CCHF
MCID: CRM001
MIFTS: 54

Crimean-Congo Hemorrhagic Fever (CCHF) malady

Infectious diseases, Rare diseases categories
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Summaries for Crimean-Congo Hemorrhagic Fever

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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, has material basis in crimean-congo hemorrhagic fever virus, which is transmitted by hyalomma ticks. the infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary: Crimean-Congo Hemorrhagic Fever, also known as crimean hemorrhagic fever, is related to thrombocytopenia and malaria, and has symptoms including fever/chilling, asthenia/fatigue/weakness and chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis. An important gene associated with Crimean-Congo Hemorrhagic Fever is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are TRAF Pathway and Toll Like Receptor 7/8 (TLR7/8) Cascade. The compounds fibrinogen and neopterin have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related mouse phenotype immune system.

CDC:3 Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was first characterized in the Crimea in 1944 and given the name Crimean hemorrhagic fever. It was then later recognized in 1969 as the cause of illness in the Congo, thus resulting in the current name of the disease.

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Crimean-Congo Hemorrhagic Fever, Aliases & Descriptions:

Name: Crimean-Congo Hemorrhagic Fever 8 10 48
Crimean Hemorrhagic Fever 8 48
Congo Hemorrhagic Fever 48 62
Congo-Crimean Haemorrhagic Fever 62
Crimean-Congo Haemorrhagic Fever 62
Congo-Crimean Hemorrhagic Fever 8
 
Hemorrhagic Fever Crimean-Congo 44
Hemorrhagic Fever, Crimean 62
Chf Congo Virus 8
Congo Fever 48
Cchf 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

48
crimean-congo hemorrhagic fever:
Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:12287
NCIt39 C34682
MeSH34 D006479
SNOMED-CT57 43489008
ICD9CM27 065.0
ICD10 via Orphanet26 A98.0
ICD1025 A98.0

Related Diseases for Crimean-Congo Hemorrhagic Fever

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Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to crimean-congo hemorrhagic fever

Symptoms for Crimean-Congo Hemorrhagic Fever

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Symptoms:

48 (show all 24)
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • cutaneous rash
  • purpura/petichiae
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • liver/hepatic steatosis
  • abnormal hepatic enzymes/transaminases
  • cough
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hepatitis/icterus/cholestasis
  • thoracic/chest pain
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • epistaxis/nose bleeding
  • gingivorrhagia/gingival bleeding
  • early death/lethality

HPO human phenotypes related to Crimean-Congo Hemorrhagic Fever:

(show all 20)
id Description Frequency HPO Source Accession
1 abnormality of temperature regulation hallmark (90%) HP:0004370
2 skin rash typical (50%) HP:0000988
3 hepatic steatosis typical (50%) HP:0001397
4 subcutaneous hemorrhage typical (50%) HP:0001933
5 diarrhea typical (50%) HP:0002014
6 nausea and vomiting typical (50%) HP:0002017
7 abdominal pain typical (50%) HP:0002027
8 migraine typical (50%) HP:0002076
9 elevated hepatic transaminases typical (50%) HP:0002910
10 myalgia typical (50%) HP:0003326
11 inflammatory abnormality of the eye typical (50%) HP:0100533
12 recurrent pharyngitis typical (50%) HP:0100776
13 gingival bleeding occasional (7.5%) HP:0000225
14 epistaxis occasional (7.5%) HP:0000421
15 sudden cardiac death occasional (7.5%) HP:0001645
16 thrombocytopenia occasional (7.5%) HP:0001873
17 leukopenia occasional (7.5%) HP:0001882
18 abnormality of coagulation occasional (7.5%) HP:0001928
19 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
20 chest pain occasional (7.5%) HP:0100749

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

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Drug clinical trials:

Search ClinicalTrials for Crimean-Congo Hemorrhagic Fever

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Genetic Tests for Crimean-Congo Hemorrhagic Fever

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Anatomical Context for Crimean-Congo Hemorrhagic Fever

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MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

32
Eye, Liver, Testes, Heart, Endothelial

Animal Models for Crimean-Congo Hemorrhagic Fever or affiliated genes

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MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2F3, CHIT1, TLR9, TLR8

Publications for Crimean-Congo Hemorrhagic Fever

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Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
Cytokine concentrations in pediatric patients with crimean-congo hemorrhagic Fever. (25361408)
2014
2
A novel AP92-like Crimean-Congo hemorrhagic fever virus strain, Greece. (24953797)
2014
3
Prevalence of crimean-congo hemorrhagic Fever virus in healthy population, livestock and ticks in kosovo. (25393542)
2014
4
Serosurvey of Crimean-Congo hemorrhagic fever virus in domestic animals, Gujarat, India, 2013. (25229708)
2014
5
Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011. (23195573)
2013
6
Evaluation of Crimean-Congo hemorrhagic fever virus infection in children. (24107215)
2013
7
Infection and propagation of Crimean-Congo hemorrhagic fever virus in embryonated chicken eggs. (23352881)
2013
8
Epidemiologic features and risk factors of Crimean-Congo hemorrhagic fever in Samsun province, Turkey. (23208513)
2013
9
Evaluation of renal involvement in children with Crimean-Congo hemorrhagic fever. (24270136)
2013
10
Influence of laboratory animal hosts on the life cycle of Hyalomma marginatum and implications for an in vivo transmission model for Crimean-Congo hemorrhagic fever virus. (23971007)
2013
11
Temporal modeling of Crimean-Congo hemorrhagic fever in eastern Iran. (23474177)
2013
12
Bayesian phylogeography of crimean-congo hemorrhagic Fever virus in europe. (24223988)
2013
13
Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)
2013
14
Comparative study between Ribavirin and Ribavirin plus Intravenous Immunoglobulin against Crimean Congo hemorrhagic fever. (24250699)
2013
15
The role of heparan sulphate in pathogenesis of Crimean-Congo hemorrhagic fever disease. (23995315)
2013
16
Factors associated with IgG positivity to Crimean-Congo hemorrhagic fever virus in the area with the highest seroprevalence in Greece. (23831367)
2013
17
Guineafowl, ticks and Crimean-Congo hemorrhagic fever in Turkey: the perfect storm? (23206535)
2013
18
Hepatocyte pathway alterations in response to in vitro Crimean Congo hemorrhagic fever virus infection. (24184319)
2013
19
Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya. (22925021)
2012
20
Crimean-Congo hemorrhagic fever virus in various ixodid tick species from a highly endemic area. (22119389)
2012
21
C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever. (22695238)
2012
22
Relationship between Crimean-Congo hemorrhagic fever virus strains circulating in Iran and Turkey: possibilities for transborder transmission. (22925023)
2012
23
Bradycardia in a patient with Crimean-Congo hemorrhagic fever related to ribavirin treatment. (23135017)
2012
24
Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey. (22192531)
2012
25
Effect of oral ribavirin treatment on the viral load and disease progression in Crimean-Congo hemorrhagic fever. (21106428)
2011
26
Co-infection of Malaria and Crimean-Congo Hemorrhagic Fever. (22347306)
2011
27
Crimean-Congo hemorrhagic fever, Afghanistan, 2009. (22000377)
2011
28
Crimean-Congo hemorrhagic fever serosurvey in at-risk professionals, Madagascar, 2008 and 2009. (21889395)
2011
29
Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. (20005156)
2010
30
Crimean-Congo hemorrhagic fever in Iran and neighboring countries. (20006541)
2010
31
Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran. (20854025)
2010
32
Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: a case-control study. (19168952)
2009
33
Ribavirin treatment for Crimean-Congo hemorrhagic fever. (20058332)
2009
34
A case of Crimean-congo hemorrhagic fever with pleural effusion. (19168966)
2009
35
A case of nosocomial transmission of Crimean-Congo hemorrhagic fever from patient to patient. (18948048)
2009
36
Modeling the spatial distribution of crimean-congo hemorrhagic fever outbreaks in Turkey. (18047397)
2007
37
Identification of a novel C-terminal cleavage of Crimean-Congo hemorrhagic fever virus PreGN that leads to generation of an NSM protein. (17409136)
2007
38
Cytokine levels in Crimean-Congo hemorrhagic fever. (16765637)
2006
39
A variable region in the Crimean-Congo hemorrhagic fever virus L segment distinguishes between strains isolated from different geographic regions. (16372290)
2006
40
Crimean-Congo hemorrhagic fever in Southeast of Iran. (16182370)
2006
41
Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein. (16352575)
2006
42
Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment. (15033561)
2004
43
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. (12885882)
2003
44
Treatment and prophylaxis with ribavirin for Crimean-Congo Hemorrhagic Fever--is it effective? (12666854)
2003
45
Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus. (11980926)
2002
46
Isolation of Crimean-Congo hemorrhagic fever virus from ticks on imported Sudanese sheep in Saudi Arabia. (17322717)
2000
47
Replication and tissue tropisms of Crimean-Congo hemorrhagic fever virus in experimentally infected adult Hyalomma truncatum (Acari: Ixodidae). (1404255)
1992
48
Distribution of Crimean-Congo hemorrhagic fever viral antibody in Senegal: environmental and vectorial correlates. (2122750)
1990
49
Comparison of methods for isolation and titration of Crimean-Congo hemorrhagic fever virus. (3095367)
1986
50
Results of a preliminary seroepidemiological survey for Crimean-Congo hemorrhagic fever virus in Egypt. (25013)
1978

Variations for Crimean-Congo Hemorrhagic Fever

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Expression for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Expression patterns in normal tissues for genes affiliated with Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1TLR8, TLR9
2
Show member pathways
9.1TLR9, TLR8
39.1TLR9, TLR8
4
Show member pathways
9.1TLR9, TLR8
5
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1TLR9, TLR8
69.1TLR9, TLR8
7
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1TLR8, TLR9
8
Show member pathways
IL27-mediated signaling events37
9.1TLR9, TLR8
99.1TLR9, TLR8
10
Show member pathways
9.1TLR8, TLR9
119.1TLR9, TLR8
12
Show member pathways
9.1TLR9, TLR8
13
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.6F3, TLR9, TLR8

Compounds for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Compounds related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1fibrinogen449.5F3, CHIT1
2neopterin449.5CHIT1, MX1
3imiquimod44 61 28 1112.4MX1, TLR8
4resiquimod44 6110.3TLR9, TLR8
5polysaccharide449.2F3, CHIT1
6endotoxin449.1F3, TLR9
7rantes448.9MX1, TLR9
8poly(i-c)448.7MX1, TLR9, TLR8

GO Terms for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057649.2CHIT1, TLR9
2endolysosome membraneGO:0360209.1TLR9, TLR8
3endosome membraneGO:0100088.8TLR9, TLR8
4endoplasmic reticulum membraneGO:0057898.4MX1, TLR9, TLR8

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-alpha biosynthetic processGO:0453569.3TLR9, TLR8
2positive regulation of interferon-beta biosynthetic processGO:0453599.3TLR9, TLR8
3positive regulation of interferon-gamma biosynthetic processGO:0450789.3TLR9, TLR8
4toll-like receptor 9 signaling pathwayGO:0341629.2TLR9, TLR8
5response to virusGO:0096159.2MX1, TLR8
6toll-like receptor signaling pathwayGO:0022249.1TLR9, TLR8
7inflammatory responseGO:0069549.1TLR9, TLR8
8defense response to virusGO:0516079.0MX1, TLR8
9innate immune responseGO:0450878.6TLR8, TLR9, MX1

Products for genes affiliated with Crimean-Congo Hemorrhagic Fever

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Sources for Crimean-Congo Hemorrhagic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet