MCID: CRS001
MIFTS: 51

Crescentic Glomerulonephritis malady

Summaries for Crescentic Glomerulonephritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a... more...

MalaCards: Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to glomerulonephritis and vasculitis. An important gene associated with Crescentic Glomerulonephritis is MPO (myeloperoxidase), and among its related pathways are Malaria and LDL Oxidation in Atherogenesis. The compounds pge2 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone, and related mouse phenotypes are renal/urinary system and immune system.

Aliases & Classifications for Crescentic Glomerulonephritis

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

crescentic glomerulonephritis 8 10
idiopathic crescentic glomerulonephritis 8 60


External Ids:

Disease Ontology8 DOID:13139
SNOMED-CT56 45406000, 236398000
NCIt39 C35444

Related Diseases for Crescentic Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Crescentic Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.1VCAM1, ACTN4, F2R, IL1R1, SYNPO, PRTN3
2vasculitis31.0VCAM1, PRTN3, MPO, MBL2
3rapidly progressive glomerulonephritis31.0MPO, PRTN3
4iga glomerulonephritis30.9MBL2, SCGB1A1, ITGAL, PRTN3, IL1R1
5endocarditis30.9PRTN3
6arthritis30.8CCL4, CCL3, MPO, PRTN3, IL1R1
7rheumatoid arthritis30.8CCL4, CCL3, MBL2, TNFRSF6B, ITGAL, MPO
8wegener's granulomatosis30.5PRTN3, MPO
9sarcoidosis30.4SCGB1A1, CCL3, CCL4
10proteinuria30.4SCGB1A1, MPO, PRTN3, SYNPO, ACTN4
11multiple myeloma30.3CCL3
12myeloma30.3VCAM1, ITGAL, CCL3, CCL4
13hypertension30.1VCAM1
14malaria30.1DARC
15hepatitis30.1F2R
16pancreatitis30.1MPO
17antiphospholipid syndrome30.1VCAM1
18nephrotic syndrome30.1ACTN4, SYNPO
19adenocarcinoma30.1CTNND1, SCGB1A1, TNFRSF6B
20dermatomyositis30.1VCAM1, CCL3
21hepatitis b30.1ITGAL, MBL2
22pneumonia30.1F2R, MPO, SCGB1A1, MBL2, CCL3
23psoriasis30.1VCAM1, CMA1, IL1R1, ITGAL, CCL4
24systemic lupus erythematosus30.1CCL4, CCL3, MBL2, ITGAL, MPO, PRTN3
25graves' disease30.1ITGAL, MPO, VCAM1
26leukemia30.1CCL4, CCL3, MBL2, SCGB1A1, ITGAL, MPO
27membranous glomerulonephritis10.8
28immune-complex glomerulonephritis10.6
29scleroderma10.5
30diffuse glomerulonephritis10.5
31churg-strauss syndrome10.4
32amyloidosis10.4
33membranoproliferative glomerulonephritis10.3
34proliferative glomerulonephritis10.3
35purpura10.3
36renal cell carcinoma10.3
37bronchiectasis10.2
38polycystic kidney disease10.2
39infective endocarditis10.2
40kidney disease10.2
41leprosy10.2
42panniculitis10.2
43thyroiditis10.2
44tuberculosis10.2
45diabetic nephropathy10.1
46arteriovenous fistula10.1
47plasmodium malariae malaria10.1
48familial mediterranean fever10.1
49granulomatous angiitis10.1
50autoimmune thrombocytopenic purpura10.1

Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to crescentic glomerulonephritis

Clinical Features for Crescentic Glomerulonephritis

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Drugs & Therapeutics for Crescentic Glomerulonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Crescentic Glomerulonephritis

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Anatomical Context for Crescentic Glomerulonephritis

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32MalaCards
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MalaCards organs/tissues related to Crescentic Glomerulonephritis:

32
Kidney, T cells, Bone, Monocytes, Endothelial, Liver, Testes, Thyroid, Bone marrow, Breast, Skin, Lung, Myeloid, Smooth muscle, Lymph node

Animal Models for Crescentic Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9SCGB1A1, CTNND1, SYNPO, IL1R1, ACTN4, MBL2
2MP:00053879.2VCAM1, CCL3, MBL2, SCGB1A1, TFPI, ITGAL
3MP:00053769.0TFPI, SCGB1A1, MBL2, CCL3, C11orf73, ITGAL

Publications for Crescentic Glomerulonephritis

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50PubMed
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Articles related to Crescentic Glomerulonephritis:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Etiology and outcome of crescentic glomerulonephritis. (23024099)
2013
2
An unusual case of Plasmodium vivax malaria monoinfection associated with crescentic glomerulonephritis: a need for vigilance. (22806325)
2013
3
Neutrophil serine proteases promote IL-1I^ generation and injury in necrotizing crescentic glomerulonephritis. (22241891)
2012
4
Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis. (21525855)
2011
5
Severe crescentic glomerulonephritis linked to an acute Hantaan virus infection? (21460361)
2011
6
Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. (21403644)
2011
7
Differential deposition of C4d and MBL in glomeruli of patients with ANCA-negative pauci-immune crescentic glomerulonephritis. (19898926)
2010
8
Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis. (20617355)
2010
9
Pauci-immune crescentic glomerulonephritis associated with ANCA of IgA class. (19084310)
2009
10
Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. (18071760)
2008
11
NKT cells inhibit the development of experimental crescentic glomerulonephritis. (18525002)
2008
12
Inducible co-stimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis. (16540559)
2006
13
Membranous glomerulopathy induced by myeloperoxidase-anti-neutrophil cytoplasmic antibody-related crescentic glomerulonephritis. (16157986)
2005
14
In situ expression of connective tissue growth factor in human crescentic glomerulonephritis. (14758550)
2004
15
Recombinant uteroglobin prevents the experimental crescentic glomerulonephritis. (15327399)
2004
16
Contributions of IL-1beta and IL-1alpha to crescentic glomerulonephritis in mice. (15034093)
2004
17
Fc receptor-mediated accumulation of macrophages in crescentic glomerulonephritis induced by anti-glomerular basement membrane antibody administration in WKY rats. (15096492)
2004
18
Gastric cancer diagnosed in a patient with crescentic glomerulonephritis. (14716523)
2003
19
Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. (12761249)
2003
20
p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis. (12032188)
2002
21
Simultaneous occurrence of diabetic glomerulosclerosis, IgA nephropathy, crescentic glomerulonephritis, and myeloperoxidase-antineutrophil cytoplasmic antibody seropositivity in a Chinese patient. (12324935)
2002
22
Glomerular chemokine expression and the effect of steroid and cyclophosphamide pulse therapy in human crescentic glomerulonephritis. (12411099)
2002
23
Quiz page. IgA nephropathy and superimposed pauci-immune necrotizing crescentic glomerulonephritis, the latter clinically typical of Wegener's granulomatosis. (12460068)
2002
24
Treatment with an antibody to VLA-1 integrin reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis. (12368200)
2002
25
Identification of cellular origin of type I collagen in glomeruli of rats with crescentic glomerulonephritis induced by anti-glomerular basement membrane antibody. (11274263)
2001
26
Crescentic glomerulonephritis is diminished in fibrinogen-deficient mice. (11704568)
2001
27
A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats. (10906168)
2000
28
Osteopontin expression in human crescentic glomerulonephritis. (10620192)
2000
29
Expression of the chemokine monocyte chemoattractant protein-1 and its receptor chemokine receptor 2 in human crescentic glomerulonephritis. (11095646)
2000
30
Therapeutic effects of ulinastatin on experimental crescentic glomerulonephritis in rats. (10754412)
2000
31
Tissue factor pathway inhibitor expression in human crescentic glomerulonephritis. (10200995)
1999
32
Plasma exchange or immunoadsorption in patients with rapidly progressive crescentic glomerulonephritis. A Swedish multi-center study. (10212042)
1999
33
Crescentic glomerulonephritis and centrocytic lymphoma. (10435886)
1999
34
Interleukin-4 ameliorates crescentic glomerulonephritis in Wistar Kyoto rats. (10200996)
1999
35
Cytomegalovirus-induced necrotizing and crescentic glomerulonephritis in a renal transplant patient. (9820453)
1998
36
Reversal of established rat crescentic glomerulonephritis by blockade of macrophage migration inhibitory factor (MIF): potential role of MIF in regulating glucocorticoid production. (10780884)
1998
37
De novo glomerular osteopontin expression in rat crescentic glomerulonephritis. (9453010)
1998
38
Infective endocarditis-induced crescentic glomerulonephritis dramatically improved by plasmapheresis. (9708618)
1998
39
End-stage renal failure due to crescentic glomerulonephritis in a patient with BehAset's syndrome. Review of the literature. (9653837)
1998
40
Prevention of crescentic glomerulonephritis induced by anti-glomerular membrane antibody in tumor necrosis factor-deficient mice. (9881962)
1998
41
Crescentic glomerulonephritis and elevated antimyeloperoxidase antibody in a patient with Churg-Strauss syndrome. (9380224)
1997
42
Antineutrophil cytoplasmic antibodies (ANCA)-associated crescentic glomerulonephritis and propylthiouracil therapy. (8856275)
1996
43
Anti-GBM-associated crescentic glomerulonephritis with discrete IgG deposition, but with no electron-dense material in glomeruli. (8918726)
1996
44
ANCA-associated pauci-immune crescentic glomerulonephritis complicating SjAPgren's syndrome. (8941599)
1996
45
Expression of the multifunctional extracellular matrix protein thrombospondin in crescentic glomerulonephritis. (8778323)
1996
46
Crescentic glomerulonephritis and crystals within glomerular capillaries in an AIDS patient treated with foscarnet. (7618652)
1995
47
Combined treatment in Wegener's granulomatosis with crescentic glomerulonephritis--clinical course and long-term outcome. (8458666)
1993
48
Crescentic glomerulonephritis related to hepatitis B virus. (1495931)
1992
49
Two distinct types of crescentic glomerulonephritis. (1638779)
1992
50
Spontaneous remission in idiopathic membranous glomerulonephritis with crescents. (7063913)
1982

Genetic Variations for Crescentic Glomerulonephritis

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Expression for genes affiliated with Crescentic Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crescentic Glomerulonephritis

Search GEO for disease gene expression data for Crescentic Glomerulonephritis.

Pathways for genes affiliated with Crescentic Glomerulonephritis

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Crescentic Glomerulonephritis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge24410.8ITGAL
2endotoxin4410.7SCGB1A1, VCAM1
3estrogen4410.6MBL2, PRTN3
4cyclophosphamide44 49 1112.6IL1R1, ITGAL, MBL2
5glucose4410.5CCL3, F2R
6dexamethasone44 49 28 1113.5F2R, ITGAL, IL1R1
7zymosan4410.5CCL3, MBL2, MPO
8cuprophan4410.5ITGAL, IL1R1, VCAM1
9peptidoglycan44 2811.4CCL3, CCL4, MBL2, IL1R1
10groalpha4410.4CCL3, VCAM1, CCL4
11cytochalasin b4410.4ITGAL, PRTN3, MPO, CCL4
128-isoprostane4410.4VCAM1, MPO, CCL3
13lipoteichoic acid4410.4MBL2, IL1R1, CCL3
14leukotriene b444 59 2412.4IL1R1, MPO, ITGAL, CCL3
15latex4410.4SCGB1A1, ITGAL, F2R, CCL3, MBL2
16hyaluronic acid44 2411.4SCGB1A1, IL1R1, VCAM1, PRTN3, ITGAL
17diphenyleneiodonium4410.3IL1R1, MPO, VCAM1
18paraffin4410.3MBL2, VCAM1, F2R, IL1R1, CMA1, MPO
19simvastatin44 49 59 28 11 2415.3VCAM1, ITGAL, F2R, CCL4, CCL3
20il 104410.3CCL3, CCL4, IL1R1
21sb 20358044 5911.3CCL3, VCAM1, F2R, IL1R1, CCL4
22fmlp4410.3ITGAL, CCL3, VCAM1, F2R, PRTN3, MPO
23rantes4410.3MBL2, CCL3, CCL4, IL1R1, DARC, ITGAL
24creatinine4410.3MPO, MBL2, SYNPO, SCGB1A1, IL1R1, CCL4
25fibrinogen4410.3ITGAL, VCAM1, IL1R1, F2R, MBL2
26histamine44 28 2412.2MPO, CCL4, CCL3, VCAM1, CTNND1, F2R
27prednisolone44 28 1112.2CCL4, IL1R1, CCL3, MPO, VCAM1, ITGAL
28wortmannin4410.2F2R, VCAM1, CCL3, CCL4, ITGAL
29ionomycin4410.2CCL4, CCL3, ITGAL, PRTN3
30tacrolimus44 49 1112.2CCL3, ITGAL, CCL4, F2R
31superoxide44 2411.2F2R, PRTN3, MPO, ITGAL, CCL4, MBL2
32chloride4410.2F2R, MPO, IL1R1, CCL4
33steroid4410.2CCL3, MBL2, CCL4, IL1R1, SYNPO, SCGB1A1
34n-formylmethionyl-leucylphenylalanine4410.2MPO, ITGAL, PRTN3
35ccl444 2811.2CCL3, CCL4, IL1R1
36pentoxifylline44 1111.1IL1R1, VCAM1, MPO
37oxygen44 2411.1CCL3, MBL2, ITGAL, F2R, PRTN3, SCGB1A1
38phosphatidylinositol4410.1CCL4, VCAM1, ITGAL, TNFRSF6B, F2R, IL1R1
39vegf4410.1CTNND1, MBL2, VCAM1, MPO, CCL3, F2R
40nitric oxide44 11 2412.1IL1R1, MPO, ITGAL, SCGB1A1, VCAM1, CCL4
41cholesterol44 28 11 2413.1CMA1, F2R, IL1R1, ITGAL, CCL3, CCL4
42serine4410.0PRTN3, ACTN4, CCL4, CCL3, CTNND1, TFPI
43heparin44 28 11 2413.0CCL4, CCL3, TFPI, ITGAL, MPO, VCAM1
44cysteine4410.0F2R, IL1R1, ITGAL, MBL2, VCAM1, CMA1
45retinoic acid44 2411.0ITGAL, PRTN3, CCL3, CCL4, F2R, IL1R1
46lipid4410.0MBL2, TFPI, ITGAL, PRTN3, IL1R1, VCAM1
47ccl344 2810.9CCL4, CCL3, IL1R1
48alanine449.8VCAM1, CCL4, CCL3, SCGB1A1, CTNND1, TFPI
49tyrosine449.8VCAM1, IL1R1, DARC, NM, ACTN4, F2R
50calcium44 49 11 2412.6MBL2, CTNND1, CCL3, CCL4, SCGB1A1, ACTN4

GO Terms for genes affiliated with Crescentic Glomerulonephritis

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16Gene Ontology
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Cellular components related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.7CCL3, MBL2, TFPI, IL1R1, F2R, CMA1
2extracellular spaceGO:0056159.4VCAM1, CCL4, CCL3, MBL2, TNFRSF6B, SCGB1A1

Biological processes related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.3MPO, MBL2
2positive regulation of calcium-mediated signalingGO:05085010.2ITGAL, CCL3, CCL4
3positive regulation of calcium ion transportGO:05192810.2F2R, CCL3, CCL4
4positive regulation of natural killer cell chemotaxisGO:200050310.1CCL3, CCL4
5negative regulation by host of viral transcriptionGO:0439229.9CCL3, CCL4
6inflammatory responseGO:0069549.9CCL4, CCL3, ITGAL, DARC, F2R

Molecular functions related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:03172610.2CCL3, CCL4
2CCR5 chemokine receptor bindingGO:0317309.9CCL3, CCL4

Products for genes affiliated with Crescentic Glomerulonephritis

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Sources for Crescentic Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet