Creatine Phosphokinase, Elevated Serum malady

MalaCards: Creatine Phosphokinase, Elevated Serum is related to muscle disorders and compartment syndrome. An important gene associated with Creatine Phosphokinase, Elevated Serum is CAV3 (caveolin 3). The compounds ascorbic acid and thallium have been mentioned in the context of this disorder.

OMIM: 123320

creatine phosphokinase, elevated serum 33 32

Diseases related to creatine phosphokinase, elevated serum by text searches and GeneDecks gene sharing:

(show top 50)    (show all 84)

id	Related Disease	Score	Top Affiliating Genes
1	muscle disorders	12.9	CAV3, CHKB
2	compartment syndrome	12.9	CHKB, MB
3	sudden cardiac death multi-gene panels	12.9	MB, CAV3
4	alpha 1-antitrypsin deficiency	12.9	CHKB, MB
5	centronuclear myopathy	12.9	CHKB, CAV3
6	distal muscular dystrophy	12.9	PIK3C2A, CAV3
7	cerebral aneurysms	12.8	MB, CHKB
8	acute kidney tubular necrosis	12.8	MB, PIK3C2A
9	adult dermatomyositis	12.8	PIK3C2A, CHKB
10	intermediate coronary syndrome	12.8	MB, PIK3C2A
11	ventricular fibrillation	12.8	MB, CHKB
12	ectopic pregnancy	12.8	PIK3C2A, CHKB
13	pericardial effusion	12.8	PIK3C2A, CHKB
14	status asthmaticus	12.8	CHKB, PIK3C2A
15	gas gangrene	12.8	PIK3C2A, CHKB
16	acute mountain sickness	12.8	PIK3C2A, MB
17	hematuria	12.7	PIK3C2A, MB
18	diabetic ketoacidosis	12.7	CHKB, PIK3C2A
19	hypocalcemia	12.7	PIK3C2A, CHKB
20	lactic acidosis	12.7	MB, PIK3C2A
21	hypokalemia	12.7	MB, PIK3C2A
22	limb-girdle muscular dystrophy	12.6	CHKB, CAV3
23	ullrich congenital muscular dystrophy	12.6	PIK3C2A, CHKB
24	idiopathic myopathy	12.6	CHKB, PIK3C2A
25	hemoglobinuria	12.6	MB, PIK3C2A
26	bronchiolitis obliterans	12.6	PIK3C2A, CHKB
27	myostatin-related muscle hypertrophy	12.6	CHKB, CAV3
28	fibromyalgia	12.5	MB, CHKB
29	cramps	12.5	MB, PIK3C2A
30	ppm-x syndrome	12.5	HMGCR, CHKB
31	leptospirosis	12.5	PIK3C2A, MB
32	venous thrombosis	12.5	HMGCR, MB
33	neuromuscular disease	12.5	CHKB, MB, CAV3
34	muscular dystrophy	12.4	CHKB, PIK3C2A, CAV3
35	disseminated intravascular coagulation	12.3	MB, PIK3C2A
36	paine syndrome	12.3	MB, CHKB
37	primary hyperoxaluria	12.3	PIK3C2A, MB
38	neuroleptic malignant syndrome	12.3	PIK3C2A, MB, CHKB
39	cocaine abuse	12.3	CHKB, PIK3C2A, MB
40	malignant hyperthermia	12.3	CHKB, PIK3C2A, MB
41	hypertrophic cardiomyopathy	12.3	CAV3, PIK3C2A, CHKB
42	paralysis	12.3	MB, CHKB, PIK3C2A
43	myocarditis	12.2	MB, CHKB, PIK3C2A
44	oculomotor apraxia cogan type	12.2	CHKB, PIK3C2A, MB
45	acute pancreatitis	12.2	PIK3C2A, MB, CHKB
46	meningitis	12.2	PIK3C2A, MB, CHKB
47	congestive heart failure	12.0	PIK3C2A, CHKB, HMGCR
48	ischemic heart disease	12.0	HMGCR, PIK3C2A, MB
49	eosinophilia	12.0	MB, HMGCR, PIK3C2A
50	syncope	11.9	PIK3C2A, CHKB, CAV3, MB

Clinical features from OMIM: 123320

Approved drugs:

Drug clinical trials:

Genes related to creatine phosphokinase, elevated serum according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CAV3	caveolin 3	11.1
2	CHKB	choline kinase beta	11.1
3	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.1
4	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.1
5	MB	myoglobin	11.1

Compounds related to creatine phosphokinase, elevated serum according to GeneDecks:

(show top 50)    (show all 67)

id	Compound	Score	Top Affiliating Genes
1	ascorbic acid32 18	11.2	CHKB
2	thallium32	9.7	PIK3C2A, CHKB
3	fe3+32	9.7	CHKB, MB
4	ptca32	9.6	PIK3C2A, CHKB
5	coq1032	9.5	CHKB, HMGCR
6	policosanol32	9.4	PIK3C2A, HMGCR
7	clarithromycin32 9 9	11.4	HMGCR, CHKB
8	diclofenac32 34 9 9	12.4	CHKB, MB
9	propofol32 9 9	11.4	PIK3C2A, MB
10	diltiazem32 9 9	11.4	HMGCR, CHKB
11	acetone32	9.4	HMGCR, MB
12	amiodarone32 9 9	11.4	CHKB, HMGCR
13	rosuvastatin32 34 9 9	12.3	CHKB, HMGCR
14	clopidogrel32 34 9 18 9	13.3	CHKB, HMGCR
15	alpha-hydroxybutyrate32	9.3	MB, PIK3C2A, CHKB
16	dantrolene32 9 9	11.3	PIK3C2A, CHKB, MB
17	succinylcholine32 9 9	11.3	PIK3C2A, CHKB, MB
18	gamma-hydroxybutyrate32	9.3	PIK3C2A, CHKB, MB
19	phosphocreatine32 18	10.2	PIK3C2A, MB, CHKB
20	phosphorus32	9.2	PIK3C2A, CHKB
21	halothane32 9 9	11.2	MB, CHKB, PIK3C2A
22	melphalan32 9 9	11.2	MB, CHKB, PIK3C2A
23	prednisolone32 9 9	11.2	CHKB, MB, PIK3C2A
24	cocaine32 9 9	11.2	MB, CHKB, PIK3C2A
25	citrate32	9.2	MB, PIK3C2A, CHKB
26	glycerol32 9 18 9	12.2	CHKB, MB, PIK3C2A
27	theophylline32 9 18 9	12.0	MB, HMGCR, CHKB
28	alpha tocopherol32	9.0	MB, CHKB, HMGCR
29	glycogen32 18	10.0	CAV3, CHKB, PIK3C2A
30	norepinephrine32 9 18 9	12.0	PIK3C2A, CHKB, MB
31	gemfibrozil32 9 9	10.9	CHKB, HMGCR, PIK3C2A
32	cerivastatin32 9 9	10.9	CHKB, PIK3C2A, HMGCR
33	pravastatin32 34 9 18 9	12.9	HMGCR, CHKB, PIK3C2A
34	n acetylcysteine32	8.9	CHKB, MB, HMGCR
35	lovastatin32 42 9 9	11.9	PIK3C2A, CHKB, HMGCR
36	atorvastatin32 34 9 18 9	12.9	PIK3C2A, CHKB, HMGCR
37	simvastatin32 34 42 9 18 9	13.9	PIK3C2A, HMGCR, CHKB
38	methotrexate32 34 42 9 9	12.8	PIK3C2A, HMGCR, CHKB
39	fatty acid32	8.6	PIK3C2A, CHKB, CAV3
40	cyclosporin a32 42	9.5	CHKB, PIK3C2A, HMGCR
41	bezafibrate32 9 9	10.4	PIK3C2A, CHKB, MB, HMGCR
42	fluvastatin32 34 9 9	11.4	PIK3C2A, CHKB, MB, HMGCR
43	thyroxine32 18	9.4	MB, CHKB, HMGCR, PIK3C2A
44	epinephrine32 9 18 9	11.4	PIK3C2A, CHKB, HMGCR, MB
45	cholesterol32 9 18 9	11.4	HMGCR, PIK3C2A, CAV3, CHKB
46	lactate32	8.4	HMGCR, CHKB, PIK3C2A, MB
47	heparin32 9 18 9	11.4	MB, PIK3C2A, CHKB, HMGCR
48	vegf32	8.3	PIK3C2A, HMGCR, CHKB, MB
49	arginine32	8.3	PIK3C2A, HMGCR, MB, CHKB
50	creatinine32	8.0	HMGCR, MB, CHKB, PIK3C2A, CAV3

Biological processes related to creatine phosphokinase, elevated serum according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of MAP kinase activity	GO:043407	9.2	CAV3, HMGCR