MCID: CRT009
MIFTS: 39

Critical Illness Polyneuropathy malady

Category: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

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Aliases & Descriptions for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 11 13
 
Polyneuropathy, Critical Illness 68

Classifications:



External Ids:

Disease Ontology11 DOID:14402
ICD1030 G62.81
SNOMED-CT62 230594005
ICD9CM32 357.82
MeSH39 D011115

Summaries for Critical Illness Polyneuropathy

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Wikipedia:71 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

MalaCards based summary: Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to polyneuropathy and hemangioma of intra-abdominal structure. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways are LDL Oxidation in Atherogenesis and Type II diabetes mellitus. Affiliated tissues include testes, colon and heart, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Related Diseases for Critical Illness Polyneuropathy

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Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy10.7
2hemangioma of intra-abdominal structure10.5INS, TNF
3myopathy10.5
4gamma heavy chain disease10.4CD40LG, PNMT
5toxic megacolon10.4GCK, INS
6ornithosis10.4CD40LG, CS
7craniosynostosis10.3INS, SCN5A, TNF
8lymphomatoid papulosis10.3ICAM1, SELE
9indian tick typhus10.3CD40LG, SELE
10marginal corneal ulcer10.3ICAM1, SELE
11short bowel syndrome10.3GCK, INS, TNF
12neonatal diabetes mellitus10.3GCK, INS, TNF
13peripheral scars of retina10.3ICAM1, SELE
14femoral neuropathy10.3GCK, INS, TNF
15casr-related disorders10.3INS, SELE
16survival motor neuron spinal muscular atrophy10.3GCK, INS, TNF
17cartilage disease10.3INS, TNF
18hypertrichosis10.2GCK, INS, TNF
19foodborne botulism10.2CD40LG, TNF, ZMYM2
20perianal skin paget's disease10.2CD40LG, INS, TNF
21diabetic encephalopathy10.2ICAM1, INS, TNF
22night blindness10.2CD40LG, TNF
23leukostasis10.2CD40LG, SELE, TNF
24periampullary adenoma10.2ICAM1, INS, TNF
25rhizomelic pseudopolyarthritis10.2ICAM1, SELE, TNF
26spastic paraplegia-paget disease of bone syndrome10.2ICAM1, SELE, TNF
27emphysema, congenital lobar10.2CD40LG, SELE, TNF
28dementia - subcortical10.2ICAM1, SELE, TNF
29wissler's syndrome10.2ICAM1, SELE, TNF
30brucella abortus brucellosis10.1CD40LG, TNF
31lung sarcoma10.1ICAM1, SELE, TNF
32iron metabolism disease10.1ICAM1, INS, SELE
33parasitic helminthiasis infectious disease10.1CD40LG, ICAM1, SELE
34spotted fever10.1CD40LG, CS
35chromoblastomycosis10.1CD40LG, ICAM1, SELE
36streptococcal meningitis10.1MUC5AC, TNF
37lateral sclerosis10.1INS, OXT, TNF
38chronic intestinal vascular insufficiency10.1CD40LG, INS, TNF
39malignant histiocytosis10.1CD40LG, ICAM1, TNF
40dentin dysplasia10.1CD40LG, ICAM1, TNF
41candidiasis10.1INS, OXT, TNF
42biliary tract disease10.1CD40LG, ICAM1, TNF
43idiopathic interstitial pneumonia10.0CD40LG, ICAM1, TNF
44neuropathy10.0
45sacral spinal canal and spinal cord meningioma10.0CD40LG, ICAM1, TNF
46adrenal rest tumor10.0CD40LG, INS, SELE, TNF
47inner ear cancer10.0CD40LG, MUC5AC, TNF
48myelitis10.0CD40LG, ICAM1, TNF
49littre gland carcinoma10.0ICAM1, INS, SELE, TNF
50basaloid squamous cell carcinoma10.0CD40LG, ICAM1, TNF

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to critical illness polyneuropathy

Symptoms & Phenotypes for Critical Illness Polyneuropathy

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MGI Mouse Phenotypes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7ICAM1, INS, MSTN, MUC5AC, OXT, POLB
2MP:00053858.2CD40LG, ICAM1, INS, MSTN, OXT, PNMT
3MP:00053767.1CD40LG, GCK, ICAM1, INS, MSTN, MUC5AC
4MP:00107686.0CABIN1, CD40LG, CS, GCK, ICAM1, INS

Drugs & Therapeutics for Critical Illness Polyneuropathy

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Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ZincapprovedPhase 322317440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
2
Midazolamapproved, illicitPhase 368459467-70-84192
Synonyms:
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
59467-70-8
8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride
8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
AC-18749
AC1L1HMA
BIDD:GT0647
BRN 0625572
Buccolam
C07524
C18H13ClFN3
CHEMBL655
CID4192
D00550
DB00683
DEA No. 2884
Dazolam
Dea No. 2884
 
Dormicum
Dormicum (TN)
EINECS 261-774-5
LS-77780
Midanium
Midazolam
Midazolam (JAN/INN)
Midazolam Base
Midazolam Hcl
Midazolam [INN:BAN:JAN]
Midazolamum
Midazolamum [INN-Latin]
Midosed
MolPort-003-849-219
NCGC00168254-01
Ro 21-3981
TL8003787
UC429_SIGMA
UNII-R60L0SM5BC
Versed
ZINC00001732
midazolam
nchembio747-comp32
3
Dexmedetomidineapproved, vet_approvedPhase 354076631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
4
Propofolapproved, investigational, vet_approvedPhase 310282078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
5Hypoglycemic AgentsPhase 35733
6Pharmaceutical SolutionsPhase 37793
7Insulin, Globin ZincPhase 34523
8insulinPhase 34524
9Hypnotics and SedativesPhase 32485
10Neurotransmitter AgentsPhase 317734
11Peripheral Nervous System AgentsPhase 322776
12Central Nervous System DepressantsPhase 312806
13Adrenergic AgonistsPhase 32877
14Analgesics, Non-NarcoticPhase 36260
15Adrenergic alpha-2 Receptor AgonistsPhase 3911
16Adrenergic AgentsPhase 35140
17Adrenergic alpha-AgonistsPhase 31625
18AnalgesicsPhase 311287
19Immunoglobulins, IntravenousPhase 1324
20Rho(D) Immune GlobulinPhase 1317
21gamma-GlobulinsPhase 1317
22ImmunoglobulinsPhase 16045
23AntibodiesPhase 16045
24ColaNutraceutical1881

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.Unknown statusNCT02033057Phase 4
2Tight Glycemic Control in Critical Care PatientsCompletedNCT00096421Phase 3
3Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)CompletedNCT00135473Phase 3
4Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness AssessmentRecruitingNCT02706587Phase 3
5Dexmedetomidine for Continuous SedationTerminatedNCT00226785Phase 3
6Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M)CompletedNCT00614562Phase 1
7The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/SepsisTerminatedNCT01867645Phase 1
8New Onset Weakness in Critically Ill Patients and the Risk of Death and Recurrent ICU AdmissionCompletedNCT00106665
9Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care UnitRecruitingNCT02763709
10Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.RecruitingNCT02706314
11Neuromuscular Electrical Stimulation in the Critically IllRecruitingNCT02566941
12Neurological Outcome in Surgical and Non-surgical Septic PatientsRecruitingNCT02442986
13Electrical Muscle Stimulation and Bicycling Combined to Early Standard Rehabilitation in the ICURecruitingNCT02185989
14In-Bed Cycling in ICU Patients Post Cardiac SurgeryNot yet recruitingNCT02976415

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

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Anatomical Context for Critical Illness Polyneuropathy

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MalaCards organs/tissues related to Critical Illness Polyneuropathy:

36
Testes, Colon, Heart, Liver

Publications for Critical Illness Polyneuropathy

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Articles related to Critical Illness Polyneuropathy:

(show top 50)    (show all 127)
idTitleAuthorsYear
1
Recovery After Critical Illness Polyneuropathy in a Patient With Orthotopic Liver Transplantation: A Case Report. (27932182)
2016
2
Critical illness polyneuropathy and myopathy 20A years later. No man's land? No, it is our land! (27502507)
2016
3
Acute Physiology and Chronic Health Evaluation II score of a8Y15: A risk factor for sepsis-induced critical illness polyneuropathy. (27381107)
2016
4
Critical illness polyneuropathy (CIP) in neurological early rehabilitation: clinical and neurophysiological features. (27978832)
2016
5
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability. (27207148)
2016
6
Gastric perforation and critical illness polyneuropathy after steroid treatment in a patient with encephalitis/encephalopathy with transient splenial lesion. (27856098)
2016
7
Bilateral Diaphragmatic Paralysis in a Patient With Critical Illness Polyneuropathy: A Case Report. (26252301)
2015
8
Critical illness polyneuropathy and myopathy in a rural area in Vietnam. (26276515)
2015
9
Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness myopathy. (26311145)
2015
10
Dysphagia diagnosed by fiberoptic endoscopy is common and transient in critical illness polyneuropathy: are there any clinical implications? (25599480)
2015
11
513: CRITICAL ILLNESS POLYNEUROPATHY AND MYOPATHY IN THE PICU. (26570174)
2015
12
Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy. (25916937)
2015
13
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. (24477672)
2014
14
Dysphagia-A Common, Transient Symptom in Critical Illness Polyneuropathy: A Fiberoptic Endoscopic Evaluation of Swallowing Study. (25377021)
2014
15
A rare case of critical illness polyneuropathy and literature review. (24949002)
2014
16
Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. (24678152)
2014
17
Intensive care unit-related generalized neuromuscular weakness due to critical illness polyneuropathy/myopathy in critically ill patients. (24981564)
2014
18
Critical illness polyneuropathy and myopathy: a systematic review. (25206749)
2014
19
Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study. (25309729)
2014
20
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. Response. (23667929)
2013
21
Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy - a single center controlled observational study. (24176121)
2013
22
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. (23373568)
2013
23
Reversible tetraplegia after percutaneous nephrostolithotomy and septic shock: a case of critical illness polyneuropathy and myopathy with acute onset and complete recovery. (23409743)
2013
24
Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial. (24088271)
2013
25
Critical illness polyneuropathy and myopathy are common neuromuscular complications secondary to sepsis. (22307447)
2013
26
Dry" and "wet" beriberi mimicking critical illness polyneuropathy. (24339610)
2013
27
Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. (23312812)
2013
28
Is critical illness polyneuropathy associated with decreased heart rate variability? (24230479)
2013
29
Lower urinary tract dysfunction in critical illness polyneuropathy. (23949055)
2013
30
Critical-illness-polyneuropathy as sequelae of severe neurological illness: incidence and impact on ventilator therapy and rehabilitation. (23422468)
2013
31
Strategies to prevent sepsis-induced intensive care unit-acquired weakness: are there any options? Commentary on "Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with surgically induced sepsis". (23295195)
2013
32
Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. (23094903)
2012
33
Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia. (22246161)
2012
34
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review. (23158890)
2012
35
Successful management of critical illness polyneuropathy and myopathy in renal transplant recipients. (22309422)
2012
36
The critical illness polyneuropathy in septic patients with prolonged weaning from mechanical ventilation: is the diaphragm also affected? A pilot study. (22417531)
2012
37
Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy? (22018206)
2011
38
Critical illness polyneuropathy: a case report. (22142755)
2011
39
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. (21939902)
2011
40
Rehabilitation of critical illness polyneuropathy and myopathy patients: an observational study. (22067549)
2011
41
Management of critical illness polyneuropathy and myopathy. (20816273)
2010
42
Electrical muscle stimulation for prevention of critical illness polyneuropathy. (20624326)
2010
43
Critical illness polyneuropathy after septic peritonitis in a boy with nephrotic syndrome. (20232085)
2010
44
Facial nerve involvement in critical illness polyneuropathy. (21189890)
2010
45
Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology. (19760771)
2010
46
Critical illness polyneuropathy in patients with major burn injuries. (21119768)
2010
47
The discovery of critical illness polyneuropathy: a memoir. (20724249)
2010
48
Critical illness polyneuropathy and myopathy in the intensive care unit. (19578344)
2009
49
Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course. (19388901)
2009
50
Critical illness polyneuropathy after Bacillus cereus sepsis in acute lymphoblastic leukemia. (19571454)
2009

Variations for Critical Illness Polyneuropathy

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Expression for genes affiliated with Critical Illness Polyneuropathy

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Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for genes affiliated with Critical Illness Polyneuropathy

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GO Terms for genes affiliated with Critical Illness Polyneuropathy

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Cellular components related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:000151810.0SCN4A, SCN5A
2extracellular spaceGO:00056157.6CD40LG, ICAM1, INS, MSTN, MUC5AC, OXT

Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid catabolic processGO:005099510.6INS, TNF
2negative regulation of gluconeogenesisGO:004572110.5GCK, INS
3positive regulation of glycogen biosynthetic processGO:004572510.5GCK, INS
4positive regulation of glycolytic processGO:004582110.5GCK, INS
5leukocyte tethering or rollingGO:005090110.5SELE, TNF
6regulation of protein secretionGO:005070810.4INS, TNF
7regulation of immunoglobulin secretionGO:005102310.3CD40LG, TNF
8glucose metabolic processGO:000600610.2GCK, INS, TNF
9positive regulation of nitric oxide biosynthetic processGO:004542910.0ICAM1, INS, TNF
10leukocyte cell-cell adhesionGO:00071599.9CD40LG, ICAM1, SELE
11positive regulation of NF-kappaB transcription factor activityGO:00510929.6CD40LG, ICAM1, INS, TNF
12response to glucocorticoidGO:00513849.2MSTN, OXT, TNF

Molecular functions related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:000524810.0SCN4A, SCN5A

Sources for Critical Illness Polyneuropathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet