Crimean-Congo Hemorrhagic Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

Sources:
²CDC, ¹¹Disease Ontology, ¹³DISEASES, ³⁰ICD10, ³¹ICD10 via Orphanet, ³²ICD9CM, ³⁹MeSH, ⁴⁵NCIt, ⁵⁰Novoseek, ⁵⁴Orphanet, ⁶²SNOMED-CT, ⁶⁸UMLS
See all MalaCards sources

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever ¹¹ ⁵⁴ ² ¹³

Hemorrhagic Fever, Crimean ³⁹ ⁶⁸

Crimean Hemorrhagic Fever ¹¹ ⁵⁴

Congo Hemorrhagic Fever ⁵⁴ ⁶⁸

Cchf ⁵⁴ ²

Congo-Crimean Hemorrhagic Fever ¹¹

Hemorrhagic Fever Crimean-Congo ⁵⁰

Chf Congo Virus ¹¹

Congo Fever ⁵⁴

Characteristics:

Orphanet epidemiological data:

⁵⁴

crimean-congo hemorrhagic fever:
Age of onset: All ages; Age of death: any age

Classifications:

MalaCards categories:
Global: Genetic diseases, Infectious diseases, Rare diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³⁰

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Other viral haemorrhagic fevers, not elsewhere classified

Crimean-Congo haemorrhagic fever

Orphanet: ⁵⁴

Rare infectious diseases

External Ids:

Disease Ontology¹¹ DOID:12287

ICD10³⁰ A98.0

ICD9CM³² 065.0

MeSH³⁹ D006479

SNOMED-CT⁶² 43489008

NCIt⁴⁵ C34682

Orphanet⁵⁴ ORPHA99827

ICD10 via Orphanet³¹ A98.0

UMLS⁶⁸ C0019099

Summaries for Crimean-Congo Hemorrhagic Fever

Sources:
¹¹Disease Ontology, ³⁶MalaCards
See all MalaCards sources

Disease Ontology:¹¹ A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to hemophagocytic lymphohistiocytosis and malaria, and has symptoms including abnormality of temperature regulation, skin rash and hepatic steatosis. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways are Cytokines and Inflammatory Response and African trypanosomiasis. Affiliated tissues include eye, skin and testes, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Related Diseases for Crimean-Congo Hemorrhagic Fever

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)

id	Related Disease	Score	Top Affiliating Genes
1	hemophagocytic lymphohistiocytosis	30.5	IL6, TNF
2	malaria	28.5	CXCL10, F3, IL6, TNF, VEGFA
3	hemorrhagic fever	11.4
4	idiopathic central precocious puberty	10.4	F3, TNF
5	chronic diarrhea due to guanylate cyclase 2c overactivity	10.4	F3, IL6
6	panner disease	10.4	IL6, TNF
7	aortic arch interruption	10.4	IL6, TNF
8	maligant granulosa cell tumor of ovary	10.4	IL6, TNF
9	hemometra	10.4	IL6, TNF
10	tricho odonto onycho dermal syndrome	10.4	IL6, TNF
11	scrotum paget's disease	10.4	IL6, TNF
12	epstein-barr virus hepatitis	10.4	IL6, TNF
13	abdominal chemodectomas with cutaneous angiolipomas	10.4	IL6, TNF
14	antigen-peptide-transporter 2 deficiency	10.4	IL6, TNF
15	hypothyroidism	10.4	IL6, TNF
16	ethmoid sinus adenoid cystic carcinoma	10.4	IL6, TNF
17	splenic manifestation of prolymphocytic leukemia	10.4	IL6, TNF
18	post-infectious myocarditis	10.4	IL6, TNF
19	skin disease	10.4	IL6, TNF
20	pasteurellosis	10.4	IL6, TNF
21	scarlet fever	10.4	IL6, TNF
22	lymphocytic colitis	10.4	IL6, TNF
23	non-secretory myeloma	10.4	IL6, TNF
24	idiopathic neutropenia	10.4	F3, IL6
25	tonsillar fossa cancer	10.4	CASP3, IL6
26	sweat gland cancer	10.4	F3, IL6
27	qualitative platelet defect	10.4	IL6, TNF
28	sterility due to immotile flagella	10.4	IL6, TNF
29	islet cell tumor	10.4	IL6, TNF
30	rift valley fever	10.4
31	ulcerative colitis	10.4	CASP3, IL6
32	orbital lymphangioma	10.4	IL6, TNF
33	cauda equina syndrome	10.4	IL6, TNF
34	renal cell carcinoma 4	10.4	IL6, TNF
35	nondystrophic myotonia	10.4	GPT, TNF
36	paraneoplastic polyneuropathy	10.3	IL6, TNF
37	thoracic aortic aneurysm	10.3	IL6, TNF
38	steatorrhea	10.3	CXCL10, TNF
39	epididymis adenomatoid tumor	10.3	IL6, TNF
40	primary biliary cirrhosis	10.3	IL6, TNF
41	colon carcinoma in situ	10.3	F3, IL6
42	ampulla of vater neoplasm	10.3	IL6, TNF
43	leukostasis	10.3	IL6, TNF
44	mechanical lagophthalmos	10.3	IL6, TNF
45	oral candidiasis	10.3	IL6, TNF
46	foodborne botulism	10.3	IL6, TNF
47	psychologic dyspareunia	10.3	CXCL10, TNF
48	gastroduodenal crohn's disease	10.3	IL6, TNF
49	substernal goiter	10.3	CXCL10, IL6
50	endotheliitis	10.3

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

Sources:
¹¹Disease Ontology, ⁴¹MGI, ⁵⁴Orphanet, ⁶⁴The Human Phenotype Ontology, ⁶⁸UMLS
See all MalaCards sources

Symptoms:

¹¹ (show all 13)

• headache
• high fever
• back pain
• joint pain
• stomach pain
• vomiting
• red eyes

• flushed face
• red throat
• petechiae (red spots) on the palate
• jaundice
• nosebleeds
• blood in the feces

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

⁶⁴ ⁵⁴ (show all 29)

id	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	abnormality of temperature regulation⁶⁴	hallmark (90%)		HP:0004370
2	skin rash⁶⁴ ⁵⁴	typical (50%)	Frequent (79-30%)	HP:0000988
3	hepatic steatosis⁶⁴ ⁵⁴	typical (50%)	Frequent (79-30%)	HP:0001397
4	subcutaneous hemorrhage⁶⁴	typical (50%)		HP:0001933
5	diarrhea⁶⁴ ⁵⁴	typical (50%)	Frequent (79-30%)	HP:0002014
6	nausea and vomiting⁶⁴ ⁵⁴	typical (50%)	Frequent (79-30%)	HP:0002017
7	abdominal pain⁶⁴ ⁵⁴	typical (50%)	Frequent (79-30%)	HP:0002027
8	migraine⁶⁴	typical (50%)		HP:0002076
9	elevated hepatic transaminases⁶⁴ ⁵⁴	typical (50%)	Frequent (79-30%)	HP:0002910
10	myalgia⁶⁴ ⁵⁴	typical (50%)	Frequent (79-30%)	HP:0003326
11	inflammatory abnormality of the eye⁶⁴	typical (50%)		HP:0100533
12	recurrent pharyngitis⁶⁴ ⁵⁴	typical (50%)	Frequent (79-30%)	HP:0100776
13	gingival bleeding⁶⁴ ⁵⁴	occasional (7.5%)	Occasional (29-5%)	HP:0000225
14	epistaxis⁶⁴ ⁵⁴	occasional (7.5%)	Occasional (29-5%)	HP:0000421
15	sudden cardiac death⁶⁴	occasional (7.5%)		HP:0001645
16	thrombocytopenia⁶⁴ ⁵⁴	occasional (7.5%)	Occasional (29-5%)	HP:0001873
17	leukopenia⁶⁴ ⁵⁴	occasional (7.5%)	Occasional (29-5%)	HP:0001882
18	abnormality of coagulation⁶⁴	occasional (7.5%)		HP:0001928
19	gastrointestinal hemorrhage⁶⁴ ⁵⁴	occasional (7.5%)	Occasional (29-5%)	HP:0002239
20	chest pain⁶⁴ ⁵⁴	occasional (7.5%)	Occasional (29-5%)	HP:0100749
21	uveitis⁵⁴		Frequent (79-30%)
22	jaundice⁵⁴		Occasional (29-5%)
23	petechiae⁵⁴		Frequent (79-30%)
24	abnormal bleeding⁵⁴		Occasional (29-5%)
25	fever⁵⁴		Very frequent (99-80%)
26	headache⁵⁴		Frequent (79-30%)
27	cardiorespiratory arrest⁵⁴		Occasional (29-5%)
28	fatigue⁵⁴		Very frequent (99-80%)
29	cough⁵⁴		Frequent (79-30%)

UMLS symptoms related to Crimean-Congo Hemorrhagic Fever:

hemoptysis, cullen's sign, traumatic hematuria, mucosal haemorrhage, nail bed hemorrhage

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	8.6	CASP3, IL6, NFKB1, TNF, VEGFA
2	cardiovascular system	MP:0005385	8.4	CASP3, CXCL10, F3, IL6, TNF, VEGFA
3	integument	MP:0010771	8.2	CASP3, F3, IL6, NFKB1, TNF, VEGFA
4	muscle	MP:0005369	8.2	CASP3, F3, IL6, NFKB1, TNF, VEGFA
5	cellular	MP:0005384	7.8	CASP3, CXCL10, F3, IL6, NFKB1, TNF
6	respiratory system	MP:0005388	7.8	CASP3, IL6, NFKB1, TNF, VEGFA
7	nervous system	MP:0003631	7.7	CASP3, CXCL10, F3, IL6, NFKB1, TNF
8	homeostasis/metabolism	MP:0005376	7.4	CASP3, CXCL10, F3, IL6, NFKB1, TLR8
9	immune system	MP:0005387	7.4	CASP3, CXCL10, F3, IL6, NFKB1, TLR8
10	hematopoietic system	MP:0005397	6.9	CASP3, CXCL10, F3, GPT, IL6, NFKB1

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Sources:
¹BitterDB, ⁴ClinicalTrials, ⁷Cochrane Library, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁴⁶NDF-RT, ⁵⁰Novoseek, ⁵⁶PharmGKB, ⁶⁸UMLS
See all MalaCards sources

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Ribavirin

approved

Phase 2

984

36791-04-5

37542

Synonyms:

1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide

36791-04-5

437710-49-1

66510-90-5

AA-504/07617051

AB00430481

AC1L1XXZ

AC1Q1IDC

AC1Q4ZGS

AKOS001715163

BB_NC-0567

BPBio1_001195

BRN 0892462

BSPBio_001085

BSPBio_003352

C-Virin

CHEMBL1643

CID37542

Copegus

Copegus (TN)

Cotronak

D00423

DB00811

DRG-0028

DivK1c_000782

Drug: Ribavirin

EU-0101063

FT-0082885

HMS2090L15

HMS2094O09

HMS502H04

HSDB 6513

ICN-1229

IDI1_000782

KBio1_000782

KBio2_002328

KBio2_004896

KBio2_007464

KBio3_002854

KBioGR_001804

KBioSS_002331

KS-1104

LS-1241

Lopac0_001063

MLS000028486

MLS002222317

MolPort-002-507-104

MolPort-002-885-856

NCGC00090726-01

NCGC00090726-03

NCGC00090726-04

NCGC00090726-05

NCGC00090726-06

NCGC00090726-07

NINDS_000782

NSC 163039

NSC163039

Prestwick3_000993

R 9644

R-964

R9644_SIGMA

RBV

RG-964

RIBAV

RTC

RTCA

RTP

Ravanex

Rebetol

Rebetol (TN)

Rebetron

Rebretron

Ribacine

Ribamide

Ribamidil

Ribamidyl

Ribasphere

Ribasphere (TN)

Ribav

Ribavirin

Ribavirin (JAN/USP/INN)

Ribavirin Capsules

Ribavirin Triphosphate

Ribavirin [USAN:INN]

Ribavirin-TP

Ribavirina

Ribavirina [INN-Spanish]

Ribavirine

Ribavirine [INN-French]

Ribavirinum

Ribavirinum [INN-Latin]

Ribovirin

Ro 20-9963/000

Ro-20-9963

S2504_Selleck

SCH 18908

SMP1_000261

SMR000058315

SPECTRUM1503938

SR-01000076112-3

Spectrum3_001876

Spectrum4_001252

Spectrum5_002075

Spectrum_001826

Tribavirin

UNII-49717AWG6K

Varazid

Vilona

Viramid

Viramide

Virazid

Virazide

Virazole

Virazole (Ribavirin) Inhalation Solution

Virazole (TN)

Virazole 5'-triphosphate

ZINC01035331

ribavirin

2

Antimetabolites

Phase 2

11774

3

Anti-Infective Agents

Phase 2

21402

4

Antiviral Agents

Phase 2

9732

5

Formaldehyde

approved, vet_approved

Phase 1

84

50-00-0

712

Synonyms:

Aldeide formica

Fannoform

Formaldehyde

Formalin

Formalina

Formaline

Formalith

Formic aldehyde

Formol

Methaldehyde

Methanal

Methyl aldehyde

Methylene glycol

Methylene oxide

Oxomethane

Oxomethylene

Oxymethylene

Paraform

Paraformaldehyde

6

Vaccines

Phase 1

6428

7

Pharmaceutical Solutions

Phase 1

7793

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities	Enrolling by invitation	NCT00992693	Phase 2
2	Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans	Active, not recruiting	NCT03020771	Phase 1
3	Cohort of Patients Infected by an Arbovirus	Recruiting	NCT01099852
4	Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever	Not yet recruiting	NCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

³⁶

Eye, Skin, Testes, Endothelial, Heart, Neutrophil

Publications for Crimean-Congo Hemorrhagic Fever

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 498)

id	Title	Authors	Year
1	Crimean-Congo hemorrhagic fever among children in Iran. (27878461)	Aslani D.... Fazlalipour M.	2016
2	Does Crimean-Congo Hemorrhagic Fever Cause a Vasculitic Reaction with Pulmonary Artery Enlargement and Acute Pulmonary Hypertension? (27344326)	AktaA9 T.... Kaya T.	2016
3	Crimean-Congo Hemorrhagic Fever in Dubai, United Arab Emirates, 2010: Case Report. (27795839)	Mohamed Al Dabal L.... Alwan A.M.	2016
4	Possible sexual transmission of Crimean-Congo hemorrhagic fever. (26972040)	Pshenichnaya N.Y.... Zhuravlev A.S.	2016
5	Crimean-Congo hemorrhagic fever - A ticking bomb? (27044612)	Al-Abri S.S.... Petersen E.	2016
6	Crimean-Congo hemorrhagic fever virus lineages Europe 1 and Europe 2 in Bulgarian ticks. (27378409)	Panayotova E.... Christova I.	2016
7	Current situation of Crimean-Congo hemorrhagic fever in Southeastern Europe and neighboring countries: a public health risk for the European Union? (27044611)	Dreshaj S.... Dedushaj I.	2016
8	The first fatal case of Crimean-Congo Hemorrhagic Fever due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus. (26902209)	Salehi-Vaziri M.... Fazlalipour M.	2016
9	Crimean-Congo Hemorrhagic Fever Knowledge, Attitudes, Practices, Risk Factors, and Seroprevalence in Rural Georgian Villages with Known Transmission in 2014. (27336731)	Greiner A.L.... Salyer S.J.	2016
10	Crimean-Congo Hemorrhagic Fever Virus IgG in Goats, Bhutan. (27088568)	Wangchuk S.... Tenzin T.	2016
11	Serum sTREM-1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection. (26877157)	Altay F.A.... A9encan A.^.	2016
12	Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran. (27308275)	Champour M.... Jalali T.	2016
13	Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. (27353580)	Gazi H.... Horasan G.D.	2016
14	Molecular Assay on Crimean Congo Hemorrhagic Fever Virus in Ticks (Ixodidae) Collected from Kermanshah Province, Western Iran. (27308296)	Mohammadian M.... Farhadpour F.	2016
15	A child with an unusual complication of Crimean-Congo hemorrhagic fever: Hemorrhagic pleural effusion. (27004585)	Sahin I.O.... Arslan M.	2016
16	Examination of the specific clinical symptoms and laboratory findings of Crimean-Congo hemorrhagic fever. (27353587)	Kilinc C.... Menekse E.	2016
17	Heat Shock Protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle. (27512070)	Surtees R.... Barr J.N.	2016
18	Determination of nasal mucociliary clearance time and nasal symptom in patients with crimean-congo hemorrhagic fever. (27813123)	DurmuA9 K.... Altuntas E.E.	2016
19	Biosafety standards for working with Crimean-Congo hemorrhagic fever virus. (27667586)	Weidmann M.... Zeller H.	2016
20	Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana. (27392037)	Akuffo R.... Dueger E.	2016
21	Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system. (26935918)	Suda Y.... Shimojima M.	2016
22	Crimean-Congo Hemorrhagic Fever with Acute Subdural Hematoma, Mauritania, 2012. (27315138)	Kleib A.S.... Bettar E.S.	2016
23	Sero-epidemiological survey of Crimean-Congo hemorrhagic fever virus in Tunisia. (26956221)	Wasfi F.... Letaief A.	2016
24	The prognostic significance of serum TGF-I^1 levels in patients with Crimean-Congo hemorrhagic fever. (27467498)	Yilmaz G.... KAPksal A.^.	2016
25	Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever. (27378224)	Akinci E.... Leblebicioglu H.	2016
26	Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity. (27775001)	Xia H.... Bente D.A.	2016
27	Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. (27666016)	Wang X.... Lou Z.	2016
28	Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area. (27677379)	Tanyel E.... Leblebicioglu H.	2016
29	Crimean-Congo hemorrhagic fever with hyperbilirubinemia and ascites: An unusual presentation. (26129885)	Ture Z.... YaA9cA+-A8aA9layA+k D.	2016
30	Novel, In-House, SYBR Green Based One-Step rRT-PCR: Rapid and Accurate Diagnosis of Crimean-Congo Hemorrhagic Fever Virus in Suspected Patients From Iran. (27099688)	Zahraei B.... Dorostkar R.	2016
31	Molecular analysis of Crimean-Congo hemorrhagic fever virus and Rickettsia in Hyalomma marginatum ticks removed from patients (Spain) and birds (Spain and Morocco), 2009-2015. (27215620)	Palomar A.M.... Oteo J.A.	2016
32	A retrospective controlled study of thiol disulfide homeostasis as a novel marker in Crimean Congo hemorrhagic fever. (27159644)	Tufan Z.K.... Guner R.	2016
33	Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. (27110812)	Zivcec M.... Bergeron A.8.	2016
34	The prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever. (27089100)	Yilmaz H.... KAPksal A.^.	2016
35	Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses. (27217069)	MA1ller M.A.... Drosten C.	2016
36	Clinical severity in forecasting platelet to lymphocyte ratio in Crimean-Congo hemorrhagic fever patients. (27501696)	Eren S.H.... GAPzel M.G.	2016
37	Molecular epidemiology of Crimean-Congo hemorrhagic fever virus detected from ticks of one humped camels (Camelus dromedarius) population in northeastern Iran. (27065608)	Champour M.... Jalali T.	2016
38	Multi-center prospective evaluation of discharge criteria for hospitalized patients with Crimean-Congo Hemorrhagic Fever. (27424492)	Leblebicioglu H.... Ozaras R.	2016
39	Epidemiological Survey of Crimean-Congo Hemorrhagic Fever (CCHF), a Fatal Infectious Disease in Khuzestan Province, Southwest Iran, During 1999 - 2015. (27540454)	Sharififard M.... Kamali A.	2016
40	Crimean-Congo Hemorrhagic Fever Virus in Bulgaria and Turkey. (27467142)	Mertens M.... Groschup M.H.	2016
41	Phylogeography of Crimean Congo Hemorrhagic Fever Virus. (27880794)	Lukashev A.N.... Gmyl A.P.	2016
42	A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus. (27713073)	SPENGLER J.R.... Bente D.A.	2016
43	Protective role of host aquaporin 6 against Hazara virus, a model for Crimean-Congo hemorrhagic fever virus infection. (26976854)	Molinas A.... VikstrAPm E.	2016
44	A competitive ELISA for species-independent detection of Crimean-Congo hemorrhagic fever virus specific antibodies. (27623345)	Schuster I.... Groschup M.H.	2016
45	Phylogeny of tick-derived Crimean-Congo hemorrhagic fever virus strains in Iran. (27491289)	Biglari P.... Shahhosseini N.	2016
46	PRESEPSIN LEVELS OF PATIENTS WITH CRIMEAN-CONGO HEMORRHAGIC FEVER. (27000451)	DemirpenAse A.9.... BakA+r M.	2016
47	Thorax CT findings in patients with Crimean-Congo hemorrhagic fever (CCHF). (27818861)	AktaA9 T.... Demir O.	2016
48	Crimean Congo Hemorrhagic Fever Virus and Alkhurma (Alkhumra) Virus in Ticks in Djibouti. (27508862)	Horton K.C.... Dueger E.L.	2016
49	Seroprevalence of Crimean-Congo hemorrhagic fever in Turkey's Van Province. (27169950)	Bayram Y.... Andac C.A.	2016
50	MicroRNA expression profiles in patients with acute Crimean Congo Hemorrhagic Fever reveal possible adjustments to cellular pathways. (27551771)	Demir Z.C.... Ozkul A.	2016

Genes related to Crimean-Congo Hemorrhagic Fever

Sources:
¹³DISEASES, ²¹GeneCards
See all MalaCards sources

Genes related to Crimean-Congo Hemorrhagic Fever:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	F3	Coagulation Factor III, Tissue Factor	24.28	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
2	TNF	Tumor Necrosis Factor	22.34	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
3	TLR8	Toll Like Receptor 8	22.22	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
4	IL6	Interleukin 6	21.93	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
5	CXCL10	C-X-C Motif Chemokine Ligand 10	21.77	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
6	NFKB1	Nuclear Factor Kappa B Subunit 1	21.72	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
7	CASP3	Caspase 3	18.78	GeneCards inferred via : Publications (show sections)
8	VEGFA	Vascular Endothelial Growth Factor A	18.44	GeneCards inferred via : Publications (show sections)
9	GPT	Glutamic--Pyruvic Transaminase	18.44	GeneCards inferred via : Publications (show sections)

Variations for Crimean-Congo Hemorrhagic Fever

Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁸QIAGEN, ⁵⁹R&D Systems, ⁶⁰Reactome, ⁶⁵Thomson Reuters
See all MalaCards sources

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 44)

id	Super pathways	Score	Top Affiliating Genes
1	Cytokines and Inflammatory Response⁴²	9.7	IL6, TNF
2	African trypanosomiasis³⁴	9.7	IL6, TNF
3	Canonical NF-kappaB pathway⁴²	9.6	NFKB1, TNF
4	EBV LMP1 signaling⁴²	9.6	NFKB1, TNF
5	Immune response_IL-6 signaling pathway⁶⁵	9.5	IL6, NFKB1
6	14-3-3 and Regulation of BAD Activity⁵⁸	9.5	CASP3, TNF
7	IL27-mediated signaling events⁴² Show member pathways IL-12 Family Signaling Pathways⁵⁹ Th1 Differentiation Pathway⁵⁹	9.3	IL6, TLR8, TNF
8	G-protein signaling_RhoB regulation pathway⁶⁵	9.3	CXCL10, IL6, TNF
9	Toll Comparative Pathway⁵⁸ Show member pathways Immune response MIF in innate immunity response⁶⁵ IL-1 Pathway⁵⁸ iNOS Signaling⁵⁸ TLR-TRIF Pathway⁵⁸	9.2	IL6, NFKB1, TNF
10	amb2 Integrin signaling⁴²	9.2	IL6, NFKB1, TNF
11	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways⁶⁰ Show member pathways Inflammasomes⁶⁰ The AIM2 inflammasome⁶⁰ NOD1/2 Signaling Pathway⁶⁰ The NLRP3 inflammasome⁶⁰ The NLRP1 inflammasome⁶⁰	9.2	IL6, NFKB1, TNF
12	IgA-Producing B Cells in the Intestine⁵⁹	9.2	IL6, NFKB1, TNF
13	Immune response_MIF-mediated glucocorticoid regulation⁶⁵	9.2	IL6, NFKB1, TNF
14	IL-10 Pathway⁵⁸	9.2	IL6, NFKB1, TNF
15	Toxoplasmosis³⁴ Show member pathways Leishmaniasis³⁴	9.0	CASP3, NFKB1, TNF
16	Ceramide Pathway⁵⁸ Show member pathways TNF-Induced Apoptosis Implicating Sphingolipids⁵⁸	9.0	CASP3, NFKB1, TNF
17	LPA receptor mediated events⁴²	8.9	CASP3, IL6, NFKB1
18	Rheumatoid arthritis³⁴	8.9	IL6, TNF, VEGFA
19	NF-KappaB Family Pathway⁵⁸ Show member pathways NF-KappaB (p50-p65) Pathway⁵⁸	8.8	IL6, NFKB1, TLR8, TNF
20	NF-kappaB Signaling³	8.8	CXCL10, NFKB1, TLR8, TNF
21	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways⁶⁰ Show member pathways TRAF3-dependent IRF activation pathway⁶⁰ TRAF6 mediated IRF7 activation⁶⁰ Negative regulators of RIG-I/MDA5 signaling⁶⁰ RIG-I-like receptor signaling pathway³⁴ RIG-I-like Receptor (RLR) Signaling Pathways⁵⁹ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10⁶⁰ Cytosolic DNA-sensing pathway³⁴	8.7	CXCL10, IL6, NFKB1, TNF
22	HIF-1 signaling pathway³⁴	8.7	IL6, NFKB1, VEGFA
23	Proteoglycans in cancer³⁴	8.7	CASP3, TNF, VEGFA
24	Spinal Cord Injury⁴²	8.6	CASP3, CXCL10, IL6, TNF
25	Allograft rejection⁴² ³⁴ Show member pathways Allograft Rejection⁴² Viral myocarditis³⁴ Asthma³⁴ CTL Mediated Apoptosis⁵⁸ Intestinal immune network for IgA production³⁴ Graft-versus-host disease³⁴ Autoimmune thyroid disease³⁴ Type I diabetes mellitus³⁴ THC Differentiation Pathway⁵⁸ Antigen processing and presentation³⁴	8.6	CASP3, IL6, NFKB1, TNF
26	Legionellosis³⁴	8.6	CASP3, IL6, NFKB1, TNF
27	Tuberculosis³⁴	8.6	CASP3, IL6, NFKB1, TNF
28	Amoebiasis³⁴	8.6	CASP3, IL6, NFKB1, TNF
29	Pertussis³⁴	8.6	CASP3, IL6, NFKB1, TNF
30	Integrated Breast Cancer Pathway⁴²	8.5	CASP3, NFKB1, VEGFA
31	Toll-Like receptor Signaling Pathways⁵⁹ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways⁵⁹ Immune response IL-1 signaling pathway⁶⁵ NOD-like receptor signaling pathway³⁴ Mucin expression in CF via TLRs, EGFR signaling pathways⁶⁵ IL-1 Family Signaling Pathways⁵⁹ Inflammasome Activation Pathways⁵⁹ NOD-like Receptor Signaling Pathways⁵⁹ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway⁶⁵	8.5	F3, IL6, NFKB1, TLR8, TNF
32	Bacterial infections in CF airways⁶⁵ Show member pathways IL-1 beta-dependent CFTR expression⁶⁵ Immune response Bacterial infections in normal airways⁶⁵ Immune response TLR signaling pathways⁶⁵	8.4	CXCL10, IL6, NFKB1, TLR8, TNF
33	Integrated Pancreatic Cancer Pathway⁴²	8.2	CASP3, NFKB1, TNF, VEGFA
34	Influenza A³⁴ Show member pathways Herpes simplex infection³⁴ Measles³⁴	8.1	CASP3, CXCL10, IL6, NFKB1, TNF
35	PAK Pathway⁵⁸ Show member pathways Epithelial Adherens Junctions⁵⁸ Antioxidant Action of Vitamin-C⁵⁸	8.1	CASP3, CXCL10, IL6, NFKB1, TNF
36	TNF signaling pathway³⁴	8.1	CASP3, CXCL10, IL6, NFKB1, TNF
37	Pathways in cancer³⁴	8.1	CASP3, IL6, NFKB1, VEGFA
38	TRAF Pathway⁵⁸ Show member pathways Toll-Like Receptors Pathway⁵⁸ TNF Superfamily Pathway⁵⁸ 14-3-3 Induced Apoptosis⁵⁸	7.8	CASP3, NFKB1, TLR8, TNF, VEGFA
39	SIDS Susceptibility Pathways⁴²	7.8	CASP3, IL6, NFKB1, TNF, VEGFA
40	Akt Signaling⁵⁸ Show member pathways p38 Signaling⁵⁸ Tec Kinases Signaling⁵⁸	7.7	CASP3, CXCL10, IL6, NFKB1, TLR8, TNF
41	Toll-like receptor signaling pathway³⁴ ⁴² Show member pathways Hepatitis B³⁴ Chagas disease (American trypanosomiasis)³⁴ Regulation of toll-like receptor signaling pathway⁴²	7.7	CASP3, CXCL10, IL6, NFKB1, TLR8, TNF
42	AGE-RAGE signaling pathway in diabetic complications³⁴	7.4	CASP3, F3, IL6, NFKB1, TNF, VEGFA
43	Colorectal Cancer Metastasis⁵⁸	7.4	CASP3, IL6, NFKB1, TLR8, TNF, VEGFA
44	PEDF Induced Signaling⁵⁸ Show member pathways Glucocorticoid Receptor Signaling⁵⁸ Cytokine-cytokine receptor interaction³⁴ Endothelin-1 Signaling Pathway⁵⁸ STAT3 Pathway⁵⁸ IL-6 Pathway⁵⁸ PGC1Alpha Pathway⁵⁸ NFAT Signaling and Lymphocyte Interactions⁵⁸ MIF Regulation of Innate Immune Cells⁵⁸ MIF Mediated Glucocorticoid Regulation⁵⁸ RAR-Gamma-RXR-Alpha Degradation⁵⁸ all-trans-Retinoic Acid Signaling in Brain⁵⁸	7.3	CASP3, CXCL10, IL6, NFKB1, TNF, VEGFA

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	10.0	CXCL10, IL6, TNF
2	extracellular space	GO:0005615	7.6	CXCL10, F3, GPT, IL6, TNF, VEGFA

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of interleukin-8 biosynthetic process	GO:0045416	10.5	TLR8, TNF
2	epithelial cell proliferation involved in salivary gland morphogenesis	GO:0060664	10.5	IL6, TNF
3	negative regulation of lipid storage	GO:0010888	10.5	IL6, TNF
4	positive regulation of chemokine production	GO:0032722	10.5	IL6, TNF
5	negative regulation of myoblast differentiation	GO:0045662	10.4	CXCL10, TNF
6	cellular response to nicotine	GO:0071316	10.4	NFKB1, TNF
7	response to auditory stimulus	GO:0010996	10.2	CXCL10, IL6
8	positive regulation of protein kinase B signaling	GO:0051897	10.1	F3, IL6, TNF
9	response to antibiotic	GO:0046677	10.1	CASP3, IL6
10	positive regulation of positive chemotaxis	GO:0050927	10.1	F3, VEGFA
11	positive regulation of protein complex assembly	GO:0031334	10.0	TNF, VEGFA
12	defense response to virus	GO:0051607	10.0	CXCL10, IL6, TLR8
13	I-kappaB kinase/NF-kappaB signaling	GO:0007249	10.0	NFKB1, TLR8, TNF
14	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	10.0	CASP3, F3, TNF
15	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.9	IL6, NFKB1, TNF
16	regulation of cell proliferation	GO:0042127	9.9	CXCL10, IL6, TNF
17	response to glucocorticoid	GO:0051384	9.7	CASP3, IL6, TNF
18	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.6	IL6, TNF, VEGFA
19	positive regulation of cell migration	GO:0030335	9.6	CXCL10, F3, VEGFA
20	cellular response to lipopolysaccharide	GO:0071222	9.5	CXCL10, IL6, NFKB1, TNF
21	response to virus	GO:0009615	9.3	CXCL10, TLR8, TNF
22	response to lipopolysaccharide	GO:0032496	9.2	CASP3, CXCL10, F3, IL6
23	inflammatory response	GO:0006954	9.1	CXCL10, IL6, NFKB1, TLR8, TNF
24	negative regulation of apoptotic process	GO:0043066	8.8	CASP3, IL6, NFKB1, VEGFA
25	positive regulation of transcription from RNA polymerase II promoter	GO:0045944	8.6	CXCL10, IL6, NFKB1, TNF, VEGFA