MCID: CRM001
MIFTS: 54

Crimean-Congo Hemorrhagic Fever malady

Categories: Genetic diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 45NCIt, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 11 54 2 13
Hemorrhagic Fever, Crimean 39 68
Crimean Hemorrhagic Fever 11 54
Congo Hemorrhagic Fever 54 68
Cchf 54 2
 
Congo-Crimean Hemorrhagic Fever 11
Hemorrhagic Fever Crimean-Congo 50
Chf Congo Virus 11
Congo Fever 54

Characteristics:

Orphanet epidemiological data:

54
crimean-congo hemorrhagic fever:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:12287
ICD1030 A98.0
ICD9CM32 065.0
MeSH39 D006479
SNOMED-CT62 43489008
NCIt45 C34682
Orphanet54 ORPHA99827
ICD10 via Orphanet31 A98.0

Summaries for Crimean-Congo Hemorrhagic Fever

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Disease Ontology:11 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to hemophagocytic lymphohistiocytosis and malaria, and has symptoms including abnormality of temperature regulation, skin rash and hepatic steatosis. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways are Cytokines and Inflammatory Response and African trypanosomiasis. Affiliated tissues include eye, skin and testes, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Related Diseases for Crimean-Congo Hemorrhagic Fever

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Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1hemophagocytic lymphohistiocytosis30.5IL6, TNF
2malaria28.5CXCL10, F3, IL6, TNF, VEGFA
3hemorrhagic fever11.4
4idiopathic central precocious puberty10.4F3, TNF
5chronic diarrhea due to guanylate cyclase 2c overactivity10.4F3, IL6
6panner disease10.4IL6, TNF
7aortic arch interruption10.4IL6, TNF
8maligant granulosa cell tumor of ovary10.4IL6, TNF
9hemometra10.4IL6, TNF
10tricho odonto onycho dermal syndrome10.4IL6, TNF
11scrotum paget's disease10.4IL6, TNF
12epstein-barr virus hepatitis10.4IL6, TNF
13abdominal chemodectomas with cutaneous angiolipomas10.4IL6, TNF
14antigen-peptide-transporter 2 deficiency10.4IL6, TNF
15hypothyroidism10.4IL6, TNF
16ethmoid sinus adenoid cystic carcinoma10.4IL6, TNF
17splenic manifestation of prolymphocytic leukemia10.4IL6, TNF
18post-infectious myocarditis10.4IL6, TNF
19skin disease10.4IL6, TNF
20pasteurellosis10.4IL6, TNF
21scarlet fever10.4IL6, TNF
22lymphocytic colitis10.4IL6, TNF
23non-secretory myeloma10.4IL6, TNF
24idiopathic neutropenia10.4F3, IL6
25tonsillar fossa cancer10.4CASP3, IL6
26sweat gland cancer10.4F3, IL6
27qualitative platelet defect10.4IL6, TNF
28sterility due to immotile flagella10.4IL6, TNF
29islet cell tumor10.4IL6, TNF
30rift valley fever10.4
31ulcerative colitis10.4CASP3, IL6
32orbital lymphangioma10.4IL6, TNF
33cauda equina syndrome10.4IL6, TNF
34renal cell carcinoma 410.4IL6, TNF
35nondystrophic myotonia10.4GPT, TNF
36paraneoplastic polyneuropathy10.3IL6, TNF
37thoracic aortic aneurysm10.3IL6, TNF
38steatorrhea10.3CXCL10, TNF
39epididymis adenomatoid tumor10.3IL6, TNF
40primary biliary cirrhosis10.3IL6, TNF
41colon carcinoma in situ10.3F3, IL6
42ampulla of vater neoplasm10.3IL6, TNF
43leukostasis10.3IL6, TNF
44mechanical lagophthalmos10.3IL6, TNF
45oral candidiasis10.3IL6, TNF
46foodborne botulism10.3IL6, TNF
47psychologic dyspareunia10.3CXCL10, TNF
48gastroduodenal crohn's disease10.3IL6, TNF
49substernal goiter10.3CXCL10, IL6
50endotheliitis10.3

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

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Symptoms:

 11 (show all 13)
  • headache
  • high fever
  • back pain
  • joint pain
  • stomach pain
  • vomiting
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • jaundice
  • nosebleeds
  • blood in the feces

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

 64 54 (show all 29)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of temperature regulation64 hallmark (90%) HP:0004370
2 skin rash64 54 typical (50%) Frequent (79-30%) HP:0000988
3 hepatic steatosis64 54 typical (50%) Frequent (79-30%) HP:0001397
4 subcutaneous hemorrhage64 typical (50%) HP:0001933
5 diarrhea64 54 typical (50%) Frequent (79-30%) HP:0002014
6 nausea and vomiting64 54 typical (50%) Frequent (79-30%) HP:0002017
7 abdominal pain64 54 typical (50%) Frequent (79-30%) HP:0002027
8 migraine64 typical (50%) HP:0002076
9 elevated hepatic transaminases64 54 typical (50%) Frequent (79-30%) HP:0002910
10 myalgia64 54 typical (50%) Frequent (79-30%) HP:0003326
11 inflammatory abnormality of the eye64 typical (50%) HP:0100533
12 recurrent pharyngitis64 54 typical (50%) Frequent (79-30%) HP:0100776
13 gingival bleeding64 54 occasional (7.5%) Occasional (29-5%) HP:0000225
14 epistaxis64 54 occasional (7.5%) Occasional (29-5%) HP:0000421
15 sudden cardiac death64 occasional (7.5%) HP:0001645
16 thrombocytopenia64 54 occasional (7.5%) Occasional (29-5%) HP:0001873
17 leukopenia64 54 occasional (7.5%) Occasional (29-5%) HP:0001882
18 abnormality of coagulation64 occasional (7.5%) HP:0001928
19 gastrointestinal hemorrhage64 54 occasional (7.5%) Occasional (29-5%) HP:0002239
20 chest pain64 54 occasional (7.5%) Occasional (29-5%) HP:0100749
21 uveitis54 Frequent (79-30%)
22 jaundice54 Occasional (29-5%)
23 petechiae54 Frequent (79-30%)
24 abnormal bleeding54 Occasional (29-5%)
25 fever54 Very frequent (99-80%)
26 headache54 Frequent (79-30%)
27 cardiorespiratory arrest54 Occasional (29-5%)
28 fatigue54 Very frequent (99-80%)
29 cough54 Frequent (79-30%)

UMLS symptoms related to Crimean-Congo Hemorrhagic Fever:


hemoptysis, cullen's sign, traumatic hematuria, mucosal haemorrhage, nail bed hemorrhage

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6CASP3, IL6, NFKB1, TNF, VEGFA
2MP:00053858.4CASP3, CXCL10, F3, IL6, TNF, VEGFA
3MP:00107718.2CASP3, F3, IL6, NFKB1, TNF, VEGFA
4MP:00053698.2CASP3, F3, IL6, NFKB1, TNF, VEGFA
5MP:00053847.8CASP3, CXCL10, F3, IL6, NFKB1, TNF
6MP:00053887.8CASP3, IL6, NFKB1, TNF, VEGFA
7MP:00036317.7CASP3, CXCL10, F3, IL6, NFKB1, TNF
8MP:00053767.4CASP3, CXCL10, F3, IL6, NFKB1, TLR8
9MP:00053877.4CASP3, CXCL10, F3, IL6, NFKB1, TLR8
10MP:00053976.9CASP3, CXCL10, F3, GPT, IL6, NFKB1

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 298436791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2AntimetabolitesPhase 211774
3Anti-Infective AgentsPhase 221402
4Antiviral AgentsPhase 29732
5
Formaldehydeapproved, vet_approvedPhase 18450-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalin
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
6VaccinesPhase 16428
7Pharmaceutical SolutionsPhase 17793

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for HumansActive, not recruitingNCT03020771Phase 1
3Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
4Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverNot yet recruitingNCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever


Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

36
Eye, Skin, Testes, Endothelial, Heart, Neutrophil

Publications for Crimean-Congo Hemorrhagic Fever

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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Crimean-Congo hemorrhagic fever among children in Iran. (27878461)
2016
2
Does Crimean-Congo Hemorrhagic Fever Cause a Vasculitic Reaction with Pulmonary Artery Enlargement and Acute Pulmonary Hypertension? (27344326)
2016
3
Crimean-Congo Hemorrhagic Fever in Dubai, United Arab Emirates, 2010: Case Report. (27795839)
2016
4
Possible sexual transmission of Crimean-Congo hemorrhagic fever. (26972040)
2016
5
Crimean-Congo hemorrhagic fever - A ticking bomb? (27044612)
2016
6
Crimean-Congo hemorrhagic fever virus lineages Europe 1 and Europe 2 in Bulgarian ticks. (27378409)
2016
7
Current situation of Crimean-Congo hemorrhagic fever in Southeastern Europe and neighboring countries: a public health risk for the European Union? (27044611)
2016
8
The first fatal case of Crimean-Congo Hemorrhagic Fever due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus. (26902209)
2016
9
Crimean-Congo Hemorrhagic Fever Knowledge, Attitudes, Practices, Risk Factors, and Seroprevalence in Rural Georgian Villages with Known Transmission in 2014. (27336731)
2016
10
Crimean-Congo Hemorrhagic Fever Virus IgG in Goats, Bhutan. (27088568)
2016
11
Serum sTREM-1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection. (26877157)
2016
12
Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran. (27308275)
2016
13
Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. (27353580)
2016
14
Molecular Assay on Crimean Congo Hemorrhagic Fever Virus in Ticks (Ixodidae) Collected from Kermanshah Province, Western Iran. (27308296)
2016
15
A child with an unusual complication of Crimean-Congo hemorrhagic fever: Hemorrhagic pleural effusion. (27004585)
2016
16
Examination of the specific clinical symptoms and laboratory findings of Crimean-Congo hemorrhagic fever. (27353587)
2016
17
Heat Shock Protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle. (27512070)
2016
18
Determination of nasal mucociliary clearance time and nasal symptom in patients with crimean-congo hemorrhagic fever. (27813123)
2016
19
Biosafety standards for working with Crimean-Congo hemorrhagic fever virus. (27667586)
2016
20
Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana. (27392037)
2016
21
Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system. (26935918)
2016
22
Crimean-Congo Hemorrhagic Fever with Acute Subdural Hematoma, Mauritania, 2012. (27315138)
2016
23
Sero-epidemiological survey of Crimean-Congo hemorrhagic fever virus in Tunisia. (26956221)
2016
24
The prognostic significance of serum TGF-I^1 levels in patients with Crimean-Congo hemorrhagic fever. (27467498)
2016
25
Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever. (27378224)
2016
26
Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity. (27775001)
2016
27
Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. (27666016)
2016
28
Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area. (27677379)
2016
29
Crimean-Congo hemorrhagic fever with hyperbilirubinemia and ascites: An unusual presentation. (26129885)
2016
30
Novel, In-House, SYBR Green Based One-Step rRT-PCR: Rapid and Accurate Diagnosis of Crimean-Congo Hemorrhagic Fever Virus in Suspected Patients From Iran. (27099688)
2016
31
Molecular analysis of Crimean-Congo hemorrhagic fever virus and Rickettsia in Hyalomma marginatum ticks removed from patients (Spain) and birds (Spain and Morocco), 2009-2015. (27215620)
2016
32
A retrospective controlled study of thiol disulfide homeostasis as a novel marker in Crimean Congo hemorrhagic fever. (27159644)
2016
33
Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. (27110812)
2016
34
The prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever. (27089100)
2016
35
Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses. (27217069)
2016
36
Clinical severity in forecasting platelet to lymphocyte ratio in Crimean-Congo hemorrhagic fever patients. (27501696)
2016
37
Molecular epidemiology of Crimean-Congo hemorrhagic fever virus detected from ticks of one humped camels (Camelus dromedarius) population in northeastern Iran. (27065608)
2016
38
Multi-center prospective evaluation of discharge criteria for hospitalized patients with Crimean-Congo Hemorrhagic Fever. (27424492)
2016
39
Epidemiological Survey of Crimean-Congo Hemorrhagic Fever (CCHF), a Fatal Infectious Disease in Khuzestan Province, Southwest Iran, During 1999 - 2015. (27540454)
2016
40
Crimean-Congo Hemorrhagic Fever Virus in Bulgaria and Turkey. (27467142)
2016
41
Phylogeography of Crimean Congo Hemorrhagic Fever Virus. (27880794)
2016
42
A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus. (27713073)
2016
43
Protective role of host aquaporin 6 against Hazara virus, a model for Crimean-Congo hemorrhagic fever virus infection. (26976854)
2016
44
A competitive ELISA for species-independent detection of Crimean-Congo hemorrhagic fever virus specific antibodies. (27623345)
2016
45
Phylogeny of tick-derived Crimean-Congo hemorrhagic fever virus strains in Iran. (27491289)
2016
46
PRESEPSIN LEVELS OF PATIENTS WITH CRIMEAN-CONGO HEMORRHAGIC FEVER. (27000451)
2016
47
Thorax CT findings in patients with Crimean-Congo hemorrhagic fever (CCHF). (27818861)
2016
48
Crimean Congo Hemorrhagic Fever Virus and Alkhurma (Alkhumra) Virus in Ticks in Djibouti. (27508862)
2016
49
Seroprevalence of Crimean-Congo hemorrhagic fever in Turkey's Van Province. (27169950)
2016
50
MicroRNA expression profiles in patients with acute Crimean Congo Hemorrhagic Fever reveal possible adjustments to cellular pathways. (27551771)
2016

Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL6, TNF
29.7IL6, TNF
39.6NFKB1, TNF
49.6NFKB1, TNF
59.5IL6, NFKB1
69.5CASP3, TNF
7
Show member pathways
9.3IL6, TLR8, TNF
89.3CXCL10, IL6, TNF
9
Show member pathways
9.2IL6, NFKB1, TNF
109.2IL6, NFKB1, TNF
11
Show member pathways
9.2IL6, NFKB1, TNF
129.2IL6, NFKB1, TNF
139.2IL6, NFKB1, TNF
149.2IL6, NFKB1, TNF
15
Show member pathways
9.0CASP3, NFKB1, TNF
16
Show member pathways
9.0CASP3, NFKB1, TNF
178.9CASP3, IL6, NFKB1
188.9IL6, TNF, VEGFA
19
Show member pathways
8.8IL6, NFKB1, TLR8, TNF
208.8CXCL10, NFKB1, TLR8, TNF
21
Show member pathways
8.7CXCL10, IL6, NFKB1, TNF
228.7IL6, NFKB1, VEGFA
238.7CASP3, TNF, VEGFA
248.6CASP3, CXCL10, IL6, TNF
25
Show member pathways
8.6CASP3, IL6, NFKB1, TNF
268.6CASP3, IL6, NFKB1, TNF
278.6CASP3, IL6, NFKB1, TNF
288.6CASP3, IL6, NFKB1, TNF
298.6CASP3, IL6, NFKB1, TNF
308.5CASP3, NFKB1, VEGFA
31
Show member pathways
8.5F3, IL6, NFKB1, TLR8, TNF
32
Show member pathways
8.4CXCL10, IL6, NFKB1, TLR8, TNF
338.2CASP3, NFKB1, TNF, VEGFA
34
Show member pathways
8.1CASP3, CXCL10, IL6, NFKB1, TNF
35
Show member pathways
8.1CASP3, CXCL10, IL6, NFKB1, TNF
368.1CASP3, CXCL10, IL6, NFKB1, TNF
378.1CASP3, IL6, NFKB1, VEGFA
38
Show member pathways
7.8CASP3, NFKB1, TLR8, TNF, VEGFA
397.8CASP3, IL6, NFKB1, TNF, VEGFA
40
Show member pathways
7.7CASP3, CXCL10, IL6, NFKB1, TLR8, TNF
41
Show member pathways
7.7CASP3, CXCL10, IL6, NFKB1, TLR8, TNF
427.4CASP3, F3, IL6, NFKB1, TNF, VEGFA
437.4CASP3, IL6, NFKB1, TLR8, TNF, VEGFA
44
Show member pathways
7.3CASP3, CXCL10, IL6, NFKB1, TNF, VEGFA

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:000989710.0CXCL10, IL6, TNF
2extracellular spaceGO:00056157.6CXCL10, F3, GPT, IL6, TNF, VEGFA

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:004541610.5TLR8, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.5IL6, TNF
3negative regulation of lipid storageGO:001088810.5IL6, TNF
4positive regulation of chemokine productionGO:003272210.5IL6, TNF
5negative regulation of myoblast differentiationGO:004566210.4CXCL10, TNF
6cellular response to nicotineGO:007131610.4NFKB1, TNF
7response to auditory stimulusGO:001099610.2CXCL10, IL6
8positive regulation of protein kinase B signalingGO:005189710.1F3, IL6, TNF
9response to antibioticGO:004667710.1CASP3, IL6
10positive regulation of positive chemotaxisGO:005092710.1F3, VEGFA
11positive regulation of protein complex assemblyGO:003133410.0TNF, VEGFA
12defense response to virusGO:005160710.0CXCL10, IL6, TLR8
13I-kappaB kinase/NF-kappaB signalingGO:000724910.0NFKB1, TLR8, TNF
14activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.0CASP3, F3, TNF
15positive regulation of NF-kappaB transcription factor activityGO:00510929.9IL6, NFKB1, TNF
16regulation of cell proliferationGO:00421279.9CXCL10, IL6, TNF
17response to glucocorticoidGO:00513849.7CASP3, IL6, TNF
18positive regulation of peptidyl-serine phosphorylationGO:00331389.6IL6, TNF, VEGFA
19positive regulation of cell migrationGO:00303359.6CXCL10, F3, VEGFA
20cellular response to lipopolysaccharideGO:00712229.5CXCL10, IL6, NFKB1, TNF
21response to virusGO:00096159.3CXCL10, TLR8, TNF
22response to lipopolysaccharideGO:00324969.2CASP3, CXCL10, F3, IL6
23inflammatory responseGO:00069549.1CXCL10, IL6, NFKB1, TLR8, TNF
24negative regulation of apoptotic processGO:00430668.8CASP3, IL6, NFKB1, VEGFA
25positive regulation of transcription from RNA polymerase II promoterGO:00459448.6CXCL10, IL6, NFKB1, TNF, VEGFA

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.4IL6, TNF, VEGFA
2protease bindingGO:00020209.2CASP3, F3, TNF

Sources for Crimean-Congo Hemorrhagic Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet