CCHF
MCID: CRM001
MIFTS: 64

Crimean-Congo Hemorrhagic Fever (CCHF) malady

Infectious diseases category

Summaries for Crimean-Congo Hemorrhagic Fever

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8Disease Ontology, 3CDC, 32MalaCards
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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, has material basis in crimean-congo hemorrhagic fever virus, which is transmitted by hyalomma ticks. the infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards: Crimean-Congo Hemorrhagic Fever, also known as crimean hemorrhagic fever, is related to encephalitis and cholecystitis, and has symptoms including joint pain, back pain and high fever. An important gene associated with Crimean-Congo Hemorrhagic Fever is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Leishmaniasis and Legionellosis. The compounds cycloheximide and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related mouse phenotypes are respiratory system and muscle.

CDC:3 Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was first characterized in the Crimea in 1944 and given the name Crimean hemorrhagic fever. It was then later recognized in 1969 as the cause of illness in the Congo, thus resulting in the current name of the disease.

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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8Disease Ontology, 10DISEASES, 48Orphanet, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
crimean-congo hemorrhagic fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

crimean-congo hemorrhagic fever 8 10 48
crimean hemorrhagic fever 8 48
congo hemorrhagic fever 48 60
congo-crimean hemorrhagic fever 8
hemorrhagic fever crimean-congo 44
hemorrhagic fever, crimean 60
chf congo virus 8
congo fever 48
cchf 48


External Ids:

Disease Ontology8 DOID:12287
MeSH34 D006479
NCIt39 C34682
ICD9CM27 065.0
SNOMED-CT56 43489008
ICD10 via Orphanet26 A98.0
SNOMED-CT via Orphanet57 43489008
ICD1025 A98.0

Related Diseases for Crimean-Congo Hemorrhagic Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Clinical Features for Crimean-Congo Hemorrhagic Fever

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8Disease Ontology
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Symptoms:

8 (show all 37)
  • joint pain
  • back pain
  • high fever
  • headache
  • early death/lethality
  • gingivorrhagia/gingival bleeding
  • stomach pain
  • vomiting
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • jaundice
  • nosebleeds
  • blood in the feces
  • epistaxis/nose bleeding
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • acute diarrhea
  • acute abdominal pain/colic
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • pharyngitis
  • purpura/petichiae
  • cutaneous rash
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • asthenia/fatigue/weakness
  • liver/hepatic steatosis
  • abnormal hepatic enzymes/transaminases
  • cough
  • thrombocytopenia/thrombopenia
  • leukopenia/hypoleukocytosis
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • thoracic/chest pain
  • hepatitis/icterus/cholestasis
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • myalgia/muscular pain
  • facial pain/cephalalgia/migraine
  • fever/chilling

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Crimean-Congo Hemorrhagic Fever

Drug clinical trials:

Search ClinicalTrials for Crimean-Congo Hemorrhagic Fever

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Search CenterWatch for Crimean-Congo Hemorrhagic Fever

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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32MalaCards
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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

32
Eye, Liver, Testes, Endothelial, Heart

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.6CASP3, STAB2, VEGFA, IL6
2MP:00053699.5CASP3, STAB2, F3, PARVA
3MP:00107719.3CASP3, MBTPS1, TNFRSF19, VEGFA, IL6, F2
4MP:00053909.3CASP3, MBTPS1, VEGFA, IL6
5MP:00053819.0CASP3, MBTPS1, TNF, VEGFA, NFKB1, IL6
6MP:00053829.0NFKB1, VEGFA, TNF, TNFRSF19, MBTPS1, CASP3
7MP:00053859.0CASP3, TNFRSF19, STAB2, F3, F2, PARVA
8MP:00053878.5CASP3, TLR8, MBTPS1, TNF, CHIT1, VEGFA
9MP:00053768.5PARVA, TLR8, MBTPS1, TNFRSF19, STAB2, NFKB1
10MP:00053788.2CASP3, MBTPS1, TNF, VEGFA, NFKB1, IL6
11MP:00107687.7STAB2, TNF, MBTPS1, CASP3, VEGFA, NFKB1

Publications for Crimean-Congo Hemorrhagic Fever

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Sources:
50PubMed
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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 384)
idTitleAuthorsYear
1
Evaluation of Crimean-Congo hemorrhagic fever virus infection in children. (24107215)
2013
2
Guineafowl, ticks and Crimean-Congo hemorrhagic fever in Turkey: the perfect storm? (23206535)
2013
3
Bradycardia seen in children with Crimean-Congo hemorrhagic fever. (24107209)
2013
4
Can the mild clinical course of crimean-congo hemorrhagic fever in children be explained by cytokine responses? (23893846)
2013
5
Genome Sequence of Ex-Afghanistan Crimean-Congo Hemorrhagic Fever Virus SCT Strain, from an Imported United Kingdom Case in October 2012. (23682136)
2013
6
Crimean-Congo hemorrhagic fever nosocomial infection in a immunosuppressed patient, Pakistan: case report and virological investigation. (23172105)
2013
7
Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway. (23791227)
2013
8
Human defined antigenic region on the nucleoprotein of Crimean-Congo hemorrhagic fever virus identified using truncated proteins and a bioinformatics approach. (23933073)
2013
9
Diagnostic and prognostic value of Ischemia-modified albumin in patients with Crimean-Congo hemorrhagic fever. (23364834)
2013
10
New circulating genomic variant of Crimean-Congo hemorrhagic fever virus in Iran. (23271164)
2013
11
Evaluation of patients with Crimean-Congo hemorrhagic fever in Bolu, Turkey. (24235918)
2013
12
Expression of interferon-induced antiviral genes is delayed in a STAT1 knockout mouse model of Crimean-Congo hemorrhagic fever. (22713837)
2012
13
Migratory birds, ticks, and crimean-congo hemorrhagic fever virus. (23171591)
2012
14
Relationship between total thiol status and thrombocytopenia in patients with Crimean-Congo hemorrhagic fever. (23413704)
2012
15
Serological evaluation of Crimean-Congo hemorrhagic fever in humans with high-risk professions living in enzootic regions of Isfahan province of Iran and genetic analysis of circulating strains. (22217167)
2012
16
Parotitis associated with Crimean Congo hemorrhagic fever virus. (22079303)
2012
17
Detection, isolation and confirmation of Crimean-Congo hemorrhagic fever virus in human, ticks and animals in Ahmadabad, India, 2010-2011. (22616022)
2012
18
Seroepidemiology of crimean congo hemorrhagic Fever in slaughterhouse workers in north eastern iran. (23304679)
2012
19
A new perspective to determine the severity of cases with Crimean-Congo hemorrhagic fever. (22898483)
2012
20
Multiple Crimean-Congo hemorrhagic fever virus strains are associated with disease outbreaks in Sudan, 2008-2009. (21655310)
2011
21
The early prediction of fatality in Crimean Congo hemorrhagic fever patients. (21748216)
2011
22
Crimean-Congo hemorrhagic fever in Iran and neighboring countries. (20006541)
2010
23
Current treatment of Crimean-Congo hemorrhagic fever in children. (20695747)
2010
24
Coagulopathy parameters in patients with Crimean-Congo hemorrhagic fever and its relation with mortality. (20486197)
2010
25
Crimean-Congo hemorrhagic fever in a dengue-endemic region: lessons for the future. (20818095)
2010
26
The effectiveness of routine laboratory findings in determining disease severity in patients with Crimean-Congo hemorrhagic fever: severity prediction criteria. (20149724)
2010
27
Molecular epidemiology of Crimean-Congo hemorrhagic fever virus in Turkey: occurrence of local topotype. (20079776)
2010
28
Detection of Crimean-Congo hemorrhagic fever virus genome in saliva and urine. (19656706)
2010
29
Epidemiology and phylogenetic analysis of crimean-congo hemorrhagic fever viruses in xinjiang, china. (19553586)
2009
30
Crimean-Congo hemorrhagic fever in southeastern Europe. (19540787)
2009
31
Ocular findings in patients with Crimean-Congo hemorrhagic fever. (19195635)
2009
32
Crimean Congo hemorrhagic fever and diffuse alveolar haemorrhage. (18820205)
2008
33
The risk of transmission of Crimean-Congo hemorrhagic fever virus from human cases to first-degree relatives. (19050365)
2008
34
Plasma activity of thrombin activatable fibrinolysis inhibitor in Crimean-Congo hemorrhagic fever. (17418898)
2007
35
Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients. (18214191)
2007
36
Crimean-Congo hemorrhagic fever in Southeast of Iran. (16182370)
2006
37
Seroprevalence of Crimean-Congo hemorrhagic fever in Sistan-va-Baluchestan province of Iran. (17060701)
2006
38
Type I interferon inhibits Crimean-Congo hemorrhagic fever virus in human target cells. (16372299)
2006
39
Cellular localization and antigenic characterization of crimean-congo hemorrhagic fever virus glycoproteins. (15858000)
2005
40
Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment. (15033561)
2004
41
Crimean-Congo hemorrhagic fever in Bulgaria. (15496250)
2004
42
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. (12885882)
2003
43
A patient with Crimean-Congo hemorrhagic fever serologically diagnosed by recombinant nucleoprotein-based antibody detection systems. (12738657)
2003
44
Crimean-Congo hemorrhagic fever in Kosovo. (11880460)
2002
45
First documentation of human Crimean-Congo hemorrhagic fever, Kenya. (12194785)
2002
46
Experimental vector incompetence of a soft tick, Ornithodoros sonrai (Acari: Argasidae), for Crimean-Congo hemorrhagic fever virus. (8459431)
1993
47
Replication and tissue tropisms of Crimean-Congo hemorrhagic fever virus in experimentally infected adult Hyalomma truncatum (Acari: Ixodidae). (1404255)
1992
48
Comparison of the S RNA segments and nucleoprotein sequences of Crimean-Congo hemorrhagic fever, Hazara, and Dugbe viruses. (1641991)
1992
49
Distribution of Crimean-Congo hemorrhagic fever viral antibody in Senegal: environmental and vectorial correlates. (2122750)
1990
50
Antibody response in Crimean-Congo hemorrhagic fever. (2501854)
1989

Genetic Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 53Reactome, 52R&D Systems
See all sources

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3NFKB1
210.1NFKB1, CASP3
39.9IL6, NFKB1, CASP3
4
Hide members
9.8NFKB1, TNF, CASP3
5
Immune response Bacterial infections in normal airways
9.8TNF, NFKB1, IL6
69.8IL6, NFKB1, TNF
79.8TNF, NFKB1, IL6
89.8TNF, NFKB1, IL6
9
Hide members
9.8IL6, NFKB1, TNF
109.8TLR8, NFKB1, IL6
11
Hide members
9.8TLR8, TNF, IL6
12
Hide members
9.8TLR8, TNF, IL6
13
Hide members
9.7NFKB1, TNFRSF19, CASP3
14
Development PDGF signaling via STATs and NF-kB
Hide members
9.7F2, IL6, NFKB1, TNF
159.7TNF, NFKB1, IL6, F2
16
Hide members
9.6F3, IL6, NFKB1, TNF
179.6IL6, NFKB1, TNF, CASP3
18
Hide members
9.6CASP3, TNF, NFKB1, IL6
199.6CASP3, TNF, NFKB1, IL6
209.6CASP3, TNF, NFKB1, IL6
219.6IL6, NFKB1, TNF, CASP3
22
Hide members
9.6ISG20, NFKB1, IL6, MX1
239.6NFKB1, VEGFA, TNF, CASP3
24
Hide members
9.6TLR8, TNF, NFKB1, IL6
25
Hide members
9.5CASP3, TNF, NFKB1, IL6, MX1
269.4CASP3, TNF, VEGFA, NFKB1, IL6
279.4CASP3, TLR8, TNF, NFKB1, IL6
28
Hide members
9.4CASP3, TLR8, TNF, NFKB1, IL6
29
Hide members
9.2NFKB1, TNF, TNFRSF19, TLR8, CASP3

Compounds for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6MX1
2prednisolone44 28 1112.5SLC17A5
3aprotinin44 1111.5SLC17A5, F3
4pdtc4410.5IL6, F3
5aprosulate4410.4F3, F2
6brodifacoum4410.4F2, F3
7napsagatran4410.4F2, F3
8ximelagatran44 1111.4GPT, F2, F3
9troglitazone44 28 59 1113.3GPT, SLC17A5, CASP3
10aminopyrine4410.3SLC17A5, GPT, F2
11hemochron4410.3F2, F3
12certoparin4410.3F3, F2
13gm-csf44 2811.3TNF
14d-galactosamine4410.3GPT, TNF, SLC17A5
15appt4410.3F2, F3
16lamivudine44 1111.2F2, SLC17A5
17hepaplastin4410.2SLC17A5, GPT, F3, F2
18levonorgestrel44 59 28 1113.2F3, F2, SLC17A5
19nash4410.2TNF, CHIT1, SLC17A5, GPT
20tpck4410.2IL6, CASP3, TNF
21silymarin4410.1SLC17A5, GPT, F2, VEGFA
22cyclosporin a44 28 5912.1GPT, F2, RNPC3, SLC17A5
23pge14410.1IL6, GPT, SLC17A5, F2
24zoledronic acid4410.1IL6, VEGFA, CASP3
25ribavirin44 49 1112.1ISG20, MX1, SLC17A5, GPT
26fenofibrate44 49 1112.1TNF, IL6, GPT, SLC17A5
27protamine4410.0RNPC3, F2, F3, IL6
28imiquimod44 28 59 1113.0TNF, MX1, IL6, TLR8
29triptolide4410.0TNF, IL6, CASP3, VEGFA
30poly(i-c)4410.0TLR8, IL6, MX1, TNF
31aebsf4410.0F3, TNF, MBTPS1, CASP3
3215-deoxy-delta-12,14-prostaglandin j24410.0VEGFA, CASP3, IL6, TNF
33sp 60012544 5911.0CASP3, TNF, IL6, F3
34thalidomide44 49 59 1113.0IL6, VEGFA, TNF, NFKB1
35rosuvastatin44 49 28 1112.9IL6, GPT, SLC17A5
36rosiglitazone44 49 28 11 2413.9IL6, SLC17A5, GPT, TNF
37pioglitazone44 49 28 1112.9GPT, IL6, VEGFA, TNF, SLC17A5
38methotrexate44 49 1111.9TNF, SLC17A5, F2, GPT, IL6
39atorvastatin44 49 28 11 2413.9SLC17A5, GPT, VEGFA, TNF, IL6
402,5-oligoadenylate449.9GPT, MX1, TNF, ISG20, IL6
41neopterin449.8SLC17A5, MX1, GPT, IL6, CHIT1, TNF
42sb 20358044 5910.8CASP3, TNF, VEGFA, F3, IL6
43parthenolide44 210.7CASP3, IL6, TNF
44lactate449.7SLC17A5, F2, IL6, GPT, CASP3, TNF
45fibrinogen449.6GPT, F3, IL6, CHIT1, SLC17A5, TNF
46hyaluronic acid44 2410.5SLC17A5, GPT, IL6, VEGFA, STAB2, F2
47ciglitazone44 2810.5TNF, CASP3, IL6
48n acetylcysteine449.5CASP3, TNF, IL6, GPT, F2, SLC17A5
49actinomycin d449.4TNF, VEGFA, IL6, F3, CASP3
50simvastatin44 49 59 28 11 2414.4TNF, GPT, VEGFA, IL6, F3, CASP3

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
16Gene Ontology
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Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.3F2, F3, IL6, VEGFA, CHIT1, TNF

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.1IL6, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1IL6, TNF
3negative regulation of viral genome replicationGO:04507110.0TNF, ISG20, MX1
4positive regulation of peptidyl-serine phosphorylationGO:03313810.0TNF, VEGFA, IL6
5positive regulation of interleukin-8 biosynthetic processGO:0454169.9TNF, TLR8
6positive regulation of protein phosphorylationGO:0019349.8F2, VEGFA, TNF
7positive regulation of protein kinase B signaling cascadeGO:0518979.8TNF, IL6, F3
8positive regulation of positive chemotaxisGO:0509279.8F3, VEGFA
9response to virusGO:0096159.8MX1, ISG20, TNF, TLR8
10defense response to virusGO:0516079.7MX1, IL6, ISG20, TLR8
11regulation of cell shapeGO:0083609.7PARVA, F2, IL6, VEGFA

Products for genes affiliated with Crimean-Congo Hemorrhagic Fever

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  • Antibodies
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Sources for Crimean-Congo Hemorrhagic Fever

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet