MCID: CRS001
MIFTS: 43

Crescentic Glomerulonephritis malady

Nephrological diseases category

Summaries for Crescentic Glomerulonephritis

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a... more...

MalaCards: Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to glomerulonephritis and nephritis. An important gene associated with Crescentic Glomerulonephritis is TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy). The compounds chloramphenicol and heparin have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and monocytes, and related mouse phenotype immune system.

Aliases & Classifications for Crescentic Glomerulonephritis

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

crescentic glomerulonephritis 9 11
idiopathic crescentic glomerulonephritis 9 63


External Ids:

Disease Ontology9 DOID:13139
SNOMED-CT59 45406000, 236398000
NCIt41 C35444

Related Diseases for Crescentic Glomerulonephritis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to crescentic glomerulonephritis

Symptoms for Crescentic Glomerulonephritis

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Drugs & Therapeutics for Crescentic Glomerulonephritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Crescentic Glomerulonephritis

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Anatomical Context for Crescentic Glomerulonephritis

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34MalaCards
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MalaCards organs/tissues related to Crescentic Glomerulonephritis:

34
Kidney, T cells, Monocytes, Endothelial, Bone, Testes, Thyroid, Liver, Bone marrow, Breast, Skin, Lung, Lymph node

Animal Models for Crescentic Glomerulonephritis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6CMA1, MPO, SCGB1A1, TFPI, DARC

Publications for Crescentic Glomerulonephritis

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53PubMed
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Articles related to Crescentic Glomerulonephritis:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Management of crescentic glomerulonephritis: what are the recent advances? (23689584)
2013
2
Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in autosomal dominant polycystic kidney disease. (23617397)
2013
3
Characteristics and outcome of crescentic glomerulonephritis in patients with both antineutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody. (23624587)
2013
4
Mice with defective Fas ligand are protected from crescentic glomerulonephritis. (21918502)
2012
5
Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis. (19796023)
2009
6
Anti-VEGF therapy for crescentic glomerulonephritis? (18371550)
2008
7
Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. (18071760)
2008
8
Periglomerular accumulation of dendritic cells in rat crescentic glomerulonephritis. (17557270)
2007
9
Antineutrophil cytoplasmic autoantibody-negative Pauci-immune crescentic glomerulonephritis. (17215440)
2007
10
T cells in crescentic glomerulonephritis. (16624930)
2006
11
Crescentic glomerulonephritis in a child with infective endocarditis. (16703379)
2006
12
A rare form of crescentic glomerulonephritis with mixed immunopathological features. (15841695)
2004
13
Thrombotic thrombocytopenic purpura complicating SjAPgren's syndrome with crescentic glomerulonephritis and membranous nephritis. (17143670)
2004
14
In situ expression of connective tissue growth factor in human crescentic glomerulonephritis. (14758550)
2004
15
Rapidly progressive crescentic glomerulonephritis. (12631105)
2003
16
Pauci-immune crescentic glomerulonephritis. (15025274)
2003
17
Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis. (14633134)
2003
18
Gastric cancer diagnosed in a patient with crescentic glomerulonephritis. (14716523)
2003
19
p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis. (12032188)
2002
20
Preventive effect of sulphated colominic acid on P-selectin-dependent infiltration of macrophages in experimentally induced crescentic glomerulonephritis. (12100021)
2002
21
Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis. (11168935)
2001
22
Coexistence of Fabry's disease and necrotizing and crescentic glomerulonephritis. (11200872)
2001
23
Early renal allograft loss in a patient with crescentic glomerulonephritis in the native kidney. (11136188)
2001
24
Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis. (10878552)
2000
25
B7.1 and B7.2 co-stimulatory molecules regulate crescentic glomerulonephritis. (10820386)
2000
26
Crescentic glomerulonephritis--a manifestation of a nephritogenic Th1 response? (10963141)
2000
27
Tissue factor, plasminogen activator inhibitor-1, and thrombin receptor expression in human crescentic glomerulonephritis. (10739796)
2000
28
Immunopathogenesis of crescentic glomerulonephritis. (10456257)
1999
29
Necrotizing-crescentic glomerulonephritis in ANCA-associated vasculitis: the role of monocytes. (10435868)
1999
30
Therapeutic effect of glucocorticoid on experimental crescentic glomerulonephritis. (10521089)
1999
31
First report of tropical myositis and crescentic glomerulonephritis in a renal transplant recipient. (10585331)
1999
32
A clinical and pathological study on the characteristics and factors influencing the prognosis of crescentic glomerulonephritis using a cluster analysis. (10504549)
1999
33
Expression of lymphotactin mRNA in experimental crescentic glomerulonephritis. (9717977)
1998
34
Cytomegalovirus-induced necrotizing and crescentic glomerulonephritis in a renal transplant patient. (9820453)
1998
35
Quantification of changes in transforming growth factor-beta1 gene expression in experimental crescentic glomerulonephritis. (9034137)
1997
36
Tissue factor in crescentic glomerulonephritis. (9060816)
1997
37
Crucial role of CD8-positive lymphocytes in glomerular expression of ICAM-1 and cytokines in crescentic glomerulonephritis of WKY rats. (9144517)
1997
38
Membranous lupus nephritis with antineutrophil cytoplasmic antibody-associated segmental necrotizing and crescentic glomerulonephritis. (9002540)
1997
39
Modulators of crescentic glomerulonephritis. (8959617)
1996
40
Long-term clinical course in acute crescentic glomerulonephritis. (8899486)
1996
41
Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis associated with thiamazole therapy. (8956314)
1996
42
Renal expression of tissue factor pathway inhibitor and evidence for a role in crescentic glomerulonephritis in rabbits. (8755641)
1996
43
Myeloperoxidase-antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis complicating the course of Graves' disease: report of three adult cases. (7485130)
1995
44
Is the association between crescentic glomerulonephritis and renal cell carcinoma coincidental? (8302427)
1993
45
Methylprednisolone and cyclophosphamide pulse therapy in crescentic glomerulonephritis: safety and effectiveness. (8210561)
1993
46
Crescentic glomerulonephritis related to hepatitis B virus. (1495931)
1992
47
Crescentic glomerulonephritis in children: a review of 43 cases. (1415376)
1992
48
Two distinct types of crescentic glomerulonephritis. (1638779)
1992
49
Crescentic glomerulonephritis in Wegener's granulomatosis: morphology, therapy, outcome. (1873937)
1991
50
Correlation between T cells and experimental crescentic glomerulonephritis. (2125253)
1990

Variations for Crescentic Glomerulonephritis

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Expression for genes affiliated with Crescentic Glomerulonephritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crescentic Glomerulonephritis

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Pathways for genes affiliated with Crescentic Glomerulonephritis

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Compounds for genes affiliated with Crescentic Glomerulonephritis

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46Novoseek, 3BitterDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB
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Compounds related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1chloramphenicol46 3 52 1212.2MPO, SCGB1A1
2heparin46 30 25 1212.1CMA1, MPO, TFPI
3creatinine468.7SCGB1A1, MPO, SYNPO
4alanine468.4DARC, TFPI, SCGB1A1
5calcium46 52 25 1211.0TFPI, SCGB1A1, MPO, CMA1

GO Terms for genes affiliated with Crescentic Glomerulonephritis

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17Gene Ontology
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Cellular components related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.5CMA1, MPO, SCGB1A1
2extracellular spaceGO:0056158.3MPO, SCGB1A1, TNFRSF6B, TFPI

Biological processes related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.2MPO, SCGB1A1
2regulation of inflammatory responseGO:0507279.1CMA1, SCGB1A1
3defense responseGO:0069529.1MPO, DARC

Molecular functions related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.5TNFRSF6B, DARC

Products for genes affiliated with Crescentic Glomerulonephritis

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Sources for Crescentic Glomerulonephritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet