MCID: CRS001
MIFTS: 38

Crescentic Glomerulonephritis malady

Nephrological diseases category

Aliases & Classifications for Crescentic Glomerulonephritis

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Aliases & Descriptions for Crescentic Glomerulonephritis:

Name: Crescentic Glomerulonephritis 10 12
 
Idiopathic Crescentic Glomerulonephritis 10 65


Classifications:



External Ids:

Disease Ontology10 DOID:13139
SNOMED-CT59 45406000, 236398000
NCIt42 C35444

Summaries for Crescentic Glomerulonephritis

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MalaCards based summary: Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to tuberculosis and antiphospholipid syndrome. An important gene associated with Crescentic Glomerulonephritis is MPO (Myeloperoxidase), and among its related pathways are Spinal Cord Injury and Rheumatoid arthritis. Affiliated tissues include neutrophil, bone and kidney, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Related Diseases for Crescentic Glomerulonephritis

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Diseases related to Crescentic Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.6CCL2, ICAM1, TGFB1
2antiphospholipid syndrome30.2CCL2, NPHS2, TGFB1
3systemic lupus erythematosus29.9CCL2, CTSG, ICAM1, VCAM1
4glomerulonephritis11.5
5vasculitis10.8
6endocarditis10.7
7arthritis10.7
8rheumatoid arthritis10.6
9scleroderma10.6
10membranous nephropathy10.5
11churg-strauss syndrome10.5
12endotheliitis10.5
13renal cell carcinoma10.4
14multiple myeloma10.4
15membranoproliferative glomerulonephritis10.4
16membranous glomerulonephritis10.4
17rapidly progressive glomerulonephritis10.4
18amyloidosis10.4
19glomerulosclerosis10.4
20infective endocarditis10.4
21myeloma10.4
22purpura10.4
23thyroiditis10.4
24leprosy10.3
25gastric cancer10.3
26hepatitis10.3
27hemolytic-uremic syndrome10.3
28bronchiectasis10.3
29polycystic kidney disease10.3
30kidney disease10.3
31panniculitis10.3
32polymyositis10.3
33rheumatoid vasculitis10.3
34lymphoma aidsrelated10.2ICAM1, VCAM1
35early-onset non-syndromic cataract10.2LTF, MPO
36inflammatory liposarcoma10.2ICAM1, VCAM1
37hypersensitivity reaction type iv disease10.2ICAM1, MPO
38maxillary sinus inverted papilloma10.2ICAM1, VCAM1
39male reproductive organ benign neoplasm10.2CCL2, ICAM1
40acute pulmonary heart disease10.2CCL2, MPO, SYNPO
41congenital cataract - progressive muscular hypotonia - hearing loss - developmental delay10.2ICAM1, VCAM1
42thrombocytopenia10.2ICAM1, VCAM1
43liver cirrhosis10.2ICAM1, VCAM1
44spinal cord lipoma10.2ICAM1, MPO, VCAM1
45caplan's syndrome10.2ICAM1, MPO, VCAM1
46tinea unguium10.2ICAM1, VCAM1
47polyclonal hypergammaglobulinemia10.2LTF, VCAM1
48renal oncocytoma10.2CCL2, CCR5, ICAM1
49dawson disease10.2CCL2, ICAM1, VCAM1
50malaria10.2

Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to crescentic glomerulonephritis

Symptoms for Crescentic Glomerulonephritis

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Drugs & Therapeutics for Crescentic Glomerulonephritis

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Drugs for Crescentic Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mycophenolate mofetilapproved, investigational864128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate Mofetil
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
2
Cyclophosphamideapproved, investigational252550-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
DB00531
 
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
3
Mycophenolic acidapproved86424280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
Melbex
 
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolic Acid
Mycophenolsaeure
Myfortic
4Immunoglobulin A102

Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial of Plasma Exchange for Severe Crescentic IgA NEphropathyRecruitingNCT02647255Phase 2, Phase 3
2ACE-inhibitors in Extracapillary GlomerulonephritisNot yet recruitingNCT02682459Phase 2
3Mycophenolate Mofetil Versus Intravenous Cyclophosphamide Pulses in the Treatment of Crescentic IgA NephropathyCompletedNCT00301600

Search NIH Clinical Center for Crescentic Glomerulonephritis

Genetic Tests for Crescentic Glomerulonephritis

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Anatomical Context for Crescentic Glomerulonephritis

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MalaCards organs/tissues related to Crescentic Glomerulonephritis:

33
Neutrophil, Bone, Kidney, T cells, Endothelial, Monocytes, Bone marrow

Animal Models for Crescentic Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5CCL2, CCR5, CTSG, LTF, SERPINE1, TGFB1
2MP:00020068.2CCL2, CCR5, CTSG, ICAM1, SERPINE1, TGFB1
3MP:00053977.0CCL2, CCR5, CTSG, ICAM1, LTF, MPO
4MP:00053857.0CCL2, CCR5, ICAM1, MPO, NPHS2, PTPRO
5MP:00107686.9CCL2, CCR5, CTSG, ICAM1, MPO, NPHS2
6MP:00053766.8CCL2, CCR5, ICAM1, LTF, MPO, NPHS2
7MP:00053876.7CCL2, CCR5, CTSG, ICAM1, LTF, MPO

Publications for Crescentic Glomerulonephritis

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Articles related to Crescentic Glomerulonephritis:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Re: prognostic factors in crescentic glomerulonephritis: a single-center experience. (26174464)
2015
2
Interleukin 17 signaling drives Type I Interferon induced proliferative crescentic glomerulonephritis in lupus-prone mice. (26556529)
2015
3
Clinicopathologic spectrum of crescentic glomerulonephritis: a hospital-based study. (24821180)
2014
4
Necrotizing crescentic glomerulonephritis in a patient with positive serologies for lupus and antineutrophil cytoplasmic antibodies. (25259824)
2014
5
ANCA-mediated crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane. (24821165)
2014
6
Update on crescentic glomerulonephritis. (24948005)
2014
7
Management of crescentic glomerulonephritis: what are the recent advances? (23689584)
2013
8
Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in autosomal dominant polycystic kidney disease. (23617397)
2013
9
Characteristics and outcome of crescentic glomerulonephritis in patients with both antineutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody. (23624587)
2013
10
Mice with defective Fas ligand are protected from crescentic glomerulonephritis. (21918502)
2012
11
Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis. (19796023)
2009
12
Anti-VEGF therapy for crescentic glomerulonephritis? (18371550)
2008
13
Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. (18071760)
2008
14
Periglomerular accumulation of dendritic cells in rat crescentic glomerulonephritis. (17557270)
2007
15
Antineutrophil cytoplasmic autoantibody-negative Pauci-immune crescentic glomerulonephritis. (17215440)
2007
16
T cells in crescentic glomerulonephritis. (16624930)
2006
17
Crescentic glomerulonephritis in a child with infective endocarditis. (16703379)
2006
18
A rare form of crescentic glomerulonephritis with mixed immunopathological features. (15841695)
2004
19
Thrombotic thrombocytopenic purpura complicating SjAPgren's syndrome with crescentic glomerulonephritis and membranous nephritis. (17143670)
2004
20
In situ expression of connective tissue growth factor in human crescentic glomerulonephritis. (14758550)
2004
21
Rapidly progressive crescentic glomerulonephritis. (12631105)
2003
22
Pauci-immune crescentic glomerulonephritis. (15025274)
2003
23
Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis. (14633134)
2003
24
p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis. (12032188)
2002
25
Preventive effect of sulphated colominic acid on P-selectin-dependent infiltration of macrophages in experimentally induced crescentic glomerulonephritis. (12100021)
2002
26
Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis. (11168935)
2001
27
Coexistence of Fabry's disease and necrotizing and crescentic glomerulonephritis. (11200872)
2001
28
Early renal allograft loss in a patient with crescentic glomerulonephritis in the native kidney. (11136188)
2001
29
Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis. (10878552)
2000
30
B7.1 and B7.2 co-stimulatory molecules regulate crescentic glomerulonephritis. (10820386)
2000
31
Crescentic glomerulonephritis--a manifestation of a nephritogenic Th1 response? (10963141)
2000
32
Tissue factor, plasminogen activator inhibitor-1, and thrombin receptor expression in human crescentic glomerulonephritis. (10739796)
2000
33
Immunopathogenesis of crescentic glomerulonephritis. (10456257)
1999
34
Necrotizing-crescentic glomerulonephritis in ANCA-associated vasculitis: the role of monocytes. (10435868)
1999
35
Therapeutic effect of glucocorticoid on experimental crescentic glomerulonephritis. (10521089)
1999
36
Expression of lymphotactin mRNA in experimental crescentic glomerulonephritis. (9717977)
1998
37
Cytomegalovirus-induced necrotizing and crescentic glomerulonephritis in a renal transplant patient. (9820453)
1998
38
Quantification of changes in transforming growth factor-beta1 gene expression in experimental crescentic glomerulonephritis. (9034137)
1997
39
Tissue factor in crescentic glomerulonephritis. (9060816)
1997
40
Crucial role of CD8-positive lymphocytes in glomerular expression of ICAM-1 and cytokines in crescentic glomerulonephritis of WKY rats. (9144517)
1997
41
Modulators of crescentic glomerulonephritis. (8959617)
1996
42
Long-term clinical course in acute crescentic glomerulonephritis. (8899486)
1996
43
Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis associated with thiamazole therapy. (8956314)
1996
44
Renal expression of tissue factor pathway inhibitor and evidence for a role in crescentic glomerulonephritis in rabbits. (8755641)
1996
45
Myeloperoxidase-antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis complicating the course of Graves' disease: report of three adult cases. (7485130)
1995
46
Is the association between crescentic glomerulonephritis and renal cell carcinoma coincidental? (8302427)
1993
47
Methylprednisolone and cyclophosphamide pulse therapy in crescentic glomerulonephritis: safety and effectiveness. (8210561)
1993
48
Crescentic glomerulonephritis related to hepatitis B virus. (1495931)
1992
49
Crescentic glomerulonephritis in children: a review of 43 cases. (1415376)
1992
50
Correlation between T cells and experimental crescentic glomerulonephritis. (2125253)
1990

Variations for Crescentic Glomerulonephritis

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Expression for genes affiliated with Crescentic Glomerulonephritis

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Search GEO for disease gene expression data for Crescentic Glomerulonephritis.

Pathways for genes affiliated with Crescentic Glomerulonephritis

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GO Terms for genes affiliated with Crescentic Glomerulonephritis

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Cellular components related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.5CTSG, LTF, MPO, TGFB1
2cell surfaceGO:00099868.0CCR5, CTSG, ICAM1, LTF, TGFB1, VCAM1
3extracellular exosomeGO:00700626.3BPI, CTSG, ICAM1, LTF, MPO, NPHS2
4extracellular spaceGO:00056156.2BPI, CCL2, CTSG, ICAM1, LTF, MPO

Biological processes related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cellular extravasationGO:000269310.5CCL2, ICAM1
2positive regulation of collagen biosynthetic processGO:003296710.4CCL2, TGFB1
3negative regulation of growth of symbiont in hostGO:004413010.3CTSG, MPO
4lipopolysaccharide-mediated signaling pathwayGO:003166310.3CCL2, TGFB1
5negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.2ICAM1, SERPINE1
6negative regulation of endothelial cell apoptotic processGO:200035210.2ICAM1, SERPINE1
7response to cholesterolGO:007072310.2CCR5, TGFB1
8membrane to membrane dockingGO:002261410.1ICAM1, VCAM1
9defense response to fungusGO:005083210.1CTSG, MPO
10positive regulation of monocyte chemotaxisGO:009002610.1CCL2, SERPINE1
11leukocyte cell-cell adhesionGO:000715910.0ICAM1, VCAM1
12cellular response to dexamethasone stimulusGO:00715499.9CCL2, TGFB1
13positive regulation of NF-kappaB transcription factor activityGO:00510929.8ICAM1, LTF, TGFB1
14response to hypoxiaGO:00016669.6CCL2, ICAM1, TGFB1
15cellular response to lipopolysaccharideGO:00712229.4CCL2, CCR5, ICAM1, SERPINE1
16transforming growth factor beta receptor signaling pathwayGO:00071799.2CCL2, SERPINE1, TGFB1
17immune responseGO:00069559.0BPI, CCL2, CCR5, CTSG
18extracellular matrix organizationGO:00301988.2CTSG, ICAM1, SERPINE1, TGFB1, VCAM1

Molecular functions related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.3CCL2, CTSG, LTF, MPO

Sources for Crescentic Glomerulonephritis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet