MCID: CRB006
MIFTS: 39

Cribriform Carcinoma malady

Categories: Cancer diseases

Aliases & Classifications for Cribriform Carcinoma

Aliases & Descriptions for Cribriform Carcinoma:

Name: Cribriform Carcinoma 12 14
Ductal Carcinoma, Cribriform Type 12
Carcinoma, Cribriform 69
Carcinoma Cribriform 52

Classifications:



External Ids:

Disease Ontology 12 DOID:5675
MeSH 42 D000230
NCIt 47 C3680
SNOMED-CT 64 30156004
UMLS 69 C0205643

Summaries for Cribriform Carcinoma

MalaCards based summary : Cribriform Carcinoma, also known as ductal carcinoma, cribriform type, is related to salivary gland adenoid cystic carcinoma and marfanoid hypermobility syndrome. An important gene associated with Cribriform Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Signaling by ERBB4 and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and bone, and related phenotypes are embryo and integument

Related Diseases for Cribriform Carcinoma

Diseases related to Cribriform Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 salivary gland adenoid cystic carcinoma 10.9
2 marfanoid hypermobility syndrome 10.2 KIT PGR
3 skin angiosarcoma 10.2 KIT PGR
4 liver angiosarcoma 10.2 KIT PGR
5 intestinal neuroendocrine benign tumor 10.2 KIT PGR
6 sebaceous adenoma 10.2 KIT PGR
7 ovarian embryonal carcinoma 10.2 KIT PGR
8 laryngeal neuroendocrine tumor 10.2 KIT PGR
9 reactive arthritis 10.2 KIT PGR
10 fitz-hugh-curtis syndrome 10.1 KIT PGR
11 bartholin's gland benign neoplasm 10.1 ESR1 PGR
12 cardiovascular organ benign neoplasm 10.1 ESR1 PGR
13 appendix leiomyoma 10.1 ESR1 PGR
14 bronchus adenoma 10.1 ESR1 PGR
15 glioma 10.1 ESR1 PGR
16 ovarian benign neoplasm 10.1 ESR1 PGR
17 plexiform neurofibroma 10.1 ESR1 PGR
18 paranasal sinus disease 10.1 ESR1 PGR
19 deafness, autosomal recessive 21 10.1 ESR1 PGR
20 cervical lymphoepithelioma-like carcinoma 10.1 ESR1 PGR
21 pneumonia 10.1 KIT PGR
22 histiocytic and dendritic cell cancer 10.1 ESR1 PGR
23 pediatric intraocular retinoblastoma 10.1 ESR1 PGR
24 congenital disorder of glycosylation, type ic 10.1 ESR1 PGR
25 her2-receptor negative breast cancer 10.1 ESR1 PGR
26 intestinal perforation 10.1 ESR1 PGR
27 perlman syndrome 10.1 ESR1 PGR
28 nervous system hibernoma 10.1 ESR1 PGR
29 bladder adenocarcinoma 10.1 ESR1 PGR
30 anal neuroendocrine tumor 10.1 ESR1 PGR
31 osteogenesis imperfecta 10.1 ESR1 PGR
32 poliomyelitis 10.1 ESR1 PGR
33 villoglandular endometrial endometrioid adenocarcinoma 10.1 ESR1 PGR
34 vaginal adenosarcoma 10.1 ESR1 PGR
35 intraneural perineurioma 10.1 ESR1 PGR
36 paraphimosis 10.1 ESR1 PGR
37 central nervous system mature teratoma 10.1 ESR1 PGR
38 acute thyroiditis 10.1 ESR1 PGR
39 mucoepidermoid esophageal carcinoma 10.1 ESR1 PGR
40 perinatal jaundice due to hepatocellular damage 10.1 ESR1 PGR
41 combined t cell and b cell immunodeficiency 10.1 ESR1 PGR
42 deafness, autosomal recessive 74 10.1 ESR1 PGR
43 anomalous left coronary artery from the pulmonary artery 10.1 ESR1 PGR
44 adult neuronal ceroid lipofuscinosis 10.1 ESR1 PGR
45 vulvar alveolar soft part sarcoma 10.1 ESR1 PGR
46 male reproductive organ benign neoplasm 10.1 ESR1 PGR
47 central nervous system primitive neuroectodermal neoplasm 10.1 ESR1 PGR
48 ovarian clear cell malignant adenofibroma 10.1 ESR1 PGR
49 polyembryoma of the ovary 10.1 ESR1 PGR
50 osteoblastoma 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Cribriform Carcinoma:



Diseases related to Cribriform Carcinoma

Symptoms & Phenotypes for Cribriform Carcinoma

MGI Mouse Phenotypes related to Cribriform Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.71 ESR1 KIT PGR TP63
2 integument MP:0010771 9.67 PGR TP63 ESR1 KIT
3 limbs/digits/tail MP:0005371 9.62 ESR1 KIT PGR TP63
4 muscle MP:0005369 9.56 ESR1 KIT PGR TP63
5 neoplasm MP:0002006 9.46 ESR1 KIT PGR TP63
6 no phenotypic analysis MP:0003012 9.26 ESR1 KIT PGR TP63
7 normal MP:0002873 8.92 ESR1 KIT PGR TP63

Drugs & Therapeutics for Cribriform Carcinoma

Drugs for Cribriform Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 168)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved Phase 2, Phase 3 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 22916-47-8 4189
3
Cevimeline Approved Phase 3 107233-08-9 83898 25137844
4
Megestrol acetate Approved, Vet_approved Phase 3 595-33-5 11683
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
6
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
7
Doxepin Approved Phase 3 1668-19-5 667477 667468
8
Docetaxel Approved May 1996, Investigational Phase 3,Phase 2,Phase 1 114977-28-5 148124 9877265
9 Alkylating Agents Phase 3,Phase 2,Phase 1
10 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
11 Anti-Infective Agents Phase 2, Phase 3,Phase 1
12 Liver Extracts Phase 3,Phase 2,Phase 1
13 Porfiromycin Phase 3
14
Megestrol Phase 3 3562-63-8 19090 3080587
15 pancreatic polypeptide Phase 3,Phase 1
16 Analgesics Phase 3
17 Mitomycins Phase 3
18 Cholinergic Agents Phase 3
19 Adjuvants, Anesthesia Phase 3
20 Narcotics Phase 3
21 Neurotransmitter Agents Phase 3
22 Steroid Synthesis Inhibitors Phase 2, Phase 3
23 Contraceptive Agents Phase 3
24 Contraceptives, Oral Phase 3
25 Cytochrome P-450 CYP2C9 Inhibitors Phase 2, Phase 3
26 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Phase 2
27 Analgesics, Opioid Phase 3
28 Hormone Antagonists Phase 2, Phase 3
29 Anesthetics Phase 3
30 Hormones Phase 2, Phase 3,Phase 1
31 Anesthetics, General Phase 3
32 Anesthetics, Intravenous Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
35 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
36 Antifungal Agents Phase 2, Phase 3,Phase 1
37 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
38 Antimitotic Agents Phase 3,Phase 2,Phase 1
39 Appetite Stimulants Phase 3
40 Autonomic Agents Phase 3
41 Antineoplastic Agents, Hormonal Phase 3,Phase 2
42 Central Nervous System Depressants Phase 3
43 Central Nervous System Stimulants Phase 3
44
Histamine Phosphate Phase 3 51-74-1 65513
45 Histamine Antagonists Phase 3
46 Antidepressive Agents Phase 3
47 Antidepressive Agents, Tricyclic Phase 3
48 Psychotropic Drugs Phase 3
49 Cola Nutraceutical Phase 3,Phase 2,Phase 1
50
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622

Interventional clinical trials:

(show top 50) (show all 109)
id Name Status NCT ID Phase
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
2 Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer Completed NCT00002507 Phase 3
3 Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer Completed NCT00090337 Phase 3
4 Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer Completed NCT00017511 Phase 3
5 Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed NCT00002533 Phase 2, Phase 3
6 Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract Completed NCT00765440 Phase 3
7 Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer Completed NCT00006799 Phase 3
8 Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Active, not recruiting NCT01156142 Phase 3
9 Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors Not yet recruiting NCT02838602 Phase 3
10 Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery Withdrawn NCT00041171 Phase 3
11 Study of Imatinib (Glivec) in Patients With Adenoid Cystic Carcinoma of the Head and Neck Unknown status NCT00180921 Phase 2
12 Antineoplaston Therapy in Treating Patients With Advanced Head and Neck Cancer Unknown status NCT00003489 Phase 2
13 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2
14 A Study of Sunitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands Completed NCT00886132 Phase 2
15 Phase II Trial of Doxorubicin and Bortezomib in Patients With Incurable Adenoid Cystic Carcinoma of the Head and Neck Completed NCT00581360 Phase 2
16 Study of RAD001 in Adenoid Cystic Carcinoma Completed NCT01152840 Phase 2
17 Axitinib (AG-013736) in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma Completed NCT01558661 Phase 2
18 Dovitinib in Adenoid Cystic Carcinoma Completed NCT01417143 Phase 2
19 Study of Dovitinib (TKI258) in Adenoid Cystic Carcinoma Completed NCT01524692 Phase 2
20 A Phase II Study of Dovitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands Completed NCT01678105 Phase 2
21 Bortezomib Followed by the Addition of Doxorubicin at Disease Progression in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma (Cancer) of the Head and Neck Completed NCT00077428 Phase 2
22 Gemcitabine in Treating Patients With Recurrent or Metastatic Adenoid Cystic Cancer of the Head and Neck Completed NCT00017498 Phase 2
23 Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers Completed NCT00095563 Phase 2
24 Imatinib Mesylate in Treating Patients With Salivary Gland Cancer Completed NCT00045669 Phase 2
25 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2
26 Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer Completed NCT00101348 Phase 1, Phase 2
27 High-dose ICE With Amifostine Completed NCT00003657 Phase 2
28 Docetaxel in Treating Patients With Solid Tumors Completed NCT00003565 Phase 2
29 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2
30 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer Completed NCT00004901 Phase 1, Phase 2
31 Oxaliplatin and Capecitabine in Treating Patients With Relapsed or Metastatic Head and Neck Cancer Completed NCT00448552 Phase 2
32 Epirubicin, Carboplatin, and Capecitabine in Treating Patients With Unresectable Locally Advanced, Metastatic, or Recurrent Solid Tumor Completed NCT00021047 Phase 1, Phase 2
33 Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors Completed NCT00019331 Phase 2
34 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2
35 Cisplatin or Carboplatin Combined With Gemcitabine in Treating Patients With Locally Advanced, Recurrent, or Metastatic Malignant Salivary Gland Tumor Completed NCT00079079 Phase 2
36 Trastuzumab in Treating Patients With Advanced Salivary Gland Cancer Completed NCT00004163 Phase 2
37 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2
38 Gemcitabine and Doxorubicin in Treating Patients With Recurrent or Progressive Head and Neck Cancer Completed NCT00509665 Phase 2
39 Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer Completed NCT00021333 Phase 2
40 Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma Recruiting NCT03087019 Phase 2
41 A Study of Apatinib in Metastatic Adenoid Cystic Carcinoma of the Head and Neck Recruiting NCT02775370 Phase 2
42 Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy Recruiting NCT01192087 Phase 1, Phase 2
43 Study of Axitinib in Patients With Recurred or Metastatic Adenoid Cystic Carcinoma Recruiting NCT02859012 Phase 2
44 Nivolumab and Ipilimumab in Treating Patients With Metastatic Recurrent Major or Minor Salivary Gland Cancer Recruiting NCT03146650 Phase 2
45 Study of Nivolumab Plus Ipilimumab in Patients With Salivary Gland Cancer Recruiting NCT03172624 Phase 2
46 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Recruiting NCT01586767 Phase 2
47 18F FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy Recruiting NCT01806675 Phase 1, Phase 2
48 Regorafenib in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma Active, not recruiting NCT02098538 Phase 2
49 Testing Lenvatinib in Patients With Adenoid Cystic Carcinoma Active, not recruiting NCT02780310 Phase 2
50 Lenvatinib in Recurrent and/or Metastatic Adenoid Cystic Carcinomas of the Salivary Glands: ACC-LEN14 Active, not recruiting NCT02860936 Phase 2

Search NIH Clinical Center for Cribriform Carcinoma

Genetic Tests for Cribriform Carcinoma

Anatomical Context for Cribriform Carcinoma

MalaCards organs/tissues related to Cribriform Carcinoma:

39
Breast, Prostate, Bone, Colon, Pancreas

Publications for Cribriform Carcinoma

Articles related to Cribriform Carcinoma:

(show all 28)
id Title Authors Year
1
Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. ( 25789036 )
2015
2
Clinicopathological Characteristics and Survival Outcomes of Invasive Cribriform Carcinoma of Breast: A SEER Population-Based Study. ( 26252312 )
2015
3
Primary cutaneous cribriform carcinoma: report of six cases with clinicopathologic data and immunohistochemical profile. ( 25732813 )
2015
4
Colonic Cribriform Carcinoma, a Morphologic Pattern Associated With Low Survival. ( 25015669 )
2014
5
Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort. ( 24703897 )
2014
6
Invasive cribriform carcinoma of the breast: mammographic, sonographic, MRI, and 18a88F-FDG PET-CT features. ( 24938660 )
2014
7
Cribriform carcinoma mimicking breast abscess - case report. Diagnostic and therapeutic management. ( 26674469 )
2013
8
Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. ( 23412348 )
2013
9
Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report. ( 23110003 )
2012
10
Primary cutaneous cribriform carcinoma of the neck: a case report. ( 23316623 )
2012
11
A pure invasive cribriform carcinoma of the breast with bone metastasis if untreated for thirteen years: a case report and literature review. ( 23167837 )
2012
12
Sonographic findings of invasive cribriform carcinoma of the breast. ( 21527619 )
2011
13
Cutaneous cribriform carcinoma: a short comment. ( 21315957 )
2011
14
Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases. ( 18769339 )
2008
15
Grading of invasive cribriform carcinoma on prostate needle biopsy: an interobserver study among experts in genitourinary pathology. ( 18724248 )
2008
16
Immunohistochemical phenotype of cutaneous cribriform carcinoma with a panel of 15 antibodies. ( 18085381 )
2007
17
Report on a case of pure cribriform carcinoma of the breast with internal mammary node metastasis: description of the case and review of the literature. ( 16869243 )
2006
18
Invasive cribriform carcinoma with extensive microcalcifications in the male breast. ( 15858447 )
2005
19
Primary cutaneous cribriform carcinoma: a rare apocrine tumour. ( 16115058 )
2005
20
A case report of cribriform carcinoma of the pancreas with long time survival. ( 11268983 )
2001
21
Fine needle aspiration cytology of invasive cribriform carcinoma of the breast with osteoclastlike giant cells: a case report. ( 11480724 )
2001
22
Cribriform carcinoma of the prostate and cribriform prostatic intraepithelial neoplasia: incidence and clinical implications. ( 9669346 )
1998
23
Infiltrating cribriform carcinoma of the breast. A clinico-pathologic and immunohistochemical study of 5 cases. ( 8780923 )
1996
24
The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team. ( 7955831 )
1994
25
Light and electron microscopic study of an invasive cribriform carcinoma with extensive microcalcification developing in a breast with silicone augmentation. ( 7810003 )
1994
26
Fine needle aspiration of invasive cribriform carcinoma with benign osteoclast-like giant cells of histiocytic origin. A case report. ( 8191846 )
1994
27
Infiltrating cribriform carcinoma of the breast: a distinctive clinicopathologic entity. ( 2312110 )
1990
28
Invasive cribriform carcinoma of the breast. ( 6884999 )
1983

Variations for Cribriform Carcinoma

Expression for Cribriform Carcinoma

Search GEO for disease gene expression data for Cribriform Carcinoma.

Pathways for Cribriform Carcinoma

GO Terms for Cribriform Carcinoma

Biological processes related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.43 ESR1 KIT
2 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.4 ESR1 KIT
3 chromatin remodeling GO:0006338 9.37 ESR1 TP63
4 steroid hormone mediated signaling pathway GO:0043401 9.32 ESR1 PGR
5 positive regulation of Notch signaling pathway GO:0045747 9.26 KIT TP63
6 stem cell differentiation GO:0048863 9.16 ESR1 KIT
7 epithelial cell development GO:0002064 8.96 ESR1 TP63
8 positive regulation of phospholipase C activity GO:0010863 8.62 ESR1 KIT

Molecular functions related to Cribriform Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.54 ESR1 PGR TP63
2 ATPase binding GO:0051117 9.32 ESR1 PGR
3 steroid hormone receptor activity GO:0003707 9.26 ESR1 PGR
4 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.16 ESR1 PGR
5 steroid binding GO:0005496 8.96 ESR1 PGR
6 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 8.8 ESR1 PGR TP63

Sources for Cribriform Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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