MCID: CRS001
MIFTS: 51

Crescentic Glomerulonephritis malady

Summaries for Crescentic Glomerulonephritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a... more...

MalaCards: Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to glomerulonephritis and vasculitis. An important gene associated with Crescentic Glomerulonephritis is MPO (myeloperoxidase), and among its related pathways are Malaria and LDL Oxidation in Atherogenesis. The compounds pge2 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone, and related mouse phenotypes are renal/urinary system and immune system.

Aliases & Classifications for Crescentic Glomerulonephritis

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

crescentic glomerulonephritis 8 10
idiopathic crescentic glomerulonephritis 8 60


External Ids:

Disease Ontology8 DOID:13139
SNOMED-CT56 45406000, 236398000
NCIt39 C35444

Related Diseases for Crescentic Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Crescentic Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.1VCAM1, ACTN4, F2R, IL1R1, SYNPO, PRTN3
2vasculitis31.0VCAM1, PRTN3, MPO, MBL2
3rapidly progressive glomerulonephritis31.0MPO, PRTN3
4iga glomerulonephritis30.9MBL2, SCGB1A1, ITGAL, PRTN3, IL1R1
5endocarditis30.9PRTN3
6arthritis30.8CCL4, CCL3, MPO, PRTN3, IL1R1
7rheumatoid arthritis30.8CCL4, CCL3, MBL2, TNFRSF6B, ITGAL, MPO
8wegener's granulomatosis30.5PRTN3, MPO
9sarcoidosis30.4SCGB1A1, CCL3, CCL4
10proteinuria30.4SCGB1A1, MPO, PRTN3, SYNPO, ACTN4
11multiple myeloma30.3CCL3
12myeloma30.3VCAM1, ITGAL, CCL3, CCL4
13hypertension30.1VCAM1
14malaria30.1DARC
15hepatitis30.1F2R
16pancreatitis30.1MPO
17antiphospholipid syndrome30.1VCAM1
18nephrotic syndrome30.1ACTN4, SYNPO
19adenocarcinoma30.1CTNND1, SCGB1A1, TNFRSF6B
20dermatomyositis30.1VCAM1, CCL3
21hepatitis b30.1ITGAL, MBL2
22pneumonia30.1F2R, MPO, SCGB1A1, MBL2, CCL3
23psoriasis30.1VCAM1, CMA1, IL1R1, ITGAL, CCL4
24systemic lupus erythematosus30.1CCL4, CCL3, MBL2, ITGAL, MPO, PRTN3
25graves' disease30.1ITGAL, MPO, VCAM1
26leukemia30.1CCL4, CCL3, MBL2, SCGB1A1, ITGAL, MPO
27membranous glomerulonephritis10.8
28immune-complex glomerulonephritis10.6
29scleroderma10.5
30diffuse glomerulonephritis10.5
31churg-strauss syndrome10.4
32amyloidosis10.4
33membranoproliferative glomerulonephritis10.3
34proliferative glomerulonephritis10.3
35purpura10.3
36renal cell carcinoma10.3
37bronchiectasis10.2
38polycystic kidney disease10.2
39infective endocarditis10.2
40kidney disease10.2
41leprosy10.2
42panniculitis10.2
43thyroiditis10.2
44tuberculosis10.2
45diabetic nephropathy10.1
46arteriovenous fistula10.1
47plasmodium malariae malaria10.1
48familial mediterranean fever10.1
49granulomatous angiitis10.1
50autoimmune thrombocytopenic purpura10.1

Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to crescentic glomerulonephritis

Clinical Features for Crescentic Glomerulonephritis

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Drugs & Therapeutics for Crescentic Glomerulonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Crescentic Glomerulonephritis

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Anatomical Context for Crescentic Glomerulonephritis

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32MalaCards
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MalaCards organs/tissues related to Crescentic Glomerulonephritis:

32
Kidney, T cells, Bone, Monocytes, Endothelial, Liver, Testes, Thyroid, Bone marrow, Breast, Skin, Lung, Myeloid, Smooth muscle, Lymph node

Animal Models for Crescentic Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9SCGB1A1, CTNND1, SYNPO, IL1R1, ACTN4, MBL2
2MP:00053879.2VCAM1, CCL3, MBL2, SCGB1A1, TFPI, ITGAL
3MP:00053769.0TFPI, SCGB1A1, MBL2, CCL3, C11orf73, ITGAL

Publications for Crescentic Glomerulonephritis

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50PubMed
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Articles related to Crescentic Glomerulonephritis:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in autosomal dominant polycystic kidney disease. (23617397)
2013
2
Acute Kidney Injury due to Crescentic Glomerulonephritis in a Patient with Polycystic Kidney Disease. (23914203)
2013
3
Necrotic crescentic glomerulonephritis and IgA nephropathy: Lee-hass classification revisited. (22382242)
2012
4
Crescentic Glomerulonephritis: an update on Pauci-immune and Anti-GBM diseases. (22313839)
2012
5
Crescentic glomerulonephritis and microangiopathic haemolytic anaemia in a patient with established systemic sclerosis. (21991985)
2011
6
The beneficial effects of statin therapy may not apply to all forms of crescentic glomerulonephritis. (21514453)
2011
7
ANCA-negative Pauci-immune crescentic glomerulonephritis with thrombotic microangiopathy. (21063645)
2010
8
Renal involvement in leprosy: report of progression from diffuse proliferative to crescentic glomerulonephritis. (20016924)
2010
9
Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis with rheumatoid arthritis: a comparison of patients without rheumatoid arthritis. (20339893)
2010
10
A case of infectious endocarditis-associated crescentic glomerulonephritis with intracranial hemorrhage. (20155718)
2010
11
Toll-like receptor 4 stimulation triggers crescentic glomerulonephritis by multiple mechanisms including a direct effect on renal cells. (20566738)
2010
12
Favorable outcome in a case of Mycoplasma pneumoniae-associated crescentic glomerulonephritis. (20336324)
2010
13
Clinical features and renal outcome in lupus patients with diffuse crescentic glomerulonephritis. (19387649)
2009
14
Crescentic glomerulonephritis and circulating antineutrophil cytoplasmic antibodies in scleroderma: a case report and review of the literature. (19473589)
2009
15
Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration. (18245810)
2008
16
Evaluation of the ameliorative effects of immunosuppressants on crescentic glomerulonephritis in SCG/Kj mice. (18602063)
2008
17
Anti-perforin antibody treatment ameliorates experimental crescentic glomerulonephritis in WKY rats. (17622272)
2007
18
Crescentic glomerulonephritis and malignancy--guilty or guilt by association? (16891650)
2006
19
Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice. (16517735)
2006
20
Crescentic glomerulonephritis associated with rifampicin in a patient co-infected with tuberculosis and human immunodeficiency virus. (16629229)
2006
21
Co-existent crescentic glomerulonephritis and renal amyloidosis: a case report and literature review. (16299691)
2005
22
Crescentic glomerulonephritis associated with bacterial endocarditis--antibiotics alone may be sufficient. A case report. (16164165)
2005
23
Acute postinfectious crescentic glomerulonephritis: clinicopathologic presentation and risk factors. (16307349)
2005
24
Successful treatment of crescentic glomerulonephritis associated with adult-onset Henoch-Schoenlein purpura by double-filtration plasmapheresis. (15077873)
2004
25
An unusual endocarditis-induced crescentic glomerulonephritis treated by plasmapheresis. (15630906)
2004
26
Rapidly progressive crescentic glomerulonephritis. (12631105)
2003
27
Connective tissue growth factor participates in scar formation of crescentic glomerulonephritis. (14615415)
2003
28
Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in a patient with a predisposition to autoimmune abnormalities. (24387178)
2003
29
Blocking VLA-4 prevents progression of experimental crescentic glomerulonephritis. (14646362)
2003
30
Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis. (12651599)
2003
31
Immune complex type crescentic glomerulonephritis and ANCA-positivity in a nine-year-old girl. (12026211)
2002
32
Protective effect of a novel and selective inhibitor of inducible nitric oxide synthase on experimental crescentic glomerulonephritis in WKY rats. (12454221)
2002
33
Antiglomerular basement membrane antibody-crescentic glomerulonephritis complicating chronic bronchiectasis. (11411662)
2001
34
B7.1 and B7.2 co-stimulatory molecules regulate crescentic glomerulonephritis. (10820386)
2000
35
Crescentic glomerulonephritis--a manifestation of a nephritogenic Th1 response? (10963141)
2000
36
Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis. (10652028)
2000
37
MIP-1alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis. (10469367)
1999
38
Management of idiopathic crescentic and diffuse proliferative glomerulonephritis: evidence-based recommendations. (10369193)
1999
39
Prevention of crescentic glomerulonephritis in SCG/Kj mice by bone marrow transplantation. (9648940)
1998
40
Crescentic glomerulonephritis developing 3 months after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma. (9818704)
1998
41
Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice. (9211346)
1997
42
D-penicillamine-induced crescentic glomerulonephritis and antimyeloperoxidase antibodies in a patient with scleroderma. Case report and review of the literature. (9426850)
1997
43
A case of necrotizing crescentic glomerulonephritis in which myeloperoxidase antineutrophil cytoplasmic antibodies (ANCA) reflect the disease activity and recognize various neutrophil cytoplasmic constituents]. (9134836)
1997
44
Normocalcaemic hepatorenal sarcoidosis with crescentic glomerulonephritis. (9249790)
1997
45
Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis associated with thiamazole therapy. (8956314)
1996
46
Myeloperoxidase-antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis complicating the course of Graves' disease: report of three adult cases. (7485130)
1995
47
A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. (7836914)
1995
48
A prospective randomized trial of plasma exchange as additive therapy in idiopathic crescentic glomerulonephritis. The Canadian Apheresis Study Group. (1519607)
1992
49
Effect of enalapril on proteinuria and renal function in patients with healed severe crescentic glomerulonephritis. (1798592)
1991
50
Effective radiation therapy for crescentic glomerulonephritis after renal transplantation. (2219362)
1990

Genetic Variations for Crescentic Glomerulonephritis

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Expression for genes affiliated with Crescentic Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crescentic Glomerulonephritis

Search GEO for disease gene expression data for Crescentic Glomerulonephritis.

Pathways for genes affiliated with Crescentic Glomerulonephritis

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Crescentic Glomerulonephritis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge24410.8ITGAL
2endotoxin4410.7VCAM1, SCGB1A1
3estrogen4410.6MBL2, PRTN3
4cyclophosphamide44 49 1112.6MBL2, ITGAL, IL1R1
5glucose4410.5F2R, CCL3
6dexamethasone44 49 28 1113.5F2R, IL1R1, ITGAL
7zymosan4410.5MPO, MBL2, CCL3
8cuprophan4410.5ITGAL, IL1R1, VCAM1
9peptidoglycan44 2811.4IL1R1, MBL2, CCL3, CCL4
10groalpha4410.4CCL4, CCL3, VCAM1
11cytochalasin b4410.4PRTN3, MPO, ITGAL, CCL4
128-isoprostane4410.4VCAM1, MPO, CCL3
13lipoteichoic acid4410.4CCL3, MBL2, IL1R1
14leukotriene b444 59 2412.4IL1R1, MPO, ITGAL, CCL3
15latex4410.4CCL3, MBL2, SCGB1A1, ITGAL, F2R
16hyaluronic acid44 2411.4SCGB1A1, ITGAL, PRTN3, IL1R1, VCAM1
17diphenyleneiodonium4410.3MPO, IL1R1, VCAM1
18paraffin4410.3MBL2, MPO, IL1R1, F2R, CMA1, VCAM1
19simvastatin44 49 59 28 11 2415.3CCL4, CCL3, ITGAL, F2R, VCAM1
20il 104410.3IL1R1, CCL3, CCL4
21sb 20358044 5911.3CCL4, CCL3, IL1R1, F2R, VCAM1
22fmlp4410.3CCL3, ITGAL, MPO, PRTN3, F2R, VCAM1
23rantes4410.3CCL4, CCL3, MBL2, ITGAL, IL1R1, DARC
24creatinine4410.3CCL4, MBL2, SCGB1A1, MPO, SYNPO, IL1R1
25fibrinogen4410.3VCAM1, F2R, IL1R1, ITGAL, MBL2
26histamine44 28 2412.2CCL4, CCL3, CTNND1, MPO, F2R, CMA1
27prednisolone44 28 1112.2CCL4, CCL3, MBL2, ITGAL, MPO, IL1R1
28wortmannin4410.2VCAM1, F2R, ITGAL, CCL3, CCL4
29ionomycin4410.2CCL4, CCL3, ITGAL, PRTN3
30tacrolimus44 49 1112.2CCL4, CCL3, ITGAL, F2R
31superoxide44 2411.2CCL4, MBL2, ITGAL, MPO, PRTN3, F2R
32chloride4410.2F2R, IL1R1, MPO, CCL4
33steroid4410.2CCL4, CCL3, MBL2, SCGB1A1, SYNPO, IL1R1
34n-formylmethionyl-leucylphenylalanine4410.2ITGAL, MPO, PRTN3
35ccl444 2811.2IL1R1, CCL3, CCL4
36oxygen44 2411.1CCL3, MBL2, SCGB1A1, CTNND1, ITGAL, MPO
37phosphatidylinositol4410.1CCL4, TNFRSF6B, SCGB1A1, ITGAL, IL1R1, F2R
38vegf4410.1CCL4, CCL3, MBL2, CTNND1, MPO, IL1R1
39nitric oxide44 11 2412.1CCL4, CCL3, MBL2, SCGB1A1, ITGAL, MPO
40cholesterol44 28 11 2413.1CCL4, CCL3, MBL2, ITGAL, IL1R1, F2R
41ccl344 2811.1CCL4, CCL3, IL1R1
42serine4410.0CCL4, CCL3, CTNND1, TFPI, MPO, PRTN3
43heparin44 28 11 2413.0CCL4, CCL3, TFPI, ITGAL, MPO, IL1R1
44cysteine4410.0CCL4, CCL3, MBL2, ITGAL, IL1R1, F2R
45retinoic acid44 2411.0CCL4, CCL3, ITGAL, MPO, PRTN3, IL1R1
46lipid4410.0MBL2, SCGB1A1, CTNND1, TFPI, ITGAL, PRTN3
47pentoxifylline44 1110.9MPO, IL1R1, VCAM1
48alanine449.8VCAM1, CCL4, CCL3, SCGB1A1, CTNND1, TFPI
49tyrosine449.8CCL4, MBL2, CTNND1, ITGAL, PRTN3, IL1R1
50calcium44 49 11 2412.6CCL4, CCL3, MBL2, SCGB1A1, CTNND1, TFPI

GO Terms for genes affiliated with Crescentic Glomerulonephritis

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16Gene Ontology
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Cellular components related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.7CCL3, MBL2, TFPI, IL1R1, F2R, CMA1
2extracellular spaceGO:0056159.4VCAM1, CCL4, CCL3, MBL2, TNFRSF6B, SCGB1A1

Biological processes related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.3MPO, MBL2
2positive regulation of calcium-mediated signalingGO:05085010.2ITGAL, CCL3, CCL4
3positive regulation of calcium ion transportGO:05192810.2F2R, CCL3, CCL4
4positive regulation of natural killer cell chemotaxisGO:200050310.1CCL3, CCL4
5negative regulation by host of viral transcriptionGO:0439229.9CCL3, CCL4
6inflammatory responseGO:0069549.9CCL4, CCL3, ITGAL, DARC, F2R

Molecular functions related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:03172610.2CCL3, CCL4
2CCR5 chemokine receptor bindingGO:0317309.9CCL3, CCL4

Products for genes affiliated with Crescentic Glomerulonephritis

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Sources for Crescentic Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet