MCID: CRM001
MIFTS: 58

Crimean-Congo Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

MalaCards integrated aliases for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 12 55 3 14
Hemorrhagic Fever, Crimean 41 69
Congo Hemorrhagic Fever 55 69
Cchf 55 3
Crimean Hemorrhagic Fever [chf Congo Virus] 12
Congo-Crimean Hemorrhagic Fever 12
Hemorrhagic Fever Crimean-Congo 51
Crimean Hemorrhagic Fever 55
Chf Congo Virus 12
Congo Fever 55

Characteristics:

Orphanet epidemiological data:

55
crimean-congo hemorrhagic fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Crimean-Congo Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary : Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to hemorrhagic fever and leptospirosis, and has symptoms including headache, high fever and back pain. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

CDC : 3 Crimean-Congo hemorrhagic fever is found in Eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

Related Diseases for Crimean-Congo Hemorrhagic Fever

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 32.2 F3 IL6 TNF
2 leptospirosis 30.1 IL6 PIK3C2A TNF
3 hemorrhagic fever with renal syndrome 30.0 IL6 TNF
4 malaria 29.1 CXCL10 F3 IL6 TNF
5 rift valley fever 10.5
6 coccidioidomycosis 10.5
7 endotheliitis 10.4
8 erysipelas 10.4 PIK3C2A TNF
9 compartment syndrome 10.3 PIK3C2A TNF
10 scrub typhus 10.3 F3 TNF
11 pyoderma 10.3 F3 TNF
12 severe hemophilia a 10.3 F3 TNF
13 west nile virus 10.3
14 tick-borne encephalitis 10.3
15 encephalitis 10.3
16 vibrio vulnificus infection 10.2 IL6 PIK3C2A
17 angina pectoris 10.2 F3 IL6
18 cardiogenic shock 10.2 IL6 PIK3C2A
19 multicentric castleman disease 10.2 F3 IL6
20 acute cholangitis 10.2 IL6 TREM1
21 scorpion envenomation 10.2 IL6 TNF
22 relapsing polychondritis 10.2 IL6 TREM1
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
24 critical limb ischemia 10.2 IL6 TNF
25 streptococcal toxic-shock syndrome 10.2 IL6 TNF
26 null-cell leukemia 10.2 IL6 TNF
27 retinitis pigmentosa 55 10.2 IL6 TNF
28 glossitis 10.2 IL6 TNF
29 laryngitis 10.2 IL6 TNF
30 anterior uveitis 10.2 IL6 TNF
31 acute vascular insufficiency of intestine 10.2 IL6 TNF
32 posterior urethral valves 10.2 IL6 TNF
33 poems syndrome 10.2 IL6 TNF
34 microscopic colitis 10.2 IL6 TNF
35 meconium aspiration syndrome 10.2 IL6 TNF
36 burning mouth syndrome 10.2 IL6 TNF
37 central nervous system vasculitis 10.2 IL6 TNF
38 osteosclerotic myeloma 10.2 IL6 TNF
39 stachybotrys chartarum 10.2 IL6 TNF
40 respiratory failure 10.2 F3 PIK3C2A TNF
41 louse-borne relapsing fever 10.2 IL6 TNF
42 listeriosis 10.2 IL6 TNF
43 transverse myelitis 10.1 IL6 TNF
44 ischemic heart disease 10.1 IL6 TNF
45 intermediate uveitis 10.1 IL6 TNF
46 monoclonal gammopathy of uncertain significance 10.1 IL6 TNF
47 post-transplant lymphoproliferative disease 10.1 IL6 TNF
48 eales disease 10.1 IL6 TNF
49 myelitis 10.1 IL6 TNF
50 nonalcoholic steatohepatitis 10.1 IL6 TNF

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to Crimean-Congo Hemorrhagic Fever

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

Symptoms:

12 (show all 13)
  • headache
  • high fever
  • back pain
  • joint pain
  • stomach pain
  • vomiting
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • jaundice
  • nosebleeds
  • blood in the feces

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

55 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 gingival bleeding 55 31 occasional (7.5%) Occasional (29-5%) HP:0000225
2 epistaxis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000421
3 uveitis 55 31 frequent (33%) Frequent (79-30%) HP:0000554
4 jaundice 55 31 occasional (7.5%) Occasional (29-5%) HP:0000952
5 petechiae 55 31 frequent (33%) Frequent (79-30%) HP:0000967
6 skin rash 55 31 frequent (33%) Frequent (79-30%) HP:0000988
7 hepatic steatosis 55 31 frequent (33%) Frequent (79-30%) HP:0001397
8 thrombocytopenia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001873
9 leukopenia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001882
10 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
11 diarrhea 55 31 frequent (33%) Frequent (79-30%) HP:0002014
12 nausea and vomiting 55 31 frequent (33%) Frequent (79-30%) HP:0002017
13 abdominal pain 55 31 frequent (33%) Frequent (79-30%) HP:0002027
14 gastrointestinal hemorrhage 55 31 occasional (7.5%) Occasional (29-5%) HP:0002239
15 headache 55 31 frequent (33%) Frequent (79-30%) HP:0002315
16 elevated hepatic transaminases 55 31 frequent (33%) Frequent (79-30%) HP:0002910
17 myalgia 55 31 frequent (33%) Frequent (79-30%) HP:0003326
18 cardiorespiratory arrest 55 31 occasional (7.5%) Occasional (29-5%) HP:0006543
19 fatigue 55 31 hallmark (90%) Very frequent (99-80%) HP:0012378
20 cough 55 31 frequent (33%) Frequent (79-30%) HP:0012735
21 chest pain 55 31 occasional (7.5%) Occasional (29-5%) HP:0100749
22 recurrent pharyngitis 55 31 frequent (33%) Frequent (79-30%) HP:0100776
23 abnormal bleeding 55 Occasional (29-5%)

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CXCL10 F3 IL6 NFKB1 PIK3C2A TLR8
2 homeostasis/metabolism MP:0005376 9.56 CXCL10 F3 IL6 NFKB1 PIK3C2A TLR8
3 immune system MP:0005387 9.23 CXCL10 F3 IL6 NFKB1 PIK3C2A TLR8

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2 Anti-Infective Agents Phase 2
3 Antimetabolites Phase 2
4 Antiviral Agents Phase 2
5
Formaldehyde Approved, Vet_approved Phase 1 50-00-0 712
6 Pharmaceutical Solutions Phase 1
7 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2 Ribavirin (Virazole) Injection
2 Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans Completed NCT03020771 Phase 1
3 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
4 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260 Ribavirin

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

38
Eye, Skin, Endothelial, Testes, Heart, Neutrophil

Publications for Crimean-Congo Hemorrhagic Fever

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 540)
# Title Authors Year
1
Host preferences support the prominent role of Hyalomma ticks in the ecology of Crimean-Congo hemorrhagic fever. ( 29420542 )
2018
2
Analysis of codon usage bias of Crimean-Congo hemorrhagic fever virus and its adaptation to hosts. ( 29198972 )
2018
3
Lethal infection of embryonated chicken eggs by Hazara virus, a model for Crimean-Congo hemorrhagic fever virus. ( 29030708 )
2018
4
Structure-Function Assays for Crimean-Congo Hemorrhagic Fever Virus Polymerase. ( 28986838 )
2018
5
Characteristics of headache and its relationship with disease severity in patients with Crimean-Congo hemorrhagic fever. ( 29450871 )
2018
6
Evaluation of the associations between endothelial dysfunction, inflammation and coagulation in Crimean-Congo hemorrhagic fever patients. ( 29159591 )
2018
7
Phylodynamics of Crimean Congo hemorrhagic fever virus in South Russia. ( 29413882 )
2018
8
A novel double-antigen sandwich ELISA for the species-independent detection of Crimean-Congo hemorrhagic fever virus-specific antibodies. ( 29330092 )
2018
9
Dynamics of viral load in Crimean Congo hemorrhagic fever. ( 29091325 )
2018
10
Sequence Optimized Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection of Crimean-Congo Hemorrhagic Fever Virus. ( 29165231 )
2018
11
Investigation of an isolated case of human Crimean-Congo hemorrhagic fever in Central Uganda, 2015. ( 29382607 )
2018
12
Second International Conference on Crimean-Congo Hemorrhagic Fever. ( 29199036 )
2018
13
Seroepidemiology and risk factors of Crimean-Congo Hemorrhagic Fever among butchers and slaughterhouse workers in southeastern Iran. ( 28935247 )
2017
14
A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models. ( 28922426 )
2017
15
Space-time epidemiology of Crimean-Congo hemorrhagic fever (CCHF) in Iran. ( 28943247 )
2017
16
Co-circulation of Crimean-Congo Hemorrhagic Fever virus strains Asia 1 and 2 between the border of Iran and Pakistan. ( 29159319 )
2017
17
Effect of TLR10 (2322A/G, 720A/C, and 992T/A) polymorphisms on the pathogenesis of Crimean Congo hemorrhagic fever disease. ( 28843003 )
2017
18
Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease. ( 28877473 )
2017
19
Brucellosis in Patients with Crimean-Congo Hemorrhagic Fever. ( 29367923 )
2017
20
Infection prevention and control practice for Crimean-Congo hemorrhagic fever-A multi-center cross-sectional survey in Eurasia. ( 28886039 )
2017
21
Crimean-Congo hemorrhagic fever virus in ticks collected from livestock in Albania. ( 28827176 )
2017
22
Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks. ( 28736753 )
2017
23
Crimean Congo hemorrhagic fever among the one-humped camel (Camelus dromedaries) in Central Sudan. ( 28774342 )
2017
24
Serosurvey of Crimean-Congo Hemorrhagic Fever Virus in Cattle, Mali, West Africa. ( 28719259 )
2017
25
Is hemorrhage the reason in crimean-congo hemorrhagic fever patients with neurological signs and symptomsa. ( 29192635 )
2017
26
Crimean-Congo Hemorrhagic Fever in Spain - New Arrival or Silent Resident? ( 28700846 )
2017
27
Tetracyclines as a potential antiviral therapy against Crimean Congo hemorrhagic fever virus: Docking and molecular dynamic studies. ( 28709136 )
2017
28
Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014. ( 28836897 )
2017
29
Molecular detection of Crimean-Congo hemorrhagic fever virus in ticks, Greece, 2012-2014. ( 28920177 )
2017
30
Generic amplification and next generation sequencing reveal Crimean-Congo hemorrhagic fever virus AP92-like strain and distinct tick phleboviruses in Anatolia, Turkey. ( 28705183 )
2017
31
Phylogenetic Characterization of Crimean-Congo Hemorrhagic Fever Virus, Spain. ( 29148370 )
2017
32
Crimean-Congo hemorrhagic fever virus nucleocapsid protein has dual RNA binding modes. ( 28922369 )
2017
33
A neonatal death associated with Crimean-Congo hemorrhagic fever (Republic of Kalmykia, Russia, June 2016). ( 28870741 )
2017
34
Summer crisis in Iran: increase in reported cases of Crimean-Congo Hemorrhagic Fever (CCHF). ( 29184754 )
2017
35
Serosurvey for Crimean-Congo hemorrhagic fever virus infections in ruminants in Katanga province, Democratic Republic of the Congo. ( 28712556 )
2017
36
Identification of broadly neutralizing monoclonal antibodies against Crimean-Congo hemorrhagic fever virus. ( 28842265 )
2017
37
Increased Levels of VEGF-A and HIF-1I+ in Turkish Children with Crimean-Congo Hemorrhagic Fever. ( 29026849 )
2017
38
Genome Sequences of Crimean-Congo Hemorrhagic Fever Virus Strains Isolated in South Africa, Namibia, and Turkey. ( 29051241 )
2017
39
Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. ( 29024765 )
2017
40
Biosafety standards for working with Crimean-Congo hemorrhagic fever virus. ( 27667586 )
2016
41
Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana. ( 27392037 )
2016
42
Examination of the specific clinical symptoms and laboratory findings of Crimean-Congo hemorrhagic fever. ( 27353587 )
2016
43
MicroRNA expression profiles in patients with acute Crimean Congo Hemorrhagic Fever reveal possible adjustments to cellular pathways. ( 27551771 )
2016
44
Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. ( 27353580 )
2016
45
Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran. ( 27308275 )
2016
46
Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. ( 27110812 )
2016
47
Crimean-Congo hemorrhagic fever - A ticking bomb? ( 27044612 )
2016
48
Crimean-Congo hemorrhagic fever with hyperbilirubinemia and ascites: An unusual presentation. ( 26129885 )
2016
49
Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity. ( 27775001 )
2016
50
Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses. ( 27217069 )
2016

Variations for Crimean-Congo Hemorrhagic Fever

Expression for Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for Crimean-Congo Hemorrhagic Fever

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CXCL10 IFNA17 IL6 NFKB1 TLR8 TNF
2
Show member pathways
13.24 CXCL10 IL6 NFKB1 TLR8 TNF
3
Show member pathways
13.19 CXCL10 IFNA17 IL6 NFKB1 TNF
4
Show member pathways
13.04 NFKB1 PIK3C2A TLR8 TNF TREM1
5
Show member pathways
12.82 IFNA17 IL6 NFKB1 TNF
6
Show member pathways
12.58 CXCL10 IFNA17 IL6 NFKB1 TNF
7
Show member pathways
12.56 F3 IFNA17 IL6 NFKB1 TLR8 TNF
8
Show member pathways
12.55 IL6 NFKB1 TLR8 TNF
9
Show member pathways
12.44 CXCL10 IFNA17 IL6 NFKB1 TNF
10
Show member pathways
12.42 IFNA17 IL6 NFKB1 TNF
11 12.41 CXCL10 NFKB1 TLR8 TNF
12
Show member pathways
12.3 IL6 NFKB1 TNF
13 12.29 IL6 NFKB1 TNF
14
Show member pathways
12.2 IL6 NFKB1 TNF
15
Show member pathways
12.18 CXCL10 IL6 NFKB1 TNF
16
Show member pathways
12.17 IFNA17 IL6 NFKB1
17
Show member pathways
12.13 IL6 NFKB1 TNF
18
Show member pathways
12.09 IL6 NFKB1 TLR8 TNF
19 12.04 IL6 NFKB1 TNF
20 12.03 IFNA17 IL6 NFKB1 TNF
21
Show member pathways
12.02 IFNA17 IL6 TNF
22 11.98 IL6 NFKB1 TLR8 TNF
23 11.94 IFNA17 NFKB1 TNF
24
Show member pathways
11.9 NFKB1 PIK3C2A TLR8
25 11.88 CXCL10 IL6 TNF
26
Show member pathways
11.83 IL6 NFKB1 TNF
27
Show member pathways
11.8 IL6 TLR8 TNF
28 11.76 IL6 NFKB1 TNF
29 11.66 CXCL10 IL6 NFKB1 TNF
30 11.64 IL6 NFKB1 TNF
31
Show member pathways
11.59 CXCL10 IFNA17 IL6 NFKB1 TLR8 TNF
32 11.57 IL6 NFKB1 TNF
33
Show member pathways
11.57 CXCL10 IL6 NFKB1 TLR8 TNF
34
Show member pathways
11.54 IL6 NFKB1 TNF
35 11.47 IL6 NFKB1 TNF
36 11.45 F3 IL6 NFKB1 TNF
37 11.4 CXCL10 IL6 TNF
38 11.38 IL6 NFKB1 TNF
39 11.24 IL6 TNF
40 11.21 IL6 NFKB1
41 11.2 IL6 TNF
42 11.16 IL6 TNF
43 11.15 IL6 NFKB1 TNF
44 11.08 CXCL10 IL6 TNF
45 11.05 NFKB1 TNF
46 11.04 IL6 NFKB1 TNF
47 11.03 NFKB1 TNF
48 11 IL6 TNF
49 10.93 IL6 TNF
50 10.87 CXCL10 IL6 NFKB1 TNF

GO Terms for Crimean-Congo Hemorrhagic Fever

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CXCL10 F3 IFNA17 IL6 NFKB1 TNF
2 external side of plasma membrane GO:0009897 9.13 CXCL10 TLR8 TNF

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.85 IFNA17 NFKB1 TLR8 TREM1
2 regulation of receptor activity GO:0010469 9.78 CXCL10 IFNA17 IL6 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.7 F3 IFNA17 IL6
4 defense response GO:0006952 9.69 CXCL10 IFNA17 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 IL6 NFKB1 TNF
6 inflammatory response GO:0006954 9.65 CXCL10 IL6 NFKB1 TLR8 TNF
7 defense response to virus GO:0051607 9.62 CXCL10 IFNA17 IL6 TLR8
8 negative regulation of myoblast differentiation GO:0045662 9.56 CXCL10 TNF
9 positive regulation of chemokine production GO:0032722 9.54 IL6 TNF
10 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.54 NFKB1 TLR8 TNF
11 negative regulation of lipid storage GO:0010888 9.46 IL6 TNF
12 cellular response to lipopolysaccharide GO:0071222 9.46 CXCL10 IL6 NFKB1 TNF
13 cellular response to nicotine GO:0071316 9.43 NFKB1 TNF
14 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.4 TLR8 TNF
15 response to virus GO:0009615 9.26 CXCL10 IFNA17 TLR8 TNF
16 humoral immune response GO:0006959 8.92 IFNA17 IL6 TNF TREM1

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL10 IFNA17 IL6 TNF

Sources for Crimean-Congo Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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