MCID: CRS001
MIFTS: 50

Crescentic Glomerulonephritis malady

Summaries for Crescentic Glomerulonephritis

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a... more...

MalaCards: Crescentic Glomerulonephritis, also known as idiopathic crescentic glomerulonephritis, is related to vasculitis and rapidly progressive glomerulonephritis. An important gene associated with Crescentic Glomerulonephritis is MPO (myeloperoxidase), and among its related pathways are Malaria and LDL Oxidation in Atherogenesis. The compounds pge2 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and kidney, and related mouse phenotypes are renal/urinary system and immune system.

Aliases & Classifications for Crescentic Glomerulonephritis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT
See all sources

Aliases & Descriptions:

crescentic glomerulonephritis 8 10
idiopathic crescentic glomerulonephritis 8 61


External Ids:

Disease Ontology8 DOID:13139
SNOMED-CT57 45406000, 236398000
NCIt40 C35444

Related Diseases for Crescentic Glomerulonephritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Crescentic Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis31.1VCAM1, PRTN3, MPO, MBL2
2rapidly progressive glomerulonephritis31.1MPO, PRTN3
3arthritis30.8CCL4, CCL3, MPO, PRTN3, IL1R1
4nephritis30.6SCGB1A1, MPO, PRTN3, IL1R1, VCAM1
5lupus nephritis30.4VCAM1, MBL2
6down syndrome30.4CCL4
7antiphospholipid syndrome30.1VCAM1
8wegener's granulomatosis30.1PRTN3, MPO
9adenocarcinoma30.1CTNND1, SCGB1A1, TNFRSF6B
10hepatitis c30.1F2R, IL1R1, PRTN3
11systemic lupus erythematosus30.1CCL4, CCL3, MBL2, ITGAL, MPO, PRTN3
12sepsis30.1CCL4, CCL3, MBL2, TFPI, ITGAL, MPO
13graves' disease30.1ITGAL, MPO, VCAM1
14pauci-immune glomerulonephritis10.9
15membranous glomerulonephritis10.6
16immune-complex glomerulonephritis10.6
17anti-basement membrane glomerulonephritis10.6
18n syndrome10.6
19churg-strauss syndrome10.4
20amyloidosis10.4
21amyloidosis, renal10.4
22membranoproliferative glomerulonephritis10.3
23proliferative glomerulonephritis10.3
24bronchiectasis10.3
25polycystic kidney disease10.3
26fabry disease10.3
27tuberculosis10.3
28urticaria10.3
29polymyositis10.3
30diabetic nephropathy10.1
31alport syndrome10.1
32familial mediterranean fever10.1
33granulomatous angiitis10.1
34autoimmune thrombocytopenic purpura10.1
35autoimmune thyroiditis10.1
36papillary carcinoma10.1
37papillary renal cell carcinoma10.1
38henoch-schoenlein purpura10.1
39nail-patella syndrome10.1
40thrombotic thrombocytopenic purpura10.1
41plasmodium vivax malaria10.1
42miliary tuberculosis10.1
43autoimmune hemolytic anemia10.1
44legionnaires' disease10.1
45wilson disease10.1
46cryptococcosis10.1
47focal glomerulosclerosis10.1
48hermansky-pudlak syndrome10.1
49hemolytic-uremic syndrome10.1
50papillary adenoma10.1

Graphical network of the top 20 diseases related to Crescentic Glomerulonephritis:



Diseases related to crescentic glomerulonephritis

Clinical Features for Crescentic Glomerulonephritis

Drugs & Therapeutics for Crescentic Glomerulonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Crescentic Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Crescentic Glomerulonephritis

Search NIH Clinical Center for Crescentic Glomerulonephritis

Search CenterWatch for Crescentic Glomerulonephritis

Genetic Tests for Crescentic Glomerulonephritis

Anatomical Context for Crescentic Glomerulonephritis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Crescentic Glomerulonephritis:

33
Bone marrow, Lymph node, Kidney, Liver, Lung, Thyroid, Breast, Skin, Myeloid, Monocytes, T cells, B cells, Endothelial, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Crescentic Glomerulonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Crescentic Glomerulonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9SCGB1A1, CTNND1, SYNPO, IL1R1, ACTN4, MBL2
2MP:00053879.2VCAM1, CCL3, MBL2, SCGB1A1, TFPI, ITGAL
3MP:00053769.0TFPI, SCGB1A1, MBL2, CCL3, C11orf73, ITGAL

Publications for Crescentic Glomerulonephritis

Sources:
51PubMed
See all sources

Articles related to Crescentic Glomerulonephritis:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Management of crescentic glomerulonephritis: what are the recent advances? (23689584)
2013
2
P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis. (23089744)
2013
3
Myeloperoxidase anti-cytoplasmic antibody related crescentic glomerulonephritis in a patient with IgG3I> monoclonal immunoglobulin deposition disease with membranous features. (22975555)
2012
4
Expression of stem cell marker CD133 in fetal and adult human kidneys and pauci-immune crescentic glomerulonephritis. (21154236)
2011
5
Myeloperoxidase-antineutrophil cytoplasmic antibody-related crescentic glomerulonephritis after treatment for clinically amyopathic dermatomyositis: a coincidental combination or not? (21431898)
2011
6
Rare association of chronic lymphocytic leukemia/small lymphocytic lymphoma, ANCAs, and pauci-immune crescentic glomerulonephritis. (20974512)
2011
7
Crescentic glomerulonephritis and leucocytoclastic vasculitis associated with acute EBV infection. (21793991)
2011
8
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. (21946538)
2011
9
Necrotic crescentic glomerulonephritis and IGA nephropathy: Lee-Haas classification revisited. (21743230)
2011
10
Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. (21403644)
2011
11
ANCA-negative Pauci-immune crescentic glomerulonephritis with thrombotic microangiopathy. (21063645)
2010
12
Renal involvement in leprosy: report of progression from diffuse proliferative to crescentic glomerulonephritis. (20016924)
2010
13
Increased chymase-positive mast cells in children with crescentic glomerulonephritis. (19050935)
2009
14
Scleroderma with crescentic glomerulonephritis: a case report. (18474117)
2008
15
The protective role of uteroglobin through the modulation of tissue transglutaminase in the experimental crescentic glomerulonephritis. (18558621)
2008
16
Periglomerular accumulation of dendritic cells in rat crescentic glomerulonephritis. (17557270)
2007
17
Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis in scleroderma--a different kind of renal crisis. (16832842)
2006
18
CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. (16014035)
2005
19
Crescentic glomerulonephritis associated with renal cell carcinoma after cancer immunotherapy. (16245250)
2005
20
ANCA-negative pauci-immune crescentic glomerulonephritis complicated with recurrent massive gastrointestinal hemorrhage. (15980955)
2005
21
A rare form of crescentic glomerulonephritis with mixed immunopathological features. (15841695)
2004
22
Antineutrophil cytoplasmic antibody-associated necrotizing crescentic glomerulonephritis in a patient receiving treatment with etanercept for severe rheumatoid arthritis. (15481857)
2004
23
ANCA-related crescentic glomerulonephritis in a patient with scleroderma without marked dermatological change and malignant hypertension. (15283187)
2004
24
Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis. (14633134)
2003
25
Impact of clinical and histopathological factors on outcome of Egyptian patients with crescentic glomerulonephritis. (15198164)
2003
26
ANCA-positive crescentic glomerulonephritis associated with minocycline therapy. (12900849)
2003
27
Preexisting crescentic glomerulonephritis in the renal allograft. (14582075)
2003
28
WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. (11912180)
2002
29
Acute and crescentic glomerulonephritis. (12557962)
2002
30
Influenza vaccination induced leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis. (12356192)
2002
31
Fatal pulmonary-renal syndrome manifested with immune complex crescentic glomerulonephritis in a patient with MPO-ANCA seropositivity. (11519085)
2001
32
mRNA expression of urokinase and plasminogen activator inhibitor-1 in human crescentic glomerulonephritis. (11493338)
2001
33
A clinical and pathological study on the characteristics and factors influencing the prognosis of crescentic glomerulonephritis using a cluster analysis. (10504549)
1999
34
SjAPgren's syndrome complicated by MPO-ANCA positive crescentic glomerulonephritis. (10328503)
1999
35
Glomerular expression of cell-cycle-regulatory proteins in human crescentic glomerulonephritis. (10526006)
1999
36
Crescentic glomerulonephritis and centrocytic lymphoma. (10435886)
1999
37
Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cells. (9626058)
1998
38
Transforming growth factor-beta, endothelin-1, and c-fos expression in necrotizing/crescentic IgA glomerulonephritis. (9681709)
1998
39
Myeloperoxidase-antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis complicating the course of Graves' disease: report of three adult cases. (7485130)
1995
40
Pauci-immune crescentic glomerulonephritis and cutaneous vasculitis associated with anti-proteinase 3 antibody. (7774085)
1995
41
Incidence and outcome of pauci-immune necrotizing and crescentic glomerulonephritis in adults. (7774068)
1995
42
Crescentic glomerulonephritis and crystals within glomerular capillaries in an AIDS patient treated with foscarnet. (7618652)
1995
43
Interleukin-1 in crescentic glomerulonephritis. (7564129)
1995
44
Does truly 'idiopathic' crescentic glomerulonephritis exist? (7970088)
1994
45
Multiple myeloma presenting as proliferative (crescentic) glomerulonephritis. (8737563)
1994
46
Production of two novel monoclonal antibodies against human renal glomeruli and their application to the immunohistochemical investigation of crescentic glomerulonephritis. (7931826)
1994
47
Association between silica exposure and necrotizing crescentic glomerulonephritis with p-ANCA and anti-MPO antibodies: a hospital-based case-control study. (8296651)
1993
48
Crescentic transformation in primary membranous glomerulonephritis. (1924031)
1991
49
Effect of enalapril on proteinuria and renal function in patients with healed severe crescentic glomerulonephritis. (1798592)
1991
50
Correlation between T cells and experimental crescentic glomerulonephritis. (2125253)
1990

Genetic Variations for Crescentic Glomerulonephritis

Expression for genes affiliated with Crescentic Glomerulonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Crescentic Glomerulonephritis

Search GEO for disease gene expression data for Crescentic Glomerulonephritis.

Pathways for genes affiliated with Crescentic Glomerulonephritis

Sources:
30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Compounds for genes affiliated with Crescentic Glomerulonephritis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1pge24510.8ITGAL
2endotoxin4510.7VCAM1, SCGB1A1
3estrogen4510.6MBL2, PRTN3
4cyclophosphamide45 50 1112.6MBL2, ITGAL, IL1R1
5glucose4510.5F2R, CCL3
6dexamethasone45 50 29 1113.5F2R, IL1R1, ITGAL
7zymosan4510.5MPO, MBL2, CCL3
8cuprophan4510.5ITGAL, IL1R1, VCAM1
9peptidoglycan45 2911.4IL1R1, MBL2, CCL3, CCL4
10groalpha4510.4CCL4, CCL3, VCAM1
11cytochalasin b4510.4PRTN3, MPO, ITGAL, CCL4
128-isoprostane4510.4VCAM1, MPO, CCL3
13lipoteichoic acid4510.4CCL3, MBL2, IL1R1
14leukotriene b445 60 2412.4IL1R1, MPO, ITGAL, CCL3
15latex4510.4CCL3, MBL2, SCGB1A1, ITGAL, F2R
16hyaluronic acid45 2411.4SCGB1A1, ITGAL, PRTN3, IL1R1, VCAM1
17diphenyleneiodonium4510.3MPO, IL1R1, VCAM1
18paraffin4510.3MBL2, MPO, IL1R1, F2R, CMA1, VCAM1
19simvastatin45 50 60 29 11 2415.3CCL4, CCL3, ITGAL, F2R, VCAM1
20il 104510.3IL1R1, CCL3, CCL4
21sb 20358045 6011.3CCL4, CCL3, IL1R1, F2R, VCAM1
22fmlp4510.3CCL3, ITGAL, MPO, PRTN3, F2R, VCAM1
23rantes4510.3CCL4, CCL3, MBL2, ITGAL, IL1R1, DARC
24creatinine4510.3CCL4, MBL2, SCGB1A1, MPO, SYNPO, IL1R1
25fibrinogen4510.3VCAM1, F2R, IL1R1, ITGAL, MBL2
26histamine45 29 2412.2CCL4, CCL3, CTNND1, MPO, F2R, CMA1
27prednisolone45 29 1112.2CCL4, CCL3, MBL2, ITGAL, MPO, IL1R1
28wortmannin4510.2VCAM1, F2R, ITGAL, CCL3, CCL4
29ionomycin4510.2CCL4, CCL3, ITGAL, PRTN3
30tacrolimus45 50 1112.2CCL4, CCL3, ITGAL, F2R
31superoxide45 2411.2CCL4, MBL2, ITGAL, MPO, PRTN3, F2R
32chloride4510.2F2R, IL1R1, MPO, CCL4
33steroid4510.2CCL4, CCL3, MBL2, SCGB1A1, SYNPO, IL1R1
34n-formylmethionyl-leucylphenylalanine4510.2ITGAL, MPO, PRTN3
35ccl445 2911.2IL1R1, CCL3, CCL4
36oxygen45 2411.1CCL3, MBL2, SCGB1A1, CTNND1, ITGAL, MPO
37phosphatidylinositol4510.1CCL4, TNFRSF6B, SCGB1A1, ITGAL, IL1R1, F2R
38vegf4510.1CCL4, CCL3, MBL2, CTNND1, MPO, IL1R1
39nitric oxide45 11 2412.1CCL4, CCL3, MBL2, SCGB1A1, ITGAL, MPO
40cholesterol45 29 11 2413.1CCL4, CCL3, MBL2, ITGAL, IL1R1, F2R
41ccl345 2911.1CCL4, CCL3, IL1R1
42serine4510.0CCL4, CCL3, CTNND1, TFPI, MPO, PRTN3
43heparin45 29 11 2413.0CCL4, CCL3, TFPI, ITGAL, MPO, IL1R1
44cysteine4510.0CCL4, CCL3, MBL2, ITGAL, IL1R1, F2R
45retinoic acid45 2411.0CCL4, CCL3, ITGAL, MPO, PRTN3, IL1R1
46lipid4510.0MBL2, SCGB1A1, CTNND1, TFPI, ITGAL, PRTN3
47pentoxifylline45 1110.9MPO, IL1R1, VCAM1
48alanine459.8VCAM1, CCL4, CCL3, SCGB1A1, CTNND1, TFPI
49tyrosine459.8CCL4, MBL2, CTNND1, ITGAL, PRTN3, IL1R1
50calcium45 50 11 2412.6CCL4, CCL3, MBL2, SCGB1A1, CTNND1, TFPI

GO Terms for genes affiliated with Crescentic Glomerulonephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.7CCL4, CCL3, MBL2, TFPI, IL1R1, F2R
2extracellular spaceGO:0056159.4CCL4, CCL3, MBL2, TNFRSF6B, SCGB1A1, TFPI

Biological processes related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.3MPO, MBL2
2positive regulation of calcium-mediated signalingGO:05085010.2ITGAL, CCL3, CCL4
3positive regulation of calcium ion transportGO:05192810.2F2R, CCL3, CCL4
4positive regulation of natural killer cell chemotaxisGO:200050310.1CCL3, CCL4
5negative regulation by host of viral transcriptionGO:0439229.9CCL3, CCL4
6inflammatory responseGO:0069549.9CCL4, CCL3, ITGAL, DARC, F2R

Molecular functions related to Crescentic Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:03172610.2CCL3, CCL4
2CCR5 chemokine receptor bindingGO:0317309.9CCL3, CCL4

Products for genes affiliated with Crescentic Glomerulonephritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Crescentic Glomerulonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet