CCHF
MCID: CRM001
MIFTS: 55

Crimean-Congo Hemorrhagic Fever (CCHF) malady

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Crimean-Congo Hemorrhagic Fever

Aliases & Descriptions for Crimean-Congo Hemorrhagic Fever:

Name: Crimean-Congo Hemorrhagic Fever 12 56 3 14
Hemorrhagic Fever, Crimean 42 69
Congo Hemorrhagic Fever 56 69
Cchf 56 3
Crimean Hemorrhagic Fever [chf Congo Virus] 12
Congo-Crimean Hemorrhagic Fever 12
Hemorrhagic Fever Crimean-Congo 52
Crimean Hemorrhagic Fever 56
Chf Congo Virus 12
Congo Fever 56

Characteristics:

Orphanet epidemiological data:

56
crimean-congo hemorrhagic fever
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12287
ICD10 33 A98.0
ICD9CM 35 065.0
MeSH 42 D006479
NCIt 47 C34682
SNOMED-CT 64 43489008
Orphanet 56 ORPHA99827
ICD10 via Orphanet 34 A98.0
UMLS 69 C0019099

Summaries for Crimean-Congo Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has symptom headache, has symptom high fever, has symptom back pain, has symptom joint pain, has symptom stomach pain, has symptom vomiting, has symptom red eyes, has symptom flushed face, has symptom red throat, has symptom petechiae (red spots) on the palate, has symptom jaundice, has symptom nosebleeds, and has symptom blood in the feces and urine.

MalaCards based summary : Crimean-Congo Hemorrhagic Fever, also known as hemorrhagic fever, crimean, is related to hemorrhagic fever and rift valley fever, and has symptoms including headache, high fever and back pain. An important gene associated with Crimean-Congo Hemorrhagic Fever is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and testes, and related phenotypes are hematopoietic system and cellular

CDC : 3 Crimean-Congo hemorrhagic fever is found in Eastern Europe, particularly in the former Soviet Union, throughout the Mediterranean, in northwestern China, central Asia, southern Europe, Africa, the Middle East, and the Indian subcontinent.

Related Diseases for Crimean-Congo Hemorrhagic Fever

Diseases related to Crimean-Congo Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 11.4
2 rift valley fever 10.4
3 endotheliitis 10.3
4 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
5 dyslexia 5 10.2 IL6 TNF
6 aortic atherosclerosis 10.2 IL6 TNF
7 unilateral multicystic dysplastic kidney 10.2 IL6 TNF
8 thymic neuroendocrine carcinoma 10.2 IL6 TNF
9 swine influenza 10.2 IL6 TNF
10 drug dependence 10.2 IL6 TNF
11 senile atrophy of choroid 10.2 CASP3 VEGFA
12 transient tic disorder 10.2 IL6 TNF
13 west nile virus 10.2
14 tick-borne encephalitis 10.2
15 encephalitis 10.2
16 anal paget's disease 10.2 IL6 TNF
17 papilledema 10.2 IL6 TNF
18 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 IL6 TNF
19 aortic coarctation 10.1 IL6 TNF
20 preaxial polydactyly of fingers 10.1 IL6 TNF
21 human immunodeficiency virus infectious disease 10.1 IL6 TNF
22 craniosynostosis, type 1 10.1 IL6 VEGFA
23 secretory diarrhea myopathy and deafness 10.1 F3 IL6
24 cardiac tuberculosis 10.1 IL6 VEGFA
25 esophagus lymphoma 10.1 IL6 TNF
26 immunoglobulin g deficiency 10.1 CASP3 IL6 TNF
27 splenic marginal zone lymphoma 10.1 CASP3 IL6 TNF
28 depressed scar 10.1 F3 IL6 TNF
29 meningitis 10.1 CASP3 IL6 TNF
30 membranoproliferative glomerulonephritis 10.1 F3 IL6 TNF
31 tinea capitis 10.1 IL6 TNF
32 uterine corpus cancer 10.1 CXCL10 F3 TNF
33 prinzmetal's variant angina 10.0 CASP3 IL6 VEGFA
34 tracheal calcification 10.0 GPT TNF
35 placenta praevia 10.0 CASP3 TNF VEGFA
36 degenerative disc disease 10.0 IL6 TNF VEGFA
37 vulvitis 10.0 F3 IL6 VEGFA
38 conjugate gaze palsy 10.0 IL6 VEGFA
39 bipolar i disorder 10.0 IL6 TNF VEGFA
40 leukoplakia of vagina 10.0 IL6 TNF VEGFA
41 ectodermal dysplasia bartalos type 10.0 IL6 TNF VEGFA
42 bladder signet ring cell adenocarcinoma 10.0 CXCL10 IL6 TNF
43 choanal atresia, bilateral 10.0 CXCL10 IL6 TNF
44 ischemia 10.0
45 malaria 10.0
46 purpura 10.0
47 pancreatitis 10.0
48 pulmonary hypertension 10.0
49 myocarditis 10.0
50 hemophagocytic lymphohistiocytosis 10.0

Graphical network of the top 20 diseases related to Crimean-Congo Hemorrhagic Fever:



Diseases related to Crimean-Congo Hemorrhagic Fever

Symptoms & Phenotypes for Crimean-Congo Hemorrhagic Fever

Symptoms:

12 (show all 13)
  • headache
  • high fever
  • back pain
  • joint pain
  • stomach pain
  • vomiting
  • red eyes
  • flushed face
  • red throat
  • petechiae (red spots) on the palate
  • jaundice
  • nosebleeds
  • blood in the feces

Human phenotypes related to Crimean-Congo Hemorrhagic Fever:

56 32 (show all 23)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 56 32 Very frequent (99-80%) HP:0012378
2 myalgia 56 32 Frequent (79-30%) HP:0003326
3 fever 56 32 Very frequent (99-80%) HP:0001945
4 headache 56 32 Frequent (79-30%) HP:0002315
5 chest pain 56 32 Occasional (29-5%) HP:0100749
6 abdominal pain 56 32 Frequent (79-30%) HP:0002027
7 diarrhea 56 32 Frequent (79-30%) HP:0002014
8 nausea and vomiting 56 32 Frequent (79-30%) HP:0002017
9 recurrent pharyngitis 56 32 Frequent (79-30%) HP:0100776
10 hepatic steatosis 56 32 Frequent (79-30%) HP:0001397
11 elevated hepatic transaminases 56 32 Frequent (79-30%) HP:0002910
12 thrombocytopenia 56 32 Occasional (29-5%) HP:0001873
13 jaundice 56 32 Occasional (29-5%) HP:0000952
14 gastrointestinal hemorrhage 56 32 Occasional (29-5%) HP:0002239
15 epistaxis 56 32 Occasional (29-5%) HP:0000421
16 skin rash 56 32 Frequent (79-30%) HP:0000988
17 cough 56 32 Frequent (79-30%) HP:0012735
18 gingival bleeding 56 32 Occasional (29-5%) HP:0000225
19 petechiae 56 32 Frequent (79-30%) HP:0000967
20 uveitis 56 32 Frequent (79-30%) HP:0000554
21 leukopenia 56 32 Occasional (29-5%) HP:0001882
22 cardiorespiratory arrest 56 32 Occasional (29-5%) HP:0006543
23 abnormal bleeding 56 Occasional (29-5%)

MGI Mouse Phenotypes related to Crimean-Congo Hemorrhagic Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 CASP3 CXCL10 F3 GPT IL6 NFKB1
2 cellular MP:0005384 10 CASP3 CXCL10 F3 IL6 NFKB1 TNF
3 homeostasis/metabolism MP:0005376 9.97 TNF VEGFA CASP3 CXCL10 F3 IL6
4 immune system MP:0005387 9.92 NFKB1 TLR8 TNF VEGFA CASP3 CXCL10
5 digestive/alimentary MP:0005381 9.83 CASP3 IL6 NFKB1 TNF VEGFA
6 integument MP:0010771 9.73 CASP3 F3 IL6 NFKB1 TNF VEGFA
7 muscle MP:0005369 9.63 CASP3 F3 IL6 NFKB1 TNF VEGFA
8 nervous system MP:0003631 9.5 CASP3 CXCL10 F3 IL6 NFKB1 TNF
9 respiratory system MP:0005388 9.1 CASP3 F3 IL6 NFKB1 TNF VEGFA

Drugs & Therapeutics for Crimean-Congo Hemorrhagic Fever

Drugs for Crimean-Congo Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2 Anti-Infective Agents Phase 2
3 Antimetabolites Phase 2
4 Antiviral Agents Phase 2
5
Formaldehyde Approved, Vet_approved Phase 1 50-00-0 712
6 Vaccines Phase 1
7 Pharmaceutical Solutions Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities Enrolling by invitation NCT00992693 Phase 2
2 Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans Active, not recruiting NCT03020771 Phase 1
3 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
4 Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever Enrolling by invitation NCT02483260

Search NIH Clinical Center for Crimean-Congo Hemorrhagic Fever

Cochrane evidence based reviews: hemorrhagic fever, crimean

Genetic Tests for Crimean-Congo Hemorrhagic Fever

Anatomical Context for Crimean-Congo Hemorrhagic Fever

MalaCards organs/tissues related to Crimean-Congo Hemorrhagic Fever:

39
Eye, Skin, Testes, Endothelial, Heart, Neutrophil

Publications for Crimean-Congo Hemorrhagic Fever

Articles related to Crimean-Congo Hemorrhagic Fever:

(show top 50) (show all 499)
id Title Authors Year
1
Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran. ( 27308275 )
2016
2
Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. ( 27353580 )
2016
3
Does Crimean-Congo Hemorrhagic Fever Cause a Vasculitic Reaction with Pulmonary Artery Enlargement and Acute Pulmonary Hypertension? ( 27344326 )
2016
4
The prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever. ( 27089100 )
2016
5
Multi-center prospective evaluation of discharge criteria for hospitalized patients with Crimean-Congo Hemorrhagic Fever. ( 27424492 )
2016
6
Crimean-Congo Hemorrhagic Fever Knowledge, Attitudes, Practices, Risk Factors, and Seroprevalence in Rural Georgian Villages with Known Transmission in 2014. ( 27336731 )
2016
7
Crimean-Congo hemorrhagic fever among children in Iran. ( 27878461 )
2016
8
A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus. ( 27713073 )
2016
9
Relationship between IFNA1, IFNA5, IFNA10, and IFNA17 gene polymorphisms and Crimean-Congo hemorrhagic fever prognosis in a Turkish population range. ( 26694082 )
2016
10
Determination of nasal mucociliary clearance time and nasal symptom in patients with crimean-congo hemorrhagic fever. ( 27813123 )
2016
11
Crimean-Congo Hemorrhagic Fever in Dubai, United Arab Emirates, 2010: Case Report. ( 27795839 )
2016
12
Phylogeography of Crimean Congo Hemorrhagic Fever Virus. ( 27880794 )
2016
13
Biosafety standards for working with Crimean-Congo hemorrhagic fever virus. ( 27667586 )
2016
14
PRESEPSIN LEVELS OF PATIENTS WITH CRIMEAN-CONGO HEMORRHAGIC FEVER. ( 27000451 )
2016
15
Examination of the specific clinical symptoms and laboratory findings of Crimean-Congo hemorrhagic fever. ( 27353587 )
2016
16
Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses. ( 27217069 )
2016
17
Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus. ( 27110812 )
2016
18
A competitive ELISA for species-independent detection of Crimean-Congo hemorrhagic fever virus specific antibodies. ( 27623345 )
2016
19
Crimean-Congo Hemorrhagic Fever with Acute Subdural Hematoma, Mauritania, 2012. ( 27315138 )
2016
20
The prognostic significance of serum TGF-I^1 levels in patients with Crimean-Congo hemorrhagic fever. ( 27467498 )
2016
21
A retrospective controlled study of thiol disulfide homeostasis as a novel marker in Crimean Congo hemorrhagic fever. ( 27159644 )
2016
22
Molecular analysis of Crimean-Congo hemorrhagic fever virus and Rickettsia in Hyalomma marginatum ticks removed from patients (Spain) and birds (Spain and Morocco), 2009-2015. ( 27215620 )
2016
23
Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana. ( 27392037 )
2016
24
Protective role of host aquaporin 6 against Hazara virus, a model for Crimean-Congo hemorrhagic fever virus infection. ( 26976854 )
2016
25
Phylogeny of tick-derived Crimean-Congo hemorrhagic fever virus strains in Iran. ( 27491289 )
2016
26
Possible sexual transmission of Crimean-Congo hemorrhagic fever. ( 26972040 )
2016
27
Molecular Assay on Crimean Congo Hemorrhagic Fever Virus in Ticks (Ixodidae) Collected from Kermanshah Province, Western Iran. ( 27308296 )
2016
28
Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity. ( 27775001 )
2016
29
Seroprevalence of Crimean-Congo hemorrhagic fever in Turkey's Van Province. ( 27169950 )
2016
30
MicroRNA expression profiles in patients with acute Crimean Congo Hemorrhagic Fever reveal possible adjustments to cellular pathways. ( 27551771 )
2016
31
A child with an unusual complication of Crimean-Congo hemorrhagic fever: Hemorrhagic pleural effusion. ( 27004585 )
2016
32
Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. ( 27666016 )
2016
33
Thorax CT findings in patients with Crimean-Congo hemorrhagic fever (CCHF). ( 27818861 )
2016
34
Crimean-Congo hemorrhagic fever virus lineages Europe 1 and Europe 2 in Bulgarian ticks. ( 27378409 )
2016
35
Novel, In-House, SYBR Green Based One-Step rRT-PCR: Rapid and Accurate Diagnosis of Crimean-Congo Hemorrhagic Fever Virus in Suspected Patients From Iran. ( 27099688 )
2016
36
Clinical severity in forecasting platelet to lymphocyte ratio in Crimean-Congo hemorrhagic fever patients. ( 27501696 )
2016
37
Epidemiological Survey of Crimean-Congo Hemorrhagic Fever (CCHF), a Fatal Infectious Disease in Khuzestan Province, Southwest Iran, During 1999 - 2015. ( 27540454 )
2016
38
Heat Shock Protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle. ( 27512070 )
2016
39
Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever. ( 27378224 )
2016
40
Serum sTREM-1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection. ( 26877157 )
2016
41
Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system. ( 26935918 )
2016
42
The first fatal case of Crimean-Congo Hemorrhagic Fever due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus. ( 26902209 )
2016
43
Molecular epidemiology of Crimean-Congo hemorrhagic fever virus detected from ticks of one humped camels (Camelus dromedarius) population in northeastern Iran. ( 27065608 )
2016
44
Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area. ( 27677379 )
2016
45
Crimean-Congo Hemorrhagic Fever Virus in Bulgaria and Turkey. ( 27467142 )
2016
46
Crimean-Congo hemorrhagic fever - A ticking bomb? ( 27044612 )
2016
47
Crimean-Congo hemorrhagic fever with hyperbilirubinemia and ascites: An unusual presentation. ( 26129885 )
2016
48
Sero-epidemiological survey of Crimean-Congo hemorrhagic fever virus in Tunisia. ( 26956221 )
2016
49
Crimean Congo Hemorrhagic Fever Virus and Alkhurma (Alkhumra) Virus in Ticks in Djibouti. ( 27508862 )
2016
50
Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran. ( 27047968 )
2016

Variations for Crimean-Congo Hemorrhagic Fever

Expression for Crimean-Congo Hemorrhagic Fever

Search GEO for disease gene expression data for Crimean-Congo Hemorrhagic Fever.

Pathways for Crimean-Congo Hemorrhagic Fever

Pathways related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 CASP3 CXCL10 IL6 NFKB1 TNF VEGFA
2
Show member pathways
13.26 CASP3 CXCL10 IL6 NFKB1 TLR8 TNF
3
Show member pathways
13.2 CASP3 CXCL10 IL6 NFKB1 TNF VEGFA
4
Show member pathways
13.16 CASP3 CXCL10 IL6 NFKB1 TNF
5
Show member pathways
12.86 F3 IL6 NFKB1 TLR8 TNF
6
Show member pathways
12.77 CASP3 IL6 NFKB1 TNF
7
Show member pathways
12.75 CASP3 CXCL10 IL6 NFKB1 TLR8 TNF
8
Show member pathways
12.73 CASP3 IL6 TNF VEGFA
9
Show member pathways
12.67 CASP3 CXCL10 IL6 NFKB1 TNF
10
Show member pathways
12.62 CXCL10 IL6 NFKB1 TNF
11
Show member pathways
12.58 IL6 NFKB1 TLR8 TNF
12 12.56 CASP3 IL6 NFKB1 VEGFA
13
Show member pathways
12.49 CASP3 NFKB1 TLR8 TNF VEGFA
14 12.43 CXCL10 NFKB1 TLR8 TNF
15
Show member pathways
12.23 IL6 NFKB1 TNF
16 12.2 CASP3 TNF VEGFA
17
Show member pathways
12.19 CASP3 CXCL10 IL6 NFKB1 TNF
18
Show member pathways
12.17 IL6 NFKB1 TNF
19
Show member pathways
12.16 CASP3 NFKB1 VEGFA
20
Show member pathways
12.16 CASP3 NFKB1 TNF
21
Show member pathways
12.16 IL6 NFKB1 TLR8 TNF
22 12.12 CASP3 IL6 NFKB1 TNF
23 12.05 CASP3 NFKB1 VEGFA
24
Show member pathways
12.03 CASP3 NFKB1 TNF
25 12 NFKB1 TNF VEGFA
26
Show member pathways
11.94 CASP3 NFKB1 TNF
27
Show member pathways
11.94 CXCL10 IL6 NFKB1 TLR8 TNF
28 11.9 CASP3 CXCL10 IL6 TNF
29 11.89 IL6 TNF VEGFA
30
Show member pathways
11.87 IL6 NFKB1 TNF
31 11.87 CASP3 IL6 NFKB1 TNF VEGFA
32
Show member pathways
11.86 IL6 TLR8 TNF
33 11.82 IL6 NFKB1 VEGFA
34 11.79 CASP3 IL6 NFKB1 TNF
35 11.77 IL6 TNF VEGFA
36 11.66 CASP3 IL6 NFKB1 TNF
37 11.65 CASP3 IL6 NFKB1 TLR8 TNF VEGFA
38 11.64 IL6 NFKB1 TNF
39 11.6 CASP3 IL6 NFKB1
40 11.59 CASP3 CXCL10 IL6 NFKB1 TNF
41
Show member pathways
11.53 IL6 NFKB1 TNF VEGFA
42 11.47 CXCL10 IL6 TNF
43 11.46 IL6 NFKB1 TNF
44 11.45 NFKB1 TNF VEGFA
45 11.45 CASP3 IL6 NFKB1 TNF
46 11.38 CASP3 IL6 NFKB1 VEGFA
47 11.27 IL6 TNF
48 11.27 IL6 NFKB1 TNF
49 11.24 IL6 NFKB1
50 11.23 CASP3 TNF

GO Terms for Crimean-Congo Hemorrhagic Fever

Cellular components related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 CXCL10 F3 IL6 NFKB1 TNF VEGFA
2 extracellular space GO:0005615 9.43 CXCL10 F3 GPT IL6 TNF VEGFA
3 external side of plasma membrane GO:0009897 8.92 CXCL10 IL6 TLR8 TNF

Biological processes related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.96 CXCL10 IL6 NFKB1 TNF VEGFA
2 negative regulation of apoptotic process GO:0043066 9.88 CASP3 IL6 NFKB1 VEGFA
3 regulation of cell proliferation GO:0042127 9.8 CXCL10 IL6 TNF
4 response to lipopolysaccharide GO:0032496 9.79 CASP3 CXCL10 IL6
5 positive regulation of cell migration GO:0030335 9.77 CXCL10 F3 VEGFA
6 defense response to virus GO:0051607 9.77 CXCL10 IL6 TLR8
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 IL6 NFKB1 TNF
8 response to virus GO:0009615 9.7 CXCL10 TLR8 TNF
9 response to antibiotic GO:0046677 9.62 CASP3 IL6
10 positive regulation of protein complex assembly GO:0031334 9.61 TNF VEGFA
11 positive regulation of protein kinase B signaling GO:0051897 9.61 F3 IL6 TNF
12 negative regulation of myoblast differentiation GO:0045662 9.58 CXCL10 TNF
13 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.58 CASP3 F3 TNF
14 positive regulation of chemokine production GO:0032722 9.57 IL6 TNF
15 positive regulation of positive chemotaxis GO:0050927 9.54 F3 VEGFA
16 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.54 IL6 TNF VEGFA
17 response to auditory stimulus GO:0010996 9.51 CXCL10 IL6
18 response to glucocorticoid GO:0051384 9.5 CASP3 IL6 TNF
19 negative regulation of lipid storage GO:0010888 9.49 IL6 TNF
20 cellular response to nicotine GO:0071316 9.48 NFKB1 TNF
21 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.46 TLR8 TNF
22 inflammatory response GO:0006954 9.35 CXCL10 IL6 NFKB1 TLR8 TNF
23 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.33 NFKB1 TLR8 TNF
24 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.26 IL6 TNF
25 cellular response to lipopolysaccharide GO:0071222 8.92 CXCL10 IL6 NFKB1 TNF

Molecular functions related to Crimean-Congo Hemorrhagic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 CASP3 F3 TNF
2 cytokine activity GO:0005125 8.92 CXCL10 IL6 TNF VEGFA

Sources for Crimean-Congo Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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