MCID: CRM001
MIFTS: 55

Crimean-Congo Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

MalaCards integrated aliases for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 12 56 3 14
Hemorrhagic Fever, Crimean 42 69
Congo Hemorrhagic Fever 56 69
Cchf 56 3
Crimean Hemorrhagic Fever [chf Congo Virus] 12
Congo-Crimean Hemorrhagic Fever 12
Hemorrhagic Fever Crimean-Congo 52
Crimean Hemorrhagic Fever 56
Chf Congo Virus 12
Congo Fever 56

Characteristics:

Orphanet epidemiological data:

56
crimean-congo hemorrhagic fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


Summaries for Crimean-Congo Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary : Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to hemophagocytic lymphohistiocytosis and malaria, and has symptoms including diarrhea, headache and jaundice. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes, and related phenotypes are hematopoietic system and cellular

CDC : 3 Crimean-Congo hemorrhagic fever is found in Eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

Related Diseases for Crimean-Congo Hemorrhagic Fever

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
id Related Disease Score Top Affiliating Genes
1 hemophagocytic lymphohistiocytosis 30.3 IL6 TNF
2 malaria 28.3 CASP3 CXCL10 F3 IL6 TNF
3 hemorrhagic fever 11.4
4 tetanus 10.5 PIK3C2A TNF
5 rete ovarii adenoma 10.5 PIK3C2A TNF
6 megaloblastic anemia 10.5 F3 TNF
7 virilizing ovarian tumor 10.4 IL6 PIK3C2A
8 rift valley fever 10.4
9 chronic diarrhea due to guanylate cyclase 2c overactivity 10.4 F3 IL6
10 primary malignant melanoma of the conjunctiva 10.3 CASP3 IL6
11 dementia pugilistica 10.3 IL6 PIK3C2A
12 autosomal dominant polycystic kidney disease 10.3 CASP3 IL6
13 smarca4-deficient sarcoma of thorax 10.3 IL6 TNF
14 aortic arch interruption 10.3 IL6 TNF
15 cutaneous leishmaniasis 10.3 IL6 TNF
16 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.3 F3 IL6
17 spirillary rat-bite fever 10.3 IL6 TNF
18 toxoplasmosis 10.3 IL6 TNF
19 dyslexia 5 10.3 IL6 TNF
20 scrotal carcinoma 10.3 IL6 TNF
21 anencephaly and spina bifida x-linked 10.3 IL6 TNF
22 antigen-peptide-transporter 2 deficiency 10.3 IL6 TNF
23 papilledema 10.3 IL6 TNF
24 ethmoid sinus adenocarcinoma 10.3 IL6 TNF
25 upper gum cancer 10.3 IL6 TNF
26 potato nose 10.3 IL6 TNF
27 bipolar i disorder 10.3 IL6 TNF
28 lymphocytic colitis 10.3 IL6 TNF
29 pasteurellosis 10.3 IL6 TNF
30 tinea favosa 10.3 IL6 TNF
31 central nervous system leiomyosarcoma 10.3 IL6 TNF
32 indolent myeloma 10.3 IL6 TNF
33 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.3 IL6 TNF
34 cicatricial lagophthalmos 10.3 IL6 TNF
35 endotheliitis 10.3
36 tricho onychic dysplasia 10.2 IL6 TNF
37 phlyctenulosis 10.2 IL6 TNF
38 islet cell tumor 10.2 IL6 TNF
39 cyclosporiasis 10.2 IL6 TNF
40 hypogonadotropism 10.2 IL6 TNF
41 early-onset zonular cataract 10.2 IL6 TNF
42 anogenital venereal wart 10.2 F3 PIK3C2A TNF
43 primary biliary cirrhosis 10.2 IL6 TNF
44 placental abruption 10.2 IL6 TNF
45 tracheal stenosis 10.2 IL6 TNF
46 acquired thrombocytopenia 10.2 IL6 TNF
47 ampulla of vater neoplasm 10.2 IL6 TNF
48 benign neonatal seizures 10.2 IL6 TNF
49 tick-borne encephalitis 10.2
50 encephalitis 10.2

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to Crimean-Congo Hemorrhagic Fever

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

56 32 (show all 23)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 diarrhea 56 32 frequent (33%) Frequent (79-30%) HP:0002014
2 headache 56 32 frequent (33%) Frequent (79-30%) HP:0002315
3 jaundice 56 32 occasional (7.5%) Occasional (29-5%) HP:0000952
4 thrombocytopenia 56 32 occasional (7.5%) Occasional (29-5%) HP:0001873
5 leukopenia 56 32 occasional (7.5%) Occasional (29-5%) HP:0001882
6 fatigue 56 32 hallmark (90%) Very frequent (99-80%) HP:0012378
7 myalgia 56 32 frequent (33%) Frequent (79-30%) HP:0003326
8 epistaxis 56 32 occasional (7.5%) Occasional (29-5%) HP:0000421
9 petechiae 56 32 frequent (33%) Frequent (79-30%) HP:0000967
10 fever 56 32 hallmark (90%) Very frequent (99-80%) HP:0001945
11 hepatic steatosis 56 32 frequent (33%) Frequent (79-30%) HP:0001397
12 abdominal pain 56 32 frequent (33%) Frequent (79-30%) HP:0002027
13 cough 56 32 frequent (33%) Frequent (79-30%) HP:0012735
14 skin rash 56 32 frequent (33%) Frequent (79-30%) HP:0000988
15 chest pain 56 32 occasional (7.5%) Occasional (29-5%) HP:0100749
16 gingival bleeding 56 32 occasional (7.5%) Occasional (29-5%) HP:0000225
17 uveitis 56 32 frequent (33%) Frequent (79-30%) HP:0000554
18 elevated hepatic transaminases 56 32 frequent (33%) Frequent (79-30%) HP:0002910
19 gastrointestinal hemorrhage 56 32 occasional (7.5%) Occasional (29-5%) HP:0002239
20 nausea and vomiting 56 32 frequent (33%) Frequent (79-30%) HP:0002017
21 recurrent pharyngitis 56 32 frequent (33%) Frequent (79-30%) HP:0100776
22 cardiorespiratory arrest 56 32 occasional (7.5%) Occasional (29-5%) HP:0006543
23 abnormal bleeding 56 Occasional (29-5%)

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CASP3 CXCL10 F3 IL6 NFKB1 PIK3C2A
2 cellular MP:0005384 9.95 CASP3 CXCL10 F3 IL6 NFKB1 PIK3C2A
3 homeostasis/metabolism MP:0005376 9.92 IL6 NFKB1 PIK3C2A TLR8 TNF CASP3
4 immune system MP:0005387 9.86 CASP3 CXCL10 F3 IL6 NFKB1 PIK3C2A
5 muscle MP:0005369 9.55 CASP3 F3 IL6 NFKB1 TNF
6 nervous system MP:0003631 9.5 CASP3 CXCL10 F3 IL6 NFKB1 PIK3C2A
7 respiratory system MP:0005388 9.02 CASP3 F3 IL6 NFKB1 TNF

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2 Anti-Infective Agents Phase 2
3 Antimetabolites Phase 2
4 Antiviral Agents Phase 2
5
Formaldehyde Approved, Vet_approved Phase 1 50-00-0 712
6 Pharmaceutical Solutions Phase 1
7 Vaccines Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2 Ribavirin (Virazole) Injection
2 Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans Active, not recruiting NCT03020771 Phase 1
3 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
4 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260 Ribavirin

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

39
Eye, Skin, Testes, Endothelial, Heart, Neutrophil

Publications for Crimean-Congo Hemorrhagic Fever

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 520)
id Title Authors Year
1
Generic amplification and next generation sequencing reveal Crimean-Congo hemorrhagic fever virus AP92-like strain and distinct tick phleboviruses in Anatolia, Turkey. ( 28705183 )
2017
2
Crimean-Congo hemorrhagic fever virus nucleocapsid protein has dual RNA binding modes. ( 28922369 )
2017
3
Serosurvey for Crimean-Congo hemorrhagic fever virus infections in ruminants in Katanga province, Democratic Republic of the Congo. ( 28712556 )
2017
4
Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks. ( 28736753 )
2017
5
A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models. ( 28922426 )
2017
6
Effect of TLR10 (2322A/G, 720A/C, and 992T/A) polymorphisms on the pathogenesis of Crimean Congo hemorrhagic fever disease. ( 28843003 )
2017
7
Molecular detection of Crimean-Congo hemorrhagic fever virus in ticks, Greece, 2012-2014. ( 28920177 )
2017
8
Serosurvey of Crimean-Congo Hemorrhagic Fever Virus in Cattle, Mali, West Africa. ( 28719259 )
2017
9
Tetracyclines as a potential antiviral therapy against Crimean Congo hemorrhagic fever virus: Docking and molecular dynamic studies. ( 28709136 )
2017
10
A neonatal death associated with Crimean-Congo hemorrhagic fever (Republic of Kalmykia, Russia, June 2016). ( 28870741 )
2017
11
Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014. ( 28836897 )
2017
12
Crimean-Congo hemorrhagic fever virus in ticks collected from livestock in Albania. ( 28827176 )
2017
13
Seroepidemiology and risk factors of Crimean-Congo Hemorrhagic Fever among butchers and slaughterhouse workers in southeastern Iran. ( 28935247 )
2017
14
Infection prevention and control practice for Crimean-Congo hemorrhagic fever-A multi-center cross-sectional survey in Eurasia. ( 28886039 )
2017
15
Space-time epidemiology of Crimean-Congo hemorrhagic fever (CCHF) in Iran. ( 28943247 )
2017
16
Identification of broadly neutralizing monoclonal antibodies against Crimean-Congo hemorrhagic fever virus. ( 28842265 )
2017
17
Crimean Congo hemorrhagic fever among the one-humped camel (Camelus dromedaries) in Central Sudan. ( 28774342 )
2017
18
Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease. ( 28877473 )
2017
19
Crimean-Congo Hemorrhagic Fever in Spain - New Arrival or Silent Resident? ( 28700846 )
2017
20
Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana. ( 27392037 )
2016
21
Crimean Congo Hemorrhagic Fever: A Looming Threat. ( 28712208 )
2016
22
Clinical severity in forecasting platelet to lymphocyte ratio in Crimean-Congo hemorrhagic fever patients. ( 27501696 )
2016
23
Thorax CT findings in patients with Crimean-Congo hemorrhagic fever (CCHF). ( 27818861 )
2016
24
Sero-epidemiological survey of Crimean-Congo hemorrhagic fever virus in Tunisia. ( 26956221 )
2016
25
Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area. ( 27677379 )
2016
26
MicroRNA expression profiles in patients with acute Crimean Congo Hemorrhagic Fever reveal possible adjustments to cellular pathways. ( 27551771 )
2016
27
A retrospective controlled study of thiol disulfide homeostasis as a novel marker in Crimean Congo hemorrhagic fever. ( 27159644 )
2016
28
Crimean-Congo Hemorrhagic Fever with Acute Subdural Hematoma, Mauritania, 2012. ( 27315138 )
2016
29
Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran. ( 27047968 )
2016
30
Relationship between IFNA1, IFNA5, IFNA10, and IFNA17 gene polymorphisms and Crimean-Congo hemorrhagic fever prognosis in a Turkish population range. ( 26694082 )
2016
31
Phylogeography of Crimean Congo Hemorrhagic Fever Virus. ( 27880794 )
2016
32
Molecular Assay on Crimean Congo Hemorrhagic Fever Virus in Ticks (Ixodidae) Collected from Kermanshah Province, Western Iran. ( 27308296 )
2016
33
Is there any relationship between Toll-like receptor 3 c.1377C/T and -7C/A polymorphisms and susceptibility to Crimean Congo hemorrhagic fever? ( 26959380 )
2016
34
Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever. ( 27378224 )
2016
35
Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. ( 27353580 )
2016
36
Multi-center prospective evaluation of discharge criteria for hospitalized patients with Crimean-Congo Hemorrhagic Fever. ( 27424492 )
2016
37
Molecular analysis of Crimean-Congo hemorrhagic fever virus and Rickettsia in Hyalomma marginatum ticks removed from patients (Spain) and birds (Spain and Morocco), 2009-2015. ( 27215620 )
2016
38
Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses. ( 27217069 )
2016
39
Crimean Congo Hemorrhagic Fever Virus and Alkhurma (Alkhumra) Virus in Ticks in Djibouti. ( 27508862 )
2016
40
Heat Shock Protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle. ( 27512070 )
2016
41
Current situation of Crimean-Congo hemorrhagic fever in Southeastern Europe and neighboring countries: a public health risk for the European Union? ( 27044611 )
2016
42
Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran. ( 27308275 )
2016
43
A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus. ( 27713073 )
2016
44
The first fatal case of Crimean-Congo Hemorrhagic Fever due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus. ( 26902209 )
2016
45
Crimean-Congo Hemorrhagic Fever in Dubai, United Arab Emirates, 2010: Case Report. ( 27795839 )
2016
46
Examination of the specific clinical symptoms and laboratory findings of Crimean-Congo hemorrhagic fever. ( 27353587 )
2016
47
A child with an unusual complication of Crimean-Congo hemorrhagic fever: Hemorrhagic pleural effusion. ( 27004585 )
2016
48
Crimean-Congo hemorrhagic fever - A ticking bomb? ( 27044612 )
2016
49
Protective role of host aquaporin 6 against Hazara virus, a model for Crimean-Congo hemorrhagic fever virus infection. ( 26976854 )
2016
50
A competitive ELISA for species-independent detection of Crimean-Congo hemorrhagic fever virus specific antibodies. ( 27623345 )
2016

Variations for Crimean-Congo Hemorrhagic Fever

Expression for Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for Crimean-Congo Hemorrhagic Fever

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 CASP3 CXCL10 IFNA17 IL6 NFKB1 TNF
2
Show member pathways
13.26 CASP3 CXCL10 IL6 NFKB1 TLR8 TNF
3
Show member pathways
13.21 CASP3 CXCL10 IFNA17 IL6 NFKB1 TNF
4
Show member pathways
13.15 CASP3 CXCL10 IL6 NFKB1 TNF
5
Show member pathways
12.82 F3 IFNA17 IL6 NFKB1 TLR8 TNF
6
Show member pathways
12.76 CASP3 IL6 NFKB1 TNF
7
Show member pathways
12.72 CASP3 IFNA17 IL6 TNF
8
Show member pathways
12.66 CXCL10 IFNA17 IL6 NFKB1 TLR8 TNF
9
Show member pathways
12.6 CASP3 CXCL10 IFNA17 IL6 NFKB1 TNF
10
Show member pathways
12.59 CXCL10 IFNA17 IL6 NFKB1 TNF
11
Show member pathways
12.57 IL6 NFKB1 TLR8 TNF
12 12.56 CASP3 IFNA17 IL6 NFKB1 TNF
13
Show member pathways
12.5 CASP3 NFKB1 TLR8 TNF
14 12.43 CXCL10 NFKB1 TLR8 TNF
15
Show member pathways
12.2 IFNA17 IL6 NFKB1
16
Show member pathways
12.19 CASP3 CXCL10 IL6 NFKB1 TNF
17
Show member pathways
12.16 IL6 NFKB1 TNF
18
Show member pathways
12.15 CASP3 NFKB1 TNF
19 12.08 CASP3 IL6 NFKB1 TNF
20
Show member pathways
12.05 IFNA17 IL6 TNF
21
Show member pathways
12.02 CASP3 NFKB1 TNF
22 11.97 CASP3 IFNA17 IL6 NFKB1 TNF
23 11.96 IFNA17 NFKB1 TNF
24
Show member pathways
11.93 NFKB1 PIK3C2A TLR8
25
Show member pathways
11.92 CASP3 NFKB1 TNF
26 11.9 CASP3 CXCL10 IL6 TNF
27
Show member pathways
11.87 CXCL10 IL6 NFKB1 TLR8 TNF
28
Show member pathways
11.86 IL6 NFKB1 TNF
29
Show member pathways
11.85 IL6 TLR8 TNF
30 11.78 CASP3 IL6 NFKB1 TNF
31 11.77 CASP3 IL6 NFKB1 TLR8 TNF
32 11.66 CASP3 IL6 NFKB1 TNF
33 11.64 IL6 NFKB1 TNF
34 11.6 CASP3 IL6 NFKB1
35
Show member pathways
11.58 IL6 NFKB1 TNF
36 11.48 CASP3 IL6 NFKB1
37 11.46 CXCL10 IL6 TNF
38 11.44 IL6 NFKB1 TNF
39 11.41 CASP3 IL6 NFKB1 TNF
40 11.39 CASP3 CXCL10 IL6 NFKB1 TNF
41 11.38 CASP3 IFNA17 IL6
42 11.28 IL6 NFKB1 TNF
43 11.26 IL6 TNF
44 11.23 IL6 NFKB1
45 11.22 CASP3 TNF
46 11.21 IL6 TNF
47 11.2 IL6 NFKB1 TNF
48 11.18 IL6 TNF
49 11.11 CXCL10 IL6 TNF
50 11.08 NFKB1 TNF

GO Terms for Crimean-Congo Hemorrhagic Fever

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CXCL10 F3 IFNA17 IL6 NFKB1 TNF
2 external side of plasma membrane GO:0009897 8.92 CXCL10 IL6 TLR8 TNF

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.79 CXCL10 IL6 TNF
2 response to lipopolysaccharide GO:0032496 9.77 CASP3 CXCL10 IL6
3 cytokine-mediated signaling pathway GO:0019221 9.75 F3 IFNA17 IL6
4 defense response GO:0006952 9.73 CXCL10 IFNA17 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 IL6 NFKB1 TNF
6 positive regulation of protein kinase B signaling GO:0051897 9.7 F3 IL6 TNF
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.63 CASP3 F3 TNF
8 response to antibiotic GO:0046677 9.61 CASP3 IL6
9 response to amino acid GO:0043200 9.6 CASP3 IL6
10 negative regulation of myoblast differentiation GO:0045662 9.58 CXCL10 TNF
11 response to glucocorticoid GO:0051384 9.58 CASP3 IL6 TNF
12 positive regulation of chemokine production GO:0032722 9.57 IL6 TNF
13 defense response to virus GO:0051607 9.56 CXCL10 IFNA17 IL6 TLR8
14 inflammatory response GO:0006954 9.55 CXCL10 IL6 NFKB1 TLR8 TNF
15 response to auditory stimulus GO:0010996 9.54 CXCL10 IL6
16 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.54 NFKB1 TLR8 TNF
17 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
18 humoral immune response GO:0006959 9.5 IFNA17 IL6 TNF
19 cellular response to nicotine GO:0071316 9.49 NFKB1 TNF
20 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.48 TLR8 TNF
21 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.43 IL6 TNF
22 cellular response to lipopolysaccharide GO:0071222 9.26 CXCL10 IL6 NFKB1 TNF
23 response to virus GO:0009615 8.92 CXCL10 IFNA17 TLR8 TNF

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 CASP3 F3 TNF
2 cytokine activity GO:0005125 8.92 CXCL10 IFNA17 IL6 TNF

Sources for Crimean-Congo Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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