Creatine Phosphokinase malady

Wikipedia: Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phospho-creatine kinase (and...⁴⁴ more...

MalaCards: Creatine Phosphokinase is related to creatine phosphokinase, elevated serum and ectopic pregnancy. An important gene associated with Creatine Phosphokinase is CAV3 (caveolin 3), and among its related pathways are Arginine and proline metabolism and Metabolism of amino acids and derivatives. The compounds glucose and phosphocreatine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and smooth muscle, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

creatine phosphokinase 7

Diseases related to creatine phosphokinase by text searches and GeneDecks gene sharing:

(show top 50)    (show all 260)

id	Related Disease	Score	Top Affiliating Genes
1	creatine phosphokinase, elevated serum	31.8	PIK3C2A, CHKB, MB, CAV3, HMGCR
2	ectopic pregnancy	31.1	PIK3C2A, CHKB, MYH11
3	syncope	29.9	PIK3C2A, CHKB, MB, CAV3
4	muscular dystrophy	29.9	PIK3C2A, CKM, CHKB, CAV3
5	necrotizing fasciitis	29.5	PIK3C2A, GPT
6	cramps	29.1	PIK3C2A, MB, GPT, AFP
7	neuroleptic malignant syndrome	28.9	PIK3C2A, CHKA, CHKB, MB, GPT
8	acute myocardial infarction	28.9	PIK3C2A, CKM, CHKA, CHKB, MB, GPT
9	myocardial infarction	28.6	PIK3C2A, CKM, CKMT1B, CHKA, CHKB, MB
10	spinal cord injury	28.0	PIK3C2A, GPT, ALPP, SOD1, SLPI
11	seizures	28.0	PIK3C2A, CHKB, MB, ALPP, GLUL, HMGCR
12	acne	27.6	PIK3C2A, CHKB, ALPP, HSD17B13, SOD1, SLPI
13	meningitis	27.2	PIK3C2A, CHKB, MB, GLUL, SOD1, SLC17A5
14	cerebritis	26.9	PIK3C2A, CHKA, CHKB, MB, ALPP, GLUL
15	crohn's disease	26.1	PIK3C2A, GPT, ALPP, SOD1, SLPI, SLC17A5
16	hypoxia	24.5	PIK3C2A, CHKA, CHKB, MB, ENO3, GPT
17	myopathy	24.4	PIK3C2A, CKM, CHKA, CHKB, MB, ENO3
18	short-chain acyl-coa dehydrogenase deficiency	13.5	PIK3C2A, CHKA
19	adult dermatomyositis	13.5	PIK3C2A, CHKB
20	acute kidney tubular necrosis	13.5	PIK3C2A, MB
21	prostate rhabdomyosarcoma	13.4	CKM, CKMT1B
22	gas gangrene	13.4	PIK3C2A, CHKB, MB
23	cocaine abuse	13.4	PIK3C2A, CHKB, MB
24	bronchiolitis obliterans organizing pneumonia	13.3	PIK3C2A, CHKA
25	compartment syndrome	13.3	CHKA, CHKB, MB
26	neuromuscular disease	13.3	CHKB, MB, CAV3
27	lymphocytic hypophysitis	13.2	ENO3, ALPP
28	ullrich congenital muscular dystrophy	13.2	PIK3C2A, CHKA, CHKB
29	malignant sertoli cell tumor	13.2	ALPP, AFP
30	extragonadal germ cell tumor	13.2	SLPI, AFP
31	glutathione synthetase deficiency	13.1	GLUL, GGT1
32	congestive heart failure	13.1	PIK3C2A, CHKB, HMGCR
33	obstructive jaundice	13.1	ALPP, GGT1
34	muscle disorders	13.1	CHKA, CHKB, ENO3, CAV3
35	bacteremia, protection against	13.1	HMGCR, SLPI
36	aagenaes syndrome	13.1	ALPP, GGT1
37	distal muscular dystrophy	13.1	PIK3C2A, CAV3
38	hepatic tuberculosis	13.1	ALPP, GGT1
39	mature teratoma	13.1	ALPP, AFP
40	coronary artery anomaly	13.0	PIK3C2A, CHKB, MB, HMGCR
41	alcoholic liver cirrhosis	13.0	GPT, AFP
42	hypoparathyroidism	13.0	PIK3C2A, ALPP, SLPI
43	bronchiolitis obliterans	13.0	PIK3C2A, CHKA, CHKB, SLPI
44	duchenne muscular dystrophy	13.0	PIK3C2A, CKM, CHKB, MB, CAV3
45	intermediate coronary syndrome	13.0	PIK3C2A, MB
46	acute intermittent porphyria	12.9	GLUL, SOD1
47	reye syndrome	12.8	GPT, GLUL, HMGCR
48	extrahepatic cholestasis	12.8	GPT, GGT1
49	malignant hyperthermia	12.8	PIK3C2A, CHKB, MB, GPT
50	amenorrhea	12.8	ALPP, HSD17B13, AFP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to creatine phosphokinase:

²²

MGI Mouse Phenotypes related to creatine phosphokinase:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	7.5	GGT1, AFP, SLC17A5, HMGCR, GLUL, MB
2	homeostasis/metabolism phenotype	MP:0005376	5.3	PIK3C2A, MYH11, GGT1, AFP, SLC17A5, SLPI

Articles related to creatine phosphokinase:

(show top 50)    (show all 52)

id	Title	Authors	Year	Affiliating Genes
1	Daptomycin exposure and the probability of elevations in the creatine phosphokinase level: data from a randomized trial of patients with bacteremia and endocarditis. (20462352)	Bhavnani S.M.... Drusano G.L.	2010	PIK3C2A
2	Serum creatine phosphokinase is helpful in distinguis hing generalized tonic-clonic seizures from psychogenic nonepileptic seizures a nd vasovagal syncope. (19383552)	Petramfar P.... Asadi-Pooya A.A.	2009	PIK3C2A
3	Elevation of serum creatine phosphokinase in hospital ized patients. (19773643)	Amir K.A.... Arsura E.L.	2009	PIK3C2A
4	Elevated creatine phosphokinase levels associated wit h linezolid therapy. (19498124)	Allison G.W.... Angelis S.M.	2009	PIK3C2A
5	Creatine phosphokinase values during isotretinoin treatment for acne. (18377609)	Kaymak Y.	2008	GGT1, PIK3C2A, SLPI
6	Serum creatine phosphokinase activity and histological changes in the multifidus muscle: a prospective randomized controlled comparative study of discectomy with or without retraction. (17330578)	Kotil K.... Bilge T.	2007	PIK3C2A
7	Serum creatine phosphokinase as an indicator of muscle injury after various spinal and nonspinal surgical procedures. (17877261)	Arts M.P.... Peul W.C.	2007	PIK3C2A
8	Perioperative creatine phosphokinase (CPK) and troponin I trends after elective hip surgery. (17693841)	Mouzopoulos G.... Safioleas M.	2007	PIK3C2A
9	New physiological model of serum creatine phosphokinase activity in acute myocardial infarction. Estimation of the total creatine phosphokinase release. (18002105)	Kitawaki T.... Himeno R.	2007	PIK3C2A
10	Effect of pH on the adsorption and activity of creatine phosphokinase. (16471871)	Pancera S.M.... Petri D.F.	2006	PIK3C2A
11	HMG-CoA reductase inhibitors (statins) might cause hi gh elevations of creatine phosphokinase (CK) in patients with unnoticed hypothy roidism. (16723812)	Tokinaga K.... Matsushima Y.	2006	HMGCR
12	Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. (16389014)	Katsikis I.... Panidis D.	2006	PIK3C2A
13	Serum creatine phosphokinase monitoring in patients i nfected with HIV. (16409682)	Piscopo T.V.... Miller A.R.	2006	PIK3C2A
14	Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. (15213044)	Da Costa K.A.... Zeisel S.H.	2004	PIK3C2A
15	The predictive value of creatine phosphokinase and alkaline phosphatase in identification of heterotopic ossification in patients after spinal cord injury. (14639555)	Singh R.S.... Mountz J.M.	2003	ALPP, PIK3C2A
16	Value of measurements of the serum activities of creatine phosphokinase, aspartate aminotransferase and lactate dehydrogenase for predicting whether recumbent dairy cows will recover. (12846288)	Shpigel N.Y.... Bogin E.	2003	PIK3C2A, SLC17A5
17	Serum levels of myoglobin, creatine phosphokinase, and smooth muscle heavy-chain myosin in patients with ectopic pregnancy. (11719740)	Birkhahn R.H.... Nagai R.	2001	MYH11
18	The importance of serum creatine phosphokinase level in the early diagnosis, and as a prognostic factor, of Vibrio vulnificus infection. (11531792)	Nakafusa J.... Narisawa Y.	2001	PIK3C2A
19	Incidence and risk factors of benign creatine phosphokinase elevations in chronic psychiatric patients. (10343181)	Terao T.... Etoh A.	1999	PIK3C2A
20	The usefulness of determining myoglobin, creatine phosphokinase MB isoenzyme, lactate dehydrogenase and aspartate aminotransferase in the diagnosis of acute myocardial infarct (9810342)	JuA!rez U.... Reyes P.A.	1998	MB
21	Does muscle creatine phosphokinase have access to the total pool of phosphocreatine plus creatine? (9530257)	Hochachka P.W.... Mossey M.K.	1998	PIK3C2A
22	Recurrence pattern of serum creatine phosphokinase levels in repeated acute psychosis. (9513739)	Manor I.... Weizman A.	1998	PIK3C2A
23	Increase in serum creatine phosphokinase concentrations after suxamethonium during sevoflurane or isoflurane anaesthesia in children. (9135354)	Kudoh A.... Matsuki A.	1997	GPT, SLC17A5
24	Mobility of creatine phosphokinase and beta-enolase in cultured muscle cells. (9370460)	Arrio-Dupont M.... Cribier S.	1997	ENO3
25	Sperm plasma membrane remodeling during spermiogenetic maturation in men: relationship among plasma membrane beta 1,4-galactosyltransferase, cytoplasmic creatine phosphokinase, and creatine phosphokinase isoform ratios. (9096886)	Huszar G.... Shur B.D.	1997	CKM, CHKA
26	Creatine phosphokinase elevation in patients presenting to the emergency department with cocaine-related complaints. (9148972)	Counselman F.L.... Bhambhani-Bhavnani A.S.	1997	PIK3C2A
27	Creatine phosphokinase activity in cerebrospinal fluid in purulent meningitis (9091952)	Pancewicz S.A.	1996	PIK3C2A
28	Increase of serum creatine phosphokinase in catatonia : an investigation in 32 acute catatonic patients. (8733213)	Northoff G.... Pflug B.	1996	PIK3C2A
29	On the mechanism of the inhibition of glutamine synthetase and creatine phosphokinase by methionine sulfoxide. (8838581)	Haghighi A.Z.... Maples K.R.	1996	SOD1, GLUL, PIK3C2A
30	Creatine phosphokinase-linked immunoglobulin associated with hypokalemic myopathy. (8929653)	Hoshino J.... Murata K.	1995	PIK3C2A
31	The peak of creatine phosphokinase level in the acute phase of myocardial infarction in patients with and without ischemic precedents (7609890)	Trappolini M.... Puletti M.	1995	CHKB
32	Effects of physical activity on creatine phosphokinase and the isoenzyme creatine kinase-MB. (7710160)	Schneider C.M.... Hayward J.R.	1995	PIK3C2A
33	Muscle cramps and elevated serum creatine phosphokinase levels induced by beta-adrenoceptor blockers. (7621844)	Imai Y.... Abe K.	1995	PIK3C2A
34	The roles of myoglobin, MB iso-enzyme of creatine phosphokinase and aspartate aminotransferase in serum in the acute phase of myocardial infarction. (7930658)	Mehta S.... Mehta S.R.	1994	MB
35	Perioperative creatine phosphokinase trends in elderly patients with hip fracture. (8200775)	Kaar T.K.... Mullen G.B.	1994	PIK3C2A
36	A biochemical study of creatine phosphokinase in the myocardium and its morphological changes in patients with acute vascular surgi cal pathology (8139171)	Trusov O.A.... Tsareva L.A.	1993	PIK3C2A
37	Incomplete development of human spermatozoa is associated with increased creatine phosphokinase concentration and abnormal head morphology. (8471251)	Huszar G.... Vigue L.	1993	CHKA
38	Role of creatine phosphokinase in predicting acute renal failure in hypocalcemic exertional heat stroke. (1481873)	Shieh S.D.... Diang L.K.	1992	PIK3C2A
39	A complicated case of exertional heat stroke in a military setting with persistent elevation of creatine phosphokinase. (1603384)	Brown J.... Mitchell S.	1992	PIK3C2A
40	Correlation of creatine phosphokinase blood level with prenatal fetal heart rate as a prognostic factor in tissue hypoxia (1398197)	JimAcnez Solis G.... ZA!rate TreviA+o A.	1992	PIK3C2A
41	Creatine phosphokinase in a hospitalized psychiatric population (1362345)	Manero MarcAcn E.... Pinilla Tubet E.	1992	PIK3C2A
42	Cerebral vasospasm with elevated creatine phosphokinase following surgery of unruptured arteriovenous malformation. (1603219)	Takabatake Y.... Yamamoto Y.	1992	PIK3C2A
43	Bull-neck, electrocardiographic changes and creatine phosphokinase blood levels in patients with diphtheria. (1845655)	Pelupessy J.M.... Daud D.	1991	PIK3C2A
44	Significance of elevated levels of serum creatine phosphokinase in febrile diseases: a prospective study. (2041954)	Cohen O.... Wysenbeek A.J.	1991	PIK3C2A
45	Coupled in vivo activity of creatine phosphokinase and the membrane-bound (Na+,K+)-ATPase in the resting and stimulated electric organ of the electric fish Narcine brasiliensis. (1645345)	Blum H.... Johnson R.G.	1991	PIK3C2A
46	Report of a case of Crohn's disease associated with hyper-creatine phosphokinase-emia. (1803046)	Hayashi K.... Hirata I.	1991	PIK3C2A
47	The evaluation of serum creatine phosphokinase for e stimation of energy expenditure in human subjects (1753445)	Imaki M.... Sei M.	1991	PIK3C2A
48	17 beta hydroxysteroid dehydrogenase and creatine phosphokinase activities and the levels of sex hormones and their receptors in the uterus of patients with fibromyoma or endocrine sterility (2171369)	Arutiunian N.A.... Savchenko O.N.	1990	HSD17B13
49	Statistic correlation of carcinoembryonal antigen (CEA), alpha-feto protein (AFP) and isoenzymes of mitochondrial and BB creatine phosphokinase (CK+-BB and CK-MT) in patients with neoplasms (1697173)	Scarazatti E.... Melloni G.F.	1990	AFP, CKMT1B
50	Evaluation of the activity of creatine phosphokinase for the detection of carriers of Duchenne-type muscular dystrophy in families in the city of Monterrey, Mexico (2236973)	Alvarez Leal M.... Morales Aguilera A.	1990	PIK3C2A

Genes related to creatine phosphokinase according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	CAV3	caveolin 3	11.1
2	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.1	Publications
3	MB	myoglobin	11.1	Publications
4	CHKB	choline kinase beta	11.1	Publications
5	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.1	Publications
6	CKMT1B	creatine kinase, mitochondrial 1B	11.0	Publications
7	ENO3	enolase 3 (beta, muscle)	11.0	Publications
8	CKM	creatine kinase, muscle	11.0	Publications
9	HSD17B13	hydroxysteroid (17-beta) dehydrogenase 13	11.0	Publications
10	GLUL	glutamate-ammonia ligase	11.0	Publications
11	CHKA	choline kinase alpha	11.0	Publications
12	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
13	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
14	AFP	alpha-fetoprotein	11.0	Publications
15	GGT1	gamma-glutamyltransferase 1	11.0	Publications
16	ALPP	alkaline phosphatase, placental	11.0	Publications
17	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
18	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
19	SOD1	superoxide dismutase 1, soluble	11.0	Publications

Pathways related to creatine phosphokinase according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Arginine and proline metabolism20	9.7	CKM, CKMT1B, GLUL
2	Metabolism of amino acids and derivatives38	8.7	GLUL, GPT, CKMT1B, CKM
3	Metabolic pathways20	6.7	PIK3C2A, GGT1, HMGCR, GLUL, ALPP, GPT

Compounds related to creatine phosphokinase according to GeneDecks:

(show top 50)    (show all 176)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.6	CKM
2	phosphocreatine32 18	11.1	CHKA, CKM, PIK3C2A
3	pravastatin32 34 9 18 9	13.7	PIK3C2A, CHKB, CHKA
4	cyclocreatine32	9.7	CKMT1B, CHKA, CHKB
5	succinylcholine32 9 9	11.3	PIK3C2A, CHKB, MB, SLC17A5
6	gemfibrozil32 9 9	11.2	HMGCR, GPT, CHKA, PIK3C2A, CHKB
7	citrate32	9.1	PIK3C2A, GLUL, CHKB, CHKA, MB, SLPI
8	fluvastatin32 34 9 9	12.0	CHKB, GPT, MB, SLPI, HMGCR, PIK3C2A
9	heparin32 9 18 9	11.9	AFP, SLPI, HMGCR, ALPP, CHKB, PIK3C2A
10	glutamate32	8.9	CKM, GLUL, CHKA, GPT, ALPP
11	alpha-hydroxybutyrate32	8.8	MB, PIK3C2A, GPT, CHKB, SLC17A5
12	h2o232	8.8	HMGCR, ALPP, MB, GLUL, SLC17A5
13	lovastatin32 42 9 9	11.7	GGT1, HMGCR, GPT, CHKA, PIK3C2A, CHKB
14	aspartate32	8.7	GLUL, SLC17A5, PIK3C2A, MB, CHKB, GGT1
15	phosphorus32	8.6	GGT1, SLPI, GPT, CHKA, ALPP
16	testosterone32 9 18 9	11.3	CHKB, CHKA, SLPI, MB, ALPP, HSD17B13
17	choline32 9 18 9	11.2	ALPP, CHKB, GGT1, GPT, CHKA, PIK3C2A
18	isoflurane32 9 9	10.2	SLC17A5, ALPP, PIK3C2A, GGT1, GPT
19	prednisolone32 9 9	10.1	MB, ALPP, PIK3C2A, GPT, CHKB, SLC17A5
20	ursodeoxycholic acid32 9 18 9	11.1	GGT1, SLC17A5, HMGCR, GPT, ALPP
21	ascorbic acid32 18	9.1	GLUL, ALPP, CHKB, CHKA, SLPI, SLC17A5
22	ribavirin32 34 9 9	11.1	AFP, SLC17A5, HMGCR, GGT1, GPT
23	sevoflurane32 9 9	10.1	GGT1, SLC17A5, SLPI, ALPP, GPT
24	alpha tocopherol32	8.0	CHKB, CKM, CHKA, MB, GPT, HMGCR
25	atorvastatin32 34 9 18 9	11.9	CHKB, HMGCR, ALPP, GPT, PIK3C2A, CHKA
26	vitamin-e32	7.8	PIK3C2A, SOD1, CHKA, SLC17A5, GGT1, GPT
27	methotrexate32 34 42 9 9	11.8	SLC17A5, GGT1, HMGCR, AFP, GPT, PIK3C2A
28	cocaine32 9 9	9.8	MB, PIK3C2A, GGT1, SLC17A5, ALPP, CHKB
29	vitamin b1232	7.8	SLC17A5, GGT1, ALPP, GPT, MB, AFP
30	norepinephrine32 9 18 9	10.8	SLPI, GLUL, ALPP, MB, CHKB, SLC17A5
31	tamoxifen32 34 9 9	10.7	GGT1, SLC17A5, SLPI, ALPP, CHKB, CHKA
32	bezafibrate32 9 9	9.6	ALPP, GPT, CHKB, PIK3C2A, HMGCR, SLC17A5
33	simvastatin32 34 42 9 18 9	12.5	GPT, ALPP, SLC17A5, HMGCR, AFP, PIK3C2A
34	creatinine32	7.4	CKM, GGT1, AFP, SLPI, HMGCR, GLUL
35	cysteine32	7.3	CHKA, CHKB, CKM, HMGCR, GGT1, SLPI
36	glycogen32 18	8.3	CHKA, SLC17A5, GPT, ENO3, CHKB, CKM
37	ethanol32 34 9 18 9	11.3	GGT1, AFP, SLC17A5, GLUL, GPT, CHKA
38	arginine32	7.2	PIK3C2A, CKM, CHKB, MB, GPT, ALPP
39	urea32 9 18 9	10.2	CHKB, AFP, CHKA, SLC17A5, PIK3C2A, SLPI
40	n acetylcysteine32	7.2	SOD1, HMGCR, CHKA, CHKB, GLUL, MB
41	malondialdehyde32	7.1	GGT1, SLC17A5, SLPI, SOD1, GPT, CHKB
42	oxygen32 18	8.1	CHKA, PIK3C2A, CHKB, GLUL, AFP, SLC17A5
43	uric acid32 18	8.0	GGT1, AFP, SLC17A5, SLPI, SOD1, GPT
44	iron32 18	8.0	GGT1, AFP, SLC17A5, SLPI, SOD1, GLUL
45	thyroxine32 18	7.9	ALPP, GPT, MB, CHKB, CHKA, PIK3C2A
46	serine32	6.5	SLPI, AFP, GGT1, MYH11, MB, CHKA
47	lipid32	6.2	HMGCR, SLC17A5, SOD1, AFP, GGT1, HSD17B13
48	cholesterol32 9 18 9	9.0	GGT1, AFP, SLC17A5, SLPI, HMGCR, GLUL
49	alanine32	5.9	PIK3C2A, CHKB, MB, SOD1, GPT, GLUL
50	lactate32	4.9	AFP, PIK3C2A, GGT1, SLC17A5, SLPI, CKM

Cellular components related to creatine phosphokinase according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	7.4	PIK3C2A, CKM, CHKA, CHKB, ENO3, GPT

Biological processes related to creatine phosphokinase according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	7.6	PIK3C2A, CKM, CHKA, CHKB, ENO3, GPT

Molecular functions related to creatine phosphokinase according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ethanolamine kinase activity	GO:004305	9.9	CHKA, CHKB
2	choline kinase activity	GO:004103	9.6	CHKA, CHKB