MCID: CRS001
MIFTS: 42

Crescentic Glomerulonephritis malady

Categories: Nephrological diseases

Aliases & Classifications for Crescentic Glomerulonephritis

Aliases & Descriptions for Crescentic Glomerulonephritis:

Name: Crescentic Glomerulonephritis 12 14
Idiopathic Crescentic Glomerulonephritis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13139
NCIt 47 C35444
SNOMED-CT 64 236398000 45406000
UMLS 69 C0403416

Summaries for Crescentic Glomerulonephritis

MalaCards based summary : Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to pauci-immune glomerulonephritis and gastric cancer. An important gene associated with Crescentic Glomerulonephritis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. The drugs Cyclophosphamide and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, kidney and t cells, and related phenotypes are cardiovascular system and immune system

Related Diseases for Crescentic Glomerulonephritis

Diseases related to Crescentic Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
id Related Disease Score Top Affiliating Genes
1 pauci-immune glomerulonephritis 30.2 NPHS2 PTPRO
2 gastric cancer 29.6 NPHS2 PTPRO SYNPO
3 rapidly progressive glomerulonephritis 11.5
4 glomerulonephritis 11.0
5 vasculitis 10.4
6 endocarditis 10.2
7 cutaneous candidiasis 10.2 CCL2 ICAM1
8 dancing eyes-dancing feet syndrome 10.2 CCL2 MPO
9 arthritis 10.2
10 phlegmonous dacryocystitis 10.2 ICAM1 MPO VCAM1
11 dislocation of ear ossicle 10.2 ICAM1 MPO VCAM1
12 retinal ischemia 10.2 CCL2 CCR5 ICAM1
13 rheumatoid arthritis 10.1
14 orofacial granulomatosis 10.1 CCR5 ICAM1 VCAM1
15 epidermolysis bullosa simplex, sutosomal recessive 2 10.1 CCL2 ICAM1 VCAM1
16 hypopyon ulcer 10.1 ICAM1 VCAM1
17 macrodactyly of the foot 10.1 ICAM1 VCAM1
18 hemiplegia 10.1 CCL2 NPHS2 SYNPO
19 subacute glomerulonephritis 10.1 ICAM1 MPO TGFB1
20 neuroaxonal dystrophy 10.1 CCL2 ICAM1 SERPINE1
21 pauci-immune glomerulonephritis with anca 10.1
22 pauci-immune glomerulonephritis without anca 10.1
23 fasciitis 10.1 BPI CTSG MPO
24 microcephaly, progressive, seizures, and cerebral and cerebellar atrophy 10.1 BPI CTSG MPO
25 plantar fasciitis 10.1 CCL2 CCR5 VCAM1
26 ependymoblastoma 10.1 CCR5 ICAM1 MPO VCAM1
27 bare lymphocyte syndrome, type i 10.1 CCL2 ICAM1 MPO VCAM1
28 uveitis 10.1 BPI CCL2 ICAM1 MPO
29 periosteal chondrosarcoma 10.1 ICAM1 SERPINE1 VCAM1
30 perrault syndrome 10.1 ICAM1 SERPINE1 VCAM1
31 membranous nephropathy 10.1
32 craniopharyngioma 10.1 ICAM1 SERPINE1 VCAM1
33 sclerosing adenosis of breast 10.1 CCL2 ICAM1 TGFB1
34 xerophthalmia 10.1 ICAM1 SERPINE1 VCAM1
35 detrusor sphincter dyssynergia 10.0 CCL2 CCR5 TGFB1
36 advanced sleep phase syndrome, familial, 1 10.0 CCL2 CCR5 ICAM1 VCAM1
37 citrullinemia, type ii, neonatal-onset 10.0 ICAM1 SERPINE1 VCAM1
38 churg-strauss syndrome 10.0
39 endotheliitis 10.0
40 major depressive disorder and accelerated response to antidepressant drug treatment 10.0 BPI CCR5 CTSG MPO
41 strawberry gallbladder 10.0 CCL2 ICAM1 MPO TGFB1
42 acute chest syndrome 10.0 CCL2 ICAM1 MPO TGFB1
43 pulmonary valve insufficiency 10.0 CCL2 SERPINE1 TGFB1
44 cervix small cell carcinoma 10.0 ICAM1 SERPINE1 VCAM1
45 biliary cirrhosis, primary, 2 10.0 MPO NPHS2 TGFB1
46 aphthous stomatitis 10.0 NPHS2 TGFB1
47 malignant hyperthermia susceptibility 1 10.0 NPHS2 PTPRO SYNPO
48 lymphoma 10.0
49 amyloidosis 10.0
50 pigmentation disease 10.0 CCL2 ICAM1 TGFB1 VCAM1

Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to Crescentic Glomerulonephritis

Symptoms & Phenotypes for Crescentic Glomerulonephritis

MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 CCR5 ICAM1 MPO NPHS2 PTPRO SERPINE1
2 immune system MP:0005387 9.61 CCL2 CCR5 CTSG ICAM1 MPO SERPINE1
3 neoplasm MP:0002006 9.02 SERPINE1 TGFB1 CCR5 CTSG ICAM1

Drugs & Therapeutics for Crescentic Glomerulonephritis

Drugs for Crescentic Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
5 Immunoglobulin A Phase 2, Phase 3
6 Immunosuppressive Agents Phase 2, Phase 3
7 Protective Agents Phase 2, Phase 3
8 Antiemetics Phase 2, Phase 3
9 Anti-Inflammatory Agents Phase 2, Phase 3
10 Antineoplastic Agents, Hormonal Phase 2, Phase 3
11 Autonomic Agents Phase 2, Phase 3
12 Gastrointestinal Agents Phase 2, Phase 3
13 glucocorticoids Phase 2, Phase 3
14 Hormone Antagonists Phase 2, Phase 3
15 Hormones Phase 2, Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
17 Methylprednisolone acetate Phase 2, Phase 3
18 Methylprednisolone Hemisuccinate Phase 2, Phase 3
19 Neuroprotective Agents Phase 2, Phase 3
20 Peripheral Nervous System Agents Phase 2, Phase 3
21 Prednisolone acetate Phase 2, Phase 3
22 Prednisolone hemisuccinate Phase 2, Phase 3
23 Prednisolone phosphate Phase 2, Phase 3
24
Lisinopril Approved, Investigational Phase 2 83915-83-7 5362119
25 Angiotensin-Converting Enzyme Inhibitors Phase 2
26 Antihypertensive Agents Phase 2
27 HIV Protease Inhibitors Phase 2
28
protease inhibitors Phase 2
29
Mycophenolate mofetil Approved, Investigational 128794-94-5 5281078
30
Mycophenolic acid Approved 24280-93-1 446541
31 Alkylating Agents
32 Anti-Bacterial Agents
33 Antibiotics, Antitubercular
34 Antineoplastic Agents, Alkylating
35 Antirheumatic Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Immunoadsorption in Anti-GBM Glomerulonephritis. Not yet recruiting NCT02765789 Phase 4
2 Trial of Plasma Exchange for Severe Crescentic IgA Nephropathy Enrolling by invitation NCT02647255 Phase 2, Phase 3
3 ACE-inhibitors in Extracapillary Glomerulonephritis Recruiting NCT02682459 Phase 2
4 Mycophenolate Mofetil Versus Intravenous Cyclophosphamide Pulses in the Treatment of Crescentic IgA Nephropathy Completed NCT00301600

Search NIH Clinical Center for Crescentic Glomerulonephritis

Genetic Tests for Crescentic Glomerulonephritis

Anatomical Context for Crescentic Glomerulonephritis

MalaCards organs/tissues related to Crescentic Glomerulonephritis:

39
Neutrophil, Kidney, T Cells, Bone, Monocytes, Endothelial, Bone Marrow

Publications for Crescentic Glomerulonephritis

Articles related to Crescentic Glomerulonephritis:

(show top 50) (show all 558)
id Title Authors Year
1
A rare case of concurrent myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated necrotising and crescentic glomerulonephritis and membranous glomerulonephritis. ( 27931720 )
2017
2
Formation of tight junctions between neighboring podocytes is an early ultrastructural feature in experimental crescentic glomerulonephritis. ( 27920570 )
2016
3
Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy. ( 27293925 )
2016
4
Microscopic polyangiitis with crescentic glomerulonephritis initially presenting as acute pancreatitis. ( 26864299 )
2016
5
Crescentic glomerulonephritis in children: a single centre experience. ( 26684304 )
2016
6
Pauci-Immune Crescentic Glomerulonephritis in Connective Tissue Disease. ( 27504208 )
2016
7
Anti-glomerular basement membrane crescentic glomerulonephritis: A report from India and review of literature. ( 27795626 )
2016
8
Pauci-immune crescentic glomerulonephritis without ANCA in a patient presenting with Candida parapsilosis endocarditis. ( 26897307 )
2016
9
AJKD Atlas of Renal Pathology: Pauci-immune Necrotizing Crescentic Glomerulonephritis. ( 27772637 )
2016
10
Pauci Immune crescentic glomerulonephritis in a patient with T-cell lymphoma and argyria. ( 27189346 )
2016
11
Anti-CD20 therapy and pauci-immune crescentic glomerulonephritis. ( 26786252 )
2016
12
Hilar and para-aortic necrotizing lymphadenopathy associated with antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis. ( 27424701 )
2016
13
Dual anti-neutrophil cytoplasmic antibody-related pauci-immune crescentic glomerulonephritis in a patient with SjAPgren's syndrome. ( 27384449 )
2016
14
Clinical spectrum and outcomes of crescentic glomerulonephritis: A single center experience. ( 27512296 )
2016
15
Poor renal outcomes in patients with anti-neutrophil cytoplasmic antibody-associated crescentic glomerulonephritis and normal renal function at diagnosis. ( 26742758 )
2016
16
Murine Double Minute-2 Inhibition Ameliorates Established Crescentic Glomerulonephritis. ( 27102769 )
2016
17
Crescentic Glomerulonephritis: Variation in Markers of Kidney Function and Structure. ( 26916371 )
2016
18
Necrotizing and crescentic glomerulonephritis with membranous nephropathy in a patient exposed to levamisole-adulterated cocaine. ( 26985374 )
2016
19
Crescentic Glomerulonephritis Associated with Pulmonary Tuberculosis. ( 26894074 )
2016
20
Coexistence of Acute Crescent Glomerulonephritis and IgG4-Related Kidney Disease. ( 27504450 )
2016
21
Glomerular Capillary and Endothelial Cell Injury is Associated with the Formation of Necrotizing and Crescentic Lesions in Crescentic Glomerulonephritis. ( 25797872 )
2015
22
A Case of Membranous Glomerulonephritis with Superimposed Anti-Neutrophil Cytoplasmic Antibody-Associated Rapidly Progressive Crescentic Glomerulonephritis. ( 26306306 )
2015
23
ANCA-Negative Pauci-Immune Crescentic Glomerulonephritis Linked with Non-Small Cell Carcinoma of the Lung. ( 26266249 )
2015
24
Re: prognostic factors in crescentic glomerulonephritis: a single-center experience. ( 26174464 )
2015
25
A rare case of type-I auto-immune hepatitis and thyroiditis presenting with crescentic glomerulonephritis. ( 26354574 )
2015
26
Interleukin 17 signaling drives Type I Interferon induced proliferative crescentic glomerulonephritis in lupus-prone mice. ( 26556529 )
2015
27
Crescentic glomerulonephritis and membranous nephropathy: a rare coexistence. ( 26092054 )
2015
28
Green tea polyphenol (-)-epigallocatechin-3-gallate restores nrf2 activity and ameliorates crescentic glomerulonephritis. ( 25785827 )
2015
29
Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report. ( 26651490 )
2015
30
ANCA-negative crescentic glomerulonephritis closely following two episodes of sepsis. ( 25735581 )
2015
31
Crescentic glomerulonephritis: data from the spanish glomerulonephritis registry. ( 25684569 )
2015
32
Bartonella henselae infection-associated vasculitis and crescentic glomerulonephritis leading to renal allograft loss. ( 25753276 )
2015
33
ANCA positive crescentic glomerulonephritis outcome in a Central East European cohort: a retrospective study. ( 26123651 )
2015
34
Etiology and Outcome of Crescentic Glomerulonephritis FromA aA Single Center in China: A 10-Year Review. ( 26388283 )
2015
35
Pauci-Immune Crescentic Glomerulonephritis: An ANCA-Associated Vasculitis. ( 26688808 )
2015
36
ANCA-positive crescentic glomerulonephritis in a patient with rheumatoid arthritis treated with anti-tumor necrosis factor alpha. ( 26012729 )
2015
37
Hemorrhagic complications associated with PR3-ANCA crescentic glomerulonephritis. ( 25697228 )
2015
38
Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis Associated with Multiple Myeloma. ( 26120578 )
2015
39
Urinary thrombin: a novel marker of glomerular inflammation for the diagnosis of crescentic glomerulonephritis (prospective observational study). ( 25742509 )
2015
40
Prognostic factors in crescentic glomerulonephritis: a single-center experience. ( 25599734 )
2015
41
Infective endocarditis-induced crescentic glomerulonephritis dramatically improved after removal of vegetations and valve replacement. ( 25635440 )
2015
42
Pauci-Immune Necrotizing and Crescentic Glomerulonephritis with Membranous Lupus Nephritis, Fifteen Years after Initial Diagnosis of Secondary Membranous Nephropathy. ( 26558120 )
2015
43
C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases. ( 26586072 )
2015
44
Expression of Ser729 phosphorylated PKCepsilon in experimental crescentic glomerulonephritis: an immunohistochemical study. ( 24998921 )
2014
45
Rapidly progressive crescentic glomerulonephritis: Early treatment is a must. ( 24657897 )
2014
46
IgM nephropathy presenting as full blown crescentic glomerulonephritis: first report in the literature. ( 24849066 )
2014
47
Crescentic glomerulonephritis in a child with Heiner syndrome. ( 26388600 )
2014
48
New-onset bone marrow aplasia in a 15-year-old adolescent with pauci-immune crescentic glomerulonephritis: Questions. ( 24981196 )
2014
49
Susceptibility quantitative trait loci for pathogenic leucocytosis in SCG/Kj mice, a spontaneously occurring crescentic glomerulonephritis and vasculitis model. ( 24654803 )
2014
50
Crescentic glomerulonephritis in non-asthmatic Churg-Strauss syndrome. ( 24626013 )
2014

Variations for Crescentic Glomerulonephritis

Expression for Crescentic Glomerulonephritis

Search GEO for disease gene expression data for Crescentic Glomerulonephritis.

Pathways for Crescentic Glomerulonephritis

Pathways related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 CCL2 CCR5 ICAM1 SERPINE1 TGFB1 VCAM1
2
Show member pathways
12.46 CTSG ICAM1 SERPINE1 TGFB1 VCAM1
3
Show member pathways
12.07 CCL2 ICAM1 MPO SERPINE1
4 11.87 CCL2 ICAM1 VCAM1
5 11.84 CCL2 ICAM1 SERPINE1
6 11.78 CCL2 ICAM1 TGFB1
7 11.73 ICAM1 SERPINE1 VCAM1
8 11.7 CCL2 ICAM1 VCAM1
9 11.68 CCL2 ICAM1 TGFB1 VCAM1
10 11.61 CCL2 ICAM1 TGFB1
11 11.48 ICAM1 TGFB1 VCAM1
12 11.43 NPHS2 PTPRO SYNPO TGFB1
13 11.35 CCL2 ICAM1 SERPINE1 TGFB1 VCAM1
14 11.23 CCL2 CCR5 ICAM1
15 11.15 CCL2 ICAM1 TGFB1 VCAM1
16 10.97 CCL2 ICAM1
17 10.88 TGFB1 VCAM1
18 10.13 CCL2 ICAM1 MPO VCAM1

GO Terms for Crescentic Glomerulonephritis

Cellular components related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 BPI CTSG ICAM1 MPO NPHS2 PTPRO
2 extracellular region GO:0005576 9.95 BPI CCL2 CTSG MPO SERPINE1 TFPI
3 azurophil granule lumen GO:0035578 9.43 BPI CTSG MPO
4 cell surface GO:0009986 9.43 CCR5 CTSG ICAM1 TFPI TGFB1 VCAM1
5 secretory granule GO:0030141 9.33 CTSG MPO TGFB1
6 extracellular space GO:0005615 9.28 BPI CCL2 CTSG ICAM1 MPO SERPINE1
7 plasma membrane GO:0005886 10.02 CCR5 CTSG ICAM1 NPHS2 PTPRO SERPINE1

Biological processes related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.89 BPI CCL2 CCR5 CTSG
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 CCL2 ICAM1 TGFB1
3 response to ethanol GO:0045471 9.71 CCL2 ICAM1 VCAM1
4 cellular response to tumor necrosis factor GO:0071356 9.69 CCL2 ICAM1 VCAM1
5 cellular response to interleukin-1 GO:0071347 9.63 CCL2 ICAM1 TFPI
6 aging GO:0007568 9.62 CCL2 MPO TGFB1 VCAM1
7 defense response to fungus GO:0050832 9.6 CTSG MPO
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 ICAM1 SERPINE1
9 leukocyte cell-cell adhesion GO:0007159 9.58 ICAM1 VCAM1
10 defense response to Gram-negative bacterium GO:0050829 9.58 BPI CTSG SERPINE1
11 positive regulation of collagen biosynthetic process GO:0032967 9.57 CCL2 TGFB1
12 cellular response to interleukin-6 GO:0071354 9.56 CCL2 ICAM1
13 response to hypoxia GO:0001666 9.56 CCL2 ICAM1 TGFB1 VCAM1
14 positive regulation of monocyte chemotaxis GO:0090026 9.55 CCL2 SERPINE1
15 negative regulation of growth of symbiont in host GO:0044130 9.52 CTSG MPO
16 chronic inflammatory response GO:0002544 9.49 CCL2 VCAM1
17 response to cholesterol GO:0070723 9.48 CCR5 TGFB1
18 positive regulation of cellular extravasation GO:0002693 9.43 CCL2 ICAM1
19 response to lipopolysaccharide GO:0032496 9.43 CCL2 CTSG ICAM1 MPO TFPI VCAM1
20 membrane to membrane docking GO:0022614 9.37 ICAM1 VCAM1
21 cellular response to dexamethasone stimulus GO:0071549 9.33 CCL2 ICAM1 TGFB1
22 cellular response to lipopolysaccharide GO:0071222 9.1 CCL2 CCR5 CTSG ICAM1 SERPINE1 TFPI

Molecular functions related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 CCL2 CTSG MPO

Sources for Crescentic Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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