MCID: CRT009
MIFTS: 39

Critical Illness Polyneuropathy malady

Category: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

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Aliases & Descriptions for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 10 12
 
Polyneuropathy, Critical Illness 65

Classifications:



External Ids:

Disease Ontology10 DOID:14402
ICD1027 G62.81
SNOMED-CT59 230594005
ICD9CM29 357.82
MeSH36 D011115
UMLS65 C0393851

Summaries for Critical Illness Polyneuropathy

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Wikipedia:68 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

MalaCards based summary: Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to polyneuropathy and landau-kleffner syndrome. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways are Interaction between L1 and Ankyrins and Cell adhesion molecules (CAMs). Affiliated tissues include testes, b cells and colon, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Related Diseases for Critical Illness Polyneuropathy

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Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy10.8
2landau-kleffner syndrome10.7PNMT, POLB
3aneruptive fever10.6CD40LG, CS
4rickettsialpox10.6CD40LG, CS
5rabies10.6CD40LG, CS
6alpha chain disease10.6CD40LG, PNMT
7myopathy10.6
8colon carcinoma in situ10.5ICAM1, SELE
9mu chain disease10.5CD40LG, PNMT
10solar retinopathy10.5ICAM1, SELE
11rhizomelic dysplasia patterson lowry type10.5ICAM1, SELE
12diphyllobothriasis10.5ICAM1, SELE
13inferior myocardial infarction10.5ICAM1, SELE
14thrombocytopenia10.5ICAM1, SELE
15conduct disorder10.4ICAM1, SELE
16pemphigus10.4CD40LG, ICAM1
17intra-abdominal lymph node mast cell malignancy10.4ICAM1, SELE
18angioedema10.4CD40LG, ICAM1
19congenital diaphragmatic hernia10.4ICAM1, SELE
20crescentic glomerulonephritis10.4CD40LG, ICAM1
21opportunistic bacterial infectious disease10.3CD40LG, ZMYM2
22qualitative platelet defect10.3CD40LG, ICAM1
23liver cirrhosis10.3ICAM1, MUC5AC
24thumb absent short stature immune deficiency10.3CABIN1, SELE
25perineocele10.3CD40LG, OXT
26soft palate cancer10.2CD40LG, ICAM1
27neuroaxonal dystrophy10.2CD40LG, ZMYM2
28astrakhan spotted fever10.2CD40LG, SELE
29hodgkin's granuloma10.2CD40LG, ICAM1, SELE
30auricular cancer10.2CD40LG, MUC5AC
31mitochondrial metabolism disease10.1CD40LG, ICAM1, SELE
32neuropathy10.1
33duodenum cancer10.1OXT, SELE
34vagus nerve neoplasm10.1CD40LG, SELE
35capillary hemangioma10.1CD40LG, ICAM1, SELE
36respiratory failure10.0
37diffuse scleroderma10.0CD40LG, ICAM1, MUC5AC
38leukemia9.9
39lymphoblastic leukemia9.9
40axonal neuropathy9.9
41acute respiratory distress syndrome9.9
42dysphagia9.9
43encephalopathy9.9
44acute motor-sensory axonal neuropathy9.9
45dengue hemorrhagic fever9.8CD40LG, ICAM1
46burns9.8
47myasthenia gravis9.8
48infective endocarditis9.8
49endocarditis9.8
50nephrotic syndrome9.8

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to critical illness polyneuropathy

Symptoms for Critical Illness Polyneuropathy

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Drugs & Therapeutics for Critical Illness Polyneuropathy

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Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Propofolapproved, investigationalPhase 39312078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
2
Midazolamapproved, illicitPhase 363559467-70-84192
Synonyms:
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
59467-70-8
8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride
8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
AC-18749
AC1L1HMA
BIDD:GT0647
BRN 0625572
Buccolam
C07524
C18H13ClFN3
CHEMBL655
CID4192
D00550
DB00683
DEA No. 2884
Dazolam
Dea No. 2884
Dormicum
 
Dormicum (TN)
EINECS 261-774-5
LS-77780
Midanium
Midazolam
Midazolam (JAN/INN)
Midazolam Base
Midazolam Hcl
Midazolam Hydrochloride
Midazolam [INN:BAN:JAN]
Midazolamum
Midazolamum [INN-Latin]
Midosed
MolPort-003-849-219
NCGC00168254-01
Ro 21-3981
TL8003787
UC429_SIGMA
UNII-R60L0SM5BC
Versed
ZINC00001732
midazolam
nchembio747-comp32
3
DexmedetomidineapprovedPhase 3470113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
Dexdor (T)
 
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidine Hydrochloride
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex
Precedex (TN)
Tocris-2023
ZINC04632106
4Pharmaceutical SolutionsPhase 37004
5insulinPhase 34278
6Insulin, Globin ZincPhase 34278
7Hypoglycemic AgentsPhase 34503
8Neurotransmitter AgentsPhase 314795
9Peripheral Nervous System AgentsPhase 318510
10Central Nervous System DepressantsPhase 310016
11Hypnotics and SedativesPhase 32032
12Adrenergic AgonistsPhase 32331
13Analgesics, Non-NarcoticPhase 35184
14Adrenergic alpha-2 Receptor AgonistsPhase 3790
15Adrenergic AgentsPhase 34204
16Adrenergic alpha-AgonistsPhase 31300
17AnalgesicsPhase 39358
18Immunologic FactorsPhase 118483
19Rho(D) Immune GlobulinPhase 1206
20ImmunoglobulinsPhase 14477
21Immunoglobulins, IntravenousPhase 1211
22AntibodiesPhase 14477
23ColaNutraceutical1768

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.RecruitingNCT02033057Phase 4
2Tight Glycemic Control in Critical Care PatientsCompletedNCT00096421Phase 3
3Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)CompletedNCT00135473Phase 3
4Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness AssessmentNot yet recruitingNCT02706587Phase 3
5Dexmedetomidine for Continuous SedationTerminatedNCT00226785Phase 3
6Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M)CompletedNCT00614562Phase 1
7The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/SepsisTerminatedNCT01867645Phase 1
8New Onset Weakness in Critically Ill Patients and the Risk of Death and Recurrent ICU AdmissionCompletedNCT00106665
9Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care UnitRecruitingNCT02763709
10Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.RecruitingNCT02706314
11Neurological Outcome in Surgical and Non-surgical Septic PatientsRecruitingNCT02442986
12Electrical Muscle Stimulation and Bicycling Combined to Early Standard Rehabilitation in the ICURecruitingNCT02185989
13Neuromuscular Electrical Stimulation in the Critically IllNot yet recruitingNCT02566941

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

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Anatomical Context for Critical Illness Polyneuropathy

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MalaCards organs/tissues related to Critical Illness Polyneuropathy:

33
Testes, B cells, Colon, Lung, Thyroid, Endothelial, Breast

Animal Models for Critical Illness Polyneuropathy or affiliated genes

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MGI Mouse Phenotypes related to Critical Illness Polyneuropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.5CD40LG, GCK, ICAM1, IGFBP3, KIAA0101, OXT
2MP:00107686.8CABIN1, CD40LG, CS, GCK, ICAM1, OXT
3MP:00053766.4CD40LG, GCK, ICAM1, IGFBP3, MUC5AC, OXT

Publications for Critical Illness Polyneuropathy

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Articles related to Critical Illness Polyneuropathy:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability. (27207148)
2016
2
Bilateral Diaphragmatic Paralysis in a Patient With Critical Illness Polyneuropathy: A Case Report. (26252301)
2015
3
Critical illness polyneuropathy and myopathy in a rural area in Vietnam. (26276515)
2015
4
Dysphagia diagnosed by fiberoptic endoscopy is common and transient in critical illness polyneuropathy: are there any clinical implications? (25599480)
2015
5
Optimizing testing methods and collection of reference data for differentiating critical illness polyneuropathy from critical illness myopathy. (26311145)
2015
6
513: CRITICAL ILLNESS POLYNEUROPATHY AND MYOPATHY IN THE PICU. (26570174)
2015
7
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. (24477672)
2014
8
Dysphagia-A Common, Transient Symptom in Critical Illness Polyneuropathy: A Fiberoptic Endoscopic Evaluation of Swallowing Study. (25377021)
2014
9
Critical illness polyneuropathy and myopathy: a systematic review. (25206749)
2014
10
Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study. (25309729)
2014
11
A rare case of critical illness polyneuropathy and literature review. (24949002)
2014
12
Critical illness polyneuropathy/critical illness myopathy and acute motor-sensory axonal neuropathy. Response. (23667929)
2013
13
Is critical illness polyneuropathy associated with decreased heart rate variability? (24230479)
2013
14
Euglycemic state reduces the incidence of critical illness polyneuropathy and duration of ventilator dependency in medical intensive care unit. (23094903)
2012
15
Successful management of critical illness polyneuropathy and myopathy in renal transplant recipients. (22309422)
2012
16
Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia. (22246161)
2012
17
Treatment of critical illness polyneuropathy and/or myopathy - a systematic review. (23158890)
2012
18
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. (21939902)
2011
19
Is plasma calcium concentration implicated in the development of critical illness polyneuropathy and myopathy? (22018206)
2011
20
Management of critical illness polyneuropathy and myopathy. (20816273)
2010
21
Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology. (19760771)
2010
22
Critical illness polyneuropathy and myopathy in the intensive care unit. (19578344)
2009
23
Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course. (19388901)
2009
24
Critical illness polyneuropathy after Bacillus cereus sepsis in acute lymphoblastic leukemia. (19571454)
2009
25
Interventions for preventing critical illness polyneuropathy and critical illness myopathy. (19160304)
2009
26
Clinical review: Critical illness polyneuropathy and myopathy. (19040777)
2008
27
Role of endotoxin in the pathogenesis of critical illness polyneuropathy. (18283402)
2008
28
Critical illness polyneuropathy. Regression following cardiac operation. (17669887)
2007
29
Diagnosis and management of critical illness polyneuropathy and critical illness myopathy. (17298769)
2007
30
Nerve excitability changes in critical illness polyneuropathy. (16901913)
2006
31
Weakness in the ICU: Guillain-BarrAc syndrome, myasthenia gravis, and critical illness polyneuropathy/myopathy. (16286877)
2005
32
Rehabilitation of a patient with critical illness polyneuropathy (CIP) following acute respiratory failure: a case report and review of literature. (12623617)
2003
33
Critical illness polyneuropathy. (12386490)
2002
34
Clinical outcomes of critical illness polyneuropathy. (11898892)
2002
35
Critical illness polyneuropathy: clinical findings and cell culture assay of neurotoxicity assessed by a prospective study. (11398694)
2001
36
Vecuronium-associated axonal motor neuropathy: a variant of critical illness polyneuropathy? (11525888)
2001
37
Distinctions between critical illness polyneuropathy and axonal Guillain-BarrAc syndrome. (10787316)
2000
38
Incidence and onset of critical illness polyneuropathy in patients with septic shock. (10821976)
2000
39
Long-term outcome of critical illness polyneuropathy. (11135284)
2000
40
Relation between critical illness polyneuropathy and axonal Guillain-BarrAc syndrome. (10454879)
1999
41
Possible role of dietary lipids in critical illness polyneuropathy. (9503229)
1998
42
Critical illness polyneuropathy due to parenteral nutrition. (9310819)
1997
43
Critical illness polyneuropathy--only due to parenteral nutrition? (9310818)
1997
44
Predominant involvement of motor fibres in patients with critical illness polyneuropathy. (9389283)
1997
45
Critical illness polyneuropathy: clinical findings and outcomes of a frequent cause of neuromuscular weaning failure. (8706487)
1996
46
Critical illness polyneuropathy, facts and controversies. (10970117)
1996
47
Critical-illness polyneuropathy complicating cardiac operation. (8607690)
1996
48
The expanding spectrum of critical illness polyneuropathy. (8706479)
1996
49
Are autoimmune mechanisms involved in critical illness polyneuropathy? (7560486)
1995
50
Critical illness polyneuropathy. A complication of sepsis and multiple organ failure. (3651796)
1987

Variations for Critical Illness Polyneuropathy

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Expression for genes affiliated with Critical Illness Polyneuropathy

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Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for genes affiliated with Critical Illness Polyneuropathy

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Pathways related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
110.0SCN4A, SCN5A
29.4CD40LG, ICAM1, SELE
39.4CD40LG, ICAM1, SELE

GO Terms for genes affiliated with Critical Illness Polyneuropathy

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Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:00071599.9CD40LG, ICAM1
2regulation of postsynaptic membrane potentialGO:00600789.9SCN4A, SCN5A
3heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:00071579.8ICAM1, SELE

Sources for Critical Illness Polyneuropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet