MCID: CRT009
MIFTS: 40

Critical Illness Polyneuropathy malady

Categories: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

Aliases & Descriptions for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 12 14
Polyneuropathy, Critical Illness 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14402
ICD10 33 G62.81
ICD9CM 35 357.82
MeSH 42 D011115
SNOMED-CT 64 230594005
UMLS 69 C0393851

Summaries for Critical Illness Polyneuropathy

MalaCards based summary : Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to polyneuropathy and myopathy. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Type II diabetes mellitus. The drugs Zinc and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 71 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

Related Diseases for Critical Illness Polyneuropathy

Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Related Disease Score Top Affiliating Genes
1 polyneuropathy 10.7
2 myopathy 10.5
3 extratemporal epilepsy 10.3 INS POLB TNF
4 right ventricle hypoplasia 10.2 ICAM1 SELE TNF
5 tonsil cancer 10.2 CD40LG ICAM1 SELE
6 erb-duchenne and dejerine-klumpke palsies 10.2 ICAM1 SELE TNF
7 radial hypoplasia, triphalangeal thumbs and hypospadias 10.2 CD40LG SELE TNF
8 uveitis 10.1 CD40LG ICAM1 TNF
9 conduct disorder 10.1 CD40LG ICAM1 TNF
10 oral cavity cancer 10.1 CD40LG ICAM1 TNF
11 balkan nephropathy 10.1 ICAM1 SELE TNF
12 limb ischemia 10.1 ICAM1 INS TNF
13 parasitic protozoa infectious disease 10.1 ICAM1 SELE TNF
14 wound botulism 10.1 CD40LG TNF ZMYM2
15 migraine with aura 10.1 OXT SELE TNF
16 diabetic encephalopathy 10.1 ICAM1 INS TNF
17 xanthogranulomatous cholecystitis 10.1 CD40LG ICAM1 TNF
18 cervix small cell carcinoma 10.1 ICAM1 INS SELE TNF
19 spondylolysis 10.1 INS OXT TNF
20 calcinosis 10.1 CABIN1 CD40LG INS TNF
21 geniculate ganglionitis 10.1 ICAM1 SELE TNF
22 nonspecific interstitial pneumonia 10.1 CD40LG ICAM1 TNF
23 pyrimidine metabolic disorder 10.1 ICAM1 INS SELE TNF
24 dermatomycosis 10.1 CD40LG ICAM1 SELE TNF
25 powassan encephalitis 10.1 CD40LG ICAM1 SELE TNF
26 pemphigus vulgaris, familial 10.1 CD40LG ICAM1 SELE TNF
27 autoimmune-related retinopathy and optic neuropathy 10.0 ICAM1 INS SELE TNF
28 eating disorder 10.0 CD40LG ICAM1 SELE TNF
29 synovium cancer 10.0 ICAM1 SELE TNF
30 neuropathy 10.0
31 ovarian cystic teratoma 10.0 CD40LG MUC5AC TNF
32 avoidant personality disorder 10.0 INS OXT TNF
33 bare lymphocyte syndrome, type i 10.0 ICAM1 SELE TNF
34 nephropathy with pretibial epidermolysis bullosa and deafness 9.9 CD40LG MUC5AC TNF
35 encephalopathy 9.9
36 respiratory failure 9.9
37 acute chest syndrome 9.9 CD40LG ICAM1 MUC5AC TNF
38 microscopic breast papilloma 9.9 CD40LG ICAM1 TNF
39 dysphagia 9.8
40 acute motor-sensory axonal neuropathy 9.8
41 lymphoblastic leukemia 9.8
42 axonal neuropathy 9.8
43 leukemia 9.8
44 acute respiratory distress syndrome 9.8
45 myasthenia gravis 9.7
46 infective endocarditis 9.7
47 endocarditis 9.7
48 nephrotic syndrome 9.7
49 quadriplegia 9.7
50 beriberi 9.7

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to Critical Illness Polyneuropathy

Symptoms & Phenotypes for Critical Illness Polyneuropathy

MGI Mouse Phenotypes related to Critical Illness Polyneuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 CD40LG ICAM1 INS MDK MSTN SELE
2 homeostasis/metabolism MP:0005376 10.13 MDK MSTN MUC5AC OXT PNMT POLB
3 hematopoietic system MP:0005397 10.11 CABIN1 CD40LG GCK ICAM1 IL16 INS
4 immune system MP:0005387 10.03 CABIN1 CD40LG ICAM1 IL16 INS MDK
5 digestive/alimentary MP:0005381 9.95 ICAM1 INS MSTN MUC5AC OXT POLB
6 mortality/aging MP:0010768 9.83 GCK ICAM1 INS MDK MSTN OXT
7 liver/biliary system MP:0005370 9.7 GCK INS MDK MSTN POLB SELE
8 renal/urinary system MP:0005367 9.17 CD40LG GCK INS MDK MSTN OXT

Drugs & Therapeutics for Critical Illness Polyneuropathy

Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 3 7440-66-6 32051 23994
2
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
3
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
4
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
5
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
6
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
7 insulin Phase 3
8 Pharmaceutical Solutions Phase 3
9 Hypoglycemic Agents Phase 3
10 Insulin, Globin Zinc Phase 3
11 Testosterone undecanoate Phase 2, Phase 3
12 Testosterone 17 beta-cypionate Phase 2, Phase 3
13
Testosterone enanthate Phase 2, Phase 3 315-37-7 9416
14 Anabolic Agents Phase 2, Phase 3
15 Hormone Antagonists Phase 2, Phase 3
16 Androgens Phase 2, Phase 3
17 Hormones Phase 2, Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
19 Antineoplastic Agents, Hormonal Phase 2, Phase 3
20 Analgesics Phase 3
21 Adrenergic Agents Phase 3
22 Adrenergic Agonists Phase 3
23 Adrenergic alpha-2 Receptor Agonists Phase 3
24 Adrenergic alpha-Agonists Phase 3
25 Neurotransmitter Agents Phase 3
26 Analgesics, Non-Narcotic Phase 3
27 Peripheral Nervous System Agents Phase 3
28 Hypnotics and Sedatives Phase 3
29 Central Nervous System Depressants Phase 3
30 Immunoglobulins Phase 1
31 gamma-Globulins Phase 1
32 Immunoglobulins, Intravenous Phase 1
33 Rho(D) Immune Globulin Phase 1
34 Antibodies Phase 1
35 Anesthetics
36 Cola Nutraceutical

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
2 Tight Glycemic Control in Critical Care Patients Completed NCT00096421 Phase 3
3 Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) Completed NCT00135473 Phase 3
4 Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness Recruiting NCT03038919 Phase 2, Phase 3
5 Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness Assessment Recruiting NCT02706587 Phase 3
6 Dexmedetomidine for Continuous Sedation Terminated NCT00226785 Phase 3
7 Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M) Completed NCT00614562 Phase 1
8 The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis Terminated NCT01867645 Phase 1
9 Neurological Outcome in Surgical and Non-surgical Septic Patients Completed NCT02442986
10 New Onset Weakness in Critically Ill Patients and the Risk of Death and Recurrent ICU Admission Completed NCT00106665
11 Electrical Muscle Stimulation and Bicycling Combined to Early Standard Rehabilitation in the ICU Completed NCT02185989
12 Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit Recruiting NCT02763709
13 Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks. Recruiting NCT02706314
14 Neuromuscular Electrical Stimulation in the Critically Ill Recruiting NCT02566941
15 In-Bed Cycling in ICU Patients Post Cardiac Surgery Not yet recruiting NCT02976415

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

Anatomical Context for Critical Illness Polyneuropathy

MalaCards organs/tissues related to Critical Illness Polyneuropathy:

39
Testes, Heart, Liver

Publications for Critical Illness Polyneuropathy

Articles related to Critical Illness Polyneuropathy:

(show top 50) (show all 127)
id Title Authors Year
1
Recovery After Critical Illness Polyneuropathy in a Patient With Orthotopic Liver Transplantation: A Case Report. ( 27932182 )
2016
2
Critical illness polyneuropathy and myopathy 20A years later. No man's land? No, it is our land! ( 27502507 )
2016
3
Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. ( 27856098 )
2016
4
Acute Physiology and Chronic Health Evaluation II score of a8Y15: A risk factor for sepsis-induced critical illness polyneuropathy. ( 27381107 )
2016
5
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features. ( 27978832 )
2016
6
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability. ( 27207148 )
2016
7
Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy. ( 25916937 )
2015
8
Dysphagia diagnosed by fiberoptic endoscopy is common and transient in critical illness polyneuropathy: are there any clinical implications? ( 25599480 )
2015
9
Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness myopathy. ( 26311145 )
2015
10
513: CRITICAL ILLNESS POLYNEUROPATHY AND MYOPATHY IN THE PICU. ( 26570174 )
2015
11
Critical illness polyneuropathy and myopathy in a rural area in Vietnam. ( 26276515 )
2015
12
Bilateral Diaphragmatic Paralysis in a Patient With Critical Illness Polyneuropathy: A Case Report. ( 26252301 )
2015
13
Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. ( 24678152 )
2014
14
Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study. ( 25309729 )
2014
15
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. ( 24477672 )
2014
16
Dysphagia-A Common, Transient Symptom in Critical Illness Polyneuropathy: A Fiberoptic Endoscopic Evaluation of Swallowing Study. ( 25377021 )
2014
17
Intensive care unit-related generalized neuromuscular weakness due to critical illness polyneuropathy/myopathy in critically ill patients. ( 24981564 )
2014
18
Critical illness polyneuropathy and myopathy: a systematic review. ( 25206749 )
2014
19
A rare case of critical illness polyneuropathy and literature review. ( 24949002 )
2014
20
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. Response. ( 23667929 )
2013
21
"Dry" and "wet" beriberi mimicking critical illness polyneuropathy. ( 24339610 )
2013
22
Lower urinary tract dysfunction in critical illness polyneuropathy. ( 23949055 )
2013
23
Critical illness polyneuropathy and myopathy are common neuromuscular complications secondary to sepsis. ( 22307447 )
2013
24
Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy - a single center controlled observational study. ( 24176121 )
2013
25
Reversible tetraplegia after percutaneous nephrostolithotomy and septic shock: a case of critical illness polyneuropathy and myopathy with acute onset and complete recovery. ( 23409743 )
2013
26
Critical-illness-polyneuropathy as sequelae of severe neurological illness: incidence and impact on ventilator therapy and rehabilitation. ( 23422468 )
2013
27
Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. ( 23312812 )
2013
28
Is critical illness polyneuropathy associated with decreased heart rate variability? ( 24230479 )
2013
29
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. ( 23373568 )
2013
30
Strategies to prevent sepsis-induced intensive care unit-acquired weakness: are there any options? Commentary on "Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with surgically induced sepsis". ( 23295195 )
2013
31
Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial. ( 24088271 )
2013
32
Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. ( 23094903 )
2012
33
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review. ( 23158890 )
2012
34
Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia. ( 22246161 )
2012
35
Successful management of critical illness polyneuropathy and myopathy in renal transplant recipients. ( 22309422 )
2012
36
The critical illness polyneuropathy in septic patients with prolonged weaning from mechanical ventilation: is the diaphragm also affected? A pilot study. ( 22417531 )
2012
37
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. ( 21939902 )
2011
38
Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy? ( 22018206 )
2011
39
Rehabilitation of critical illness polyneuropathy and myopathy patients: an observational study. ( 22067549 )
2011
40
Critical illness polyneuropathy: a case report. ( 22142755 )
2011
41
Management of critical illness polyneuropathy and myopathy. ( 20816273 )
2010
42
Critical illness polyneuropathy in patients with major burn injuries. ( 21119768 )
2010
43
Critical illness polyneuropathy after septic peritonitis in a boy with nephrotic syndrome. ( 20232085 )
2010
44
Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology. ( 19760771 )
2010
45
Facial nerve involvement in critical illness polyneuropathy. ( 21189890 )
2010
46
Electrical muscle stimulation for prevention of critical illness polyneuropathy. ( 20624326 )
2010
47
The discovery of critical illness polyneuropathy: a memoir. ( 20724249 )
2010
48
Critical illness polyneuropathy and myopathy in the intensive care unit. ( 19578344 )
2009
49
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. ( 19160304 )
2009
50
Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course. ( 19388901 )
2009

Variations for Critical Illness Polyneuropathy

Expression for Critical Illness Polyneuropathy

Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for Critical Illness Polyneuropathy

GO Terms for Critical Illness Polyneuropathy

Cellular components related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 CD40LG ICAM1 IL16 INS MSTN MUC5AC
2 voltage-gated sodium channel complex GO:0001518 8.96 SCN4A SCN5A

Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 glucose metabolic process GO:0006006 9.58 GCK INS TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.56 CD40LG ICAM1 INS TNF
3 negative regulation of lipid catabolic process GO:0050995 9.51 INS TNF
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 ICAM1 INS TNF
5 regulation of protein secretion GO:0050708 9.49 INS TNF
6 positive regulation of glycogen biosynthetic process GO:0045725 9.48 GCK INS
7 leukocyte tethering or rolling GO:0050901 9.46 SELE TNF
8 negative regulation of gluconeogenesis GO:0045721 9.43 GCK INS
9 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
10 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.16 ICAM1 TNF
11 leukocyte cell-cell adhesion GO:0007159 9.13 CD40LG ICAM1 SELE
12 response to glucocorticoid GO:0051384 8.92 MDK MSTN OXT TNF

Molecular functions related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CD40LG IL16 MSTN TNF

Sources for Critical Illness Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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