MCID: CRN036
MIFTS: 62

Craniopharyngioma malady

Neuronal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Craniopharyngioma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves). this tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected. craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum.[orphanet] craniopharyngioma is treated with surgery alone or by surgery followed by radiation. last updated: 4/3/2009

MalaCards: Craniopharyngioma, also known as dysodontogenic epithelial tumor, is related to obesity and adenoma. An important gene associated with Craniopharyngioma is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Glioma and Glioblastoma Multiforme. The compounds cycloheximide and gnrh have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and hypothalamus, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:63 Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue, that occurs... more...

Aliases & Classifications for Craniopharyngioma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
craniopharyngioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

craniopharyngioma 8 42 10 44 48 60
dysodontogenic epithelial tumor 42
craniopharyngeal duct tumor 42
neoplasm of rathke's pouch 8
adamantinomatous tumor 42
rathke's pouch tumor 42


External Ids:

Disease Ontology8 DOID:3840
MeSH34 D003397
NCIt39 C2964
MESH via Orphanet35 D003397
SNOMED-CT56 40009002, 189179009
ICD10 via Orphanet26 D44.4
SNOMED-CT via Orphanet57 189179009, 40009002
UMLS via Orphanet61 C0010276

Related Diseases for Craniopharyngioma

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17GeneCards, 18GeneDecks
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Diseases related to Craniopharyngioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.9HESX1, HCRT, GH1, IGF1, PROP1
2adenoma30.7PRL, IGF1, BRAF, CTNNB1, GH1, PROP1
3pituitary adenoma30.6GH1, IGF1, PROP1, PRL
4papillary craniopharyngioma30.6KRT7, CTNNB1
5panhypopituitarism30.3GH1, IGF1, PRL, HESX1, PROP1
6astrocytoma30.2RARB, VEGFA, MMP9
7meningioma30.1S100A5
8hypopituitarism30.1PROP1, PRL, IGF1, GH1, HESX1
9chordoma30.0KRT14, KRT7, KRT8
10pilomatrixoma30.0CTNNB1, S100A3
11chromophobe adenoma30.0PRL, GH1
12cholesteatoma29.8RARB, LGALS1, KRT14, MMP9
13prolactinoma29.8PRL, IGF1, GH1
14leukemia29.8RARB, RARS, LGALS1, KRT14
15hypogonadism29.8IGF1, PRL, GH1, PROP1
16hypoglycemia29.8HCRT, GH1, PRL, IGF1
17acromegaly29.8IGF1, GH1, PRL
18hypogonadotropism29.8PRL
19prader-willi syndrome29.8IGF1, GH1, HCRT
20turner syndrome29.7IGF1
21melanoma29.7KRT8, KRT14, RARS, MMP9, HCRT, VEGFA
22anorexia nervosa29.7PRL, GH1, IGF1, HCRT
23cerebritis10.2
24adamantinous craniopharyngioma10.2
25diabetes insipidus10.2
26meningitis10.1
27olfactory neuroblastoma10.0
28central pontine myelinolysis10.0
29anterograde amnesia10.0
30morbid obesity10.0
31adult syndrome10.0
32diabetes mellitus10.0
33functioning pituitary adenoma10.0
34neuroblastoma10.0
35retinitis10.0
36liver cirrhosis10.0KRT8
37neuroendocrine tumor10.0PRL
38galactosemia10.0IGF1
39endometriosis10.0VEGFA
40ductal carcinoma in situ10.0KRT14
41myotonic dystrophy10.0HCRT
42leiomyoma10.0LGALS1
43papilloma10.0KRT14
44colon adenocarcinoma10.0CTNNB1, RARB
45pituitary hypoplasia10.0PROP1, HESX1
46leukoplakia10.0RARB, KRT8
47malignant mesothelioma10.0KRT7
48leiomyosarcoma10.0KRT8, LGALS1
49acanthosis nigricans10.0IGF1
50psoriasis10.0KRT14, RARS

Graphical network of the top 20 diseases related to Craniopharyngioma:



Diseases related to craniopharyngioma

Clinical Features for Craniopharyngioma

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Drugs & Therapeutics for Craniopharyngioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Craniopharyngioma

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Genetic Tests for Craniopharyngioma

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Anatomical Context for Craniopharyngioma

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32MalaCards
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MalaCards organs/tissues related to Craniopharyngioma:

32
Pituitary, Brain, Hypothalamus, Bone, Endothelial, Skin, Testes, Temporal lobe

Animal Models for Craniopharyngioma or affiliated genes

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36MGI
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Publications for Craniopharyngioma

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50PubMed
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Articles related to Craniopharyngioma:

(show top 50)    (show all 577)
idTitleAuthorsYear
1
A rare presentation of craniopharyngioma: delayed puberty. (23195827)
2012
2
Xanthogranuloma, Rathke's cyst, and childhood craniopharyngioma: results of prospective multinational studies of children and adolescents with rare sellar malformations. (22969141)
2012
3
Acute visual loss in pregnancy caused by craniopharyngioma. (24269396)
2012
4
Treatment of craniopharyngioma in adults: systematic analysis of a 25-year experience. (22824214)
2012
5
Functional Neuroimaging in Craniopharyngioma: A Useful Tool to Better Understand Hypothalamic Obesity? (22647305)
2012
6
Primary cerebellopontine angle craniopharyngioma in a patient with Gardner syndrome. (21216148)
2011
7
EGFR signaling regulates tumor cell migration in craniopharyngiomas. (21562037)
2011
8
Incidence of craniopharyngioma in Denmark (nA =A 189) and estimated world incidence of craniopharyngioma in children and adults. (21336771)
2011
9
Toothy craniopharyngioma: a literature review and case report of craniopharyngioma with extensive odontogenic differentiation and tooth formation. (20922394)
2011
10
Intrinsic third ventricular craniopharyngioma: A case report. (21811661)
2011
11
Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy. (21603206)
2011
12
Craniopharyngioma: a comparison of tumor control with various treatment strategies. (20367362)
2010
13
Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence. (20190664)
2010
14
Childhood craniopharyngioma--current concepts in diagnosis, therapy and follow-up. (20877295)
2010
15
Ciliated craniopharyngioma--case report and pathological study. (19626269)
2010
16
Malignant transformation in craniopharyngioma after radiation therapy: a case report and review of the literature. (20040326)
2010
17
Stereotactic radiotherapy using Novalis for craniopharyngioma adjacent to optic pathways. (20422439)
2010
18
Craniopharyngioma in a patient with acromegaly due to a pituitary macroadenoma. (20864785)
2010
19
Extracranial infrasellar ectopic craniopharyngioma: a case report and review of the literature. (21772808)
2010
20
Distal gastric bypass surgery for the treatment of hypothalamic obesity after childhood craniopharyngioma. (19411299)
2009
21
Reversible clinical and magnetic resonance imaging of central pontine myelinolysis following surgery for craniopharyngioma: serial magnetic resonance imaging studies. (19318738)
2009
22
Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. (19636054)
2009
23
'Do no harm': management of craniopharyngioma. (18775978)
2008
24
Composite pituitary adenoma and craniopharyngioma?: an unusual sellar neoplasm with divergent differentiation. (18769335)
2008
25
Patients cured from craniopharyngioma or nonfunctioning pituitary macroadenoma (NFMA) suffer similarly from increased daytime somnolence despite normal sleep patterns compared to healthy controls. (18435832)
2008
26
Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. (17410335)
2007
27
Successfully treated acute lymphoblastic leukemia associated with craniopharyngioma. (17551406)
2007
28
Temporal extradural ectopic craniopharyngioma. Case report. (17639891)
2007
29
Intracystic bleomycin therapy for craniopharyngioma in children: the Canadian experience. (17407137)
2007
30
Gastric bypass surgery for treatment of hypothalamic obesity after craniopharyngioma therapy. (17643131)
2007
31
Late development of third ventricular subependymoma following surgery for craniopharyngioma. (17290937)
2007
32
Does chemotherapy have a role in the management of craniopharyngioma? (16700318)
2006
33
Conservative surgical approach in treatment strategy of craniopharyngioma: experience at a single institution in Italy. (16700309)
2006
34
Morphological and ultrastructural findings of prognostic impact in craniopharyngiomas. (16825115)
2006
35
Paediatric craniopharyngioma: a pathological review. (16700304)
2006
36
Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. (16000560)
2005
37
Hypothalamic obesity in a patient with craniopharyngioma: dysregulation of neurohormonal control of energy balance. (15800425)
2005
38
Monitoring the expression profiles of integrins and adhesion/growth-regulatory galectins in adamantinomatous craniopharyngiomas: their ability to regulate tumor adhesiveness to surrounding tissue and their contribution to prognosis. (15792515)
2005
39
Dramatic response of malignant craniopharyngioma to cis-platin-based chemotherapy. Should craniopharyngioma be considered as a suprasellar 'germ cell' tumour? (15799153)
2004
40
Prognosis and sequela in patients with childhood craniopharyngioma -- results of HIT-ENDO and update on KRANIOPHARYNGEOM 2000. (15565549)
2004
41
Radiotherapy of craniopharyngioma in childhood; single institution experience. (17415871)
2003
42
Successful pregnancy following gonadotropin therapy in a patient with hypogonadotropic hypogonadism resulting from craniopharyngioma. (11926704)
2002
43
Different keratin profiles in craniopharyngioma subtypes and ameloblastomas. (11770017)
2001
44
Pilocytic astrocytoma following radiotherapy for craniopharyngioma: case report. (10973118)
2000
45
Growth in children with craniopharyngioma following surgery. (10209560)
1998
46
The descriptive epidemiology of craniopharyngioma. (17206775)
1997
47
Craniopharyngioma: endocrine sequelae of treatment. (7841071)
1994
48
Papillary craniopharyngioma of the third ventricle--case report. (1283625)
1992
49
Craniopharyngioma and "reactive" subependymoma of the third ventricle--a case report. (3568466)
1987
50
Multiple primary intracranial tumors. (The development of a craniopharyngioma seventeen years after total removal of a parasagittal meningioma). (13982794)
1962

Genetic Variations for Craniopharyngioma

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Expression for genes affiliated with Craniopharyngioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Craniopharyngioma

Search GEO for disease gene expression data for Craniopharyngioma.

Pathways for genes affiliated with Craniopharyngioma

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29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB, 12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Craniopharyngioma

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Craniopharyngioma according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8KRT8
2gnrh4410.8GH1, PROP1, HESX1, HCRT
3quinagolide4410.8IGF1, PRL, GH1
4matrigel4410.8LGALS1, KRT8, KRT7, CTNNB1, BRAF
5ghrp4410.8IGF1, PRL, GH1
6pyridostigmine44 1111.7IGF1, PRL, GH1
7vitamin a44 11 2412.7MMP9, CTNNB1, RARB, KRT14, RARS
8hexarelin44 2811.7IGF1, PRL, GH1
9dopamine44 28 11 2413.7RARB, CTNNB1, IGF1, HCRT, MMP9
10acth4410.7PRL, IGF1, HCRT, PROP1, GH1, HESX1
11leuprolide acetate4410.7PRL, IGF1, GH1
12octreotide44 59 28 1113.7GH1, PRL, VEGFA, IGF1
13lanreotide44 2811.7IGF1, GH1, PRL
14hematoxylin4410.7MMP9, KRT14, KRT8, KRT7
15tamoxifen44 49 28 1113.7VEGFA, PRL, IGF1, GH1, CTNNB1, KRT14
16sb 20358044 5911.7BRAF, MMP9, IGF1, VEGFA, GH1, CTNNB1
17steroid4410.7GH1, PROP1, PRL, RARS, KRT8, RARB
18ribonucleic acid4410.7IGF1, HCRT, GH1, PRL, RARB, MMP9
19dexamethasone44 49 28 1113.7LGALS1, CTNNB1, GH1, VEGFA, HCRT, MMP9
20genistein44 28 59 2 11 2415.7VEGFA, KRT8, RARB, MMP9, IGF1, GH1
21vitamin d4410.7GH1, CTNNB1, IGF1, RARS, RARB, KRT14
22glucose4410.7IGF1, HCRT, KRT7, KRT8, LGALS1, KRT14
23clomiphene citrate4410.7IGF1, GH1, PRL
24actinomycin d4410.7MMP9, VEGFA, IGF1, RARB, KRT8, GH1
25naltrexone44 49 28 1113.7IGF1, GH1, PRL
26retinoid4410.6KRT8, GH1, RARS, RARB, KRT14, KRT7
27paraffin4410.6BRAF, GH1, VEGFA, MMP9, KRT14, KRT7
28agar4410.6KRT8, RARB, CTNNB1, BRAF, LGALS1
29vegf4410.6MMP9, BRAF, CTNNB1, GH1, VEGFA, IGF1
30serine4410.6PROP1, GH1, KRT14, KRT8, MMP9
31cabergoline28 44 1112.6PRL, IGF1, GH1
32chloramphenicol44 2 1112.6GH1, MMP9, RARS, RARB, KRT14
33progesterone44 59 28 11 2414.6CTNNB1, KRT8, KRT7, KRT14, RARB, RARS
34cysteine4410.6CTNNB1, MMP9, RARB, KRT8, LGALS1, RARS
35cisplatin44 49 59 1113.6VEGFA, KRT8, KRT14, RARB, CTNNB1, BRAF
36arginine4410.6GH1, BRAF, CTNNB1, PRL, IGF1, RARS
37retinoic acid44 2411.6KRT14, KRT7, MMP9, IGF1, GH1, CTNNB1
38isotretinoin44 1111.6KRT14, RARB, RARS
39testosterone44 59 11 2413.6KRT8, RARS, MMP9, HCRT, IGF1, PROP1
40hydrocortisone44 2 59 1113.6KRT14, PRL, IGF1, GH1
41cetuximab44 49 1112.5BRAF, CTNNB1, VEGFA
42tyrosine4410.5VEGFA, GH1, CTNNB1, LGALS1, IGF1, HCRT
43somatuline4410.5GH1, IGF1
44rapamycin4410.5BRAF, IGF1, CTNNB1, LGALS1, VEGFA
45lipid4410.5LGALS1, GH1, HCRT, RARB, KRT8, KRT14
46pd 98,0594410.4BRAF, GH1, IGF1, MMP9, CTNNB1
47ciglitazone44 2811.4RARB, MMP9, GH1
48ly2940024410.3IGF1, VEGFA, BRAF, CTNNB1, MMP9
49wortmannin4410.2MMP9, IGF1, BRAF, GH1, CTNNB1
50bromodeoxyuridine4410.1KRT14, KRT8, CTNNB1, RARS

GO Terms for genes affiliated with Craniopharyngioma

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16Gene Ontology
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Cellular components related to Craniopharyngioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.4KRT8, KRT7, KRT14
2secretory granuleGO:03014110.3HCRT, VEGFA, PRL
3keratin filamentGO:04509510.1KRT8, KRT7, KRT14

Biological processes related to Craniopharyngioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1myoblast differentiationGO:04544510.6LGALS1, IGF1, CTNNB1
2positive regulation of epithelial cell proliferationGO:05067910.5IGF1, VEGFA, PRL
3multicellular organismal response to stressGO:03355510.5LGALS1, PRL
4response to estradiol stimulusGO:03235510.5CTNNB1, GH1, PRL
5positive regulation of JAK-STAT cascadeGO:04642710.4PRL, GH1
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.4IGF1, VEGFA, GH1
7positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.3GH1, IGF1
8negative regulation of chondrocyte differentiationGO:03233110.1RARB, CTNNB1

Molecular functions related to Craniopharyngioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.4PRL, IGF1, GH1
2prolactin receptor bindingGO:00514810.1GH1, PRL
3protein bindingGO:0055159.9BRAF, MMP9, MCM6, IGF1, VEGFA, PRL

Products for genes affiliated with Craniopharyngioma

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  • Antibodies
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Sources for Craniopharyngioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet