MCID: CRT009
MIFTS: 33

Critical Illness Polyneuropathy malady

Category: Neuronal diseases

Aliases & Classifications for Critical Illness Polyneuropathy

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Aliases & Descriptions for Critical Illness Polyneuropathy:

Name: Critical Illness Polyneuropathy 10 12
 
Polyneuropathy, Critical Illness 65

Classifications:



External Ids:

Disease Ontology10 DOID:14402
ICD1027 G62.81
SNOMED-CT59 230594005
ICD9CM29 357.82
MeSH36 D011115
UMLS65 C0393851

Summaries for Critical Illness Polyneuropathy

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Wikipedia:68 Critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are overlapping syndromes of... more...

MalaCards based summary: Critical Illness Polyneuropathy, also known as polyneuropathy, critical illness, is related to thrombocytopenia and crescentic glomerulonephritis. An important gene associated with Critical Illness Polyneuropathy is CS (Citrate Synthase), and among its related pathways are Interaction between L1 and Ankyrins and Cell adhesion molecules (CAMs). Affiliated tissues include testes, colon and endothelial, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Related Diseases for Critical Illness Polyneuropathy

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Diseases related to Critical Illness Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia30.7ICAM1, SELE
2crescentic glomerulonephritis30.4CD40LG, ICAM1
3landau-kleffner syndrome10.5PNMT, POLB
4aneruptive fever10.4CD40LG, CS
5rickettsialpox10.4CD40LG, CS
6rabies10.4CD40LG, CS
7alpha chain disease10.4CD40LG, PNMT
8colon carcinoma in situ10.3ICAM1, SELE
9mu chain disease10.3CD40LG, PNMT
10solar retinopathy10.3ICAM1, SELE
11rhizomelic dysplasia patterson lowry type10.3ICAM1, SELE
12diphyllobothriasis10.3ICAM1, SELE
13inferior myocardial infarction10.3ICAM1, SELE
14conduct disorder10.3ICAM1, SELE
15lymphoma10.3
16endotheliitis10.3
17pemphigus10.3CD40LG, ICAM1
18intra-abdominal lymph node mast cell malignancy10.3ICAM1, SELE
19angioedema10.2CD40LG, ICAM1
20congenital diaphragmatic hernia10.2ICAM1, SELE
21opportunistic bacterial infectious disease10.2CD40LG, ZMYM2
22qualitative platelet defect10.2CD40LG, ICAM1
23lung cancer10.2
24goiter10.2
25ovarian cancer10.2
26ischemia10.2
27liver cirrhosis10.2ICAM1, MUC5AC
28thumb absent short stature immune deficiency10.2CABIN1, SELE
29perineocele10.2CD40LG, OXT
30soft palate cancer10.2CD40LG, ICAM1
31neuroaxonal dystrophy10.1CD40LG, ZMYM2
32astrakhan spotted fever10.1CD40LG, SELE
33hodgkin's granuloma10.1CD40LG, ICAM1, SELE
34auricular cancer10.1CD40LG, MUC5AC
35mitochondrial metabolism disease10.1CD40LG, ICAM1, SELE
36duodenum cancer10.1OXT, SELE
37vagus nerve neoplasm10.1CD40LG, SELE
38capillary hemangioma10.1CD40LG, ICAM1, SELE
39hiv-110.0
40cystinuria10.0
41breast cancer10.0
42obesity10.0
43aplastic anemia10.0
44achondroplasia10.0
45leprosy10.0
46adenomatous polyposis coli10.0
47osteoporosis10.0
48melkersson-rosenthal syndrome10.0
49peutz-jeghers syndrome10.0
50panic disorder10.0

Graphical network of the top 20 diseases related to Critical Illness Polyneuropathy:



Diseases related to critical illness polyneuropathy

Symptoms for Critical Illness Polyneuropathy

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Drugs & Therapeutics for Critical Illness Polyneuropathy

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Drugs for Critical Illness Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Propofolapproved, investigationalPhase 39312078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
2
Midazolamapproved, illicitPhase 363559467-70-84192
Synonyms:
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
59467-70-8
8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride
8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
AC-18749
AC1L1HMA
BIDD:GT0647
BRN 0625572
Buccolam
C07524
C18H13ClFN3
CHEMBL655
CID4192
D00550
DB00683
DEA No. 2884
Dazolam
Dea No. 2884
Dormicum
 
Dormicum (TN)
EINECS 261-774-5
LS-77780
Midanium
Midazolam
Midazolam (JAN/INN)
Midazolam Base
Midazolam Hcl
Midazolam Hydrochloride
Midazolam [INN:BAN:JAN]
Midazolamum
Midazolamum [INN-Latin]
Midosed
MolPort-003-849-219
NCGC00168254-01
Ro 21-3981
TL8003787
UC429_SIGMA
UNII-R60L0SM5BC
Versed
ZINC00001732
midazolam
nchembio747-comp32
3
DexmedetomidineapprovedPhase 3470113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
Dexdor (T)
 
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidine Hydrochloride
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex
Precedex (TN)
Tocris-2023
ZINC04632106
4Pharmaceutical SolutionsPhase 37004
5insulinPhase 34278
6Insulin, Globin ZincPhase 34278
7Hypoglycemic AgentsPhase 34503
8Neurotransmitter AgentsPhase 314795
9Peripheral Nervous System AgentsPhase 318510
10Central Nervous System DepressantsPhase 310016
11Hypnotics and SedativesPhase 32032
12Adrenergic AgonistsPhase 32331
13Analgesics, Non-NarcoticPhase 35184
14Adrenergic alpha-2 Receptor AgonistsPhase 3790
15Adrenergic AgentsPhase 34204
16Adrenergic alpha-AgonistsPhase 31300
17AnalgesicsPhase 39358
18Immunologic FactorsPhase 118483
19Rho(D) Immune GlobulinPhase 1206
20ImmunoglobulinsPhase 14477
21Immunoglobulins, IntravenousPhase 1211
22AntibodiesPhase 14477
23ColaNutraceutical1768

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.RecruitingNCT02033057Phase 4
2Tight Glycemic Control in Critical Care PatientsCompletedNCT00096421Phase 3
3Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)CompletedNCT00135473Phase 3
4Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness AssessmentNot yet recruitingNCT02706587Phase 3
5Dexmedetomidine for Continuous SedationTerminatedNCT00226785Phase 3
6Neurally Adjusted Ventilatory Assist (NAVA) in Patients With Critical Illness Associated Polyneuropathy / or Polymyopathy (CIP/M)CompletedNCT00614562Phase 1
7The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/SepsisTerminatedNCT01867645Phase 1
8New Onset Weakness in Critically Ill Patients and the Risk of Death and Recurrent ICU AdmissionCompletedNCT00106665
9Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care UnitRecruitingNCT02763709
10Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.RecruitingNCT02706314
11Neurological Outcome in Surgical and Non-surgical Septic PatientsRecruitingNCT02442986
12Electrical Muscle Stimulation and Bicycling Combined to Early Standard Rehabilitation in the ICURecruitingNCT02185989
13Neuromuscular Electrical Stimulation in the Critically IllNot yet recruitingNCT02566941

Search NIH Clinical Center for Critical Illness Polyneuropathy

Genetic Tests for Critical Illness Polyneuropathy

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Anatomical Context for Critical Illness Polyneuropathy

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MalaCards organs/tissues related to Critical Illness Polyneuropathy:

33
Testes, Colon, Endothelial, Breast, Brain, B cells, Lung

Animal Models for Critical Illness Polyneuropathy or affiliated genes

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MGI Mouse Phenotypes related to Critical Illness Polyneuropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.5CD40LG, GCK, ICAM1, IGFBP3, KIAA0101, OXT
2MP:00107686.8CABIN1, CD40LG, CS, GCK, ICAM1, OXT
3MP:00053766.4CD40LG, GCK, ICAM1, IGFBP3, MUC5AC, OXT

Publications for Critical Illness Polyneuropathy

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Articles related to Critical Illness Polyneuropathy:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan. (25891007)
2015
2
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. (25272296)
2014
3
Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population. (24947733)
2014
4
Effects of CT-Xp gene knock down in melanoma cell lines. (23625514)
2013
5
A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children. (22048715)
2012
6
Update: A 52-year-old woman with disabling peripheral neuropathy. (22215168)
2012
7
CBDCA + Pemetrexed + Bevacizumab and Its Maintenance Chemotherapy in a Case of Solitary Breast Metastasis from a Lung Adenocarcinoma Resistant to Gefitinib. (23139670)
2012
8
A revised scoring system for cutaneous lupus erythematosus: the RCLASI. (20645979)
2010
9
High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer. (20132214)
2010
10
Raloxifene inhibits tumor growth and lymph node metastasis in a xenograft model of metastatic mammary cancer. (20958960)
2010
11
Desmoglein-2 and desmocollin-2 mutations in dutch arrhythmogenic right ventricular dysplasia/cardiomypathy patients: results from a multicenter study. (20031616)
2009
12
Industasis, a promotion of tumor formation by nontumorigenic stray cells. (19487282)
2009
13
Synthesis and biological activities of 14-epi-MART-10 and 14-epi-MART-11: implications for cancer and osteoporosis treatment. (19667149)
2009
14
The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP. (18556415)
2008
15
Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis. (18239465)
2008
16
Genetics and mathematics: evidence from Prader-Willi syndrome. (17845808)
2008
17
Clinical results of cytoreduction and HIPEC in pseudomyxoma peritonei. (17633063)
2007
18
Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter. (17698848)
2007
19
Successful treatment of keratoacanthoma centrifugum marginatum with local application of imiquimod cream. (18173541)
2007
20
Doubling up on microtubule stabilizers: synergistic functions of doublecortin-like kinase and doublecortin in the developing cerebral cortex. (16387632)
2006
21
Oestrogen receptor beta and neoadjuvant therapy with tamoxifen: prediction of response and effects of treatment. (16622466)
2006
22
Intracoronary beta-irradiation prevents excessive in-stent neointimal proliferation in de novo lesions of patients with high plasma ACE levels. The BetAce randomized trial. (16263350)
2005
23
Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. (15592526)
2005
24
The low-density lipoprotein receptor-related protein associates with calnexin, calreticulin, and protein disulfide isomerase in receptor-associated-protein-deficient fibroblasts. (14980518)
2004
25
Vascular endothelial growth factor and its receptors in multiple myeloma. (14513045)
2003
26
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)- mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. (12907596)
2003
27
Ophthalmologic findings as predictors of carotid artery disease. (12476231)
2002
28
Immunotherapy of cancer using heat shock proteins. (11779704)
2002
29
Integrated nuclear fluorescence and expression of hormone-binding sites in malignant pleural effusions. (11064812)
2000
30
Intrafamilial phenotypic variation in limb-girdle muscular dystrophy type 2C with compound heterozygous mutations. (10797406)
2000
31
Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF. (11075946)
2000
32
Glycosylation of homologous immunodominant proteins of Ehrlichia chaffeensis and Ehrlichia canis. (10603362)
2000
33
Inhibition of polyamine oxidase enhances the cytotoxicity of polyamine oxidase substrates. A model study with N1-(n-octanesulfonyl)spermine and human colon cancer cells. (10856701)
2000
34
Secretory carcinoma of the canine mammary gland. (10568441)
1999
35
Compound heterozygous genotype is associated with protracted juvenile neuronal ceroid lipofuscinosis. (9450775)
1998
36
Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs. (9523114)
1998
37
Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B. (9231797)
1997
38
Serum evaluation of basic FGF in breast cancer patients. (8669845)
1995
39
Xanthogranulomatous pyelonephritis in childhood: ultrasound and CT diagnosis. (7936802)
1994
40
Actions of neurotensin: a review of the electrophysiological studies. (1463269)
1992
41
Complete sequence of the human RNA polymerase II largest subunit. (1542581)
1992
42
Social and environmental factors and dysthymic disorder in old age. (1619457)
1992
43
Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (1310894)
1992
44
Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. (2820710)
1987
45
Intestinal pseudo-obstruction as the presenting manifestation of small-cell carcinoma of the lung. A paraneoplastic neuropathy of the gastrointestinal tract. (6297344)
1983
46
Infantile hypertrophic pyloric stenosis in Greater Manchester. (6886586)
1983
47
Primary malignant lymphoma cutis. (332316)
1977
48
Paraquat poisoning treated by a replacement blood transfusion: case report. (5289746)
1971
49
Marinesco-Sjogren syndrome with myopathy. (5386591)
1969
50
EXPERIMENTAL PRODUCTION OF A SELECTIVELY HEPATIC PERIARTERITIS NODOSA. (14158903)
1964

Variations for Critical Illness Polyneuropathy

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Expression for genes affiliated with Critical Illness Polyneuropathy

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Search GEO for disease gene expression data for Critical Illness Polyneuropathy.

Pathways for genes affiliated with Critical Illness Polyneuropathy

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Pathways related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
110.0SCN4A, SCN5A
29.4CD40LG, ICAM1, SELE
39.4CD40LG, ICAM1, SELE

GO Terms for genes affiliated with Critical Illness Polyneuropathy

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Biological processes related to Critical Illness Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:00071599.9CD40LG, ICAM1
2regulation of postsynaptic membrane potentialGO:00600789.9SCN4A, SCN5A
3heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesGO:00071579.8ICAM1, SELE

Sources for Critical Illness Polyneuropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet