MCID: CRT009
MIFTS: 44

Critical Illness Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

MalaCards integrated aliases for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 12 14
Polyneuropathy, Critical Illness 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14402
ICD10 32 G62.81
ICD9CM 34 357.82
MeSH 41 D011115
SNOMED-CT 64 230594005
UMLS 69 C0393851

Summaries for Critical Illness Polyneuropathy

MalaCards based summary : Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to polyneuropathy and myopathy. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways/superpathways are TNF signaling pathway and AGE-RAGE signaling pathway in diabetic complications. The drugs Zinc and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and heart, and related phenotypes are cardiovascular system and behavior/neurological

Wikipedia : 72 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

Related Diseases for Critical Illness Polyneuropathy

Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 polyneuropathy 10.8
2 myopathy 10.5
3 maturity-onset diabetes of the young, type 2 10.5 GCK INS
4 inflammatory and toxic neuropathy 10.5 INS PNMT SCN4A
5 tungiasis 10.4 NDUFS3 TNF
6 heavy chain disease 10.4 CD40LG PNMT
7 lymphocytic vasculitis 10.3 ICAM1 SELE
8 cat-scratch disease 10.3 CD40LG CS
9 trench fever 10.2 CD40LG TNF
10 encephalitozoonosis 10.2 CD40LG TNF
11 glucose metabolism disease 10.2 GCK INS TNF
12 rheumatoid lung disease 10.2 CD40LG TNF
13 african tick-bite fever 10.2 CD40LG SELE
14 acquired metabolic disease 10.2 GCK INS TNF
15 pustulosis palmaris et plantaris 10.2 CD40LG SELE TNF
16 sleep apnea 10.2 ICAM1 INS TNF
17 actinic prurigo 10.2 ICAM1 SELE TNF
18 rheumatoid vasculitis 10.2 ICAM1 SELE TNF
19 cytomegalovirus infection 10.1 ICAM1 SELE TNF
20 takayasu arteritis 10.1 CD40LG SELE TNF
21 miller fisher syndrome 10.1 CD40LG TNF
22 allergic contact dermatitis 10.1 ICAM1 SELE TNF
23 gastrointestinal system disease 10.1 CD40LG INS TNF
24 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 ICAM1 SELE TNF
25 heterophyiasis 10.1 CD40LG ICAM1 SELE
26 contact dermatitis 10.1 ICAM1 SELE TNF
27 female reproductive system disease 10.1 INS OXT TNF
28 hypersensitivity reaction type iii disease 10.1 CD40LG ICAM1 SELE
29 plasmodium falciparum malaria 10.1 ICAM1 SELE TNF
30 neuropathy 10.1
31 synovitis 10.1 ICAM1 SELE TNF
32 reproductive system disease 10.1 INS OXT TNF
33 lichen disease 10.1 CD40LG ICAM1 TNF
34 parasitic protozoa infectious disease 10.1 CD40LG ICAM1 TNF
35 endometritis 10.1 OXT SELE TNF
36 arteries, anomalies of 10.0 ICAM1 INS SELE TNF
37 atherosclerosis susceptibility 10.0 ICAM1 INS SELE TNF
38 urinary system disease 10.0 CABIN1 CD40LG INS TNF
39 myocarditis 10.0 CD40LG ICAM1 TNF
40 cerebrovascular disease 10.0 ICAM1 INS SELE TNF
41 mooren's ulcer 10.0 ICAM1 SELE
42 middle ear disease 10.0 CD40LG MUC5AC TNF
43 respiratory failure 10.0
44 encephalopathy 10.0
45 factitious disorder 10.0 GCK INS
46 dermatitis, atopic 10.0 ICAM1 IL16 SELE TNF
47 demyelinating disease 10.0 CD40LG ICAM1 TNF
48 otitis media 10.0 CD40LG MUC5AC TNF
49 plasmodium vivax malaria 9.9 CD40LG ICAM1 SELE TNF
50 cutaneous lupus erythematosus 9.9 CD40LG ICAM1 SELE TNF

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to Critical Illness Polyneuropathy

Symptoms & Phenotypes for Critical Illness Polyneuropathy

MGI Mouse Phenotypes related to Critical Illness Polyneuropathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 CD40LG ICAM1 INS MDK MSTN NDUFS3
2 behavior/neurological MP:0005386 10.22 INS MDK MSTN MUC5AC NDUFS3 OXT
3 growth/size/body region MP:0005378 10.18 GCK ICAM1 INS MDK MSTN NDUFS3
4 homeostasis/metabolism MP:0005376 10.17 CD40LG GCK ICAM1 INS MDK MSTN
5 hematopoietic system MP:0005397 10.15 CABIN1 CD40LG GCK ICAM1 IL16 INS
6 immune system MP:0005387 10.03 MUC5AC PCLAF POLB SELE TNF INS
7 digestive/alimentary MP:0005381 9.98 ICAM1 INS MSTN MUC5AC OXT POLB
8 mortality/aging MP:0010768 9.8 CABIN1 CD40LG CS GCK ICAM1 INS
9 liver/biliary system MP:0005370 9.7 GCK INS MDK MSTN POLB SELE
10 renal/urinary system MP:0005367 9.17 CD40LG GCK INS MDK MSTN OXT

Drugs & Therapeutics for Critical Illness Polyneuropathy

Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 3 7440-66-6 32051 23994
2
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
3
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
4
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
5
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
6
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
7 insulin Phase 3
8 Hypoglycemic Agents Phase 3
9 Pharmaceutical Solutions Phase 3
10 Insulin, Globin Zinc Phase 3
11 Testosterone undecanoate Phase 2, Phase 3
12
Testosterone enanthate Phase 2, Phase 3 315-37-7 9416
13 Testosterone 17 beta-cypionate Phase 2, Phase 3
14 Anabolic Agents Phase 2, Phase 3
15 Androgens Phase 2, Phase 3
16 Hormone Antagonists Phase 2, Phase 3
17 Hormones Phase 2, Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
19 Antineoplastic Agents, Hormonal Phase 2, Phase 3
20 Analgesics Phase 3
21 Central Nervous System Depressants Phase 3
22 Adrenergic Agents Phase 3
23 Adrenergic Agonists Phase 3
24 Adrenergic alpha-2 Receptor Agonists Phase 3
25 Adrenergic alpha-Agonists Phase 3
26 Neurotransmitter Agents Phase 3
27 Analgesics, Non-Narcotic Phase 3
28 Peripheral Nervous System Agents Phase 3
29 Hypnotics and Sedatives Phase 3
30 Rho(D) Immune Globulin Phase 1
31 gamma-Globulins Phase 1
32 Immunoglobulins Phase 1
33 Immunoglobulins, Intravenous Phase 1
34 Antibodies Phase 1
35 Anesthetics
36 Cola Nutraceutical

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Tight Glycemic Control in Critical Care Patients Completed NCT00096421 Phase 3
2 Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) Completed NCT00135473 Phase 3 10% Hemohes® (10% Hydroxyethyl starch);Sterofundin® (Ringer lactate solution);Actrapid® (Insulin)
3 Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness Recruiting NCT03038919 Phase 2, Phase 3 Testosterone cypionate
4 Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness Assessment Recruiting NCT02706587 Phase 3
5 Dexmedetomidine for Continuous Sedation Terminated NCT00226785 Phase 3 Dexmedetomidine
6 Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M) Completed NCT00614562 Phase 1
7 The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis Terminated NCT01867645 Phase 1 IgM-enriched Intravenous Immunoglobulins;Human Albumin
8 Neurological Outcome in Surgical and Non-surgical Septic Patients Completed NCT02442986
9 Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit Recruiting NCT02763709
10 Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks. Recruiting NCT02706314
11 Neuromuscular Electrical Stimulation in the Critically Ill Recruiting NCT02566941
12 Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock Recruiting NCT03258619
13 In-Bed Cycling in ICU Patients Post Cardiac Surgery Recruiting NCT02976415
14 Amino Acid Metabolism in Fed Surgical Critically Ill Patients Not yet recruiting NCT03451968

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

Anatomical Context for Critical Illness Polyneuropathy

MalaCards organs/tissues related to Critical Illness Polyneuropathy:

38
Testes, Colon, Heart, Liver, Brain

Publications for Critical Illness Polyneuropathy

Articles related to Critical Illness Polyneuropathy:

(show top 50) (show all 128)
# Title Authors Year
1
Functional outcome of critical illness polyneuropathy in patients affected by severe brain injury. ( 28417610 )
2017
2
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability. ( 27207148 )
2016
3
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features. ( 27978832 )
2016
4
Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. ( 27856098 )
2016
5
Recovery After Critical Illness Polyneuropathy in a Patient With Orthotopic Liver Transplantation: A Case Report. ( 27932182 )
2016
6
Critical illness polyneuropathy and myopathy 20A years later. No man's land? No, it is our land! ( 27502507 )
2016
7
Acute Physiology and Chronic Health Evaluation II score of a8Y15: A risk factor for sepsis-induced critical illness polyneuropathy. ( 27381107 )
2016
8
Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy. ( 25916937 )
2015
9
Dysphagia diagnosed by fiberoptic endoscopy is common and transient in critical illness polyneuropathy: are there any clinical implications? ( 25599480 )
2015
10
Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness myopathy. ( 26311145 )
2015
11
513: CRITICAL ILLNESS POLYNEUROPATHY AND MYOPATHY IN THE PICU. ( 26570174 )
2015
12
Critical illness polyneuropathy and myopathy in a rural area in Vietnam. ( 26276515 )
2015
13
Bilateral Diaphragmatic Paralysis in a Patient With Critical Illness Polyneuropathy: A Case Report. ( 26252301 )
2015
14
Critical illness polyneuropathy and myopathy: a systematic review. ( 25206749 )
2014
15
Intensive care unit-related generalized neuromuscular weakness due to critical illness polyneuropathy/myopathy in critically ill patients. ( 24981564 )
2014
16
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. ( 24477672 )
2014
17
A rare case of critical illness polyneuropathy and literature review. ( 24949002 )
2014
18
Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study. ( 25309729 )
2014
19
Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. ( 24678152 )
2014
20
Dysphagia-A Common, Transient Symptom in Critical Illness Polyneuropathy: A Fiberoptic Endoscopic Evaluation of Swallowing Study. ( 25377021 )
2014
21
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. Response. ( 23667929 )
2013
22
Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. ( 23312812 )
2013
23
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. ( 23373568 )
2013
24
Lower urinary tract dysfunction in critical illness polyneuropathy. ( 23949055 )
2013
25
Critical illness polyneuropathy and myopathy are common neuromuscular complications secondary to sepsis. ( 22307447 )
2013
26
"Dry" and "wet" beriberi mimicking critical illness polyneuropathy. ( 24339610 )
2013
27
Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial. ( 24088271 )
2013
28
Critical-illness-polyneuropathy as sequelae of severe neurological illness: incidence and impact on ventilator therapy and rehabilitation. ( 23422468 )
2013
29
Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy - a single center controlled observational study. ( 24176121 )
2013
30
Reversible tetraplegia after percutaneous nephrostolithotomy and septic shock: a case of critical illness polyneuropathy and myopathy with acute onset and complete recovery. ( 23409743 )
2013
31
Strategies to prevent sepsis-induced intensive care unit-acquired weakness: are there any options? Commentary on "Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with surgically induced sepsis". ( 23295195 )
2013
32
Is critical illness polyneuropathy associated with decreased heart rate variability? ( 24230479 )
2013
33
The critical illness polyneuropathy in septic patients with prolonged weaning from mechanical ventilation: is the diaphragm also affected? A pilot study. ( 22417531 )
2012
34
Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. ( 23094903 )
2012
35
Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia. ( 22246161 )
2012
36
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review. ( 23158890 )
2012
37
Successful management of critical illness polyneuropathy and myopathy in renal transplant recipients. ( 22309422 )
2012
38
Rehabilitation of critical illness polyneuropathy and myopathy patients: an observational study. ( 22067549 )
2011
39
Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy? ( 22018206 )
2011
40
Critical illness polyneuropathy: a case report. ( 22142755 )
2011
41
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. ( 21939902 )
2011
42
Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology. ( 19760771 )
2010
43
Management of critical illness polyneuropathy and myopathy. ( 20816273 )
2010
44
Critical illness polyneuropathy in patients with major burn injuries. ( 21119768 )
2010
45
The discovery of critical illness polyneuropathy: a memoir. ( 20724249 )
2010
46
Critical illness polyneuropathy after septic peritonitis in a boy with nephrotic syndrome. ( 20232085 )
2010
47
Facial nerve involvement in critical illness polyneuropathy. ( 21189890 )
2010
48
Electrical muscle stimulation for prevention of critical illness polyneuropathy. ( 20624326 )
2010
49
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. ( 19160304 )
2009
50
Critical illness polyneuropathy and myopathy in the intensive care unit. ( 19578344 )
2009

Variations for Critical Illness Polyneuropathy

Expression for Critical Illness Polyneuropathy

Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for Critical Illness Polyneuropathy

GO Terms for Critical Illness Polyneuropathy

Cellular components related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 CD40LG ICAM1 IL16 INS MSTN MUC5AC
2 voltage-gated sodium channel complex GO:0001518 8.96 SCN4A SCN5A

Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 glucose metabolic process GO:0006006 9.61 GCK INS TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 CD40LG ICAM1 INS TNF
3 negative regulation of lipid catabolic process GO:0050995 9.52 INS TNF
4 regulation of protein secretion GO:0050708 9.51 INS TNF
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 ICAM1 INS TNF
6 leukocyte tethering or rolling GO:0050901 9.49 SELE TNF
7 positive regulation of glycogen biosynthetic process GO:0045725 9.48 GCK INS
8 negative regulation of gluconeogenesis GO:0045721 9.46 GCK INS
9 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.4 ICAM1 TNF
10 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
11 leukocyte cell-cell adhesion GO:0007159 9.33 CD40LG ICAM1 SELE
12 response to glucocorticoid GO:0051384 9.26 MDK MSTN OXT TNF
13 regulation of receptor activity GO:0010469 9.17 CD40LG IL16 INS MDK MSTN OXT

Molecular functions related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CD40LG IL16 MSTN TNF

Sources for Critical Illness Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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