MCID: CRM001
MIFTS: 53

Crimean-Congo Hemorrhagic Fever malady

Categories: Genetic diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 2CDC, 47Novoseek, 65UMLS, 36MeSH, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 10 12 51 2
Hemorrhagic Fever, Crimean 36 65
Crimean Hemorrhagic Fever 10 51
Congo Hemorrhagic Fever 51 65
Cchf 51 2
 
Congo-Crimean Hemorrhagic Fever 10
Hemorrhagic Fever Crimean-Congo 47
Chf Congo Virus 10
Congo Fever 51

Characteristics:

Orphanet epidemiological data:

51
crimean-congo hemorrhagic fever:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:12287
ICD1027 A98.0
ICD9CM29 065.0
MeSH36 D006479
SNOMED-CT59 43489008
NCIt42 C34682
Orphanet51 99827
ICD10 via Orphanet28 A98.0
UMLS65 C0019099, C1304456

Summaries for Crimean-Congo Hemorrhagic Fever

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Disease Ontology:10 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to congenital chloride diarrhea and hemolytic anemia, and has symptoms including abnormality of temperature regulation, skin rash and hepatic steatosis. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways are Cytokines and Inflammatory Response and EBV LMP1 signaling. Affiliated tissues include eye, skin and lung, and related mouse phenotypes are respiratory system and renal/urinary system.

Related Diseases for Crimean-Congo Hemorrhagic Fever

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Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Symptoms for Crimean-Congo Hemorrhagic Fever

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Symptoms:

 51 10 (show all 37)
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • cutaneous rash
  • purpura/petichiae
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • liver/hepatic steatosis
  • abnormal hepatic enzymes/transaminases
  • cough
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hepatitis/icterus/cholestasis
  • thoracic/chest pain
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • epistaxis/nose bleeding
  • gingivorrhagia/gingival bleeding
  • early death/lethality
  • headache
  • high fever
  • back pain
  • joint pain
  • stomach pain
  • vomiting
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • jaundice
  • nosebleeds
  • blood in the feces

HPO human phenotypes related to Crimean-Congo Hemorrhagic Fever:

(show all 20)
id Description Frequency HPO Source Accession
1 abnormality of temperature regulation hallmark (90%) HP:0004370
2 skin rash typical (50%) HP:0000988
3 hepatic steatosis typical (50%) HP:0001397
4 subcutaneous hemorrhage typical (50%) HP:0001933
5 diarrhea typical (50%) HP:0002014
6 nausea and vomiting typical (50%) HP:0002017
7 abdominal pain typical (50%) HP:0002027
8 migraine typical (50%) HP:0002076
9 elevated hepatic transaminases typical (50%) HP:0002910
10 myalgia typical (50%) HP:0003326
11 inflammatory abnormality of the eye typical (50%) HP:0100533
12 recurrent pharyngitis typical (50%) HP:0100776
13 gingival bleeding occasional (7.5%) HP:0000225
14 epistaxis occasional (7.5%) HP:0000421
15 sudden cardiac death occasional (7.5%) HP:0001645
16 thrombocytopenia occasional (7.5%) HP:0001873
17 leukopenia occasional (7.5%) HP:0001882
18 abnormality of coagulation occasional (7.5%) HP:0001928
19 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
20 chest pain occasional (7.5%) HP:0100749

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RibavirinapprovedPhase 294836791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
Ibavyr
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
Moderiba
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
 
NSC 163039
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribasphere Ribapak
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
2Antiviral AgentsPhase 28071
3AntimetabolitesPhase 29454
4Anti-Infective AgentsPhase 217220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment FacilitiesEnrolling by invitationNCT00992693Phase 2
2Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
3Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic FeverNot yet recruitingNCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever


Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

33
Eye, Skin, Lung, Breast, Liver, Brain, Prostate

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

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MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2CASP3, IL6, NFKB1, TNF, VEGFA
2MP:00053678.1CASP3, IL6, TLR8, TLR9, VEGFA
3MP:00107717.9CASP3, F3, IL6, NFKB1, TNF, VEGFA
4MP:00053817.6CASP3, IL6, NFKB1, TLR9, TNF, VEGFA
5MP:00053697.6CASP3, F3, IL6, NFKB1, TNF, VEGFA
6MP:00053847.2CASP3, F3, IL6, NFKB1, TLR9, TNF
7MP:00053766.8CASP3, F3, IL6, NFKB1, TLR8, TLR9
8MP:00053976.7CASP3, F3, IL6, NFKB1, TLR8, TLR9
9MP:00053876.4CASP3, F3, IL6, NFKB1, TLR8, TLR9

Publications for Crimean-Congo Hemorrhagic Fever

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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 445)
idTitleAuthorsYear
1
Comment on the article 'Dysplasia epiphysealis hemimelica of the knee: an unusual presentation with intra-articular loose bodies and literature review' by Wheeldon and Altiok. (26035353)
2015
2
Unusual Manifestation of Graves' Disease: Ventricular Fibrillation. (26558239)
2015
3
Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation. (25609078)
2015
4
The metabolic and temporal basis of muscle hypertrophy in response to resistance exercise. (26289597)
2015
5
The outcome of complex regional pain syndrome type 1: a systematic review. (24530407)
2014
6
Pars plana vitrectomy in patients with myopic macular retinoschisis. (24414402)
2014
7
The variant of CD11b, rs1143679 within ITGAM, is associated with systemic lupus erythematosus and clinical manifestations in Brazilian patients. (24269694)
2014
8
Ideology and disease identity: the politics of rickets, 1929-1982. (23918817)
2013
9
Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study. (23778904)
2013
10
The impact of hyperglycemia on risk of infection and early death during induction therapy for acute lymphoblastic leukemia (ALL). (23868820)
2013
11
Medical treatment improves social behavior in a primate endometriosis model (Callithrix jacchus). (23432639)
2013
12
Dilatative Uropathy as a Manifestation of Neurohypophyseal Diabetes Insipidus due to a Novel Mutation in the Arginine Vasopressin-Neurophysin-II Gene. (24158882)
2013
13
Semantic processing impairment in individuals with schizotypal personality disorder features: a preliminary event-related potential study. (22960083)
2013
14
Do apolipoprotein E genotype and educational attainment predict the rate of cognitive decline in normal aging? A 12-year follow-up of the Maastricht Aging Study. (22642392)
2012
15
Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription. (22275273)
2012
16
Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inositol-3 kinase. (22363436)
2012
17
Prevalence of myopia in a population with malocclusions. (23046255)
2012
18
False-positive pericardial effusion due to breast attenuation on equilibrium radionuclide angiocardiography. (21565955)
2011
19
NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein. (21799007)
2011
20
Oxidative stress and platelet activation: markers of myocardial infarction in type 2 diabetes mellitus. (19759031)
2010
21
Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts. (20007285)
2010
22
Oral hairy leukoplakia in HIV-negative patients: report of 10 cases. (19033322)
2010
23
Does smoking cue-induced craving tell us anything important about nicotine dependence? (19426293)
2009
24
Effects of doxycycline on serum and endometrial levels of MMP-2, MMP-9 and TIMP-1 in women using a levonorgestrel-releasing subcutaneous implant. (19442784)
2009
25
Molecular characterization of avian infectious bronchitis virus strains from outbreaks in Argentina (2001-2008). (19322714)
2009
26
Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model. (18953525)
2009
27
Gamma 2 actin gene (enteric type) polymorphism is not associated with obstetric cholestasis or preeclampsia. (17934296)
2008
28
Paclitaxel-octreotide conjugates in tumor growth inhibition of A549 human non-small cell lung cancer xenografted into nude mice. (18983839)
2008
29
Melioidosis outbreak after typhoon, southern Taiwan. (17553230)
2007
30
Rosacea. (18183803)
2007
31
Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (16496371)
2006
32
3D QSAR studies on protein tyrosine phosphatase 1B inhibitors: comparison of the quality and predictivity among 3D QSAR models obtained from different conformer-based alignments. (17125198)
2006
33
Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. (15590660)
2005
34
Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins. (14753507)
2003
35
The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes. (12753400)
2003
36
An alternative signaling pathway based on nitryl chloride during intercellular induction of apoptosis. (11690564)
2001
37
Structure of tetragonal crystals of human erythrocyte catalase. (11134921)
2001
38
Adenocarcinoma in situ of the cervix-controversies in diagnosis and treatment. (17043583)
2001
39
Cilioretinal artery occlusion in posterior scleritis. (10872939)
2000
40
The role of cyclooxygenases in inflammation, cancer, and development. (10630643)
1999
41
Human colonic epithelial cells express galanin-1 receptors, which when activated cause Cl- secretion. (9886980)
1999
42
Up-regulation of p27Kip1, p21WAF1/Cip1 and p16Ink4a is associated with, but not sufficient for, induction of squamous differentiation. (9547295)
1998
43
Infundibulocystic basal cell carcinoma. (9649699)
1998
44
Several synthetic chemicals inhibit progesterone receptor-mediated transactivation in yeast. (9144411)
1997
45
Use of a urine enzyme immunoassay as a diagnostic tool for Chlamydia trachomatis urethritis in men. (1774248)
1991
46
Mononeuropathy multiplex (AAEE case report #11). (16758572)
1985
47
Ophthalmia neonatorum: relative efficacy of current prophylactic practices and treatment. (6386786)
1984
48
Gonorrhoea presenting as "sterile" pyuria. (7427537)
1980
49
Effect of hyperphenylalaninemia on fatty acid composition of lipids of rat brain myelin. (4357501)
1973
50

Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL6, TNF
29.6NFKB1, TNF
39.6NFKB1, TNF
49.2IL6, NFKB1, TNF
5
Show member pathways
9.2IL6, NFKB1, TNF
6
Show member pathways
9.2IL6, NFKB1, TNF
7
Show member pathways
9.2IL6, NFKB1, TNF
89.2IL6, NFKB1, TNF
99.2IL6, NFKB1, TNF
10
Show member pathways
9.2IL6, TLR8, TLR9
119.2CASP3, IL6, TNF
129.2IL6, TLR9, TNF
139.2IL6, TLR9, TNF
149.2IL6, TLR9, TNF
15
Show member pathways
9.2NFKB1, TLR8, TLR9
16
Show member pathways
9.1CASP3, NFKB1, TNF
17
Show member pathways
9.1CASP3, NFKB1, TNF
189.1CASP3, NFKB1, TNF
199.1CASP3, IL6, NFKB1
209.1CASP3, IL6, NFKB1
21
Show member pathways
9.1IL6, MX1, TNF
228.9IL6, TNF, VEGFA
23
Show member pathways
8.8IL6, TLR8, TLR9, TNF
248.7CASP3, IL6, NFKB1, TNF
25
Show member pathways
8.7CASP3, IL6, NFKB1, TNF
268.7CASP3, IL6, NFKB1, TNF
278.7CASP3, IL6, NFKB1, TNF
28
Show member pathways
8.7CASP3, IL6, NFKB1, TNF
29
Show member pathways
8.7CASP3, IL6, NFKB1, TNF
308.7CASP3, IL6, NFKB1, TNF
318.7IL6, NFKB1, TLR9, TNF
328.7CASP3, NFKB1, VEGFA
338.5F3, IL6, NFKB1, VEGFA
34
Show member pathways
8.4IL6, NFKB1, TLR8, TLR9, TNF
35
Show member pathways
8.4IL6, NFKB1, TLR8, TLR9, TNF
368.3CASP3, IL6, TNF, VEGFA
378.3CASP3, NFKB1, TNF, VEGFA
388.3CASP3, IL6, NFKB1, VEGFA
39
Show member pathways
8.3CASP3, IL6, NFKB1, VEGFA
40
Show member pathways
8.3CASP3, NFKB1, TLR8, TLR9, TNF
418.2CASP3, IL6, NFKB1, TLR9, TNF
42
Show member pathways
8.0F3, IL6, NFKB1, TLR8, TLR9, TNF
43
Show member pathways
7.8CASP3, IL6, NFKB1, TLR8, TLR9, TNF
44
Show member pathways
7.8CASP3, IL6, NFKB1, TLR8, TLR9, TNF
457.6CASP3, F3, IL6, NFKB1, TNF, VEGFA
467.6CASP3, F3, IL6, NFKB1, TNF, VEGFA
47
Show member pathways
7.6CASP3, IL6, MX1, NFKB1, TLR9, TNF
48
Show member pathways
7.2CASP3, IL6, MX1, NFKB1, TLR8, TLR9
497.0CASP3, IL6, NFKB1, TLR8, TLR9, TNF
50
Show member pathways
6.7CASP3, F3, IL6, NFKB1, TLR8, TLR9

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-8 biosynthetic processGO:004541610.4TLR8, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4IL6, TNF
3positive regulation of nitric oxide biosynthetic processGO:004542910.3IL6, TNF
4cellular response to nicotineGO:007131610.3NFKB1, TNF
5regulation of cytokine secretionGO:005070710.3TLR8, TLR9
6negative regulation of lipid storageGO:001088810.2IL6, TNF
7positive regulation of NF-kappaB import into nucleusGO:004234610.2TLR9, TNF
8negative regulation of fat cell differentiationGO:004559910.2IL6, TNF
9response to antibioticGO:004667710.2CASP3, IL6
10negative regulation of interleukin-6 productionGO:003271510.1TLR9, TNF
11response to amino acidGO:004320010.0CASP3, IL6
12positive regulation of interleukin-6 productionGO:003275510.0IL6, TNF
13response to bacteriumGO:000961710.0IL6, NFKB1
14positive regulation of protein complex assemblyGO:003133410.0TNF, VEGFA
15defense response to Gram-negative bacteriumGO:00508299.9IL6, TLR9
16positive regulation of cell adhesionGO:00457859.7TNF, VEGFA
17response to glucocorticoidGO:00513849.7CASP3, IL6, TNF
18response to woundingGO:00096119.7CASP3, F3, IL6
19I-kappaB kinase/NF-kappaB signalingGO:00072499.7NFKB1, TLR8, TNF
20response to virusGO:00096159.6MX1, TLR8, TNF
21positive regulation of JUN kinase activityGO:00435079.6TLR9, TNF
22toll-like receptor signaling pathwayGO:00022249.5NFKB1, TLR8, TLR9
23MyD88-dependent toll-like receptor signaling pathwayGO:00027559.5NFKB1, TLR8, TLR9
24cellular response to lipopolysaccharideGO:00712229.5IL6, NFKB1, TNF
25activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.4CASP3, F3, TNF
26positive regulation of peptidyl-serine phosphorylationGO:00331389.3IL6, TNF, VEGFA
27inflammatory responseGO:00069549.1IL6, NFKB1, TLR8, TNF
28response to lipopolysaccharideGO:00324969.1CASP3, F3, IL6
29positive regulation of NF-kappaB transcription factor activityGO:00510929.0IL6, NFKB1, TLR9, TNF
30defense response to virusGO:00516078.8IL6, MX1, TLR8
31positive regulation of gene expressionGO:00106288.7IL6, TLR9, VEGFA
32negative regulation of apoptotic processGO:00430668.5CASP3, IL6, NFKB1, VEGFA

Sources for Crimean-Congo Hemorrhagic Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet