MCID: CRT057
MIFTS: 19

Critical Congenital Heart Disease

Aliases & Classifications for Critical Congenital Heart Disease

MalaCards integrated aliases for Critical Congenital Heart Disease:

Name: Critical Congenital Heart Disease 25
Critical Congenital Heart Defects 25
Cchd 25

Summaries for Critical Congenital Heart Disease

Genetics Home Reference : 25 Critical congenital heart disease (CCHD) is a term that refers to a group of serious heart defects that are present from birth. These abnormalities result from problems with the formation of one or more parts of the heart during the early stages of embryonic development. CCHD prevents the heart from pumping blood effectively or reduces the amount of oxygen in the blood. As a result, organs and tissues throughout the body do not receive enough oxygen, which can lead to organ damage and life-threatening complications. Individuals with CCHD usually require surgery soon after birth.

MalaCards based summary : Critical Congenital Heart Disease, also known as critical congenital heart defects, is related to heart disease and brain injury. The drugs Heparin and Anticoagulants have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney.

Related Diseases for Critical Congenital Heart Disease

Diseases related to Critical Congenital Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 heart disease 10.7
2 brain injury 9.9
3 birth defects 9.8

Symptoms & Phenotypes for Critical Congenital Heart Disease

Drugs & Therapeutics for Critical Congenital Heart Disease

Drugs for Critical Congenital Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2 Anticoagulants Phase 4,Phase 1
3 calcium heparin Phase 4
4 Calcium, Dietary Phase 4
5 Fibrinolytic Agents Phase 4
6 Hemostatics Phase 4
7 Anesthetics Phase 3
8 Central Nervous System Depressants Phase 3
9
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
10
Glycerol Approved, Investigational Phase 2 56-81-5 753
11
Mineral oil Approved, Vet_approved Phase 2 8042-47-5
12
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
13
Iron Approved Phase 2 7439-89-6 23925
14
Butyric Acid Experimental Phase 2 107-92-6 264
15 Anti-Inflammatory Agents Phase 2
16 Cortisol succinate Phase 2
17 Hydrocortisone 17-butyrate 21-propionate Phase 2
18 Hydrocortisone acetate Phase 2
19 Hydrocortisone-17-butyrate Phase 2
20 Calcium polycarbophil Phase 2
21 Carbopol 940 Phase 2
22 Hormone Antagonists Phase 2
23 Hormones Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
25 Progestins Phase 2
26 Pharmaceutical Solutions Phase 2
27 Psyllium Nutraceutical Phase 2
28 Antithrombin III Phase 1
29 Antithrombins Phase 1
30 HIV Protease Inhibitors Phase 1
31
protease inhibitors Phase 1
32 Serine Proteinase Inhibitors Phase 1
33 serine Nutraceutical Phase 1
34
Isoflurane Approved, Vet_approved 26675-46-7 3763
35
Sufentanil Approved, Investigational 56030-54-7 41693
36
Benzocaine Approved 1994-09-7, 94-09-7 2337
37 tannic acid Approved, Nutraceutical
38 Micronutrients
39 Trace Elements
40 Adjuvants, Anesthesia
41 Analgesics
42 Analgesics, Opioid
43 Anesthetics, General
44 Anesthetics, Intravenous
45 Narcotics
46 Peripheral Nervous System Agents
47 Antibodies
48 gamma-Globulins
49 Immunoglobulins
50 Immunoglobulins, Intravenous

Interventional clinical trials:

(show all 31)

id Name Status NCT ID Phase Drugs
1 Platelet Function With New Pediatric Oxygenator and Heparin and Non Heparin Coating in Pediatric Cardiac Surgery Unknown status NCT01648712 Phase 4
2 Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02222532 Phase 3 Tetronine;Placebo
3 Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease Completed NCT00590018 Phase 2 Hydrocortisone;Placebo
4 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2 Progesterone;Vaginal lubricant
5 Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery Recruiting NCT02046135 Phase 2 Sodium Bicarbonate;Sodium Chloride
6 Impact of Early Enteral Feeding on Splanchnic Blood Flow After Surgery for Critical Heart Disease in the Newborn Terminated NCT00919945 Phase 2
7 Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support Recruiting NCT02631174 Phase 1 Antithrombin III
8 Prospective Analysis of Cerebral Perfusion Using Head Ultrasound and Multi-source-detector Near Infrared Spectroscopy (NIRS) Imaging Unknown status NCT01082536
9 The Impact of Implementing a Universal Newborn Screening for Critical Congenital Heart Disease Completed NCT01749059
10 Newborn Screening for Critical Congenital Heart Disease Completed NCT01765205 Early Phase 1
11 Leuven Growing Into Deficit Follow-up Study Completed NCT01632813
12 Micronutrients in Children in Critical Care With Cardiac Conditions Completed NCT02409706
13 Biventricular Pacing in Children After Surgery for Congenital Heart Disease Completed NCT02806245
14 Hypoxemia in Infants After Palliative Surgery Completed NCT00327977
15 A Critical Appraisal of the Role of Near Infrared Spectroscopy (NIRS) in the Pediatric Intensive Care Unit (PICU) Completed NCT01282099
16 Hybrid Closure of Congenital Heart Disease Completed NCT02794584 sufentanil anesthesia
17 Post-bypass Prophylactic IVIG in Infants and Neonates Completed NCT02043379 IVIG
18 Evaluation of Panel Reactive Antibody in Children Following Stage I Palliation for Hypoplastic Left Heart Syndrome Completed NCT01135485
19 An Intervention to Reduce Delirium After Cardiac Surgery Completed NCT02587039
20 Pulse Oximeter Screening in Congenital Heart Disease Recruiting NCT02731248
21 Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study Recruiting NCT03023644
22 Genetic Determinants of Congenital Heart Disease Outcomes Recruiting NCT01656941
23 Biventricular Pacing in Children With Congenital Heart Disease Recruiting NCT02644824
24 Improving Neurodevelopment in Adolescents With Congenital Heart Disease Recruiting NCT02759263
25 Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study) Recruiting NCT02184169
26 Right Lateral Positioning of Postoperative Pediatric Cardiac Surgery Recruiting NCT02622152
27 SVR III: Brain Connectome and Neurodevelopmental Outcomes Enrolling by invitation NCT02692443
28 Brain Function in Children With Congenital Heart Disease (CHD) Enrolling by invitation NCT02814539
29 Health-economic Impact of Pulse Oximetry Systematic Screening of Critical Congenital Heart Disease in Asymptomatic Newborns Not yet recruiting NCT03078218
30 ATrial Tachycardia PAcing Therapy in Congenital Heart Not yet recruiting NCT03209583
31 Critical Congenital Heart Defect (CHD) Outcomes in Children Terminated NCT00208689

Search NIH Clinical Center for Critical Congenital Heart Disease

Genetic Tests for Critical Congenital Heart Disease

Anatomical Context for Critical Congenital Heart Disease

MalaCards organs/tissues related to Critical Congenital Heart Disease:

39
Heart, Brain, Kidney, Testes

Publications for Critical Congenital Heart Disease

Articles related to Critical Congenital Heart Disease:

(show top 50) (show all 139)
id Title Authors Year
1
Should New Zealand introduce nationwide pulse oximetry screening for the detection of critical congenital heart disease in newborn infants? ( 28081558 )
2017
2
Retinovascular findings in newborns with critical congenital heart disease: A case series. ( 28504505 )
2017
3
Transfer of Neonates with Critical Congenital Heart Disease Within a Regionalized Network. ( 28711963 )
2017
4
A National Call to Action-Improving the Detection of Critical Congenital Heart Disease. ( 28129863 )
2017
5
Critical congenital heart disease screening with a pulse oximetry in neonates. ( 28672762 )
2017
6
The role of palliative care in critical congenital heart disease. ( 28189331 )
2017
7
The limitations of pulse oximetry for critical congenital heart disease screening in the neonatal intensive care units. ( 28075515 )
2017
8
Pulse oximetry is a feasible method for detecting neonatal critical congenital heart disease. ( 28235129 )
2017
9
Texas Pulse Oximetry Project: A Multicenter Educational and Quality Improvement Project for Implementation of Critical Congenital Heart Disease Screening Using Pulse Oximetry. ( 28264208 )
2017
10
A Post-operative Feeding Protocol to Improve Outcomes for Neonates With Critical Congenital Heart Disease. ( 28063770 )
2017
11
CDC Grand Rounds: Newborn Screening for Hearing Loss and Critical Congenital Heart Disease. ( 28837548 )
2017
12
Critical Congenital Heart Disease Newborn Screening Implementation: Lessons Learned. ( 28092064 )
2017
13
Visuospatial processing in adolescents with critical congenital heart disease: Organization, integration, and implications for academic achievement. ( 28277152 )
2017
14
Public Views on Pulse Oximetry Screening for Critical Congenital Heart Disease. ( 28329450 )
2017
15
Effectiveness of the critical congenital heart disease screening program for early diagnosis of cardiac abnormalities in newborn infants. ( 28917066 )
2017
16
Critical Congenital Heart Disease Screening in NICU: Need for Revision and Standardization. ( 28614866 )
2017
17
The association between cardiac physiology, acquired brain injury, and postnatal brain growth in critical congenital heart disease. ( 28918207 )
2017
18
A Multicenter Initiative for Critical Congenital Heart Disease Newborn Screening in Texas Neonatal Intensive Care Units. ( 28212589 )
2017
19
Gestational Age and Outcomes in Critical Congenital Heart Disease. ( 28885171 )
2017
20
Letting Parents Say "No:" A Small Price to Pay for State-Mandated Critical Congenital Heart Disease (CCHD) Screening. ( 26734737 )
2016
21
Association of Prenatal Diagnosis of Critical Congenital Heart Disease With Postnatal Brain Development and the Risk of Brain Injury. ( 26902528 )
2016
22
Giant dissecting ventricular septal haematoma associated with critical congenital heart disease. ( 27365006 )
2016
23
Pediatric Resident Attitudes and Knowledge of Critical Congenital Heart Disease Screening. ( 27160097 )
2016
24
A novel, more efficient, staged approach for critical congenital heart disease screening. ( 27831548 )
2016
25
Parents Do Not Always Have to Get Their Way: Why Critical Congenital Heart Disease Screening for Newborns Should Be Mandatory. ( 26734746 )
2016
26
Is Pulse Oximetry Useful for Screening Neonates for Critical Congenital Heart Disease at High Altitudes? ( 27090652 )
2016
27
Pulse Oximetry Overestimates Oxyhemoglobin in Neonates with Critical Congenital Heart Disease. ( 26800085 )
2016
28
Screening for Critical Congenital Heart Disease. ( 26876122 )
2016
29
Newborn Critical Congenital Heart Disease Screening Using Pulse Oximetry: Nursing Aspects. ( 27603538 )
2016
30
Pulse oximetry screening for critical congenital heart disease in planned out of hospital births and the incidence of critical congenital heart disease in the Plain community. ( 27583398 )
2016
31
Pulse oximetry screening: a review of diagnosing critical congenital heart disease in newborns. ( 27468253 )
2016
32
Antenatal diagnosis of critical congenital heart disease. Optimal place of delivery is where appropriate care can be delivered. ( 26819268 )
2016
33
Legal and Ethical Considerations in Allowing Parental Exemptions From Newborn Critical Congenital Heart Disease (CCHD) Screening. ( 26734736 )
2016
34
Complications of Long-Term Prostaglandin E1 Use in Newborns With Ductal-Dependent Critical Congenital Heart Disease. ( 26813395 )
2016
35
Pulse Oximetry Screening for Critical Congenital Heart Disease after Home Birth and Early Discharge. ( 26746119 )
2016
36
Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Position Statement on Pulse Oximetry Screening in Newborns to Enhance Detection of Critical Congenital Heart Disease. ( 28043739 )
2016
37
Universal Pulse Oximetry Screening for Early Detection of Critical Congenital Heart Disease. ( 27279759 )
2016
38
Pulse oximetry could significantly enhance the early detection of critical congenital heart disease in neonatal intensive care units. ( 27540721 )
2016
39
Critical congenital heart disease screening. ( 27390667 )
2016
40
Development of a Newborn Screening Program for Critical Congenital Heart Disease (CCHD) in Taipei. ( 27073996 )
2016
41
Voluntary implementation of critical congenital heart disease screening in washington hospitals. ( 25832974 )
2015
42
Beyond Critical Congenital Heart Disease: Newborn Screening Using Pulse Oximetry for Neonatal Sepsis and Respiratory Diseases in a Middle-Income Country. ( 26360420 )
2015
43
Implications of Using Pulse Oximetry to Screen for Critical Congenital Heart Disease in Newborns. ( 26264796 )
2015
44
Pulse oximetry screening for critical congenital heart disease in the neonatal intensive care unit. ( 26540249 )
2015
45
Evaluating cost and resource use associated with pulse oximetry screening for critical congenital heart disease: Empiric estimates and sources of variation. ( 26215888 )
2015
46
Critical congenital heart disease screening practices among licensed midwives in washington state. ( 25782853 )
2015
47
Long-Term Prostaglandin E1 Infusion for Newborns with Critical Congenital Heart Disease. ( 26260095 )
2015
48
Comparing Retesting Rates Between Different Screening Methods for Critical Congenital Heart Disease: A Case from Northeast Brazil. ( 26008762 )
2015
49
Pulse Oximetry Screening of Critical Congenital Heart Disease. ( 26244967 )
2015
50
Amplitude-Integrated EEG in Newborns With Critical Congenital Heart Disease Predicts Preoperative Brain Magnetic Resonance Imaging Findings. ( 25838043 )
2015

Variations for Critical Congenital Heart Disease

Expression for Critical Congenital Heart Disease

Search GEO for disease gene expression data for Critical Congenital Heart Disease.

Pathways for Critical Congenital Heart Disease

GO Terms for Critical Congenital Heart Disease

Sources for Critical Congenital Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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