MCID: CRS005
MIFTS: 51

Crest Syndrome malady

Categories: Rare diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Crest Syndrome

Aliases & Descriptions for Crest Syndrome:

Name: Crest Syndrome 12 50 52 42 14 69
Calcinosis-Raynaud Phenomenon-Esophageal Involvement-Sclerodactyly-Telangiectasia Syndrome 50
Calcinosis - Raynaud Phenomenon - Esophageal Involvement - Sclerodactyly - Telangiectasia 50
Systemic Sclerosis, Susceptibility to 50
Scleroderma, Familial Progressive 50
Sclerosis Systemic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0060218
ICD10 33 M34.1
MeSH 42 D017675
NCIt 47 C70646

Summaries for Crest Syndrome

NIH Rare Diseases : 50 crest syndrome, also known as limited scleroderma, is a widespread connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs. the symptoms involved in crest syndrome are associated with the generalized form of the disease systemic sclerosis (scleroderma). crest is an acronym for the clinical features that are seen in a patient with this disease. (c) - calcinosis: calcium deposits in the connective tissues, which can be detected by x ray. they are typically found on the fingers, hands, face, trunk, and on the skin above the elbows and knees. when the deposits break through the skin, painful ulcers can result. (r) - raynaud's phenomenon: a condition in which the small blood vessels of the hands and/or feet contract in response to cold or anxiety. as the vessels contract, the hands or feet turn white and cold, then blue. as blood flow returns, they become red. fingertip tissues may suffer damage, leading to ulcers, scars, or gangrene. (e) - esophageal dysfunction: impaired function of the esophagus (the tube connecting the throat and the stomach) that occurs when smooth muscles in the esophagus lose normal movement. in the upper esophagus, the result can be swallowing difficulties; in the lower esophagus, the problem can cause chronic heartburn or inflammation. (s) - sclerodactyly: thick and tight skin on the fingers, resulting from deposits of excess collagen within skin layers. the condition makes it harder to bend or straighten the fingers. the skin may also appear shiny and darkened, with hair loss. (t) - telangiectasia: small red spots on the hands and face that are caused by the swelling of tiny blood vessels. while not painful, these red spots can create cosmetic problems. it is not necessary to have all five symptoms of crest syndrome to be diagnosed with the disease. some doctors believe only two of the five are necessary for a diagnosis. crest syndrome is believed to be an autoimmune disorder, where the immune system appears to stimulate the production of too much collagen which builds up in the skin and internal organs, impairing their function. there is no cure. current treatment focuses on relieving signs and symptoms and preventing complications. last updated: 12/14/2016

MalaCards based summary : Crest Syndrome, also known as calcinosis-raynaud phenomenon-esophageal involvement-sclerodactyly-telangiectasia syndrome, is related to calcinosis and diffuse scleroderma, and has symptoms including dyspnea, edema and nausea and vomiting. An important gene associated with Crest Syndrome is CENPB (Centromere Protein B), and among its related pathways/superpathways are Phospholipase-C Pathway and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Dopamine and Ropinirole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney, and related phenotypes are cardiovascular system and skeleton

Disease Ontology : 12 A syndrome characterized by calcinosis, Raynaud's phenomeno, esophageal dysmotility, sclerodactyly and telangiectasia.

Wikipedia : 71 CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem... more...

Related Diseases for Crest Syndrome

Diseases related to Crest Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
id Related Disease Score Top Affiliating Genes
1 calcinosis 30.1 CD40LG CTGF EDN1
2 diffuse scleroderma 29.9 CENPB CTGF TOP1
3 porphyria cutanea tarda 29.4 COL1A1 COL1A2
4 scleroderma, familial progressive 11.4
5 limited scleroderma 11.1
6 systemic scleroderma 10.7
7 reynolds syndrome 10.7
8 gastric antral vascular ectasia 10.7
9 mucolipidoses 10.2 CD40LG EDN1
10 hemangioma of orbit 10.1 CD36 CD40LG
11 cngb3-related stargardt disease 1 10.1 COL1A1 COL1A2
12 anhidrosis 10.1 BMP6 CTGF
13 isolated lissencephaly type 1 without known genetic defects 10.1 COL1A1 COL1A2
14 nystagmus, congenital motor, autosomal recessive 10.1 BMP6 FBN1
15 charcot-marie-tooth neuropathy type 2a 10.1 COL1A1 COL1A2
16 prph2-related retinitis pigmentosa 10.1 COL1A1 COL1A2
17 20p13 microdeletion syndrome 10.1 COL1A1 COL1A2
18 epileptic encephalopathy, early infantile, 36 10.1 COL1A1 COL1A2
19 geleophysic dysplasia 2 10.1 COL1A2 CTGF FBN1
20 factor xiiia deficiency 10.1 COL1A1 COL1A2
21 sialadenitis 10.1 CENPB EDN1 RNPC3
22 hemorrhagic cystitis 10.1 BMP6 CD36 CTGF
23 respiratory system disease 10.1 CD40LG CENPB RNPC3
24 osteogenesis imperfecta, type iii 10.1 COL1A1 COL1A2
25 cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2 10.0 COL1A1 COL1A2
26 mass syndrome 10.0 BMP6 COL1A2 FBN1
27 stiff skin syndrome 10.0 FBN1 RNPC3
28 sclerocornea 10.0 COL1A1 COL1A2 FBN1
29 phyh-related refsum disease 10.0 CD36 COL1A1 COL1A2
30 autism susceptibility 16 10.0 COL1A1 COL1A2
31 human herpesvirus 8 10.0 CD36 COL1A1 COL1A2
32 long qt syndrome 1 10.0 CD36 COL1A1 COL1A2
33 muscle hypertrophy 10.0 CD36 COL1A1 COL1A2
34 xanthinuria 10.0 CD36 COL1A1 COL1A2
35 deafness, autosomal recessive 61 10.0 CD36 COL1A1 COL1A2
36 mental retardation, autosomal recessive 35 10.0 CD36 COL1A1 COL1A2
37 osteogenesis imperfecta, type ii 10.0 CD36 COL1A1 COL1A2
38 ehlers-danlos syndrome, cardiac valvular form 10.0 CD36 COL1A1 COL1A2
39 speech and communication disorders 9.9 BMP6 CD36
40 aortic aneurysm, familial thoracic 6 9.9 BMP6 CD36 CTGF EDN1
41 prostatocystitis 9.9 CD36 COL1A1 COL1A2
42 ceroid lipofuscinosis, neuronal, 11 9.9 CD36 CD40LG COL1A1 COL1A2
43 testicular lymphoma 9.8 CD40LG CENPB CTGF EDN1 FBN1 TOP1
44 primary biliary cirrhosis 9.8
45 telangiectasis 9.8
46 nodular regenerative hyperplasia 9.8
47 pulmonary hypertension 9.7
48 herpes simplex 9.7 CENPB COL1A1 COL1A2 CTGF EDN1 TOP1
49 esophagitis 9.6
50 ectropion 9.6

Graphical network of the top 20 diseases related to Crest Syndrome:



Diseases related to Crest Syndrome

Symptoms & Phenotypes for Crest Syndrome

Human phenotypes related to Crest Syndrome:

32 (show all 16)
id Description HPO Frequency HPO Source Accession
1 dyspnea 32 HP:0002094
2 edema 32 HP:0000969
3 nausea and vomiting 32 HP:0002017
4 dysphagia 32 HP:0002015
5 pulmonary fibrosis 32 HP:0002206
6 lack of skin elasticity 32 HP:0100679
7 autoimmunity 32 HP:0002960
8 skin ulcer 32 HP:0200042
9 stiff skin 32 HP:0030053
10 epigastric auras 32 HP:0011159
11 sclerodactyly 32 HP:0011838
12 abnormality of the fingertips 32 HP:0001211
13 lip telangiectasia 32 HP:0000214
14 calcinosis 32 HP:0003761
15 pulmonary arterial hypertension 32 HP:0002092
16 telangiectasia of the skin 32 HP:0100585

MGI Mouse Phenotypes related to Crest Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 AIF1 CD36 CD40LG COL1A1 COL1A2 CTGF
2 skeleton MP:0005390 9.28 FBN1 AIF1 BMP6 CD36 CD40LG COL1A1

Drugs & Therapeutics for Crest Syndrome

Drugs for Crest Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 329)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
2
Ropinirole Approved, Investigational Phase 4,Phase 3 91374-20-8, 91374-21-9 5095 497540
3
Armodafinil Approved, Investigational Phase 4,Phase 3 112111-43-0
4
Modafinil Approved, Investigational Phase 4,Phase 3 68693-11-8 4236
5
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
6
Saquinavir Approved, Investigational Phase 4 127779-20-8 60787
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
8
Ticagrelor Approved Phase 4,Phase 3,Phase 2 274693-27-5 9871419
9
Eluxadoline Approved Phase 4 864821-90-9
10
Loperamide Approved Phase 4 53179-11-6 3955
11
Apixaban Approved Phase 4,Phase 3 503612-47-3 10182969
12
Lopinavir Approved Phase 4 192725-17-0 92727
13
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
14
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
15
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
16 Antiparkinson Agents Phase 4,Phase 3
17 Dopamine Agents Phase 4,Phase 3
18 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
19 Analgesics Phase 4,Phase 3,Phase 2
20 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1
21 Dopamine agonists Phase 4,Phase 3
22 Central Nervous System Stimulants Phase 4,Phase 3
23 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3,Phase 2
24 Wakefulness-Promoting Agents Phase 4,Phase 3
25 Anti-HIV Agents Phase 4
26 Anti-Infective Agents Phase 4,Phase 3,Phase 2
27 Anti-Retroviral Agents Phase 4
28 Antiviral Agents Phase 4,Phase 3,Phase 2
29 Cytochrome P-450 CYP3A Inhibitors Phase 4
30 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
31 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
32
protease inhibitors Phase 4,Phase 3,Phase 2
33 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
34 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
35 Anticoagulants Phase 4,Phase 3,Phase 2
36 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
37 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
38 Antipyretics Phase 4,Phase 3,Phase 2
39 Antirheumatic Agents Phase 4,Phase 3,Phase 2
40 Antithrombin III Phase 4,Phase 3,Phase 2
41 Antithrombins Phase 4,Phase 3,Phase 2
42 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
43 Factor Xa Inhibitors Phase 4,Phase 3,Phase 2
44 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
45 Micronutrients Phase 4,Phase 3,Phase 2
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
47 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
48 Serine Proteinase Inhibitors Phase 4,Phase 3,Phase 2
49 Trace Elements Phase 4,Phase 3,Phase 2
50 Vitamins Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 145)
id Name Status NCT ID Phase
1 Can Resistance Enhance Selection of Treatment? (CREST) Completed NCT00262717 Phase 4
2 12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome Completed NCT00373542 Phase 4
3 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed NCT00518986 Phase 4
4 Saquinavir/Ritonavir in Single Therapy as Maintenance Treatment Completed NCT00379405 Phase 4
5 Efficacy of Eluxadoline in the Treatment of Irritable Bowel Syndrome With Diarrhea in Patients With Inadequate Control of Symptoms With Prior Loperamide Use Recruiting NCT02959983 Phase 4
6 A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart Recruiting NCT02415400 Phase 4
7 An Open-Label, Long-term Study to Assess the Immunogenicity of Linaclotide Administered Orally to Adult Patients With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation Active, not recruiting NCT02590432 Phase 4
8 Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study Active, not recruiting NCT02406677 Phase 4
9 Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion Terminated NCT02476994 Phase 4
10 HIV - Monotherapy in Switzerland (MOST-ch) Terminated NCT00531986 Phase 4
11 Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors Unknown status NCT00566852 Phase 3
12 Pyridoxine and Topical Urea/Lactic Acid-Based Cream in Preventing Hand-Foot Syndrome in Patients Receiving Capecitabine for Breast Cancer or Other Cancer Completed NCT00296036 Phase 3
13 A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects Completed NCT00699998 Phase 3
14 The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial Completed NCT01000727 Phase 3
15 Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome Completed NCT00968708 Phase 3
16 Ropinirole XR (Extended Release) In Patients With Restless Legs Syndrome Completed NCT00197080 Phase 3
17 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) (Protocol JNJ-27018966IBS3001) Completed NCT01553591 Phase 3
18 Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation Completed NCT00948818 Phase 3
19 Study In Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy Completed NCT00067457 Phase 3
20 A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome Completed NCT00391872 Phase 3
21 Efficacy and Safety of Rebamipide in Subjects With Dry Eye Syndrome Completed NCT01632137 Phase 3
22 An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation Completed NCT00765999 Phase 3
23 Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide) Completed NCT01147250 Phase 3
24 Long-Term Safety Of Ropinirole XR In Patients With Restless Legs Syndrome Completed NCT00355641 Phase 3
25 A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome Completed NCT00658515 Phase 3
26 Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome Completed NCT00003593 Phase 3
27 An Efficacy and Safety Study for Rivaroxaban in Patients With Acute Coronary Syndrome Completed NCT00809965 Phase 3
28 Armodafinil (CEP-10953) for Treatment of Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, or Chronic Shift Work Sleep Disorder Completed NCT00078312 Phase 3
29 Study Of Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy Completed NCT00067561 Phase 3
30 Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00369317 Phase 3
31 A Multicenter VESIcare® Efficacy and Safety Study for the Treatment of Urgency Associated With Overactive Bladder (OAB) Completed NCT00454896 Phase 3
32 Efficacy & Safety Study of VESIcare® (Solifenacin Succinate) in Patients Wishing to Switch From Detrol LA® for Treatment of Overactive Bladder Completed NCT00454740 Phase 3
33 Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory Anemia Completed NCT00046930 Phase 3
34 Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Nonmalignant Pain Completed NCT00312195 Phase 3
35 Effect of Otamixaban Versus Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non ST Elevation Myocardial Infarction Undergoing Early Invasive Strategy Completed NCT01076764 Phase 3
36 Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer Completed NCT02311907 Phase 3
37 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3
38 Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed NCT00489411 Phase 3
39 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3
40 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Completed NCT01099449 Phase 3
41 EGb761 in Maintaining Mental Clarity in Women Receiving Chemotherapy for Newly Diagnosed Breast Cancer Completed NCT00046891 Phase 3
42 A Study to Evaluate the Use and Safety of CARDIOLITE® in Pediatric Patients With Kawasaki Disease Completed NCT00162032 Phase 3
43 Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed NCT00516503 Phase 3
44 Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin Completed NCT01225562 Phase 3
45 Vitamin E in Preventing Peripheral Neuropathy Caused by Chemotherapy in Patients Receiving Chemotherapy for Cancer Completed NCT00363129 Phase 3
46 Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus Completed NCT00432276 Phase 3
47 Study of Rebamipide Eye Drops to Treat Dry Eye Completed NCT00201981 Phase 3
48 Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus Completed NCT00225277 Phase 3
49 Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease Completed NCT00195715 Phase 3
50 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3

Search NIH Clinical Center for Crest Syndrome

Cochrane evidence based reviews: crest syndrome

Genetic Tests for Crest Syndrome

Anatomical Context for Crest Syndrome

MalaCards organs/tissues related to Crest Syndrome:

39
Skin, Lung, Kidney, Skeletal Muscle, Smooth Muscle, Liver, Breast

Publications for Crest Syndrome

Articles related to Crest Syndrome:

(show top 50) (show all 61)
id Title Authors Year
1
Crest Syndrome. ( 27072730 )
2016
2
Assessment and Surgical Treatment of Calcinosis of the Shoulder Associated with CREST Syndrome. ( 27437158 )
2016
3
Upper gastrointestinal bleeding (watermelon stomach) in a patient with limited scleroderma (CREST syndrome). ( 27353193 )
2016
4
Complications in Placement of a Glaucoma Drainage Device in a Patient With CREST Syndrome. ( 27811572 )
2016
5
Reversed shunting in CREST syndrome. ( 26678219 )
2015
6
Tinea Incognita in a Patient with Crest Syndrome: Case Report. ( 26476904 )
2015
7
Osteonecrosis of Multiple Joints in a Patient With Limited Scleroderma/CREST Syndrome. ( 25807102 )
2015
8
Telangiectasis in CREST syndrome and systemic sclerosis: correlation of clinical and pathological features with response to pulsed dye laser treatment. ( 23494102 )
2014
9
Oral medicine case book 62: CREST syndrome. ( 26548213 )
2014
10
Cryoglobulinemic vasculitis in a patient with CREST syndrome. ( 24852904 )
2014
11
Pulsed versus continuous wave low-level light therapy on osteoarticular signs and symptoms in limited scleroderma (CREST syndrome): a case report. ( 25393970 )
2014
12
A case of acute autoimmune hepatitis presenting after incomplete-type CREST syndrome and chronic thyroiditis. ( 25195969 )
2014
13
Surgical treatment of extensive subcutaneous calcification of the forearm in CREST syndrome. ( 23849984 )
2013
14
Surgical management of digital calcinosis in CREST syndrome. ( 24142114 )
2013
15
CREST syndrome with pulmonary arterial hypertension. ( 22333384 )
2012
16
Anti-myelin-associated glycoprotein polyneuropathy coexistent with CREST syndrome. ( 22387650 )
2012
17
Peripheral phenomena in a woman with calcinosis, raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome-associated pulmonary hypertension. ( 22392867 )
2012
18
Primary cutaneous cryptococcosis in a patient with CREST syndrome. ( 22381693 )
2012
19
Scleroderma and CREST syndrome: a case report in dentistry. ( 21956352 )
2011
20
Small lymphocytic lymphoma in a patient with CREST syndrome. ( 21982887 )
2011
21
Non-healing leg ulcers in a patient with dystrophic calcification and crest syndrome: a challenging clinical case. ( 21827631 )
2011
22
Livedo reticularis and bowel ischemia after carbon dioxide arteriography in a patient with CREST syndrome. ( 21277800 )
2011
23
Coronary artery abnormalities in CREST syndrome revealed by cardiovascular magnetic resonance imaging. ( 21474271 )
2011
24
Partial breast irradiation in a patient with bilateral breast cancers and CREST syndrome. ( 21349774 )
2011
25
Gastric variceal bleeding uncovering a rare association of CREST syndrome, primary biliary cirrhosis, nodular regenerative hyperplasia and pulmonary hypertension. ( 20485183 )
2010
26
Orbital bone and soft tissue calcification in CREST syndrome. ( 20584022 )
2010
27
Sporadic hemiplegic migraine and CREST syndrome. ( 20130953 )
2010
28
Multiple cerebral aneurysms in a patient with CREST syndrome. ( 20510616 )
2010
29
Pulmonary capillary hemangiomatosis associated with CREST syndrome: a case report and review of the literature. ( 20453487 )
2010
30
Acute central retinal artery occlusion presenting as CREST syndrome: a case report. ( 19123948 )
2009
31
Surgical debridement of painful fingertip calcinosis cutis in CREST syndrome. ( 19221282 )
2009
32
[A case of anti-AQP4 antibody-positive recurrent myelitis overlapped with autoimmune disorders including incomplete CREST syndrome revealed multiple discontinuous cord lesions]. ( 19348177 )
2009
33
Juxtafoveolar telangiectasis associated with CREST syndrome. ( 18716957 )
2008
34
Soft-tissue infection and underlying calcinosis of CREST syndrome. ( 17060652 )
2006
35
Congenital iris ectropion and glaucoma associated with intestinal neuronal dysplasia: a manifestation of a neural crest syndrome. ( 17030723 )
2006
36
Tumoral calcinosis in the cervical spine in a patient with CREST syndrome. A case report. ( 16391265 )
2006
37
Treatment of cutaneous calcinosis in CREST syndrome by extracorporeal shock wave lithotripsy. ( 16227105 )
2005
38
A case of porphyria cutanea tarda in association with idiopathic myelofibrosis and CREST syndrome. ( 11167703 )
2001
39
Immunohistochemical expression of transforming growth factor beta3 in calcinosis in a patient with systemic sclerosis and CREST syndrome. ( 11069531 )
2000
40
Granulomatous anterior uveitis in a patient with CREST syndrome. ( 11120581 )
2000
41
Myasthenia gravis associated with limited scleroderma (CREST syndrome) ( 10701901 )
2000
42
Kinetics of anti-fibrillin-1 autoantibodies in MCTD and CREST syndrome. ( 10756089 )
2000
43
Late-onset unilateral primary developmental glaucoma associated with iridotrabecular dysgenesis, congenital ectropion uveae and thickened corneal nerves: a new neural crest syndrome? ( 10929982 )
1999
44
Dysgenesis of the internal carotid artery associated with transsphenoidal encephalocele: a neural crest syndrome? ( 10445462 )
1999
45
Concomitant spondylarthropathy and CREST syndrome. ( 10609082 )
1999
46
Image of the month. CREST syndrome: calcinosis cutis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis. ( 9178667 )
1997
47
Image interpretation session: 1995. Case 1. Exogenous lipoid pneumonia superimposed on systemic sclerosis with limited scleroderma (CREST syndrome). ( 10946703 )
1996
48
A case of CREST syndrome associated with sick sinus syndrome. ( 8586765 )
1995
49
Autosomal-recessive neural crest syndrome with albinism, black lock, cell migration disorder of the neurocytes of the gut, and deafness: ABCD syndrome. ( 7778600 )
1995
50
Gastric telangiectasis: a rare cause of severe blood loss in CREST syndrome. ( 8183780 )
1994

Variations for Crest Syndrome

Copy number variations for Crest Syndrome from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107132 17 1225928 31649829 Copy number CCL3L3 Sclerosis systemic
2 107142 17 1225928 31649843 Copy number CCL3L1 Sclerosis systemic
3 107162 17 1242109 31665953 Copy number CCL4L2 Sclerosis systemic
4 110231 17 31562580 31665959 Copy number CCL4L1 Sclerosis systemic
5 209408 6 2614953 31491069 Copy number MICA Sclerosis systemic
6 211359 6 32593131 32665540 Copy number HLA-DRB5 Sclerosis systemic
7 212284 6 3674895 32665540 Copy number HLA-DRB1 Sclerosis systemic
8 212430 6 3795995 32719407 Copy number HLA-DQA1 Sclerosis systemic
9 212451 6 3813334 32742444 Copy number HLA-DQB1 Sclerosis systemic

Expression for Crest Syndrome

Search GEO for disease gene expression data for Crest Syndrome.

Pathways for Crest Syndrome

GO Terms for Crest Syndrome

Cellular components related to Crest Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.87 BMP6 CD40LG COL1A1 COL1A2 CTGF EDN1
2 proteinaceous extracellular matrix GO:0005578 9.56 COL1A1 COL1A2 CTGF FBN1
3 collagen trimer GO:0005581 9.33 CD36 COL1A1 COL1A2
4 extracellular space GO:0005615 9.23 BMP6 CD36 CD40LG COL1A1 COL1A2 CTGF
5 collagen type I trimer GO:0005584 8.96 COL1A1 COL1A2

Biological processes related to Crest Syndrome according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.72 COL1A1 COL1A2 FBN1
2 regulation of immune response GO:0050776 9.71 CD40LG COL1A1 COL1A2
3 blood coagulation GO:0007596 9.7 CD36 COL1A1 COL1A2
4 positive regulation of cell migration GO:0030335 9.69 AIF1 COL1A1 EDN1
5 negative regulation of gene expression GO:0010629 9.67 AIF1 CD36 CTGF
6 platelet activation GO:0030168 9.58 CD40LG COL1A1 COL1A2
7 ossification GO:0001503 9.5 BMP6 COL1A1 CTGF
8 endochondral ossification GO:0001958 9.48 BMP6 COL1A1
9 positive regulation of interleukin-12 production GO:0032735 9.46 CD36 CD40LG
10 response to fatty acid GO:0070542 9.43 CD36 CTGF
11 protein heterotrimerization GO:0070208 9.37 COL1A1 COL1A2
12 skin morphogenesis GO:0043589 9.26 COL1A1 COL1A2
13 cellular response to hydroperoxide GO:0071447 9.16 AIF1 CD36
14 cellular response to transforming growth factor beta stimulus GO:0071560 9.13 COL1A1 EDN1 FBN1
15 skeletal system development GO:0001501 9.02 BMP6 COL1A1 COL1A2 EDN1 FBN1

Molecular functions related to Crest Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor binding GO:0048407 8.96 COL1A1 COL1A2
2 extracellular matrix structural constituent GO:0005201 8.8 COL1A1 COL1A2 FBN1

Sources for Crest Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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