CSO
MCID: CRN037
MIFTS: 62

Craniosynostosis (CSO) malady

Summaries for Craniosynostosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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NINDS:44 Craniosynostosis is a birth defect of the brain characterized by the premature closure of one or more of the fibrous joints between the bones of the skull (called the cranial sutures) before brain growth is complete. Closure of a single suture is most common. In contrast to normal skull growth, in which the skull expands uniformly to accommodate the growth of the brain, premature closure of a single suture restricts the growth in that part of the skull and promotes growth in other parts of the skull where sutures remain open. This results in an abnormal shape of the skull, but does not prevent the brain from expanding to a normal volume. However, when many sutures close prematurely, the skull cannot expand to accommodate the growing brain, which leads to increased pressure within the skull and impaired development of the brain. Craniosynostosis can be gene-linked, or caused by metabolic diseases, such as rickets or an overactive thyroid. Some cases are associated with other disorders such as microcephaly (abnormally small head) and hydrocephalus (excessive accumulation of cerebrospinal fluid in the brain). The first sign of craniosynostosis is an abnormally shaped skull. Other features can include signs of increased intracranial pressure, developmental delays, or mental retardation, which are caused by constriction of the growing brain. Seizures and blindness may also occur.

MalaCards: Craniosynostosis, also known as premature closure of cranial sutures, is related to muenke syndrome and synostosis. An important gene associated with Craniosynostosis is MSX2 (msh homeobox 2), and among its related pathways are Alzheimers Disease Pathway and Akt Signaling Pathway . The compounds su5402 and pd 173074 have been mentioned in the context of this disorder. Affiliated tissues include skull, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Disease Ontology:8 A synostosis that results in premature fusion located in skull.

NIH Rare Diseases:43 Craniosynostosis is a birth defect of the brain characterized by the premature closure of one or more of the joints between the bones of the skull (called the cranial sutures) before brain growth is complete. the first sign is an abnormally shaped skull; other features can include signs of increased intracranial pressure, developmental delays, intellectual disability, seizures, and blindness, caused by constriction of the growing brain. closure of a single suture is most common and does not prevent the brain from expanding to a normal volume. when many sutures close prematurely, the skull cannot expand to accommodate the growing brain, leading to increased pressure and impaired development of the brain. craniosynostosis can be caused by genetic mutations, certain metabolic diseases (such as rickets or an overactive thyroid) or can be associated with other disorders such as microcephaly and hydrocephalus. treatment generally consists of surgery to improve the symmetry and appearance of the head and to relieve pressure on the brain and the cranial nerves. last updated: 3/31/2011

Wikipedia:64 Craniosynostosis (from cranio, cranium; + syn, together; + ostosis relating to bone) is a condition in... more...

Description from OMIM:47 123100,604757,182212

Aliases & Classifications for Craniosynostosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 44NINDS, 10DISEASES, 45Novoseek, 61UMLS, 47OMIM, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

craniosynostosis 8 43 22 44 10 45 61
premature closure of cranial sutures 8
craniostenosis 43
cso 43


External Ids:

Disease Ontology8 DOID:2340
NCIt40 C84655
MeSH35 D003398

Related Diseases for Craniosynostosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the craniosynostosis, type 1 family:

craniosynostosis craniosynostosis, nonsyndromic
craniosynostosis with radiohumeral fusions and other skeletal and craniofacial anomalies craniosynostosis, type 2
craniosynostosis 5 craniosynostosis 3
craniosynostosis 4

Diseases related to Craniosynostosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1muenke syndrome30.6FGFR2, FGFR1, FGFR3, TWIST1
2synostosis30.5TWIST1, MSX2, FGFR3, FGF10, FGFR1, FGFR2
3baller-gerold syndrome30.5RECQL4, TWIST1
4saethre-chotzen syndrome30.4FGFR2, FGFR1, FGFR3, MSX2, TWIST1
5crouzon syndrome30.4MSX2, FGF2, FGFR3, FGFR1, FGFR2
6fgfr-related craniosynostosis syndromes30.3FGFR2, FGFR1, FGFR3
7mental retardation30.3FBN1, FGFR3, TWIST1
8syndactyly30.2FGFR2, FGF8, FGFR3, MSX2
9acrocephalosyndactylia30.2FGFR2, FGFR1, FGF10, FGFR3, FGF2
10jackson-weiss syndrome30.2FGFR2, FGFR1, FGFR3
11infectious mononucleosis30.1FGFR2, FGFR1
12achondroplasia30.0MSX2, FGF9, FGFR3, FGFR2
13skeletal dysplasias30.0FGFR3, FGFR1, FGFR2
14beare-stevenson cutis gyrata syndrome30.0FGFR2
15cleft palate29.9FGFR2, FGFR1, FGF10, TWIST1
16osteoglophonic dysplasia29.7FGFR1
17short stature29.7FGFR3, FBN1
18hypospadias29.7FGFR2, FGF10, FGF8
19dwarfism29.7FGFR3, FGFR1, FGFR2
20polydactyly29.7FGF8, FGFR2
21hypophosphatasia29.7ENPP1
22craniosynostosis, syndromic10.8
23craniosynostosis, nonsyndromic10.6
24fg syndrome10.5
25shprintzen-goldberg syndrome10.4
26n syndrome10.4
27craniosynostosis autosomal dominant10.3
28sleep apnea10.3
29craniosynostosis 510.3
30craniosynostosis philadelphia type10.2
31plagiocephaly10.2
32genoa syndrome10.2
33craniosynostosis, type 210.2
34craniosynostosis 410.2
35micro syndrome10.2
36hunter-mcalpine syndrome10.2
37fgfr3-related craniosynostosis10.2
38craniosynostosis and dental anomalies10.2
39microcephaly10.1
40craniosynostosis, anal anomalies, and porokeratosis10.1
41dandy-walker malformation with sagittal craniosynostosis and hydrocephalus10.1
42goldberg-shprintzen megacolon syndrome10.1
43herrmann opitz craniosynostosis10.1
44craniosynostosis, type 110.1
45craniosynostosis 310.1
46brachydactyly10.1
47rickets10.1
48pycnodysostosis10.1
49holoprosencephaly10.1
50strabismus10.1

Graphical network of the top 20 diseases related to Craniosynostosis:



Diseases related to craniosynostosis

Clinical Features for Craniosynostosis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

123100,604757,182212

Drugs & Therapeutics for Craniosynostosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Craniosynostosis

Drug clinical trials:

Search ClinicalTrials for Craniosynostosis

Search NIH Clinical Center for Craniosynostosis

Search CenterWatch for Craniosynostosis

Genetic Tests for Craniosynostosis

Sources:
22GTR
See all sources

Genetic tests related to Craniosynostosis:

id Genetic test Affiliating Genes
1 Craniosynostosis Syndrome22

Anatomical Context for Craniosynostosis

Sources:
31LifeMap Discovery™, 14FMA
See all sources

FMA organs/tissues related to Craniosynostosis:

14
Skull

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Craniosynostosis:
id TissueAnatomical CompartmentCell Relevance
1 BoneFacial SuturesFacial Presumptive Suture Cells Affected by disease
2 BoneFacial SuturesFacial Suture Cells Affected by disease
3 BoneRostral SuturesRostral Presumptive Suture Cells Affected by disease
4 BoneRostral SuturesRostral Suture Cells Affected by disease

Animal Models for Craniosynostosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Craniosynostosis:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.8ANKH, EFNB1, RECQL4, FGF9, LRP5, MSX2
2MP:000538210.8FBN1, TWIST1, MSX2, LRP5, FGF9, FGFR3
3MP:000537710.8ANKH, EFNB1, FGFR2, FGFR1, FGF10, FGF8
4MP:000539010.8FBN1, NELL1, TWIST1, ENPP1, MSX2, LRP5
5MP:000538110.7EFNB1, RECQL4, FGFR2, FGFR1, FGF10, FGF8
6MP:000538010.7FBN1, RHBDF1, EFNB1, RECQL4, FGFR2, FGFR1
7MP:000537810.7FGFR1, FGFR2, RECQL4, EFNB1, ANKH, RHBDF1
8MP:000536910.7FBN1, ANKH, FGFR1, FGF10, FGF8, FGF9
9MP:001076810.7FGFR1, FGFR2, RECQL4, EFNB1, ANKH, RHBDF1
10MP:000538510.7FGF10, FGFR1, FGFR2, ANKH, FBN1, FGF8
11MP:000539110.7FGFR1, FGFR2, RECQL4, EFNB1, FGF10, FGF8
12MP:000539710.7RECQL4, EFNB1, ANKH, RHBDF1, FBN1, FGFR2
13MP:001077110.7FBN1, RHBDF1, RECQL4, FGFR2, FGFR1, FGF10
14MP:000538610.7FBN1, NELL1, ANKH, FGFR2, FGFR1, FGF8
15MP:000538410.7FGFR1, FGFR2, RECQL4, EFNB1, ANKH, FBN1
16MP:000538710.6FGFR2, RECQL4, EFNB1, ANKH, FBN1, FGFR1
17MP:000363110.6FGF10, FGFR1, FGFR2, EFNB1, FBN1, FGF8
18MP:000537910.6FBN1, FGFR2, FGFR1, MSX2
19MP:000538910.6FBN1, ANKH, EFNB1, FGFR2, FGF10, FGF8
20MP:000538810.5NELL1, ANKH, EFNB1, FGFR2, FGF10, FGFR3
21MP:000287310.4FGFR1, FGF10, FGF8, FGFR3, FGF9, LRP5
22MP:000537610.4FBN1, ANKH, EFNB1, FGFR2, FGF10, FGF8
23MP:000118610.4MSX2
24MP:000536710.1FBN1, ANKH, FGFR2, FGFR1, FGF10, FGF8

Publications for Craniosynostosis

Sources:
51PubMed
See all sources

Articles related to Craniosynostosis:

(show top 50)    (show all 642)
idTitleAuthorsYear
1
New objective measurement of forehead symmetry in unicoronal craniosynostosis - comparison between fronto-orbital advancement and forehead remodelling with a bone graft. (23848422)
2014
2
Age at initial consultation for craniosynostosis: comparison across different patient characteristics. (23348263)
2013
3
Further insights into the genetic basis of craniosynostosis. (24422088)
2013
4
Craniosynostosis. (23960302)
2013
5
The results and complications of cranial bone reconstruction in patients with craniosynostosis. (23851762)
2013
6
Sleep-disordered breathing in children with craniosynostosis. (22535197)
2013
7
Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery. (23371895)
2013
8
Simple and safe head positioning device for repair of craniosynostosis with the patient prone. (23829954)
2013
9
Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis. (23354436)
2013
10
Craniosynostosis: imaging review and primer on computed tomography. (23636536)
2013
11
Strong suggestion of a genetic component in sagittal craniosynostosis. (24422060)
2013
12
Craniosynostosis and deformational plagiocephaly: when and how to intervene. (22866500)
2012
13
A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. (23160099)
2012
14
Changing epidemiology of nonsyndromic craniosynostosis and revisiting the risk factors. (22976622)
2012
15
Neurodevelopmental functioning of infants with untreated single-suture craniosynostosis during early infancy. (22246335)
2012
16
Syndromic craniosynostosis, fibroblast growth factor receptor 2 (FGFR2) mutations, and sacrococcygeal eversion presenting as human tails. (22661218)
2012
17
Deficient language acquisition in children with single suture craniosynostosis and deformational posterior plagiocephaly. (22083136)
2012
18
Endoscopic cranial suture release for the treatment of craniosynostosis--is it the future? (22337414)
2012
19
Reducing blood losses and transfusion requirements in craniosynostosis surgery: an endless quest? (22354246)
2012
20
Unilateral and bilateral expression of a quantitative trait: asymmetry and symmetry in coronal craniosynostosis. (22532473)
2012
21
Craniosynostosis genetics: The mystery unfolds. (22090712)
2011
22
IGF1R variants associated with isolated single suture craniosynostosis. (21204214)
2011
23
Intensive care unit course of infants and children after cranial vault reconstruction for craniosynostosis. (21906303)
2011
24
Posterior cranial vault distraction osteogenesis in craniosynostosis: estimated increases in intracranial volume. (21125285)
2011
25
Differential expression of extracellular matrix-mediated pathways in single-suture craniosynostosis. (22028906)
2011
26
Craniosynostosis associated with neural tube defects: is there a causal association? (22572596)
2011
27
Multidirectional cranial distraction osteogenesis for the treatment of craniosynostosis. (21042126)
2010
28
The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration. (20647499)
2010
29
Evaluation of maxillary permanent molars in patients with syndromic craniosynostosis after monobloc osteotomy and midface advancement with rigid external distraction (RED). (20210632)
2010
30
The incidence of Chiari malformation in nonsyndromic, single suture craniosynostosis. (20013282)
2010
31
Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. (20570969)
2010
32
Rapid palatal expansion in patients with craniosynostosis: a case report. (19893477)
2009
33
The risk of psychopathology in children with craniosynostosis. (19952662)
2009
34
Airway changes following Le Fort III distraction osteogenesis for syndromic craniosynostosis: a clinical and cephalometric study. (19644279)
2009
35
Nonsyndromic craniosynostosis: current treatment options. (18562899)
2008
36
Craniosynostosis and congenital tracheal anomalies in an infant with Pfeiffer syndrome carrying the W290C FGFR2 mutation. (18618990)
2008
37
Recurrence of synostosis following surgical repair of craniosynostosis. (18317088)
2008
38
The Boston-type craniosynostosis mutation MSX2 (P148H) results in enhanced susceptibility of MSX2 to ubiquitin-dependent degradation. (18786927)
2008
39
Craniosynostosis and rickets. (18349605)
2008
40
Superelastic NiTi springs for corrective skull operations in children with craniosynostosis. (17483902)
2007
41
Effectiveness of a limited invasive scalp approach in the correction of sagittal craniosynostosis. (17876586)
2007
42
Statistical shape analysis of metopic craniosynostosis: a preliminary study. (17946220)
2006
43
Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis. (11781872)
2002
44
Craniosynostosis associated with ocular and distal limb defects is very likely caused by mutations in a gene different from FGFR, TWIST, and MSX2. (12407713)
2002
45
Craniosynostosis in transgenic mice overexpressing Nell-1. (12235118)
2002
46
Craniosynostosis in Twist heterozygous mice: a model for Saethre-Chotzen syndrome. (12221714)
2002
47
Monozygotic twins with Crouzon syndrome: concordance for craniosynostosis and discordance for thumb duplication. (10748419)
2000
48
Craniosynostosis: genes and mechanisms. (9300656)
1997
49
Prevalence of Pro250Arg mutation of fibroblast growth factor receptor 3 in coronal craniosynostosis. (9107244)
1997
50
Twenty-year experience with early surgery for craniosynostosis: I. Isolated craniofacial synostosis--results and unsolved problems. (7624400)
1995

Genetic Variations for Craniosynostosis

Expression for genes affiliated with Craniosynostosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Craniosynostosis

Search GEO for disease gene expression data for Craniosynostosis.

Pathways for genes affiliated with Craniosynostosis

Sources:
52QIAGEN, 53R&D Systems, 50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 4Cell Signaling Technology, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Craniosynostosis according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5FGFR3, FGFR1, FGFR2
210.5FGFR3, FGFR1, FGFR2
3
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10.5FGFR2, FGFR1, FGFR3
410.5LRP5
510.5FGF2, FGFR3, FGFR1, FGFR2
6
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10.5FGF2, FGF10, FGFR2
710.5FGFR1, FGFR3, FGF2, ENPP1
810.5EFNB1, FGFR2, FGFR1, FGFR3, FGF2
910.5EFNB1, FGFR2, FGFR1, FGFR3, FGF2
1010.5FGFR2, FGFR1, FGF8, FGFR3, FGF2, MSX2
11
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10.5FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
12
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10.4FGFR2, FGFR1, FGF10, FGF8, FGF9
13
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10.4FBN1, FGFR2, FGFR1, FGF10, FGF8, FGFR3
14
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
15
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
16
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
17
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
18
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
19
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
20
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10.4FGF2, FGFR3, FGF8, FGF10, FGFR1, FGFR2
21
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF2
22
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10.4FGF2, FGFR2, FGFR1, FGF10, FGF8, FGFR3
23
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
24
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
25
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
26
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
27
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
28
Development FGF-family signaling
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
29
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
3010.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
31
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
3210.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
33
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
3410.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
35
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
36
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10.4FBN1, FGFR2, FGFR1, FGF10, FGF8, FGFR3
37
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
38
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10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
3910.4FGFR1, FGF10, FGF8, FGF9, FGF2, TWIST1
40
Hide members
10.4FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
41
Hide members
10.4FBN1, FGFR2, FGFR1, FGF10, FGF8, FGFR3

Compounds for genes affiliated with Craniosynostosis

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Craniosynostosis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1su54024510.8FGF2, FGFR3, FGFR1, FGFR2
2pd 17307445 6011.8FGFR2, FGFR1, FGFR3, FGF2
3pd 1615706010.8FGFR2, FGFR1, FGFR3
4fiin 1 hydrochloride6010.8FGFR2, FGFR1, FGFR3
5su 54026010.8FGFR2, FGFR1, FGFR3
6palifermin45 1111.8FGFR2, FGFR1, FGFR3
7heparan sulfate45 2411.8FBN1, FGFR2, FGFR1, FGF10, FGF8, FGF2
8tyrosine4510.8FBN1, RHBDF1, EFNB1, FGFR2, FGFR1, FGF10
9Ponatinib 1110.8FGFR3, FGFR1, FGFR2
10chondroitin sulfate45 2411.8FBN1, FGFR2, FGFR1, FGF2
11heparin45 29 11 2413.8FBN1, FGFR2, FGFR1, FGF10, FGF8, FGF9
12SU49841110.7FGFR1, FGFR2
13suramin45 29 1112.7FGFR2, FGFR1, FGF8, FGF2
14sucrose octasulfate45 1111.7FGF2, FGFR2
15bromodeoxyuridine4510.7FGFR2, FGFR1, FGF10, FGF2
16vegf4510.7FGFR2, FGFR1, FGF10, FGFR3, FGF9, FGF2
17lysine4510.7FBN1, FGFR2, FGFR1, FGFR3, ENPP1
18calcium45 50 11 2413.6FBN1, ANKH, FGFR2, FGFR1, FGFR3, FGF9
19su66684510.6FGF2, FGFR1
20chlorate4510.6FGFR1, FGF2
21sodium chlorate4510.5FGFR1, FGF2
22sulfate45 2411.5ENPP1, FGFR3, FGFR2
23thalidomide45 50 60 1113.5FGF2, FGFR3, FGFR2
24retinoic acid45 2411.3FBN1, FGFR2, FGFR1, FGF10, FGF8, FGF2
25paclitaxel45 50 1112.2FGFR2, FGFR1, FGF2, TWIST1

GO Terms for genes affiliated with Craniosynostosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Craniosynostosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:01602310.5FGFR3, FGFR1, FGFR2
2extracellular regionGO:00557610.4FGF2, FBN1, NELL1, FGFR2, FGFR1, FGF10
3extracellular spaceGO:00561510.3FBN1, FGF10, FGF8, FGF9, FGF2, ENPP1
4integral to plasma membraneGO:00588710.2ANKH, EFNB1, FGFR2, FGFR1, FGFR3, IL11RA

Biological processes related to Craniosynostosis according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase activityGO:01051810.9FGFR3, FGFR1, FGFR2
2positive regulation of MAPK cascadeGO:04341010.9FGFR2, FGFR1, FGF10, FGFR3, FGF9
3phosphatidylinositol-mediated signalingGO:04801510.9FGF2, FGFR2, FGFR1, FGF10, FGF8, FGFR3
4positive regulation of cardiac muscle cell proliferationGO:06004510.9FGFR2, FGFR1, FGF9, FGF2
5insulin receptor signaling pathwayGO:00828610.9FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
6positive regulation of mesenchymal cell proliferationGO:00205310.9FGFR2, FGFR1, FGF9, LRP5
7fibroblast growth factor receptor signaling pathwayGO:00854310.9FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
8Fc-epsilon receptor signaling pathwayGO:03809510.9FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
9lung-associated mesenchyme developmentGO:06048410.9FGF9, FGFR1, FGFR2
10organ inductionGO:00175910.9FGFR1, FGF10, FGF8, FGF2
11epidermal growth factor receptor signaling pathwayGO:00717310.9FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
12otic vesicle formationGO:03091610.9FGFR2, FGF10, FGF8
13positive regulation of canonical Wnt receptor signaling pathwayGO:09026310.9FGFR2, FGF10, FGFR3, FGF9
14neurotrophin TRK receptor signaling pathwayGO:04801110.9FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
15outflow tract septum morphogenesisGO:00314810.9FGFR2, FGF8, MSX2
16branching involved in salivary gland morphogenesisGO:06044510.9FGFR2, FGFR1, FGF8
17positive regulation of cell proliferationGO:00828410.9FGFR2, FGFR1, FGF8, FGFR3, FGF9, FGF2
18positive regulation of cell divisionGO:05178110.9FGFR2, FGF8, FGF9, FGF2
19bone morphogenesisGO:06034910.9FGFR2, FGFR3, LRP5
20regulation of bone mineralizationGO:03050010.9TWIST1, ENPP1, ANKH
21mesenchymal cell differentiation involved in lung developmentGO:06091510.8FGFR2, FGF10
22positive regulation of ERK1 and ERK2 cascadeGO:07037410.8FGF2, FGFR3, FGF10, FGFR2
23branch elongation involved in salivary gland morphogenesisGO:06066710.8FGFR2, FGF10
24embryonic pattern specificationGO:00988010.8EFNB1, FGFR2, FGF10
25mammary gland bud formationGO:06061510.8FGFR2, FGF10
26innate immune responseGO:04508710.8FGFR2, FGFR1, FGF10, FGF8, FGFR3, FGF9
27fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:06059510.8FGFR2, FGF10
28fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:03560710.8FGFR2, FGFR1
29substantia nigra developmentGO:02176210.8FGFR3, FGF2
30embryonic hindlimb morphogenesisGO:03511610.8FGF8, MSX2, TWIST1
31chondrocyte differentiationGO:00206210.8FGFR1, FGFR3, FGF9
32skeletal system developmentGO:00150110.8FGFR3, FGFR1, ANKH, FBN1
33ventricular zone neuroblast divisionGO:02184710.8FGFR2, FGFR1
34corticotropin hormone secreting cell differentiationGO:06012810.8FGF8, FGF2
35embryonic limb morphogenesisGO:03032610.8LRP5, FGF9, FGFR1
36lacrimal gland developmentGO:03280810.8FGFR2, FGF10
37thyroid-stimulating hormone-secreting cell differentiationGO:06012910.7FGF8, FGF2
38regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.7FGFR1, FGF10
39endochondral bone growthGO:00341610.7FGFR3, MSX2
40peptidyl-tyrosine phosphorylationGO:01810810.7FGFR3, FGFR1, FGFR2
41positive regulation of epithelial cell proliferationGO:05067910.7FGFR2, FGF10, FGF9
42positive regulation of osteoblast differentiationGO:04566910.7NELL1, FGF2, MSX2
43osteoblast differentiationGO:00164910.6FGF9, MSX2, TWIST1
44positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.6FGFR1, FGFR3
45cranial suture morphogenesisGO:06036310.6MSX2, TWIST1
46inner ear morphogenesisGO:04247210.5FGF9, FGFR1, FGFR2
47negative regulation of mitosisGO:04583910.5FGFR3, FGFR2
48angiogenesisGO:00152510.5FGFR2, FGFR1, FGF10, FGF9
49MAPK cascadeGO:00016510.4FGFR3, FGF8, FGFR1
50positive regulation of phospholipase C activityGO:01086310.2FGF2, FGFR1

Molecular functions related to Craniosynostosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:01713410.6FGF2, FGFR3, FGFR1, FGFR2
2fibroblast growth factor receptor bindingGO:00510410.6FGF10, FGF8, FGF9, FGF2
3fibroblast growth factor-activated receptor activityGO:00500710.5FGFR3, FGFR1, FGFR2
4protein tyrosine kinase activityGO:00471310.5FGFR3, FGFR1, FGFR2
5heparin bindingGO:00820110.5FGFR2, FGFR1, FGF10, FGF9, FGF2
6type 2 fibroblast growth factor receptor bindingGO:00511110.4FGF8, FGF10
7growth factor activityGO:00808310.1FGF10, FGF8, FGF9, FGF2

Products for genes affiliated with Craniosynostosis

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Sources for Craniosynostosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet