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CCHF
MCID: CRM001

Crimean-congo Hemorrhagic Fever (CCHF) malady
37 symptoms, 20 genes, 190 related diseases, clinical trials.

Summaries for Crimean-congo Hemorrhagic Fever

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8Disease Ontology, 29MalaCards
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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, has material basis in crimean-congo hemorrhagic fever virus, which is transmitted by hyalomma ticks. the infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards: Crimean-congo Hemorrhagic Fever, also known as crimean hemorrhagic fever, is related to hemorrhagic fever with renal syndrome and rubella, and has symptoms including early death/lethality, nausea/vomiting/regurgitation/merycism/hyperemesis and asthenia/fatigue/weakness. An important gene associated with Crimean-congo Hemorrhagic Fever is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Immune response_Bacterial infections in normal airways and IL-10 Pathway. The compounds pdtc and d-galactosamine have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and respiratory system.

Aliases & Classifications for Crimean-congo Hemorrhagic Fever

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8Disease Ontology, 10DISEASES, 41Novoseek, 45Orphanet, 56UMLS, 52SNOMED-CT, 31MeSH, 25ICD9CM, 36NCIt, 24ICD10 via Orphanet, 53SNOMED-CT via Orphanet, 23ICD10
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Aliases & Descriptions:

crimean-congo hemorrhagic fever 8 10 45
crimean hemorrhagic fever 8 45
congo-crimean hemorrhagic fever 8
hemorrhagic fever crimean-congo 41
hemorrhagic fever, crimean 56
hemorrhagic fevers, viral 56
congo hemorrhagic fever 45
chf congo virus 8
congo fever 45
cchf 45

Classifications:


ICD10: 24 23


External Ids:

Disease Ontology8 DOID:12287
ICD9CM25 065.0
SNOMED-CT52 43489008
ICD10 via Orphanet24 A98.0
SNOMED-CT via Orphanet53 43489008
ICD1023 A98.0

Related Diseases for Crimean-congo Hemorrhagic Fever

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16GeneCards, 17GeneDecks
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Diseases related to crimean-congo hemorrhagic fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever with renal syndrome31.2RNPC3
2rubella13.9RNPC3
3nephritis13.8RNPC3
4chondrosarcoma13.8ISG20
5encephalitis13.8MX1
6dementia13.8CHIT1
7filariasis13.8CHIT1
8polymyositis13.8RNPC3
9thalassemia13.8CHIT1
10lichen planus13.8MX1
11dermatomyositis13.8MX1
12acute myocardial infarction13.8F3
13myocardial infarction13.8F3
14hepatitis a13.8F2
15subacute sclerosing panencephalitis13.8MX1
16respiratory failure13.8F3
17down syndrome13.8MX1
18rift valley fever13.8MX1
19familial atrial fibrillation13.8F2
20cerebral infarction13.8F3
21gaucher's disease13.7CHIT1
22kawasaki disease13.7GPT
23sjogren's syndrome13.7RNPC3
24cryoglobulinemia13.7SLC17A5
25hyperthyroidism13.7SLC17A5
26chronic lymphocytic leukemia13.7IGHV4-39
27hepatitis e13.7GPT
28cholecystitis13.7GPT
29fatty liver disease13.7IL6
30neutropenia13.7GPT
31cystic fibrosis13.7IL6
32mixed connective tissue disease13.7RNPC3
33meningitis13.7IL6
34tetanus13.7IL6
35glucose intolerance13.6GPT
36carney complex13.6IL6
37fabry disease13.6CHIT1
38herpes simplex13.6ISG20, MX1
39factor xii deficiency13.6F3
40coronary heart disease13.6IL6
41human immunodeficiency virus infectious disease13.6IL6
42measles13.6RNPC3, MX1
43brucellosis13.6STAB2
44retinal vein occlusion13.6VEGFA
45ovarian hyperstimulation syndrome13.6VEGFA
46lyme disease13.6STAB2
47polyneuropathy13.6VEGFA
48skin disease13.6IL6
49blindness13.6VEGFA
50diabetic retinopathy13.6VEGFA

Graphical network of the top 20 diseases related to crimean-congo hemorrhagic fever:



Diseases related to crimean-congo hemorrhagic fever

Symptoms for Crimean-congo Hemorrhagic Fever

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45Orphanet
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Symptoms:

45
  • early death/lethality
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • asthenia/fatigue/weakness
  • fever/chilling
  • hepatitis/icterus/cholestasis
  • cutaneous rash
  • thoracic/chest pain
  • cough
  • myalgia/muscular pain
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • gingivorrhagia/gingival bleeding
  • thrombocytopenia/thrombopenia
  • facial pain/cephalalgia/migraine
  • purpura/petichiae
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • abnormal hepatic enzymes/transaminases
  • pharyngitis
  • epistaxis/nose bleeding
  • acute diarrhea
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • leukopenia/hypoleukocytosis
  • liver/hepatic steatosis
  • headache
  • vomiting
  • back pain
  • joint pain
  • jaundice
  • nosebleeds
  • stomach pain
  • red eyes
  • high fever
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • blood in the feces

Drugs & Therapeutics for Crimean-congo Hemorrhagic Fever

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Sources:
5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 56UMLS, 37NDF-RT
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Approved drugs:

Search CenterWatch for crimean-congo hemorrhagic fever

Drug clinical trials:

Search ClinicalTrials for crimean-congo hemorrhagic fever

Search NIH Clinical Center for crimean-congo hemorrhagic fever

Search CenterWatch for crimean-congo hemorrhagic fever

Genetic Tests for Crimean-congo Hemorrhagic Fever

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Anatomical Context for Crimean-congo Hemorrhagic Fever

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Animal Models for Crimean-congo Hemorrhagic Fever or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to crimean-congo hemorrhagic fever:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
digestive/alimentary phenotype
MP:00053818.4VEGFA, MBTPS1, NFKB1, IL6, CASP3, F2
2
respiratory system phenotype
MP:00053888.0STAB2, TNF, VEGFA, NFKB1, IL6, CASP3
3
integument phenotype
MP:00107717.7F3, TNFRSF19, TNF, VEGFA, MBTPS1, NFKB1
4
muscle phenotype
MP:00053697.5STAB2, TNF, VEGFA, PARVA, NFKB1, IL6
5
cardiovascular system phenotype
MP:00053856.9STAB2, TNFRSF19, TNF, VEGFA, PARVA, IL6
6
homeostasis/metabolism phenotype
MP:00053766.1VEGFA, TNF, TNFRSF19, STAB2, SLC17A5, MBTPS1

Publications for Crimean-congo Hemorrhagic Fever

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47PubMed
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Articles related to crimean-congo hemorrhagic fever:

(show all 15)
idTitleAuthorsYearAffiliating Genes
1Relationship between NF-kB1 and NF-kBIA genetic polymo rphisms and Crimean-Congo hemorrhagic fever. (22066734)Arslan S.... Engin A.2012NFKB1
2Structure of Crimean-Congo hemorrhagic fever virus nuc leoprotein: superhelical homo-oligomers and the role of caspase-3 cleavage. (22951837)Wang Y.... Kotaka M.2012CASP3
3Evaluation of the association of serum levels of hyal uronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patie nts with Crimean-Congo hemorrhagic fever. (20005156)Ozturk B.... Tuzun H.2010VEGFA, SLC17A5
4Comparison of antiviral activity of recombinant and n atural interferons against crimean-congo hemorrhagic Fever virus. (20517491)Karlberg H.... Mirazimi A.2010ISG20
5An outbreak of Crimean-Congo hemorrhagic fever in wes tern Anatolia, Turkey. (19409826)Ertugrul B.... Sakarya S.2009GPT
6Two Crimean-Congo hemorrhagic fever cases without hi story of tick contact from Ankara region (20084924)Kaya KiliAs E.... DemirAPz A.P.2009F2
7Serum chitotriosidase enzyme activity in patients wit h Crimean-Congo hemorrhagic fever. (19883210)Kurt Y.G.... Erbil M.K.2009CHIT1
8Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity. (17898072)Bergeron E.... Nichol S.T.2007MBTPS1
9Crimean-Congo hemorrhagic fever. (17367225)Mardani M.... Keshtkar-Jahromi M.2007F2, F3
10Cytokine levels in Crimean-Congo hemorrhagic fever. (16765637)Papa A.... Antoniadis A.2006IL6
11Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever. (16518755)Ergonul O.... Dokuzoguz B.2006IL6, TNF
12Recombinant nucleoprotein-based serological diagnosis of Crimean-Congo hemorrhagic fever virus infections. (15602720)Saijo M.... Morikawa S.2005RNPC3
13Antigen-capture enzyme-linked immunosorbent assay for the diagnosis of crimean-congo hemorrhagic fever using a novel monoclonal antibody. (16032715)Saijo M.... Morikawa S.2005RNPC3
14Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus. (15047845)Andersson I.... Mirazimi A.2004MX1
15Crimean-Congo hemorrhagic fever (11521472)Djokic M.... Drmanic S.2000F2, F3

Variations for Crimean-congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-congo Hemorrhagic Fever

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Crimean-congo Hemorrhagic Fever

Pathways for genes affiliated with Crimean-congo Hemorrhagic Fever

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54Thomson Reuters, 48QIAGEN, 34NCBI BioSystems Database, 27KEGG, 12EMD Millipore, 49R&D Systems
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Pathways related to crimean-congo hemorrhagic fever according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response_Bacterial infections in normal airways54
9.7IL6, NFKB1, TNF
2
IL-10 Pathway48
9.7TNF, NFKB1, IL6
3
amb2 Integrin signaling34
9.7TNF, NFKB1, IL6
4
LPA receptor mediated events34
9.6CASP3, IL6, NFKB1
5
Measles27
Hide members
9.5IL6, MX1, NFKB1, TNF
6
Immune response_IL-1 signaling pathway54
Hide members
9.4F3, IL6, NFKB1, TNF
7
Selenium Pathway34
9.4TNF, NFKB1, IL6, F2
8
Tuberculosis27
9.3TNF, NFKB1, IL6, CASP3
9
Colorectal Cancer Metastasis48
9.3TNF, NFKB1, IL6, CASP3
10
Pertussis27
9.3CASP3, IL6, NFKB1, TNF
11
TWEAK Pathway48
Hide members
9.3CASP3, IL6, NFKB1, TNF
12
Amoebiasis27
9.3CASP3, IL6, NFKB1, TNF
13
Integrated Pancreatic Cancer Pathway34
9.3TNF, VEGFA, NFKB1, CASP3
14
SIDS Susceptibility Pathways34
9.1TNF, VEGFA, NFKB1, IL6, CASP3
15
TRAF Pathway48
Hide members
8.9CASP3, NFKB1, TNF, TNFRSF19
16
PEDF Induced Signaling48
Hide members
8.5CASP3, IL6, NFKB1, VEGFA, TNF, TNFRSF19

Compounds for genes affiliated with Crimean-congo Hemorrhagic Fever

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41Novoseek, 11DrugBank, 55Tocris Bioscience, 46PharmGKB, 22HMDB, 2BitterDB
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Compounds related to crimean-congo hemorrhagic fever according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1pdtc4110.5CASP3
2d-galactosamine4110.4SLC17A5, GPT
3silymarin4110.4GPT, SLC17A5
4aminopyrine4110.4F2, SLC17A5
5brodifacoum4110.4F2, F3
6mnpt4110.4F3, F2
7napsagatran4110.4F3, F2
8aprosulate4110.4F3, F2
9nash4110.3GPT, SLC17A5, CHIT1
10appt4110.3F3, F2
11ximelagatran41 1111.3GPT, F2, F3
12hemochron4110.2F2, F3
13ciglitazone4110.2CASP3
14levonorgestrel41 1111.1F3, F2, SLC17A5
15imiquimod41 55 1112.1IL6, TNF, MX1
16rosuvastatin41 46 1112.1GPT, IL6, SLC17A5
17hepaplastin4110.1F3, F2, GPT, SLC17A5
185-hydroxytryptophol4110.0GPT, SLC17A5
19sb 20358041 5511.0F3, CASP3, VEGFA
20aprotinin41 1111.0F3, F2, IL6, SLC17A5
21tpck4110.0TNF, IL6, CASP3
22pge1419.9SLC17A5, GPT, F2, IL6
23hyaluronic acid41 2210.9STAB2, IL6, F2
24fenofibrate41 1110.9GPT, TNF, SLC17A5, IL6
25bay 11-7821559.9NFKB1, TNF
26zoledronic acid419.9CASP3, IL6, VEGFA
27protamine419.9IL6, F2, F3, RNPC3
28gm-csf419.8IL6, VEGFA, TNF
29ribavirin41 46 1111.8ISG20, GPT, MX1, SLC17A5
30triptolide419.8VEGFA, TNF, IL6, CASP3
31bay 11-7085559.8TNF, NFKB1
32thalidomide41 46 55 1112.8TNF, IL6, NFKB1, VEGFA
3315-deoxy-delta-12,14-prostaglandin j2419.8TNF, CASP3, IL6, VEGFA
34inogatran419.8F2, F3
35rosiglitazone41 46 11 2212.8SLC17A5, TNF, IL6, GPT
36parthenolide41 210.7CASP3, TNF, IL6
37prednisolone41 1110.7GPT, SLC17A5, TNF, IL6
38sp 60012541 5510.7IL6, TNF, CASP3, F3
39atorvastatin41 46 11 2212.7GPT, VEGFA, IL6, TNF, SLC17A5
40methotrexate41 46 55 1112.7SLC17A5, TNF, GPT, IL6, F2
41aebsf419.6F3, CASP3, MBTPS1, TNF
42troglitazone41 55 1111.6GPT, SLC17A5, IL6, TNF, CASP3
432,5-oligoadenylate419.6GPT, MX1, TNF, IL6, ISG20
44neopterin419.6SLC17A5, TNF, GPT, IL6, CHIT1, MX1
45fibrinogen419.3GPT, TNF, F2, CHIT1, SLC17A5, IL6
46lactate419.3SLC17A5, TNF, IL6, GPT, CASP3, F2
47cycloheximide419.2TNF, VEGFA, MX1, IL6, F3, CASP3
48n acetylcysteine419.2GPT, VEGFA, IL6, CASP3, F2, TNF
49cyclosporin a41 5510.0SLC17A5, F2, TNF, RNPC3, GPT, IL6
50simvastatin41 46 55 11 2213.0F2, F3, CASP3, IL6, GPT, VEGFA

GO Terms for genes affiliated with Crimean-congo Hemorrhagic Fever

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15Gene Ontology
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Cellular components related to crimean-congo hemorrhagic fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1F3, F2, CHIT1, IL6, VEGFA, TNF

Biological processes related to crimean-congo hemorrhagic fever according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of positive chemotaxisGO:05092710.0F3, VEGFA
2negative regulation of lipid storageGO:01088810.0TNF, IL6
3epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.0IL6, TNF
4positive regulation of peptidyl-serine phosphorylationGO:0331389.8IL6, VEGFA, TNF
5positive regulation of protein kinase B signaling cascadeGO:0518979.5F3, IL6, TNF
6regulation of cell shapeGO:0083609.1F2, IL6, PARVA, VEGFA
7negative regulation of apoptotic processGO:0430669.0TNF, VEGFA, NFKB1, IL6, CASP3, F3
8induction of apoptosisGO:0069179.0TNFRSF19, TNF, MX1, CASP3

Products for genes affiliated with Crimean-congo Hemorrhagic Fever

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  • Antibodies
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Sources for Crimean-congo Hemorrhagic Fever

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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