MCID: CRT072
MIFTS: 64

Creutzfeldt-Jakob Disease malady

Genetic diseases, Rare diseases, Infectious diseases, Neuronal diseases, Mental diseases categories

Aliases & Classifications for Creutzfeldt-Jakob Disease

About this section
Sources:
46OMIM, 8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 22GTR, 32MedlinePlus, 2CDC, 61UMLS, 33MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Creutzfeldt-Jakob Disease:

Name: Creutzfeldt-Jakob Disease 46 8 9 42 43 44 48 32 61
Variant Creutzfeldt-Jakob Disease 8 42 2
Bovine Spongiform Encephalopathy 8 10 2
Creutzfeldt-Jakob Syndrome 10 22
Creutzfeldt-Jacob Disease 8 42
Creutzfeldt Jakob Disease 8 42
Vcjd 42 2
Cjd 8 42
New Variant Creutzfeldt-Jakob Disease 61
Subacute Spongiform Encephalopathy 8
Creutzfeldt-Jakob Disease, Variant 46
 
Variant Creutzfeldt-Jacob Disease 42
Encephalopathy, Bovine Spongiform 61
Encephalopathy Bovine Spongiform 44
Transmissible Virus Dementia 8
Creutzfeldt Jacob Syndrome 8
Creutzfeldt Jacob Disease 42
Jakob-Creutzfeldt Disease 8
New Variant of Cjd 42
Variant Cjd 42
Nv-Cjd 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
creutzfeldt-jakob disease:
Inheritance: Autosomal dominant,Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Canada),1-9/1000000 (United States); Age of onset: Adult


External Ids:

OMIM46 123400
Disease Ontology8 DOID:5435, DOID:11949
ICD9CM27 046.1
NCIt39 C26802
Orphanet48 204
MESH via Orphanet34 D007562
ICD10 via Orphanet26 A81.0
UMLS via Orphanet62 C0022336
ICD1025 A81.0

Summaries for Creutzfeldt-Jakob Disease

About this section
NIH Rare Diseases:42 Creutzfeldt-jakob disease (cjd) is a rare, degenerative, invariably fatal brain disorder. it affects about one person in every one million people per year worldwide. cjd usually appears in later life and runs a rapid course. typically, onset of symptoms occurs about age 60, and about 90 percent of patients die within 1 year. in the early stages of disease, patients may have failing memory, behavioral changes, lack of coordination and visual disturbances. as the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur.cjd belongs to a family of human and animal diseases known as the transmissible spongiform encephalopathies (tses). spongiform refers to the characteristic appearance of infected brains, which become filled with holes until they resemble sponges under a microscope. cjd is the most common of the known human tses. other human tses include kuru, fatal familial insomnia (ffi), and gerstmann-straussler-scheinker disease (gss). last updated: 2/5/2015

MalaCards based summary: Creutzfeldt-Jakob Disease, also known as variant creutzfeldt-jakob disease, is related to prion disease and kuru, and has symptoms including autosomal dominant inheritance, supranuclear gaze palsy and depression. An important gene associated with Creutzfeldt-Jakob Disease is PRNP (prion protein), and among its related pathways is A-beta Plaque Formation and APP Metabolism. The compounds nogo-66 (1-40) and mog (35-55) have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cerebellum, and related mouse phenotypes are muscle and mortality/aging.

MedlinePlus:32 Creutzfeldt-jakob disease (cjd) is a rare, degenerative brain disorder. symptoms usually start around age 60. memory problems, behavior changes, vision problems, and poor muscle coordination progress quickly to dementia, coma, and death. most patients die within a year. the three main categories of cjd are sporadic cjd, which occurs for no known reason hereditary cjd, which runs in families acquired cjd, which occurs from contact with infected tissue, usually during a medical procedure cattle can get a disease related to cjd called bovine spongiform encephalopathy (bse) or "mad cow disease." there is concern that people can get a variant of cjd from eating beef from an infected animal, but there is no direct proof to support this. nih: national institute of neurological disorders and stroke

CDC:2 New Case of BSE Detected in Canada: On February 12, 2015, the Canadian Food Inspection Agency (CFIA) announced the confirmation of another bovine spongiform encephalopathy (BSE) in a beef cow from Alberta born in March 2009.

NINDS:43 Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder. Typically, onset of symptoms occurs at about age 60. There are three major categories of CJD:

OMIM:46 The human prion diseases occur in inherited, acquired, and sporadic forms. Approximately 15% are inherited and... (123400) more...

Related Diseases for Creutzfeldt-Jakob Disease

About this section

Diseases in the Creutzfeldt-Jakob Disease family:

Familial Creutzfeldt-Jakob Disease Inherited Creutzfeldt-Jakob Disease

Diseases related to Creutzfeldt-Jakob Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1prion disease32.2PRND
2kuru32.1PRNP
3familial creutzfeldt-jakob disease32.1APOE, PRND, PRNP, MSMB
4wernicke encephalopathy31.3TSPO
5scrapie31.2PRND, PRNP, MSMB, CST3
6cerebral amyloid angiopathy30.6APOE, PRNP, CST3
7dementia30.2APOE, TSPO, PRNP, RPS27A, CST3, CRYAB
8herpes simplex30.1RPS27A, CRYAB, CTSD
9amyloidosis29.8APOE, PRNP, RPS27A, CST3, CTSD
10ischemia29.6AHSP, NES, CST3, CRYAB, CTSD
11alzheimer disease28.8APOE, TSPO, PRND, PRNP, RPS27A, CST3
12neuronitis10.9
13tonsillitis10.7
14cerebritis10.7
15encephalitis10.6
16corticobasal degeneration10.6
17inherited creutzfeldt-jakob disease10.6
18genetic prion diseases10.6PRNP
19spasticity10.6
20supranuclear palsy, progressive10.5APOE
21cerebellar ataxia10.5
22aphasia10.5
23spastic paraparesis10.5
24ataxia10.5
25ganglioglioma10.5S100B
26semantic dementia10.4RPS27A
27gerstmann-straussler disease10.4
28status epilepticus10.4
29tropical spastic paraparesis10.4
30akinetic mutism10.4
31mutism10.4
32autoimmune encephalitis10.4
33limbic encephalitis10.4
34myoclonus10.4
35insomnia, fatal familial10.4
36hemangioblastoma10.3S100B, NES
37brooke-spiegler syndrome10.3
38obesity10.3
39severe combined immunodeficiency10.3
40dentatorubro-pallidoluysian atrophy10.3RPS27A, PRNP
41malignant peripheral nerve sheath tumor10.3S100B, NES
42brain disease10.3
43subependymal giant cell astrocytoma10.3CRYAB, S100B
44arteriovenous fistula10.3
45lateral sclerosis10.3
46pilocytic astrocytoma10.3NES, S100B
47spinocerebellar ataxia10.3PRNP, RPS27A
48ependymoma10.3S100B, NES
49sarcoma, synovial10.3NES, S100B
50rheumatoid arthritis10.3

Graphical network of the top 20 diseases related to Creutzfeldt-Jakob Disease:



Diseases related to creutzfeldt-jakob disease

Symptoms for Creutzfeldt-Jakob Disease

About this section

Symptoms by clinical synopsis from OMIM:

123400

Clinical features from OMIM:

123400

HPO human phenotypes related to Creutzfeldt-Jakob Disease:

(show all 20)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 supranuclear gaze palsy HP:0000605
3 depression HP:0000716
4 dementia HP:0000726
5 irritability HP:0000737
6 hallucinations HP:0000738
7 anxiety HP:0000739
8 apathy HP:0000741
9 delusions HP:0000746
10 personality changes HP:0000751
11 hemiparesis HP:0001269
12 confusion HP:0001289
13 myoclonus HP:0001336
14 abnormality of metabolism/homeostasis HP:0001939
15 gait ataxia HP:0002066
16 memory impairment HP:0002354
17 aphasia HP:0002381
18 rapidly progressive HP:0003678
19 loss of facial expression HP:0005327
20 extrapyramidal muscular rigidity HP:0007076

Drugs & Therapeutics for Creutzfeldt-Jakob Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Creutzfeldt-Jakob Disease

Search NIH Clinical Center for Creutzfeldt-Jakob Disease

Genetic Tests for Creutzfeldt-Jakob Disease

About this section

Genetic tests related to Creutzfeldt-Jakob Disease:

id Genetic test Affiliating Genes
1 Jakob-Creutzfeldt Disease22

Anatomical Context for Creutzfeldt-Jakob Disease

About this section

MalaCards organs/tissues related to Creutzfeldt-Jakob Disease:

31
Brain, Testes, Cerebellum, Cortex, Tonsil, Spleen, Appendix, Eye, Spinal cord, Liver, Bone, Heart, Thalamus, Pituitary

Animal Models for Creutzfeldt-Jakob Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Creutzfeldt-Jakob Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.9HLA-DQB1, APOE, PRNP, CST3, CRYAB
2MP:00107687.7CTSD, CRYAB, PRNP, NES, APOE, AHSP
3MP:00053867.6CTSD, HLA-DQB1, APOE, NES, PRND, PRNP
4MP:00053877.5HLA-DQB1, AHSP, APOE, PRND, PRNP, MSMB
5MP:00036316.9HLA-DQB1, APOE, NES, PRND, PRNP, CST3

Publications for Creutzfeldt-Jakob Disease

About this section

Articles related to Creutzfeldt-Jakob Disease:

(show top 50)    (show all 826)
idTitleAuthorsYear
1
Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI), and Alzheimer's disease (AD). (24902808)
2014
2
Hyperacusis as the initial presentation of Creutzfeldt-Jakob disease. (25340084)
2014
3
Investigation of variant Creutzfeldt-Jakob disease implicated organ or tissue transplantation in the United Kingdom. (24770619)
2014
4
Autoimmune encephalitis mimicking Creutzfeldt-Jakob disease. (25566419)
2014
5
Creutzfeldt-Jakob disease mimicking autoimmune encephalitis with CASPR2 antibodies. (25434587)
2014
6
Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease. (23785217)
2013
7
Sporadic Creutzfeldt-Jakob disease in a patient with episodes of nonconvulsive status epilepticus: case report. (22920008)
2012
8
Human prion diseases: from kuru to variant creutzfeldt-jakob disease. (23225013)
2012
9
The first report of RPSA polymorphisms, also called 37/67 kDa LRP/LR gene, in sporadic Creutzfeldt-Jakob disease (CJD). (21838916)
2011
10
Validation of diagnostic criteria for variant Creutzfeldt-Jakob disease. (20517937)
2010
11
An autopsied case of panencephalopathic-type Creutzfeldt-Jakob disease with mutation in the prion protein gene at codon 232 and type 1 prion protein. (19422533)
2009
12
Variant Creutzfeldt-Jakob disease and exposure to fractionated plasma products. (19538514)
2009
13
The role of stress and anxiety in the onset of familial Creutzfeldt-Jakob Disease (CJD): review. (19051123)
2009
14
Striatal [123I] FP-CIT SPECT demonstrates dopaminergic deficit in a sporadic case of Creutzfeldt-Jakob disease. (18638039)
2009
15
Regulatory sequences of the PRNP gene influence susceptibility to sporadic Creutzfeldt-Jakob disease. (17134829)
2007
16
A novel phenotype of sporadic Creutzfeldt-Jakob disease. (18024694)
2007
17
Size frequency distributions of abnormal protein deposits in Alzheimer's disease and variant Creutzfeldt-Jakob disease. (17849360)
2007
18
A new human genotype prone to variant Creutzfeldt-Jakob disease. (16709965)
2006
19
Bovine spongiform encephalopathy, multiple sclerosis, and creutzfeldt-jakob disease are probably autoimmune diseases evoked by Acinetobacter bacteria. (16014559)
2005
20
Involvement of the peripheral nervous system in human prion diseases including dural graft associated Creutzfeldt-Jakob disease. (15716520)
2005
21
Is variant Creutzfeldt-Jakob disease in young children misdiagnosed as Alpers' syndrome? An analysis of a national surveillance study. (15146014)
2004
22
Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. (14962520)
2004
23
Small de novo duplication in the repeat region of the TATA-box-binding protein gene manifest with a phenotype similar to variant Creutzfeldt-Jakob disease. (15521976)
2004
24
Practical aspects of decontamination of the unconventional transmissible agents that cause sporadic and variant Creutzfeldt-Jakob disease and other similar human diseases. (15448715)
2004
25
Creutzfeldt-Jakob disease presenting as progressive supranuclear palsy. (15142229)
2004
26
Variant Creutzfeldt-Jakob disease. (12733426)
2003
27
A potential cerebrospinal fluid and plasmatic marker for the diagnosis of Creutzfeldt-Jakob disease. (12923775)
2003
28
Chorea as a presenting feature of variant Creutzfeldt-Jakob disease. (12815669)
2003
29
Variant Creutzfeldt-Jakob disease. (14535362)
2003
30
Neuropathology of variant Creutzfeldt-Jakob disease. (11862618)
2002
31
BSE and variant Creutzfeldt-Jakob disease: never say never. (12012095)
2002
32
Variant Creutzfeldt-Jakob disease: an unfolding epidemic of misfolded proteins. (12410862)
2002
33
New variant Creutzfeldt-Jakob disease--is our practice safe? (11412169)
2001
34
Quantification of the vacuolation (spongiform change) and prion protein deposition in 11 patients with sporadic Creutzfeldt-Jakob disease. (11761719)
2001
35
Increased incidence of sporadic Creutzfeldt-Jakob disease on the island of Crete associated with a high rate of PRNP 129-methionine homozygosity in the local population. (11506406)
2001
36
The relationship between new variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. (10394138)
1999
37
Prion protein glycotype analysis in familial and sporadic Creutzfeldt-Jakob disease patients. (10483920)
1999
38
New variant Creutzfeldt-Jakob disease is more common in Britain than elsewhere. (9685298)
1998
39
Cerebrospinal fluid neuron-specific enolase as a useful indicator for the early diagnosis of Creutzfeldt-Jakob disease]. (9396368)
1997
40
Apolipoprotein E phenotype frequency and cerebrospinal fluid concentration are not associated with Creutzfeldt-Jakob disease. (8970451)
1996
41
Demyelinating peripheral neuropathy with Creutzfeldt-Jakob disease and mutation at codon 200 of the prion protein gene. (8780103)
1996
42
Iatrogenic Creutzfeldt-Jakob disease in three growth hormone recipients: a neuropathological study. (8072642)
1994
43
Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein. (7937921)
1994
44
Molecular genetic studies of Creutzfeldt-Jakob disease. (7999318)
1994
45
Similar genetic susceptibility in iatrogenic and sporadic Creutzfeldt-Jakob disease. (8113733)
1994
46
Familial Creutzfeldt-Jakob disease in Chile is associated with the codon 200 mutation of the PRNP amyloid precursor gene on chromosome 20. (1469441)
1992
47
Analysis of the PrP gene in a Tunisian family with Creutzfeldt-Jakob disease]. (1780610)
1991
48
An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease. (2159587)
1990
49
Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease. (2171419)
1990
50
Creutzfeldt-Jakob disease: a case with extensive white matter degeneration and optic atrophy. (6191005)
1983

Variations for Creutzfeldt-Jakob Disease

About this section

UniProtKB/Swiss-Prot genetic disease variations for Creutzfeldt-Jakob Disease:

63
id Symbol AA change Variation ID SNP ID
1PRNPp.Asp178AsnVAR_006469
2PRNPp.Val180IleVAR_006470
3PRNPp.Glu200LysVAR_006473
4PRNPp.Arg208HisVAR_006474
5PRNPp.Val210IleVAR_006475
6PRNPp.Met232ArgVAR_006478
7PRNPp.Glu196LysVAR_008749
8PRNPp.Val203IleVAR_008751
9PRNPp.Glu211GlnVAR_008752

Clinvar genetic disease variations for Creutzfeldt-Jakob Disease:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PRNPNM_000311.3(PRNP)NT expansionPathogenicrs367543047
2PRNPNM_000311.3(PRNP): c.385A> G (p.Met129Val)single nucleotide variantPathogenic, risk factorrs1799990GRCh37Chr 20, 4680251: 4680251
3PRNPNM_000311.3(PRNP): c.598G> A (p.Glu200Lys)single nucleotide variantPathogenicrs28933385GRCh37Chr 20, 4680464: 4680464
4PRNPNM_000311.3(PRNP): c.385A> G (p.Met129Val)single nucleotide variantPathogenic, risk factorrs1799990GRCh37Chr 20, 4680251: 4680251
5PRNPNM_000311.3(PRNP): c.628G> A (p.Val210Ile)single nucleotide variantPathogenicrs74315407GRCh37Chr 20, 4680494: 4680494
6PRNPNM_000311.3(PRNP): c.538G> A (p.Val180Ile)single nucleotide variantPathogenicrs74315408GRCh37Chr 20, 4680404: 4680404
7PRNPNM_000311.3(PRNP): c.695T> G (p.Met232Arg)single nucleotide variantPathogenicrs74315409GRCh37Chr 20, 4680561: 4680561
8PRNPNM_000311.3(PRNP): c.623G> A (p.Arg208His)single nucleotide variantPathogenicrs74315412GRCh37Chr 20, 4680489: 4680489
9PRNPNM_000311.3(PRNP): c.532G> A (p.Asp178Asn)single nucleotide variantPathogenicrs74315403GRCh37Chr 20, 4680398: 4680398
10PRNPNM_000311.3(PRNP): c.631G> C (p.Glu211Gln)single nucleotide variantPathogenicrs398122370GRCh37Chr 20, 4680497: 4680497

Expression for genes affiliated with Creutzfeldt-Jakob Disease

About this section
Search GEO for disease gene expression data for Creutzfeldt-Jakob Disease.

Pathways for genes affiliated with Creutzfeldt-Jakob Disease

About this section

Pathways related to Creutzfeldt-Jakob Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CTSD, CST3

Compounds for genes affiliated with Creutzfeldt-Jakob Disease

About this section

Compounds related to Creutzfeldt-Jakob Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1nogo-66 (1-40)6010.2S100B, PRNP
2mog (35-55)6010.2PRNP, S100B
3ono 25066010.1PRNP, S100B
4edss4410.1APOE, S100B
5plp (139-151)6010.1PRNP, S100B
6c3bot (154-182)6010.1S100B, PRNP
7thioflavine s4410.0APOE, RPS27A
8pentylenetetrazol449.9TSPO, S100B
9formate449.8APOE, PRNP, RPS27A
10streptozotocin449.6APOE, NES, RPS27A
11cysteamine44 24 1111.5RPS27A, CTSD, APOE
12guanidine hydrochloride449.5APOE, RPS27A, MSMB, PRNP
13sodium dodecylsulfate449.5RPS27A, APOE, PRNP
14kainate44 2810.5APOE, NES, TSPO
15histidine449.4S100B, PRNP, HLA-DQB1, CTSD
16chloroquine44 1 50 28 1113.3CTSD, RPS27A, APOE
17formaldehyde44 2410.2PRNP, S100B, RPS27A, CTSD
18gaba449.1S100B, RPS27A, TSPO, NES
19indomethacin44 28 60 1112.1TSPO, APOE, AHSP, RPS27A
20heparin44 28 24 1112.0S100B, AHSP, APOE, PRNP, CTSD
216-hydroxydopamine449.0RPS27A, CTSD, CST3
22agarose448.9CST3, S100B, CTSD, PRNP
23homocysteine44 249.8CST3, AHSP, APOE
24silver448.8RPS27A, CST3, CTSD
25p003448.8CST3, S100B, CTSD
26iron44 249.6PRNP, CST3, AHSP, S100B
27cholesterol44 28 24 1111.5PRNP, CTSD, APOE, AHSP, CST3
28acetylcholine44 50 28 24 1112.5S100B, NES, TSPO, RPS27A, APOE, AHSP
29dopamine44 28 24 1111.5TSPO, S100B, RPS27A, AHSP, APOE, NES
30testosterone44 60 24 1111.4RPS27A, TSPO, S100B, CTSD, APOE, MSMB
31lipid448.3S100B, CST3, NES, AHSP, APOE, PRNP
32oxygen44 249.3AHSP, NES, S100B, CTSD, PRNP
33valine448.2CTSD, S100B, RPS27A, PRNP, PRND, TSPO
34h2o2448.2TSPO, CTSD, RPS27A, PRNP, CRYAB, APOE
35alanine448.1APOE, CTSD, CST3, S100B, RPS27A, PRNP
36methionine448.1PRND, PRNP, CST3, CRYAB, S100B, CTSD
37vegf448.0NES, RPS27A, CST3, S100B, CTSD, APOE
38paraffin448.0CTSD, APOE, PRNP, RPS27A, CRYAB, NES
39estrogen448.0APOE, RPS27A, AHSP, TSPO, NES, S100B
40cyclosporin a44 28 609.9CTSD, S100B, CST3, APOE, TSPO, RPS27A
41creatinine447.9TSPO, RPS27A, CST3, S100B, CTSD, APOE
42serine447.9S100B, CST3, PRNP, CTSD, RPS27A, APOE
43arginine447.8PRNP, CST3, S100B, TSPO, APOE, AHSP
44steroid447.8CST3, CTSD, S100B, CRYAB, MSMB, TSPO
45glucose447.8CTSD, AHSP, NES, CST3, CRYAB, S100B
46cysteine447.7RPS27A, AHSP, CTSD, APOE, MSMB, S100B
47calcium44 50 24 1110.5CST3, S100B, CTSD, MSMB, PRNP, AHSP
48glutamate447.5HLA-DQB1, AHSP, APOE, NES, TSPO, PRNP
49aspartate447.3S100B, HLA-DQB1, APOE, PRNP, RPS27A, CTSD
50glutamine447.1TSPO, CTSD, S100B, CRYAB, CST3, APOE

GO Terms for genes affiliated with Creutzfeldt-Jakob Disease

About this section

Cellular components related to Creutzfeldt-Jakob Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.2CTSD, S100B, CST3, MSMB, APOE
2extracellular vesicular exosomeGO:00700626.7CTSD, APOE, TSPO, PRNP, RPS27A, CST3

Biological processes related to Creutzfeldt-Jakob Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:00140129.8TSPO, APOE
2regulation of neuronal synaptic plasticityGO:00481689.8S100B, APOE
3learning or memoryGO:00076119.6S100B, PRNP
4protein homooligomerizationGO:00512609.2PRND, PRNP, CRYAB
5agingGO:00075689.2CRYAB, TSPO, APOE
6positive regulation of apoptotic processGO:00430659.2S100B, RPS27A, TSPO

Molecular functions related to Creutzfeldt-Jakob Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:00481569.7S100B, APOE
2beta-amyloid bindingGO:00015409.4CST3, APOE
3identical protein bindingGO:00428028.7S100B, CRYAB, PRNP, APOE

Sources for Creutzfeldt-Jakob Disease

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet