CCHF
MCID: CRM001
MIFTS: 54

Crimean-Congo Hemorrhagic Fever (CCHF) malady

Infectious diseases, Rare diseases categories
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Summaries for Crimean-Congo Hemorrhagic Fever

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8Disease Ontology, 4CDC, 33MalaCards
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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, has material basis in crimean-congo hemorrhagic fever virus, which is transmitted by hyalomma ticks. the infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards: Crimean-Congo Hemorrhagic Fever, also known as crimean hemorrhagic fever, is related to thrombocytopenia and malaria, and has symptoms including jaundice, joint pain and vomiting. An important gene associated with Crimean-Congo Hemorrhagic Fever is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are TRAF Pathway and Toll Like Receptor 7/8 (TLR7/8) Cascade. The compounds fibrinogen and neopterin have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related mouse phenotype immune system.

CDC:4 Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was first characterized in the Crimea in 1944 and given the name Crimean hemorrhagic fever. It was then later recognized in 1969 as the cause of illness in the Congo, thus resulting in the current name of the disease.

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

49
crimean-congo hemorrhagic fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

crimean-congo hemorrhagic fever 8 10 49
crimean hemorrhagic fever 8 49
congo hemorrhagic fever 49 62
congo-crimean hemorrhagic fever 8
hemorrhagic fever crimean-congo 45
hemorrhagic fever, crimean 62
chf congo virus 8
congo fever 49
cchf 49


External Ids:

Disease Ontology8 DOID:12287
ICD9CM27 065.0
NCIt40 C34682
MeSH35 D006479
SNOMED-CT58 43489008
ICD10 via Orphanet26 A98.0
SNOMED-CT via Orphanet59 43489008
ICD1025 A98.0

Related Diseases for Crimean-Congo Hemorrhagic Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Symptoms for Crimean-Congo Hemorrhagic Fever

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8Disease Ontology
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Symptoms:

8 (show all 37)
  • jaundice
  • joint pain
  • vomiting
  • headache
  • liver/hepatic steatosis
  • leukopenia/hypoleukocytosis
  • stomach pain
  • back pain
  • high fever
  • nosebleeds
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • blood in the feces
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • acute diarrhea
  • cough
  • thoracic/chest pain
  • cutaneous rash
  • hepatitis/icterus/cholestasis
  • fever/chilling
  • asthenia/fatigue/weakness
  • early death/lethality
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • myalgia/muscular pain
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • epistaxis/nose bleeding
  • pharyngitis
  • abnormal hepatic enzymes/transaminases
  • purpura/petichiae
  • facial pain/cephalalgia/migraine
  • thrombocytopenia/thrombopenia
  • gingivorrhagia/gingival bleeding
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Crimean-Congo Hemorrhagic Fever

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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33MalaCards
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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

33
Eye, Liver, Testes, Endothelial, Heart

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2F3, CHIT1, TLR9, TLR8

Publications for Crimean-Congo Hemorrhagic Fever

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52PubMed
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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 382)
idTitleAuthorsYear
1
Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011. (23195573)
2013
2
Evaluation of Crimean-Congo hemorrhagic fever virus infection in children. (24107215)
2013
3
Infection and propagation of Crimean-Congo hemorrhagic fever virus in embryonated chicken eggs. (23352881)
2013
4
Epidemiologic features and risk factors of Crimean-Congo hemorrhagic fever in Samsun province, Turkey. (23208513)
2013
5
Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever. (24270136)
2013
6
Influence of laboratory animal hosts on the life cycle of Hyalomma marginatum and implications for an in vivo transmission model for Crimean-Congo hemorrhagic fever virus. (23971007)
2013
7
Temporal modeling of Crimean-Congo hemorrhagic fever in eastern Iran. (23474177)
2013
8
Bayesian phylogeography of crimean-congo hemorrhagic Fever virus in europe. (24223988)
2013
9
Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)
2013
10
Comparative study between Ribavirin and Ribavirin plus Intravenous Immunoglobulin against Crimean Congo hemorrhagic fever. (24250699)
2013
11
The role of heparan sulphate in pathogenesis of Crimean-Congo hemorrhagic fever disease. (23995315)
2013
12
Factors associated with IgG positivity to Crimean-Congo hemorrhagic fever virus in the area with the highest seroprevalence in Greece. (23831367)
2013
13
Guineafowl, ticks and Crimean-Congo hemorrhagic fever in Turkey: the perfect storm? (23206535)
2013
14
Hepatocyte pathway alterations in response to in vitro Crimean Congo hemorrhagic fever virus infection. (24184319)
2013
15
Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya. (22925021)
2012
16
Crimean-Congo hemorrhagic fever virus in various ixodid tick species from a highly endemic area. (22119389)
2012
17
C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever. (22695238)
2012
18
Relationship between Crimean-Congo hemorrhagic fever virus strains circulating in Iran and Turkey: possibilities for transborder transmission. (22925023)
2012
19
Bradycardia in a patient with Crimean-Congo hemorrhagic fever related to ribavirin treatment. (23135017)
2012
20
Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey. (22192531)
2012
21
Species distribution and detection of Crimean Congo Hemorrhagic Fever Virus (CCHFV) in field-collected ticks in Ankara Province, Central Anatolia, Turkey. (21910017)
2012
22
Effect of oral ribavirin treatment on the viral load and disease progression in Crimean-Congo hemorrhagic fever. (21106428)
2011
23
Co-infection of Malaria and Crimean-Congo Hemorrhagic Fever. (22347306)
2011
24
Crimean-Congo hemorrhagic fever, Afghanistan, 2009. (22000377)
2011
25
Crimean-Congo hemorrhagic fever serosurvey in at-risk professionals, Madagascar, 2008 and 2009. (21889395)
2011
26
Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness. (20403306)
2010
27
Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. (20005156)
2010
28
Crimean-Congo hemorrhagic fever in Iran and neighboring countries. (20006541)
2010
29
Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran. (20854025)
2010
30
Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: a case-control study. (19168952)
2009
31
Ribavirin treatment for Crimean-Congo hemorrhagic fever. (20058332)
2009
32
A case of Crimean-congo hemorrhagic fever with pleural effusion. (19168966)
2009
33
A case of nosocomial transmission of Crimean-Congo hemorrhagic fever from patient to patient. (18948048)
2009
34
Modeling the spatial distribution of crimean-congo hemorrhagic fever outbreaks in Turkey. (18047397)
2007
35
Crimean-Congo hemorrhagic fever. (17762783)
2007
36
Identification of a novel C-terminal cleavage of Crimean-Congo hemorrhagic fever virus PreGN that leads to generation of an NSM protein. (17409136)
2007
37
Cytokine levels in Crimean-Congo hemorrhagic fever. (16765637)
2006
38
A variable region in the Crimean-Congo hemorrhagic fever virus L segment distinguishes between strains isolated from different geographic regions. (16372290)
2006
39
Crimean-Congo hemorrhagic fever in Southeast of Iran. (16182370)
2006
40
Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein. (16352575)
2006
41
Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment. (15033561)
2004
42
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. (12885882)
2003
43
Treatment and prophylaxis with ribavirin for Crimean-Congo Hemorrhagic Fever--is it effective? (12666854)
2003
44
Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus. (11980926)
2002
45
Isolation of Crimean-Congo hemorrhagic fever virus from ticks on imported Sudanese sheep in Saudi Arabia. (17322717)
2000
46
Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. (9392588)
1997
47
Replication and tissue tropisms of Crimean-Congo hemorrhagic fever virus in experimentally infected adult Hyalomma truncatum (Acari: Ixodidae). (1404255)
1992
48
Distribution of Crimean-Congo hemorrhagic fever viral antibody in Senegal: environmental and vectorial correlates. (2122750)
1990
49
Comparison of methods for isolation and titration of Crimean-Congo hemorrhagic fever virus. (3095367)
1986
50
Results of a preliminary seroepidemiological survey for Crimean-Congo hemorrhagic fever virus in Egypt. (25013)
1978

Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
50PathCards, 53QIAGEN, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 5Cell Signaling Technology, 60Thomson Reuters, 54R&D Systems, 61Tocris Bioscience
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Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1TLR8, TLR9
2
Show member pathways
9.1TLR9, TLR8
39.1TLR9, TLR8
4
Show member pathways
9.1TLR9, TLR8
5
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1TLR9, TLR8
69.1TLR9, TLR8
7
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1TLR8, TLR9
8
Show member pathways
IL27-mediated signaling events38
9.1TLR9, TLR8
99.1TLR9, TLR8
10
Show member pathways
9.1TLR8, TLR9
119.1TLR9, TLR8
12
Show member pathways
9.1TLR9, TLR8
13
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.6F3, TLR9, TLR8

Compounds for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank
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Compounds related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fibrinogen459.5F3, CHIT1
2neopterin459.5CHIT1, MX1
3imiquimod45 61 29 1112.4MX1, TLR8
4resiquimod45 6110.3TLR9, TLR8
5polysaccharide459.2F3, CHIT1
6endotoxin459.1F3, TLR9
7rantes458.9MX1, TLR9
8poly(i-c)458.7MX1, TLR9, TLR8

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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16Gene Ontology
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Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057649.2CHIT1, TLR9
2endolysosome membraneGO:0360209.1TLR9, TLR8
3endosome membraneGO:0100088.8TLR9, TLR8
4endoplasmic reticulum membraneGO:0057898.4MX1, TLR9, TLR8

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-alpha biosynthetic processGO:0453569.3TLR9, TLR8
2positive regulation of interferon-beta biosynthetic processGO:0453599.3TLR9, TLR8
3positive regulation of interferon-gamma biosynthetic processGO:0450789.3TLR9, TLR8
4toll-like receptor 9 signaling pathwayGO:0341629.2TLR9, TLR8
5response to virusGO:0096159.2MX1, TLR8
6toll-like receptor signaling pathwayGO:0022249.1TLR9, TLR8
7inflammatory responseGO:0069549.1TLR9, TLR8
8defense response to virusGO:0516079.0MX1, TLR8
9innate immune responseGO:0450878.6TLR8, TLR9, MX1

Products for genes affiliated with Crimean-Congo Hemorrhagic Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Crimean-Congo Hemorrhagic Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet