CSO
MCID: CRN037
MIFTS: 67

Craniosynostosis (CSO) malady

Summaries for Craniosynostosis

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NINDS:43 Craniosynostosis is a birth defect of the brain characterized by the premature closure of one or more of the fibrous joints between the bones of the skull (called the cranial sutures) before brain growth is complete. Closure of a single suture is most common. In contrast to normal skull growth, in which the skull expands uniformly to accommodate the growth of the brain, premature closure of a single suture restricts the growth in that part of the skull and promotes growth in other parts of the skull where sutures remain open. This results in an abnormal shape of the skull, but does not prevent the brain from expanding to a normal volume. However, when many sutures close prematurely, the skull cannot expand to accommodate the growing brain, which leads to increased pressure within the skull and impaired development of the brain. Craniosynostosis can be gene-linked, or caused by metabolic diseases, such as rickets or an overactive thyroid. Some cases are associated with other disorders such as microcephaly (abnormally small head) and hydrocephalus (excessive accumulation of cerebrospinal fluid in the brain). The first sign of craniosynostosis is an abnormally shaped skull. Other features can include signs of increased intracranial pressure, developmental delays, or mental retardation, which are caused by constriction of the growing brain. Seizures and blindness may also occur.

MalaCards: Craniosynostosis, also known as premature closure of cranial sutures, is related to muenke syndrome and synostosis. An important gene associated with Craniosynostosis is MSX2 (msh homeobox 2), and among its related pathways are Alzheimers Disease Pathway and Akt Signaling Pathway . The compounds su5402 and pd 173074 have been mentioned in the context of this disorder. Affiliated tissues include skull, bone and brain, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Disease Ontology:8 A synostosis that results in premature fusion located in skull.

NIH Rare Diseases:42 Craniosynostosis is a birth defect of the brain characterized by the premature closure of one or more of the joints between the bones of the skull (called the cranial sutures) before brain growth is complete. the first sign is an abnormally shaped skull; other features can include signs of increased intracranial pressure, developmental delays, intellectual disability, seizures, and blindness, caused by constriction of the growing brain. closure of a single suture is most common and does not prevent the brain from expanding to a normal volume. when many sutures close prematurely, the skull cannot expand to accommodate the growing brain, leading to increased pressure and impaired development of the brain. craniosynostosis can be caused by genetic mutations, certain metabolic diseases (such as rickets or an overactive thyroid) or can be associated with other disorders such as microcephaly and hydrocephalus. treatment generally consists of surgery to improve the symmetry and appearance of the head and to relieve pressure on the brain and the cranial nerves. last updated: 3/31/2011

Wikipedia:63 Craniosynostosis (from cranio, cranium; + syn, together; + ostosis relating to bone) is a condition in... more...

Description from OMIM:46 123100,604757,182212

Aliases & Classifications for Craniosynostosis

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

craniosynostosis 8 42 22 43 10 44 60
premature closure of cranial sutures 8
craniostenosis 42
cso 42


External Ids:

Disease Ontology8 DOID:2340
NCIt39 C84655
MeSH34 D003398

Related Diseases for Craniosynostosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Craniosynostosis, Type 1 family:

craniosynostosis Fgfr3-Related Craniosynostosis
Craniosynostosis, Nonsyndromic Msx2-Related Craniosynostosis
Fgfr2-Related Craniosynostosis Fgfr1-Related Craniosynostosis
Twist1-Related Craniosynostosis Craniosynostosis, Type 2
Craniosynostosis 5 Craniosynostosis 3
Craniosynostosis 4

Diseases related to Craniosynostosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1muenke syndrome30.6FGFR2, FGFR1, FGFR3, TWIST1
2synostosis30.5FGFR2, TWIST1, MSX2, FGFR3, FGF10, FGFR1
3baller-gerold syndrome30.5TWIST1, RECQL4
4saethre-chotzen syndrome30.4FGFR3, FGFR1, MSX2, TWIST1, FGFR2
5crouzon syndrome30.4FGFR2, FGFR1, FGFR3, FGF2, MSX2
6fgfr-related craniosynostosis syndromes30.3FGFR3, FGFR1, FGFR2
7syndactyly30.2MSX2, FGFR2, FGF8, FGFR3
8acrocephalosyndactylia30.2FGFR2, FGFR1, FGF10, FGF2, FGFR3
9jackson-weiss syndrome30.2FGFR2, FGFR3, FGFR1
10infectious mononucleosis30.1FGFR1, FGFR2
11achondroplasia30.0MSX2, FGF9, FGFR3, FGFR2
12beare-stevenson cutis gyrata syndrome30.0FGFR2
13cleft palate29.9TWIST1, FGF10, FGFR1, FGFR2
14osteoglophonic dysplasia29.6FGFR1
15cleft lip29.6EFNB1, FGF10, FGFR1
16endometrial carcinoma29.6FGFR2, FGF10
17hypospadias29.6FGFR2, FGF10, FGF8
18dwarfism29.6FGFR1, FGFR2, FGFR3
19cataract29.6RECQL4
20polydactyly29.6FGF8, FGFR2
21hypophosphatasia29.6ENPP1
22shprintzen-goldberg syndrome10.4
23craniosynostosis, type 110.2
24craniosynostosis, type 210.2
25craniosynostosis 410.2
26papilledema10.2
27genoa syndrome10.2
28hunter-mcalpine syndrome10.2
29herrmann opitz craniosynostosis10.2
30craniosynostosis and dental anomalies10.2
31craniosynostosis 510.2
32microcephaly10.1
33craniosynostosis, anal anomalies, and porokeratosis10.1
34craniosynostosis philadelphia type10.1
35dandy-walker malformation with sagittal craniosynostosis and hydrocephalus10.1
36goldberg-shprintzen megacolon syndrome10.1
37craniosynostosis 310.1
38craniosynostosis - dandy-walker malformation - hydrocephalus10.1
39brachydactyly10.1
40rickets10.1
41pycnodysostosis10.1
42holoprosencephaly10.1
43hydrocephalus10.1
44strabismus10.1
45osteopetrosis10.0
46klippel-feil syndrome10.0
47porokeratosis10.0
48hypertension10.0
49intracranial hypertension10.0
50sleep disorder10.0

Graphical network of the top 20 diseases related to Craniosynostosis:



Diseases related to craniosynostosis

Clinical Features for Craniosynostosis

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46OMIM
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Clinical features from OMIM:

123100,604757,182212

Drugs & Therapeutics for Craniosynostosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Craniosynostosis

Drug clinical trials:

Search ClinicalTrials for Craniosynostosis

Search NIH Clinical Center for Craniosynostosis

Search CenterWatch for Craniosynostosis

Genetic Tests for Craniosynostosis

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22GTR
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Genetic tests related to Craniosynostosis:

id Genetic test Affiliating Genes
1 Craniosynostosis Syndrome22

Anatomical Context for Craniosynostosis

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30LifeMap Discovery™, 32MalaCards, 14FMA
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MalaCards organs/tissues related to Craniosynostosis:

32
Bone, Brain, Thyroid, Prostate, Skin, Kidney, Heart, Eye, Bone marrow

FMA organs/tissues related to Craniosynostosis:

14
Skull

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Craniosynostosis:
id TissueAnatomical CompartmentCell Relevance
1 BoneFacial SuturesFacial Presumptive Suture Cells Affected by disease
2 BoneFacial SuturesFacial Suture Cells Affected by disease
3 BoneRostral SuturesRostral Presumptive Suture Cells Affected by disease
4 BoneRostral SuturesRostral Suture Cells Affected by disease

Animal Models for Craniosynostosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Craniosynostosis:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.8ANKH, EFNB1, RECQL4, FGF9, LRP5, MSX2
2MP:000538210.8FBN1, TWIST1, MSX2, LRP5, FGF9, FGFR3
3MP:000537710.8ANKH, EFNB1, FGFR2, FGFR1, FGF10, FGF8
4MP:000539010.8FBN1, NELL1, TWIST1, ENPP1, MSX2, LRP5
5MP:000538110.7EFNB1, RECQL4, FGFR2, FGFR1, FGF10, FGF8
6MP:000538010.7FBN1, RHBDF1, EFNB1, RECQL4, FGFR2, FGFR1
7MP:000537810.7FGFR1, FGFR2, RECQL4, EFNB1, ANKH, RHBDF1
8MP:000536910.7FBN1, ANKH, FGFR1, FGF10, FGF8, FGF9
9MP:001076810.7FGFR1, FGFR2, RECQL4, EFNB1, ANKH, RHBDF1
10MP:000538510.7FGF10, FGFR1, FGFR2, ANKH, FBN1, FGF8
11MP:000539110.7FGFR1, FGFR2, RECQL4, EFNB1, FGF10, FGF8
12MP:000539710.7RECQL4, EFNB1, ANKH, RHBDF1, FBN1, FGFR2
13MP:001077110.7FBN1, RHBDF1, RECQL4, FGFR2, FGFR1, FGF10
14MP:000538610.7FBN1, NELL1, ANKH, FGFR2, FGFR1, FGF8
15MP:000538410.7FGFR1, FGFR2, RECQL4, EFNB1, ANKH, FBN1
16MP:000538710.6FGFR2, RECQL4, EFNB1, ANKH, FBN1, FGFR1
17MP:000363110.6FGF10, FGFR1, FGFR2, EFNB1, FBN1, FGF8
18MP:000537910.6FBN1, FGFR2, FGFR1, MSX2
19MP:000538910.6FBN1, ANKH, EFNB1, FGFR2, FGF10, FGF8
20MP:000538810.5NELL1, ANKH, EFNB1, FGFR2, FGF10, FGFR3
21MP:000287310.4FGFR1, FGF10, FGF8, FGFR3, FGF9, LRP5
22MP:000537610.4FBN1, ANKH, EFNB1, FGFR2, FGF10, FGF8
23MP:000118610.4MSX2
24MP:000536710.1FBN1, ANKH, FGFR2, FGFR1, FGF10, FGF8

Publications for Craniosynostosis

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50PubMed
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Articles related to Craniosynostosis:

(show top 50)    (show all 642)
idTitleAuthorsYear
1
Longitudinal study of the neurodevelopmental characteristics of treated and untreated nonsyndromic craniosynostosis in infancy. (23358908)
2013
2
Venous air embolism from Tisseel use during endoscopic cranial vault remodeling for craniosynostosis repair: a case report. (23746210)
2013
3
Mucopolysaccharidosis type I and craniosynostosis. (23917744)
2013
4
Nummular Headache in a Patient with Craniosynostosis: One More Evidence for a Peripheral Mechanism. (24341452)
2013
5
Cranial vault growth in multiple-suture nonsyndromic and syndromic craniosynostosis: a postoperative long-term anthropometric follow-up. (23714873)
2013
6
RUNX2 quadruplication: additional evidence toward a new form of syndromic craniosynostosis. (23348268)
2013
7
Craniosynostosis with wormian bone, bowing of the long bones, unilateral short femur, and focal fibula deficiency: a prenatal diagnostic dilemma. (23090838)
2013
8
Long-term incidence of sensory disturbance in the forehead after fronto-orbital advancement in isolated nonsyndromic craniosynostosis. (23948504)
2013
9
No man's craniosynostosis: the arcana of sutural knowledge. (22337438)
2012
10
Does central sleep apnea occur in children with syndromic craniosynostosis? (22484378)
2012
11
Frank-ter Haar syndrome associated with sagittal craniosynostosis and raised intracranial pressure. (23140272)
2012
12
Current approaches to management of nonsyndromic craniosynostosis. (22894999)
2012
13
Simultaneous and differential fronto-orbital and midface distraction osteogenesis for syndromic craniosynostosis using rigid external distractor II. (22976628)
2012
14
Commentary on "Nonsyndromic craniosynostosis: the Rady Children's Hospital approach". (23154352)
2012
15
MSX2 copy number increase and craniosynostosis: copy number variation detected by array comparative genomic hybridization. (22948472)
2012
16
Split calvarial bone grafting in patients less than 1 year of age: technical note and use in craniofacial surgery for craniosynostosis. (21476034)
2011
17
Endoscopically assisted correction of sagittal craniosynostosis. (21530705)
2011
18
Factors influencing blood loss and allogeneic blood transfusion practice in craniosynostosis surgery. (21919993)
2011
19
Cranial vault remodeling for sagittal craniosynostosis in older children. (21806342)
2011
20
Whole cranial vault expansion by continual occipital and fronto-orbital distraction in syndromic craniosynostosis. (21233733)
2011
21
Associations between periconceptional alcohol consumption and craniosynostosis, omphalocele, and gastroschisis. (21630421)
2011
22
Obstructive sleep apnea-specific quality of life and behavioral problems in children with syndromic craniosynostosis. (21297497)
2011
23
Operative treatment for microcephaly secondary to craniosynostosis at the turn of the twentieth century. (21792520)
2011
24
A primer on craniosynostosis. (21322454)
2010-2011
25
Genetic basis of potential therapeutic strategies for craniosynostosis. (21082653)
2010
26
Common primary fibroblastic growth factor receptor-related craniosynostosis syndromes: A pictorial review. (21042516)
2010
27
Craniosynostosis in pycnodysostosis: broadening the spectrum of the cranial flat bone abnormalities. (20814951)
2010
28
Holoprosencephaly and craniosynostosis: A report of two siblings and review of the literature. (20104614)
2010
29
Can parents predict obstructive sleep apnea in children with syndromic or complex craniosynostosis? (20206474)
2010
30
Craniosynostosis in Kabuki syndrome. (20672944)
2010
31
Role of parental risk factors in the aetiology of isolated non-syndromic metopic craniosynostosis. (20510490)
2010
32
Pediatric craniofacial surgery for craniosynostosis: Our experience and current concepts: Parts -2. (21887190)
2009
33
Characterization of the first FGFRL1 mutation identified in a craniosynostosis patient. (19056490)
2009
34
Evolution in the frequency of nonsyndromic craniosynostosis. (19569905)
2009
35
Perspectives on craniosynostosis: sutural biology, some well-known syndromes, and some unusual syndromes. (19293680)
2009
36
Fluctuating asymmetry and developmental instability in sagittal craniosynostosis. (19254065)
2009
37
Bioabsorbable osteofixation devices in craniosynostosis. Clinical experience in 216 cases. (19575129)
2009
38
Fibrinogen in craniosynostosis surgery. (18292409)
2008
39
The misdiagnosis of craniosynostosis as deformational plagiocephaly. (18216678)
2008
40
Complications in the surgical treatment of craniosynostosis and craniofacial syndromes: apropos of 306 transcranial procedures. (18769932)
2008
41
Cranial growth after distraction osteogenesis of the craniosynostosis. (18216664)
2008
42
Muenke syndrome (FGFR3-related craniosynostosis): expansion of the phenotype and review of the literature. (18000976)
2007
43
FGFR1 Pfeiffer syndrome without craniosynostosis: an additional case report. (16957473)
2006
44
Rapid development of Chiari I malformation in an infant with Seckel syndrome and craniosynostosis. Case report and review of the literature. (12744374)
2003
45
Syndrome of coronal craniosynostosis, Klippel-Feil anomaly, and sprengel shoulder with and without Pro250Arg mutation in the FGFR3 gene. (11746040)
2001
46
Craniosynostosis and related limb anomalies. (11277076)
2001
47
Craniosynostosis associated with FGFR3 pro250arg mutation results in a range of clinical presentations including unisutural sporadic craniosynostosis. (9279753)
1997
48
Frontonasal dysplasia with coronal craniosynostosis in three sibs. (526592)
1979
49
Syndrome of mental retardation, cleft palate, eventration of diaphragm, congenital heart defect, glaucoma, growth failure and craniosynostosis. (890093)
1977
50
Neonatal hyperthyroidism with accelerated skeletal maturation, craniosynostosis, and brachydactyly. (4642468)
1972

Genetic Variations for Craniosynostosis

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Expression for genes affiliated with Craniosynostosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Craniosynostosis

Search GEO for disease gene expression data for Craniosynostosis.

Pathways for genes affiliated with Craniosynostosis

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51QIAGEN, 52R&D Systems, 49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore
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Pathways related to Craniosynostosis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5FGFR3, FGFR1, FGFR2
210.5FGFR3, FGFR1, FGFR2
3
Hide members
10.5FGFR2, FGFR1, FGFR3
410.5LRP5
510.5FGF2, FGFR3, FGFR1, FGFR2
6
Hide members
10.5FGF2, FGF10, FGFR2
710.5FGFR1, FGFR3, FGF2, ENPP1
810.5EFNB1, FGFR2, FGFR1, FGFR3, FGF2
910.5EFNB1, FGFR2, FGFR1, FGFR3, FGF2
1010.5FGFR2, FGFR1, FGF8, FGFR3, FGF2, MSX2
11
Hide members
10.5FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
12
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGF9
13
Hide members
10.4FBN1, FGFR2, FGFR1, FGF10, FGF8, FGFR3
14
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
15
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
16
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
17
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
18
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
19
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
20
Hide members
10.4FGF2, FGFR3, FGF8, FGF10, FGFR1, FGFR2
21
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
22
Hide members
10.4FGF2, FGFR2, FGFR1, FGF10, FGF8, FGFR3
23
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
24
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
25
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
26
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
27
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
28
Development FGF-family signaling
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
29
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
3010.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
31
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
3210.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
33
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
3410.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
35
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
36
Hide members
10.4FBN1, FGFR2, FGFR1, FGF10, FGF8, FGFR3
37
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
38
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
3910.4FGFR1, FGF10, FGF8, FGF9, FGF2, TWIST1
40
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
41
Hide members
10.4FBN1, FGFR2, FGFR1, FGF10, FGF8, FGFR3

Compounds for genes affiliated with Craniosynostosis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Craniosynostosis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1su54024410.8FGF2, FGFR3, FGFR1, FGFR2
2pd 17307444 5911.8FGFR2, FGFR1, FGFR3, FGF2
3pd 1615705910.8FGFR2, FGFR1, FGFR3
4fiin 1 hydrochloride5910.8FGFR2, FGFR1, FGFR3
5su 54025910.8FGFR2, FGFR1, FGFR3
6palifermin44 1111.8FGFR2, FGFR1, FGFR3
7heparan sulfate44 2411.8FBN1, FGFR2, FGFR1, FGF10, FGF8, FGF2
8tyrosine4410.8FBN1, RHBDF1, EFNB1, FGFR2, FGFR1, FGF10
9Ponatinib 1110.8FGFR3, FGFR1, FGFR2
10chondroitin sulfate44 2411.8FBN1, FGFR2, FGFR1, FGF2
11heparin44 28 11 2413.8FBN1, FGFR2, FGFR1, FGF10, FGF8, FGF9
12SU49841110.7FGFR1, FGFR2
13suramin44 28 1112.7FGFR2, FGFR1, FGF8, FGF2
14sucrose octasulfate44 1111.7FGF2, FGFR2
15bromodeoxyuridine4410.7FGFR2, FGFR1, FGF10, FGF2
16vegf4410.7FGFR2, FGFR1, FGF10, FGFR3, FGF9, FGF2
17lysine4410.7FBN1, FGFR2, FGFR1, FGFR3, ENPP1
18calcium44 49 11 2413.6FBN1, ANKH, FGFR2, FGFR1, FGFR3, FGF9
19su66684410.6FGF2, FGFR1
20chlorate4410.6FGFR1, FGF2
21sodium chlorate4410.5FGFR1, FGF2
22sulfate44 2411.5ENPP1, FGFR3, FGFR2
23thalidomide44 49 59 1113.5FGF2, FGFR3, FGFR2
24retinoic acid44 2411.3FBN1, FGFR2, FGFR1, FGF10, FGF8, FGF2
25paclitaxel44 49 1112.2FGFR2, FGFR1, FGF2, TWIST1

GO Terms for genes affiliated with Craniosynostosis

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16Gene Ontology
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Cellular components related to Craniosynostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:01602310.5FGFR3, FGFR1, FGFR2
2extracellular regionGO:00557610.4FGF2, FBN1, NELL1, FGFR2, FGFR1, FGF10
3extracellular spaceGO:00561510.3FBN1, FGF10, FGF8, FGF9, FGF2, ENPP1
4integral to plasma membraneGO:00588710.2ANKH, EFNB1, FGFR2, FGFR1, FGFR3, IL11RA

Biological processes related to Craniosynostosis according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:01051810.9FGFR1, FGFR2, FGFR3
2positive regulation of MAPK cascadeGO:04341010.9FGF10, FGF9, FGFR3, FGFR2, FGFR1
3phosphatidylinositol-mediated signalingGO:04801510.9FGF8, FGF10, FGFR1, FGFR2, FGFR3, FGF2
4positive regulation of cardiac muscle cell proliferationGO:06004510.9FGFR1, FGF2, FGF9, FGFR2
5insulin receptor signaling pathwayGO:00828610.9FGF9, FGF2, FGFR2, FGFR3, FGFR1, FGF8
6positive regulation of mesenchymal cell proliferationGO:00205310.9LRP5, FGFR2, FGFR1, FGF9
7fibroblast growth factor receptor signaling pathwayGO:00854310.9FGF2, FGF10, FGFR2, FGFR1, FGF8, FGFR3
8Fc-epsilon receptor signaling pathwayGO:03809510.9FGF2, FGF8, FGFR3, FGF10, FGFR1, FGFR2
9lung-associated mesenchyme developmentGO:06048410.9FGF9, FGFR1, FGFR2
10organ inductionGO:00175910.9FGF2, FGFR1, FGF10, FGF8
11epidermal growth factor receptor signaling pathwayGO:00717310.9FGFR2, FGF10, FGF8, FGFR3, FGF9, FGFR1
12otic vesicle formationGO:03091610.9FGFR2, FGF8, FGF10
13positive regulation of canonical Wnt receptor signaling pathwayGO:09026310.9FGF9, FGFR3, FGF10, FGFR2
14neurotrophin TRK receptor signaling pathwayGO:04801110.9FGFR1, FGF2, FGF10, FGF8, FGFR3, FGF9
15outflow tract septum morphogenesisGO:00314810.9FGFR2, FGF8, MSX2
16branching involved in salivary gland morphogenesisGO:06044510.9FGFR2, FGF8, FGFR1
17positive regulation of cell proliferationGO:00828410.9FGFR2, FGFR1, LRP5, FGF8, FGFR3, FGF9
18positive regulation of cell divisionGO:05178110.9FGF9, FGF2, FGFR2, FGF8
19bone morphogenesisGO:06034910.9FGFR2, FGFR3, LRP5
20regulation of bone mineralizationGO:03050010.9ENPP1, TWIST1, ANKH
21mesenchymal cell differentiation involved in lung developmentGO:06091510.8FGFR2, FGF10
22positive regulation of ERK1 and ERK2 cascadeGO:07037410.8FGFR3, FGF10, FGFR2, FGF2
23branch elongation involved in salivary gland morphogenesisGO:06066710.8FGFR2, FGF10
24embryonic pattern specificationGO:00988010.8FGF10, FGFR2, EFNB1
25mammary gland bud formationGO:06061510.8FGFR2, FGF10
26innate immune responseGO:04508710.8FGF9, FGF10, FGFR1, FGF2, FGF8, FGFR3
27fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:06059510.8FGF10, FGFR2
28fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:03560710.8FGFR1, FGFR2
29substantia nigra developmentGO:02176210.8FGF2, FGFR3
30chondrocyte differentiationGO:00206210.8FGF9, FGFR1, FGFR3
31embryonic hindlimb morphogenesisGO:03511610.8TWIST1, MSX2, FGF8
32ventricular zone neuroblast divisionGO:02184710.8FGFR2, FGFR1
33skeletal system developmentGO:00150110.8FBN1, ANKH, FGFR1, FGFR3
34corticotropin hormone secreting cell differentiationGO:06012810.8FGF2, FGF8
35lacrimal gland developmentGO:03280810.8FGF10, FGFR2
36embryonic limb morphogenesisGO:03032610.8LRP5, FGF9, FGFR1
37regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.7FGFR1, FGF10
38endochondral bone growthGO:00341610.7MSX2, FGFR3
39thyroid-stimulating hormone-secreting cell differentiationGO:06012910.7FGF2, FGF8
40peptidyl-tyrosine phosphorylationGO:01810810.7FGFR1, FGFR2, FGFR3
41positive regulation of epithelial cell proliferationGO:05067910.7FGFR2, FGF10, FGF9
42osteoblast differentiationGO:00164910.7MSX2, TWIST1, FGF9
43positive regulation of osteoblast differentiationGO:04566910.6MSX2, FGF2, NELL1
44positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.6FGFR1, FGFR3
45cranial suture morphogenesisGO:06036310.6TWIST1, MSX2
46inner ear morphogenesisGO:04247210.5FGFR1, FGF9, FGFR2
47negative regulation of mitosisGO:04583910.5FGFR3, FGFR2
48angiogenesisGO:00152510.5FGFR1, FGF9, FGFR2, FGF10
49MAPK cascadeGO:00016510.4FGFR3, FGFR1, FGF8
50positive regulation of phospholipase C activityGO:01086310.2FGFR1, FGF2

Molecular functions related to Craniosynostosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:01713410.6FGF2, FGFR3, FGFR1, FGFR2
2fibroblast growth factor receptor bindingGO:00510410.6FGF10, FGF8, FGF9, FGF2
3fibroblast growth factor-activated receptor activityGO:00500710.5FGFR3, FGFR1, FGFR2
4protein tyrosine kinase activityGO:00471310.5FGFR3, FGFR1, FGFR2
5heparin bindingGO:00820110.5FGFR2, FGFR1, FGF10, FGF9, FGF2
6type 2 fibroblast growth factor receptor bindingGO:00511110.4FGF8, FGF10
7growth factor activityGO:00808310.1FGF10, FGF8, FGF9, FGF2

Products for genes affiliated with Craniosynostosis

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Sources for Craniosynostosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet