Crimean-Congo Hemorrhagic Fever disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

Sources:
¹⁰Disease Ontology, ¹²DISEASES, ⁵¹Orphanet, ²CDC, ⁴⁷Novoseek, ⁶⁵UMLS, ³⁶MeSH, ²⁷ICD10, ²⁹ICD9CM, ⁴²NCIt, ⁵⁹SNOMED-CT, ²⁸ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever ¹⁰ ¹² ⁵¹ ²

Hemorrhagic Fever, Crimean ³⁶ ⁶⁵

Crimean Hemorrhagic Fever ¹⁰ ⁵¹

Congo Hemorrhagic Fever ⁵¹ ⁶⁵

Cchf ⁵¹ ²

Congo-Crimean Hemorrhagic Fever ¹⁰

Hemorrhagic Fever Crimean-Congo ⁴⁷

Chf Congo Virus ¹⁰

Congo Fever ⁵¹

Characteristics:

Orphanet epidemiological data:

⁵¹

crimean-congo hemorrhagic fever:
Age of onset: All ages; Age of death: any age

Classifications:

MalaCards categories:
Global: Genetic diseases, Infectious diseases, Rare diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ²⁸ ²⁷

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Other viral haemorrhagic fevers, not elsewhere classified

Crimean-Congo haemorrhagic fever

Orphanet: ⁵¹

Rare infectious diseases

External Ids:

Disease Ontology¹⁰ DOID:12287

ICD10²⁷ A98.0

ICD9CM²⁹ 065.0

MeSH³⁶ D006479

SNOMED-CT⁵⁹ 43489008

NCIt⁴² C34682

Orphanet⁵¹ 99827

ICD10 via Orphanet²⁸ A98.0

UMLS⁶⁵ C0019099, C1304456

Summaries for Crimean-Congo Hemorrhagic Fever

Sources:
¹⁰Disease Ontology, ³³MalaCards
See all MalaCards sources

Disease Ontology:¹⁰ A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to leptospirosis and malaria, and has symptoms including abnormality of temperature regulation, skin rash and hepatic steatosis. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways are Cytokines and Inflammatory Response and EBV LMP1 signaling. Affiliated tissues include eye, heart and t cells, and related mouse phenotypes are respiratory system and renal/urinary system.

Related Diseases for Crimean-Congo Hemorrhagic Fever

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
See all MalaCards sources

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)

id	Related Disease	Score	Top Affiliating Genes
1	leptospirosis	29.6	IL6, TNF, VEGFA
2	malaria	28.3	F3, IL6, TLR9, TNF, VEGFA
3	hemorrhagic fever	11.5
4	hydronephrosis	10.5	CASP3, TNF
5	rift valley fever	10.5
6	congenital dyserythropoietic anemia	10.4	IL6, MX1
7	endotheliitis	10.4
8	congenital chloride diarrhea	10.4	F3, IL6
9	plantar nerve lesion	10.4	IL6, TNF
10	intermediate dend syndrome	10.3	IL6, TNF
11	crohn's disease	10.3	IL6, TNF
12	malignant sertoli-leydig cell tumor of ovary	10.3	IL6, TNF
13	mammary paget's disease	10.3	IL6, TNF
14	lujo hemorrhagic fever	10.3	IL6, TNF
15	posterior valve urethra	10.3	IL6, TNF
16	t cell immunodeficiency primary	10.3	IL6, TNF
17	heterophyiasis	10.3	F3, IL6
18	parovarian cyst	10.3	IL6, TNF
19	precursor b lymphoblastic lymphoma/leukemia	10.3	IL6, TNF
20	collagenous colitis	10.3	IL6, TNF
21	early-onset, autosomal dominant alzheimer disease	10.3	IL6, TNF
22	tick-borne encephalitis	10.3
23	encephalitis	10.3
24	skin conditions	10.3	IL6, TNF
25	tick-borne relapsing fever	10.3	IL6, TNF
26	postsurgical hypothyroidism	10.3	IL6, TNF
27	streptococcal meningitis	10.3	IL6, TNF
28	dancing eyes-dancing feet syndrome	10.3	IL6, TNF
29	brain ischemia	10.3	CASP3, IL6
30	hemolytic anemia	10.3	IL6, TNF
31	diffuse intraductal papillomatosis	10.3	IL6, TNF
32	rubeosis iridis	10.3	IL6, TNF
33	ureteral disease	10.3	IL6, TNF
34	duodenum cancer	10.2	IL6, TNF
35	dentin caries	10.2	IL6, TNF
36	placental abruption	10.2	IL6, TNF
37	secretory diarrhea	10.2	IL6, TNF
38	meige syndrome	10.2	IL6, TNF
39	hypopharynx cancer	10.2	IL6, TNF
40	west nile virus	10.2
41	hemophagocytic lymphohistiocytosis	10.2
42	thrombocytopenia	10.2
43	parotitis	10.2
44	thrombotic thrombocytopenic purpura	10.2
45	hemorrhagic fever with renal syndrome	10.2
46	cholecystitis	10.2
47	post-traumatic stress disorder	10.2
48	acalculous cholecystitis	10.2
49	acute pancreatitis	10.2
50	ischemia	10.2

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:

Symptoms for Crimean-Congo Hemorrhagic Fever

Sources:
⁶¹The Human Phenotype Ontology, ⁵¹Orphanet, ¹⁰Disease Ontology, ⁶⁵UMLS
See all MalaCards sources

Symptoms:

⁵¹ ¹⁰ (show all 37)

fever/chilling
asthenia/fatigue/weakness
chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
cutaneous rash
purpura/petichiae
pharyngitis
nausea/vomiting/regurgitation/merycism/hyperemesis
acute abdominal pain/colic
acute diarrhea
liver/hepatic steatosis
abnormal hepatic enzymes/transaminases
cough
facial pain/cephalalgia/migraine
myalgia/muscular pain
gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
hepatitis/icterus/cholestasis
thoracic/chest pain
collapse/sudden death/cardiac arrest/cardiorespiratory arrest
leukopenia/hypoleukocytosis

thrombocytopenia/thrombopenia
hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
epistaxis/nose bleeding
gingivorrhagia/gingival bleeding
early death/lethality
headache
high fever
back pain
joint pain
stomach pain
vomiting
red eyes
flushed face
red throat
petechiae (red spots) on the palate
jaundice
nosebleeds
blood in the feces

HPO human phenotypes related to Crimean-Congo Hemorrhagic Fever:

(show all 20)

id	Description	Frequency	HPO Source Accession
1	abnormality of temperature regulation	hallmark (90%)	HP:0004370
2	skin rash	typical (50%)	HP:0000988
3	hepatic steatosis	typical (50%)	HP:0001397
4	subcutaneous hemorrhage	typical (50%)	HP:0001933
5	diarrhea	typical (50%)	HP:0002014
6	nausea and vomiting	typical (50%)	HP:0002017
7	abdominal pain	typical (50%)	HP:0002027
8	migraine	typical (50%)	HP:0002076
9	elevated hepatic transaminases	typical (50%)	HP:0002910
10	myalgia	typical (50%)	HP:0003326
11	inflammatory abnormality of the eye	typical (50%)	HP:0100533
12	recurrent pharyngitis	typical (50%)	HP:0100776
13	gingival bleeding	occasional (7.5%)	HP:0000225
14	epistaxis	occasional (7.5%)	HP:0000421
15	sudden cardiac death	occasional (7.5%)	HP:0001645
16	thrombocytopenia	occasional (7.5%)	HP:0001873
17	leukopenia	occasional (7.5%)	HP:0001882
18	abnormality of coagulation	occasional (7.5%)	HP:0001928
19	gastrointestinal hemorrhage	occasional (7.5%)	HP:0002239
20	chest pain	occasional (7.5%)	HP:0100749

UMLS symptoms related to Crimean-Congo Hemorrhagic Fever:

nail bed hemorrhage, mucosal haemorrhage, traumatic hematuria, cullen's sign, hemoptysis

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶Cochrane Library, ⁶⁵UMLS, ⁴³NDF-RT, ¹³DrugBank, ²⁶HMDB, ⁹DGIdb, ⁵³PharmGKB, ³⁰IUPHAR, ⁴⁷Novoseek, ¹BitterDB
See all MalaCards sources

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Ribavirin

approved

Phase 2

948

36791-04-5

37542

Synonyms:

1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide

36791-04-5

437710-49-1

66510-90-5

AA-504/07617051

AB00430481

AC1L1XXZ

AC1Q1IDC

AC1Q4ZGS

AKOS001715163

BB_NC-0567

BPBio1_001195

BRN 0892462

BSPBio_001085

BSPBio_003352

C-Virin

CHEMBL1643

CID37542

Copegus

Copegus (TN)

Cotronak

D00423

DB00811

DRG-0028

DivK1c_000782

Drug: Ribavirin

EU-0101063

FT-0082885

HMS2090L15

HMS2094O09

HMS502H04

HSDB 6513

ICN-1229

IDI1_000782

Ibavyr

KBio1_000782

KBio2_002328

KBio2_004896

KBio2_007464

KBio3_002854

KBioGR_001804

KBioSS_002331

KS-1104

LS-1241

Lopac0_001063

MLS000028486

MLS002222317

Moderiba

MolPort-002-507-104

MolPort-002-885-856

NCGC00090726-01

NCGC00090726-03

NCGC00090726-04

NCGC00090726-05

NCGC00090726-06

NCGC00090726-07

NINDS_000782

NSC 163039

NSC163039

Prestwick3_000993

R 9644

R-964

R9644_SIGMA

RBV

RG-964

RIBAV

RTC

RTCA

RTP

Ravanex

Rebetol

Rebetol (TN)

Rebetron

Rebretron

Ribacine

Ribamide

Ribamidil

Ribamidyl

Ribasphere

Ribasphere (TN)

Ribasphere Ribapak

Ribav

Ribavirin

Ribavirin (JAN/USP/INN)

Ribavirin Capsules

Ribavirin Triphosphate

Ribavirin [USAN:INN]

Ribavirin-TP

Ribavirina

Ribavirina [INN-Spanish]

Ribavirine

Ribavirine [INN-French]

Ribavirinum

Ribavirinum [INN-Latin]

Ribovirin

Ro 20-9963/000

Ro-20-9963

S2504_Selleck

SCH 18908

SMP1_000261

SMR000058315

SPECTRUM1503938

SR-01000076112-3

Spectrum3_001876

Spectrum4_001252

Spectrum5_002075

Spectrum_001826

Tribavirin

UNII-49717AWG6K

Varazid

Vilona

Viramid

Viramide

Virazid

Virazide

Virazole

Virazole (Ribavirin) Inhalation Solution

Virazole (TN)

Virazole 5'-triphosphate

ZINC01035331

ribavirin

2

Antiviral Agents

Phase 2

8071

3

Antimetabolites

Phase 2

9454

4

Anti-Infective Agents

Phase 2

17220

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities	Enrolling by invitation	NCT00992693	Phase 2
2	Cohort of Patients Infected by an Arbovirus	Recruiting	NCT01099852
3	Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever	Not yet recruiting	NCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

Sources:
³³MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

³³

Eye, Heart, T cells, Skin, Breast, Liver, Lung

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

Sources:
³⁸MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system	MP:0005388	8.2	CASP3, IL6, NFKB1, TNF, VEGFA
2	renal/urinary system	MP:0005367	8.1	CASP3, IL6, TLR8, TLR9, VEGFA
3	integument	MP:0010771	7.9	CASP3, F3, IL6, NFKB1, TNF, VEGFA
4	digestive/alimentary	MP:0005381	7.6	CASP3, IL6, NFKB1, TLR9, TNF, VEGFA
5	muscle	MP:0005369	7.6	CASP3, F3, IL6, NFKB1, TNF, VEGFA
6	cellular	MP:0005384	7.2	CASP3, F3, IL6, NFKB1, TLR9, TNF
7	homeostasis/metabolism	MP:0005376	6.8	CASP3, F3, IL6, NFKB1, TLR8, TLR9
8	hematopoietic system	MP:0005397	6.7	CASP3, F3, IL6, NFKB1, TLR8, TLR9
9	immune system	MP:0005387	6.4	CASP3, F3, IL6, NFKB1, TLR8, TLR9

Publications for Crimean-Congo Hemorrhagic Fever

Sources:
⁵⁴PubMed
See all MalaCards sources

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 469)

id	Title	Authors	Year
1	Possible sexual transmission of Crimean-Congo hemorrhagic fever. (26972040)	Pshenichnaya N.Y.... Zhuravlev A.S.	2016
2	Crimean-Congo hemorrhagic fever with hyperbilirubinemia and ascites: An unusual presentation. (26129885)	Ture Z.... YaA9cA+-A8aA9layA+k D.	2016
3	Crimean-Congo hemorrhagic fever - A ticking bomb? (27044612)	Al-Abri S.S.... Petersen E.	2016
4	Reply: bradycardia with ribavirin therapy in crimean-congo hemorrhagic Fever. (25760574)	Belet N.	2015
5	Consensus report: Preventive measures for Crimean-Congo Hemorrhagic Fever during Eid-al-Adha festival. (26183413)	Leblebicioglu H.... Hasan Z.	2015
6	Clinical significance of neutrophil gelatinase-associated lipocalin in Crimean-Congo hemorrhagic Fever. (25685783)	Erturk A.... Yuce S.	2015
7	Fiber-optic immunosensor for detection of Crimean-Congo hemorrhagic fever IgG antibodies in patients. (26151547)	Algaar F.... Marks R.S.	2015
8	Cytokine concentrations in pediatric patients with crimean-congo hemorrhagic Fever. (25361408)	Tezer H.... Ceylaner S.	2014
9	A novel AP92-like Crimean-Congo hemorrhagic fever virus strain, Greece. (24953797)	Papa A.... Sotiraki S.	2014
10	Prevalence of crimean-congo hemorrhagic Fever virus in healthy population, livestock and ticks in kosovo. (25393542)	Fajs L.... AvA!iA8-A1upanc T.	2014
11	Serosurvey of Crimean-Congo hemorrhagic fever virus in domestic animals, Gujarat, India, 2013. (25229708)	Mourya D.T.... Raval D.	2014
12	Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011. (23195573)	Yadav P.D.... Mourya D.T.	2013
13	Evaluation of Crimean-Congo hemorrhagic fever virus infection in children. (24107215)	KA+zA+lgun M.... Tunc B.	2013
14	Infection and propagation of Crimean-Congo hemorrhagic fever virus in embryonated chicken eggs. (23352881)	Xia H.... Li T.	2013
15	Epidemiologic features and risk factors of Crimean-Congo hemorrhagic fever in Samsun province, Turkey. (23208513)	Sisman A.	2013
16	Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever. (24270136)	Deveci K.... Alkan F.	2013
17	Influence of laboratory animal hosts on the life cycle of Hyalomma marginatum and implications for an in vivo transmission model for Crimean-Congo hemorrhagic fever virus. (23971007)	Gargili A.... Bente D.	2013
18	Temporal modeling of Crimean-Congo hemorrhagic fever in eastern Iran. (23474177)	Mostafavi E.... Haghdoost A.	2013
19	Bayesian phylogeography of crimean-congo hemorrhagic Fever virus in europe. (24223988)	Zehender G.... Ciccozzi M.	2013
20	Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)	Christova I.... Mohareb E.	2013
21	Comparative study between Ribavirin and Ribavirin plus Intravenous Immunoglobulin against Crimean Congo hemorrhagic fever. (24250699)	Salehi H.... Salehi M.	2013
22	The role of heparan sulphate in pathogenesis of Crimean-Congo hemorrhagic fever disease. (23995315)	Guven F.M.... Icagasioglu D.	2013
23	Factors associated with IgG positivity to Crimean-Congo hemorrhagic fever virus in the area with the highest seroprevalence in Greece. (23831367)	Papa A.... Tsatsaris A.	2013
24	Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya. (22925021)	Lwande O.W.... Sang R.	2012
25	Crimean-Congo hemorrhagic fever virus in various ixodid tick species from a highly endemic area. (22119389)	Tekin S.... Dundar E.	2012
26	C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever. (22695238)	Turkdogan K.A.... Yilmaz M.B.	2012
27	Relationship between Crimean-Congo hemorrhagic fever virus strains circulating in Iran and Turkey: possibilities for transborder transmission. (22925023)	Mahzounieh M.... Ozkul A.	2012
28	Effect of oral ribavirin treatment on the viral load and disease progression in Crimean-Congo hemorrhagic fever. (21106428)	Bodur H.... Kubar A.	2011
29	Co-infection of Malaria and Crimean-Congo Hemorrhagic Fever. (22347306)	Sharifi-Mood B.... Shakeri A.	2011
30	Crimean-Congo hemorrhagic fever, Afghanistan, 2009. (22000377)	Mustafa M.L.... Leslie T.	2011
31	Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness. (20403306)	Maltezou H.C.... Zeller H.	2010
32	Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. (20005156)	Ozturk B.... Tuzun H.	2010
33	Crimean-Congo hemorrhagic fever in Iran and neighboring countries. (20006541)	Chinikar S.... Haeri A.	2010
34	Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran. (20854025)	Chinikar S.... Bouloy M.	2010
35	Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: a case-control study. (19168952)	Izadi S.... Salehi M.	2009
36	Ribavirin treatment for Crimean-Congo hemorrhagic fever. (20058332)	Leblebicioglu H.	2009
37	A case of Crimean-congo hemorrhagic fever with pleural effusion. (19168966)	Tanir G.... DoksAPz O.	2009
38	Modeling the spatial distribution of crimean-congo hemorrhagic fever outbreaks in Turkey. (18047397)	Estrada-PeA+a A.... Jongejan F.	2007
39	Crimean-Congo hemorrhagic fever. (17762783)	Vorou R.... Maltezou H.C.	2007
40	Cytokine levels in Crimean-Congo hemorrhagic fever. (16765637)	Papa A.... Antoniadis A.	2006
41	A variable region in the Crimean-Congo hemorrhagic fever virus L segment distinguishes between strains isolated from different geographic regions. (16372290)	Meissner J.D.... Petrov V.S.	2006
42	Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment. (15033561)	Kinsella E.... Flick R.	2004
43	Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. (12885882)	Vincent M.J.... Nichol S.T.	2003
44	Treatment and prophylaxis with ribavirin for Crimean-Congo Hemorrhagic Fever--is it effective? (12666854)	Bangash S.A.... Khan E.A.	2003
45	Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus. (11980926)	Saijo M.... Morikawa S.	2002
46	Replication and tissue tropisms of Crimean-Congo hemorrhagic fever virus in experimentally infected adult Hyalomma truncatum (Acari: Ixodidae). (1404255)	Dickson D.L.... Turell M.J.	1992
47	Distribution of Crimean-Congo hemorrhagic fever viral antibody in Senegal: environmental and vectorial correlates. (2122750)	Wilson M.L.... Camicas J.L.	1990
48	Comparison of methods for isolation and titration of Crimean-Congo hemorrhagic fever virus. (3095367)	Shepherd A.J.... Shepherd S.P.	1986
49	Results of a preliminary seroepidemiological survey for Crimean-Congo hemorrhagic fever virus in Egypt. (25013)	Darwish M.A.... Hoogstraal H.	1978
50	(12956768)

Genes related to Crimean-Congo Hemorrhagic Fever

Sources:
²⁰GeneCards, ¹²DISEASES
See all MalaCards sources

Genes related to Crimean-Congo Hemorrhagic Fever:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	F3	Coagulation Factor III, Tissue Factor	24.52	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
2	TLR8	Toll Like Receptor 8	22.60	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
3	TNF	Tumor Necrosis Factor	22.39	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
4	IL6	Interleukin 6	22.34	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
5	NFKB1	Nuclear Factor Kappa B Subunit 1	22.09	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
6	CASP3	Caspase 3	18.84	GeneCards inferred via : Publications (show sections)
7	MX1	MX Dynamin Like GTPase 1	18.84	GeneCards inferred via : Publications (show sections)
8	VEGFA	Vascular Endothelial Growth Factor A	18.49	GeneCards inferred via : Publications (show sections)
9	TLR9	Toll Like Receptor 9	18.49	GeneCards inferred via : Publications (show sections)

Variations for Crimean-Congo Hemorrhagic Fever

Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
¹⁷Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
⁵²PathCards, ³⁹NCBI BioSystems Database, ⁵⁵QIAGEN, ⁵⁷Reactome, ³¹KEGG, ⁶²Thomson Reuters, ⁵⁶R&D Systems, ⁶³Tocris Bioscience
See all MalaCards sources

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 52)

id	Super pathways	Score	Top Affiliating Genes
1	Cytokines and Inflammatory Response³⁹	9.7	IL6, TNF
2	EBV LMP1 signaling³⁹	9.6	NFKB1, TNF
3	Canonical NF-kappaB pathway³⁹	9.6	NFKB1, TNF
4	14-3-3 and Regulation of BAD Activity⁵⁵	9.6	CASP3, TNF
5	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways⁵⁷ Show member pathways NOD pathway³⁹ NOD1/2 Signaling Pathway⁵⁷ NOD-like receptor signaling pathway³¹ Inflammasomes⁵⁷ The NLRP3 inflammasome⁵⁷ The AIM2 inflammasome⁵⁷ The NLRP1 inflammasome⁵⁷ Influenza A virus infection³⁹	9.2	IL6, NFKB1, TNF
6	amb2 Integrin signaling³⁹	9.2	IL6, NFKB1, TNF
7	Selenium Pathway³⁹ Show member pathways thioredoxin pathway³⁹	9.2	IL6, NFKB1, TNF
8	Immune response_MIF-mediated glucocorticoid regulation⁶²	9.2	IL6, NFKB1, TNF
9	Toll Comparative Pathway⁵⁵ Show member pathways IL-1 Pathway⁵⁵ Immune response MIF in innate immunity response⁶² iNOS Signaling⁵⁵ TLR-TRIF Pathway⁵⁵	9.2	IL6, NFKB1, TNF
10	IL-10 Pathway⁵⁵	9.2	IL6, NFKB1, TNF
11	Th17 Differentiation Pathway⁵⁶ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types⁵⁶	9.2	IL6, TLR8, TLR9
12	Spinal Cord Injury³⁹	9.2	CASP3, IL6, TNF
13	Dendritic Cells Developmental Lineage Pathway⁵⁶	9.2	IL6, TLR9, TNF
14	Malaria³¹	9.2	IL6, TLR9, TNF
15	African trypanosomiasis³¹	9.2	IL6, TLR9, TNF
16	MAPK Pathway⁶³ Show member pathways Toll-like Receptor Pathway⁶³	9.2	NFKB1, TLR8, TLR9
17	Ceramide Pathway⁵⁵ Show member pathways TNF-Induced Apoptosis Implicating Sphingolipids⁵⁵	9.1	CASP3, NFKB1, TNF
18	TNF-alpha/NF-kB Signaling Pathway³⁹	9.1	CASP3, NFKB1, TNF
19	Toxoplasmosis³¹ Show member pathways Leishmaniasis³¹	9.1	CASP3, NFKB1, TNF
20	IL-6 Signaling Pathway³⁹	9.1	CASP3, IL6, NFKB1
21	LPA receptor mediated events³⁹	9.1	CASP3, IL6, NFKB1
22	Immune response IFN alpha/beta signaling pathway⁶² Show member pathways Interferon alpha/beta signaling⁵⁷ Cytokine Network⁵⁵ Regulation of IFNA signaling⁵⁷	9.1	IL6, MX1, TNF
23	Rheumatoid arthritis³¹	8.9	IL6, TNF, VEGFA
24	IL27-mediated signaling events³⁹ Show member pathways Th1 Differentiation Pathway⁵⁶ IL-12 Family Signaling Pathways⁵⁶	8.8	IL6, TLR8, TLR9, TNF
25	Alzheimers disease³¹ ³⁹ Show member pathways Non-alcoholic fatty liver disease (NAFLD)³¹ Alzheimers Disease³⁹	8.7	CASP3, IL6, NFKB1, TNF
26	Amoebiasis³¹	8.7	CASP3, IL6, NFKB1, TNF
27	TWEAK Pathway⁵⁵ Show member pathways TWEAK Signaling Pathway³⁹ TNF Signaling⁵⁵ Fas Signaling⁵⁵ Apoptosis through Death Receptors⁵⁵ Apoptosis Modulation by HSP70³⁹ Apoptotic Pathways Triggered By HIV1⁵⁵ TNFR1 Pathway⁵⁵ DR3 Signaling⁵⁵ Apoptosis and survival TNFR1 signaling pathway⁶² HIV-1 Nef- Negative effector of Fas and TNF-alpha³⁹ GITR Pathway⁵⁵ TRAIL Pathway⁵⁵	8.7	CASP3, IL6, NFKB1, TNF
28	Allograft rejection³⁹ ³¹ Show member pathways Antigen processing and presentation³¹ Viral myocarditis³¹ Intestinal immune network for IgA production³¹ CTL Mediated Apoptosis⁵⁵ THC Differentiation Pathway⁵⁵ Allograft Rejection³⁹ Asthma³¹ Autoimmune thyroid disease³¹ Type I diabetes mellitus³¹ Graft-versus-host disease³¹ Inflammatory bowel disease (IBD)³¹	8.7	CASP3, IL6, NFKB1, TNF
29	Legionellosis³¹	8.7	CASP3, IL6, NFKB1, TNF
30	Pertussis³¹	8.7	CASP3, IL6, NFKB1, TNF
31	TNF signaling pathway³¹	8.7	CASP3, IL6, NFKB1, TNF
32	IgA-Producing B Cells in the Intestine⁵⁶	8.7	IL6, NFKB1, TLR9, TNF
33	Integrated Breast Cancer Pathway³⁹	8.7	CASP3, NFKB1, VEGFA
34	HIF-1 signaling pathway³¹	8.5	F3, IL6, NFKB1, VEGFA
35	NF-KappaB Family Pathway⁵⁵ Show member pathways NF-KappaB (p50-p65) Pathway⁵⁵	8.4	IL6, NFKB1, TLR8, TLR9, TNF
36	Bacterial infections in CF airways⁶² Show member pathways Immune response TLR signaling pathways⁶² Immune response Bacterial infections in normal airways⁶² IL-1 beta-dependent CFTR expression⁶²	8.4	IL6, NFKB1, TLR8, TLR9, TNF
37	Proteoglycans in cancer³¹	8.3	CASP3, IL6, TNF, VEGFA
38	Integrated Pancreatic Cancer Pathway³⁹	8.3	CASP3, NFKB1, TNF, VEGFA
39	Pathways in cancer³¹	8.3	CASP3, IL6, NFKB1, VEGFA
40	Development HGF signaling pathway⁶² Show member pathways Neurotrophin signaling pathway³¹ Apoptosis and survival NGF signaling pathway⁶² Development Neurotrophin family signaling⁶² Renal cell carcinoma³¹ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)³⁹ Apoptosis and survival Role of CDK5 in neuronal death and survival⁶² Signaling of Hepatocyte Growth Factor Receptor³⁹ Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1⁶²	8.3	CASP3, IL6, NFKB1, VEGFA
41	TRAF Pathway⁵⁵ Show member pathways 14-3-3 Induced Apoptosis⁵⁵ Toll-Like Receptors Pathway⁵⁵ TNF Superfamily Pathway⁵⁵	8.3	CASP3, NFKB1, TLR8, TLR9, TNF
42	Tuberculosis³¹	8.2	CASP3, IL6, NFKB1, TLR9, TNF
43	Toll-Like receptor Signaling Pathways⁵⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways⁵⁶ Immune response IL-1 signaling pathway⁶² IL-1 Family Signaling Pathways⁵⁶ NOD-like Receptor Signaling Pathways⁵⁶ Mucin expression in CF via TLRs, EGFR signaling pathways⁶² Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway⁶² Inflammasome Activation Pathways⁵⁶	8.0	F3, IL6, NFKB1, TLR8, TLR9, TNF
44	Akt Signaling⁵⁵ Show member pathways Tec Kinases Signaling⁵⁵ p38 Signaling⁵⁵	7.8	CASP3, IL6, NFKB1, TLR8, TLR9, TNF
45	Toll-like receptor signaling pathway³⁹ ³¹ Show member pathways Chagas disease (American trypanosomiasis)³¹ Regulation of toll-like receptor signaling pathway³⁹ Hepatitis B³¹	7.8	CASP3, IL6, NFKB1, TLR8, TLR9, TNF
46	AGE-RAGE signaling pathway in diabetic complications³¹	7.6	CASP3, F3, IL6, NFKB1, TNF, VEGFA
47	SIDS Susceptibility Pathways³⁹	7.6	CASP3, F3, IL6, NFKB1, TNF, VEGFA
48	Influenza A³¹ Show member pathways Herpes simplex infection³¹ Measles³¹	7.6	CASP3, IL6, MX1, NFKB1, TLR9, TNF
49	Immune System⁵⁷ Show member pathways Innate Immune System⁵⁷ Adaptive Immune System⁵⁷	7.2	CASP3, IL6, MX1, NFKB1, TLR8, TLR9
50	Colorectal Cancer Metastasis⁵⁵	7.0	CASP3, IL6, NFKB1, TLR8, TLR9, TNF

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
¹⁸Gene Ontology
See all MalaCards sources

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of interleukin-8 biosynthetic process	GO:0045416	10.4	TLR8, TNF
2	epithelial cell proliferation involved in salivary gland morphogenesis	GO:0060664	10.4	IL6, TNF
3	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.3	IL6, TNF
4	cellular response to nicotine	GO:0071316	10.3	NFKB1, TNF
5	regulation of cytokine secretion	GO:0050707	10.3	TLR8, TLR9
6	negative regulation of lipid storage	GO:0010888	10.2	IL6, TNF
7	positive regulation of NF-kappaB import into nucleus	GO:0042346	10.2	TLR9, TNF
8	negative regulation of fat cell differentiation	GO:0045599	10.2	IL6, TNF
9	response to antibiotic	GO:0046677	10.2	CASP3, IL6
10	negative regulation of interleukin-6 production	GO:0032715	10.1	TLR9, TNF
11	response to amino acid	GO:0043200	10.0	CASP3, IL6
12	positive regulation of interleukin-6 production	GO:0032755	10.0	IL6, TNF
13	response to bacterium	GO:0009617	10.0	IL6, NFKB1
14	positive regulation of protein complex assembly	GO:0031334	10.0	TNF, VEGFA
15	defense response to Gram-negative bacterium	GO:0050829	9.9	IL6, TLR9
16	positive regulation of cell adhesion	GO:0045785	9.7	TNF, VEGFA
17	response to glucocorticoid	GO:0051384	9.7	CASP3, IL6, TNF
18	response to wounding	GO:0009611	9.7	CASP3, F3, IL6
19	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.7	NFKB1, TLR8, TNF
20	response to virus	GO:0009615	9.6	MX1, TLR8, TNF
21	positive regulation of JUN kinase activity	GO:0043507	9.6	TLR9, TNF
22	toll-like receptor signaling pathway	GO:0002224	9.5	NFKB1, TLR8, TLR9
23	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.5	NFKB1, TLR8, TLR9
24	cellular response to lipopolysaccharide	GO:0071222	9.5	IL6, NFKB1, TNF
25	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	9.4	CASP3, F3, TNF
26	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.3	IL6, TNF, VEGFA
27	inflammatory response	GO:0006954	9.1	IL6, NFKB1, TLR8, TNF
28	response to lipopolysaccharide	GO:0032496	9.1	CASP3, F3, IL6
29	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.0	IL6, NFKB1, TLR9, TNF
30	defense response to virus	GO:0051607	8.8	IL6, MX1, TLR8
31	positive regulation of gene expression	GO:0010628	8.7	IL6, TLR9, VEGFA
32	negative regulation of apoptotic process	GO:0043066	8.5	CASP3, IL6, NFKB1, VEGFA