CCHF
MCID: CRM001
MIFTS: 64

Crimean-Congo Hemorrhagic Fever (CCHF) malady

Infectious diseases category

Summaries for Crimean-Congo Hemorrhagic Fever

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8Disease Ontology, 3CDC, 32MalaCards
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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, has material basis in crimean-congo hemorrhagic fever virus, which is transmitted by hyalomma ticks. the infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards: Crimean-Congo Hemorrhagic Fever, also known as crimean hemorrhagic fever, is related to encephalitis and cholecystitis, and has symptoms including joint pain, vomiting and jaundice. An important gene associated with Crimean-Congo Hemorrhagic Fever is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Leishmaniasis and Legionellosis. The compounds cycloheximide and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related mouse phenotypes are respiratory system and muscle.

CDC:3 Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was first characterized in the Crimea in 1944 and given the name Crimean hemorrhagic fever. It was then later recognized in 1969 as the cause of illness in the Congo, thus resulting in the current name of the disease.

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
crimean-congo hemorrhagic fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

crimean-congo hemorrhagic fever 8 10 48
crimean hemorrhagic fever 8 48
congo hemorrhagic fever 48 60
congo-crimean hemorrhagic fever 8
hemorrhagic fever crimean-congo 44
hemorrhagic fever, crimean 60
chf congo virus 8
congo fever 48
cchf 48


External Ids:

Disease Ontology8 DOID:12287
MeSH34 D006479
NCIt39 C34682
ICD9CM27 065.0
SNOMED-CT56 43489008
ICD10 via Orphanet26 A98.0
SNOMED-CT via Orphanet57 43489008
ICD1025 A98.0

Related Diseases for Crimean-Congo Hemorrhagic Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Clinical Features for Crimean-Congo Hemorrhagic Fever

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8Disease Ontology
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Symptoms:

8 (show all 37)
  • joint pain
  • vomiting
  • jaundice
  • headache
  • liver/hepatic steatosis
  • leukopenia/hypoleukocytosis
  • nosebleeds
  • back pain
  • stomach pain
  • red eyes
  • high fever
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • blood in the feces
  • acute diarrhea
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • cough
  • thoracic/chest pain
  • cutaneous rash
  • hepatitis/icterus/cholestasis
  • fever/chilling
  • asthenia/fatigue/weakness
  • early death/lethality
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • myalgia/muscular pain
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • epistaxis/nose bleeding
  • pharyngitis
  • abnormal hepatic enzymes/transaminases
  • purpura/petichiae
  • facial pain/cephalalgia/migraine
  • thrombocytopenia/thrombopenia
  • gingivorrhagia/gingival bleeding
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Crimean-Congo Hemorrhagic Fever

Drug clinical trials:

Search ClinicalTrials for Crimean-Congo Hemorrhagic Fever

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Search CenterWatch for Crimean-Congo Hemorrhagic Fever

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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32MalaCards
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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

32
Eye, Liver, Testes, Endothelial, Heart

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.6CASP3, STAB2, VEGFA, IL6
2MP:00053699.5CASP3, STAB2, F3, PARVA
3MP:00107719.3CASP3, MBTPS1, TNFRSF19, VEGFA, IL6, F2
4MP:00053909.3CASP3, MBTPS1, VEGFA, IL6
5MP:00053819.0CASP3, MBTPS1, TNF, VEGFA, NFKB1, IL6
6MP:00053829.0NFKB1, VEGFA, TNF, TNFRSF19, MBTPS1, CASP3
7MP:00053859.0CASP3, TNFRSF19, STAB2, F3, F2, PARVA
8MP:00053878.5CASP3, TLR8, MBTPS1, TNF, CHIT1, VEGFA
9MP:00053768.5PARVA, TLR8, MBTPS1, TNFRSF19, STAB2, NFKB1
10MP:00053788.2CASP3, MBTPS1, TNF, VEGFA, NFKB1, IL6
11MP:00107687.7STAB2, TNF, MBTPS1, CASP3, VEGFA, NFKB1

Publications for Crimean-Congo Hemorrhagic Fever

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50PubMed
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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 384)
idTitleAuthorsYear
1
Temporal modeling of Crimean-Congo hemorrhagic fever in eastern Iran. (23474177)
2013
2
Factors associated with IgG positivity to Crimean-Congo hemorrhagic fever virus in the area with the highest seroprevalence in Greece. (23831367)
2013
3
Crimean-Congo hemorrhagic fever in Iran. (23872313)
2013
4
Close contact precautions could prevent an outbreak of crimean-congo hemorrhagic Fever: a case series report from southern part of tehran. (23930191)
2013
5
Seroprevalence of Crimean-Congo hemorrhagic fever virus, Bulgaria. (23260369)
2013
6
A seroepidemiological survey of Crimean Congo hemorrhagic fever among cattle in North Kordufan State, Sudan. (23738961)
2013
7
Anterior rhinomanometry and determination of nasal mucociliary clearance time with the saccharin test in children with Crimean-Congo hemorrhagic fever. (23714976)
2013
8
Spatial analysis of Crimean Congo hemorrhagic fever in iran. (24166038)
2013
9
Complete genome sequences of two crimean-congo hemorrhagic Fever viruses isolated in china. (23908296)
2013
10
Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya. (22925021)
2012
11
Bacterial expression of Crimean-Congo hemorrhagic fever virus nucleoprotein and its evaluation as a diagnostic reagent in an indirect ELISA. (22001274)
2012
12
Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries. (22482717)
2012
13
Re-evaluation of 400 Crimean-Congo hemorrhagic fever cases in an endemic area: is ribavirin treatment suitable? (22007611)
2012
14
Interleukin-12 (IL-12)/IL-10 ratio as a marker of disease severity in Crimean-Congo hemorrhagic fever. (22539564)
2012
15
Unraveling the ecological complexities of tick-associated Crimean-Congo hemorrhagic fever virus transmission: a gap analysis for the western Palearctic. (22448676)
2012
16
In situ rolling circle amplification detection of Crimean Congo hemorrhagic fever virus (CCHFV) complementary and viral RNA. (22341783)
2012
17
Cardiac findings in children with Crimean-Congo hemorrhagic fever. (21804465)
2011
18
Species diversity of ixodid ticks feeding on humans in Amasya, Turkey: seasonal abundance and presence of Crimean-Congo hemorrhagic fever virus. (21337953)
2011
19
A case of Crimean Congo hemorrhagic fever complicated with acalculous cholecystitis and intraabdominal abscess. (21044860)
2011
20
Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. (20005156)
2010
21
Early serodiagnosis of acute human Crimean-Congo hemorrhagic fever virus infections by novel capture assays. (20541967)
2010
22
Serum levels of Mannan-binding lectin in patients with Crimean-Congo hemorrhagic fever. (20426687)
2010
23
The complete genome analysis of Crimean-Congo hemorrhagic fever virus isolated in Turkey. (19941917)
2010
24
Crimean-Congo hemorrhagic fever virus as a nosocomial pathogen in Iran. (19815885)
2009
25
Ecology of the Crimean-Congo hemorrhagic fever endemic area in Albania. (19402760)
2009
26
The first clinical case due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus and a field survey. (19515251)
2009
27
Ribavirin in crimean-congo hemorrhagic fever: primum non nocere. (19857172)
2009
28
Public Knowledge and Attitude toward Crimean Congo Hemorrhagic Fever in Tokat Turkey. (22808377)
2009
29
Crimean-Congo hemorrhagic fever: does it involve the heart? (18980852)
2009
30
Interferon and cytokine responses to Crimean Congo hemorrhagic fever virus; an emerging and neglected viral zonoosis. (19027345)
2008
31
Clinical investigation of the transient evoked otoacoustic emission test in Crimean-Congo hemorrhagic fever. (17714968)
2008
32
Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever. (17806044)
2007
33
Cytokine levels in Crimean-Congo hemorrhagic fever. (16765637)
2006
34
Exogenous nitric oxide inhibits Crimean Congo hemorrhagic fever virus. (16632039)
2006
35
Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. (15953646)
2006
36
Measures undertaken in the German Armed Forces Field Hospital deployed in Kosovo to contain a potential outbreak of Crimean-Congo hemorrhagic fever. (15974201)
2005
37
Genetic analysis of Crimean-congo hemorrhagic fever virus in Iran. (15170636)
2004
38
Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy. (15307042)
2004
39
Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus. (15047845)
2004
40
Genetic characterization of the M RNA segment of Crimean-Congo hemorrhagic fever virus strains isolated in Russia and Tajikistan. (14976418)
2004
41
Crimean-Congo hemorrhagic fever in Sistan and Baluchestan Province of Iran, a case-control study on epidemiological characteristics. (15325599)
2004
42
Genetic analysis of Crimean-Congo hemorrhagic fever virus in Russia. (12574301)
2003
43
Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus. (11980926)
2002
44
Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. (12089242)
2002
45
Genetic detection and isolation of crimean-congo hemorrhagic fever virus, Kosovo, Yugoslavia. (12141973)
2002
46
Isolation of Crimean-Congo hemorrhagic fever virus from ticks on imported Sudanese sheep in Saudi Arabia. (17322717)
2000
47
Prevalence of sand fly fever, West Nile, Crimean-Congo hemorrhagic fever, and leptospirosis antibodies in Pakistani military personnel. (8637643)
1996
48
Preparation and use of monoclonal antibodies for identifying Crimean-Congo hemorrhagic fever virus. (3116871)
1987
49
Epidemiologic and clinical features of Crimean-Congo hemorrhagic fever in southern Africa. (3101525)
1987
50
Comparison of methods for isolation and titration of Crimean-Congo hemorrhagic fever virus. (3095367)
1986

Genetic Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 53Reactome, 52R&D Systems
See all sources

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3NFKB1
210.1NFKB1, CASP3
39.9IL6, NFKB1, CASP3
4
Hide members
9.8NFKB1, TNF, CASP3
5
Immune response Bacterial infections in normal airways
9.8TNF, NFKB1, IL6
69.8IL6, NFKB1, TNF
79.8TNF, NFKB1, IL6
89.8TNF, NFKB1, IL6
9
Hide members
9.8IL6, NFKB1, TNF
109.8TLR8, NFKB1, IL6
11
Hide members
9.8TLR8, TNF, IL6
12
Hide members
9.8TLR8, TNF, IL6
13
Hide members
9.7NFKB1, TNFRSF19, CASP3
14
Development PDGF signaling via STATs and NF-kB
Hide members
9.7F2, IL6, NFKB1, TNF
159.7TNF, NFKB1, IL6, F2
16
Hide members
9.6F3, IL6, NFKB1, TNF
179.6IL6, NFKB1, TNF, CASP3
18
Hide members
9.6CASP3, TNF, NFKB1, IL6
199.6CASP3, TNF, NFKB1, IL6
209.6CASP3, TNF, NFKB1, IL6
219.6IL6, NFKB1, TNF, CASP3
22
Hide members
9.6ISG20, NFKB1, IL6, MX1
239.6NFKB1, VEGFA, TNF, CASP3
24
Hide members
9.6TLR8, TNF, NFKB1, IL6
25
Hide members
9.5CASP3, TNF, NFKB1, IL6, MX1
269.4CASP3, TNF, VEGFA, NFKB1, IL6
279.4CASP3, TLR8, TNF, NFKB1, IL6
28
Hide members
9.4CASP3, TLR8, TNF, NFKB1, IL6
29
Hide members
9.2NFKB1, TNF, TNFRSF19, TLR8, CASP3

Compounds for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6MX1
2prednisolone44 28 1112.5SLC17A5
3aprotinin44 1111.5SLC17A5, F3
4pdtc4410.5IL6, F3
5aprosulate4410.4F3, F2
6napsagatran4410.4F3, F2
7brodifacoum4410.4F3, F2
8ximelagatran44 1111.4F3, GPT, F2
9troglitazone44 28 59 1113.3SLC17A5, GPT, CASP3
10aminopyrine4410.3GPT, F2, SLC17A5
11lamivudine44 1111.3F2, SLC17A5
12hemochron4410.3F3, F2
13gm-csf44 2811.3TNF
14d-galactosamine4410.3TNF, GPT, SLC17A5
15certoparin4410.3F3, F2
16appt4410.2F3, F2
17hepaplastin4410.2SLC17A5, F2, GPT, F3
18levonorgestrel44 59 28 1113.2F3, F2, SLC17A5
19nash4410.2TNF, CHIT1, GPT, SLC17A5
20tpck4410.2IL6, TNF, CASP3
21silymarin4410.1VEGFA, GPT, F2, SLC17A5
22cyclosporin a44 28 5912.1SLC17A5, F2, GPT, RNPC3
23pge14410.1IL6, GPT, F2, SLC17A5
24zoledronic acid4410.1CASP3, VEGFA, IL6
25ribavirin44 49 1112.1SLC17A5, MX1, GPT, ISG20
26fenofibrate44 49 1112.1TNF, IL6, GPT, SLC17A5
27protamine4410.0RNPC3, IL6, F3, F2
28imiquimod44 28 59 1113.0TLR8, TNF, IL6, MX1
29triptolide4410.0CASP3, TNF, VEGFA, IL6
30poly(i-c)4410.0MX1, IL6, TNF, TLR8
31aebsf4410.0F3, TNF, MBTPS1, CASP3
3215-deoxy-delta-12,14-prostaglandin j24410.0IL6, VEGFA, TNF, CASP3
33sp 60012544 5911.0CASP3, TNF, IL6, F3
34thalidomide44 49 59 1113.0TNF, VEGFA, NFKB1, IL6
35rosiglitazone44 49 28 11 2413.9SLC17A5, GPT, IL6, TNF
36pioglitazone44 49 28 1112.9TNF, VEGFA, IL6, GPT, SLC17A5
37methotrexate44 49 1111.9TNF, IL6, GPT, F2, SLC17A5
38atorvastatin44 49 28 11 2413.9TNF, VEGFA, IL6, GPT, SLC17A5
392,5-oligoadenylate449.9TNF, ISG20, IL6, GPT, MX1
40ciglitazone44 2810.8CASP3, TNF, IL6
41rosuvastatin44 49 28 1112.8IL6, GPT, SLC17A5
42neopterin449.8TNF, CHIT1, IL6, GPT, MX1, SLC17A5
43sb 20358044 5910.8CASP3, TNF, VEGFA, IL6, F3
44lactate449.7CASP3, TNF, IL6, GPT, F2, SLC17A5
45fibrinogen449.6TNF, CHIT1, IL6, F3, GPT, F2
46hyaluronic acid44 2410.5STAB2, VEGFA, IL6, GPT, F2, SLC17A5
47parthenolide44 210.5CASP3, TNF, IL6
48n acetylcysteine449.5CASP3, TNF, VEGFA, IL6, GPT, F2
49actinomycin d449.4F3, IL6, VEGFA, TNF, CASP3
50simvastatin44 49 59 28 11 2414.4SLC17A5, CASP3, TNF, VEGFA, IL6, F3

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
16Gene Ontology
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Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.3F2, F3, IL6, VEGFA, CHIT1, TNF

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.1IL6, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1IL6, TNF
3negative regulation of viral genome replicationGO:04507110.0TNF, ISG20, MX1
4positive regulation of peptidyl-serine phosphorylationGO:03313810.0TNF, VEGFA, IL6
5positive regulation of interleukin-8 biosynthetic processGO:0454169.9TNF, TLR8
6positive regulation of protein phosphorylationGO:0019349.8F2, VEGFA, TNF
7positive regulation of protein kinase B signaling cascadeGO:0518979.8TNF, IL6, F3
8positive regulation of positive chemotaxisGO:0509279.8F3, VEGFA
9response to virusGO:0096159.8MX1, ISG20, TNF, TLR8
10defense response to virusGO:0516079.7MX1, IL6, ISG20, TLR8
11regulation of cell shapeGO:0083609.7PARVA, F2, IL6, VEGFA

Products for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources for Crimean-Congo Hemorrhagic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet