Crimean-Congo Hemorrhagic Fever (CCHF) malady

Disease Ontology:⁹ A viral infectious disease that is a hemorrhagic fever, has material basis in crimean-congo hemorrhagic fever virus, which is transmitted by hyalomma ticks. the infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as crimean hemorrhagic fever, is related to thrombocytopenia and malaria, and has symptoms including abnormality of temperature regulation, skin rash and hepatic steatosis. An important gene associated with Crimean-Congo Hemorrhagic Fever is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are TRAF Pathway and Toll Like Receptor 7/8 (TLR7/8) Cascade. The compounds fibrinogen and neopterin have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related mouse phenotype immune system.

CDC:⁴ Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was first characterized in the Crimea in 1944 and given the name Crimean hemorrhagic fever. It was then later recognized in 1969 as the cause of illness in the Congo, thus resulting in the current name of the disease.

External Ids:

Disease Ontology9 DOID:12287 NCIt39 C34682 MeSH34 D006479 SNOMED-CT56 43489008

ICD9CM28 065.0 ICD10 via Orphanet27 A98.0 ICD1026 A98.0 UMLS61 C0019099

Symptoms:

 ^48 9 (show all 37)

fever/chilling asthenia/fatigue/weakness chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis cutaneous rash purpura/petichiae pharyngitis nausea/vomiting/regurgitation/merycism/hyperemesis acute abdominal pain/colic acute diarrhea liver/hepatic steatosis abnormal hepatic enzymes/transaminases cough facial pain/cephalalgia/migraine myalgia/muscular pain gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia hepatitis/icterus/cholestasis thoracic/chest pain collapse/sudden death/cardiac arrest/cardiorespiratory arrest leukopenia/hypoleukocytosis

thrombocytopenia/thrombopenia hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding epistaxis/nose bleeding gingivorrhagia/gingival bleeding early death/lethality headache high fever back pain joint pain stomach pain vomiting red eyes flushed face red throat petechiae (red spots) on the palate jaundice nosebleeds blood in the feces

HPO human phenotypes related to Crimean-Congo Hemorrhagic Fever:

(show all 20)

id	Description	Frequency	HPO Source Accession
1	abnormality of temperature regulation	hallmark (90%)	HP:0004370
2	skin rash	typical (50%)	HP:0000988
3	hepatic steatosis	typical (50%)	HP:0001397
4	subcutaneous hemorrhage	typical (50%)	HP:0001933
5	diarrhea	typical (50%)	HP:0002014
6	nausea and vomiting	typical (50%)	HP:0002017
7	abdominal pain	typical (50%)	HP:0002027
8	migraine	typical (50%)	HP:0002076
9	elevated hepatic transaminases	typical (50%)	HP:0002910
10	myalgia	typical (50%)	HP:0003326
11	inflammatory abnormality of the eye	typical (50%)	HP:0100533
12	recurrent pharyngitis	typical (50%)	HP:0100776
13	gingival bleeding	occasional (7.5%)	HP:0000225
14	epistaxis	occasional (7.5%)	HP:0000421
15	sudden cardiac death	occasional (7.5%)	HP:0001645
16	thrombocytopenia	occasional (7.5%)	HP:0001873
17	leukopenia	occasional (7.5%)	HP:0001882
18	abnormality of coagulation	occasional (7.5%)	HP:0001928
19	gastrointestinal hemorrhage	occasional (7.5%)	HP:0002239
20	chest pain	occasional (7.5%)	HP:0100749

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.