MCID: CRT009
MIFTS: 40

Critical Illness Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

MalaCards integrated aliases for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 12 14
Polyneuropathy, Critical Illness 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14402
ICD10 33 G62.81
ICD9CM 35 357.82
MeSH 42 D011115
SNOMED-CT 64 230594005
UMLS 69 C0393851

Summaries for Critical Illness Polyneuropathy

MalaCards based summary : Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to dysphagia and polyneuropathy. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways/superpathways are TNF signaling pathway and AGE-RAGE signaling pathway in diabetic complications. The drugs Zinc and Methyltestosterone have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and heart, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 72 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

Related Diseases for Critical Illness Polyneuropathy

Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Related Disease Score Top Affiliating Genes
1 dysphagia 30.2 ICAM1 SELE TNF
2 polyneuropathy 10.7
3 extratemporal epilepsy 10.7 INS PNMT SCN4A
4 gamma heavy chain disease 10.6 CD40LG PNMT
5 chlamydia 10.5 CD40LG CS
6 lymphomatous thyroiditis 10.5 ICAM1 SELE
7 rickettsialpox 10.5 CD40LG TNF
8 indian tick typhus 10.5 CD40LG SELE
9 myopathy 10.5
10 lung disease 10.5 CD40LG TNF
11 submandibular gland disease 10.4 CD40LG TNF
12 hypertrichosis 10.4 GCK INS TNF
13 survival motor neuron spinal muscular atrophy 10.4 GCK INS TNF
14 spotted fever 10.4 CD40LG CS
15 labyrinthine unilateral reactive loss 10.3 GCK INS
16 diabetic encephalopathy 10.3 ICAM1 INS TNF
17 pyridoxine deficiency 10.3 CD40LG SELE TNF
18 periampullary adenoma 10.3 ICAM1 INS TNF
19 tuberculum sellae meningioma 10.3 CD40LG INS TNF
20 moved to 244450 10.3 ICAM1 SELE TNF
21 riboflavin transporter deficiency 10.3 ICAM1 SELE TNF
22 emphysema, congenital lobar 10.3 CD40LG SELE TNF
23 marginal corneal ulcer 10.3 ICAM1 SELE
24 churg-strauss syndrome 10.3 ICAM1 SELE TNF
25 ragweed sensitivity 10.3 ICAM1 SELE TNF
26 cerebellar disease 10.3 ICAM1 SELE TNF
27 hodgkin's lymphoma, nodular sclerosis 10.2 CD40LG ICAM1 SELE
28 spondylolysis 10.2 INS OXT TNF
29 geniculate ganglionitis 10.2 ICAM1 SELE TNF
30 synovium cancer 10.2 ICAM1 SELE TNF
31 avoidant personality disorder 10.2 INS OXT TNF
32 uveitis 10.2 CD40LG ICAM1 TNF
33 acute vascular insufficiency of intestine 10.2 CD40LG ICAM1 TNF
34 acute interstitial pneumonia 10.2 CD40LG ICAM1 TNF
35 ampulla of vater neoplasm 10.2 OXT SELE TNF
36 polysyndactyly with cardiac malformation 10.2 CABIN1 MUC5AC
37 pseudohypoparathyroidism 10.1 CD40LG INS TNF
38 lung superior sulcus carcinoma 10.1 CD40LG ICAM1 TNF
39 malignant type ab thymoma 10.1 ICAM1 INS SELE TNF
40 calcinosis 10.1 CABIN1 CD40LG INS TNF
41 testicular infarct 10.1 CD40LG MUC5AC TNF
42 peripheral artery disease 10.1 ICAM1 INS SELE TNF
43 causalgia 10.1 CD40LG ICAM1 TNF
44 cataract 10.1 INS TNF
45 premature ovarian failure 12 10.0 CD40LG MUC5AC TNF
46 neuropathy 10.0
47 myelophthisic anemia 10.0 ICAM1 INS SELE
48 dermatomycosis 9.9 CD40LG ICAM1 SELE TNF
49 conduct disorder 9.9 CD40LG ICAM1 SELE TNF
50 tick-borne encephalitis 9.9 CD40LG ICAM1 SELE TNF

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to Critical Illness Polyneuropathy

Symptoms & Phenotypes for Critical Illness Polyneuropathy

MGI Mouse Phenotypes related to Critical Illness Polyneuropathy:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.19 OXT POLB SCN4A SCN5A SELE TNF
2 cardiovascular system MP:0005385 10.18 CD40LG ICAM1 INS MDK MSTN OXT
3 homeostasis/metabolism MP:0005376 10.18 ICAM1 INS MDK MSTN MUC5AC OXT
4 hematopoietic system MP:0005397 10.14 PCLAF POLB SELE TNF CABIN1 CD40LG
5 growth/size/body region MP:0005378 10.13 GCK ICAM1 INS MSTN OXT POLB
6 immune system MP:0005387 10.1 CABIN1 CD40LG ICAM1 IL16 INS MDK
7 digestive/alimentary MP:0005381 10 ICAM1 INS MSTN MUC5AC OXT POLB
8 mortality/aging MP:0010768 10 POLB SCN4A SCN5A SELE TNF CABIN1
9 liver/biliary system MP:0005370 9.8 GCK INS MDK MSTN POLB SELE
10 muscle MP:0005369 9.43 ICAM1 INS MSTN SCN4A SCN5A TNF
11 renal/urinary system MP:0005367 9.17 OXT POLB CD40LG GCK INS MDK

Drugs & Therapeutics for Critical Illness Polyneuropathy

Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 3 7440-66-6 32051 23994
2
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
3
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
4
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
5
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
6
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
7 insulin Phase 3
8 Insulin, Globin Zinc Phase 3
9 Hypoglycemic Agents Phase 3
10 Pharmaceutical Solutions Phase 3
11 Anabolic Agents Phase 2, Phase 3
12 Androgens Phase 2, Phase 3
13 Antineoplastic Agents, Hormonal Phase 2, Phase 3
14 Hormone Antagonists Phase 2, Phase 3
15 Hormones Phase 2, Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
17 Testosterone 17 beta-cypionate Phase 2, Phase 3
18
Testosterone enanthate Phase 2, Phase 3 315-37-7 9416
19 Testosterone undecanoate Phase 2, Phase 3
20 Adrenergic Agents Phase 3
21 Adrenergic Agonists Phase 3
22 Adrenergic alpha-2 Receptor Agonists Phase 3
23 Adrenergic alpha-Agonists Phase 3
24 Analgesics Phase 3
25 Analgesics, Non-Narcotic Phase 3
26 Central Nervous System Depressants Phase 3
27 Hypnotics and Sedatives Phase 3
28 Neurotransmitter Agents Phase 3
29 Peripheral Nervous System Agents Phase 3
30 Antibodies Phase 1
31 gamma-Globulins Phase 1
32 Immunoglobulins Phase 1
33 Immunoglobulins, Intravenous Phase 1
34 Rho(D) Immune Globulin Phase 1
35 Anesthetics
36 Cola Nutraceutical

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
2 Tight Glycemic Control in Critical Care Patients Completed NCT00096421 Phase 3
3 Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) Completed NCT00135473 Phase 3 10% Hemohes® (10% Hydroxyethyl starch);Sterofundin® (Ringer lactate solution);Actrapid® (Insulin)
4 Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness Recruiting NCT03038919 Phase 2, Phase 3 Testosterone cypionate
5 Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness Assessment Recruiting NCT02706587 Phase 3
6 Dexmedetomidine for Continuous Sedation Terminated NCT00226785 Phase 3 Dexmedetomidine
7 Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M) Completed NCT00614562 Phase 1
8 The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis Terminated NCT01867645 Phase 1 IgM-enriched Intravenous Immunoglobulins;Human Albumin
9 Neurological Outcome in Surgical and Non-surgical Septic Patients Completed NCT02442986
10 New Onset Weakness in Critically Ill Patients and the Risk of Death and Recurrent ICU Admission Completed NCT00106665
11 Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit Recruiting NCT02763709
12 Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks. Recruiting NCT02706314
13 Neuromuscular Electrical Stimulation in the Critically Ill Recruiting NCT02566941
14 Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock Recruiting NCT03258619
15 In-Bed Cycling in ICU Patients Post Cardiac Surgery Not yet recruiting NCT02976415

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

Anatomical Context for Critical Illness Polyneuropathy

MalaCards organs/tissues related to Critical Illness Polyneuropathy:

39
Testes, Colon, Heart, Liver, Brain

Publications for Critical Illness Polyneuropathy

Articles related to Critical Illness Polyneuropathy:

(show top 50) (show all 128)
id Title Authors Year
1
Functional outcome of critical illness polyneuropathy in patients affected by severe brain injury. ( 28417610 )
2017
2
Critical illness polyneuropathy and myopathy 20A years later. No man's land? No, it is our land! ( 27502507 )
2016
3
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features. ( 27978832 )
2016
4
Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. ( 27856098 )
2016
5
Acute Physiology and Chronic Health Evaluation II score of a8Y15: A risk factor for sepsis-induced critical illness polyneuropathy. ( 27381107 )
2016
6
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability. ( 27207148 )
2016
7
Recovery After Critical Illness Polyneuropathy in a Patient With Orthotopic Liver Transplantation: A Case Report. ( 27932182 )
2016
8
Critical illness polyneuropathy and myopathy in a rural area in Vietnam. ( 26276515 )
2015
9
513: CRITICAL ILLNESS POLYNEUROPATHY AND MYOPATHY IN THE PICU. ( 26570174 )
2015
10
Dysphagia diagnosed by fiberoptic endoscopy is common and transient in critical illness polyneuropathy: are there any clinical implications? ( 25599480 )
2015
11
Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness myopathy. ( 26311145 )
2015
12
Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy. ( 25916937 )
2015
13
Bilateral Diaphragmatic Paralysis in a Patient With Critical Illness Polyneuropathy: A Case Report. ( 26252301 )
2015
14
Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study. ( 25309729 )
2014
15
Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. ( 24678152 )
2014
16
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. ( 24477672 )
2014
17
Critical illness polyneuropathy and myopathy: a systematic review. ( 25206749 )
2014
18
Intensive care unit-related generalized neuromuscular weakness due to critical illness polyneuropathy/myopathy in critically ill patients. ( 24981564 )
2014
19
A rare case of critical illness polyneuropathy and literature review. ( 24949002 )
2014
20
Dysphagia-A Common, Transient Symptom in Critical Illness Polyneuropathy: A Fiberoptic Endoscopic Evaluation of Swallowing Study. ( 25377021 )
2014
21
Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy - a single center controlled observational study. ( 24176121 )
2013
22
Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. ( 23312812 )
2013
23
Is critical illness polyneuropathy associated with decreased heart rate variability? ( 24230479 )
2013
24
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. Response. ( 23667929 )
2013
25
"Dry" and "wet" beriberi mimicking critical illness polyneuropathy. ( 24339610 )
2013
26
Strategies to prevent sepsis-induced intensive care unit-acquired weakness: are there any options? Commentary on "Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with surgically induced sepsis". ( 23295195 )
2013
27
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. ( 23373568 )
2013
28
Reversible tetraplegia after percutaneous nephrostolithotomy and septic shock: a case of critical illness polyneuropathy and myopathy with acute onset and complete recovery. ( 23409743 )
2013
29
Critical-illness-polyneuropathy as sequelae of severe neurological illness: incidence and impact on ventilator therapy and rehabilitation. ( 23422468 )
2013
30
Lower urinary tract dysfunction in critical illness polyneuropathy. ( 23949055 )
2013
31
Critical illness polyneuropathy and myopathy are common neuromuscular complications secondary to sepsis. ( 22307447 )
2013
32
Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial. ( 24088271 )
2013
33
Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia. ( 22246161 )
2012
34
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review. ( 23158890 )
2012
35
The critical illness polyneuropathy in septic patients with prolonged weaning from mechanical ventilation: is the diaphragm also affected? A pilot study. ( 22417531 )
2012
36
Successful management of critical illness polyneuropathy and myopathy in renal transplant recipients. ( 22309422 )
2012
37
Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. ( 23094903 )
2012
38
Rehabilitation of critical illness polyneuropathy and myopathy patients: an observational study. ( 22067549 )
2011
39
Critical illness polyneuropathy: a case report. ( 22142755 )
2011
40
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. ( 21939902 )
2011
41
Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy? ( 22018206 )
2011
42
Critical illness polyneuropathy after septic peritonitis in a boy with nephrotic syndrome. ( 20232085 )
2010
43
Management of critical illness polyneuropathy and myopathy. ( 20816273 )
2010
44
Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology. ( 19760771 )
2010
45
Facial nerve involvement in critical illness polyneuropathy. ( 21189890 )
2010
46
Electrical muscle stimulation for prevention of critical illness polyneuropathy. ( 20624326 )
2010
47
Critical illness polyneuropathy in patients with major burn injuries. ( 21119768 )
2010
48
The discovery of critical illness polyneuropathy: a memoir. ( 20724249 )
2010
49
Critical illness polyneuropathy after Bacillus cereus sepsis in acute lymphoblastic leukemia. ( 19571454 )
2009
50
Critical illness polyneuropathy and myopathy in the intensive care unit. ( 19578344 )
2009

Variations for Critical Illness Polyneuropathy

Expression for Critical Illness Polyneuropathy

Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for Critical Illness Polyneuropathy

GO Terms for Critical Illness Polyneuropathy

Cellular components related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 CD40LG ICAM1 IL16 INS MSTN MUC5AC
2 voltage-gated sodium channel complex GO:0001518 8.96 SCN4A SCN5A

Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 glucose metabolic process GO:0006006 9.58 GCK INS TNF
2 negative regulation of lipid catabolic process GO:0050995 9.51 INS TNF
3 regulation of protein secretion GO:0050708 9.49 INS TNF
4 positive regulation of glycogen biosynthetic process GO:0045725 9.48 GCK INS
5 leukocyte tethering or rolling GO:0050901 9.46 SELE TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.46 CD40LG ICAM1 INS TNF
7 negative regulation of gluconeogenesis GO:0045721 9.43 GCK INS
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 ICAM1 INS TNF
9 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.37 ICAM1 TNF
10 regulation of immunoglobulin secretion GO:0051023 9.32 CD40LG TNF
11 leukocyte cell-cell adhesion GO:0007159 9.13 CD40LG ICAM1 SELE
12 response to glucocorticoid GO:0051384 8.92 MDK MSTN OXT TNF

Molecular functions related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CD40LG IL16 MSTN TNF

Sources for Critical Illness Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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