CCHF
MCID: CRM001
MIFTS: 58

Crimean-Congo Hemorrhagic Fever (CCHF) malady

Infectious category

Summaries for Crimean-Congo Hemorrhagic Fever

Sources:
8Disease Ontology, 3CDC, 33MalaCards
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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, has material basis in crimean-congo hemorrhagic fever virus, which is transmitted by hyalomma ticks. the infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards: Crimean-Congo Hemorrhagic Fever, also known as crimean hemorrhagic fever, is related to thrombocytopenia and hemorrhagic fever, and has symptoms including nausea/vomiting/regurgitation/merycism/hyperemesis, collapse/sudden death/cardiac arrest/cardiorespiratory arrest and early death/lethality. An important gene associated with Crimean-Congo Hemorrhagic Fever is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Leishmaniasis and Legionellosis. The compounds cycloheximide and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include heart, monocytes and endothelial, and related mouse phenotypes are respiratory system and muscle.

CDC:3 Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was first characterized in the Crimea in 1944 and given the name Crimean hemorrhagic fever. It was then later recognized in 1969 as the cause of illness in the Congo, thus resulting in the current name of the disease.

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
crimean-congo hemorrhagic fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

crimean-congo hemorrhagic fever 8 10 49
crimean hemorrhagic fever 8 49
congo hemorrhagic fever 49 61
congo-crimean hemorrhagic fever 8
hemorrhagic fever crimean-congo 45
hemorrhagic fever, crimean 61
chf congo virus 8
congo fever 49
cchf 49


External Ids:

Disease Ontology8 DOID:12287
MeSH35 D006479
NCIt40 C34682
ICD9CM27 065.0
SNOMED-CT57 43489008
ICD10 via Orphanet26 A98.0
SNOMED-CT via Orphanet58 43489008
ICD1025 A98.0

Related Diseases for Crimean-Congo Hemorrhagic Fever

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Clinical Features for Crimean-Congo Hemorrhagic Fever

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 37)
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • early death/lethality
  • asthenia/fatigue/weakness
  • fever/chilling
  • hepatitis/icterus/cholestasis
  • cutaneous rash
  • thoracic/chest pain
  • cough
  • myalgia/muscular pain
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • gingivorrhagia/gingival bleeding
  • thrombocytopenia/thrombopenia
  • facial pain/cephalalgia/migraine
  • purpura/petichiae
  • abnormal hepatic enzymes/transaminases
  • pharyngitis
  • epistaxis/nose bleeding
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • acute diarrhea
  • leukopenia/hypoleukocytosis
  • liver/hepatic steatosis
  • headache
  • jaundice
  • vomiting
  • joint pain
  • nosebleeds
  • back pain
  • stomach pain
  • red eyes
  • high fever
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • blood in the feces

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Crimean-Congo Hemorrhagic Fever

Drug clinical trials:

Search ClinicalTrials for Crimean-Congo Hemorrhagic Fever

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Search CenterWatch for Crimean-Congo Hemorrhagic Fever

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

33
Heart, Monocytes, Endothelial

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Crimean-Congo Hemorrhagic Fever

Sources:
51PubMed
See all sources

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
Seroprevalence and risk factors of Crimean-Congo hemorrhagic fever in selected seven provinces in Turkey. (24037814)
2014
2
Resting heart rate in children with crimean-congo hemorrhagic Fever: a tool to identify patients at risk? (24359422)
2014
3
Emergence of Crimean-Congo hemorrhagic fever in Amreli District of Gujarat State, India, June to July 2013. (24211848)
2014
4
Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011. (23195573)
2013
5
Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever. (24270136)
2013
6
Evaluation of the relationship between serum levels of VEGF and sVEGFR1 with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. (23868816)
2013
7
Pathogenesis of crimean-congo hemorrhagic Fever. (23663164)
2013
8
Application of the pseudo-plaque assay for detection and titration of Crimean-Congo hemorrhagic fever virus. (22906394)
2013
9
Development and evaluation of loop-mediated isothermal amplification assay for detection of Crimean Congo hemorrhagic fever virus in Sudan. (23542058)
2013
10
Crimean-Congo hemorrhagic fever virus in various ixodid tick species from a highly endemic area. (22119389)
2012
11
C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever. (22695238)
2012
12
Species distribution and detection of Crimean Congo Hemorrhagic Fever Virus (CCHFV) in field-collected ticks in Ankara Province, Central Anatolia, Turkey. (21910017)
2012
13
Possible drivers of Crimean-Congo hemorrhagic fever virus transmission in Kosova. (22217174)
2012
14
Serosurvey and molecular detection of Crimean-Congo hemorrhagic fever virus (CCHFV) in northern Turkey. (22457191)
2012
15
Evaluation of factors predictive of the prognosis in Crimean-Congo hemorrhagic fever: new suggestions. (22154082)
2012
16
Seroepidemiological survey of Crimean-Congo hemorrhagic fever among sheep in Mazandaran province, northern Iran. (22917135)
2012
17
Subclinical infections with Crimean-Congo hemorrhagic fever virus, Turkey. (22469474)
2012
18
Structural characterization of the Crimean-Congo hemorrhagic fever virus Gn tail provides insight into virus assembly. (21507948)
2011
19
Epitope-based immunoinformatics and molecular docking studies of nucleocapsid protein and ovarian tumor domain of crimean-congo hemorrhagic Fever virus. (22303367)
2011
20
Crimean-Congo hemorrhagic fever virus activates endothelial cells. (21632768)
2011
21
Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran. (20854025)
2010
22
Ancient common ancestry of Crimean-Congo hemorrhagic fever virus. (20074652)
2010
23
Knowledge levels about Crimean-Congo hemorrhagic fever among midwifery and nursing students in Kahramanmaras, Turkey. (20578485)
2010
24
Molecular epidemiology of Crimean- Congo hemorrhagic fever virus genome isolated from ticks of Hamadan province of Iran. (21178213)
2010
25
Comparison of antiviral activity of recombinant and natural interferons against crimean-congo hemorrhagic Fever virus. (20517491)
2010
26
A Simple-Probe real-time PCR assay for genotyping reassorted and non-reassorted isolates of Crimean-Congo hemorrhagic fever virus in southern Africa. (20599559)
2010
27
Crimean-Congo hemorrhagic fever virus entry and replication is clathrin-, pH- and cholesterol-dependent. (19088291)
2009
28
DEBATE (see Elaldi N et al, Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: a quasi-experimental study from Turkey. Journal of Infection 2009; 58: 238-244): Biases and misinterpretation in the assessment of the efficacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever. (19699762)
2009
29
Two Crimean-Congo hemorrhagic fever cases without history of tick contact from Ankara region]. (20084924)
2009
30
Crimean Congo hemorrhagic fever virus infects human monocyte-derived dendritic cells. (19570561)
2009
31
The epidemiology of Crimean-Congo hemorrhagic fever in Turkey, 2002-2007. (18986819)
2009
32
Crimean-Congo hemorrhagic fever in Pakistan. (18428123)
2008
33
Treatment of Crimean-Congo hemorrhagic fever. (18096251)
2008
34
Modeling the spatial distribution of crimean-congo hemorrhagic fever outbreaks in Turkey. (18047397)
2007
35
Crimean-Congo hemorrhagic fever. (17762783)
2007
36
Development of a TaqMan minor groove binding protein assay for the detection and quantification of Crimean-Congo hemorrhagic fever virus. (17827370)
2007
37
Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo hemorrhagic fever virus. (16298979)
2005
38
A simple assay for determining antiviral activity against Crimean-Congo hemorrhagic fever virus. (15026198)
2004
39
Reverse genetics for crimean-congo hemorrhagic fever virus. (12719591)
2003
40
Genetic characterization of the M RNA segment of Crimean Congo hemorrhagic fever virus strains, China. (11749748)
2002
41
Characterization of the glycoproteins of Crimean-Congo hemorrhagic fever virus. (12072526)
2002
42
Genetic diversity of the M RNA segment among Crimean-Congo hemorrhagic fever virus isolates in China. (12036327)
2002
43
Crimean-Congo hemorrhagic fever]. (11521472)
2000
44
An outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates, 1994-1995. (9392589)
1997
45
Risk of human infections with Crimean-Congo hemorrhagic fever virus in a South African rural community. (1524147)
1992
46
Viremia and antibody response of small African and laboratory animals to Crimean-Congo hemorrhagic fever virus infection. (2499205)
1989
47
Experimental transmission of Crimean-Congo hemorrhagic fever virus by Hyalomma truncatum Koch. (2493203)
1989
48
Crimean-congo hemorrhagic fever in South Africa. (6418019)
1983
49
The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. (113533)
1979
50
Results of a preliminary seroepidemiological survey for Crimean-Congo hemorrhagic fever virus in Egypt. (25013)
1978

Genetic Variations for Crimean-Congo Hemorrhagic Fever

Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 54Reactome, 53R&D Systems
See all sources

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3NFKB1
210.1NFKB1, CASP3
39.9IL6, NFKB1, CASP3
4
Hide members
9.8NFKB1, TNF, CASP3
5
Immune response Bacterial infections in normal airways
9.8TNF, NFKB1, IL6
69.8IL6, NFKB1, TNF
79.8TNF, NFKB1, IL6
89.8TNF, NFKB1, IL6
9
Hide members
9.8IL6, NFKB1, TNF
109.8TLR8, NFKB1, IL6
11
Hide members
9.8TLR8, TNF, IL6
12
Hide members
9.8TLR8, TNF, IL6
13
Hide members
9.7NFKB1, TNFRSF19, CASP3
14
Development PDGF signaling via STATs and NF-kB
Hide members
9.7F2, IL6, NFKB1, TNF
159.7TNF, NFKB1, IL6, F2
16
Hide members
9.6F3, IL6, NFKB1, TNF
179.6IL6, NFKB1, TNF, CASP3
18
Hide members
9.6CASP3, TNF, NFKB1, IL6
199.6CASP3, TNF, NFKB1, IL6
209.6CASP3, TNF, NFKB1, IL6
219.6IL6, NFKB1, TNF, CASP3
22
Hide members
9.6ISG20, NFKB1, IL6, MX1
239.6NFKB1, VEGFA, TNF, CASP3
24
Hide members
9.6TLR8, TNF, NFKB1, IL6
25
Hide members
9.5CASP3, TNF, NFKB1, IL6, MX1
269.4CASP3, TNF, VEGFA, NFKB1, IL6
279.4CASP3, TLR8, TNF, NFKB1, IL6
28
Hide members
9.4CASP3, TLR8, TNF, NFKB1, IL6
29
Hide members
9.2NFKB1, TNF, TNFRSF19, TLR8, CASP3

Compounds for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6MX1
2prednisolone45 29 1112.5SLC17A5
3aprotinin45 1111.5SLC17A5, F3
4pdtc4510.5IL6, F3
5aprosulate4510.4F3, F2
6brodifacoum4510.4F2, F3
7napsagatran4510.4F2, F3
8ximelagatran45 1111.4GPT, F2, F3
9troglitazone45 29 60 1113.3GPT, SLC17A5, CASP3
10aminopyrine4510.3SLC17A5, GPT, F2
11hemochron4510.3F2, F3
12certoparin4510.3F3, F2
13gm-csf45 2911.3TNF
14d-galactosamine4510.3GPT, TNF, SLC17A5
15appt4510.3F2, F3
16lamivudine45 1111.2F2, SLC17A5
17hepaplastin4510.2SLC17A5, GPT, F3, F2
18levonorgestrel45 60 29 1113.2F3, F2, SLC17A5
19nash4510.2TNF, CHIT1, SLC17A5, GPT
20tpck4510.2IL6, CASP3, TNF
21silymarin4510.1SLC17A5, GPT, F2, VEGFA
22cyclosporin a45 29 6012.1GPT, F2, RNPC3, SLC17A5
23pge14510.1IL6, GPT, SLC17A5, F2
24zoledronic acid4510.1IL6, VEGFA, CASP3
25ribavirin45 50 1112.1ISG20, MX1, SLC17A5, GPT
26fenofibrate45 50 1112.1TNF, IL6, GPT, SLC17A5
27protamine4510.0RNPC3, F2, F3, IL6
28imiquimod45 29 60 1113.0TNF, MX1, IL6, TLR8
29triptolide4510.0TNF, IL6, CASP3, VEGFA
30poly(i-c)4510.0TLR8, IL6, MX1, TNF
31aebsf4510.0F3, TNF, MBTPS1, CASP3
3215-deoxy-delta-12,14-prostaglandin j24510.0VEGFA, CASP3, IL6, TNF
33sp 60012545 6011.0CASP3, TNF, IL6, F3
34thalidomide45 50 60 1113.0IL6, VEGFA, TNF, NFKB1
35rosuvastatin45 50 29 1112.9IL6, GPT, SLC17A5
36rosiglitazone45 50 29 11 2413.9IL6, SLC17A5, GPT, TNF
37pioglitazone45 50 29 1112.9GPT, IL6, VEGFA, TNF, SLC17A5
38methotrexate45 50 1111.9TNF, SLC17A5, F2, GPT, IL6
39atorvastatin45 50 29 11 2413.9SLC17A5, GPT, VEGFA, TNF, IL6
402,5-oligoadenylate459.9GPT, MX1, TNF, ISG20, IL6
41neopterin459.8SLC17A5, MX1, GPT, IL6, CHIT1, TNF
42sb 20358045 6010.8CASP3, TNF, VEGFA, F3, IL6
43parthenolide45 210.7CASP3, IL6, TNF
44lactate459.7SLC17A5, F2, IL6, GPT, CASP3, TNF
45fibrinogen459.6GPT, F3, IL6, CHIT1, SLC17A5, TNF
46hyaluronic acid45 2410.5SLC17A5, GPT, IL6, VEGFA, STAB2, F2
47ciglitazone45 2910.5TNF, CASP3, IL6
48n acetylcysteine459.5CASP3, TNF, IL6, GPT, F2, SLC17A5
49actinomycin d459.4TNF, VEGFA, IL6, F3, CASP3
50simvastatin45 50 60 29 11 2414.4TNF, GPT, VEGFA, IL6, F3, CASP3

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.3F2, F3, IL6, VEGFA, CHIT1, TNF

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.1IL6, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1IL6, TNF
3negative regulation of viral genome replicationGO:04507110.0TNF, ISG20, MX1
4positive regulation of peptidyl-serine phosphorylationGO:03313810.0TNF, VEGFA, IL6
5positive regulation of interleukin-8 biosynthetic processGO:0454169.9TNF, TLR8
6positive regulation of protein phosphorylationGO:0019349.8F2, VEGFA, TNF
7positive regulation of protein kinase B signaling cascadeGO:0518979.8TNF, IL6, F3
8positive regulation of positive chemotaxisGO:0509279.8F3, VEGFA
9response to virusGO:0096159.8MX1, ISG20, TNF, TLR8
10defense response to virusGO:0516079.7MX1, IL6, ISG20, TLR8
11regulation of cell shapeGO:0083609.7PARVA, F2, IL6, VEGFA

Products for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources for Crimean-Congo Hemorrhagic Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet