CCHF
MCID: CRM001
MIFTS: 55

Crimean-Congo Hemorrhagic Fever (CCHF) malady

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 45NCIt, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 11 54 2 13
Hemorrhagic Fever, Crimean 39 68
Crimean Hemorrhagic Fever 11 54
Congo Hemorrhagic Fever 54 68
Cchf 54 2
 
Congo-Crimean Hemorrhagic Fever 11
Hemorrhagic Fever Crimean-Congo 50
Chf Congo Virus 11
Congo Fever 54

Characteristics:

Orphanet epidemiological data:

54
crimean-congo hemorrhagic fever:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:12287
ICD1030 A98.0
ICD9CM32 065.0
MeSH39 D006479
SNOMED-CT62 43489008
NCIt45 C34682
Orphanet54 ORPHA99827
ICD10 via Orphanet31 A98.0

Summaries for Crimean-Congo Hemorrhagic Fever

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Disease Ontology:11 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to hemorrhagic fever and rift valley fever, and has symptoms including Array, Array and Array. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways are Overview of nanoparticle effects and Cytokines and Inflammatory Response. Affiliated tissues include eye, skin and testes, and related mouse phenotypes are digestive/alimentary and integument.

CDC:2 Crimean-Congo hemorrhagic fever is found in Eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

Related Diseases for Crimean-Congo Hemorrhagic Fever

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Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever11.4
2rift valley fever10.4
3endotheliitis10.3
4vps11-related autosomal recessive hypomyelinating leukodystrophy10.2IL6, TNF
5dyslexia 510.2IL6, TNF
6aortic atherosclerosis10.2IL6, TNF
7unilateral multicystic dysplastic kidney10.2IL6, TNF
8thymic neuroendocrine carcinoma10.2IL6, TNF
9swine influenza10.2IL6, TNF
10drug dependence10.2IL6, TNF
11senile atrophy of choroid10.2CASP3, VEGFA
12transient tic disorder10.2IL6, TNF
13west nile virus10.2
14tick-borne encephalitis10.2
15encephalitis10.2
16anal paget's disease10.2IL6, TNF
17papilledema10.2IL6, TNF
18angiomatosis, diffuse corticomeningeal, of divry and van bogaert10.2IL6, TNF
19aortic coarctation10.1IL6, TNF
20preaxial polydactyly of fingers10.1IL6, TNF
21human immunodeficiency virus infectious disease10.1IL6, TNF
22craniosynostosis, type 110.1IL6, VEGFA
23secretory diarrhea myopathy and deafness10.1F3, IL6
24cardiac tuberculosis10.1IL6, VEGFA
25esophagus lymphoma10.1IL6, TNF
26immunoglobulin g deficiency10.1CASP3, IL6, TNF
27splenic marginal zone lymphoma10.1CASP3, IL6, TNF
28depressed scar10.1F3, IL6, TNF
29meningitis10.1CASP3, IL6, TNF
30membranoproliferative glomerulonephritis10.1F3, IL6, TNF
31tinea capitis10.1IL6, TNF
32uterine corpus cancer10.1CXCL10, F3, TNF
33prinzmetal's variant angina10.0CASP3, IL6, VEGFA
34tracheal calcification10.0GPT, TNF
35placenta praevia10.0CASP3, TNF, VEGFA
36degenerative disc disease10.0IL6, TNF, VEGFA
37vulvitis10.0F3, IL6, VEGFA
38conjugate gaze palsy10.0IL6, VEGFA
39bipolar i disorder10.0IL6, TNF, VEGFA
40leukoplakia of vagina10.0IL6, TNF, VEGFA
41ectodermal dysplasia bartalos type10.0IL6, TNF, VEGFA
42bladder signet ring cell adenocarcinoma10.0CXCL10, IL6, TNF
43choanal atresia, bilateral10.0CXCL10, IL6, TNF
44malaria10.0
45pulmonary hypertension10.0
46hemophagocytic lymphohistiocytosis10.0
47thrombocytopenia10.0
48parotitis10.0
49thrombotic thrombocytopenic purpura10.0
50hemorrhagic fever with renal syndrome10.0

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

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Symptoms:

 11 (show all 13)
  • headache
  • high fever
  • back pain
  • joint pain
  • stomach pain
  • vomiting
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • jaundice
  • nosebleeds
  • blood in the feces

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

 54 64 (show all 23)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 gingival bleeding64 54 Occasional (29-5%) HP:0000225
2 epistaxis64 54 Occasional (29-5%) HP:0000421
3 uveitis64 54 Frequent (79-30%) HP:0000554
4 jaundice64 54 Occasional (29-5%) HP:0000952
5 petechiae64 54 Frequent (79-30%) HP:0000967
6 skin rash64 54 Frequent (79-30%) HP:0000988
7 hepatic steatosis64 54 Frequent (79-30%) HP:0001397
8 thrombocytopenia64 54 Occasional (29-5%) HP:0001873
9 leukopenia64 54 Occasional (29-5%) HP:0001882
10 abnormal bleeding54 Occasional (29-5%)
11 fever64 54 Very frequent (99-80%) HP:0001945
12 diarrhea64 54 Frequent (79-30%) HP:0002014
13 nausea and vomiting64 54 Frequent (79-30%) HP:0002017
14 abdominal pain64 54 Frequent (79-30%) HP:0002027
15 gastrointestinal hemorrhage64 54 Occasional (29-5%) HP:0002239
16 headache64 54 Frequent (79-30%) HP:0002315
17 elevated hepatic transaminases64 54 Frequent (79-30%) HP:0002910
18 myalgia64 54 Frequent (79-30%) HP:0003326
19 cardiorespiratory arrest64 54 Occasional (29-5%) HP:0006543
20 fatigue64 54 Very frequent (99-80%) HP:0012378
21 cough64 54 Frequent (79-30%) HP:0012735
22 chest pain64 54 Occasional (29-5%) HP:0100749
23 recurrent pharyngitis64 54 Frequent (79-30%) HP:0100776

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9CASP3, IL6, NFKB1, TNF, VEGFA
2MP:00107718.5CASP3, F3, IL6, NFKB1, TNF, VEGFA
3MP:00053698.5CASP3, F3, IL6, NFKB1, TNF, VEGFA
4MP:00053848.1CASP3, CXCL10, F3, IL6, NFKB1, TNF
5MP:00036318.0CASP3, CXCL10, F3, IL6, NFKB1, TNF
6MP:00053887.7CASP3, F3, IL6, NFKB1, TNF, VEGFA
7MP:00053767.7CASP3, CXCL10, F3, IL6, NFKB1, TLR8
8MP:00053877.7CASP3, CXCL10, F3, IL6, NFKB1, TLR8
9MP:00053976.9CASP3, CXCL10, F3, GPT, IL6, NFKB1

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 2100336791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2AntimetabolitesPhase 212054
3Anti-Infective AgentsPhase 222062
4Antiviral AgentsPhase 29967
5
Formaldehydeapproved, vet_approvedPhase 19350-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalin
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
6VaccinesPhase 16611
7Pharmaceutical SolutionsPhase 18192

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for HumansActive, not recruitingNCT03020771Phase 1
3Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
4Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverEnrolling by invitationNCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever


Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

36
Eye, Skin, Testes, Endothelial, Heart, Neutrophil

Publications for Crimean-Congo Hemorrhagic Fever

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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran. (27308275)
2016
2
Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. (27353580)
2016
3
Does Crimean-Congo Hemorrhagic Fever Cause a Vasculitic Reaction with Pulmonary Artery Enlargement and Acute Pulmonary Hypertension? (27344326)
2016
4
The prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever. (27089100)
2016
5
Multi-center prospective evaluation of discharge criteria for hospitalized patients with Crimean-Congo Hemorrhagic Fever. (27424492)
2016
6
Crimean-Congo Hemorrhagic Fever Knowledge, Attitudes, Practices, Risk Factors, and Seroprevalence in Rural Georgian Villages with Known Transmission in 2014. (27336731)
2016
7
Crimean-Congo hemorrhagic fever among children in Iran. (27878461)
2016
8
A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus. (27713073)
2016
9
Relationship between IFNA1, IFNA5, IFNA10, and IFNA17 gene polymorphisms and Crimean-Congo hemorrhagic fever prognosis in a Turkish population range. (26694082)
2016
10
Determination of nasal mucociliary clearance time and nasal symptom in patients with crimean-congo hemorrhagic fever. (27813123)
2016
11
Crimean-Congo Hemorrhagic Fever in Dubai, United Arab Emirates, 2010: Case Report. (27795839)
2016
12
Phylogeography of Crimean Congo Hemorrhagic Fever Virus. (27880794)
2016
13
Biosafety standards for working with Crimean-Congo hemorrhagic fever virus. (27667586)
2016
14
PRESEPSIN LEVELS OF PATIENTS WITH CRIMEAN-CONGO HEMORRHAGIC FEVER. (27000451)
2016
15
Examination of the specific clinical symptoms and laboratory findings of Crimean-Congo hemorrhagic fever. (27353587)
2016
16
Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses. (27217069)
2016
17
Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. (27110812)
2016
18
A competitive ELISA for species-independent detection of Crimean-Congo hemorrhagic fever virus specific antibodies. (27623345)
2016
19
Crimean-Congo Hemorrhagic Fever with Acute Subdural Hematoma, Mauritania, 2012. (27315138)
2016
20
The prognostic significance of serum TGF-I^1 levels in patients with Crimean-Congo hemorrhagic fever. (27467498)
2016
21
A retrospective controlled study of thiol disulfide homeostasis as a novel marker in Crimean Congo hemorrhagic fever. (27159644)
2016
22
Molecular analysis of Crimean-Congo hemorrhagic fever virus and Rickettsia in Hyalomma marginatum ticks removed from patients (Spain) and birds (Spain and Morocco), 2009-2015. (27215620)
2016
23
Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana. (27392037)
2016
24
Protective role of host aquaporin 6 against Hazara virus, a model for Crimean-Congo hemorrhagic fever virus infection. (26976854)
2016
25
Phylogeny of tick-derived Crimean-Congo hemorrhagic fever virus strains in Iran. (27491289)
2016
26
Possible sexual transmission of Crimean-Congo hemorrhagic fever. (26972040)
2016
27
Molecular Assay on Crimean Congo Hemorrhagic Fever Virus in Ticks (Ixodidae) Collected from Kermanshah Province, Western Iran. (27308296)
2016
28
Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity. (27775001)
2016
29
Seroprevalence of Crimean-Congo hemorrhagic fever in Turkey's Van Province. (27169950)
2016
30
MicroRNA expression profiles in patients with acute Crimean Congo Hemorrhagic Fever reveal possible adjustments to cellular pathways. (27551771)
2016
31
A child with an unusual complication of Crimean-Congo hemorrhagic fever: Hemorrhagic pleural effusion. (27004585)
2016
32
Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. (27666016)
2016
33
Thorax CT findings in patients with Crimean-Congo hemorrhagic fever (CCHF). (27818861)
2016
34
Crimean-Congo hemorrhagic fever virus lineages Europe 1 and Europe 2 in Bulgarian ticks. (27378409)
2016
35
Novel, In-House, SYBR Green Based One-Step rRT-PCR: Rapid and Accurate Diagnosis of Crimean-Congo Hemorrhagic Fever Virus in Suspected Patients From Iran. (27099688)
2016
36
Clinical severity in forecasting platelet to lymphocyte ratio in Crimean-Congo hemorrhagic fever patients. (27501696)
2016
37
Epidemiological Survey of Crimean-Congo Hemorrhagic Fever (CCHF), a Fatal Infectious Disease in Khuzestan Province, Southwest Iran, During 1999 - 2015. (27540454)
2016
38
Heat Shock Protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle. (27512070)
2016
39
Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever. (27378224)
2016
40
Serum sTREM-1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection. (26877157)
2016
41
Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system. (26935918)
2016
42
The first fatal case of Crimean-Congo Hemorrhagic Fever due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus. (26902209)
2016
43
Molecular epidemiology of Crimean-Congo hemorrhagic fever virus detected from ticks of one humped camels (Camelus dromedarius) population in northeastern Iran. (27065608)
2016
44
Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area. (27677379)
2016
45
Crimean-Congo Hemorrhagic Fever Virus in Bulgaria and Turkey. (27467142)
2016
46
Crimean-Congo hemorrhagic fever - A ticking bomb? (27044612)
2016
47
Crimean-Congo hemorrhagic fever with hyperbilirubinemia and ascites: An unusual presentation. (26129885)
2016
48
Sero-epidemiological survey of Crimean-Congo hemorrhagic fever virus in Tunisia. (26956221)
2016
49
Crimean Congo Hemorrhagic Fever Virus and Alkhurma (Alkhumra) Virus in Ticks in Djibouti. (27508862)
2016
50
Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran. (27047968)
2016

Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL6, TNF
29.7IL6, TNF
39.7IL6, TNF
49.7IL6, TNF
59.7IL6, TNF
69.6NFKB1, TNF
79.6NFKB1, TNF
89.5IL6, NFKB1
99.5CASP3, TNF
109.4NFKB1, VEGFA
11
Show member pathways
9.3IL6, TLR8, TNF
129.3CXCL10, IL6, TNF
139.3CXCL10, IL6, TNF
14
Show member pathways
9.2IL6, NFKB1, TNF
159.2IL6, NFKB1, TNF
16
Show member pathways
9.2IL6, NFKB1, TNF
17
Show member pathways
9.2IL6, NFKB1, TNF
189.2IL6, NFKB1, TNF
199.2IL6, NFKB1, TNF
209.2IL6, NFKB1, TNF
219.2IL6, TNF, VEGFA
229.2IL6, TNF, VEGFA
239.1NFKB1, TNF, VEGFA
249.1NFKB1, TNF, VEGFA
259.0IL6, NFKB1, VEGFA
26
Show member pathways
9.0CASP3, NFKB1, TNF
27
Show member pathways
9.0CASP3, NFKB1, TNF
28
Show member pathways
9.0CASP3, NFKB1, TNF
299.0CASP3, TNF, VEGFA
308.9CASP3, IL6, NFKB1
31
Show member pathways
8.8IL6, NFKB1, TLR8, TNF
32
Show member pathways
8.8IL6, NFKB1, TLR8, TNF
33
Show member pathways
8.8CASP3, NFKB1, VEGFA
348.8CASP3, NFKB1, VEGFA
358.8CXCL10, NFKB1, TLR8, TNF
36
Show member pathways
8.7CXCL10, IL6, NFKB1, TNF
37
Show member pathways
8.7IL6, NFKB1, TNF, VEGFA
388.6CASP3, CXCL10, IL6, TNF
398.6CASP3, IL6, NFKB1, TNF
408.6CASP3, IL6, NFKB1, TNF
41
Show member pathways
8.6CASP3, IL6, NFKB1, TNF
428.6CASP3, IL6, NFKB1, TNF
438.6CASP3, IL6, NFKB1, TNF
44
Show member pathways
8.6CASP3, IL6, TNF, VEGFA
45
Show member pathways
8.5F3, IL6, NFKB1, TLR8, TNF
468.4CASP3, IL6, NFKB1, VEGFA
478.4CASP3, IL6, NFKB1, VEGFA
48
Show member pathways
8.4CXCL10, IL6, NFKB1, TLR8, TNF
498.1CASP3, CXCL10, IL6, NFKB1, TNF
50
Show member pathways
8.1CASP3, CXCL10, IL6, NFKB1, TNF

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.7CXCL10, IL6, TLR8, TNF
2extracellular regionGO:00055768.6CXCL10, F3, IL6, NFKB1, TNF, VEGFA
3extracellular spaceGO:00056157.6CXCL10, F3, GPT, IL6, TNF, VEGFA

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:004541610.5TLR8, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.5IL6, TNF
3negative regulation of lipid storageGO:001088810.5IL6, TNF
4positive regulation of chemokine productionGO:003272210.5IL6, TNF
5negative regulation of myoblast differentiationGO:004566210.4CXCL10, TNF
6cellular response to nicotineGO:007131610.4NFKB1, TNF
7positive regulation of positive chemotaxisGO:005092710.4F3, VEGFA
8positive regulation of protein complex assemblyGO:003133410.3TNF, VEGFA
9response to auditory stimulusGO:001099610.2CXCL10, IL6
10positive regulation of protein kinase B signalingGO:005189710.1F3, IL6, TNF
11response to antibioticGO:004667710.1CASP3, IL6
12defense response to virusGO:005160710.0CXCL10, IL6, TLR8
13I-kappaB kinase/NF-kappaB signalingGO:000724910.0NFKB1, TLR8, TNF
14activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.0CASP3, F3, TNF
15positive regulation of NF-kappaB transcription factor activityGO:00510929.9IL6, NFKB1, TNF
16positive regulation of peptidyl-serine phosphorylationGO:00331389.9IL6, TNF, VEGFA
17positive regulation of cell migrationGO:00303359.9CXCL10, F3, VEGFA
18regulation of cell proliferationGO:00421279.9CXCL10, IL6, TNF
19response to glucocorticoidGO:00513849.7CASP3, IL6, TNF
20response to lipopolysaccharideGO:00324969.5CASP3, CXCL10, IL6
21cellular response to lipopolysaccharideGO:00712229.5CXCL10, IL6, NFKB1, TNF
22response to virusGO:00096159.3CXCL10, TLR8, TNF
23negative regulation of apoptotic processGO:00430669.1CASP3, IL6, NFKB1, VEGFA
24inflammatory responseGO:00069549.1CXCL10, IL6, NFKB1, TLR8, TNF
25positive regulation of transcription from RNA polymerase II promoterGO:00459448.9CXCL10, IL6, NFKB1, TNF, VEGFA

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.3CXCL10, IL6, TNF, VEGFA
2protease bindingGO:00020209.2CASP3, F3, TNF

Sources for Crimean-Congo Hemorrhagic Fever

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet