioral problems in craniopharyngioma survivors after conformal radiation therapy. (19191345)
2009
20
Hypothalamic involvement predicts cardiovascular risk in adults with childhood onset craniopharyngioma on long-term GH therapy. (19667040)
2009
21
Modified orbitozygomatic craniotomy for craniopharyngioma resection in children. (19795966)
2009
22
Vascular abnormalities in pediatric craniopharyngioma patients treated with radiation therapy. (18937328)
2009
23
Epithelial cell adhesion molecule (EpCAM) expression in adamantinomatous craniopharyngioma. (19917481)
2009
24
Surgical treatment of ectopic recurrence of craniopharyngioma. Report of 4 cases. (19645541)
2009
25
Craniopharyngioma surgery. (18636330)
2008
26
Entire infrasellar craniopharyngioma simulating clival chordoma. (18036439)
2007
27
Clinical picture of craniopharyngioma in childhood. (17703145)
2007
28
Ectopic craniopharyngioma of the fourth ventricle: case report. (17586238)
2007
29
Uncommon presentation of craniopharyngioma with anemia in an adolescent. (16047369)
2006
30
Combined proton and photon irradiation for craniopharyngioma: long-term results of the early cohort of patients treated at Harvard Cyclotron Laboratory and Massachusetts General Hospital. (16580494)
2006
31
GH replacement does not increase the risk of recurrence in patients with craniopharyngioma. (16649976)
2006
32
Endoscopy-assisted microsurgical total resection of craniopharyngioma in childhood. (17323266)
2006
33
Quality of life in treated adult craniopharyngioma patients. (16498063)
2006
34
Sphenoid sinus craniopharyngioma simulating mucocele. (16796313)
2006
35
Re: Ectopic recurrence of craniopharyngioma. (16540322)
2006
36
Cranial base strategies for resection of craniopharyngioma in children. (16048295)
2005
37
Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma. (16133276)
2005
38
Intraoperative cytologic crush preparation findings in craniopharyngioma: a study of 72 cases. (15717747)
2005
39
Adult craniopharyngioma. Clinical, radiological presentation and outcome of management. (23377247)
2004
40
Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. (15240606)
2004
41
Kerry's story: the challenges of facing a recurrent craniopharyngioma. (15663314)
2004
42
Transsphenoidal microsurgery for pediatric craniopharyngioma: special considerations regarding indications and method. (12845200)
2003
43
Spontaneously ruptured craniopharyngioma cyst without meningitic symptoms --two case reports. (12699125)
2003
44
Volumetric bone mineral density in patients with childhood craniopharyngioma. (12784191)
2003
45
Radiotherapy for craniopharyngioma in children: a national audit. (12602548)
2003
46
Ectopic clival craniopharyngioma. (12434179)
2002
47
Intratumoural bleomycin as a treatment for recurrent cystic craniopharyngioma. Case report and review of the literature. (12529778)
2002
48
Hormonal factors influencing weight and growth pattern in craniopharyngioma. (11044799)
2000
49
Proliferative activity in craniopharyngiomas: clinicopathological correlations in adults and children. (11118571)
2000
50
Silver-Russell syndrome and craniopharyngioma. (7189211)
1980

Genetic Variations for Craniopharyngioma

Expression for genes affiliated with Craniopharyngioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Craniopharyngioma

Search GEO for disease gene expression data for Craniopharyngioma.

Pathways for genes affiliated with Craniopharyngioma

Sources:
30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Craniopharyngioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4IGF1
210.4IGF1, VEGFA, CTNNB1
310.4CTNNB1, VEGFA, MMP9
410.4KRT14, KRT7, KRT8
510.4CTNNB1, MMP9, RARB
610.4MMP9, IGF1, VEGFA, CTNNB1
710.3MMP9, IGF1, VEGFA, GH1
810.3RARB, IGF1, VEGFA, CTNNB1

Compounds for genes affiliated with Craniopharyngioma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Craniopharyngioma according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.8KRT8
2gnrh4510.8HESX1, GH1, PROP1, HCRT
3quinagolide4510.8IGF1, PRL, GH1
4ghrp4510.8GH1, PRL, IGF1
5matrigel4510.8CTNNB1, KRT7, KRT8, LGALS1
6hexarelin45 2911.7GH1, PRL, IGF1
7pyridostigmine45 1111.7GH1, PRL, IGF1
8vitamin a45 11 2412.7CTNNB1, MMP9, RARS, RARB, KRT14
9lanreotide45 2911.7GH1, PRL, IGF1
10octreotide45 60 29 1113.7IGF1, VEGFA, PRL, GH1
11acth4510.7HESX1, GH1, PRL, PROP1, IGF1, HCRT
12leuprolide acetate4510.7GH1, PRL, IGF1
13dopamine45 29 11 2413.7CTNNB1, IGF1, HCRT, MMP9, RARB
14hematoxylin4510.7MMP9, KRT14, KRT7, KRT8
15tamoxifen45 50 29 1113.7CTNNB1, GH1, PRL, VEGFA, IGF1, KRT14
16clomiphene citrate4510.7IGF1, PRL, GH1
17naltrexone45 50 29 1113.7GH1, PRL, IGF1
18steroid4510.7GH1, PRL, PROP1, RARS, RARB, KRT8
19dexamethasone45 50 29 1113.7CTNNB1, GH1, VEGFA, HCRT, MMP9, RARB
20ribonucleic acid4510.7GH1, PRL, IGF1, HCRT, MMP9, RARB
21vitamin d4510.7CTNNB1, GH1, IGF1, RARS, RARB, KRT14
22cabergoline29 45 1112.7GH1, PRL, IGF1
23genistein45 29 60 2 11 2415.7CTNNB1, GH1, VEGFA, IGF1, MMP9, RARB
24somatuline4510.7IGF1, GH1
25actinomycin d4510.7GH1, VEGFA, IGF1, MMP9, RARB, KRT8
26paraffin4510.7CTNNB1, GH1, VEGFA, MMP9, KRT14, KRT7
27glucose4510.7IGF1, HCRT, KRT14, KRT7, KRT8, LGALS1
28retinoid4510.7CTNNB1, GH1, RARS, RARB, KRT14, KRT7
29isotretinoin45 1111.6KRT14, RARB, RARS
30chloramphenicol45 2 1112.6GH1, MMP9, RARS, RARB, KRT14
31sb 20358045 6011.6MMP9, IGF1, VEGFA, GH1, CTNNB1
32hydrocortisone45 2 60 1113.6GH1, PRL, IGF1, KRT14
33progesterone45 60 29 11 2414.6CTNNB1, GH1, PRL, IGF1, RARS, RARB
34cysteine4510.6CTNNB1, MMP9, RARS, RARB, KRT14, KRT8
35dihydrotestosterone45 29 11 2413.6PRL, GH1
36arginine4510.6CTNNB1, GH1, PRL, IGF1, RARS, RARB
37retinoic acid45 2411.6CTNNB1, GH1, IGF1, MMP9, RARS, RARB
38bromodeoxyuridine4510.6KRT8, KRT14, RARS, CTNNB1
39ciglitazone45 2911.6GH1, MMP9, RARB
40vegf4510.6CTNNB1, GH1, VEGFA, IGF1, MMP9, KRT7
41testosterone45 60 11 2413.6KRT8, CTNNB1, GH1, PRL, PROP1, IGF1
42tyrosine4510.5CTNNB1, GH1, VEGFA, IGF1, HCRT, MMP9
43ttab4510.5RARS, RARB
44thyroxine45 2411.5HCRT, IGF1, PRL, GH1
45cd 20194510.5RARS, RARB
46estradiol45 11 2412.4RARB, HCRT, PRL
47n-(4-hydroxyphenyl)retinamide4510.4RARB, RARS, IGF1
48bromocriptine29 45 1112.3PRL
49serine4510.2CTNNB1, GH1, PROP1, IGF1, MMP9, KRT14
50am 5804510.1RARS, RARB

GO Terms for genes affiliated with Craniopharyngioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Craniopharyngioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.4KRT8, KRT7, KRT14
2secretory granuleGO:03014110.3HCRT, VEGFA, PRL
3keratin filamentGO:04509510.1KRT8, KRT7, KRT14

Biological processes related to Craniopharyngioma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1myoblast differentiationGO:04544510.6LGALS1, IGF1, CTNNB1
2positive regulation of epithelial cell proliferationGO:05067910.6IGF1, VEGFA, PRL
3multicellular organismal response to stressGO:03355510.6PRL, LGALS1
4response to estradiol stimulusGO:03235510.5PRL, GH1, CTNNB1
5positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.4GH1, VEGFA, IGF1
6positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.4IGF1, GH1
7macrophage differentiationGO:03022510.4MMP9, VEGFA
8negative regulation of chondrocyte differentiationGO:03233110.3RARB, CTNNB1
9positive regulation of JAK-STAT cascadeGO:04642710.1PRL, GH1

Molecular functions related to Craniopharyngioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.4IGF1, PRL, GH1
2prolactin receptor bindingGO:00514810.1PRL, GH1
3protein bindingGO:0055159.9LGALS1, HESX1, CTNNB1, GH1, PRL, VEGFA

Products for genes affiliated with Craniopharyngioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Craniopharyngioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet