MCID: CRM001
MIFTS: 53

Crimean-Congo Hemorrhagic Fever malady

Categories: Genetic diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 2CDC, 48Novoseek, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 43NCIt, 29ICD10 via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 11 13 52 2
Hemorrhagic Fever, Crimean 37 66
Crimean Hemorrhagic Fever 11 52
Cchf 52 2
Congo-Crimean Hemorrhagic Fever 11
 
Hemorrhagic Fever Crimean-Congo 48
Congo Hemorrhagic Fever 52
Chf Congo Virus 11
Congo Fever 52

Characteristics:

Orphanet epidemiological data:

52
crimean-congo hemorrhagic fever:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:12287
ICD1028 A98.0
ICD9CM30 065.0
MeSH37 D006479
SNOMED-CT60 43489008
NCIt43 C34682
Orphanet52 ORPHA99827
ICD10 via Orphanet29 A98.0

Summaries for Crimean-Congo Hemorrhagic Fever

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Disease Ontology:11 A viral infectious disease that is a hemorrhagic fever, has material basis in crimean-congo hemorrhagic fever virus, which is transmitted by hyalomma ticks. the infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to tick-borne encephalitis and hemophagocytic lymphohistiocytosis, and has symptoms including abnormality of temperature regulation, skin rash and hepatic steatosis. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways are Cytokines and Inflammatory Response and Canonical NF-kappaB pathway. Affiliated tissues include eye, skin and testes, and related mouse phenotypes are muscle and digestive/alimentary.

Related Diseases for Crimean-Congo Hemorrhagic Fever

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Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1tick-borne encephalitis30.7MX1, TNF
2hemophagocytic lymphohistiocytosis30.4IL6, TNF
3malaria28.1CXCL10, F3, IL6, TLR9, TNF
4hemorrhagic fever11.5
5rift valley fever10.5
6endotheliitis10.4
7amelogenesis imperfecta hypomaturation type10.4CASP3, IL6
8malignant histiocytosis10.3MX1, TNF
9tonsillar fossa cancer10.3CASP3, IL6
10west nile virus10.3
11encephalitis10.3
12ulcerative colitis10.3CASP3, IL6
13idiopathic central precocious puberty10.3F3, TNF
14chronic diarrhea due to guanylate cyclase 2c overactivity10.2F3, IL6
15panner disease10.2IL6, TNF
16idiopathic neutropenia10.2F3, IL6
17aortic arch interruption10.2IL6, TNF
18cutaneous leishmaniasis10.2IL6, TNF
19maligant granulosa cell tumor of ovary10.2IL6, TNF
20hemometra10.2IL6, TNF
21tricho odonto onycho dermal syndrome10.2IL6, TNF
22sweat gland cancer10.2F3, IL6
23scrotum paget's disease10.2IL6, TNF
24epstein-barr virus hepatitis10.2IL6, TNF
25abdominal chemodectomas with cutaneous angiolipomas10.2IL6, TNF
26antigen-peptide-transporter 2 deficiency10.2IL6, TNF
27hypothyroidism10.2IL6, TNF
28ethmoid sinus adenoid cystic carcinoma10.2IL6, TNF
29autoimmune polyendocrine syndrome10.2IL6, TNF
30splenic manifestation of prolymphocytic leukemia10.2IL6, TNF
31post-infectious myocarditis10.2IL6, TNF
32skin disease10.2IL6, TNF
33pasteurellosis10.2IL6, TNF
34scarlet fever10.2IL6, TNF
35lymphocytic colitis10.2IL6, TNF
36non-secretory myeloma10.2IL6, TNF
37qualitative platelet defect10.1IL6, TNF
38sterility due to immotile flagella10.1IL6, TNF
39pulmonary hypertension10.1
40thrombocytopenia10.1
41parotitis10.1
42thrombotic thrombocytopenic purpura10.1
43hemorrhagic fever with renal syndrome10.1
44cholecystitis10.1
45post-traumatic stress disorder10.1
46leptospirosis10.1
47acalculous cholecystitis10.1
48acute pancreatitis10.1
49ischemia10.1
50purpura10.1

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Symptoms for Crimean-Congo Hemorrhagic Fever

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Symptoms:

 11 52 (show all 34)
  • headache
  • high fever
  • back pain
  • joint pain
  • stomach pain
  • vomiting
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • jaundice
  • nosebleeds
  • blood in the feces
  • gingival bleeding
  • epistaxis
  • uveitis
  • petechiae
  • skin rash
  • hepatic steatosis
  • thrombocytopenia
  • leukopenia
  • abnormal bleeding
  • fever
  • diarrhea
  • nausea and vomiting
  • abdominal pain
  • gastrointestinal hemorrhage
  • elevated hepatic transaminases
  • myalgia
  • cardiorespiratory arrest
  • fatigue
  • cough
  • chest pain
  • recurrent pharyngitis

HPO human phenotypes related to Crimean-Congo Hemorrhagic Fever:

(show all 20)
id Description Frequency HPO Source Accession
1 abnormality of temperature regulation hallmark (90%) HP:0004370
2 skin rash typical (50%) HP:0000988
3 hepatic steatosis typical (50%) HP:0001397
4 subcutaneous hemorrhage typical (50%) HP:0001933
5 diarrhea typical (50%) HP:0002014
6 nausea and vomiting typical (50%) HP:0002017
7 abdominal pain typical (50%) HP:0002027
8 migraine typical (50%) HP:0002076
9 elevated hepatic transaminases typical (50%) HP:0002910
10 myalgia typical (50%) HP:0003326
11 inflammatory abnormality of the eye typical (50%) HP:0100533
12 recurrent pharyngitis typical (50%) HP:0100776
13 gingival bleeding occasional (7.5%) HP:0000225
14 epistaxis occasional (7.5%) HP:0000421
15 sudden cardiac death occasional (7.5%) HP:0001645
16 thrombocytopenia occasional (7.5%) HP:0001873
17 leukopenia occasional (7.5%) HP:0001882
18 abnormality of coagulation occasional (7.5%) HP:0001928
19 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
20 chest pain occasional (7.5%) HP:0100749

UMLS symptoms related to Crimean-Congo Hemorrhagic Fever:


hemoptysis, cullen's sign, traumatic hematuria, mucosal haemorrhage, nail bed hemorrhage

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinPhase 296836791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
3Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverNot yet recruitingNCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever


Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

34
Eye, Skin, Testes, Endothelial, Heart, Neutrophil

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

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MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3CASP3, F3, IL6, NFKB1, TNF
2MP:00053817.9CASP3, IL6, NFKB1, TLR9, TNF
3MP:00053847.4CASP3, CXCL10, F3, IL6, NFKB1, TLR9
4MP:00053877.2CASP3, CXCL10, F3, IL6, NFKB1, TLR8
5MP:00053977.0CASP3, CXCL10, F3, IL6, NFKB1, TLR8
6MP:00053766.9CASP3, CXCL10, F3, IL6, NFKB1, TLR8

Publications for Crimean-Congo Hemorrhagic Fever

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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Does Crimean-Congo Hemorrhagic Fever Cause a Vasculitic Reaction with Pulmonary Artery Enlargement and Acute Pulmonary Hypertension? (27344326)
2016
2
Possible sexual transmission of Crimean-Congo hemorrhagic fever. (26972040)
2016
3
Crimean-Congo hemorrhagic fever - A ticking bomb? (27044612)
2016
4
Crimean-Congo hemorrhagic fever virus lineages Europe 1 and Europe 2 in Bulgarian ticks. (27378409)
2016
5
Clinical significance of neutrophil gelatinase-associated lipocalin in Crimean-Congo hemorrhagic Fever. (25685783)
2015
6
Fiber-optic immunosensor for detection of Crimean-Congo hemorrhagic fever IgG antibodies in patients. (26151547)
2015
7
Emergence of Crimean-Congo hemorrhagic fever. (26464230)
2015
8
A novel AP92-like Crimean-Congo hemorrhagic fever virus strain, Greece. (24953797)
2014
9
Prevalence of crimean-congo hemorrhagic Fever virus in healthy population, livestock and ticks in kosovo. (25393542)
2014
10
Serosurvey of Crimean-Congo hemorrhagic fever virus in domestic animals, Gujarat, India, 2013. (25229708)
2014
11
Seroprevalence of Crimean-Congo hemorrhagic fever in southeastern Bulgaria. (25241694)
2014
12
Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011. (23195573)
2013
13
Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever. (24270136)
2013
14
Influence of laboratory animal hosts on the life cycle of Hyalomma marginatum and implications for an in vivo transmission model for Crimean-Congo hemorrhagic fever virus. (23971007)
2013
15
Temporal modeling of Crimean-Congo hemorrhagic fever in eastern Iran. (23474177)
2013
16
Bayesian phylogeography of crimean-congo hemorrhagic Fever virus in europe. (24223988)
2013
17
Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)
2013
18
Comparative study between Ribavirin and Ribavirin plus Intravenous Immunoglobulin against Crimean Congo hemorrhagic fever. (24250699)
2013
19
Factors associated with IgG positivity to Crimean-Congo hemorrhagic fever virus in the area with the highest seroprevalence in Greece. (23831367)
2013
20
Guineafowl, ticks and Crimean-Congo hemorrhagic fever in Turkey: the perfect storm? (23206535)
2013
21
Hepatocyte pathway alterations in response to in vitro Crimean Congo hemorrhagic fever virus infection. (24184319)
2013
22
Bradycardia seen in children with Crimean-Congo hemorrhagic fever. (24107209)
2013
23
Crimean-Congo hemorrhagic fever Asia-2 genotype, Pakistan. (23735999)
2013
24
Relationship between Crimean-Congo hemorrhagic fever virus strains circulating in Iran and Turkey: possibilities for transborder transmission. (22925023)
2012
25
Bradycardia in a patient with Crimean-Congo hemorrhagic fever related to ribavirin treatment. (23135017)
2012
26
Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey. (22192531)
2012
27
Species distribution and detection of Crimean Congo Hemorrhagic Fever Virus (CCHFV) in field-collected ticks in Ankara Province, Central Anatolia, Turkey. (21910017)
2012
28
Crimean-Congo hemorrhagic fever virus in ticks, Southwestern Europe, 2010. (22261502)
2012
29
Effect of oral ribavirin treatment on the viral load and disease progression in Crimean-Congo hemorrhagic fever. (21106428)
2011
30
Species diversity of ixodid ticks feeding on humans in Amasya, Turkey: seasonal abundance and presence of Crimean-Congo hemorrhagic fever virus. (21337953)
2011
31
Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness. (20403306)
2010
32
Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. (20005156)
2010
33
Crimean-Congo hemorrhagic fever in Iran and neighboring countries. (20006541)
2010
34
Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran. (20854025)
2010
35
Ancient common ancestry of Crimean-Congo hemorrhagic fever virus. (20074652)
2010
36
Towards an understanding of the migration of Crimean-Congo hemorrhagic fever virus. (19812264)
2010
37
Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: a case-control study. (19168952)
2009
38
A case of Crimean-congo hemorrhagic fever with pleural effusion. (19168966)
2009
39
Crimean-Congo hemorrhagic fever. (17762783)
2007
40
A variable region in the Crimean-Congo hemorrhagic fever virus L segment distinguishes between strains isolated from different geographic regions. (16372290)
2006
41
Crimean-Congo hemorrhagic fever in Southeast of Iran. (16182370)
2006
42
Recombinant nucleoprotein-based serological diagnosis of Crimean-Congo hemorrhagic fever virus infections. (15602720)
2005
43
Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment. (15033561)
2004
44
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. (12885882)
2003
45
Treatment and prophylaxis with ribavirin for Crimean-Congo Hemorrhagic Fever--is it effective? (12666854)
2003
46
Isolation of Crimean-Congo hemorrhagic fever virus from ticks on imported Sudanese sheep in Saudi Arabia. (17322717)
2000
47
Replication and tissue tropisms of Crimean-Congo hemorrhagic fever virus in experimentally infected adult Hyalomma truncatum (Acari: Ixodidae). (1404255)
1992
48
Distribution of Crimean-Congo hemorrhagic fever viral antibody in Senegal: environmental and vectorial correlates. (2122750)
1990
49
Comparison of methods for isolation and titration of Crimean-Congo hemorrhagic fever virus. (3095367)
1986
50
Crimean-congo hemorrhagic fever, Thogoto, dugbe, and Jos viruses isolated from ixodid ticks in Ethiopia. (98066)
1978

Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 49)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL6, TNF
29.6NFKB1, TNF
39.6NFKB1, TNF
49.5IL6, NFKB1
59.5CASP3, TNF
69.2CXCL10, IL6, TNF
7
Show member pathways
9.2IL6, TLR8, TLR9
8
Show member pathways
9.2IL6, NFKB1, TNF
9
Show member pathways
9.2IL6, NFKB1, TNF
10
Show member pathways
9.2IL6, NFKB1, TNF
119.2IL6, NFKB1, TNF
129.2IL6, NFKB1, TNF
139.2IL6, NFKB1, TNF
149.2IL6, TLR9, TNF
159.2IL6, TLR9, TNF
169.2IL6, TLR9, TNF
17
Show member pathways
9.1NFKB1, TLR8, TLR9
189.0CASP3, NFKB1, TNF
199.0CASP3, NFKB1, TNF
20
Show member pathways
9.0CASP3, NFKB1, TNF
21
Show member pathways
9.0CASP3, NFKB1, TNF
228.9CASP3, IL6, NFKB1
238.9CASP3, IL6, NFKB1
24
Show member pathways
8.9IL6, MX1, TNF
25
Show member pathways
8.8IL6, TLR8, TLR9, TNF
26
Show member pathways
8.7CXCL10, IL6, NFKB1, TNF
278.6IL6, NFKB1, TLR9, TNF
288.6CASP3, CXCL10, IL6, TNF
29
Show member pathways
8.5CASP3, IL6, NFKB1, TNF
30
Show member pathways
8.5CASP3, IL6, NFKB1, TNF
318.5CASP3, IL6, NFKB1, TNF
328.5CASP3, IL6, NFKB1, TNF
338.5CASP3, IL6, NFKB1, TNF
34
Show member pathways
8.5CASP3, IL6, NFKB1, TNF
358.5CASP3, IL6, NFKB1, TNF
36
Show member pathways
8.3IL6, NFKB1, TLR8, TLR9, TNF
378.3CXCL10, NFKB1, TLR8, TLR9, TNF
388.2CASP3, F3, IL6, NFKB1, TNF
398.1CASP3, CXCL10, IL6, NFKB1, TNF
40
Show member pathways
8.1CASP3, CXCL10, IL6, NFKB1, TNF
41
Show member pathways
8.1CASP3, NFKB1, TLR8, TLR9, TNF
428.0CASP3, IL6, NFKB1, TLR9, TNF
43
Show member pathways
8.0F3, IL6, NFKB1, TLR8, TLR9, TNF
44
Show member pathways
7.8CXCL10, IL6, NFKB1, TLR8, TLR9, TNF
457.7CASP3, IL6, NFKB1, TLR8, TLR9, TNF
46
Show member pathways
7.2CASP3, CXCL10, IL6, NFKB1, TLR8, TLR9
47
Show member pathways
7.2CASP3, CXCL10, IL6, NFKB1, TLR8, TLR9
48
Show member pathways
6.9CASP3, IL6, MX1, NFKB1, TLR8, TLR9
49
Show member pathways
6.7CASP3, CXCL10, IL6, MX1, NFKB1, TLR9

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endolysosome membraneGO:00360209.8TLR8, TLR9
2external side of plasma membraneGO:00098979.2CXCL10, IL6, TNF

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:004541610.4TLR8, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4IL6, TNF
3regulation of cytokine secretionGO:005070710.3TLR8, TLR9
4positive regulation of interferon-alpha biosynthetic processGO:004535610.3TLR8, TLR9
5positive regulation of interferon-beta biosynthetic processGO:004535910.3TLR8, TLR9
6toll-like receptor 9 signaling pathwayGO:003416210.3TLR8, TLR9
7negative regulation of lipid storageGO:001088810.3IL6, TNF
8cellular response to nicotineGO:007131610.2NFKB1, TNF
9MyD88-dependent toll-like receptor signaling pathwayGO:000275510.2TLR8, TLR9
10positive regulation of interferon-gamma biosynthetic processGO:004507810.2TLR8, TLR9
11positive regulation of NF-kappaB import into nucleusGO:004234610.2TLR9, TNF
12response to auditory stimulusGO:001099610.2CXCL10, IL6
13negative regulation of interleukin-6 productionGO:003271510.2TLR9, TNF
14toll-like receptor signaling pathwayGO:000222410.2TLR8, TLR9
15positive regulation of JUN kinase activityGO:004350710.1TLR9, TNF
16response to antibioticGO:004667710.0CASP3, IL6
17negative regulation of myoblast differentiationGO:004566210.0CXCL10, TNF
18positive regulation of interleukin-8 productionGO:00327579.9TLR9, TNF
19positive regulation of protein kinase B signalingGO:00518979.9F3, IL6, TNF
20positive regulation of chemokine productionGO:00327229.9IL6, TLR9, TNF
21I-kappaB kinase/NF-kappaB signalingGO:00072499.8NFKB1, TLR8, TNF
22response to glucocorticoidGO:00513849.7CASP3, IL6, TNF
23positive regulation of interleukin-6 productionGO:00327559.5IL6, TLR9, TNF
24activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.5CASP3, F3, TNF
25regulation of cell proliferationGO:00421279.4CXCL10, IL6, TNF
26cellular response to lipopolysaccharideGO:00712229.2CXCL10, IL6, NFKB1, TNF
27positive regulation of NF-kappaB transcription factor activityGO:00510929.0IL6, NFKB1, TLR9, TNF
28response to lipopolysaccharideGO:00324968.8CASP3, CXCL10, F3, IL6
29response to virusGO:00096158.7CXCL10, MX1, TLR8, TNF
30innate immune responseGO:00450878.6MX1, NFKB1, TLR8, TLR9
31defense response to virusGO:00516078.6CXCL10, IL6, MX1, TLR8
32positive regulation of transcription from RNA polymerase II promoterGO:00459448.2CXCL10, IL6, NFKB1, TLR9, TNF
33inflammatory responseGO:00069548.2CXCL10, IL6, NFKB1, TLR8, TLR9, TNF

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.2CASP3, F3, TNF

Sources for Crimean-Congo Hemorrhagic Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet