CCHD
MCID: CRT057
MIFTS: 20

Critical Congenital Heart Disease (CCHD) malady

Aliases & Classifications for Critical Congenital Heart Disease

Aliases & Descriptions for Critical Congenital Heart Disease:

Name: Critical Congenital Heart Disease 25
Critical Congenital Heart Defects 25
Cchd 25

Summaries for Critical Congenital Heart Disease

Genetics Home Reference : 25 Critical congenital heart disease (CCHD) is a term that refers to a group of serious heart defects that are present from birth. These abnormalities result from problems with the formation of one or more parts of the heart during the early stages of embryonic development. CCHD prevents the heart from pumping blood effectively or reduces the amount of oxygen in the blood. As a result, organs and tissues throughout the body do not receive enough oxygen, which can lead to organ damage and life-threatening complications. Individuals with CCHD usually require surgery soon after birth.

MalaCards based summary : Critical Congenital Heart Disease, also known as critical congenital heart defects, is related to heart disease and brain injury. The drugs Heparin and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain.

Related Diseases for Critical Congenital Heart Disease

Diseases related to Critical Congenital Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 heart disease 10.7
2 brain injury 9.8
3 birth defects 9.8

Symptoms & Phenotypes for Critical Congenital Heart Disease

Drugs & Therapeutics for Critical Congenital Heart Disease

Drugs for Critical Congenital Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
3
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
4
Iron Approved Phase 4,Phase 2 7439-89-6 23925
5
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7 calcium heparin Phase 4
8 Hemostatics Phase 4
9 Fibrinolytic Agents Phase 4
10 Anticoagulants Phase 4,Phase 1
11 Calcium, Dietary Phase 4
12 Estradiol valerate Phase 4 979-32-8
13 Contraceptive Agents Phase 4
14 Trace Elements Phase 4
15 Hormone Antagonists Phase 4,Phase 2,Phase 1
16 Anesthetics Phase 4,Phase 3
17 Hormones Phase 4,Phase 2,Phase 1
18 Anesthetics, General Phase 4
19 Anesthetics, Inhalation Phase 4
20 Anesthetics, Intravenous Phase 4
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
22 Hypnotics and Sedatives Phase 4
23 Estradiol 17 beta-cypionate Phase 4
24 Estradiol 3-benzoate Phase 4
25 Estrogens Phase 4
26 Polyestradiol phosphate Phase 4
27 Liver Extracts Phase 4
28 Micronutrients Phase 4
29 Central Nervous System Depressants Phase 4,Phase 3
30
Bosentan Approved, Investigational Phase 3,Phase 2 147536-97-8 104865
31 Endothelin Receptor Antagonists Phase 3,Phase 2
32 Antihypertensive Agents Phase 3,Phase 2
33
Hydrocortisone Approved, Vet_approved Phase 2,Phase 1 50-23-7 5754 657311
34
Macitentan Approved Phase 2 441798-33-0
35
Glycerol Approved, Experimental Phase 2 56-81-5 753
36
Hydroxychloroquine Approved Phase 2 118-42-3 3652
37
Butyric Acid Experimental Phase 2 107-92-6 264
38 Neurotransmitter Agents Phase 1, Phase 2
39 Cortisol succinate Phase 2,Phase 1
40 Peripheral Nervous System Agents Phase 1, Phase 2
41 Endothelin A Receptor Antagonists Phase 2
42 Hydrocortisone 17-butyrate 21-propionate Phase 2,Phase 1
43 Hydrocortisone acetate Phase 2,Phase 1
44 Hydrocortisone-17-butyrate Phase 2
45 Anti-Asthmatic Agents Phase 1, Phase 2
46 Immunoglobulins Phase 2
47 Anti-Inflammatory Agents Phase 2
48 Respiratory System Agents Phase 1, Phase 2
49 Antibodies Phase 2
50 Autonomic Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 61)
id Name Status NCT ID Phase
1 Platelet Function With New Pediatric Oxygenator and Heparin and Non Heparin Coating in Pediatric Cardiac Surgery Unknown status NCT01648712 Phase 4
2 Effects of Propofol and Isoflurane on Pulmonary Vascular Resistance Completed NCT01212523 Phase 4
3 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4
4 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
5 Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02222532 Phase 3
6 Safety and Efficacy Study of Ambrisentan in Subjects With Pulmonary Hypertension Completed NCT00380068 Phase 3
7 Right to Left Cardiac Shunt Detection Terminated NCT01773252 Phase 3
8 Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH) Terminated NCT00313196 Phase 3
9 Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH) Terminated NCT00310830 Phase 3
10 Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease Completed NCT00590018 Phase 2
11 Citrulline for Children Undergoing Cardiopulmonary Bypass Surgery Completed NCT00201214 Phase 1, Phase 2
12 Mixed Venous Oxygen Saturation From Central Venous Line, Venous Side of Heart Lung Machine and the Pulmonary Artery Completed NCT02498626 Phase 2
13 Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Completed NCT02021292 Phase 2
14 Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology. Completed NCT01292551 Phase 2
15 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2
16 Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery Recruiting NCT02046135 Phase 2
17 Preventive Approach to Congenital Heart Block With Hydroxychloroquine Recruiting NCT01379573 Phase 2
18 Impact of Early Enteral Feeding on Splanchnic Blood Flow After Surgery for Critical Heart Disease in the Newborn Terminated NCT00919945 Phase 2
19 Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease Terminated NCT00492531 Phase 2
20 Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients Withdrawn NCT00981591 Phase 1, Phase 2
21 Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery Completed NCT01839812 Phase 1
22 Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support Recruiting NCT02631174 Phase 1
23 Prospective Analysis of Cerebral Perfusion Using Head Ultrasound and Multi-source-detector Near Infrared Spectroscopy (NIRS) Imaging Unknown status NCT01082536
24 Trends In Oxygen Saturation In Healthy Term Infants In The First Few Days Of Life: The "TOST" Study Unknown status NCT02095041
25 The Impact of Implementing a Universal Newborn Screening for Critical Congenital Heart Disease Completed NCT01749059
26 Newborn Screening for Critical Congenital Heart Disease Completed NCT01765205 Early Phase 1
27 Leuven Growing Into Deficit Follow-up Study Completed NCT01632813
28 Micronutrients in Children in Critical Care With Cardiac Conditions Completed NCT02409706
29 Biventricular Pacing in Children After Surgery for Congenital Heart Disease Completed NCT02806245
30 Hypoxemia in Infants After Palliative Surgery Completed NCT00327977
31 A Critical Appraisal of the Role of Near Infrared Spectroscopy (NIRS) in the Pediatric Intensive Care Unit (PICU) Completed NCT01282099
32 Hybrid Closure of Congenital Heart Disease Completed NCT02794584
33 Post-bypass Prophylactic IVIG in Infants and Neonates Completed NCT02043379
34 An Intervention to Reduce Delirium After Cardiac Surgery Completed NCT02587039
35 Effect of Postop Steroids on Cardiovascular/Respiratory Function in Neonates Undergoing Cardiopulmonary Bypass Completed NCT01595386
36 Optimizing Health Among Children With Congenital Heart Defects Completed NCT00974688
37 Lactate Levels During Cardiopulmonary Bypass in Pediatric Patients Completed NCT02618707
38 Families and Pediatric Cardiac Surgery Multidisciplinary Teams: How Well Do We Communicate Completed NCT01371864
39 The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary Hypertension Completed NCT01313832
40 Pulse Oximeter Screening in Congenital Heart Disease Recruiting NCT02731248
41 Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study Recruiting NCT03023644
42 Genetic Determinants of Congenital Heart Disease Outcomes Recruiting NCT01656941
43 Biventricular Pacing in Children With Congenital Heart Disease Recruiting NCT02644824
44 Improving Neurodevelopment in Adolescents With Congenital Heart Disease Recruiting NCT02759263
45 Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study) Recruiting NCT02184169
46 Right Lateral Positioning of Postoperative Pediatric Cardiac Surgery Recruiting NCT02622152
47 Impact of Pre-operative Steroids on Adrenal Insufficiency Recruiting NCT02956707
48 Stress Echo 2020 - The International Stress Echo Study Recruiting NCT03049995
49 Open Lung Strategy in Critically Ill Morbid Obese Patients Recruiting NCT02503241
50 Characterization of Pulmonary Artery Stenoses in Alagille Syndrome - a Medical Record Review Recruiting NCT01515631

Search NIH Clinical Center for Critical Congenital Heart Disease

Genetic Tests for Critical Congenital Heart Disease

Anatomical Context for Critical Congenital Heart Disease

MalaCards organs/tissues related to Critical Congenital Heart Disease:

39
Heart, Testes, Brain

Publications for Critical Congenital Heart Disease

Articles related to Critical Congenital Heart Disease:

(show top 50) (show all 123)
id Title Authors Year
1
Should New Zealand introduce nationwide pulse oximetry screening for the detection of critical congenital heart disease in newborn infants? ( 28081558 )
2017
2
A Post-operative Feeding Protocol to Improve Outcomes for Neonates With Critical Congenital Heart Disease. ( 28063770 )
2017
3
Critical Congenital Heart Disease Newborn Screening Implementation: Lessons Learned. ( 28092064 )
2017
4
Critical congenital heart disease screening. ( 27390667 )
2016
5
Pulse Oximetry Screening for Critical Congenital Heart Disease after Home Birth and Early Discharge. ( 26746119 )
2016
6
A novel, more efficient, staged approach for critical congenital heart disease screening. ( 27831548 )
2016
7
Development of a Newborn Screening Program for Critical Congenital Heart Disease (CCHD) in Taipei. ( 27073996 )
2016
8
Pediatric Resident Attitudes and Knowledge of Critical Congenital Heart Disease Screening. ( 27160097 )
2016
9
Association of Prenatal Diagnosis of Critical Congenital Heart Disease With Postnatal Brain Development and the Risk of Brain Injury. ( 26902528 )
2016
10
Legal and Ethical Considerations in Allowing Parental Exemptions From Newborn Critical Congenital Heart Disease (CCHD) Screening. ( 26734736 )
2016
11
Screening for Critical Congenital Heart Disease. ( 26876122 )
2016
12
Giant dissecting ventricular septal haematoma associated with critical congenital heart disease. ( 27365006 )
2016
13
Antenatal diagnosis of critical congenital heart disease. Optimal place of delivery is where appropriate care can be delivered. ( 26819268 )
2016
14
Parents Do Not Always Have to Get Their Way: Why Critical Congenital Heart Disease Screening for Newborns Should Be Mandatory. ( 26734746 )
2016
15
Universal Pulse Oximetry Screening for Early Detection of Critical Congenital Heart Disease. ( 27279759 )
2016
16
Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Position Statement on Pulse Oximetry Screening in Newborns to Enhance Detection of Critical Congenital Heart Disease. ( 28043739 )
2016
17
Newborn Critical Congenital Heart Disease Screening Using Pulse Oximetry: Nursing Aspects. ( 27603538 )
2016
18
Pulse Oximetry Overestimates Oxyhemoglobin in Neonates with Critical Congenital Heart Disease. ( 26800085 )
2016
19
Pulse oximetry screening for critical congenital heart disease in planned out of hospital births and the incidence of critical congenital heart disease in the Plain community. ( 27583398 )
2016
20
Complications of Long-Term Prostaglandin E1 Use in Newborns With Ductal-Dependent Critical Congenital Heart Disease. ( 26813395 )
2016
21
Letting Parents Say "No:" A Small Price to Pay for State-Mandated Critical Congenital Heart Disease (CCHD) Screening. ( 26734737 )
2016
22
Pulse oximetry screening: a review of diagnosing critical congenital heart disease in newborns. ( 27468253 )
2016
23
Is Pulse Oximetry Useful for Screening Neonates for Critical Congenital Heart Disease at High Altitudes? ( 27090652 )
2016
24
Pulse oximetry could significantly enhance the early detection of critical congenital heart disease in neonatal intensive care units. ( 27540721 )
2016
25
Prenatal Diagnosis of Critical Congenital Heart Disease Reduces Risk of Death from Cardiovascular Compromise Prior to Planned Cardiac Surgery: A Meta-analysis. ( 25904437 )
2015
26
Long-Term Prostaglandin E1 Infusion for Newborns with Critical Congenital Heart Disease. ( 26260095 )
2015
27
Disparities in the prenatal detection of critical congenital heart disease. ( 25989740 )
2015
28
Screening for Critical Congenital Heart Disease in Newborns. ( 26205115 )
2015
29
Early versus delayed surgical correction of malrotation in children with critical congenital heart disease. ( 25598100 )
2015
30
Evaluating cost and resource use associated with pulse oximetry screening for critical congenital heart disease: Empiric estimates and sources of variation. ( 26215888 )
2015
31
Voluntary implementation of critical congenital heart disease screening in washington hospitals. ( 25832974 )
2015
32
Pulse oximetry as a screening test for critical congenital heart disease in term newborns. ( 25938847 )
2015
33
Implications of Using Pulse Oximetry to Screen for Critical Congenital Heart Disease in Newborns. ( 26264796 )
2015
34
Amplitude-Integrated EEG in Newborns With Critical Congenital Heart Disease Predicts Preoperative Brain Magnetic Resonance Imaging Findings. ( 25838043 )
2015
35
Pulse oximetry screening for critical congenital heart disease in the neonatal intensive care unit. ( 26540249 )
2015
36
Timing of diagnosis affects mortality in critical congenital heart disease. ( 26130379 )
2015
37
Pulse Oximetry Screening of Critical Congenital Heart Disease. ( 26244967 )
2015
38
Comment on "Outcomes of critical congenital heart disease requiring emergent neonatal cardiac intervention": a new classification of congenital heart disease. ( 26041254 )
2015
39
Comparing Retesting Rates Between Different Screening Methods for Critical Congenital Heart Disease: A Case from Northeast Brazil. ( 26008762 )
2015
40
Critical congenital heart disease screening practices among licensed midwives in washington state. ( 25782853 )
2015
41
Beyond Critical Congenital Heart Disease: Newborn Screening Using Pulse Oximetry for Neonatal Sepsis and Respiratory Diseases in a Middle-Income Country. ( 26360420 )
2015
42
Quality improvement in screening for critical congenital heart disease. ( 24120017 )
2014
43
Identification of Critical Congenital Heart Disease in Vermont: The Role of Universal Pulse Oximetry Screening in a Rural State. ( 25398625 )
2014
44
Pulse oximetry screening for critical congenital heart disease in planned out-of-hospital births. ( 24948344 )
2014
45
Outcomes of critical congenital heart disease requiring emergent neonatal cardiac intervention. ( 24947130 )
2014
46
Cardiology patient page. Screening for critical congenital heart disease in newborns. ( 25156919 )
2014
47
A public health economic assessment of hospitals' cost to screen newborns for critical congenital heart disease. ( 24381364 )
2014
48
Critical congenital heart disease screening tools may reduce neonatal deaths. ( 25585444 )
2014
49
U.S. international efforts on critical congenital heart disease screening: can we have a uniform recommendation for Europe? ( 25220118 )
2014
50
Age at referral and mortality from critical congenital heart disease. ( 24982105 )
2014

Variations for Critical Congenital Heart Disease

Expression for Critical Congenital Heart Disease

Search GEO for disease gene expression data for Critical Congenital Heart Disease.

Pathways for Critical Congenital Heart Disease

GO Terms for Critical Congenital Heart Disease

Sources for Critical Congenital Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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