MCID: CRS001
MIFTS: 44

Crescentic Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Crescentic Glomerulonephritis

MalaCards integrated aliases for Crescentic Glomerulonephritis:

Name: Crescentic Glomerulonephritis 12 14
Idiopathic Crescentic Glomerulonephritis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13139
NCIt 46 C35444
SNOMED-CT 64 236398000 45406000
UMLS 69 C0403416

Summaries for Crescentic Glomerulonephritis

MalaCards based summary : Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to rapidly progressive glomerulonephritis and glomerulonephritis. An important gene associated with Crescentic Glomerulonephritis is MPO (Myeloperoxidase), and among its related pathways/superpathways are Degradation of the extracellular matrix and Selenium Micronutrient Network. The drugs Cyclophosphamide and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, kidney and t cells, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and cardiovascular system

Related Diseases for Crescentic Glomerulonephritis

Diseases related to Crescentic Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 rapidly progressive glomerulonephritis 33.0 ICAM1 MPO
2 glomerulonephritis 31.3 CCL2 ICAM1 MPO NPHS2 VCAM1
3 rheumatoid vasculitis 30.3 ICAM1 VCAM1
4 bronchiectasis 30.0 BPI CTSG MPO
5 henoch-schoenlein purpura 30.0 ICAM1 MPO VCAM1
6 vasculitis 29.9 BPI CCL2 CTSG ICAM1 MPO VCAM1
7 wegener granulomatosis 29.6 BPI CCR5 CTSG MPO
8 focal segmental glomerulosclerosis 1 29.2 NPHS2 PTPRO WT1
9 systemic lupus erythematosus 29.1 CCL2 CCR5 CTSG ICAM1 MPO VCAM1
10 nephrotic syndrome 28.9 NPHS2 PTPRO SYNPO WT1
11 focal segmental glomerulosclerosis 28.9 NPHS2 PTPRO SYNPO WT1
12 herpes simplex virus keratitis 10.4 CCL2 ICAM1
13 lymphocytic vasculitis 10.4 ICAM1 VCAM1
14 cortical thymoma 10.4 ICAM1 VCAM1
15 mooren's ulcer 10.3 ICAM1 VCAM1
16 endocarditis 10.3
17 actinic prurigo 10.3 ICAM1 VCAM1
18 hypersensitivity reaction type iii disease 10.3 ICAM1 MPO
19 pleurisy 10.3 CCL2 ICAM1 MPO
20 pulmonary sarcoidosis 10.3 CCL2 CCR5 ICAM1
21 mesangial proliferative glomerulonephritis 10.3 CCL2 CCR5
22 limbal stem cell deficiency 10.3 ICAM1 VCAM1
23 membranous nephropathy 10.3
24 arthritis 10.3
25 respiratory system disease 10.3 CCL2 ICAM1 MPO
26 leukostasis 10.2 ICAM1 MPO VCAM1
27 rheumatoid arthritis 10.2
28 microvascular complications of diabetes 1 10.2 CCL2 ICAM1 VCAM1
29 pauci-immune glomerulonephritis 10.2
30 pauci-immune glomerulonephritis without anca 10.2
31 pauci-immune glomerulonephritis with anca 10.2
32 oral lichen planus 10.2 CCR5 ICAM1 VCAM1
33 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
34 trypanosomiasis 10.2 CCL2 ICAM1 VCAM1
35 nephrotic syndrome, type 2 10.2 NPHS2 SERPINE1
36 allergic rhinitis 10.1 ICAM1 MPO VCAM1
37 lipoid nephrosis 10.1 CCL2 NPHS2 SYNPO
38 nephrosclerosis 10.1 CCL2 NPHS2 SYNPO
39 sclerosing cholangitis 10.1 BPI CTSG MPO
40 post-thrombotic syndrome 10.1 CCL2 ICAM1 SERPINE1
41 arteriosclerosis obliterans 10.1 ICAM1 VCAM1
42 churg-strauss syndrome 10.1
43 endotheliitis 10.1
44 lung disease 10.1 CCL2 CTSG MPO
45 cholangitis, primary sclerosing 10.1 BPI CTSG MPO
46 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 10.1 NPHS2 PTPRO
47 familial nephrotic syndrome 10.1 NPHS2 WT1
48 urinary system disease 10.1 CCL2 NPHS2 SYNPO
49 idiopathic interstitial pneumonia 10.1 CCL2 ICAM1 SERPINE1
50 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 CCL2 ICAM1 MPO VCAM1

Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to Crescentic Glomerulonephritis

Symptoms & Phenotypes for Crescentic Glomerulonephritis

GenomeRNAi Phenotypes related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Resistant to vaccinia virus (VACV-A4L) infection GR00351-A-1 9.1 CCR5 ICAM1 MPO PTPRO SERPINE1 WT1

MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 ICAM1 MPO NPHS2 PTPRO SERPINE1 TFPI
2 immune system MP:0005387 9.61 ICAM1 MPO SERPINE1 TFPI VCAM1 WT1
3 neoplasm MP:0002006 9.02 ICAM1 SERPINE1 WT1 CCR5 CTSG

Drugs & Therapeutics for Crescentic Glomerulonephritis

Drugs for Crescentic Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
5 Immunosuppressive Agents Phase 2, Phase 3
6 Protective Agents Phase 2, Phase 3
7 Antiemetics Phase 2, Phase 3
8 Anti-Inflammatory Agents Phase 2, Phase 3
9 Antineoplastic Agents, Hormonal Phase 2, Phase 3
10 Autonomic Agents Phase 2, Phase 3
11 Gastrointestinal Agents Phase 2, Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Hormone Antagonists Phase 2, Phase 3
14 Hormones Phase 2, Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
16 Immunoglobulin A Phase 2, Phase 3
17 Methylprednisolone acetate Phase 2, Phase 3
18 Methylprednisolone Hemisuccinate Phase 2, Phase 3
19 Neuroprotective Agents Phase 2, Phase 3
20 Peripheral Nervous System Agents Phase 2, Phase 3
21 Prednisolone acetate Phase 2, Phase 3
22 Prednisolone hemisuccinate Phase 2, Phase 3
23 Prednisolone phosphate Phase 2, Phase 3
24
Lisinopril Approved, Investigational Phase 2 83915-83-7, 76547-98-3 5362119
25 Angiotensin-Converting Enzyme Inhibitors Phase 2
26 Antihypertensive Agents Phase 2
27 HIV Protease Inhibitors Phase 2
28
protease inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoadsorption in Anti-GBM Glomerulonephritis. Not yet recruiting NCT02765789 Phase 4
2 Trial of Plasma Exchange for Severe Crescentic IgA Nephropathy Enrolling by invitation NCT02647255 Phase 2, Phase 3 Methylprednisolone pulse
3 ACE-inhibitors in Extracapillary Glomerulonephritis Recruiting NCT02682459 Phase 2 Lisinopril

Search NIH Clinical Center for Crescentic Glomerulonephritis

Genetic Tests for Crescentic Glomerulonephritis

Anatomical Context for Crescentic Glomerulonephritis

MalaCards organs/tissues related to Crescentic Glomerulonephritis:

38
Neutrophil, Kidney, T Cells, Bone, Endothelial, Monocytes, Bone Marrow

Publications for Crescentic Glomerulonephritis

Articles related to Crescentic Glomerulonephritis:

(show top 50) (show all 580)
# Title Authors Year
1
Levamisole Induced Pauci Immune Focal Necrotizing and Crescentic Glomerulonephritis. ( 29292489 )
2018
2
Tuberculosis and pauci-immune crescentic glomerulonephritis. ( 29437730 )
2018
3
18F-FDG PET/CT Imaging of Necrotizing Crescentic Glomerulonephritis With Anti-Glomerular Basement Membrane Disease. ( 29293138 )
2018
4
Hypocomplementemic Urticarial Vasculitis Syndrome With Crescentic Glomerulonephritis. ( 29406049 )
2018
5
Fibrillary glomerulonephritis presenting as crescentic glomerulonephritis. ( 28356674 )
2017
6
Primary SjAPgren's syndrome complicated by anti-neutrophil cytoplasmic antibody-mediated crescentic glomerulonephritis. ( 28937084 )
2017
7
MPO-C-ANCA-associated necrotising and crescentic glomerulonephritis. ( 28491331 )
2017
8
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus. ( 29319773 )
2017
9
The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association with Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation. ( 28326083 )
2017
10
Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. ( 29184126 )
2017
11
Glomerular disease: Crescentic glomerulonephritis: beyond the immune system. ( 28298632 )
2017
12
Complement activation in pauci-immune necrotizing and crescentic glomerulonephritis: results of a proteomic analysis. ( 28391334 )
2017
13
MMP2 and MMP9 associate with crescentic glomerulonephritis. ( 28584626 )
2017
14
CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis. ( 29276101 )
2017
15
The Regulatory T-cell Transcription Factor Foxp3 Protects against Crescentic Glomerulonephritis. ( 28469165 )
2017
16
Crescentic Glomerulonephritis With Immunoglobulin G4-Related Disease. ( 28918828 )
2017
17
ANCA-positive IgA nephropathy without necrotising or crescentic glomerulonephritis: a clinical conundrum. ( 29170179 )
2017
18
Clinicopathological Characteristics and Outcomes of Diffuse Crescentic Glomerulonephritis - A Single Center Experience from Southern India. ( 29207754 )
2017
19
Concurrent IgG4-related tubulointerstitial nephritis and IgG4 myeloperoxidase-anti-neutrophil cytoplasmic antibody positive crescentic glomerulonephritis: A case report. ( 28514287 )
2017
20
A rare case of concurrent myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated necrotising and crescentic glomerulonephritis and membranous glomerulonephritis. ( 27931720 )
2017
21
Medullary angiitis and pauci-immune crescentic glomerulonephritis. ( 28670084 )
2017
22
Murine Double Minute-2 Inhibition Ameliorates Established Crescentic Glomerulonephritis. ( 27102769 )
2016
23
Poor renal outcomes in patients with anti-neutrophil cytoplasmic antibody-associated crescentic glomerulonephritis and normal renal function at diagnosis. ( 26742758 )
2016
24
Pauci-immune crescentic glomerulonephritis associated with use of trimethoprim-sulfamethoxazole. ( 28508974 )
2016
25
Hilar and para-aortic necrotizing lymphadenopathy associated with antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis. ( 27424701 )
2016
26
AJKD Atlas of Renal Pathology: Pauci-immune Necrotizing Crescentic Glomerulonephritis. ( 27772637 )
2016
27
Anti-CD20 therapy and pauci-immune crescentic glomerulonephritis. ( 26786252 )
2016
28
Clinical spectrum and outcomes of crescentic glomerulonephritis: A single center experience. ( 27512296 )
2016
29
Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy. ( 27293925 )
2016
30
Pauci Immune crescentic glomerulonephritis in a patient with T-cell lymphoma and argyria. ( 27189346 )
2016
31
Pauci-Immune Crescentic Glomerulonephritis in Connective Tissue Disease. ( 27504208 )
2016
32
Crescentic glomerulonephritis in children: a single centre experience. ( 26684304 )
2016
33
Necrotizing and crescentic glomerulonephritis with membranous nephropathy in a patient exposed to levamisole-adulterated cocaine. ( 26985374 )
2016
34
Anti-glomerular basement membrane crescentic glomerulonephritis: A report from India and review of literature. ( 27795626 )
2016
35
Microscopic polyangiitis with crescentic glomerulonephritis initially presenting as acute pancreatitis. ( 26864299 )
2016
36
Crescentic Glomerulonephritis: Variation in Markers of Kidney Function and Structure. ( 26916371 )
2016
37
Crescentic Glomerulonephritis Associated with Pulmonary Tuberculosis. ( 26894074 )
2016
38
Extreme Thrombocytosis Presenting in Anti-Neutrophil Cytoplasmic Autoantibodies-Associated Crescentic Glomerulonephritis with Immune Complex Deposits: A Case Report. ( 28180010 )
2016
39
Pauci-immune crescentic glomerulonephritis without ANCA in a patient presenting with Candida parapsilosis endocarditis. ( 26897307 )
2016
40
Coexistence of Acute Crescent Glomerulonephritis and IgG4-Related Kidney Disease. ( 27504450 )
2016
41
Formation of tight junctions between neighboring podocytes is an early ultrastructural feature in experimental crescentic glomerulonephritis. ( 27920570 )
2016
42
Dual anti-neutrophil cytoplasmic antibody-related pauci-immune crescentic glomerulonephritis in a patient with SjAPgren's syndrome. ( 27384449 )
2016
43
Glomerular Capillary and Endothelial Cell Injury is Associated with the Formation of Necrotizing and Crescentic Lesions in Crescentic Glomerulonephritis. ( 25797872 )
2015
44
ANCA-positive crescentic glomerulonephritis in a patient with rheumatoid arthritis treated with anti-tumor necrosis factor alpha. ( 26012729 )
2015
45
Crescentic glomerulonephritis and membranous nephropathy: a rare coexistence. ( 26092054 )
2015
46
Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report. ( 26651490 )
2015
47
Infective endocarditis-induced crescentic glomerulonephritis dramatically improved after removal of vegetations and valve replacement. ( 25635440 )
2015
48
A Case of Membranous Glomerulonephritis with Superimposed Anti-Neutrophil Cytoplasmic Antibody-Associated Rapidly Progressive Crescentic Glomerulonephritis. ( 26306306 )
2015
49
Interleukin 17 signaling drives Type I Interferon induced proliferative crescentic glomerulonephritis in lupus-prone mice. ( 26556529 )
2015
50
Re: prognostic factors in crescentic glomerulonephritis: a single-center experience. ( 26174464 )
2015

Variations for Crescentic Glomerulonephritis

Expression for Crescentic Glomerulonephritis

Search GEO for disease gene expression data for Crescentic Glomerulonephritis.

Pathways for Crescentic Glomerulonephritis

GO Terms for Crescentic Glomerulonephritis

Cellular components related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 BPI CTSG ICAM1 MPO NPHS2 PTPRO
2 cell surface GO:0009986 9.35 CCR5 CTSG ICAM1 TFPI VCAM1
3 azurophil granule lumen GO:0035578 9.33 BPI CTSG MPO
4 extracellular space GO:0005615 9.23 BPI CCL2 CTSG ICAM1 MPO SERPINE1

Biological processes related to Crescentic Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.81 BPI CCL2 CCR5 CTSG
2 cellular response to tumor necrosis factor GO:0071356 9.65 CCL2 ICAM1 VCAM1
3 defense response to Gram-negative bacterium GO:0050829 9.58 BPI CTSG SERPINE1
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 ICAM1 SERPINE1
5 defense response to fungus GO:0050832 9.52 CTSG MPO
6 cellular response to interleukin-1 GO:0071347 9.5 CCL2 ICAM1 TFPI
7 leukocyte cell-cell adhesion GO:0007159 9.49 ICAM1 VCAM1
8 negative regulation of blood coagulation GO:0030195 9.46 SERPINE1 TFPI
9 negative regulation of growth of symbiont in host GO:0044130 9.43 CTSG MPO
10 glomerulus development GO:0032835 9.37 PTPRO WT1
11 response to lipopolysaccharide GO:0032496 9.35 CTSG ICAM1 MPO TFPI VCAM1
12 glomerular visceral epithelial cell differentiation GO:0072112 9.26 PTPRO WT1
13 membrane to membrane docking GO:0022614 9.16 ICAM1 VCAM1
14 cellular response to lipopolysaccharide GO:0071222 9.1 CCL2 CCR5 CTSG ICAM1 SERPINE1 TFPI

Sources for Crescentic Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....