Crimean-Congo Hemorrhagic Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

Sources:
²CDC, ¹¹Disease Ontology, ¹³DISEASES, ³⁰ICD10, ³¹ICD10 via Orphanet, ³²ICD9CM, ³⁹MeSH, ⁴⁵NCIt, ⁵⁰Novoseek, ⁵⁴Orphanet, ⁶²SNOMED-CT, ⁶⁸UMLS
See all MalaCards sources

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever ¹¹ ⁵⁴ ² ¹³

Hemorrhagic Fever, Crimean ³⁹ ⁶⁸

Crimean Hemorrhagic Fever ¹¹ ⁵⁴

Congo Hemorrhagic Fever ⁵⁴ ⁶⁸

Cchf ⁵⁴ ²

Congo-Crimean Hemorrhagic Fever ¹¹

Hemorrhagic Fever Crimean-Congo ⁵⁰

Chf Congo Virus ¹¹

Congo Fever ⁵⁴

Characteristics:

Orphanet epidemiological data:

⁵⁴

crimean-congo hemorrhagic fever:
Age of onset: All ages; Age of death: any age

Classifications:

MalaCards categories:
Global: Infectious diseases, Rare diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³⁰

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Other viral haemorrhagic fevers, not elsewhere classified

Crimean-Congo haemorrhagic fever

Orphanet: ⁵⁴

Rare infectious diseases

External Ids:

Disease Ontology¹¹ DOID:12287

ICD10³⁰ A98.0

ICD9CM³² 065.0

MeSH³⁹ D006479

SNOMED-CT⁶² 43489008

NCIt⁴⁵ C34682

Orphanet⁵⁴ ORPHA99827

ICD10 via Orphanet³¹ A98.0

UMLS⁶⁸ C0019099

Summaries for Crimean-Congo Hemorrhagic Fever

Sources:
²CDC, ¹¹Disease Ontology, ³⁶MalaCards
See all MalaCards sources

Disease Ontology:¹¹ A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to hemorrhagic fever and rift valley fever, and has symptoms including Array, Array and Array. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways are Overview of nanoparticle effects and Cytokines and Inflammatory Response. Affiliated tissues include eye, skin and testes, and related mouse phenotypes are digestive/alimentary and integument.

CDC:² Crimean-Congo hemorrhagic fever is found in Eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

Related Diseases for Crimean-Congo Hemorrhagic Fever

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)

id	Related Disease	Score	Top Affiliating Genes
1	hemorrhagic fever	11.4
2	rift valley fever	10.4
3	endotheliitis	10.3
4	vps11-related autosomal recessive hypomyelinating leukodystrophy	10.2	IL6, TNF
5	dyslexia 5	10.2	IL6, TNF
6	aortic atherosclerosis	10.2	IL6, TNF
7	unilateral multicystic dysplastic kidney	10.2	IL6, TNF
8	thymic neuroendocrine carcinoma	10.2	IL6, TNF
9	swine influenza	10.2	IL6, TNF
10	drug dependence	10.2	IL6, TNF
11	senile atrophy of choroid	10.2	CASP3, VEGFA
12	transient tic disorder	10.2	IL6, TNF
13	west nile virus	10.2
14	tick-borne encephalitis	10.2
15	encephalitis	10.2
16	anal paget's disease	10.2	IL6, TNF
17	papilledema	10.2	IL6, TNF
18	angiomatosis, diffuse corticomeningeal, of divry and van bogaert	10.2	IL6, TNF
19	aortic coarctation	10.1	IL6, TNF
20	preaxial polydactyly of fingers	10.1	IL6, TNF
21	human immunodeficiency virus infectious disease	10.1	IL6, TNF
22	craniosynostosis, type 1	10.1	IL6, VEGFA
23	secretory diarrhea myopathy and deafness	10.1	F3, IL6
24	cardiac tuberculosis	10.1	IL6, VEGFA
25	esophagus lymphoma	10.1	IL6, TNF
26	immunoglobulin g deficiency	10.1	CASP3, IL6, TNF
27	splenic marginal zone lymphoma	10.1	CASP3, IL6, TNF
28	depressed scar	10.1	F3, IL6, TNF
29	meningitis	10.1	CASP3, IL6, TNF
30	membranoproliferative glomerulonephritis	10.1	F3, IL6, TNF
31	tinea capitis	10.1	IL6, TNF
32	uterine corpus cancer	10.1	CXCL10, F3, TNF
33	prinzmetal's variant angina	10.0	CASP3, IL6, VEGFA
34	tracheal calcification	10.0	GPT, TNF
35	placenta praevia	10.0	CASP3, TNF, VEGFA
36	degenerative disc disease	10.0	IL6, TNF, VEGFA
37	vulvitis	10.0	F3, IL6, VEGFA
38	conjugate gaze palsy	10.0	IL6, VEGFA
39	bipolar i disorder	10.0	IL6, TNF, VEGFA
40	leukoplakia of vagina	10.0	IL6, TNF, VEGFA
41	ectodermal dysplasia bartalos type	10.0	IL6, TNF, VEGFA
42	bladder signet ring cell adenocarcinoma	10.0	CXCL10, IL6, TNF
43	choanal atresia, bilateral	10.0	CXCL10, IL6, TNF
44	malaria	10.0
45	pulmonary hypertension	10.0
46	hemophagocytic lymphohistiocytosis	10.0
47	thrombocytopenia	10.0
48	parotitis	10.0
49	thrombotic thrombocytopenic purpura	10.0
50	hemorrhagic fever with renal syndrome	10.0

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

Sources:
¹¹Disease Ontology, ⁴¹MGI, ⁵⁴Orphanet, ⁶⁴The Human Phenotype Ontology
See all MalaCards sources

Symptoms:

¹¹ (show all 13)

• headache
• high fever
• back pain
• joint pain
• stomach pain
• vomiting
• red eyes

• flushed face
• red throat
• petechiae (red spots) on the palate
• jaundice
• nosebleeds
• blood in the feces

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

⁵⁴ ⁶⁴ (show all 23)

id	Description	Orphanet Frequency	HPO Source Accession
1	gingival bleeding⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0000225
2	epistaxis⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0000421
3	uveitis⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0000554
4	jaundice⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0000952
5	petechiae⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0000967
6	skin rash⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0000988
7	hepatic steatosis⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0001397
8	thrombocytopenia⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0001873
9	leukopenia⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0001882
10	abnormal bleeding⁵⁴	Occasional (29-5%)
11	fever⁶⁴ ⁵⁴	Very frequent (99-80%)	HP:0001945
12	diarrhea⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002014
13	nausea and vomiting⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002017
14	abdominal pain⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002027
15	gastrointestinal hemorrhage⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0002239
16	headache⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002315
17	elevated hepatic transaminases⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002910
18	myalgia⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0003326
19	cardiorespiratory arrest⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0006543
20	fatigue⁶⁴ ⁵⁴	Very frequent (99-80%)	HP:0012378
21	cough⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0012735
22	chest pain⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0100749
23	recurrent pharyngitis⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0100776

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	8.9	CASP3, IL6, NFKB1, TNF, VEGFA
2	integument	MP:0010771	8.5	CASP3, F3, IL6, NFKB1, TNF, VEGFA
3	muscle	MP:0005369	8.5	CASP3, F3, IL6, NFKB1, TNF, VEGFA
4	cellular	MP:0005384	8.1	CASP3, CXCL10, F3, IL6, NFKB1, TNF
5	nervous system	MP:0003631	8.0	CASP3, CXCL10, F3, IL6, NFKB1, TNF
6	respiratory system	MP:0005388	7.7	CASP3, F3, IL6, NFKB1, TNF, VEGFA
7	homeostasis/metabolism	MP:0005376	7.7	CASP3, CXCL10, F3, IL6, NFKB1, TLR8
8	immune system	MP:0005387	7.7	CASP3, CXCL10, F3, IL6, NFKB1, TLR8
9	hematopoietic system	MP:0005397	6.9	CASP3, CXCL10, F3, GPT, IL6, NFKB1

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Sources:
¹BitterDB, ⁴ClinicalTrials, ⁷Cochrane Library, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁴⁶NDF-RT, ⁵⁰Novoseek, ⁵⁶PharmGKB, ⁶⁸UMLS
See all MalaCards sources

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Ribavirin

approved

Phase 2

1003

36791-04-5

37542

Synonyms:

1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide

36791-04-5

437710-49-1

66510-90-5

AA-504/07617051

AB00430481

AC1L1XXZ

AC1Q1IDC

AC1Q4ZGS

AKOS001715163

BB_NC-0567

BPBio1_001195

BRN 0892462

BSPBio_001085

BSPBio_003352

C-Virin

CHEMBL1643

CID37542

Copegus

Copegus (TN)

Cotronak

D00423

DB00811

DRG-0028

DivK1c_000782

Drug: Ribavirin

EU-0101063

FT-0082885

HMS2090L15

HMS2094O09

HMS502H04

HSDB 6513

ICN-1229

IDI1_000782

KBio1_000782

KBio2_002328

KBio2_004896

KBio2_007464

KBio3_002854

KBioGR_001804

KBioSS_002331

KS-1104

LS-1241

Lopac0_001063

MLS000028486

MLS002222317

MolPort-002-507-104

MolPort-002-885-856

NCGC00090726-01

NCGC00090726-03

NCGC00090726-04

NCGC00090726-05

NCGC00090726-06

NCGC00090726-07

NINDS_000782

NSC 163039

NSC163039

Prestwick3_000993

R 9644

R-964

R9644_SIGMA

RBV

RG-964

RIBAV

RTC

RTCA

RTP

Ravanex

Rebetol

Rebetol (TN)

Rebetron

Rebretron

Ribacine

Ribamide

Ribamidil

Ribamidyl

Ribasphere

Ribasphere (TN)

Ribav

Ribavirin

Ribavirin (JAN/USP/INN)

Ribavirin Capsules

Ribavirin Triphosphate

Ribavirin [USAN:INN]

Ribavirin-TP

Ribavirina

Ribavirina [INN-Spanish]

Ribavirine

Ribavirine [INN-French]

Ribavirinum

Ribavirinum [INN-Latin]

Ribovirin

Ro 20-9963/000

Ro-20-9963

S2504_Selleck

SCH 18908

SMP1_000261

SMR000058315

SPECTRUM1503938

SR-01000076112-3

Spectrum3_001876

Spectrum4_001252

Spectrum5_002075

Spectrum_001826

Tribavirin

UNII-49717AWG6K

Varazid

Vilona

Viramid

Viramide

Virazid

Virazide

Virazole

Virazole (Ribavirin) Inhalation Solution

Virazole (TN)

Virazole 5'-triphosphate

ZINC01035331

ribavirin

2

Antimetabolites

Phase 2

12054

3

Anti-Infective Agents

Phase 2

22062

4

Antiviral Agents

Phase 2

9967

5

Formaldehyde

approved, vet_approved

Phase 1

93

50-00-0

712

Synonyms:

Aldeide formica

Fannoform

Formaldehyde

Formalin

Formalina

Formaline

Formalith

Formic aldehyde

Formol

Methaldehyde

Methanal

Methyl aldehyde

Methylene glycol

Methylene oxide

Oxomethane

Oxomethylene

Oxymethylene

Paraform

Paraformaldehyde

6

Vaccines

Phase 1

6611

7

Pharmaceutical Solutions

Phase 1

8192

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities	Enrolling by invitation	NCT00992693	Phase 2
2	Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans	Active, not recruiting	NCT03020771	Phase 1
3	Cohort of Patients Infected by an Arbovirus	Recruiting	NCT01099852
4	Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever	Enrolling by invitation	NCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

³⁶

Eye, Skin, Testes, Endothelial, Heart, Neutrophil

Publications for Crimean-Congo Hemorrhagic Fever

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 499)

id	Title	Authors	Year
1	Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran. (27308275)	Champour M.... Jalali T.	2016
2	Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. (27353580)	Gazi H.... Horasan G.D.	2016
3	Does Crimean-Congo Hemorrhagic Fever Cause a Vasculitic Reaction with Pulmonary Artery Enlargement and Acute Pulmonary Hypertension? (27344326)	AktaA9 T.... Kaya T.	2016
4	The prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever. (27089100)	Yilmaz H.... KAPksal A.^.	2016
5	Multi-center prospective evaluation of discharge criteria for hospitalized patients with Crimean-Congo Hemorrhagic Fever. (27424492)	Leblebicioglu H.... Ozaras R.	2016
6	Crimean-Congo Hemorrhagic Fever Knowledge, Attitudes, Practices, Risk Factors, and Seroprevalence in Rural Georgian Villages with Known Transmission in 2014. (27336731)	Greiner A.L.... Salyer S.J.	2016
7	Crimean-Congo hemorrhagic fever among children in Iran. (27878461)	Aslani D.... Fazlalipour M.	2016
8	A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus. (27713073)	Spengler J.R.... Bente D.A.	2016
9	Relationship between IFNA1, IFNA5, IFNA10, and IFNA17 gene polymorphisms and Crimean-Congo hemorrhagic fever prognosis in a Turkish population range. (26694082)	Elaldi N.... Dokmetas I.	2016
10	Determination of nasal mucociliary clearance time and nasal symptom in patients with crimean-congo hemorrhagic fever. (27813123)	DurmuA9 K.... Altuntas E.E.	2016
11	Crimean-Congo Hemorrhagic Fever in Dubai, United Arab Emirates, 2010: Case Report. (27795839)	Mohamed Al Dabal L.... Alwan A.M.	2016
12	Phylogeography of Crimean Congo Hemorrhagic Fever Virus. (27880794)	Lukashev A.N.... Gmyl A.P.	2016
13	Biosafety standards for working with Crimean-Congo hemorrhagic fever virus. (27667586)	Weidmann M.... Zeller H.	2016
14	PRESEPSIN LEVELS OF PATIENTS WITH CRIMEAN-CONGO HEMORRHAGIC FEVER. (27000451)	DemirpenAse A.9.... BakA+r M.	2016
15	Examination of the specific clinical symptoms and laboratory findings of Crimean-Congo hemorrhagic fever. (27353587)	Kilinc C.... Menekse E.	2016
16	Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses. (27217069)	MA1ller M.A.... Drosten C.	2016
17	Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. (27110812)	Zivcec M.... Bergeron A.8.	2016
18	A competitive ELISA for species-independent detection of Crimean-Congo hemorrhagic fever virus specific antibodies. (27623345)	Schuster I.... Groschup M.H.	2016
19	Crimean-Congo Hemorrhagic Fever with Acute Subdural Hematoma, Mauritania, 2012. (27315138)	Kleib A.S.... Bettar E.S.	2016
20	The prognostic significance of serum TGF-I^1 levels in patients with Crimean-Congo hemorrhagic fever. (27467498)	Yilmaz G.... KAPksal A.^.	2016
21	A retrospective controlled study of thiol disulfide homeostasis as a novel marker in Crimean Congo hemorrhagic fever. (27159644)	Tufan Z.K.... Guner R.	2016
22	Molecular analysis of Crimean-Congo hemorrhagic fever virus and Rickettsia in Hyalomma marginatum ticks removed from patients (Spain) and birds (Spain and Morocco), 2009-2015. (27215620)	Palomar A.M.... Oteo J.A.	2016
23	Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana. (27392037)	Akuffo R.... Dueger E.	2016
24	Protective role of host aquaporin 6 against Hazara virus, a model for Crimean-Congo hemorrhagic fever virus infection. (26976854)	Molinas A.... VikstrAPm E.	2016
25	Phylogeny of tick-derived Crimean-Congo hemorrhagic fever virus strains in Iran. (27491289)	Biglari P.... Shahhosseini N.	2016
26	Possible sexual transmission of Crimean-Congo hemorrhagic fever. (26972040)	Pshenichnaya N.Y.... Zhuravlev A.S.	2016
27	Molecular Assay on Crimean Congo Hemorrhagic Fever Virus in Ticks (Ixodidae) Collected from Kermanshah Province, Western Iran. (27308296)	Mohammadian M.... Farhadpour F.	2016
28	Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity. (27775001)	Xia H.... Bente D.A.	2016
29	Seroprevalence of Crimean-Congo hemorrhagic fever in Turkey's Van Province. (27169950)	Bayram Y.... Andac C.A.	2016
30	MicroRNA expression profiles in patients with acute Crimean Congo Hemorrhagic Fever reveal possible adjustments to cellular pathways. (27551771)	Demir Z.C.... Ozkul A.	2016
31	A child with an unusual complication of Crimean-Congo hemorrhagic fever: Hemorrhagic pleural effusion. (27004585)	Sahin I.O.... Arslan M.	2016
32	Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. (27666016)	Wang X.... Lou Z.	2016
33	Thorax CT findings in patients with Crimean-Congo hemorrhagic fever (CCHF). (27818861)	AktaA9 T.... Demir O.	2016
34	Crimean-Congo hemorrhagic fever virus lineages Europe 1 and Europe 2 in Bulgarian ticks. (27378409)	Panayotova E.... Christova I.	2016
35	Novel, In-House, SYBR Green Based One-Step rRT-PCR: Rapid and Accurate Diagnosis of Crimean-Congo Hemorrhagic Fever Virus in Suspected Patients From Iran. (27099688)	Zahraei B.... Dorostkar R.	2016
36	Clinical severity in forecasting platelet to lymphocyte ratio in Crimean-Congo hemorrhagic fever patients. (27501696)	Eren S.H.... GAPzel M.G.	2016
37	Epidemiological Survey of Crimean-Congo Hemorrhagic Fever (CCHF), a Fatal Infectious Disease in Khuzestan Province, Southwest Iran, During 1999 - 2015. (27540454)	Sharififard M.... Kamali A.	2016
38	Heat Shock Protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle. (27512070)	Surtees R.... Barr J.N.	2016
39	Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever. (27378224)	Akinci E.... Leblebicioglu H.	2016
40	Serum sTREM-1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection. (26877157)	Altay F.A.... A9encan A.^.	2016
41	Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system. (26935918)	Suda Y.... Shimojima M.	2016
42	The first fatal case of Crimean-Congo Hemorrhagic Fever due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus. (26902209)	Salehi-Vaziri M.... Fazlalipour M.	2016
43	Molecular epidemiology of Crimean-Congo hemorrhagic fever virus detected from ticks of one humped camels (Camelus dromedarius) population in northeastern Iran. (27065608)	Champour M.... Jalali T.	2016
44	Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area. (27677379)	Tanyel E.... Leblebicioglu H.	2016
45	Crimean-Congo Hemorrhagic Fever Virus in Bulgaria and Turkey. (27467142)	Mertens M.... Groschup M.H.	2016
46	Crimean-Congo hemorrhagic fever - A ticking bomb? (27044612)	Al-Abri S.S.... Petersen E.	2016
47	Crimean-Congo hemorrhagic fever with hyperbilirubinemia and ascites: An unusual presentation. (26129885)	Ture Z.... YaA9cA+-A8aA9layA+k D.	2016
48	Sero-epidemiological survey of Crimean-Congo hemorrhagic fever virus in Tunisia. (26956221)	Wasfi F.... Letaief A.	2016
49	Crimean Congo Hemorrhagic Fever Virus and Alkhurma (Alkhumra) Virus in Ticks in Djibouti. (27508862)	Horton K.C.... Dueger E.L.	2016
50	Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran. (27047968)	Chinikar S.... Niedrig M.	2016

Genes related to Crimean-Congo Hemorrhagic Fever

Sources:
¹³DISEASES, ²¹GeneCards
See all MalaCards sources

Genes related to Crimean-Congo Hemorrhagic Fever:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	F3	Coagulation Factor III, Tissue Factor	34.90	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
2	TNF	Tumor Necrosis Factor	32.98	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
3	TLR8	Toll Like Receptor 8	32.83	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
4	IL6	Interleukin 6	32.55	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
5	CXCL10	C-X-C Motif Chemokine Ligand 10	32.38	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
6	NFKB1	Nuclear Factor Kappa B Subunit 1	32.34	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
7	CASP3	Caspase 3	29.36	GeneCards inferred via : Disorders, Publications (show sections)
8	GPT	Glutamic--Pyruvic Transaminase	29.11	GeneCards inferred via : Disorders, Publications (show sections)
9	VEGFA	Vascular Endothelial Growth Factor A	29.11	GeneCards inferred via : Disorders, Publications (show sections)

Variations for Crimean-Congo Hemorrhagic Fever

Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁸QIAGEN, ⁵⁹R&D Systems, ⁶⁰Reactome, ⁶⁵Thomson Reuters
See all MalaCards sources

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 60)

id	Super pathways	Score	Top Affiliating Genes
1	Overview of nanoparticle effects⁴²	9.7	IL6, TNF
2	Cytokines and Inflammatory Response⁴²	9.7	IL6, TNF
3	Transcription factor regulation in adipogenesis⁴²	9.7	IL6, TNF
4	Development and heterogeneity of the ILC family⁴²	9.7	IL6, TNF
5	African trypanosomiasis³⁴	9.7	IL6, TNF
6	EBV LMP1 signaling⁴²	9.6	NFKB1, TNF
7	Canonical NF-kappaB pathway⁴²	9.6	NFKB1, TNF
8	Immune response_IL-6 signaling pathway⁶⁵	9.5	IL6, NFKB1
9	14-3-3 and Regulation of BAD Activity⁵⁸	9.5	CASP3, TNF
10	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis⁴²	9.4	NFKB1, VEGFA
11	IL27-mediated signaling events⁴² Show member pathways IL-12 Family Signaling Pathways⁵⁹ Th1 Differentiation Pathway⁵⁹	9.3	IL6, TLR8, TNF
12	G-protein signaling_RhoB regulation pathway⁶⁵	9.3	CXCL10, IL6, TNF
13	Interleukin-10 signaling⁶⁰	9.3	CXCL10, IL6, TNF
14	Insulin resistance³⁴ Show member pathways protein O-[N-acetyl]-glucosylation⁴²	9.2	IL6, NFKB1, TNF
15	amb2 Integrin signaling⁴²	9.2	IL6, NFKB1, TNF
16	Toll Comparative Pathway⁵⁸ Show member pathways Immune response MIF in innate immunity response⁶⁵ IL-1 Pathway⁵⁸ iNOS Signaling⁵⁸ TLR-TRIF Pathway⁵⁸	9.2	IL6, NFKB1, TNF
17	Folate Metabolism⁴² Show member pathways Vitamin B12 Metabolism⁴² Selenium Micronutrient Network⁴² thioredoxin pathway⁴²	9.2	IL6, NFKB1, TNF
18	IgA-Producing B Cells in the Intestine⁵⁹	9.2	IL6, NFKB1, TNF
19	Antifolate resistance³⁴	9.2	IL6, NFKB1, TNF
20	IL-10 Pathway⁵⁸	9.2	IL6, NFKB1, TNF
21	Rheumatoid arthritis³⁴	9.2	IL6, TNF, VEGFA
22	Interleukin-4 and 13 signaling⁶⁰	9.2	IL6, TNF, VEGFA
23	Fluid shear stress and atherosclerosis³⁴	9.1	NFKB1, TNF, VEGFA
24	Aryl Hydrocarbon Receptor⁴²	9.1	NFKB1, TNF, VEGFA
25	HIF-1 signaling pathway³⁴	9.0	IL6, NFKB1, VEGFA
26	Toxoplasmosis³⁴ Show member pathways Leishmaniasis³⁴	9.0	CASP3, NFKB1, TNF
27	Immune response Function of MEF2 in T lymphocytes⁶⁵ Show member pathways Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis⁶⁵	9.0	CASP3, NFKB1, TNF
28	Ceramide Pathway⁵⁸ Show member pathways TNF-Induced Apoptosis Implicating Sphingolipids⁵⁸	9.0	CASP3, NFKB1, TNF
29	Proteoglycans in cancer³⁴	9.0	CASP3, TNF, VEGFA
30	LPA receptor mediated events⁴²	8.9	CASP3, IL6, NFKB1
31	NF-KappaB Family Pathway⁵⁸ Show member pathways NF-KappaB (p50-p65) Pathway⁵⁸	8.8	IL6, NFKB1, TLR8, TNF
32	Diseases associated with the TLR signaling cascade⁶⁰ Show member pathways Diseases of Immune System⁶⁰ MyD88 deficiency (TLR2/4)⁶⁰ TLR4 Signaling and Tolerance⁴² Toll-like Receptor Signaling⁴² IRAK4 deficiency (TLR2/4)⁶⁰ Simplified Depiction of MYD88 Distinct Input-Output Pathway⁴² MyD88 deficiency (TLR5)⁶⁰ IRAK4 deficiency (TLR5)⁶⁰ Interleukin-1 Induced Activation of NF-kappa-B⁴² IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation⁶⁰ IRAK1 recruits IKK complex⁶⁰	8.8	IL6, NFKB1, TLR8, TNF
33	G-protein signaling Ras family GTPases in kinase cascades (scheme)⁶⁵ Show member pathways Oncostatin M Signaling Pathway⁴² Immune response Oncostatin M signaling via MAPK in human cells⁶⁵ MAPK Cascade⁴² Activation of the AP-1 family of transcription factors⁶⁰	8.8	CASP3, NFKB1, VEGFA
34	Integrated Breast Cancer Pathway⁴²	8.8	CASP3, NFKB1, VEGFA
35	NF-kappaB Signaling³	8.8	CXCL10, NFKB1, TLR8, TNF
36	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways⁶⁰ Show member pathways TRAF3-dependent IRF activation pathway⁶⁰ TRAF6 mediated IRF7 activation⁶⁰ Cytosolic DNA-sensing pathway³⁴ RIG-I-like Receptor Signaling⁴² Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR)⁵⁹ RIG-I-like receptor signaling pathway³⁴ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10⁶⁰ Negative regulators of RIG-I/MDA5 signaling⁶⁰	8.7	CXCL10, IL6, NFKB1, TNF
37	Photodynamic therapy-induced NF-kB survival signaling⁴² Show member pathways Immune response MIF-mediated glucocorticoid regulation⁶⁵	8.7	IL6, NFKB1, TNF, VEGFA
38	Spinal Cord Injury⁴²	8.6	CASP3, CXCL10, IL6, TNF
39	Pertussis³⁴	8.6	CASP3, IL6, NFKB1, TNF
40	Legionellosis³⁴	8.6	CASP3, IL6, NFKB1, TNF
41	TNFR1 Pathway⁵⁸ Show member pathways Apoptosis and survival TNFR1 signaling pathway⁶⁵ Apoptosis through Death Receptors⁵⁸ Fas Signaling⁵⁸ TNF Signaling⁵⁸ TNF alpha Signaling Pathway⁴² TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway⁴² TRAIL Pathway⁵⁸ DR3 Signaling⁵⁸ TWEAK Pathway⁵⁸ HIV-1 Nef- Negative effector of Fas and TNF-alpha⁴² Apoptotic Pathways Triggered By HIV1⁵⁸ GITR Pathway⁵⁸ Stimulation of the cell death response by PAK-2p34⁶⁰	8.6	CASP3, IL6, NFKB1, TNF
42	Amoebiasis³⁴	8.6	CASP3, IL6, NFKB1, TNF
43	Tuberculosis³⁴	8.6	CASP3, IL6, NFKB1, TNF
44	Allograft rejection⁴² ³⁴ Show member pathways Allograft Rejection⁴² Viral myocarditis³⁴ Asthma³⁴ CTL Mediated Apoptosis⁵⁸ Intestinal immune network for IgA production³⁴ Autoimmune thyroid disease³⁴ Type I diabetes mellitus³⁴ Graft-versus-host disease³⁴ Antigen processing and presentation³⁴ THC Differentiation Pathway⁵⁸	8.6	CASP3, IL6, TNF, VEGFA
45	Toll-Like receptor Signaling Pathways⁵⁹ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways⁵⁹ Immune response IL-1 signaling pathway⁶⁵ NOD-like receptor signaling pathway³⁴ Mucin expression in CF via TLRs, EGFR signaling pathways⁶⁵ Inflammasome Activation Pathways⁵⁹ IL-1 Family Signaling Pathways⁵⁹ NOD-like Receptor Signaling Pathways⁵⁹ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway⁶⁵	8.5	F3, IL6, NFKB1, TLR8, TNF
46	Pathways in cancer³⁴	8.4	CASP3, IL6, NFKB1, VEGFA
47	Hepatitis C and Hepatocellular Carcinoma⁴²	8.4	CASP3, IL6, NFKB1, VEGFA
48	Bacterial infections in CF airways⁶⁵ Show member pathways Immune response Bacterial infections in normal airways⁶⁵ Immune response TLR signaling pathways⁶⁵ IL-1 beta-dependent CFTR expression⁶⁵	8.4	CXCL10, IL6, NFKB1, TLR8, TNF
49	TNF signaling pathway³⁴	8.1	CASP3, CXCL10, IL6, NFKB1, TNF
50	Influenza A³⁴ Show member pathways Herpes simplex infection³⁴ Measles³⁴	8.1	CASP3, CXCL10, IL6, NFKB1, TNF

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.7	CXCL10, IL6, TLR8, TNF
2	extracellular region	GO:0005576	8.6	CXCL10, F3, IL6, NFKB1, TNF, VEGFA
3	extracellular space	GO:0005615	7.6	CXCL10, F3, GPT, IL6, TNF, VEGFA

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of interleukin-8 biosynthetic process	GO:0045416	10.5	TLR8, TNF
2	epithelial cell proliferation involved in salivary gland morphogenesis	GO:0060664	10.5	IL6, TNF
3	negative regulation of lipid storage	GO:0010888	10.5	IL6, TNF
4	positive regulation of chemokine production	GO:0032722	10.5	IL6, TNF
5	negative regulation of myoblast differentiation	GO:0045662	10.4	CXCL10, TNF
6	cellular response to nicotine	GO:0071316	10.4	NFKB1, TNF
7	positive regulation of positive chemotaxis	GO:0050927	10.4	F3, VEGFA
8	positive regulation of protein complex assembly	GO:0031334	10.3	TNF, VEGFA
9	response to auditory stimulus	GO:0010996	10.2	CXCL10, IL6
10	positive regulation of protein kinase B signaling	GO:0051897	10.1	F3, IL6, TNF
11	response to antibiotic	GO:0046677	10.1	CASP3, IL6
12	defense response to virus	GO:0051607	10.0	CXCL10, IL6, TLR8
13	I-kappaB kinase/NF-kappaB signaling	GO:0007249	10.0	NFKB1, TLR8, TNF
14	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	10.0	CASP3, F3, TNF
15	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.9	IL6, NFKB1, TNF
16	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.9	IL6, TNF, VEGFA
17	positive regulation of cell migration	GO:0030335	9.9	CXCL10, F3, VEGFA
18	regulation of cell proliferation	GO:0042127	9.9	CXCL10, IL6, TNF
19	response to glucocorticoid	GO:0051384	9.7	CASP3, IL6, TNF
20	response to lipopolysaccharide	GO:0032496	9.5	CASP3, CXCL10, IL6
21	cellular response to lipopolysaccharide	GO:0071222	9.5	CXCL10, IL6, NFKB1, TNF
22	response to virus	GO:0009615	9.3	CXCL10, TLR8, TNF
23	negative regulation of apoptotic process	GO:0043066	9.1	CASP3, IL6, NFKB1, VEGFA
24	inflammatory response	GO:0006954	9.1	CXCL10, IL6, NFKB1, TLR8, TNF
25	positive regulation of transcription from RNA polymerase II promoter	GO:0045944	8.9	CXCL10, IL6, NFKB1, TNF, VEGFA