MCID: CRM001
MIFTS: 59

Crimean-Congo Hemorrhagic Fever malady

Categories: Genetic diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 2CDC, 47Novoseek, 65UMLS, 36MeSH, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 10 12 51 2
Hemorrhagic Fever, Crimean 36 65
Crimean Hemorrhagic Fever 10 51
Congo Hemorrhagic Fever 51 65
Cchf 51 2
 
Congo-Crimean Hemorrhagic Fever 10
Hemorrhagic Fever Crimean-Congo 47
Chf Congo Virus 10
Congo Fever 51

Characteristics:

Orphanet epidemiological data:

51
crimean-congo hemorrhagic fever:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:12287
ICD1027 A98.0
ICD9CM29 065.0
MeSH36 D006479
SNOMED-CT59 43489008
NCIt42 C34682
Orphanet51 99827
ICD10 via Orphanet28 A98.0
UMLS65 C0019099, C1304456

Summaries for Crimean-Congo Hemorrhagic Fever

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Disease Ontology:10 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to leptospirosis and malaria, and has symptoms including abnormality of temperature regulation, skin rash and hepatic steatosis. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways are Cytokines and Inflammatory Response and EBV LMP1 signaling. Affiliated tissues include eye, heart and t cells, and related mouse phenotypes are respiratory system and renal/urinary system.

Related Diseases for Crimean-Congo Hemorrhagic Fever

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Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1leptospirosis29.6IL6, TNF, VEGFA
2malaria28.3F3, IL6, TLR9, TNF, VEGFA
3hemorrhagic fever11.5
4hydronephrosis10.5CASP3, TNF
5rift valley fever10.5
6congenital dyserythropoietic anemia10.4IL6, MX1
7endotheliitis10.4
8congenital chloride diarrhea10.4F3, IL6
9plantar nerve lesion10.4IL6, TNF
10intermediate dend syndrome10.3IL6, TNF
11crohn's disease10.3IL6, TNF
12malignant sertoli-leydig cell tumor of ovary10.3IL6, TNF
13mammary paget's disease10.3IL6, TNF
14lujo hemorrhagic fever10.3IL6, TNF
15posterior valve urethra10.3IL6, TNF
16t cell immunodeficiency primary10.3IL6, TNF
17heterophyiasis10.3F3, IL6
18parovarian cyst10.3IL6, TNF
19precursor b lymphoblastic lymphoma/leukemia10.3IL6, TNF
20collagenous colitis10.3IL6, TNF
21early-onset, autosomal dominant alzheimer disease10.3IL6, TNF
22tick-borne encephalitis10.3
23encephalitis10.3
24skin conditions10.3IL6, TNF
25tick-borne relapsing fever10.3IL6, TNF
26postsurgical hypothyroidism10.3IL6, TNF
27streptococcal meningitis10.3IL6, TNF
28dancing eyes-dancing feet syndrome10.3IL6, TNF
29brain ischemia10.3CASP3, IL6
30hemolytic anemia10.3IL6, TNF
31diffuse intraductal papillomatosis10.3IL6, TNF
32rubeosis iridis10.3IL6, TNF
33ureteral disease10.3IL6, TNF
34duodenum cancer10.2IL6, TNF
35dentin caries10.2IL6, TNF
36placental abruption10.2IL6, TNF
37secretory diarrhea10.2IL6, TNF
38meige syndrome10.2IL6, TNF
39hypopharynx cancer10.2IL6, TNF
40west nile virus10.2
41hemophagocytic lymphohistiocytosis10.2
42thrombocytopenia10.2
43parotitis10.2
44thrombotic thrombocytopenic purpura10.2
45hemorrhagic fever with renal syndrome10.2
46cholecystitis10.2
47post-traumatic stress disorder10.2
48acalculous cholecystitis10.2
49acute pancreatitis10.2
50ischemia10.2

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Symptoms for Crimean-Congo Hemorrhagic Fever

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Symptoms:

 51 10 (show all 37)
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • cutaneous rash
  • purpura/petichiae
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • liver/hepatic steatosis
  • abnormal hepatic enzymes/transaminases
  • cough
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hepatitis/icterus/cholestasis
  • thoracic/chest pain
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • epistaxis/nose bleeding
  • gingivorrhagia/gingival bleeding
  • early death/lethality
  • headache
  • high fever
  • back pain
  • joint pain
  • stomach pain
  • vomiting
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • jaundice
  • nosebleeds
  • blood in the feces

HPO human phenotypes related to Crimean-Congo Hemorrhagic Fever:

(show all 20)
id Description Frequency HPO Source Accession
1 abnormality of temperature regulation hallmark (90%) HP:0004370
2 skin rash typical (50%) HP:0000988
3 hepatic steatosis typical (50%) HP:0001397
4 subcutaneous hemorrhage typical (50%) HP:0001933
5 diarrhea typical (50%) HP:0002014
6 nausea and vomiting typical (50%) HP:0002017
7 abdominal pain typical (50%) HP:0002027
8 migraine typical (50%) HP:0002076
9 elevated hepatic transaminases typical (50%) HP:0002910
10 myalgia typical (50%) HP:0003326
11 inflammatory abnormality of the eye typical (50%) HP:0100533
12 recurrent pharyngitis typical (50%) HP:0100776
13 gingival bleeding occasional (7.5%) HP:0000225
14 epistaxis occasional (7.5%) HP:0000421
15 sudden cardiac death occasional (7.5%) HP:0001645
16 thrombocytopenia occasional (7.5%) HP:0001873
17 leukopenia occasional (7.5%) HP:0001882
18 abnormality of coagulation occasional (7.5%) HP:0001928
19 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
20 chest pain occasional (7.5%) HP:0100749

UMLS symptoms related to Crimean-Congo Hemorrhagic Fever:


nail bed hemorrhage, mucosal haemorrhage, traumatic hematuria, cullen's sign, hemoptysis

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 294836791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
Ibavyr
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
Moderiba
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
 
NSC 163039
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribasphere Ribapak
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2Antiviral AgentsPhase 28071
3AntimetabolitesPhase 29454
4Anti-Infective AgentsPhase 217220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
3Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverNot yet recruitingNCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever


Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

33
Eye, Heart, T cells, Skin, Breast, Liver, Lung

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

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MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2CASP3, IL6, NFKB1, TNF, VEGFA
2MP:00053678.1CASP3, IL6, TLR8, TLR9, VEGFA
3MP:00107717.9CASP3, F3, IL6, NFKB1, TNF, VEGFA
4MP:00053817.6CASP3, IL6, NFKB1, TLR9, TNF, VEGFA
5MP:00053697.6CASP3, F3, IL6, NFKB1, TNF, VEGFA
6MP:00053847.2CASP3, F3, IL6, NFKB1, TLR9, TNF
7MP:00053766.8CASP3, F3, IL6, NFKB1, TLR8, TLR9
8MP:00053976.7CASP3, F3, IL6, NFKB1, TLR8, TLR9
9MP:00053876.4CASP3, F3, IL6, NFKB1, TLR8, TLR9

Publications for Crimean-Congo Hemorrhagic Fever

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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 469)
idTitleAuthorsYear
1
Possible sexual transmission of Crimean-Congo hemorrhagic fever. (26972040)
2016
2
Crimean-Congo hemorrhagic fever with hyperbilirubinemia and ascites: An unusual presentation. (26129885)
2016
3
Crimean-Congo hemorrhagic fever - A ticking bomb? (27044612)
2016
4
Reply: bradycardia with ribavirin therapy in crimean-congo hemorrhagic Fever. (25760574)
2015
5
Consensus report: Preventive measures for Crimean-Congo Hemorrhagic Fever during Eid-al-Adha festival. (26183413)
2015
6
Clinical significance of neutrophil gelatinase-associated lipocalin in Crimean-Congo hemorrhagic Fever. (25685783)
2015
7
Fiber-optic immunosensor for detection of Crimean-Congo hemorrhagic fever IgG antibodies in patients. (26151547)
2015
8
Cytokine concentrations in pediatric patients with crimean-congo hemorrhagic Fever. (25361408)
2014
9
A novel AP92-like Crimean-Congo hemorrhagic fever virus strain, Greece. (24953797)
2014
10
Prevalence of crimean-congo hemorrhagic Fever virus in healthy population, livestock and ticks in kosovo. (25393542)
2014
11
Serosurvey of Crimean-Congo hemorrhagic fever virus in domestic animals, Gujarat, India, 2013. (25229708)
2014
12
Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011. (23195573)
2013
13
Evaluation of Crimean-Congo hemorrhagic fever virus infection in children. (24107215)
2013
14
Infection and propagation of Crimean-Congo hemorrhagic fever virus in embryonated chicken eggs. (23352881)
2013
15
Epidemiologic features and risk factors of Crimean-Congo hemorrhagic fever in Samsun province, Turkey. (23208513)
2013
16
Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever. (24270136)
2013
17
Influence of laboratory animal hosts on the life cycle of Hyalomma marginatum and implications for an in vivo transmission model for Crimean-Congo hemorrhagic fever virus. (23971007)
2013
18
Temporal modeling of Crimean-Congo hemorrhagic fever in eastern Iran. (23474177)
2013
19
Bayesian phylogeography of crimean-congo hemorrhagic Fever virus in europe. (24223988)
2013
20
Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)
2013
21
Comparative study between Ribavirin and Ribavirin plus Intravenous Immunoglobulin against Crimean Congo hemorrhagic fever. (24250699)
2013
22
The role of heparan sulphate in pathogenesis of Crimean-Congo hemorrhagic fever disease. (23995315)
2013
23
Factors associated with IgG positivity to Crimean-Congo hemorrhagic fever virus in the area with the highest seroprevalence in Greece. (23831367)
2013
24
Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya. (22925021)
2012
25
Crimean-Congo hemorrhagic fever virus in various ixodid tick species from a highly endemic area. (22119389)
2012
26
C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever. (22695238)
2012
27
Relationship between Crimean-Congo hemorrhagic fever virus strains circulating in Iran and Turkey: possibilities for transborder transmission. (22925023)
2012
28
Effect of oral ribavirin treatment on the viral load and disease progression in Crimean-Congo hemorrhagic fever. (21106428)
2011
29
Co-infection of Malaria and Crimean-Congo Hemorrhagic Fever. (22347306)
2011
30
Crimean-Congo hemorrhagic fever, Afghanistan, 2009. (22000377)
2011
31
Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness. (20403306)
2010
32
Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. (20005156)
2010
33
Crimean-Congo hemorrhagic fever in Iran and neighboring countries. (20006541)
2010
34
Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran. (20854025)
2010
35
Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: a case-control study. (19168952)
2009
36
Ribavirin treatment for Crimean-Congo hemorrhagic fever. (20058332)
2009
37
A case of Crimean-congo hemorrhagic fever with pleural effusion. (19168966)
2009
38
Modeling the spatial distribution of crimean-congo hemorrhagic fever outbreaks in Turkey. (18047397)
2007
39
Crimean-Congo hemorrhagic fever. (17762783)
2007
40
Cytokine levels in Crimean-Congo hemorrhagic fever. (16765637)
2006
41
A variable region in the Crimean-Congo hemorrhagic fever virus L segment distinguishes between strains isolated from different geographic regions. (16372290)
2006
42
Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment. (15033561)
2004
43
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. (12885882)
2003
44
Treatment and prophylaxis with ribavirin for Crimean-Congo Hemorrhagic Fever--is it effective? (12666854)
2003
45
Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus. (11980926)
2002
46
Replication and tissue tropisms of Crimean-Congo hemorrhagic fever virus in experimentally infected adult Hyalomma truncatum (Acari: Ixodidae). (1404255)
1992
47
Distribution of Crimean-Congo hemorrhagic fever viral antibody in Senegal: environmental and vectorial correlates. (2122750)
1990
48
Comparison of methods for isolation and titration of Crimean-Congo hemorrhagic fever virus. (3095367)
1986
49
Results of a preliminary seroepidemiological survey for Crimean-Congo hemorrhagic fever virus in Egypt. (25013)
1978
50

Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL6, TNF
29.6NFKB1, TNF
39.6NFKB1, TNF
49.6CASP3, TNF
5
Show member pathways
9.2IL6, NFKB1, TNF
69.2IL6, NFKB1, TNF
7
Show member pathways
9.2IL6, NFKB1, TNF
89.2IL6, NFKB1, TNF
9
Show member pathways
9.2IL6, NFKB1, TNF
109.2IL6, NFKB1, TNF
11
Show member pathways
9.2IL6, TLR8, TLR9
129.2CASP3, IL6, TNF
139.2IL6, TLR9, TNF
149.2IL6, TLR9, TNF
159.2IL6, TLR9, TNF
16
Show member pathways
9.2NFKB1, TLR8, TLR9
17
Show member pathways
9.1CASP3, NFKB1, TNF
189.1CASP3, NFKB1, TNF
19
Show member pathways
9.1CASP3, NFKB1, TNF
209.1CASP3, IL6, NFKB1
219.1CASP3, IL6, NFKB1
22
Show member pathways
9.1IL6, MX1, TNF
238.9IL6, TNF, VEGFA
24
Show member pathways
8.8IL6, TLR8, TLR9, TNF
25
Show member pathways
8.7CASP3, IL6, NFKB1, TNF
268.7CASP3, IL6, NFKB1, TNF
27
Show member pathways
8.7CASP3, IL6, NFKB1, TNF
28
Show member pathways
8.7CASP3, IL6, NFKB1, TNF
298.7CASP3, IL6, NFKB1, TNF
308.7CASP3, IL6, NFKB1, TNF
318.7CASP3, IL6, NFKB1, TNF
328.7IL6, NFKB1, TLR9, TNF
338.7CASP3, NFKB1, VEGFA
348.5F3, IL6, NFKB1, VEGFA
35
Show member pathways
8.4IL6, NFKB1, TLR8, TLR9, TNF
36
Show member pathways
8.4IL6, NFKB1, TLR8, TLR9, TNF
378.3CASP3, IL6, TNF, VEGFA
388.3CASP3, NFKB1, TNF, VEGFA
398.3CASP3, IL6, NFKB1, VEGFA
40
Show member pathways
8.3CASP3, IL6, NFKB1, VEGFA
41
Show member pathways
8.3CASP3, NFKB1, TLR8, TLR9, TNF
428.2CASP3, IL6, NFKB1, TLR9, TNF
43
Show member pathways
8.0F3, IL6, NFKB1, TLR8, TLR9, TNF
44
Show member pathways
7.8CASP3, IL6, NFKB1, TLR8, TLR9, TNF
45
Show member pathways
7.8CASP3, IL6, NFKB1, TLR8, TLR9, TNF
467.6CASP3, F3, IL6, NFKB1, TNF, VEGFA
477.6CASP3, F3, IL6, NFKB1, TNF, VEGFA
48
Show member pathways
7.6CASP3, IL6, MX1, NFKB1, TLR9, TNF
49
Show member pathways
7.2CASP3, IL6, MX1, NFKB1, TLR8, TLR9
507.0CASP3, IL6, NFKB1, TLR8, TLR9, TNF

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:004541610.4TLR8, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4IL6, TNF
3positive regulation of nitric oxide biosynthetic processGO:004542910.3IL6, TNF
4cellular response to nicotineGO:007131610.3NFKB1, TNF
5regulation of cytokine secretionGO:005070710.3TLR8, TLR9
6negative regulation of lipid storageGO:001088810.2IL6, TNF
7positive regulation of NF-kappaB import into nucleusGO:004234610.2TLR9, TNF
8negative regulation of fat cell differentiationGO:004559910.2IL6, TNF
9response to antibioticGO:004667710.2CASP3, IL6
10negative regulation of interleukin-6 productionGO:003271510.1TLR9, TNF
11response to amino acidGO:004320010.0CASP3, IL6
12positive regulation of interleukin-6 productionGO:003275510.0IL6, TNF
13response to bacteriumGO:000961710.0IL6, NFKB1
14positive regulation of protein complex assemblyGO:003133410.0TNF, VEGFA
15defense response to Gram-negative bacteriumGO:00508299.9IL6, TLR9
16positive regulation of cell adhesionGO:00457859.7TNF, VEGFA
17response to glucocorticoidGO:00513849.7CASP3, IL6, TNF
18response to woundingGO:00096119.7CASP3, F3, IL6
19I-kappaB kinase/NF-kappaB signalingGO:00072499.7NFKB1, TLR8, TNF
20response to virusGO:00096159.6MX1, TLR8, TNF
21positive regulation of JUN kinase activityGO:00435079.6TLR9, TNF
22toll-like receptor signaling pathwayGO:00022249.5NFKB1, TLR8, TLR9
23MyD88-dependent toll-like receptor signaling pathwayGO:00027559.5NFKB1, TLR8, TLR9
24cellular response to lipopolysaccharideGO:00712229.5IL6, NFKB1, TNF
25activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.4CASP3, F3, TNF
26positive regulation of peptidyl-serine phosphorylationGO:00331389.3IL6, TNF, VEGFA
27inflammatory responseGO:00069549.1IL6, NFKB1, TLR8, TNF
28response to lipopolysaccharideGO:00324969.1CASP3, F3, IL6
29positive regulation of NF-kappaB transcription factor activityGO:00510929.0IL6, NFKB1, TLR9, TNF
30defense response to virusGO:00516078.8IL6, MX1, TLR8
31positive regulation of gene expressionGO:00106288.7IL6, TLR9, VEGFA
32negative regulation of apoptotic processGO:00430668.5CASP3, IL6, NFKB1, VEGFA

Sources for Crimean-Congo Hemorrhagic Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet