MCID: CRN113
MIFTS: 39

Craniosynostosis, Syndromic malady

Summaries for Craniosynostosis, Syndromic

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33MalaCards
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MalaCards: Craniosynostosis, Syndromic is related to fgfr-related craniosynostosis syndromes and muenke syndrome. An important gene associated with Craniosynostosis, Syndromic is FBN1 (fibrillin 1), and among its related pathways are FGFR1c and Klotho ligand binding and activation and Sorafenib Pharmacodynamics. The compounds paclitaxel and SU4984 have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Craniosynostosis, Syndromic

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20GeneTests
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Aliases & Descriptions:

craniosynostosis, syndromic 20


Related Diseases for Craniosynostosis, Syndromic

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Craniosynostosis, Syndromic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1fgfr-related craniosynostosis syndromes30.4FGFR3, FGFR1, FGFR2
2muenke syndrome30.2TWIST1, FGFR2, FGFR3, FGFR1
3saethre-chotzen syndrome30.1MSX2, FGFR2, FGFR1, FGFR3, TWIST1
4infectious mononucleosis29.8FGFR1, FGFR2
5jackson-weiss syndrome29.8FGFR2, FGFR3, FGFR1
6acrocephalosyndactylia29.8FGFR1, TWIST1, MSX2, FGFR3, FGFR2
7crouzon syndrome29.8FGF2, FGFR3, FGFR1, FGFR2, MSX2
8synostosis29.8TWIST1, FGFR2, MSX2, FGFR3, FGF10, FGFR1
9shprintzen-goldberg syndrome10.5
10fg syndrome10.4
11n syndrome10.2
12goldberg-shprintzen megacolon syndrome10.2
13auralcephalosyndactyly10.1
14hunter-mcalpine syndrome10.1
15osteoglophonic dysplasia10.0FGFR1
16osteochondroma10.0FGFR3
17beare-stevenson cutis gyrata syndrome10.0FGFR2
18kallmann syndrome 210.0FGFR1
19thyroid cancer10.0FGFR2
20ankylosis10.0ENPP1
21thanatophoric dysplasia10.0FGFR3, FGFR2
22congenital diaphragmatic hernia10.0FGF10
23cleft lip10.0FGFR1, FGF10
24hypochondroplasia10.0FGFR3, FGFR1, FGFR2
25syndactyly10.0FGFR2, MSX2, FGFR3
26cervical cancer10.0FGF10, FGFR3
27dwarfism10.0FGFR2, FGFR1, FGFR3
28skeletal dysplasias10.0FGFR3, FGFR1, FGFR2
29developmental disabilities10.0FGFR1, FGFR3, FGFR2
30pseudoxanthoma elasticum10.0FBN1, ENPP1
31ladd syndrome10.0FGFR3, FGF10, FGFR2
32atopy10.0FLG
33pseudogout10.0ANKH, ENPP1
34achondroplasia10.0MSX2, FGF9, FGFR3, FGFR2
35aorta atresia10.0FGFR2, FGF10
36epidermolysis bullosa10.0FLG
37cleft palate10.0FGFR2, FGFR1, FGF10, TWIST1
38sarcoma10.0FGF7, FGFR4, TWIST1
39endometrial carcinoma10.0FGFR2, FGF7, FGF10
40epidermolysis bullosa dystrophica10.0FLG, FBN1
41calcinosis10.0ENPP1, ANKH, FBN1
42hypophosphatasia10.0ENPP1
43bladder carcinoma10.0FGFR3, FGFR2, FGF2
44embryonal cancer10.0FGFR1, MSX2, FGFR2
45chondrosarcoma10.0FGFR2, FGFR1, FGFR3, FGF2
46pheochromocytoma10.0PLCG1, FRS2
47teratocarcinoma10.0FGFR2, FGF7, FGF2
48stomach cancer10.0TWIST1, FGFR1, FGFR2, FGF7
49osteosarcoma10.0FGF2, TWIST1, FBN1, ENPP1
50pituitary adenoma10.0FGFR4, FGF2, FGFR2

Graphical network of the top 20 diseases related to Craniosynostosis, Syndromic:



Diseases related to craniosynostosis, syndromic

Clinical Features for Craniosynostosis, Syndromic

Drugs & Therapeutics for Craniosynostosis, Syndromic

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Craniosynostosis, Syndromic

Drug clinical trials:

Search ClinicalTrials for Craniosynostosis, Syndromic

Search NIH Clinical Center for Craniosynostosis, Syndromic

Search CenterWatch for Craniosynostosis, Syndromic

Genetic Tests for Craniosynostosis, Syndromic

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20GeneTests
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Genetic tests related to Craniosynostosis, Syndromic:

id Genetic test Affiliating Genes
1 Craniosynostosis, Syndromic20

Anatomical Context for Craniosynostosis, Syndromic

Sources:
33MalaCards
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MalaCards organs/tissues related to Craniosynostosis, Syndromic:

33
Brain

Animal Models for Craniosynostosis, Syndromic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Craniosynostosis, Syndromic:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.9ANKH, FGF9, MSX2
2MP:00053888.7FGF9, FGFR4, FGFR3, FGF10, FGFR2, ANKH
3MP:00053778.4MSX2, FLG, ANKH, FGF10, FGFR3, FGF9
4MP:00053818.2FGFR2, FGFR1, FGF10, FGFR3, FGF9, PLCG1
5MP:00053898.1FBN1, ANKH, FGFR2, FGF10, FGF7, FGFR3
6MP:00053698.0FBN1, ANKH, FGFR1, FGF10, FGF9, FGF2
7MP:00107717.9FBN1, RHBDF1, FGFR2, FGFR1, FGF10, FGF9
8MP:00053917.8FGFR2, FGFR1, FGF10, FGFR3, FGF9, FGF2
9MP:00053677.8FBN1, ANKH, FGFR2, FGFR1, FGF10, FGF7
10MP:00053907.6FBN1, ANKH, FGFR2, FGFR1, FGF10, FGFR3
11MP:00053807.4FBN1, RHBDF1, FGFR2, FGFR1, FGF10, FRS2
12MP:00053827.4FBN1, FLG, ANKH, FGFR2, FGFR1, FGF10
13MP:00053867.0FBN1, ANKH, FGFR2, FGFR1, FGF7, FGFR3
14MP:00053846.9FGFR1, FGFR2, ANKH, FLG, FBN1, FGF10
15MP:00053876.7FGFR2, ANKH, FLG, FBN1, FGFR1, FGF10
16MP:00036316.7FGF10, FGFR1, FGFR2, FBN1, FGF7, FGFR3
17MP:00053856.6FGF10, FGFR1, FGFR2, ANKH, FBN1, FGF9
18MP:00053766.4FBN1, FLG, ANKH, FGFR2, FGF10, FGF7
19MP:00053976.4FBN1, FLG, RHBDF1, ANKH, FGFR2, FGF10
20MP:00053785.7FGFR1, FGFR2, ANKH, RHBDF1, FLG, FBN1
21MP:00107685.2FGF10, FGFR1, FGFR2, ANKH, RHBDF1, FLG

Publications for Craniosynostosis, Syndromic

Sources:
51PubMed
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Articles related to Craniosynostosis, Syndromic:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Orbital aspects following monobloc advancement in syndromic craniosynostosis. (23352809)
2013
2
Adenotonsillectomy for obstructive sleep apnea in children with syndromic craniosynostosis. (23542256)
2013
3
Cranial vault growth in multiple-suture nonsyndromic and syndromic craniosynostosis: a postoperative long-term anthropometric follow-up. (23714873)
2013
4
Soft-tissue profile changes following early Le Fort III distraction in growing children with syndromic craniosynostosis. (24076685)
2013
5
Evidence for long-term effectiveness of cranial distraction osteogenesis for syndromic craniosynostosis. (23664382)
2013
6
Psychosocial outcomes in children with and without non-syndromic craniosynostosis: findings from two studies. (22315944)
2013
7
Orbital volume and surface after Le Fort III advancement in syndromic craniosynostosis. (22565907)
2012
8
Fronto-facial monobloc distraction in syndromic craniosynostosis. Three-dimensional evaluation of treatment outcome and facial growth. (22094394)
2012
9
Syndromic craniosynostosis, fibroblast growth factor receptor 2 (FGFR2) mutations, and sacrococcygeal eversion presenting as human tails. (22661218)
2012
10
A novel craniofacial osteogenesis distraction system enabling control of distraction distance and vector for the treatment of syndromic craniosynostosis. (22421842)
2012
11
Asymmetric laterality of Chiari type I malformation in patients with non-syndromic single-suture craniosynostosis. (22955872)
2012
12
Does central sleep apnea occur in children with syndromic craniosynostosis? (22484378)
2012
13
Resolution of syndromic craniosynostosis-associated Chiari malformation Type I without suboccipital decompression after posterior cranial vault release. (22295912)
2012
14
Volumetric analysis of anterior versus posterior cranial vault expansion in patients with syndromic craniosynostosis. (22421838)
2012
15
Simultaneous and differential fronto-orbital and midface distraction osteogenesis for syndromic craniosynostosis using rigid external distractor II. (22976628)
2012
16
Long-term follow-up of syndromic craniosynostosis after Le Fort III halo distraction: a cephalometric and CT evaluation. (22227504)
2012
17
Health-related problems and quality of life in patients with syndromic and complex craniosynostosis. (22234545)
2012
18
Unique sex-based approach identifies transcriptomic biomarkers associated with non-syndromic craniosynostosis. (22654505)
2012
19
Syndromic craniosynostosis in a modern-age skeleton from Siena, Italy. (21959423)
2011
20
Tracheobronchial anomalies in syndromic craniosynostosis with 3-dimensional CT image and bronchoscopy. (21959391)
2011
21
Assessment of white matter microstructural integrity in children with syndromic craniosynostosis: a diffusion-tensor imaging study. (21852568)
2011
22
Posterior cranial vault expansion performed with rapid distraction and time-reduced consolidation in infants with syndromic craniosynostosis. (21863295)
2011
23
Are ultrasonography measurements of optic nerve sheath diameter an alternative to funduscopy in children with syndromic craniosynostosis? (21882928)
2011
24
Sleep-related disordered breathing in children with syndromic craniosynostosis. (20627744)
2011
25
Audiological profile of children and young adults with syndromic and complex craniosynostosis. (21844411)
2011
26
Long-term functional outcome in 167 patients with syndromic craniosynostosis; defining a syndrome-specific risk profile. (19913472)
2010
27
Evaluation of maxillary permanent molars in patients with syndromic craniosynostosis after monobloc osteotomy and midface advancement with rigid external distraction (RED). (20210632)
2010
28
Syndromic craniosynostosis: complicated airway obstruction calls for progressive strategies in surgical management. (20524914)
2010
29
Obstructive sleep apnea in children with syndromic craniosynostosis: long-term respiratory outcome of midface advancement. (20056390)
2010
30
Three-dimensional airway changes after Le Fort III advancement in syndromic craniosynostosis patients. (20679838)
2010
31
Role of parental risk factors in the aetiology of isolated non-syndromic metopic craniosynostosis. (20510490)
2010
32
Evaluation of cephalometric points in midface bone lengthening with the use of a rigid external device in syndromic craniosynostosis patients. (19649491)
2009
33
Reossification of cranium and zygomatic arch after monobloc frontofacial distraction advancement for syndromic craniosynostosis. (19816373)
2009
34
Airway changes following Le Fort III distraction osteogenesis for syndromic craniosynostosis: a clinical and cephalometric study. (19644279)
2009
35
Genotypic and phenotypic analyses of Korean patients with syndromic craniosynostosis. (19624690)
2009
36
Adenotonsillectomy for sleep-disordered breathing in children with syndromic craniosynostosis. (19881386)
2009
37
Comparison of periodontal parameters in individuals with syndromic craniosynostosis. (19148400)
2009
38
A new case of syndromic craniosynostosis with cryptic 19p13.2-p13.13 deletion. (19842200)
2009
39
Longitudinal assessment of visual development in non-syndromic craniosynostosis: a 1-year pre- and post-surgical study. (18463123)
2008
40
Clinical features of syndromic craniosynostosis. (18391497)
2008
41
Morphometric analysis of untreated adult skulls in syndromic and nonsyndromic craniosynostosis. (17992550)
2008
42
Lateral orbital expansion and gradual fronto-orbital advancement: an option to treat severe syndromic craniosynostosis. (19098565)
2008
43
The role of the nasopharyngeal airway for obstructive sleep apnea in syndromic craniosynostosis. (18520380)
2008
44
Syndromic craniosynostosis: from history to hydrogen bonds. (17552943)
2007
45
Syndromic craniosynostosis due to complex chromosome 5 rearrangement and MSX2 gene triplication. (18000908)
2007
46
Visual function in infants with non-syndromic craniosynostosis. (17635200)
2007
47
Genetic analysis of non-syndromic craniosynostosis. (17651129)
2007
48
Syndromic craniosynostosis with elbow joint contracture. (16465081)
2006
49
Visual loss in syndromic craniosynostosis with papilledema but without other symptoms of intracranial hypertension. (15547395)
2004
50
A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) causes non-syndromic craniosynostosis. (10914960)
2000

Genetic Variations for Craniosynostosis, Syndromic

Expression for genes affiliated with Craniosynostosis, Syndromic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Craniosynostosis, Syndromic

Search GEO for disease gene expression data for Craniosynostosis, Syndromic.

Pathways for genes affiliated with Craniosynostosis, Syndromic

Sources:
54Reactome, 50PharmGKB, 52QIAGEN, 60Tocris Bioscience, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Craniosynostosis, Syndromic according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9FGFR4, FGFR1
2
Hide members
9.5FGFR2, FGFR1, FGFR3, FGFR4
39.5FGFR2, FGFR1, FGFR3, FGFR4
4
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9.5FGFR4, FGFR3, FGFR1, FGFR2
59.5FGFR4, FGFR3, FGFR1, FGFR2
6
Hide members
9.5FGFR4, FGFR3, FGFR1, FGFR2
7
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9.4FGFR2, FGF10, PLCG1
8
Hide members
9.4FRS2, FGF2
99.3FGFR2, FGF2, PLCG1
109.2FGFR1, FGFR3, FGF2, ENPP1
119.2FGFR1, FGF2, FRS2
129.0FGFR2, FGFR1, FGFR3, FGFR4, FGF2
13
Hide members
9.0FGFR2, FGFR1, FGFR3, FGFR4, PLCG1
148.8FGFR2, FGFR1, FGFR3, FGF2, MSX2, TWIST1
15
Hide members
8.7FGF2, FGF7, FGF10, FGFR2
168.6FGFR2, FGFR1, FGFR4, FRS2, PLCG1
178.5FGFR2, FGFR1, FGFR3, FGFR4, FGF2, PLCG1
188.4FGFR2, FGFR1, FGFR3, FGFR4, FGF2, FRS2
19
Hide members
8.3FGFR2, FGFR1, FGF10, FGF7, FGFR4, FGF9
20
Hide members
8.1FGF9, FGFR4, FGFR3, FGF7, FGF10, FGFR1
21
Hide members
7.9FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
22
Hide members
7.6FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
23
Hide members
7.6FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
247.6FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
257.4FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGF9
26
Hide members
7.4FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGF9
27
Hide members
7.4FGF2, FGFR4, FGFR3, FGF7, FGF10, FGFR1
28
Hide members
7.4FGFR2, PLCG1, FGF2, FGFR4, FGFR3, FGF7
29
Hide members
7.4FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
30
Hide members
7.4FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
31
Hide members
7.4FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
32
Hide members
7.4FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
33
Hide members
7.1FBN1, FGFR2, FGFR1, FGF10, FGF7, FGFR3
34
Hide members
7.1FBN1, FGFR2, FGFR1, FGF10, FGF7, FGFR3
35
Hide members
7.1FGF2, PLCG1, FGF9, FGFR4, FGFR3, FGFR2
36
Hide members
7.1FGFR2, FGFR1, PLCG1, FGF2, FGF9, FGFR4
37
Hide members
7.1FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
38
Hide members
7.0FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
39
Hide members
7.0FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
40
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7.0FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
417.0FGFR1, FGF10, FGF7, FGF9, FGF2, FRS2
42
Hide members
6.5FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
43
Hide members
6.5FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
44
Development FGF-family signaling
Hide members
6.5PLCG1, FGFR2, FGFR1, FGF10, FGF7, FGFR3
45
Hide members
6.5FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
466.5FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
47
Hide members
6.5FGF2, FRS2, PLCG1, FGF9, FGFR4, FGFR3
48
Hide members
6.2FBN1, FGFR2, FGFR1, FGF10, FGF7, FGFR3

Compounds for genes affiliated with Craniosynostosis, Syndromic

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Craniosynostosis, Syndromic according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1paclitaxel45 50 1112.5FGFR2
2SU49841110.4FGFR2, FGFR1
3sucrose octasulfate45 1111.2FGF2, FGFR2
4su66684510.1FGF2, FGFR1
5chlorate4510.1FGFR1, FGF2
6sodium chlorate4510.1FGFR1, FGF2
7pd 161570609.9FGFR2, FGFR1, FGFR3, FGFR4
8fiin 1 hydrochloride609.9FGFR2, FGFR1, FGFR3, FGFR4
9su 5402609.9FGFR2, FGFR1, FGFR3, FGFR4
10Ponatinib 119.9FGFR4, FGFR3, FGFR1, FGFR2
11thalidomide45 50 60 1112.9FGFR2, FGFR3, FGF2
12su5402459.8FGFR2, FGFR1, FGFR3, FGF2
13dextran sulfate sodium459.7FGF7, FGF10
14lysine459.6FBN1, FGFR2, FGFR1, FGFR3, ENPP1
15phenylalanine459.5FGFR2, FGFR1, FGFR3, FRS2
16pd 17307445 6010.5FGFR2, FGFR1, FGFR3, FGFR4, FGF2
17sodium dodecylsulfate459.4PLCG1, FGF2, FBN1
18amifostine45 1110.4ENPP1, FGF7
19polysaccharide459.4PLCG1, FGF2, FGFR1, FGFR2
20dexamethasone45 50 29 1112.3FGF2, PLCG1, ENPP1
21latex459.2FLG, FGFR2, FGF7
22sulfate45 2410.2ENPP1, FGFR3, FGF7, FGFR2
23protamine sulfate459.2FGF2, FGF7
24polyglycolic acid459.2FGF2, FGF7
25glycosaminoglycan459.2FGFR2, FGF7, FGF2
26suramin45 29 1111.1FGF2, FGF7, FGFR1, FGFR2
27palifermin45 1110.1FGFR2, FGFR1, FGF7, FGFR3, FGFR4
28vitamin d459.0PLCG1, FGF7, FGFR2, FBN1
29gf 109203x45 6010.0FLG, FGF2, PLCG1
30paraffin459.0FGF2, FGFR4, FGFR3, FGFR2
31arginine458.9FBN1, FLG, FGFR2, FGFR3, FGFR4, PLCG1
32chondroitin sulfate45 249.9FBN1, FGFR2, FGFR1, FGF7, FGF2
33pd 98,059458.9FGF2, FGF7, FGFR1, FGFR2
34oligonucleotide458.9MSX2, FGFR3, FGF7, FGFR1, FGFR2
35steroid458.8FLG, FGFR2, FGFR1, FGF7, MSX2
36heparin45 29 11 2411.8FBN1, FGF10, FGF7, FGF9, PLCG1
37phosphotyrosine458.8FGFR2, FGFR1, FGFR3, FGFR4, FRS2, PLCG1
38lipid458.7FBN1, FLG, FGFR2, FGFR1, FGFR3, PLCG1
39agar458.6FGFR2, FGFR1, FGF7, FGF2, PLCG1
40genistein45 29 60 2 11 2413.6FGFR2, FGFR1, FGF7, FGF2, PLCG1
41h2o2458.5FGFR2, FGFR1, FGF7, FGF2, PLCG1
42bromodeoxyuridine458.4FLG, FGFR2, FGFR1, FGF10, FGF7, FGF2
43heparan sulfate45 249.3FBN1, FGFR2, FGFR1, FGF10, FGF7, FGFR4
44cysteine458.2FBN1, FLG, FGFR2, FGFR1, FGF7, FGFR3
45phosphatidylinositol458.0FGFR2, FGFR1, FGF7, FGFR4, FGF2, PLCG1
46retinoic acid45 248.7FBN1, FLG, FGFR2, FGFR1, FGF10, FGF7
47serine457.6FBN1, FLG, FGF7, FGFR3, FGF2, FRS2
48vegf457.5FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
49calcium45 50 11 2410.0FBN1, FLG, ANKH, FGFR2, FGFR1, FGF7
50tyrosine455.6TWIST1, FBN1, FLG, RHBDF1, FGFR2, FGFR1

GO Terms for genes affiliated with Craniosynostosis, Syndromic

Sources:
16Gene Ontology
See all sources

Cellular components related to Craniosynostosis, Syndromic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.3FLG, FGFR2, FGFR1, FGFR3
2integral to plasma membraneGO:0058878.2ANKH, FGFR2, FGFR1, FGFR3, FGFR4, FRS2
3extracellular regionGO:0055767.4FGF2, FBN1, FGFR2, FGFR1, FGF10, FGF7
4plasma membraneGO:0058867.3FGFR2, FGFR1, FGF10, FGFR3, FGFR4, FRS2

Biological processes related to Craniosynostosis, Syndromic according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:03560710.4FGFR2, FGFR1
2ventricular zone neuroblast divisionGO:02184710.3FGFR1, FGFR2
3branch elongation involved in salivary gland morphogenesisGO:06066710.3FGFR2, FGF10
4mesenchymal cell differentiation involved in lung developmentGO:06091510.3FGF10, FGFR2
5alveolar secondary septum developmentGO:06114410.3FGFR4, FGFR3
6mammary gland bud formationGO:06061510.3FGFR2, FGF10
7fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:06059510.3FGFR2, FGF10
8lacrimal gland developmentGO:03280810.2FGF10, FGFR2
9positive regulation of phospholipase activityGO:01051810.2FGFR2, FGFR1, FGFR3
10endochondral bone growthGO:00341610.2FGFR3, MSX2
11lung-associated mesenchyme developmentGO:06048410.1FGF9, FGFR1, FGFR2
12substantia nigra developmentGO:02176210.1FGFR3, FGF2
13chondrocyte differentiationGO:00206210.0FGFR1, FGFR3, FGF9
14positive regulation of mesenchymal cell proliferationGO:00205310.0FGFR2, FGFR1, FGF9
15negative regulation of mitosisGO:04583910.0FGFR3, FGFR2
16positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:09008010.0FGFR1, FGFR3
17regulation of bone mineralizationGO:0305009.9ANKH, ENPP1, TWIST1
18peptidyl-tyrosine phosphorylationGO:0181089.9FGFR2, FGFR1, FGFR3, FGFR4
19cranial suture morphogenesisGO:0603639.9MSX2, TWIST1
20osteoblast differentiationGO:0016499.8FGF9, MSX2, TWIST1
21inner ear morphogenesisGO:0424729.8FGFR2, FGFR1, FGF9
22positive regulation of canonical Wnt receptor signaling pathwayGO:0902639.8FGFR2, FGF10, FGFR3, FGF9
23protein autophosphorylationGO:0467779.8FGFR2, FGFR1, FGFR3, FGFR4
24skeletal system developmentGO:0015019.7FGFR3, FGFR1, ANKH, FBN1
25positive regulation of cardiac muscle cell proliferationGO:0600459.7FGF2, FGF9, FGFR1, FGFR2
26positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:0605019.7FGF7, FGFR2
27secretion by lung epithelial cell involved in lung growthGO:0610339.7FGF7, FGF10
28positive regulation of MAPK cascadeGO:0434109.6FGFR2, FGFR1, FGF10, FGFR3, FGF9
29branching involved in salivary gland morphogenesisGO:0604459.6FGF7, FGFR1, FGFR2
30positive regulation of keratinocyte migrationGO:0515499.6FGF10, FGF7
31angiogenesisGO:0015259.6FGF9, FGF10, FGFR1, FGFR2
32positive regulation of keratinocyte proliferationGO:0108389.6FGF10, FGF7
33regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.5FGF7, FGF10, FGFR1
34hair follicle morphogenesisGO:0310699.5FGFR2, FGF10, FGF7
35positive regulation of phospholipase C activityGO:0108639.5FGF2, FGFR1
36positive regulation of ERK1 and ERK2 cascadeGO:0703749.4FGFR2, FGF10, FGFR3, FGFR4, FGF2
37in utero embryonic developmentGO:0017019.3TWIST1, PLCG1, FGFR1, FGFR2
38positive chemotaxisGO:0509189.3FGF2, FGF7, FGF10
39positive regulation of epithelial cell proliferationGO:0506799.2FGFR2, FGF10, FGF7, FGF9
40activation of MAPKK activityGO:0001869.1FGF2, FRS2, PLCG1
41positive regulation of cell divisionGO:0517819.1FGF2, FGF9, FGF7, FGFR2
42organ inductionGO:0017599.0FGFR1, FGF10, FGFR4, FGF2, FRS2
43positive regulation of cell proliferationGO:0082848.3FGFR2, FGFR1, FGF7, FGFR3, FGFR4, FGF9
44phosphatidylinositol-mediated signalingGO:0480157.4FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
45insulin receptor signaling pathwayGO:0082867.4FGFR3, FGFR4, FGF9, FGF2, FRS2, FGF7
46Fc-epsilon receptor signaling pathwayGO:0380956.9FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
47epidermal growth factor receptor signaling pathwayGO:0071736.9FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4
48fibroblast growth factor receptor signaling pathwayGO:0085436.9PLCG1, FRS2, FGF2, FGFR2, FGFR1, FGF10
49neurotrophin TRK receptor signaling pathwayGO:0480116.9FGF7, FGF10, FGFR1, FGFR2, FGFR3, FGFR4
50innate immune responseGO:0450876.9FGFR2, FGFR1, FGF10, FGF7, FGFR3, FGFR4

Molecular functions related to Craniosynostosis, Syndromic according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:0050079.6FGFR4, FGFR3, FGFR1, FGFR2
2protein tyrosine kinase activityGO:0047139.5FGFR2, FGFR1, FGFR3, FGFR4
3fibroblast growth factor bindingGO:0171349.2FGFR2, FGFR1, FGFR3, FGFR4, FGF2
4neurotrophin TRKA receptor bindingGO:0051689.0PLCG1, FRS2
5chemoattractant activityGO:0420568.9FGF2, FGF7, FGF10
6growth factor activityGO:0080838.5FGF10, FGF7, FGF9, FGF2
7fibroblast growth factor receptor bindingGO:0051048.1FGF10, FGF7, FGF9, FGF2, FRS2
8heparin bindingGO:0082018.0FGF2, FGF9, FGFR4, FGF7, FGF10, FGFR1
9protein bindingGO:0055156.3FGFR2, FGFR1, FGF7, FGFR3, FGF2, FRS2

Products for genes affiliated with Craniosynostosis, Syndromic

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Sources for Craniosynostosis, Syndromic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet